Packaging products

Abstract

To provide a solid preparation superior in moisture absorption preventing properties and having excellent stability without using an aluminum packing material.SOLUTION: A solid preparation contains hardened oil, the hardened oil having a melting point of 50°C or higher and being powdery having an average particle diameter of 30 μm or less. The present invention enables provision of a solid preparation superior in moisture absorption preventing properties and having excellent stability without using an aluminum packing material.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to powder and granular preparations such as tablets, powders, granules, hard capsule preparations, etc. The present invention also relates to packaged products packaged in packaging materials that have a reduced environmental impact. [Background technology]

[0002] Solid preparations such as tablets and granules are widely used in oral preparations such as Ramune candy, health foods, and medicines, as well as cleaning agents such as laundry detergents, denture cleaners, toilet cleaners, drain cleaners, and sink cleaners, and bath additives. These solid preparations have the property of absorbing moisture from the air, which can cause problems such as a decrease in the stability of the active ingredients. Therefore, formulations that prevent the hygroscopicity of solid preparations are being investigated. For example, Patent Document 1 discloses that silicon dioxide is added to a composition to prevent oxidation and moisture absorption of the Salacia plant extract and to enhance the storage stability of the composition. Furthermore, Patent Document 2 discloses that the addition of indigestible dextrin to tablets containing processed kudzu flowers improves their stability against humidity. Patent Document 3 discloses that the moisture absorption of oligosaccharides can be suppressed by coating the surface of the oligosaccharides with an oily component having a melting point of 40° C. or higher. [Prior art documents] [Patent documents]

[0003] [Patent Document 1] Japanese Patent Application Laid-Open No. 2011-178690 [Patent Document 2] Japanese Patent Application Laid-Open No. 2006-262888 [Patent Document 3] Japanese Patent Application Laid-Open No. 2004-175713 Summary of the Invention [Problem to be solved by the invention]

[0004] Aluminum packaging is used to prevent solid dosage forms from absorbing moisture. However, aluminum packaging requires a large amount of energy to produce and has the problem of emitting a large amount of carbon dioxide. In recent years, producers of solid dosage forms have been required to reduce carbon dioxide emissions as a measure against global warming.

[0005] An object of the present invention is to provide a solid preparation which has excellent moisture absorption prevention properties and excellent stability even without using an aluminum packaging material. [Means for solving the problem]

[0006] As a result of intensive research to solve the above problems, the present inventors have found that the hygroscopicity of a solid preparation can be suppressed by mixing a hydrogenated oil or fat having a specific melting point in the form of a powder having a specific average particle size with the solid preparation, and have completed the present invention. That is, the present invention relates to the following packaged product.

[0007] [1] A packaging product comprising a tablet and a packaging material for packaging the tablet, The tablet contains powdered hardened oils and fats having a melting point of 50°C or higher and an average particle size of 30 μm or less, A packaged product, wherein the packaging material does not contain an aluminum layer. [2] A packaged product comprising a powdered or granular formulation and a packaging material for packaging the powdered or granular formulation, The powder / granular preparation contains a powdered hardened oil or fat having a melting point of 50°C or higher and an average particle size of 30 μm or less, A packaged product, wherein the packaging material does not contain an aluminum layer. [3] A packaged product comprising a hygroscopic substance or a discoloration inducer and a packaging material for packaging the hygroscopic substance or the discoloration inducer, The hygroscopic substance or the discoloration inducer is coated with a powdery hardened oil or fat having a melting point of 50°C or higher and an average particle size of 30 μm or less, A packaged product, wherein the packaging material does not contain an aluminum layer. [4] The packaging material has a water vapor permeability of 0.01 g / m 2 ·day or more, 4.0g / m 2 The packaged product according to any one of [1] to [3], characterized in that it has a shelf life of 10 days or less. [Effects of the Invention]

[0008] According to the present invention, a solid preparation having excellent moisture absorption prevention properties and excellent stability without using an aluminum packaging material can be provided. DETAILED DESCRIPTION OF THE INVENTION

[0009] The present invention relates to a solid preparation containing hydrogenated fats and oils, characterized in that the hydrogenated fats and oils are in a powder form having a melting point of 50°C or higher and an average particle size of 30 μm or less. The solid preparation may be a powder formulation such as a powder, granule, or hard capsule formulation, or a tablet. The solid preparation of the present invention may also be an oil-coated preparation in which the surface of a hygroscopic substance or a discoloration inducer is coated with hydrogenated fats and oils. The solid preparation of the present invention has excellent moisture absorption prevention properties due to the inclusion of hydrogenated fats and oils, and therefore exhibits excellent stability even without the use of aluminum packaging.

[0010] (hardened oil) The hardened fats and oils used in the present invention are hardened products obtained by hydrogenating fats and oils derived from plants or animals, and have a melting point of 50°C or higher. Examples of hardened fats and oils include vegetable oils such as soybean oil, cottonseed oil, safflower oil, rice oil, corn oil, rapeseed oil, palm oil, perilla oil, perilla oil, cocoa butter, peanut oil, coconut oil, evening primrose oil, and borage oil; animal oils such as lard, beef tallow, milk fat, chicken oil, and whale oil; and fish oils such as tuna oil, sardine oil, mackerel oil, saury oil, bonito oil, herring oil, and cod liver oil. These fats and oils can be used alone or in combination. The hardened fats and oils include partially hydrogenated fats in which the unsaturated fatty acids of the fats and oils have been partially hydrogenated, and fully hydrogenated fats in which the unsaturated fatty acids have been completely hydrogenated (hereinafter referred to as "extremely hardened fats and oils").

[0011] The hardened oils and fats used in the present invention are preferably extremely hardened oils and fats. Here, extremely hardened oils and fats are oils and fats in a state where unsaturated fatty acids are almost absent, for example, oils and fats with an iodine value of 3 or less. The iodine value can be measured by "2.4.5.3-92 Iodine value (Wiess-cyclohexane method)" in the Standard Methods for Analysis of Fats, Oils, and Related Materials. In the present invention, the use of extremely hydrogenated oils and fats has the effect of providing particularly excellent moisture absorption prevention performance. Furthermore, extremely hydrogenated oils and fats have low agglomeration tendency as fine powders with an average particle size of 30 μm or less compared to other high-melting-point lipids such as waxes, and can be sufficiently mixed into solid preparations even with a mixer with weak stirring power.

[0012] The melting point of the hydrogenated fat used in the present invention is 50°C or higher, preferably 55°C or higher, and more preferably 60°C or higher. The upper limit is not particularly limited, but is preferably 80°C or lower, more preferably 75°C or lower, and even more preferably 70°C or lower. The melting point of the hydrogenated fat can be measured in accordance with "2.2.4.2 Melting Point (Slip Melting Point)" of the Standard Fats and Oils Analysis Test Method. If the melting point of the hydrogenated fat is lower than 50°C, it is difficult to obtain a fine powder with an average particle size of 30 μm or less, and sufficient moisture absorption prevention effect cannot be obtained even when added to a solid formulation. Furthermore, a higher melting point not only improves the moisture absorption prevention performance of the solid formulation, but also reduces the coagulation tendency of the fine powder with an average particle size of 30 μm or less, allowing it to be sufficiently mixed into a solid formulation even with a mixer with weak stirring power.

[0013] The hardened oil used in the present invention is particularly preferably extremely hardened rapeseed oil, which has the effects of being particularly excellent in moisture absorption prevention performance, low coagulation tendency of fine powder, and excellent mixability with solid preparations.

[0014] The hydrogenated fats used in the present invention are in powder form with an average particle size of 30 μm or less. The average particle size of the powdered hydrogenated fats can be measured using a laser diffraction particle size distribution analyzer "SALD-2100" (manufactured by Shimadzu Corporation). By mixing a fine powder of hydrogenated fats with an average particle size of 30 μm or less into the solid formulation of the present invention, the fine powder of hydrogenated fats is disposed in the gaps between particles of powders, granules, powders for tableting, etc., making the entire solid formulation hydrophobic and preventing moisture penetration into the solid formulation. If the average particle size of the hydrogenated fat powder exceeds 30 μm, the hydrogenated fats disposed in the gaps between particles of powders, granules, powders for tableting, etc. become sparse, and sufficient moisture absorption prevention effect cannot be achieved.

[0015] The method for producing powdered hardened oils and fats having an average particle size of 30 μm or less is not particularly limited, and examples thereof include a method in which heated and melted hardened oils and fats are cooled into plate or flake shapes and then crushed in a crusher, a method in which heated and melted hardened oils and fats are powdered by spray cooling, etc. Furthermore, powdered hardened oils and fats having an average particle size of 30 μm or less can be obtained by classifying the hardened oils and fats powdered by a crusher or spray cooling with a sieve having an opening of 50 μm or less, preferably 30 μm or less.

[0016] The content of hydrogenated oils and fats in a solid preparation is not particularly limited, but is, for example, 1% by mass to 30% by mass. The lower limit is preferably 3% by mass or more, more preferably 5% by mass or more. The upper limit is preferably 20% by mass or less, more preferably 10% by mass or less. A higher content of hydrogenated oils and fats provides an excellent moisture absorption prevention effect. On the other hand, a lower content of hydrogenated oils and fats provides an effect of allowing an increase in the content of the active ingredient.

[0017] [First embodiment (tablet)] Tablets, which are an embodiment of the solid preparation of the present invention, can be obtained by molding a powder for tableting containing an active ingredient, excipients, lubricants, glidants, etc. The powder for tableting may be granulated using a fluidized bed granulator, a high-speed stirring granulator, or the like before molding.

[0018] The active ingredient is not particularly limited, but examples thereof include carnitine, vitamin C, ferric pyrophosphate, calcium pantothenate, and α-GPC.

[0019] Examples of excipients include reducing sugars such as lactose, dextrin, crystalline cellulose, starch, corn starch, maltitol, lactitol, xylitol, and erythritol; sugars such as fructose, sucrose, and glucose; gums such as gum arabic, xanthan gum, tragacanth gum, guar gum, gellan gum, and locust bean gum; and proteins such as sodium caseinate, skim milk powder, milk protein, and whey protein. Among these, lactose, dextrin, crystalline cellulose, and maltitol are preferred.

[0020] Examples of lubricants include calcium stearate, sucrose fatty acid esters, etc. Examples of flow agents include fine silicon dioxide, etc.

[0021] The powder for tableting and tablets of the present invention contain powdered hydrogenated oils and fats having a melting point of 50° C. or higher and an average particle size of 30 μm or less. The means for mixing the powder for tableting and powdered hydrogenated oils and fats is not particularly limited, and examples include mixing using a simple mixer such as a drum mixer or a V-shaped mixer, or mixing using a high-speed stirring granulator equipped with a stirring blade or a crushing blade inside the vessel.

[0022] In the tableting powder and tablets, the content of powdered hydrogenated oils and fats having a melting point of 50°C or higher and an average particle size of 30 μm or less is not particularly limited, but is, for example, 1% to 30% by mass. The lower limit is preferably 3% by mass or higher, more preferably 5% by mass or higher. The upper limit is preferably 20% by mass or lower, more preferably 10% by mass or lower. A higher hydrogenated oil and fat content provides an excellent moisture absorption prevention effect. On the other hand, a lower hydrogenated oil and fat content provides an increased content of the active ingredient. In addition, in the case of tablets, a lower hydrogenated oil and fat content provides the effects of suppressing the occurrence of tableting problems such as sticking and of providing excellent tablet disintegration properties.

[0023] [Second embodiment (powder formulation)] The powdered or granular preparation, which is an embodiment of the solid preparation of the present invention, is a powder containing an active ingredient, an excipient, a fluidizing agent, a binder, etc., or a granule consisting of granules. The method for producing the granules may be either wet granulation or dry granulation, and examples thereof include fluidized bed granulation, agitation granulation, extrusion granulation, and compression granulation.

[0024] The active ingredient, excipient, and fluidizing agent can be the same as those used in tablets. Examples of binders include hydroxypropyl cellulose, pullulan, starch, and dextrin.

[0025] The powdered granular formulation of the present invention contains powdered hydrogenated oils and fats having a melting point of 50°C or higher and an average particle size of 30 μm or less. The means for mixing the powdered granular formulation with the powdered hydrogenated oils and fats is not particularly limited, and examples include mixing using a simple mixer such as a drum mixer or a V-shaped mixer, or mixing using a high-speed stirring granulator equipped with a stirring blade or a crushing blade inside the vessel. When mixing the hydrogenated oils and fats with the granules, the hydrogenated oils and fats may be mixed before, during, or after granulation.

[0026] The form of the powder / granular preparation of the present invention is not particularly limited, and examples thereof include a pouch with a zipper, a three-side sealed package, a four-side sealed package, a stick package, etc. The powder / granular preparation may also be filled into a hard capsule to form a hard capsule preparation.

[0027] In a powdered or granular formulation, the content of powdered hydrogenated oils and fats having a melting point of 50°C or higher and an average particle size of 30 μm or less is not particularly limited, but is, for example, 1% to 30% by mass. The lower limit is preferably 3% by mass or higher, more preferably 5% by mass or higher. The upper limit is preferably 20% by mass or lower, more preferably 10% by mass or lower. A higher content of hydrogenated oils and fats provides an excellent moisture absorption prevention effect. On the other hand, a lower content of hydrogenated oils and fats provides an effect of allowing the content of active ingredients to be increased. Furthermore, in the case of a powdered or granular formulation, a lower content of hydrogenated oils and fats provides an effect of excellent melt-in-the-mouth feel.

[0028] [Third embodiment (oil-coated formulation)] The oil-coated preparation, which is an embodiment of the solid preparation of the present invention, is an oil-coated granular product in which the surface of a hygroscopic substance or a discoloration inducer is coated with powdery hardened oil having a melting point of 50°C or higher and an average particle size of 30 μm or less.

[0029] A hygroscopic substance is a powdery substance that solidifies or liquefies when placed in a petri dish (approximately 5 g) and stored at 40°C and 75% humidity for three days. Discoloration inducers are substances that induce discoloration when present together in a solid formulation, such as vitamin C and iron ions, vitamin C and calcium ions, or sugars and amino acids. These substances are thought to accelerate discoloration due to the influence of moisture. Discoloration inducers can be identified as those that cause discoloration in a test in which approximately 5 g is placed in a petri dish and stored at 40°C and 75% humidity for 3 days.

[0030] In the oil-and-fat coating preparation, the content of powdery hydrogenated oils and fats having a melting point of 50°C or higher and an average particle size of 30 μm or less is not particularly limited, but is, for example, 1% by mass to 30% by mass. The lower limit is preferably 3% by mass or higher, more preferably 5% by mass or higher. The upper limit is preferably 20% by mass or lower, more preferably 10% by mass or lower. A higher content of hydrogenated oils and fats provides an excellent moisture absorption prevention effect. On the other hand, a lower content of hydrogenated oils and fats provides an effect of allowing the content of active ingredients to be increased.

[0031] The oil-coated granules can be produced by mixing a hygroscopic substance or discoloration inducer with a powdered hardened oil or fat having a melting point of 50°C or higher and an average particle size of 30 μm or less in a high-speed agitating granulator equipped with a stirring blade or a crushing blade in a vessel. Examples of high-speed agitating granulators include a high-speed mixer (Shinku Powtec Co., Ltd.) and a vertical granulator (Powrex Corporation). The rotation speed of the stirring blade or the crushing blade and the mixing time can be appropriately set depending on the type of hygroscopic substance or discoloration inducer.

[0032] The average particle size of the hygroscopic substance or discoloration inducer is 50 μm or more, preferably 80 μm or more, and more preferably 100 μm or more. The average particle size of the hygroscopic substance or discoloration inducer can be measured using a laser diffraction particle size distribution analyzer "SALD-2100" (manufactured by Shimadzu Corporation). If the average particle size of the hygroscopic substance or discoloration inducer is less than 50 μm, the powdery hydrogenated oil and fat with an average particle size of 30 μm or less will not adhere to the surface, and the surface cannot be covered with the hydrogenated oil and fat.

[0033] The average particle size of the hygroscopic substance or discoloration inducer may be adjusted by granulation before coating the surface with powdered hydrogenated oil or fat having an average particle size of 30 μm or less. The granulation method may be either wet granulation or dry granulation, for example, fluidized bed granulation, agitation granulation, extrusion granulation, compression granulation, etc.

[0034] The binder is not particularly limited, but examples thereof include hydroxypropyl cellulose, hydroxypropylmethyl cellulose, pullulan, corn protein (zein), shellac, starch, etc. From the viewpoint of further enhancing moisture absorption prevention performance, water-insoluble binders such as corn protein and shellac can be suitably used.

[0035] [Fourth embodiment (packaged product)] The packaged product of the present invention is characterized by combining the solid formulation of the present invention (tablet, powder formulation, oil-coated formulation) with a packaging material that does not contain an aluminum layer. This makes it possible to provide a packaged product that does not contain an aluminum layer, thereby reducing carbon dioxide emissions. The aluminum layer is a layer of aluminum foil, and a packaged product that includes an aluminum layer is a packaged product that uses a so-called aluminum laminate.

[0036] The water vapor permeability of the packaging material is not particularly limited, but is, for example, 5.0 g / m 2 ·day or less, preferably 4.0 g / m 2 ·day or less, and more preferably 3.0 g / m 2 ·day or less, and more preferably 2.0 g / m 2 1.0 g / m or less, and particularly preferably 1.0 g / m 2 This makes it possible to provide packaging products with particularly excellent moisture absorption prevention performance. The upper limit of the water vapor permeability of the packaging material is preferably 0.01 g / m 2 ·day or more.

[0037] The packaging material is not particularly limited, but examples include polyethylene terephthalate (PET), polyethylene (PE), unstretched polypropylene (CPP), oriented nylon (ONY), and polyvinyl chloride. Films with improved barrier properties, such as silica vapor deposition films and alumina vapor deposition films, may also be used. Single-layer films or laminates made of these materials can be used. PP bottles and cartons are also suitable.

[0038] The form of the packaging material is not particularly limited, but examples thereof include pouch packaging, PTP (press through pack) packaging, etc. Examples of pouch packaging include pouches with zippers, three-sided sealed packaging, four-sided sealed packaging, stick packaging, etc. Alternatively, the product may be filled into a resin bottle, carton container, etc. [Example]

[0039] [Effect of packaging materials on oil-coated preparations] The present invention will be described in more detail below with reference to examples. The blending amounts in the examples are based on mass.

[0040] (Manufacturing method of vitamin C coated products) 600g of vitamin C and 150g of extremely hardened rapeseed oil (melting point 68°C, average particle size 20μm) were mixed in a high-speed agitating granulator to coat the surface of the vitamin C with the extremely hardened rapeseed oil.The mixture was then sieved through a 20 mesh screen to obtain a vitamin C-coated product.

[0041] (Method of manufacturing ferric pyrophosphate coated products) 600 g of ferric pyrophosphate and 150 g of extremely hardened rapeseed oil (melting point 68°C, average particle size 20 μm) were mixed in a high-speed agitating granulator to coat the surface of the ferric pyrophosphate with the extremely hardened rapeseed oil.The mixture was then sieved through a 20-mesh sieve to obtain an ferric pyrophosphate-coated product.

[0042] (Manufacturing method of calcium pantothenate coated product) A spray solution was prepared by dissolving 80 g of corn protein in aqueous ethanol (70% ethanol by volume). Using a fluidized bed granulator, the spray solution was sprayed onto 720 g of calcium pantothenate and dried to obtain a primary granulated coating. 666.8 g of the resulting primary granulated coating was mixed with 83.3 g of extremely hardened rapeseed oil (melting point 68°C, average particle size 20 μm) in a high-speed agitating granulator to coat the surface of the primary granulated coating with the extremely hardened rapeseed oil. The mixture was then sieved through a 20-mesh screen to obtain a calcium pantothenate-coated product.

[0043] (Production method of α-GPC coated products) A mixed powder containing 225 g of α-GPC, 367.5 g of crystalline cellulose A, and 7.5 g of silicon dioxide was mixed with 150 g of extremely hardened rapeseed oil (melting point 68°C, average particle size 20 μm) using a high-speed agitator granulator, and the surface of the mixed powder was coated with the extremely hardened rapeseed oil.The mixture was then sieved through a 20-mesh sieve to obtain an α-GPC-coated product.

[0044] (Method of manufacturing arginine-coated products) A mixed powder containing 225 g of arginine, 367.5 g of crystalline cellulose A, and 7.5 g of silicon dioxide was mixed with 150 g of extremely hardened rapeseed oil (melting point 68°C, average particle size 20 μm) using a high-speed agitator granulator, and the surface of the mixed powder was coated with the extremely hardened rapeseed oil.The mixture was then sieved through a 20-mesh sieve to obtain an arginine-coated product.

[0045] (Manufacturing method of carnitine tartrate coated product) 600 g of carnitine tartrate and 150 g of extremely hardened rapeseed oil (melting point 68°C, average particle size 20 μm) were mixed in a high-speed agitating granulator to coat the surface of the carnitine tartrate with the extremely hardened rapeseed oil.Then, the mixture was sieved through a 20-mesh sieve to obtain a carnitine tartrate-coated product.

[0046] <Storage test for powders and tablets> The raw materials shown in Tables 1-1, 1-2, 2-1, and 2-2 were weighed out to a total weight of 50 g and then uniformly mixed to produce a powder formulation containing an oil-coated formulation. A drum mixer was used to mix the powder formulation. Furthermore, the raw materials shown in Tables 3-1, 3-2, 4-1, and 4-2 were weighed out to a total weight of 3 kg, and tablets were produced by the method described below. (Tablet manufacturing) The raw materials were mixed using a drum mixer and then sieved through a 30 mesh screen to obtain powder for tableting. Approximately 1,000 tablets were produced using this powder for tableting, with a particle weight of 300 mg per tablet, a diameter of 9 mm, a radius of 12 mm, and a tablet hardness of 10 to 12 kgf.

[0047] The powder formulation and tablets were filled into packaging materials 1 to 4 shown in the table, and the test was carried out under the following storage conditions. (Storage conditions) The samples for storage test (powder: 5 g, tablets: 10 tablets) were placed in packaging materials 1 to 4, heat-sealed, and stored at 40°C and 75% humidity for one month.

[0048] (Test 1) Evaluation of discoloration of powders and tablets The powders and tablets after the storage test were compared with those immediately after production, and the degree of discoloration was visually confirmed. The evaluation criteria for discoloration are as follows: <Evaluation criteria for discoloration> -: No discoloration +: Partial discoloration ++: Overall discoloration +++: Strong overall discoloration

[0049] (Test 2) Evaluation of powder moisture absorption The powder after the storage test was compared with that immediately after production, and the degree of moisture absorption was visually confirmed. The evaluation criteria for moisture absorption were as follows: <Evaluation criteria for powder moisture absorption> -:no change +: There are lumps ++: Consolidation +++: Liquefaction

[0050] (Test 3) Evaluation of tablet moisture absorption After the storage test, the tablet surfaces were visually inspected. The evaluation criteria for moisture absorption were as follows: <Evaluation criteria for tablet moisture absorption> -: No abnormalities +: Uneven surface ++: Cracks and chips +++: The entire tablet is sticky

[0051] [Table 1]

[0052] Comparing Example 1-(4) with Comparative Example 1-(4), it was found that mixing an oil-coated preparation in which the active ingredient is coated with hardened oil in powder form with a melting point of 50°C or higher and an average particle size of 30 μm or less with a powdered granular preparation improves the moisture absorption inhibitory performance of the powdered granular preparation. Furthermore, comparing Example 1-(4) with Comparative Example 1-(4) and Example 1-(6) to Example 1-(8) with Comparative Examples 1-(6) to 1-(8), discoloration of the powder was suppressed. This discoloration of the powder is thought to be due to the promotion of reactions between vitamin C and iron, and between vitamin C and calcium, caused by the transfer of moisture to the powder formulation. The reason why no differences were observed in the hygroscopicity test when comparing Example 1-(6) to Example 1-(8) with Comparative Examples 1-(6) to 1-(8) is thought to be that although moisture was absorbed, the effect was not so great as to change the state of the powder.

[0053] Furthermore, in the examples, when comparing packaging materials 1 to 4, the water vapor permeability of the packaging material is 4.0 g / m 2 On the other hand, in the comparative example, the water vapor permeability of the packaging material was 4.0 g / m 2 Even when the treatment time was less than 1 day, sufficient discoloration suppression effect could not be obtained. That is, the oil-coating formulation technology and the water vapor permeability of 4.0 g / m 2 It was found that by combining the following packaging materials, sufficient moisture absorption prevention performance can be achieved without using aluminum packaging.

[0054] [Table 2]

[0055] Looking at Tables 2-1 and 2-2, the same trends as those in Tables 1-1 and 1-2 were observed. Therefore, it was found that the effects of the present invention can be exhibited regardless of the type of core material of the oil-coated preparation.

[0056] [Table 3]

[0057] [Table 4]

[0058] Looking at Tables 3-1, 3-2, 4-1, and 4-2, the same trends as those in Tables 1-1, 1-2, 2-1, and 2-2 were observed. Therefore, it was found that the effects of the present invention are also exhibited in tablets containing an oil-coated formulation.

[0059] The packaging materials used in this example are as follows: (Packaging material used) Packaging material 1: Seisan Nipponsha "Lamizip Aluminum Bag AL-12" (120mm x 180mm, PET / AL / PE) Packaging material 2: Packaging material using Toppan Printing Co., Ltd.'s "GX-PF" (130mm x 180mm, GX-PF / CPP50) Packaging material 3: Packaging material using Toppan Printing Co., Ltd.'s "GL Film" (130mm x 180mm, MR-PET・GL12 / ONY15 / CPP70) Packaging material 4: Meiwa Pax Co., Ltd. "OX-1318H" (130mm x 180mm) Water vapor permeability of packaging material (unit: g / m 2 ·day) was measured under conditions of 40°C and 90% RH according to JIS "K7129B" method. Note that "PET" is an abbreviation for polyethylene terephthalate, "AL" is an abbreviation for aluminum foil, "PE" is an abbreviation for polyethylene, "CPP" is an abbreviation for unstretched polypropylene, and "ONY" is an abbreviation for oriented nylon.

[0060] The raw materials used in this example are as follows: (Raw materials used) *Extremely hardened rapeseed oil (melting point 68°C, average particle size 20μm): Flake-shaped extremely hardened rapeseed oil is crushed in a mill and the crushed material is sieved through a 300 mesh (openings 50μm). *Vitamin C: Fuso Chemical Co., Ltd. "Vitamin C Type S" *Ferric pyrophosphate: Taihei Chemical Industry Co., Ltd. "Ferric pyrophosphate" *Calcium pantothenate: BASF Japan Ltd. "Calcium pantothenate" *Carnitine tartrate: Lonza Co., Ltd. "Carnipure Tartrate CN" *Arginine: Kyowa Hakko Bio Co., Ltd. "L-Arginine Kyowa" *α-GPC:Lipoid GmbH “LIPOID GPC” *Corn protein: Kobayashi Zein DP-N, Kobayashi Fragrance Co., Ltd. *Hydrated ethanol: Amakasu Chemical Industry Co., Ltd. "Amanol JP" *Maltodextrin: Matsutani Chemical Industry Co., Ltd. "Pinex #2" *Maltitol: Mitsubishi Corporation Foodtech Co., Ltd. "Amalty MR-50" *Crystalline cellulose A: Asahi Kasei Corporation "Ceolas UF-F711" *Crystalline cellulose B: Asahi Kasei Corporation "Ceolas UF-F701" *Crystalline cellulose C: Asahi Kasei Corporation "CEOLUS ST-100" *Starch 1: Matsutani Chemical Industry Co., Ltd. "Potato Starch ER" *Starch 2: "ST Starch P" by Nippon Starch Chemical Co., Ltd. *Hydroxypropyl cellulose: "Cellny SSL" by Nippon Soda Co., Ltd. *Silicon dioxide: Fuji Silysia Chemical Ltd. "Silopeg 720" *Calcium stearate: Taihei Chemical Industry Co., Ltd. "Calcium stearate (vegetable)" [Industrial Applicability]

[0061] The present invention can be suitably used to prevent moisture absorption in foods such as Ramune candy, health foods such as supplements, and oral preparations such as medicines.The present invention can also be used in cleaning agents such as laundry detergents, denture cleaners, toilet cleaners, drain cleaners, and washbasin cleaners, as well as bath additives.

Claims

[Claim 1] A packaged product comprising a solid preparation containing a hygroscopic substance or a discoloration inducer and a hardened oil and fat, and a packaging material for packaging the hygroscopic substance or the discoloration inducer, The hygroscopic substance or the discoloration inducer is coated with the hardened oil or fat in a powder form having a melting point of 50°C or higher and an average particle size of 30 μm or less, the hygroscopic substance or the discoloration inducer has an average particle size of 50 μm or more and is one or more selected from the group consisting of vitamin C, ferric pyrophosphate, calcium pantothenate, arginine, and α-GPC; In the solid preparation, the content of the hydrogenated oil or fat is 1% by mass or more and 30% by mass or less, The packaging material has a water vapor permeability of 0.01 g / m 2 ·day or more and 1.0 g / m 2 ·day or less, and does not contain an aluminum layer.

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