Bottled liquid composition

Abstract

To provide a packed liquid composition which is, when applied particularly to a skin surface, excellent in disinfection and or virus destroying activity and a prolonged effect of the same.SOLUTION: A packed liquid composition is provided which is obtained by housing a liquid composition in a container, wherein the liquid composition contains a component (A): one or more polyols satisfying logPow value≥-0.3; and a component (B): a disinfectant other than alcohol-based ones, and wherein a content of the component (A) is 0.05 mass% to 30 mass% and a content of the (B) component is 0.01 mass% to 10 mass%, a content of glyceryl trioctanoate is less than 2 mass%, and the pH of the liquid composition at 25°C is 3.5 to 7.0.SELECTED DRAWING: None

Description

[Technical Field]

[0001] The present invention relates to a containerized liquid composition. More specifically, to a containerized liquid composition suitable for topical skin preparations for bactericidal and / or antiviral purposes. [Background technology]

[0002] Recent studies have shown that contact transmission is a common route of bacterial or viral infection in daily life. Contact transmission primarily occurs when hands come into contact with infected individuals, doorknobs, handles, dishes, toys, other everyday items, interior furnishings, and other objects.

[0003] There is a need for methods to prevent contact transmission of bacteria or viruses through such everyday contact activities. One known method for preventing contact transmission of bacteria or viruses through the hands is to apply alcohol-based disinfectants to the hands to kill and disinfect them. However, alcohols such as ethanol used as disinfectants are highly volatile, and their effectiveness in providing bactericidal and antiviral effects to the hands is not sufficiently sustained.

[0004] Therefore, methods are being considered to pre-apply protective functions against bacteria or viruses to the hands. According to these methods, a continuous effect of preventing infection by bacteria or viruses can be obtained, making it possible to prevent contact infection even in environments where there are no handwashing facilities, such as when going out. This is particularly preferable because it can prevent infection even when repeatedly coming into contact with objects to which bacteria or viruses have adhered.

[0005] For example, Patent Document 1 discloses a method for suppressing bacteria and viruses present on the surface of mammalian skin, which involves contacting the skin with a compound or composition capable of reducing the skin pH to less than about 4 for at least about 0.5 hours. It is also stated that the compound or composition capable of reducing the skin pH further comprises an antimicrobial agent selected from the group consisting of phenolic antimicrobial agents, quaternary ammonium antimicrobial agents, anilides, bisguanidines, and mixtures thereof.

[0006] Other known skin disinfection compositions containing bactericidal or antibacterial agents are available (for example, Patent Document 2). Patent Document 2 discloses a long-lasting antibacterial cream comprising a cationic disinfectant, a lower alcohol, an oily base, a higher aliphatic alcohol, a lipophilic and hydrophilic nonionic surfactant, a water-soluble polyhydric alcohol, and purified water, which possesses both a sustained disinfecting effect on the skin, hands, and wounds, as well as an effect of preventing skin irritation. [Prior art documents] [Patent Documents]

[0007] [Patent Document 1] Special Publication No. 2008-523064 [Patent Document 2] Japanese Patent Publication No. 2007-284412 [Overview of the project] [Problems that the invention aims to solve]

[0008] In disinfectants for the skin of fingers and the like, cationic germicides such as benzalkonium chloride are generally used. However, according to the study by the inventors, it has been found that the skin surface of humans is less likely to obtain a bactericidal effect by bactericides other than alcohol-based ones, such as cationic germicides, compared with inorganic substances such as stainless steel and glass. In addition, the blending amount of germicides and antibacterial agents in skin compositions may be substantially limited from the viewpoint of safety to the human body and the like. Therefore, the bactericidal and antiviral activities of the skin by germicides or antibacterial agents and their sustained effects are not sufficient, and further improvement has been desired. Also, in Patent Document 2, after hand washing, a bactericidal disinfectant is applied to unsterilized fingers, and the reduction rate of the number of bacteria after disinfection with respect to the number of bacteria before disinfection is evaluated. However, whether the bactericidal and antiviral effects can be continuously exhibited when the fingers are previously imparted with a defensive function against bacteria or viruses and then bacteria or viruses adhere has not been examined, and there is room for improvement in this regard.

[0009] The present invention relates to a container-filled liquid composition that is excellent in bactericidal and / or antiviral activities and their sustained effects, particularly when applied to the skin surface.

Means for Solving the Problems

[0010] The inventors have found that a container-filled liquid composition obtained by containing a polyol and a germicide that satisfy predetermined requirements in predetermined amounts, and having a content of a specific oily component of not more than a predetermined amount and a pH within a predetermined range, is excellent in bactericidal and / or antiviral activities and their sustained effects.

[0011] That is, the present invention relates to the following. [1] Component (A): logP ,

[0011] ,

[0010] , , <#0000089#>, <#0000001#>, <#0000087#>, <#0000098#>, <#0000088#>, <##0000099#>, <##0000096#>, <#0000086#>, <#0000097#>, <#0000094#>, <#0000095#> One or more polyols satisfying a value ≧ -0.3, and, Component (B): A germicide other than an alcohol-based one, containing, the content of the component (A) is 0.05% by mass or more and 30% by mass or less, The content of component (B) is 0.01% by mass or more and 10% by mass or less. A containerized liquid composition comprising a liquid composition containing less than 2% by mass of glycerin trioctanoate and having a pH of 3.5 or higher and 7.0 or lower at 25°C, contained in a container. [2] A method for protecting skin from bacteria or viruses, comprising the step of applying the liquid composition contained in a container to the skin, using the liquid composition described in [1] above. [3] Use of a polyol (A) satisfying a logPow value ≥ -0.3 to enhance or prolong the bactericidal effect of a non-alcohol-based disinfectant (B) on the skin. [Effects of the Invention]

[0012] According to the present invention, it is possible to provide a bottled liquid composition that exhibits excellent bactericidal and / or virucidal activity and sustained effects, particularly when applied to the skin surface. This bottled liquid composition is useful as a bottled liquid topical skin preparation composition for bactericidal and / or virucidal purposes. [Modes for carrying out the invention]

[0013] [Containerized liquid composition] The liquid composition in a container of the present invention, Component (A):logP ow One or more polyols satisfying a value ≥ -0.3, and Ingredients (B): Disinfectants other than alcohol-based disinfectants, The present invention comprises a liquid composition containing the following, wherein the content of component (A) is 0.05% by mass or more and 30% by mass or less, the content of component (B) is 0.01% by mass or more and 10% by mass or less, the content of glycerin trioctanoate is less than 2% by mass, and the pH at 25°C is 3.5 or more and 7.0 or less, which is contained in a container. Hereinafter, the containerized liquid composition of the present invention will also be referred to as "the liquid composition of the present invention," and the liquid composition that is the contents of the container will also be referred to as "the liquid composition used in the present invention." The containerized liquid composition of the present invention, having the above-described structure, exhibits excellent bactericidal and / or antiviral activity and sustained effects, particularly when the liquid composition contained in the container is applied to the skin surface. In this invention, the alcohol-based disinfectant refers to monoalcohols with four or fewer carbon atoms, such as ethanol and isopropanol. The containerized liquid composition of the present invention, since the liquid composition is contained in a container, can suppress the volatilization of component (A) during storage. Examples of such containers include spray type, pump type, and squeeze type press-type containers.

[0014] The reason why the containerized liquid composition of the present invention exhibits bactericidal and / or antiviral activity and its sustained effect is not entirely clear, but it is thought to be as follows. As described above, our studies have revealed that the surface of human skin is difficult to disinfect with non-alcohol-based disinfectants. This is presumed to be due to the interaction between the disinfectant and the skin. Examples of disinfectants other than alcohol-based disinfectants include one or more selected from the group consisting of cationic disinfectants, iodine-based disinfectants, phenol-based disinfectants, biguanide-based disinfectants, terpenoid-based disinfectants, chlorine-based disinfectants, and amphoteric surfactant-based disinfectants. Of these, it is thought that when cationic disinfectants such as benzalkonium chloride or amphoteric surfactant-based disinfectants are applied, the positive charge of the disinfectant is captured by the negative charge of the skin, causing it to adsorb to the skin and reducing its bactericidal and / or antiviral activity. In the case of iodine-based and chlorine-based disinfectants, they are inactivated in the presence of organic matter, so it is thought that their bactericidal and / or antiviral activity on the skin surface is reduced. In addition, it is thought that phenol-based and terpenoid-based disinfectants adsorb to the skin through hydrophobic interactions, thus reducing their bactericidal and / or antiviral activity.

[0015] Therefore, the inventors focused on polyols as components that can effectively exhibit bactericidal and / or antiviral activity even on the skin surface. The polyol, which is component (A), has an octanol / water partition coefficient of logP owThis is a polyol that satisfies the value ≥ -0.3. Component (A) has a hydrophilic hydroxyl group and a hydrophobic part containing a carbon atom. The hydrophilic part has a high affinity for water molecules and forms interactions with them. On the other hand, the hydrophobic part distorts or disrupts the three-dimensional hydrogen bond network of water. This is the same effect as ethanol, etc. This distortion or disruption of the three-dimensional hydrogen bond network of water changes the water environment around bacteria and viruses. This change is thought to have the effect of denaturing, for example, hydrophilic membrane proteins. Here, logP ow The higher the value, the higher the hydrophobicity. Component (A) has a hydrophobicity above a certain level, and is thought to be likely to have the effect of distorting or breaking the three-dimensional hydrogen bond network of water. Furthermore, component (A) has lower volatility than the aforementioned alcohol-based disinfectant, and even after applying a liquid composition containing component (A) to the skin, it can remain near the skin surface at a high concentration for a long time. Therefore, it is considered to have excellent sustained bactericidal and / or antiviral activity. Moreover, component (A) also acts as a solvent for component (B) on the skin surface, suppressing the adsorption of component (B) to the skin surface, and thus is thought to have the effect of suppressing the decrease in the bactericidal and / or antiviral activity of component (B). Based on the above mechanism of action, it is believed that by using the liquid composition in a container of the present invention, component (A) itself exhibits bactericidal and / or antiviral activity, while suppressing the decrease in the bactericidal and / or antiviral activity of component (B), and that a synergistic effect of bactericidal and / or antiviral activity can be obtained by using component (A) and component (B) together.

[0016] Furthermore, it is believed that the pH of the liquid composition used in this invention is between 3.5 and 7.0 at 25°C, which improves the bactericidal and / or antiviral activity and its sustained effect while suppressing skin irritation. Furthermore, the liquid composition used in the present invention contains less than 2% by mass of glycerin trioctanoate. When glycerin trioctanoate is included at 2% by mass or more, it inhibits contact between components (A) and (B) and bacteria and / or viruses, reducing the bactericidal effect. This is thought to be because an oil film is formed on the skin by glycerin trioctanoate, and components (A) and (B) are coated by this oil film, making it difficult for them to act on bacteria. On the other hand, by limiting the content of glycerin trioctanoate in the liquid composition used in the present invention to less than 2% by mass, bactericidal and / or antiviral activity, as well as its sustained effect, can be obtained. Furthermore, from the viewpoint of obtaining bactericidal and / or antiviral activity and its sustained effect, the content of glycerin trioctanoate is preferably 1.9% by mass or less, more preferably 1.8% by mass or less, even more preferably 1.5% by mass or less, even more preferably 1% by mass or less, even more preferably 0.5% by mass or less, even more preferably 0.2% by mass or less, even more preferably 0.1% by mass or less, and even more preferably 0.05% by mass or less, and may be substantially 0% by mass. Furthermore, from the viewpoint of obtaining bactericidal and / or antiviral activity and its sustained effect, the liquid composition used in the present invention preferably contains less than 2.0% by mass of triglycerides whose constituent fatty acids consist only of saturated fatty acids having 8 or more carbon atoms, more preferably 1.9% by mass or less, even more preferably 1.8% by mass or less, and especially preferably 1.5% by mass or less. Furthermore, from the viewpoint of obtaining bactericidal and / or antiviral activity and its sustained effect, the liquid composition used in the present invention preferably has a triglyceride content of less than 2.0% by mass, more preferably 1.9% by mass or less, even more preferably 1.8% by mass or less, and particularly preferably 1.5% by mass or less. Furthermore, the content of triglycerides, which consist only of saturated fatty acids with 8 or more carbon atoms as constituent fatty acids, and the content of triglycerides as described above also include the content of glyceryl trioctanoate.

[0017] The liquid composition used in the present invention preferably contains a low amount of oily components, from the viewpoint of obtaining bactericidal and / or antiviral activity and its sustained effect, without inhibiting contact between components (A) and (B) and bacteria and / or viruses. In the present invention, oily components refer to oils with a solubility of less than 0.01 g in 100 g of water at 20°C, and examples include silicone oil, ester oil, ether oil, hydrocarbon oil, fatty acids with 12 or more carbon atoms, and higher alcohols with 12 or more carbon atoms. The content of the oily component in the liquid composition used in the present invention is preferably 5% by mass or less, more preferably 4.5% by mass or less, more preferably 3% by mass or less, even more preferably less than 2% by mass, even more preferably 1.9% by mass or less, even more preferably 1.8% by mass or less, even more preferably 1.5% by mass or less, even more preferably 1% by mass or less, even more preferably 0.5% by mass or less, even more preferably 0.2% by mass or less, even more preferably 0.1% by mass or less, and even more preferably 0.05% by mass or less, and may be substantially 0% by mass. The above-mentioned oily component content also includes the content of glyceryl trioctanoate.

[0018] The target of sterilization and / or virus killing by the containerized liquid composition of the present invention is not particularly limited, but from the viewpoint of the high usefulness of the present invention, it is preferable that the target is skin, more preferably skin excluding the scalp. The liquid composition contained in a container used in the present invention is more preferably a leave-on topical skin preparation composition. In this specification, "leave-on topical skin preparation composition" means a topical skin preparation composition that is applied to the skin and used without being removed by washing with water or the like. The liquid composition used in the present invention can impart a bactericidal and / or antiviral effect to the skin surface by leaving components (A) and (B), which are bactericidal and / or antiviral components, on the skin surface. From the viewpoint of obtaining this effect, it is preferable that the liquid composition used in the present invention be left on the skin surface after application to the skin by coating or other means, without being removed by washing with water or the like. From the viewpoint of preventing contact transmission of bacteria or viruses, the liquid composition used in the present invention is more preferably a leave-on topical skin preparation composition for hands.

[0019] In this specification, "bactericidal and / or virucidal activity" means the bactericidal and / or virucidal activity possessed by the containerized liquid composition of the present invention and the liquid composition used therein. For example, the bactericidal activity against Serratia bacteria can be specifically evaluated by the method described in the examples. The activity against other bacteria and viruses can be evaluated with reference to common technical knowledge.

[0020] The bacteria or viruses that the containerized liquid composition of the present invention exhibits bactericidal and / or virucidal activity are not particularly limited as long as they are inactivated or killed upon contact with the liquid composition used in the present invention. For example, it is considered that microorganisms listed in the Ministry of Health, Labour and Welfare's guidelines for infectious disease control in childcare facilities can be used. Specifically, examples of bacteria include Gram-positive bacteria such as Bacillus anthrax, Mycobacterium tuberculosis, Streptococcus lyticus, Staphylococcus aureus, and Streptococcus pneumoniae, or Gram-negative bacteria such as Bacillus tularensis, Plague bacillus, Brucella, Glanders, Vibrio cholerae, Salmonella, Shigella, enterohemorrhagic Escherichia coli, and Bordetella pertussis. Examples of viruses include enveloped viruses such as arenavirus, Ebola virus, smallpox virus, nairovirus, Marburg virus, coronavirus, monkeypox virus, beta-coronavirus, influenza virus, RSV, herpesvirus, mumps virus, varicella-zoster virus, rubella virus, and measles virus, as well as non-enveloped viruses such as enterovirus, adenovirus, coxsackievirus, norovirus, and rotavirus. In this example, the bactericidal activity is evaluated using Serratia bacteria as an example, but the bacteria or viruses targeted by this invention are not limited to this.

[0021] <Component (A): Polyol> The component (A) used in the liquid composition is logP owIt is a polyol that satisfies the value ≥ -0.3. Component (A) itself acts as a bactericidal and / or virucidal component, and can suppress the decrease in the bactericidal and / or virucidal activity of component (B) by the above-mentioned mechanism of action.

[0022] The logP of component (A) ow The value is -0.3 or more, preferably 0.0 or more, more preferably 0.2 or more, and still more preferably 0.5 or more, from the viewpoints of bactericidal and / or virucidal activity and improvement of its sustained effect. logP ow This is because the larger the logP value, the higher the hydrophobicity of component (A), and it is considered that the effect of distorting or destroying the three-dimensional hydrogen bond network of water is easily obtained. On the other hand, from the viewpoint of preventing the percutaneous absorption of component (A) when the liquid composition is applied to the skin and enhancing the sustained effect of the bactericidal and / or virucidal activity, logP ow The value is preferably 2.0 or less, more preferably 1.0 or less, and still more preferably 0.7 or less. And the logP of component (A) ow The value is -0.3 or more, preferably 0.0 or more and 2.0 or less, more preferably 0.2 or more and 2.0 or less, still more preferably 0.2 or more and 1.0 or less, and even more preferably 0.5 or more and 0.7 or less. Here, P ow : The concentration ratio of component (A) in two solvent phases of 1-octanol and water when component (A) is added to the two solvent phases and reaches an equilibrium state logP ow = log 10 (Concentration of component (A) in 1-octanol phase / Concentration of component (A) in aqueous phase) is. The logP of component (A) ow The value can be obtained by calculating using the algorithm "XLOGP3" described in Renxiao Wang et al., J.Chem.Inf.Model.2007, Vol.47, pp.2140.

[0023] Component (A) has a hydrophilic portion consisting of a hydroxyl group and a hydrophobic portion containing a C atom. The (number of OH groups / number of C atoms) of component (A) is preferably less than 1, more preferably 0.95 or less, even more preferably 0.80 or less, even more preferably 0.70 or less, even more preferably 0.60 or less, even more preferably 0.50 or less, even more preferably 0.40 or less, even more preferably 0.35 or less, and also preferably 0.10 or more, more preferably 0.15 or more, and even more preferably 0.18 or more. Furthermore, the (number of OH groups / number of C atoms) of component (A) is preferably less than 1, more preferably 0.10 or more and 0.95 or less, even more preferably 0.15 or more and 0.80 or less, even more preferably 0.15 or more and 0.70 or less, even more preferably 0.15 or more and 0.60 or less, even more preferably 0.15 or more and 0.50 or less, even more preferably 0.15 or more and 0.40 or less, even more preferably 0.15 or more and 0.35 or less, and even more preferably 0.18 or more and 0.35 or less.

[0024] The carbon number of component (A) is preferably 4 or more from the viewpoint of improving bactericidal and / or antiviral activity and its sustained effect, and preferably 24 or less, more preferably 20 or less, even more preferably 16 or less, even more preferably 12 or less, even more preferably 11 or less, and even more preferably 8 or less from the viewpoint of improving bactericidal and / or antiviral activity by distorting or destroying the three-dimensional hydrogen bond network of water. Furthermore, the number of OH groups in component (A) is preferably 2 to 5, more preferably 2 to 4, and even more preferably 2 to 3, from the viewpoint of improving bactericidal and / or antiviral activity and its sustained effect.

[0025] Component (A) is measured in IR with absorbance on the vertical axis and wavenumber (cm) on the horizontal axis, from the viewpoint of improving bactericidal and / or antiviral activity and its sustained effect. -1 In this case, the wavenumber of the peak top originating from the OH stretching vibration is preferably 3300 cm⁻¹. -1More preferably 3318 cm -1 That's all, and normally it's 3452cm. -1 The reason is as follows: The higher the wavenumber at which the peak top frequency is located, the easier it is to distort or destroy the three-dimensional hydrogen bond network of water. The IR measurement of component (A) can be performed specifically by the method described in the examples.

[0026] Specific examples of component (A) include linear polyols and polyols having a cyclic structure, and any of these can be used. The term "linear" in linear polyols includes both straight chains and branched chains. Component (A) is preferably a linear polyol from the viewpoint of improving bactericidal and / or antiviral activity by distorting or disrupting the three-dimensional hydrogen bond network of water, more preferably a linear polyol having 4 or more carbon atoms from the viewpoint of improving bactericidal and / or antiviral activity by having a hydrophobic portion and from the viewpoint of sustained bactericidal and / or antiviral activity, and even more preferably a linear diol or linear triol having 4 or more carbon atoms. In addition, the bonding position of the OH group is not particularly limited in the chain-like polyol.

[0027] Examples of linear polyols used as component (A) include linear diols such as 2,3-butanediol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 2,5-hexanediol, 1,6-hexanediol, 1,2-heptanediol, 1,7-heptanediol, 1,2-octanediol, 1,8-octanediol, 1,2-nonanediol, 1,9-nonanediol, 1,2-decanediol, 1,10-decanediol, 1,2-dodecanediol, 1,12-dodecanediol, 1,2-tetradecanediol, 1,2-hexadecanediol, and 1,16-hexadecanediol; Linear triols such as 1,2,3-butanetriol, 1,2,4-butanetriol, 1,2,5-pentanetriol, 1,2,7-heptanetriol, 1,2,8-octantriol, 1,2,9-nonanetriol, and 1,2,10-decanetriol; Branched-chain diols or triols such as 2-methyl-1,3-propanediol, 2,2-dimethyl-1,3-propanediol, 3-methyl-1,3-butanediol, 2-methylpentane-2,4-diol, 2-ethyl-1,3-hexanediol, 2-butyl-2-ethyl-1,3-propanediol, 3-(2-ethylhexyloxy)-1,2-propanediol, (lauryl / myristyl) glycol hydroxypropyl ether, 3,7,11,15-tetramethylhexadecane-1,2,3-triol; and, Examples include polymers such as polyethylene glycol, polyglycerin, and PPG-10 butanediol; one or more of these can be used.

[0028] Among the above, from the viewpoint of improving bactericidal and / or antiviral activity and its sustained effect, component (A) is preferably one or more selected from the group consisting of 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2,10-decanetriol, 2-methylpentane-2,4-diol, 2-ethyl-1,3-hexanediol, and 3-(2-ethylhexyloxy)-1,2-propanediol, more preferably one or more selected from the group consisting of 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2,10-decanetriol, and 3-(2-ethylhexyloxy)-1,2-propanediol.

[0029] The content of component (A) in the liquid composition used in the present invention is 0.05% by mass or more, preferably 0.1% by mass or more, more preferably 0.2% by mass or more, even more preferably 0.3% by mass or more, even more preferably 0.5% by mass or more, and even more preferably 0.7% by mass or more, from the viewpoint of improving bactericidal and / or antiviral activity and its sustained effect. Furthermore, from the viewpoint of improving the feel of the composition, it is 30% by mass or less, preferably 20% by mass or less, more preferably 15% by mass or less, even more preferably 10% by mass or less, even more preferably 5.0% by mass or less, even more preferably 4.0% by mass or less, and even more preferably 3.0% by mass or less. Furthermore, the content of component (A) in the liquid composition used in the present invention is 0.05% by mass or more and 30% by mass or less, preferably 0.05% by mass or more and 20% by mass or less, more preferably 0.05% by mass or more and 15% by mass or less, even more preferably 0.05% by mass or more and 10% by mass or less, even more preferably 0.05% by mass or more and 5.0% by mass or less, even more preferably 0.1% by mass or more and 5.0% by mass or less, even more preferably 0.2% by mass or more and 5.0% by mass or less, even more preferably 0.3% by mass or more and 5.0% by mass or less, even more preferably 0.5% by mass or more and 5.0% by mass or less, even more preferably 0.5% by mass or more and 4.0% by mass or less, even more preferably 0.5% by mass or more and 3.0% by mass or less, and even more preferably 0.7% by mass or more and 3.0% by mass or less.

[0030] The liquid composition used in the present invention may contain, in addition to the above component (A), glycerin, etc., to the extent that it does not impair the effects of the present invention, logP owThe composition may also contain a polyol with a value of <-0.3 (hereinafter also referred to as "component (A')"). When the liquid composition used in the present invention contains component (A'), its content is preferably 0.025% by mass or more, more preferably 0.05% by mass or more, even more preferably 0.1% by mass or more, even more preferably 0.15% by mass or more, even more preferably 0.25% by mass or more, even more preferably 0.35% by mass or more, and even more preferably 0.5% by mass or more, from the viewpoint of moisturizing properties. Furthermore, from the viewpoint of improving the feel of the composition, it is preferably 10% by mass or less, more preferably 7.0% by mass or less, even more preferably 5.0% by mass or less, even more preferably 2.5% by mass or less, even more preferably 2.0% by mass or less, and even more preferably 1.5% by mass or less. Furthermore, the proportion of component (A) in the total polyol content of the liquid composition used in the present invention (component (A) content / total polyol content × 100 (mass%)) is preferably 50% by mass or more, more preferably 70% by mass or more, even more preferably 90% by mass or more, and 100% by mass or less.

[0031] <Ingredients (B): Disinfectants other than alcohol> The liquid composition used in the present invention contains a disinfectant other than an alcohol-based disinfectant as component (B). Suitable components (B) include one or more selected from the group consisting of cationic disinfectants, iodine-based disinfectants, phenol-based disinfectants, biguanide-based disinfectants, terpenoid-based disinfectants, chlorine-based disinfectants, and amphoteric surfactant-based disinfectants. These disinfectants are particularly suitable for use in skin topical formulations.

[0032] Cationic disinfectants include quaternary ammonium salt compounds such as cetylpyridinium chloride, benzethonium chloride, and benzalkonium chloride. Examples of iodine-based disinfectants include povidone-iodine, polyvinyl alcohol iodine, and cyclodextrin iodine. Examples of phenolic disinfectants include isopropylmethylphenol, triclosan, and phenoxyethanol. Examples of biguanide fungicides include chlorhexidine gluconate. Examples of terpenoid-based disinfectants include dipotassium glycyrrhizinate, stearyl glycyrrhetinate, and β-glycyrrhetinic acid. Examples of chlorine-based disinfectants include hypochlorous acid, sodium hypochlorite, calcium hypochlorite, and chlorinated isocyanuric acid. Examples of amphoteric surfactant-based disinfectants include alkyldiaminoethylglycine hydrochloride and alkylpolyaminoethylglycine.

[0033] Component (B) may consist of one or more types. Among the above, from the viewpoint of improving bactericidal and / or antiviral activity and its sustained effect, component (B) is preferably one or more selected from the group consisting of cationic bactericides, iodine-based bactericides, phenol-based bactericides, and biguanide-based bactericides, more preferably one or more selected from the group consisting of benzalkonium chloride, benzethonium chloride, povidone-iodine, and chlorhexidine gluconate, and even more preferably benzalkonium chloride.

[0034] The content of component (B) in the liquid composition used in the present invention is 0.01% by mass or more, preferably 0.02% by mass or more, and more preferably 0.03% by mass or more, from the viewpoint of bactericidal and / or antiviral activity and improvement of its sustained effect. Furthermore, from the viewpoint of suppressing skin irritation and economic efficiency, it is 10% by mass or less, preferably 5.0% by mass or less, more preferably 3.0% by mass or less, even more preferably 1.0% by mass or less, even more preferably 0.5% by mass or less, even more preferably 0.2% by mass or less, even more preferably 0.1% by mass or less, even more preferably 0.07% by mass or less, and even more preferably 0.05% by mass or less. Furthermore, the content of component (B) in the liquid composition used in the present invention is 0.01% by mass or more and 10% by mass or less, preferably 0.01% by mass or more and 8.0% by mass or less, more preferably 0.01% by mass or more and 5.0% by mass or less, even more preferably 0.01% by mass or more and 3.0% by mass or less, even more preferably 0.01% by mass or more and 1.0% by mass or less, even more preferably 0.02% by mass or more and 0.5% by mass or less, even more preferably 0.02% by mass or more and 0.2% by mass or less, even more preferably 0.03% by mass or more and 0.1% by mass or less, even more preferably 0.03% by mass or more and 0.07% by mass or less, and even more preferably 0.03% by mass or more and 0.05% by mass or less.

[0035] The mass ratio (B / A) of component (B) to component (A) in the liquid composition used in the present invention is preferably 0.001 or higher, more preferably 0.005 or higher, and even more preferably 0.01 or higher, from the viewpoint of improving bactericidal and / or antiviral activity and its sustained effect. Furthermore, from the viewpoint of suppressing skin irritation and economic efficiency, it is preferably 5 or lower, more preferably 1 or lower, and even more preferably 0.1 or lower. In addition, the mass ratio (B / A) of component (B) to component (A) in the liquid composition used in the present invention is preferably 0.001 or higher and 5 or lower, more preferably 0.005 or higher and 1 or lower, and even more preferably 0.01 or higher and 0.1 or lower.

[0036] The liquid composition used in the present invention may contain an alcohol-based disinfectant, to the extent that it does not impair the effects of the present invention. When the liquid composition used in the present invention contains an alcohol-based disinfectant, its content is preferably 1% by mass or more, more preferably 5% by mass or more, and even more preferably 10% by mass or more, from the viewpoint of bactericidal and / or antiviral activity. Furthermore, from the viewpoint of suppressing skin irritation, it is preferably 80% by mass or less, more preferably 70% by mass or less, even more preferably 50% by mass or less, even more preferably 20% by mass or less, even more preferably 10% by mass or less, even more preferably 3% by mass or less, even more preferably 1% by mass or less, even more preferably 0.07% by mass or less, even more preferably 0.05% by mass or less, even more preferably 0.03% by mass or less, and even more preferably less than 0.01% by mass, with the most preferable being substantially 0% by mass.

[0037] <Water> The liquid composition used in the present invention preferably further contains water, from the viewpoint of dissolving component (A) and component (B), and from the viewpoint of making it easy to apply to objects such as the skin surface. The water content in the liquid composition used in the present invention is preferably 10% by mass or more, more preferably 50% by mass or more, even more preferably 70% by mass or more, and also preferably 99.45% by mass or less.

[0038] The total content of component (A), component (B), and water in the liquid composition used in the present invention is preferably 25% by mass or more, more preferably 50% by mass or more, even more preferably 70% by mass or more, even more preferably 90% by mass or more, and even more preferably 95% by mass or more, and may be substantially 100% by mass.

[0039] The liquid composition contained in the container used in the present invention may further contain one or more components selected from the group consisting of the following components (C) and (D), with respect to the viewpoint of improving bactericidal and / or antiviral activity and its sustained effect. Ingredient (C): One or more surfactants selected from the group consisting of nonionic surfactants and anionic surfactants. Ingredient (D): Organic acid or its salt

[0040] <Ingredients (C): Surfactants> Component (C) is one or more surfactants selected from the group consisting of nonionic surfactants and anionic surfactants. Examples of nonionic surfactants include polyoxyethylene alkyl ethers, polyoxyethylene alkenyl ethers, sucrose fatty acid esters, polyoxyethylene fatty acid esters, polyglyceryl alkyl ethers, fatty acid polyglyceryls, sorbitan fatty acid esters, alkyl glucosides, polyoxyethylene alkylamines, polyoxyethylene sorbitan fatty acid esters, and polyoxyethylene sorbitan fatty acid esters. One or more of these can be used.

[0041] Of the above, the alkyl groups in polyoxyethylene alkyl ethers, polyglyceryl alkyl ethers, alkyl glucosides, and polyoxyethylene alkylamines, the alkenyl groups in polyoxyethylene alkenyl ethers, and the fatty acids in sucrose fatty acid esters, polyoxyethylene fatty acid esters, fatty acid polyglyceryls, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, and polyoxyethylene sorbitan fatty acid esters are preferably having 8 to 22 carbon atoms, more preferably 10 to 22 carbon atoms, and even more preferably 10 to 18 carbon atoms, from the viewpoint of improving bactericidal and / or antiviral activity and its sustained effect.

[0042] Furthermore, the average number of moles of oxyethylene groups added in polyoxyethylene alkyl ethers, polyoxyethylene alkenyl ethers, polyoxyethylene fatty acid esters, polyoxyethylene alkylamines, polyoxyethylene sorbitan fatty acid esters, and polyoxyethylene sorbitan fatty acid esters (hereinafter referred to as "average number of moles of EO added") is preferably 2 or more, more preferably 3 or more, and also preferably 20 or less, more preferably 15 or less, and even more preferably 10 or less, from the viewpoint of improving bactericidal and / or antiviral activity and its sustained effect. The above average number of moles of EO added is preferably 2 to 20, more preferably 3 to 20, even more preferably 3 to 15, and even more preferably 3 to 10. Note that the average number of moles of EO added is a number average value.

[0043] Examples of anionic surfactants include alkylbenzene sulfonates, alkyl or alkenyl ether sulfates, alkyl or alkenyl sulfates, alkyl sulfonates, saturated or unsaturated fatty acid salts, alkyl or alkenyl ether carboxylates, α-sulfo fatty acid salts, N-acyl amino acids, phosphate mono or diesters, sulfosuccinates, etc., and one or more of these can be used. Examples of counterions for the anionic group in anionic surfactants include alkali metal ions such as sodium ions and potassium ions; alkaline earth metal ions such as calcium ions and magnesium ions; ammonium ions; and alkanolammonium (e.g., monoethanolammonium, diethanolammonium, triethanolammonium, triisopropanolammonium, etc.) which have 1 to 3 alkanol groups with 2 or 3 carbon atoms. Among the above, one or more selected from the group consisting of alkyl sulfates, alkyl ether sulfates, and alkyl ether carboxylates are preferred. Examples of alkyl ether sulfates include polyoxyethylene alkyl ether sulfates such as sodium laureth sulfate, and examples of alkyl ether carboxylates include polyoxyethylene alkyl ether acetates such as sodium laureth acetate.

[0044] Component (C) may consist of one or more types. Among the above, from the viewpoint of improving bactericidal and / or antiviral activity and its sustained effect, nonionic surfactants are preferred as component (C), more preferably one or more selected from the group consisting of polyoxyethylene alkyl ethers, polyoxyethylene alkenyl ethers, sucrose fatty acid esters, polyoxyethylene fatty acid esters, polyglyceryl alkyl ethers, fatty acid polyglyceryls, alkyl glucosides, and polyoxyethylene alkylamines, even more preferably one or more selected from the group consisting of polyoxyethylene alkyl ethers, polyoxyethylene alkenyl ethers, and polyoxyethylene fatty acid esters, and even more preferably polyoxyethylene alkyl ethers.

[0045] When the liquid composition used in the present invention contains component (C), the content of component (C) in the liquid composition is preferably 0.01% by mass, more preferably 0.05% by mass or more, even more preferably 0.1% by mass or more, even more preferably 0.2% by mass or more, and even more preferably 0.3% by mass or more, from the viewpoint of improving bactericidal and / or antiviral activity and its sustained effect. Furthermore, from the viewpoint of improving the suppression of skin irritation and economic efficiency, it is preferably 5.0% by mass or less, more preferably 3.0% by mass or less, and even more preferably 1.0% by mass or less. The content of component (C) in the liquid composition used in the present invention is preferably 0.01% by mass or more and 5.0% by mass or less, more preferably 0.05% by mass or more and 3.0% by mass or less, even more preferably 0.1% by mass or more and 3.0% by mass or less, even more preferably 0.2% by mass or more and 3.0% by mass or less, and even more preferably 0.3% by mass or more and 1.0% by mass or less. Furthermore, if the liquid composition used in the present invention contains an anionic surfactant as component (C), its content is quantified according to the dissociation state of the anionic surfactant in the liquid composition. For example, if the anionic surfactant exists in the liquid composition in a dissociated form, the amount is quantified as the amount in the dissociated form.

[0046] <Component (D): Organic acid or its salt> Examples of organic acids used as component (D) include lactic acid, pyruvic acid, urocanic acid, acetic acid, glycolic acid, malic acid, tartaric acid, citric acid, succinic acid, fumaric acid, and adipic acid, and one or more of these can be used. From the viewpoint of improving bactericidal and / or antiviral activity, as well as its sustained effect, and from the viewpoint of low skin irritation, one or more selected from the group consisting of lactic acid, pyruvic acid, and urocanic acid are preferred as component (D). Examples of salts of lactic acid, pyruvic acid, and urocanic acid include alkali metal salts of lactic acid or pyruvic acid such as potassium salts and sodium salts; alkaline earth metal salts of lactic acid or pyruvic acid such as calcium salts and magnesium salts; amine salts; and ammonium salts. Among these, from the viewpoint of improving bactericidal and / or antiviral activity, and from the viewpoint of availability, one or more selected from the group consisting of alkali metal salts and alkaline earth metal salts of lactic acid, pyruvic acid, and urocanic acid are preferred, one or more selected from the group consisting of potassium salts, sodium salts, and calcium salts are more preferred, and one or more selected from the group consisting of potassium lactate, sodium lactate, and calcium lactate are even more preferred. From the viewpoint of improving bactericidal and / or antiviral activity and its sustained effect, component (D) is more preferably lactic acid or a salt thereof, more preferably one or more selected from the group consisting of lactic acid, potassium lactate, sodium lactate, and calcium lactate, and more preferably lactic acid.

[0047] When the liquid composition used in the present invention contains component (D), the content of component (D) in the liquid composition is preferably 0.1% by mass or more, more preferably 0.3% by mass or more, and even more preferably 0.5% by mass or more, from the viewpoint of improving bactericidal and / or antiviral activity and its sustained effect. Furthermore, from the viewpoint of suppressing skin irritation and economic efficiency, it is preferably 10.0% by mass or less, more preferably 5.0% by mass or less, even more preferably 3.0% by mass or less, and even more preferably 2.0% by mass or less. And the content of component (D) in the liquid composition used in the present invention is preferably 0.1% by mass or more and 10.0% by mass or less, more preferably 0.3% by mass or more and 5.0% by mass or less, even more preferably 0.3% by mass or more and 3.0% by mass or less, and even more preferably 0.5% by mass or more and 2.0% by mass or less. In this specification, if component (D) includes a salt, "content of component (D)" means the amount converted to acid.

[0048] The total content of component (C) and component (D) in the liquid composition used in the present invention is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, even more preferably 0.2% by mass or more, and even more preferably 0.3% by mass or more, from the viewpoint of bactericidal and / or antiviral activity and improvement of its sustained effect, and preferably 15% by mass or less, more preferably 12% by mass or less, even more preferably 10% by mass or less, even more preferably 5.0% by mass or less, and even more preferably 3.0% by mass or less, from the viewpoint of suppressing skin irritation and economic efficiency. Furthermore, the total content of component (C) and component (D) in the liquid composition used in the present invention is preferably 0.01% by mass or more and 15% by mass or less, more preferably 0.1% by mass or more and 12% by mass or less, even more preferably 0.2% by mass or more and 10% by mass or less, even more preferably 0.3% by mass or more and 5.0% by mass or less, and even more preferably 0.3% by mass or more and 3.0% by mass or less.

[0049] <Other ingredients> In addition to the above, the liquid composition used in the present invention may also contain other components as needed, such as thickeners, pH adjusters (hydrochloric acid, sodium hydroxide, etc.), UV absorbers, antioxidants, preservatives, antiperspirants, fragrances, moisturizers, texture modifiers, anti-inflammatory agents, etc.

[0050] The liquid composition used in the present invention preferably has a low zinc content. This is because zinc inhibits the bactericidal properties of component (B) (especially benzalkonium chloride). More specifically, the zinc content in the liquid composition used in the present invention is preferably 0.2% by mass or less, more preferably 0.1% by mass or less, even more preferably 0.01% by mass or less, and even more preferably substantially 0% by mass, as the amount of zinc salt. From the same viewpoint as described above, the total amount of divalent and trivalent metal ions in the liquid composition used in the present invention is preferably 0.2% by mass or less, more preferably 0.1% by mass or less, even more preferably 0.01% by mass or less, and even more preferably substantially 0% by mass.

[0051] <ph> The liquid composition used in the present invention has a pH of 3.5 or higher, preferably 3.7 or higher, and more preferably 4.0 or higher, from the viewpoint of suppressing skin irritation. Furthermore, from the viewpoint of improving bactericidal and / or antiviral activity and its sustained effect, the pH is 7.0 or lower, preferably 6.0 or lower, more preferably 5.5 or lower, even more preferably 5.0 or lower, and even more preferably 4.5 or lower. The specific range of pH for the liquid composition used in the present invention is 3.5 or higher and 7.0 or lower, preferably 3.7 or higher and 6.0 or lower, more preferably 3.7 or higher and 5.5 or lower, even more preferably 4.0 or higher and 5.0 or lower, and even more preferably 4.0 or higher and 4.5 or lower. The above pH values ​​are those at 25°C, and can be measured specifically by the method described in the examples.

[0052] The liquid composition used in the present invention only needs to be fluid at 25°C. The form of the liquid composition is not particularly limited and can be, for example, liquid, gel, or cream. From the viewpoint of ease of application to the skin, the form of the composition of the present invention is preferably gel or cream. The liquid composition may also be in the form of an emulsion, and the emulsion may be either an oil-in-water emulsion or an oil-in-water emulsion.

[0053] From the viewpoint of preventing contact infection by bacteria or viruses, the liquid composition used in the present invention is preferably a topical skin preparation composition for hands among topical skin preparation compositions. Furthermore, from the viewpoint of preventing contact infection by bacteria or viruses, the packaged liquid composition of the present invention is preferably a packaged liquid topical skin preparation composition for hands among packaged liquid topical skin preparation compositions. Examples of product forms include hand sanitizers and hand cream cosmetics.

[0054] [Defense method] The present invention also provides a method for protecting skin from bacteria or viruses (hereinafter also referred to as "the method of the present invention"), comprising the step of applying the liquid composition contained in the container to the skin. According to the method of the present invention, the skin can be protected from bacteria or viruses. The bacteria or viruses that are protected by the method of the present invention are the same as described above. The method of applying the liquid composition to the skin can be appropriately selected depending on the application site, etc. For example, the liquid composition contained in a container can be applied to the skin surface by rubbing, spraying, etc.

[0055] In this specification, "protecting the skin from bacteria or viruses" encompasses the concept of providing: (1) a bactericidal and antiviral effect exhibited against bacteria and viruses attached to the skin surface after the composition has been applied to the skin surface; (2) a bactericidal and antiviral effect exhibited against bacteria and viruses attached to the skin by applying the composition; (3) an effect of preparing the skin to be free from the transmission of bacteria and viruses; (4) an effect of protecting the skin from bacteria and viruses and keeping it hygienic; (5) an effect of preventing the transmission of bacteria and viruses through the skin and contact infection; and (6) an effect of enhancing the skin's ability to protect against infection by bacteria and viruses.

[0056] In the method of the present invention, it is preferable not to remove the liquid composition by washing with water or the like after applying it to the skin, but to leave it on the skin surface. This is because by using the liquid composition as a leave-on topical skin preparation composition, the bactericidal and / or antiviral components (A) and (B) can remain on the skin surface, thereby imparting a bactericidal and / or antiviral effect to the skin surface.

[0057] In this process, the amount of the liquid composition applied is not particularly limited as long as it is sufficient to impart bactericidal and / or antiviral activity to the skin surface. From the viewpoint of providing high bactericidal and / or antiviral activity and its persistence, in the process, the amount of the liquid composition applied is such that the amount of component (A) is equal to the amount of skin per 1 cm 2 The amount per 1 cm of skin is preferably 0.0005 mg or more, more preferably 0.001 mg or more, even more preferably 0.002 mg or more, even more preferably 0.005 mg or more, even more preferably 0.01 mg or more, and even more preferably 0.02 mg or more. Furthermore, from the viewpoint of improving usability and economic efficiency, the amount is preferably 1.0 mg or less, more preferably 0.5 mg or less, and even more preferably 0.2 mg or less. The amount of the composition to be applied is such that the amount of component (A) per 1 cm of skin 2 The amount is preferably 0.0005 mg to 1.0 mg per serving, more preferably 0.001 mg to 1.0 mg, even more preferably 0.002 mg to 1.0 mg, even more preferably 0.005 mg to 1.0 mg, even more preferably 0.01 mg to 0.5 mg, and even more preferably 0.02 mg to 0.2 mg.

[0058] The liquid composition may be applied to skin that has been pre-washed with water, soap, body wash, hand soap, etc., or it may be applied to unwashed skin. Since the skin after washing has had naturally present components such as lactic acid washed away, and its ability to defend against bacteria and viruses in the outside world is reduced, it is more preferable to apply the liquid composition to the skin after washing and then carry out the method of the present invention.

[0059] [use] The present invention also provides logP for enhancing or prolonging the bactericidal effect of a non-alcohol-based disinfectant (B) on the skin. ow This provides the use of polyol (A) satisfying the value ≥ -0.3. The specific polyol (A) described above, when used in combination with the disinfectant (B) described above, can enhance or prolong the bactericidal effect on the skin based on the mechanism of action described above. In the above, the bactericide (B), polyol (A), and preferred embodiments thereof are the same as those described above for component (B) and component (A), respectively.

[0060] The present invention further, Component (A):logP ow One or more polyols satisfying a value ≥ -0.3, Ingredients (B): Disinfectants other than alcohol-based disinfectants, The invention also provides a liquid composition containing the above, wherein the content of component (A) is 0.05% by mass or more and 30% by mass or less, the content of component (B) is 0.01% by mass or more and 10% by mass or less, the content of glycerin trioctanoate is less than 2% by mass, and the pH at 25°C is 3.5 or more and 7.0 or less, for use as a topical skin preparation composition for bactericidal and / or antiviral purposes. In the above, component (A) and component (B), and preferred embodiments thereof, are the same as described above.

[0061] With regard to the embodiments described above, the present invention further discloses the following. <1> Component (A):logP ow One or more polyols satisfying a value ≥ -0.3, and Ingredients (B): Disinfectants other than alcohol-based disinfectants, It contains, The content of component (A) is 0.05% by mass or more and 30% by mass or less. The content of component (B) is 0.01% by mass or more and 10% by mass or less. A containerized liquid composition comprising a liquid composition containing less than 2% by mass of glycerin trioctanoate and having a pH of 3.5 or higher and 7.0 or lower at 25°C, contained in a container. <2> logP of component (A) ow The value is preferably 0.0 or more and 2.0 or less, more preferably 0.2 or more and 2.0 or less, even more preferably 0.2 or more and 1.0 or less, and even more preferably 0.5 or more and 0.7 or less. <1> The containerized liquid composition described above. <3> The (number of OH groups / number of C atoms) of component (A) is preferably less than 1, more preferably 0.10 or more and 0.95 or less, even more preferably 0.15 or more and 0.80 or less, even more preferably 0.15 or more and 0.70 or less, even more preferably 0.15 or more and 0.60 or less, even more preferably 0.15 or more and 0.50 or less, even more preferably 0.15 or more and 0.40 or less, even more preferably 0.15 or more and 0.35 or less, and even more preferably 0.18 or more and 0.35 or less. <1> The containerized liquid composition described above. <4> In the IR measurement of component (A), the vertical axis represents absorbance and the horizontal axis represents wavenumber (cm²). -1 In this case, the wavenumber of the peak top originating from the OH stretching vibration is preferably 3300 cm⁻¹. -1 More preferably 3318 cm -1 That's all. 3452cm -1 The following is: <1> or <2> The containerized liquid composition described above. <5> The number of OH groups in component (A) is preferably 2 to 5, more preferably 2 to 4, and even more preferably 2 to 3. <1> ~ <4> A containerized liquid composition according to any one of the following. <6> Component (A) is a linear polyol having 4 or more carbon atoms, preferably a linear diol or linear triol having 4 or more carbon atoms. <1> ~ <5> A containerized liquid composition according to any one of the following. <7> Component (A) is preferably one or more selected from the group consisting of 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2,10-decanetriol, 2-methylpentane-2,4-diol, 2-ethyl-1,3-hexanediol, and 3-(2-ethylhexyloxy)-1,2-propanediol, more preferably one or more selected from the group consisting of 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2,10-decanetriol, and 3-(2-ethylhexyloxy)-1,2-propanediol. <1> ~ <6> A containerized liquid composition according to any one of the following. <8> The content of component (A) in the liquid composition is 0.05% by mass or more and 30% by mass or less, preferably 0.05% by mass or more and 20% by mass or less, more preferably 0.05% by mass or more and 15% by mass or less, even more preferably 0.05% by mass or more and 10% by mass or less, even more preferably 0.05% by mass or more and 5.0% by mass or less, even more preferably 0.1% by mass or more and 5.0% by mass or less, even more preferably 0.2% by mass or more and 5.0% by mass or less, even more preferably 0.3% by mass or more and 5.0% by mass or less, even more preferably 0.5% by mass or more and 5.0% by mass or less, even more preferably 0.5% by mass or more and 4.0% by mass or less, even more preferably 0.5% by mass or more and 3.0% by mass or less, and even more preferably 0.7% by mass or more and 3.0% by mass or less. <1> ~ <7> A containerized liquid composition according to any one of the following. <9> In the liquid composition, the proportion of component (A) in the total polyol is preferably 50% by mass or more, more preferably 70% by mass or more, even more preferably 90% by mass or more, and 100% by mass or less. <1> ~ <8> A containerized liquid composition according to any one of the following. <10> Component (B) is one or more selected from the group consisting of cationic disinfectants, iodine-based disinfectants, phenol-based disinfectants, biguanide-based disinfectants, terpenoid-based disinfectants, chlorine-based disinfectants, and amphoteric surfactant-based disinfectants, preferably one or more selected from the group consisting of cationic disinfectants, iodine-based disinfectants, phenol-based disinfectants, and biguanide-based disinfectants, more preferably one or more selected from the group consisting of benzalkonium chloride, benzethonium chloride, povidone-iodine, and chlorhexidine gluconate, and even more preferably benzalkonium chloride. <1> ~ <9> A containerized liquid composition according to any one of the following.

[0062] <11> The content of component (B) in the liquid composition is preferably 0.01% by mass or more and 8.0% by mass or less, more preferably 0.01% by mass or more and 5.0% by mass or less, even more preferably 0.01% by mass or more and 3.0% by mass or less, even more preferably 0.01% by mass or more and 1.0% by mass or less, even more preferably 0.02% by mass or more and 0.5% by mass or less, even more preferably 0.02% by mass or more and 0.2% by mass or less, even more preferably 0.03% by mass or more and 0.1% by mass or less, even more preferably 0.03% by mass or more and 0.07% by mass or less, and even more preferably 0.03% by mass or more and 0.05% by mass or less. <1> ~ <10> A containerized liquid composition according to any one of the following. <12> The mass ratio (B / A) of component (B) to component (A) in the liquid composition is preferably 0.001 or more and 5 or less, more preferably 0.005 or more and 1 or less, and even more preferably 0.01 or more and 0.1 or less. <1> ~ <11> A containerized liquid composition according to any one of the following. <13> The liquid composition further contains water, and the water content in the liquid composition is preferably 10% by mass or more and 99.45% by mass or less, more preferably 50% by mass or more and 99.45% by mass or less, and even more preferably 70% by mass or more and 99.45% by mass or less. <1> ~ <12> A containerized liquid composition according to any one of the following. <14> The total content of component (A), component (B), and water in the liquid composition is preferably 25% by mass or more, more preferably 50% by mass or more, even more preferably 70% by mass or more, even more preferably 90% by mass or more, and even more preferably 95% by mass or more. <1> ~ <13> A containerized liquid composition according to any one of the following. <15> Furthermore, the liquid composition contained in the container contains one or more selected from the group consisting of the following components (C) and (D). <1> ~ <14> A containerized liquid composition according to any one of the following. Ingredient (C): One or more surfactants selected from the group consisting of nonionic surfactants and anionic surfactants. Ingredient (D): Organic acid or its salt <16> Component (C) is preferably a nonionic surfactant, more preferably one or more selected from the group consisting of polyoxyethylene alkyl ethers, polyoxyethylene alkenyl ethers, sucrose fatty acid esters, polyoxyethylene fatty acid esters, polyglyceryl alkyl ethers, fatty acid polyglyceryls, alkyl glucosides, and polyoxyethylene alkylamines, even more preferably one or more selected from the group consisting of polyoxyethylene alkyl ethers, polyoxyethylene alkenyl ethers, and polyoxyethylene fatty acid esters, and even more preferably a polyoxyethylene alkyl ether. <15> The containerized liquid composition described above. <17> The content of component (C) in the liquid composition is preferably 0.01% by mass or more and 5.0% by mass or less, more preferably 0.05% by mass or more and 3.0% by mass or less, even more preferably 0.1% by mass or more and 3.0% by mass or less, even more preferably 0.2% by mass or more and 3.0% by mass or less, and even more preferably 0.3% by mass or more and 1.0% by mass or less. <15> or <16> The containerized liquid composition described above. <18> The organic acid used as component (D) is one or more selected from the group consisting of lactic acid, pyruvic acid, urocanic acid, acetic acid, glycolic acid, malic acid, tartaric acid, citric acid, succinic acid, fumaric acid, and adipic acid, preferably one or more selected from the group consisting of lactic acid, pyruvic acid, and urocanic acid. <15> ~ <17> A containerized liquid composition according to any one of the following. <19> Component (D) is lactic acid or a salt thereof, preferably one or more selected from the group consisting of lactic acid, potassium lactate, sodium lactate, and calcium lactate, more preferably lactic acid. <18> The containerized liquid composition described above. <20> The content of component (D) in the liquid composition is preferably 0.1% by mass or more and 10.0% by mass or less, more preferably 0.3% by mass or more and 5.0% by mass or less, even more preferably 0.3% by mass or more and 3.0% by mass or less, and even more preferably 0.5% by mass or more and 2.0% by mass or less. <15> ~ <19> A containerized liquid composition according to any one of the following.

[0063] <21> The total content of component (C) and component (D) in the liquid composition is preferably 0.01% by mass or more and 15% by mass or less, more preferably 0.1% by mass or more and 12% by mass or less, even more preferably 0.2% by mass or more and 10% by mass or less, even more preferably 0.3% by mass or more and 5.0% by mass or less, and even more preferably 0.3% by mass or more and 3.0% by mass or less. <15> ~ <20> A containerized liquid composition according to any one of the following. <22> The pH of the liquid composition at 25°C is preferably 3.7 to 6.0, more preferably 3.7 to 5.5, even more preferably 4.0 to 5.0, and even more preferably 4.0 to 4.5. <1> ~ <21> A containerized liquid composition according to any one of the following. <23> The content of glycerin trioctanoate in the liquid composition is preferably 1.9% by mass or less, more preferably 1.8% by mass or less, even more preferably 1.5% by mass or less, even more preferably 1% by mass or less, even more preferably 0.5% by mass or less, even more preferably 0.2% by mass or less, even more preferably 0.1% by mass or less, even more preferably 0.05% by mass or less, and even more preferably substantially 0% by mass. <1> ~ <22> A containerized liquid composition according to any one of the following. <24> The content of triglycerides in the liquid composition, consisting solely of saturated fatty acids with 8 or more carbon atoms, is preferably less than 2.0% by mass, more preferably 1.9% by mass or less, even more preferably 1.8% by mass or less, and even more preferably 1.5% by mass or less. <1> ~ <23> A containerized liquid composition according to any one of the following. <25> The triglyceride content in the liquid composition is preferably less than 2.0% by mass, more preferably 1.9% by mass or less, even more preferably 1.8% by mass or less, and even more preferably 1.5% by mass or less. <1> ~ <24> A containerized liquid composition according to any one of the following. <26> The content of oily components in the liquid composition is preferably 5% by mass or less, more preferably 4.5% by mass or less, more preferably 3% by mass or less, even more preferably less than 2% by mass, even more preferably 1.9% by mass or less, even more preferably 1.8% by mass or less, even more preferably 1.5% by mass or less, even more preferably 1% by mass or less, even more preferably 0.5% by mass or less, even more preferably 0.2% by mass or less, even more preferably 0.1% by mass or less, even more preferably 0.05% by mass or less, and even more preferably substantially 0% by mass. <1> ~ <25> A containerized liquid composition according to any one of the following. <27> The liquid composition contained in the container is a leave-on topical skin preparation composition, preferably a leave-on topical skin preparation composition for the hands. <1> ~ <26> A containerized liquid composition according to any one of the following. <28> <1> ~ <27> A method for protecting skin from bacteria or viruses, comprising the step of applying a liquid composition contained in a container to the skin, using a liquid composition in a container as described in any one of the above. <29> In the process of applying the liquid composition to the skin, the amount of the containerized liquid composition applied is such that the amount of component (A) is such that the amount of skin is such that the amount of component (A) 2 The amount is preferably 0.0005 mg to 1.0 mg per unit, more preferably 0.001 mg to 1.0 mg, even more preferably 0.002 mg to 1.0 mg, even more preferably 0.005 mg to 1.0 mg, even more preferably 0.01 mg to 0.5 mg, and even more preferably 0.02 mg to 0.2 mg. <28> Methods used. <30> Apply the liquid composition from the container to the skin after washing. <28> or <29> Methods used.

[0064] <31> logP for enhancing or prolonging the bactericidal effect of non-alcohol-based disinfectants (B) on the skin. ow Use of polyol (A) satisfying the value ≥ -0.3. <32> Component (A):logP ow One or more polyols satisfying a value ≥ -0.3, and Ingredients (B): Disinfectants other than alcohol-based disinfectants, Use of a liquid composition containing the following, wherein the content of component (A) is 0.05% by mass or more and 30% by mass or less, the content of component (B) is 0.01% by mass or more and 10% by mass or less, the content of glycerin trioctanoate is less than 2% by mass, and the pH at 25°C is 3.5 or more and 7.0 or less, as a topical skin preparation composition for bactericidal and / or antiviral purposes. [Examples]

[0065] The present invention will be described below with reference to examples, but the present invention is not limited to the scope of these examples. In these examples, various measurements and evaluations were performed by the following methods.

[0066] (pH) The pH of the liquid composition was measured at 25°C using a pH meter (electrode 6367-10D (manufactured by Horiba, Ltd.)).

[0067] (IR measurement) The polyols listed in Table 1 were used as measurement samples, and IR measurements were performed using the ATR method with an infrared spectrophotometer (PerkinElmer "Spectrum 400, Universal ATR unit"). Diamond / ZnSe was used as the crystal, with a resolution of 4 cm. -1 With a cumulative total of 16 runs, the distance covered was 4000-650 cm. -1 Measurements were taken within the specified range. The measurements were performed in an environment with a room temperature of 22°C and a humidity of 35%RH. The vertical axis of the chart represents absorbance, and the horizontal axis represents wavenumber (cm²). -1 ) as, 3250~3452cm -1 The wavenumber of the peak top in the range is the wavenumber of the OH stretching vibration (cm -1 ) are shown in Table 1.

[0068] (logP ow value) logP of polyols listed in Table 1 ow The values ​​are taken from the chemical substance database "PubChem" and calculated using the aforementioned algorithm "XLOGP3".

[0069] (Preparation of bacterial suspension) For the evaluation of bactericidal activity, a bacterial suspension of Serratia bacteria prepared by the following method was used. The Serratia strain used was NBRC12648. This bacterium was cultured in LB liquid medium, the cells were collected by centrifugation, and then purified with distilled water (OD). 600 I adjusted it so that it equals 10. (Bactericidal activity evaluation) [a. Bactericidal activity of the liquid composition immediately after application (logarithmic decrease value)] The inner forearm of the subjects was washed with Biore u Rg (manufactured by Kao Corporation). After waiting 5-10 minutes, the liquid compositions described in Tables 2-6 were applied to the skin surface (7.5 cm) of the inner forearm. 2 In the range of Comparative Examples 2 and 3, the product was applied to a stainless steel surface and a glass surface, respectively, and coated uniformly to achieve the application amount shown in each table. After standing for 5 minutes and drying, a fixed amount (7.5 μL / 7.5 cm) of the Serratia bacterium solution prepared by the above method is applied to the skin surface after application of the liquid composition. 2 The solution was then applied uniformly. After standing for a predetermined time (indicated as "contact time with bacteria" in the table), the applied bacterial solution was collected using two swabs. Next, the number of viable bacteria was measured using the incubation reader "HiTS" (manufactured by Cynics Co., Ltd.) according to the following method, and the amount of decrease in bacterial count (number of viable bacteria / initial number of viable bacteria) was confirmed. Liquid cultures were performed at 37°C in the incubation leader "HiTS," and the absorbance (turbidity) at a wavelength of 600 nm was measured over time to create growth curves for the number of viable bacteria in the bacterial suspension. Simultaneously, bacterial suspensions with known viable bacterial counts were serially diluted, and culture and growth curves were created in the same manner to create calibration curves between the time to reach a certain turbidity and the number of viable bacteria. From the relationship between the time to reach a certain turbidity and the calibration curve for each sample, the number of viable bacteria in the recovered bacterial suspension was estimated, and the amount of decrease in bacterial count was confirmed. The degree of reduction in bacterial count (logarithmic reduction) was measured by taking the -log value of the above bacterial count reduction and is shown in Tables 2-6 as "Evaluation Result a". A larger value indicates higher bactericidal activity.

[0070] [b. Bactericidal activity (logarithmic decrease) after the evaluation period for the sustained effectiveness of the liquid composition] In step a. above, the procedure was the same as in step a. above, except that the standing time (5 minutes) after applying the liquid composition listed in Table 3 to the target object was changed to the "standing time for evaluating persistence" listed in each table. For the degree of reduction in bacterial count (logarithmic reduction value), the -log value of the bacterial count reduction was taken and is shown in Table 3 as "Evaluation Result b". A larger value indicates higher bactericidal activity.

[0071] [c. Bactericidal activity (logarithmic decrease value) immediately after application of a liquid composition (pure water) without added ingredients] The bactericidal activity was evaluated using pure water instead of the compositions listed in Tables 2-6, in the same manner as in a. above (evaluation result c).

[0072] [d. Bactericidal activity (logarithmic decrease value) after the duration of evaluation of the sustained effect of a liquid composition (pure water) without added ingredients] The bactericidal activity was evaluated using pure water instead of the compositions listed in Table 3, in the same manner as in c. above (evaluation result d).

[0073] Furthermore, the difference between evaluation results a and c (ac), and the difference between evaluation results b and d (bd) were calculated and shown in Tables 2-6. A larger value of (ac) indicates a higher bactericidal effect immediately after application of the liquid composition (initial stage), and a larger value of (bd) indicates a higher bactericidal effect even after time has passed since application of the liquid composition.

[0074] Examples 1-15, Comparative Examples 1-9 (Preparation and Evaluation of Liquid Compositions) The amounts of each component shown in Tables 2-6 were combined and mixed at room temperature. Then, the pH was adjusted to the levels indicated in each table using a 1 mol / L aqueous hydrochloric acid solution (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) and / or a 1 mol / L aqueous sodium hydroxide solution (manufactured by Fujifilm Wako Pure Chemical Industries, Ltd.) as pH adjusters to prepare the liquid compositions. The amounts listed in Tables 2-6 represent the amount of active ingredient (mass%) of each component. The bactericidal activity of the obtained liquid composition was evaluated using the method described above. The results are shown in Tables 2 to 6. Details of component (A) used in Tables 2 to 6, and component (A'), which is a polyol not corresponding to component (A), are shown in Table 1.

[0075] [Table 1]

[0076] [Table 2]

[0077] [Table 3]

[0078] [Table 4]

[0079] [Table 5]

[0080] [Table 6]

[0081] *1: 3-(2-ethylhexyloxy)-1,2-propanediol, manufactured by Tokyo Chemical Industry Co., Ltd. *2: Benzalkonium chloride, manufactured by Tokyo Chemical Industry Co., Ltd., "Benzalkonium chloride (50% aqueous solution)" *3: Glycerin trioctanoate, "Tricaprylin" manufactured by Fujifilm Wako Pure Chemical Industries, Ltd. *4:1,2-Pentanediol, manufactured by Tokyo Chemical Industry Co., Ltd. *5:1,5-Pentanediol, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd. *6:1,2-Hexanediol, manufactured by Tokyo Chemical Industry Co., Ltd. *7:1,2-Octanediol, manufactured by Tokyo Chemical Industry Co., Ltd. *8:1,2,10-decantriol, manufactured by Tokyo Chemical Industry Co., Ltd. *9:2-Methyl-1,3-propanediol, manufactured by Tokyo Chemical Industry Co., Ltd. *10:2-Methylpentane-2,4-diol, manufactured by Tokyo Chemical Industry Co., Ltd. *11: 2-Ethyl-1,3-Hexanediol, manufactured by Tokyo Chemical Industry Co., Ltd., "2-Ethyl-1,3-Hexanediol (Isomer Mixture)" *12: Glycerol, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd. *13: Propylene glycol, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd. *14: 1,3-Butylene glycol, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd. ("1,3-Butanediol") *15:1,2,6-Hexanetriol, manufactured by Tokyo Chemical Industry Co., Ltd. *16: Tripropylene glycol, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd., "Tripropylene Glycol (Isomer Mixture)" *17: Polyoxyethylene (6) lauryl ether, manufactured by Kao Corporation, "Emulgen 108" *18: Lactic acid, manufactured by Fujifilm Wako Pure Chemical Industries, Ltd., "Lactic Acid (Active: 90%)"

[0082] Tables 2-6 show that when the liquid composition of this embodiment is applied to the skin surface, it exhibits excellent bactericidal effect and its persistence, and that the synergistic effect of using components (A) and (B) in combination is also high. Furthermore, from the comparison between Comparative Example 1 and Comparative Examples 2 and 3 in Table 2, it can be seen that when the target object for application of the liquid composition is skin, the bactericidal effect of the bactericide is less likely to be obtained compared to stainless steel and glass. [Industrial applicability]

[0083] According to the present invention, it is possible to provide a bottled liquid composition that exhibits excellent bactericidal and / or virucidal activity and sustained effects, particularly when applied to the skin surface. This bottled liquid composition is useful as a bottled liquid topical skin preparation composition for bactericidal and / or virucidal purposes.< / ph>

Claims

1. Component (A): logP ｏｗ One or more polyols satisfying a value ≥ -0.3, and Ingredient (B): Cationic disinfectant, It contains, The content of component (A) is 0.05% by mass or more and 30% by mass or less. The content of component (B) is 0.01% by mass or more and 10% by mass or less. A containerized liquid composition comprising a liquid composition containing or not containing glycerin trioctanoate, wherein if glycerin trioctanoate is contained, the content of glycerin trioctanoate is less than 2% by mass, the mass ratio of component (B) to component (A) (B / A) is 0.01 or more and 0.25 or less, and the pH at 25°C is 3.5 or more and 7.0 or less, contained in a container.

2. The containerized liquid composition according to claim 1, wherein component (A) is a chain-like polyol having 4 or more carbon atoms.

3. The containerized liquid composition according to claim 1 or 2, wherein the logP ow value of component (A) satisfies 0.

5.

4. Furthermore, the containerized liquid composition according to claim 1 or 2, wherein the liquid composition contained in the container contains one or more selected from the group consisting of the following components (C) and (D). Ingredient (C): One or more surfactants selected from the group consisting of nonionic surfactants and anionic surfactants. Ingredient (D): Organic acid or its salt

5. The containerized liquid composition according to claim 1 or 2, wherein the (number of OH groups / number of C atoms) of component (A) is less than 1.

6. The containerized liquid composition according to claim 1 or 2, wherein the liquid composition contained in the container is a leave-on skin topical preparation composition.

7. logP ｏｗ Use of polyol (A) satisfying a value ≥ -0.3, with or without the use of glycerin trioctanoate, and in the case of the use of glycerin trioctanoate, the content of glycerin trioctanoate in the liquid composition used is less than 2% by mass, the mass ratio of component (B) to component (A) (B / A) is 0.01 or more and 0.25 or less, and the pH of the liquid composition at 25°C is 3.5 or more and 7.0 or less.

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