Blood purification device and method for controlling the blood purification device

Abstract

To provide a blood purification device capable of setting a flow rate by a pump based on a target integrated flow rate by the pump and a target treatment time.SOLUTION: A blood purification device includes a pump, and reception means for receiving input of a target integrated flow rate by the pump and of a target treatment time. The blood purification device calculates a flow rate by the pump based on the target integrated flow rate and on the target treatment time. The blood purification device operates the pump based on the calculated flow rate.SELECTED DRAWING: Figure 8

Description

Technical Field

[0001] The present disclosure relates to a blood purification device and a control method for a blood purification device.

Background Art

[0002] Conventionally, a blood purification device that purifies blood by at least one of dialysis and filtration has been known. For example, Japanese Patent Application Laid-Open No. 2019-37674 (Patent Document 1) discloses a hemodialysis device that purifies blood by dialysis. In the hemodialysis device, set values related to setting items for dialysis treatment are set.

[0003] The hemodialysis device includes a priority setting item selection means for selecting one of the setting items of treatment time, target ultrafiltration volume, and ultrafiltration rate, and a set value update means for updating the set values of other related setting items based on the set value of the changed setting item. When one set value (treatment time) is selected by the priority setting item selection means and one of the other two set values (ultrafiltration rate) is changed in the hemodialysis device, the set value update means maintains the set value (treatment time) selected by the priority setting item selection means and updates the other set value (target ultrafiltration volume) based on the changed one set value (ultrafiltration rate).

Prior Art Documents

Patent Documents

[0004]

Patent Document 1

Summary of the Invention

Problems to be Solved by the Invention

[0005] In a blood purification device, if the flow rate by a pump can be set based on the target integrated flow rate by the pump and the target treatment time, the usability of the blood purification device will be improved.

[0006] This disclosure has been made in view of the above-mentioned problems, and its purpose is to provide a blood purification device and a method for controlling the blood purification device that can set the flow rate of a pump based on a target cumulative flow rate and a target treatment time. [Means for solving the problem]

[0007] According to a certain aspect of this disclosure, the blood purification device further comprises a pump, a receiving means for receiving input of a target cumulative flow rate by the pump and a target treatment time, a calculation means for calculating the flow rate by the pump based on the target cumulative flow rate and the target treatment time, and a pump control means for operating the pump based on the calculated flow rate.

[0008] In accordance with other aspects of this disclosure, a method for controlling a blood purification device comprises the steps of receiving inputs for a target cumulative flow rate by a pump and a target treatment time, calculating a flow rate by the pump based on the target cumulative flow rate and the target treatment time, and operating the pump based on the calculated flow rate. [Effects of the Invention]

[0009] According to this disclosure, the flow rate of the pump can be set based on the target cumulative flow rate and the target treatment time. [Brief explanation of the drawing]

[0010] [Figure 1] This diagram shows a schematic overview of the overall configuration of a blood purification device. [Figure 2] This diagram illustrates the input settings for a blood purification device. [Figure 3] This is a diagram illustrating the first example of operation. [Figure 4] This is a diagram illustrating the second example of operation. [Figure 5] This is a diagram illustrating the third example of operation. [Figure 6] This is a diagram illustrating the fourth example of operation. [Figure 7]It is a functional block diagram for explaining the functional configuration of a blood purification device. [Figure 8] It is a flowchart for explaining the flow of processing executed in a blood purification device.

Embodiments for Carrying Out the Invention

[0011] Hereinafter, embodiments of the present disclosure will be described with reference to the drawings. In the following description, the same members are denoted by the same reference numerals. Their names and functions are also the same. Therefore, detailed descriptions thereof will not be repeated.

[0012] Specifically, hereinafter, continuous renal replacement therapy (CRRT) will be described as an example. CRRT is mainly applied to critically ill patients such as those with acute renal failure in which renal function has rapidly declined. Hereinafter, the "user" typically refers to medical staff such as doctors and nurses.

[0013] <A. Overall Configuration> FIG. 1 is a diagram showing an outline of the overall configuration of a blood purification device 1. As shown in FIG. 1, the blood purification device 1 includes, in this example, a replacement fluid pump 31, a dialysis fluid pump 32, a drainage pump 33, a blood pump 34, a hemofilter 50, a syringe 60, a control device and a touch screen (see FIG. 7) to be described later.

[0014] The hemofilter 50 removes unnecessary or toxic substances from the blood. The hemofilter 50 has a hollow fiber membrane. The hemofilter 50 allows blood to flow inside the hollow fiber membrane. As an example, by applying pressure from the inside to the outside of the hollow fiber membrane, medium-sized substances such as water, waste products in the blood, and cytokines move from the inner region to the outer region of the hollow fiber membrane within the hemofilter 50. Thereby, the blood is purified.

[0015] The replacement fluid pump 31 supplies a replacement fluid 41, also referred to as a replenishing fluid or a substitution fluid, to the blood circuit (flow path). The dialysate pump 32 supplies a dialysate 42 to the blood circuit. Specifically, the dialysate pump 32 supplies the dialysate to the outer region of the hollow fiber membrane of the hemofiltration filter 50. The drainage pump 33 sends the drainage (the drainage of the dialysate) containing the substances (substances in the blood) that have moved to the outer region of the hollow fiber membrane in the hemofiltration filter 50 to the drainage container 43. The drainage pump 33 is also referred to as a "filtration pump".

[0016] The operations of the replacement fluid pump 31, the dialysate pump 32, and the drainage pump 33 are controlled by a control device.

[0017] The syringe 60 supplies an anticoagulant to the blood circuit based on the operation of the user in order to prevent the blood from coagulating in the blood circuit and the hemofiltration filter 50.

[0018] In FIG. 1, the device configuration of the post-dilution method is taken as an example for explanation, but it is not limited thereto, and the processing of the present disclosure is also applicable to the device of the pre-dilution method.

[0019] <B. Setting Input Items> FIG. 2 is a diagram for explaining the setting input items for the blood purification device 1. As shown in FIG. 2, the setting input items differ depending on the CRRT mode (treatment mode, setting mode).

[0020] The setting input items include the target integrated amount (L) of the replacement fluid, the target ultrafiltration amount (L), the target integrated amount (L) of the dialysate, and the target treatment time. The CRRT modes include continuous hemofiltration (CHF), continuous hemodialysis (CHD), continuous hemodiafiltration (CHDF), and slow continuous ultrafiltration (SCUF). In the blood purification device 1 of this example, it is possible to perform all of the above four modes.

[0021] For continuous hemofiltration (CHF), input of the target cumulative volume of replacement fluid and the target treatment time is required (mandatory). For continuous hemodialysis (CHD), input of the target cumulative volume of dialysate and the target treatment time is required. For continuous hemodiafiltration (CHDF), input of the target cumulative volume of replacement fluid, the target cumulative volume of dialysate, and the target treatment time is required. For continuous slow ultrafiltration (SCUF), input of the target amount of fluid removed and the target treatment time is required.

[0022] As described above, inputting the target treatment time is mandatory for all four modes of CRRT. However, inputting the target amount of fluid to be removed is optional for continuous hemofiltration (CHF), continuous hemodialysis (CHD), and continuous hemodialysis (CHD). Inputting the target amount of fluid to be removed is required when fluid is removed in these three modes.

[0023] In this example, the upper limit of the target cumulative volume of replacement fluid is 999.9L. The upper limit of the target cumulative volume of dialysate is 999.9L. The upper limit of the target fluid removal volume is 999.99L. The upper limit of the target treatment time is 99 hours and 59 minutes. Furthermore, blood purification device 1 is required to satisfy the following four conditions (1) to (4).

[0024] (1) The flow rate (discharge volume) per hour from the replenishment fluid pump 31 is 0 mL / h or more and 8000 mL / h or less.

[0025] (2) The flow rate (discharge volume) per hour from the dialysate pump 32 is 0 mL / h or more and 8000 mL / h or less.

[0026] (3) The amount of water removed per hour (i.e., the water removal rate) is 0 mL / h or more and 8000 mL / h or less.

[0027] (4) The flow rate (discharge volume) per hour from the drainage pump 33 is greater than 0 mL / h and 8000 mL / h or less. Specifically, the sum of the flow rate per hour from the replacement fluid pump 31, the flow rate per hour from the dialysate pump 32, and the ultrafiltration rate is greater than 0 mL / h and 8000 mL / h or less.

[0028] The upper limit of "8000 mL / h" in the above conditions (1) to (4) is based solely on the pump capacity of each pump 31 to 33 installed in the blood purification device 1, and is merely an example. This value will vary depending on the type of pump installed in the blood purification device 1.

[0029] The blood purification device 1 automatically selects one of the four CRRT modes (treatment modes) based on the input settings. If only the target cumulative volume of replacement fluid is entered, the blood purification device 1 automatically selects continuous hemofiltration (CHF) as the CRRT mode. If only the target cumulative volume of dialysate is entered, the blood purification device 1 automatically selects continuous hemodialysis (CHD) as the CRRT mode.

[0030] If both the target cumulative volume of replacement fluid and the target cumulative volume of dialysate are entered, the blood purification device 1 automatically selects continuous hemodiafiltration (CHDF) as the CRRT mode. If neither the target cumulative volume of replacement fluid nor the target cumulative volume of dialysate is entered, but the target amount of fluid to be removed is entered, the blood purification device 1 automatically selects continuous slow ultrafiltration (SCUF) as the CRRT mode.

[0031] The following provides further details about the CRRT modes described above. In continuous hemodiafiltration (CHDF), as shown in Figure 1, four pumps 31-34, replacement fluid 41, and dialysate 42 are used. In addition, in the blood purification device 1, one drug solution may be used as both replacement fluid 41 and dialysate 42.

[0032] In contrast, in continuous hemofiltration (CHF), of the four pumps 31-34, the replacement fluid pump 31, the drainage pump 33, and the blood pump 34 are used. That is, the dialysate pump 32 is not used. Therefore, in continuous hemofiltration (CHF), of the replacement fluid 41 and dialysate 42, only the replacement fluid 41 is used.

[0033] Similarly, in continuous hemodialysis (CHD), only the dialysate pump 32, drainage pump 33, and blood pump 34 are used out of the four pumps 31-34. That is, the replacement fluid pump 31 is not used. Therefore, in continuous hemodialysis (CHD), only the dialysate 42 is used out of the replacement fluid 41 and dialysate 42.

[0034] In sustained continuous slow ultrafiltration (SCUF), only the drainage pump 33 and the blood pump 34 are used out of the four pumps 31-34. That is, the replacement fluid pump 31 and the dialysate pump 32 are not used. Therefore, in sustained continuous slow ultrafiltration (SCUF), the replacement fluid 41 and the dialysate 42 are not used.

[0035] <C.ユーザインターフェイス> This section describes the user interface displayed on the touchscreen of blood purification device 1. Four operation examples are provided below.

[0036] (c1. First example of operation) Figure 3 is a diagram illustrating the first example of operation. As shown in Figure 3, the blood purification device 1 (more specifically, the control device) displays object image 111 (four "+" object images) on the touchscreen 10, which increases the numerical value of each digit of the target cumulative volume of the replacement fluid by 1, and object image 112 (four "-" object images) on the touchscreen 10, which decreases the numerical value of each digit of the target cumulative volume of the replacement fluid by 1. The numerical value entered using object images 111 and 112 is displayed in the display area 113. In this example, "100.0" is entered, and "100.0L" is displayed in the display area 113. The blood purification device 1 also displays the flow rate of the replacement fluid (pump flow rate), calculated by the calculation described later, in the display area 114 on the touchscreen 10.

[0037] The blood purification device 1 further displays object images 121 (four "+" object images) on the touchscreen 10, which increase each digit of the target cumulative volume of dialysate by 1, and object images 122 (four "-" object images) which decrease each digit of the target cumulative volume of dialysate by 1. The numerical value entered using object images 121 and 122 is displayed in the display area 123. In this example, "100.0" is entered, and "100.0L" is displayed in the display area 123. The blood purification device 1 also displays the dialysate flow rate (pump flow rate), calculated by a calculation described later, in the display area 124 on the touchscreen 10.

[0038] The blood purification device 1 further displays object images 131 (four "+" object images) on the touchscreen 10, which increase each digit of the target fluid removal volume by 1, and object images 132 (four "-" object images) which decrease each digit of the target fluid removal volume by 1. The numerical value entered using object images 131 and 132 is displayed in the display area 133. In this example, "10.00" is entered, and "10.00L" is displayed in the display area 133. The blood purification device 1 also displays the fluid removal rate, calculated by a calculation described later, in the display area 134 on the touchscreen 10.

[0039] The blood purification device 1 further displays object images 141 (four "+" object images) on the touchscreen 10, which increment each digit (hours digit and minute digit) of the target treatment time by 1, and object images 142 (four "-" object images) which decrement each digit of the target treatment time by 1. The numerical value entered using object images 141 and 142 is displayed in the display area 143. In this example, "30.00" is entered, and "30 hours 00 minutes" is displayed in the display area 143. The blood purification device 1 also displays the drainage flow rate (pump flow rate), calculated by a calculation described later, in the display area 144 on the touchscreen 10.

[0040] The blood purification device 1 displays a cancel button 150 on the touchscreen 10 for canceling settings (specifically, entered values ​​and calculated values) and a confirm button 160 for registering each of the calculated values ​​as settings.

[0041] Note that the object images 111, 112, 131, 132, 121, 122, 141, and 142, as well as the cancel button 150 and the confirm button 160, are software keys in this example.

[0042] When the target cumulative volume of replacement fluid, the target cumulative volume of dialysate, the target amount of fluid removed, and the target treatment time are entered based on user input, the blood purification device 1 calculates the flow rate of replacement fluid (pump flow rate), the flow rate of dialysate (pump flow rate), the fluid removal rate, and the flow rate of drainage fluid (pump flow rate). In this case, continuous hemodiafiltration (CHDF) is automatically selected from among the four CRRT modes.

[0043] Specifically, the blood purification device 1 calculates the flow rate (pump flow rate) of the replacement fluid by dividing the target cumulative volume of replacement fluid "100.0 L" by the target treatment time "30 hours 00 minutes". The blood purification device 1 displays the calculated result "3333 mL / h" in the display area 114.

[0044] Furthermore, the blood purification device 1 calculates the flow rate (pump flow rate) of the dialysate by dividing the target cumulative volume of dialysate, "100.0 L," by the target treatment time, "30 hours 00 minutes." The blood purification device 1 displays the calculated result, "3333 mL / h," in the display area 124.

[0045] Furthermore, the blood purification device 1 calculates the fluid removal rate by dividing the target fluid removal volume "10.00 L" by the target treatment time "30 hours 00 minutes". The blood purification device 1 displays the calculated result "333 mL / h" in the display area 134.

[0046] When the blood purification device 1 calculates the flow rate of the replacement fluid, the flow rate of the dialysate, and the ultrafiltration rate, it calculates the sum of these three values ​​and displays the calculated sum in the display area 144. In this example, the blood purification device 1 displays 6999 mL / h (= 3333 + 333 + 3333) in the display area 144.

[0047] Incidentally, the replacement fluid flow rate of "3333 mL / h" satisfies the first condition mentioned above, "greater than or equal to 0 mL / h and 8000 mL / h or less." The dialysate flow rate of "3333 mL" satisfies the second condition mentioned above, "greater than or equal to 0 mL / h and 8000 mL / h or less." The ultrafiltration rate of "333 mL / h" satisfies the third condition mentioned above, "greater than or equal to 0 mL / h and 8000 mL / h or less." Furthermore, the drainage flow rate of "6999 mL / h," which is the sum of the replacement fluid flow rate, the ultrafiltration rate, and the dialysate flow rate, satisfies the fourth condition mentioned above, "greater than 0 mL / h and 8000 mL / h or less."

[0048] The blood purification device 1 will be in a state where the select button 160 can be selected if all four of the above conditions are met. Therefore, in this example, the blood purification device 1 will be in an active state with the select button 160 active. In other words, the blood purification device 1 will be in a state where it can accept setting registration operations.

[0049] When the user selects the confirmation button 160, the blood purification device 1 sets and registers the flow rate of the replacement fluid, the flow rate of the dialysate, the ultrafiltration rate, and the drainage flow rate. Based on these settings, the blood purification device 1 operates the respective pumps 31-33.

[0050] (c2. Second example of operation) Figure 4 illustrates the second operating example. As shown in Figure 4, the target cumulative volume of replacement fluid and the target treatment time are entered into the blood purification device 1. In this case, continuous hemofiltration (CHF) is automatically selected from the four CRRT modes. In this example, since the target amount of fluid to be removed is not entered, the fluid removal rate remains at 0 mL / h.

[0051] The blood purification device 1 calculates the flow rate (pump flow rate) of the replacement fluid by dividing the target cumulative volume of replacement fluid "100.0 L" by the target treatment time "30 hours 00 minutes". The blood purification device 1 displays the calculated result "3333 mL / h" in the display area 114.

[0052] Since the blood purification device 1 has a water removal rate of 0 mL / h, it displays the flow rate of the replacement fluid in the display area 144. In this example, the blood purification device 1 displays 3333 mL / h in the display area 144.

[0053] Incidentally, the flow rate of the replenishment solution, "3333 mL / h," satisfies the first condition mentioned above, "greater than or equal to 0 mL / h and 8000 mL / h or less." The water removal rate, "0 mL / h," satisfies the third condition mentioned above, "greater than or equal to 0 mL / h and 8000 mL / h or less." Furthermore, the drainage flow rate, "3333 mL / h," which is the sum of the replenishment solution flow rate and the water removal rate, satisfies the fourth condition mentioned above, "greater than 0 mL / h and 8000 mL / h or less."

[0054] The blood purification device 1 will be in a state where the select button 160 can be selected if all three of the above conditions are met. Therefore, in this example, the blood purification device 1 will be in an active state with the select button 160 active. In other words, the blood purification device 1 will be in a state where it can accept setting registration operations.

[0055] When the user selects the confirmation button 160, the blood purification device 1 sets and registers the flow rate of the replacement fluid, the water removal rate, and the flow rate of the drained fluid. Based on the calculated flow rate of the replacement fluid and the drained fluid, the blood purification device 1 operates the respective pumps 31 and 33.

[0056] (c3. Third example of operation) Figure 5 illustrates the third operating example. As shown in Figure 5, all values—the target cumulative volume of replacement fluid, the target cumulative volume of dialysate, the target amount of fluid removed, and the target treatment time—have been entered. Therefore, continuous hemodiafiltration (CHDF) is automatically selected from the four CRRT modes.

[0057] However, the flow rate of the replacement fluid (pump flow rate), which is calculated by dividing the target cumulative volume of replacement fluid "100.0 L" by the target treatment time "2 hours 00 minutes", is "50,000 mL / h". Similarly, the flow rate of the dialysate (pump flow rate), which is calculated by dividing the target cumulative volume of dialysate "100.0 L" by the target treatment time "2 hours 00 minutes", is "50,000 mL / h".

[0058] Thus, the flow rates of the replacement fluid and the dialysate exceed their respective upper limits of "8000 mL / h". Furthermore, the flow rates of the replacement fluid and the dialysate exceed the upper limit of "9999 mL / h", which is the range that can be displayed in display areas 114 and 124. For this reason, the blood purification device 1 displays "9999 mL / h" in display areas 114 and 124, and displays this value in a different manner than usual. As an example, the blood purification device 1 displays the value in display areas 114 and 124 in red.

[0059] Furthermore, if the flow rate of the replacement fluid and the flow rate of the dialysate in the blood purification device 1 exceeds the upper limit of 8000 mL / h, even if it is 9999 mL / h or less, the values ​​displayed in the display areas 114 and 124 will be displayed in a different format than usual (red display).

[0060] On the other hand, the fluid removal rate, which is the value obtained by dividing the target fluid removal amount "10.00 L" by the target treatment time "2 hours 00 minutes", is "5000 mL / h". Therefore, the fluid removal rate is less than or equal to the upper limit of "8000 mL / h". Thus, the fluid removal rate satisfies the third condition mentioned above (0 mL / h or more and 8000 mL / h or less). For this reason, the fluid removal rate in the display area 134 will be displayed in the normal manner.

[0061] As mentioned above, the drainage flow rate (pump flow rate) is the sum of the replacement fluid flow rate, the dialysate flow rate, and the ultrafiltration rate. Therefore, in this example, the drainage flow rate is 105,000 mL / h (= 50,000 + 50,000 + 5,000).

[0062] Thus, the drainage flow rate exceeds the upper limit of "8000 mL / h". Furthermore, the drainage flow rate exceeds the upper limit of the displayable range in the display area 144, which is "9999 mL / h". For this reason, the blood purification device 1 displays "9999 mL / h" in the display area 144 and displays this value in a different manner than usual. As an example, the blood purification device 1 displays the value in the display area 144 in red.

[0063] Furthermore, even if the drainage flow rate of the blood purification device 1 is 9999 mL / h or less, if it exceeds the upper limit of the drainage flow rate of 8000 mL / h, the value displayed in the display area 144 will be displayed in a different format than usual (red display).

[0064] When at least one of the values of the replenishing fluid flow rate, the dialysate flow rate, the ultrafiltration rate, and the drainage flow rate of the blood purification device 1 does not satisfy the set conditions for each, the determination button 160 is not set to an active state. In the case of this example, since the three values (the replenishing fluid flow rate, the dialysate flow rate, the drainage flow rate) do not satisfy the set conditions for each, the blood purification device 1 does not set the determination button 160 to an active state as shown in the figure. Therefore, in this example, unlike FIG. 3, the blood purification device 1 does not accept a setting registration operation.

[0065] (c4. Fourth operation example) FIG. 6 is a diagram for explaining a fourth operation example. As shown in FIG. 6, the target treatment time is not input. In this case, even if the target integrated amount of the replenishing fluid, the target integrated value of the dialysate, and the target ultrafiltration amount are input, the blood purification device 1 cannot calculate the replenishing fluid flow rate, the dialysate flow rate, the ultrafiltration rate, and the drainage flow rate which is the sum of these three numerical values.

[0066] Therefore, the blood purification device 1 displays the symbol "----" indicating that calculation is impossible in the display areas 114, 124, 134, and 144. Also, the blood purification device 1 does not set the determination button 160 to an active state as shown in the figure. Therefore, in this example, unlike FIG. 3, the blood purification device 1 does not accept a setting registration operation.

[0067] <D. Functional block> FIG. 7 is a functional block diagram for explaining the functional configuration of the blood purification device 1. As shown in FIG. 7, the blood purification device 1 includes a touch screen 10, a control device 20, and a pump group 30.

[0068] The touch screen 10 includes a touch panel 11 and a display 12. The touch panel 11 is installed so as to overlap the display 12. The pump group 30 includes a replenishing fluid pump 31, a dialysate pump 32, a drainage pump 33, and a blood pump 34.

[0069] The control device 20 includes an input receiving unit 21, a calculation unit 22, a determination unit 23, a display control unit 24, and a pump control unit 25. The control device 20 also includes a processor and memory (not shown).

[0070] The following explanation will focus on the processing of each part of the control device 20. For the sake of explanation, we will use the case of continuous hemodiafiltration (CHDF) using four pumps 31-34 as an example.

[0071] The input receiving unit 21 receives input of the target cumulative flow rate of the replacement fluid, the target cumulative volume of the dialysate, the target amount of fluid to be removed, and the target treatment time based on user input to the touch panel 11 (process (i)). These numerical values ​​are entered using object images 111, 112, 121, 122, 131, 132, 141, and 142, as described above (see Figure 3, etc.). The input receiving unit 21 sends the entered data (input data) to the calculation unit 22 (process (ii)).

[0072] The input reception unit 21 further sends the input data to the display control unit 24. In this case, when the input reception unit 21 receives data input via the touch panel 11, the display control unit 24 reflects the input on the display 12 (process (v)). For example, when the object image 111 in Figure 3 is selected, the numerical value of the target cumulative amount of replenishment liquid displayed in the display area 113 is updated.

[0073] The calculation unit 22 calculates the flow rate of the replacement fluid based on the target cumulative flow rate of the replacement fluid and the target treatment time (see display area 114 in Figure 3). The calculation unit 22 calculates the flow rate of the dialysate based on the target cumulative volume of the dialysate and the target treatment time (see display area 124 in Figure 3). The calculation unit 22 calculates the ultrafiltration rate based on the target ultrafiltration amount and the target treatment time (see display area 134 in Figure 3). The calculation unit 22 calculates the flow rate of the drained fluid by summing the calculated flow rate of the replacement fluid, the flow rate of the dialysate, and the ultrafiltration rate (see display area 144 in Figure 3).

[0074] The calculation unit 22 sends the four calculated values ​​to the determination unit 23. Specifically, the calculation unit 22 sends the flow rate of the replenishment fluid (pump flow rate of the replenishment fluid), the flow rate of the dialysate (pump flow rate of the dialysate), the ultrafiltration rate, and the flow rate of the drained fluid (pump flow rate of the drained fluid) to the determination unit 23 (process (iii)).

[0075] The determination unit 23 determines whether the flow rate of the replacement fluid, the flow rate of the dialysate, the ultrafiltration rate, and the flow rate of the drained fluid are within predetermined ranges.

[0076] In this example, the determination unit 23 determines whether the flow rate of the replenishment solution is 0 mL / h or more and 8000 mL / h or less. In this example, the range of 0 mL / h or more and 8000 mL / h or less corresponds to the "first range" of this disclosure.

[0077] The determination unit 23 determines whether the flow rate of the dialysate is 0 mL / h or more and 8000 mL / h or less. In this example, the range of 0 mL / h or more and 8000 mL / h or less corresponds to the "second range" of this disclosure.

[0078] The determination unit 23 determines whether the water removal rate is 0 mL / h or more and 8000 mL / h or less. In this example, the range of 0 mL / h or more and 8000 mL / h or less corresponds to the "third range" of this disclosure.

[0079] The determination unit 23 determines whether the flow rate of the drained liquid is greater than 0 mL / h and 8000 mL / h or less. In this example, the range greater than 0 mL / h and 8000 mL / h or less corresponds to the "fourth range" of this disclosure.

[0080] The determination unit 23 sends the four determination results to the display control unit 24. If all four determination results are "OK" (all four values ​​are within the range), the display control unit 24 activates the display state of the OK button 160 on the display 12, for example as shown in Figure 3 (process (v)). If at least one of the four determination results is "NG" (at least one value is outside the range), the display control unit 24 keeps the display state of the OK button 160 inactive, for example as shown in Figure 5.

[0081] When the display state of the OK button 160 is active, the user selects the OK button 160 via the touch panel 11, and a setting registration instruction is sent from the touch screen 10 to the input reception unit 21 of the control device 20 (process (vi)).

[0082] The input receiving unit 21 sends a setting registration instruction to the calculation unit 22. Upon receiving the setting registration instruction, the calculation unit 22 sends the results of the above calculation to the pump control unit 25. Specifically, the calculation unit 22 sends four numerical values ​​(flow rate of replenishment fluid, flow rate of dialysate, ultrafiltration rate, and flow rate of drained fluid) calculated based on the input data of process (ii) to the pump control unit 25.

[0083] The pump control unit 25 controls the pump group 30 based on four numerical values ​​obtained from the calculation unit 22. Specifically, the pump control unit 25 operates the replenishment fluid pump 31 based on the calculated replenishment fluid flow rate. The pump control unit 25 operates the dialysate pump 32 based on the calculated dialysate flow rate. The pump control unit 25 operates the drainage pump 33 based on the calculated drainage fluid flow rate.

[0084] More specifically, the pump control unit 25 operates each of the pumps 31, 32, 33, and 34 based on receiving an operation from a medical professional (such as pressing a button not shown in the diagram). The pump control unit 25 also operates the blood pump 34 at a pre-instructed pump flow rate, regardless of the calculation result from the calculation unit 22.

[0085] (summary) The configuration and processing of blood purification device 1 can be summarized as follows:

[0086] (1) The blood purification device 1 further comprises pumps (31, 32), an input receiving unit 21 that receives input of a target cumulative flow rate by the pumps (in this embodiment, a target cumulative flow rate of replacement fluid and a target cumulative flow rate of dialysate), and a target treatment time, a calculation unit 22 that calculates the flow rate by the pumps based on the target cumulative flow rate and the target treatment time, and a pump control unit 25 that operates the pumps based on the calculated flow rate.

[0087] With this configuration, the flow rate of the pump can be set based on the target cumulative flow rate and the target treatment time. Therefore, the blood purification device 1 can improve usability.

[0088] (2) The input receiving unit 21 accepts a flow rate setting registration operation, provided that the calculated flow rate is within a predetermined range (in this embodiment, the first range and the second range) (processing (vi) in Figure 7). When the flow rate is set and registered by the setting registration operation, the pump control unit 25 operates the pump based on the set and registered flow rate.

[0089] With this configuration, the blood purification device 1 will not accept a flow rate setting registration operation if the flow rate from the pump is outside a predetermined range. Therefore, the blood purification device 1 can prompt the user to set the target cumulative flow rate from the pump and the target treatment time so that the flow rate from the pump falls within a predetermined range.

[0090] (3) Focusing on the replenishment fluid, the following applies: The pump includes a replenishment fluid pump 31. The target cumulative flow rate includes the target cumulative flow rate of the replenishment fluid. The calculation unit 22 calculates the flow rate of the replenishment fluid as the flow rate from the pump based on the target cumulative flow rate of the replenishment fluid and the target treatment time. The input reception unit 21 accepts the setting registration operation for the flow rate of the replenishment fluid, provided that the flow rate of the replenishment fluid is within the first range described above. When the flow rate of the replenishment fluid is set and registered by the setting registration operation, the pump control unit 25 operates the replenishment fluid pump 31 based on the set and registered flow rate of the replenishment fluid.

[0091] With this configuration, the blood purification device 1 will not accept a setting registration operation for the replacement fluid flow rate if the flow rate of the replacement fluid from the replacement fluid pump 31 is not within the first range. Therefore, the blood purification device 1 can prompt the user to set the target cumulative flow rate of the replacement fluid from the replacement fluid pump 31 and the target treatment time so that the flow rate from the replacement fluid pump 31 falls within the first range.

[0092] (4) Focusing on the dialysate, the following applies: The pump includes the dialysate pump 32. The target cumulative flow rate includes the target cumulative flow rate of the dialysate. Calculation unit 22 teeth Based on the target cumulative flow rate of the dialysate and the target treatment time, the flow rate of the dialysate is calculated as the flow rate by the pump. The input reception unit 21 accepts the setting registration operation for the dialysate flow rate, provided that the dialysate flow rate is within the second range described above. When the dialysate flow rate is set and registered by the setting registration operation, the pump control unit 25 operates the dialysate pump 32 based on the set and registered dialysate flow rate.

[0093] With this configuration, the blood purification device 1 will not accept a setting registration operation for the dialysate flow rate if the dialysate flow rate from the dialysate pump 32 is not within the second range. Therefore, the blood purification device 1 can prompt the user to set the target cumulative flow rate of dialysate from the dialysate pump 32 and the target treatment time so that the flow rate from the dialysate pump 32 falls within the second range.

[0094] (5) Focusing on water removal, the process is as follows: Specifically, the input receiving unit 21 further receives input of the target amount of water to be removed. The calculation unit 22 further calculates the water removal rate based on the target amount of water to be removed and the target treatment time. The input receiving unit 21 accepts the setting registration operation for the water removal rate, provided that the water removal rate is within the third range described above.

[0095] With this configuration, the blood purification device 1 will not accept a setting registration operation for the ultrafiltration rate if the ultrafiltration rate is not within the third range. Therefore, the blood purification device 1 can prompt the user to set the target ultrafiltration amount and target treatment time so that the ultrafiltration rate falls within the third range.

[0096] (6) Focusing on the drainage, the following applies. The pump includes a drainage pump 33. The calculation unit 22 further calculates the drainage flow rate based on the calculated flow rates (in this example, the flow rate of the replacement fluid and the flow rate of the dialysate) and the water removal rate. The input reception unit 21 accepts a setting registration operation for the drainage flow rate, provided that the drainage flow rate is within the fourth range described above. When the drainage flow rate is set and registered by the setting registration operation, the pump control unit 25 operates the drainage pump 33 based on the set and registered drainage flow rate.

[0097] With this configuration, the blood purification device 1 will not accept a setting registration operation for the drainage flow rate if the drainage flow rate from the drainage pump 33 is not within the fourth range. Therefore, the blood purification device 1 can prompt the user to set the target cumulative flow rate from the drainage pump 33 and the target treatment time so that the flow rate from the drainage pump 33 falls within the fourth range.

[0098] (7) The blood purification device 1 further comprises a touchscreen 10 and a display control unit 24 that displays a confirmation button 160 (object image) on the touchscreen 10. The setting registration operation described above is a touch operation on the confirmation button 160. With this configuration, medical personnel can register the flow rate setting by touching the confirmation button 160.

[0099] <E. Control Structure> Hereinafter, the case where a medical worker selects continuous hemodiafiltration (CHDF) as a treatment policy will be described as an example. Also, it is assumed that the medical worker selects to perform ultrafiltration. That is, the case where a medical worker inputs values to the above-described four setting input items will be described as an example.

[0100] FIG. 8 is a flowchart for explaining the flow of processing executed in the blood purification device 1. As shown in FIG. 8, in step S1, the control device 20 (specifically, the processor) of the blood purification device 1 sets the determination button 160 to a non-selectable state (that is, a non-active state). In step S2, the control device 20 determines whether or not it has received an input of the target integrated amount of the replacement fluid, the target integrated amount of the dialysate, the target ultrafiltration amount, and the target treatment time.

[0101] When it is determined that the input of the four values has been received (YES in step S2), in step S3, the control device 20 calculates the flow rate of the replacement fluid (pump flow rate), the flow rate of the dialysate (pump flow rate), the ultrafiltration rate, and the flow rate of the drainage liquid (pump flow rate) based on the target treatment time. When it is determined that the input of the four values has not been received (NO in step S2), the control device 20 returns the process to step S2.

[0102] In step S4, the control device 20 determines whether or not the flow rate of the replacement fluid calculated in step S3 is within the above-described first range (in this example, 0 mL / h or more and 8000 mL / h or less). When it is determined that the flow rate is within the first range (YES in step S4), in step S5, the control device 20 determines whether or not the flow rate of the dialysate calculated in step S3 is within the above-described second range (in this example, 0 mL / h or more and 8000 mL / h or less). When it is determined that the flow rate is outside the first range (NO in step S4), the control device 20 advances the process to step S12.

[0103] If the flow rate of the dialysate calculated in step S3 is determined to be within the second range (YES in step S5), the control device 20 determines in step S6 whether the ultrafiltration rate calculated in step S3 is within the third range described above (in this example, 0 mL / h or more and 8000 mL / h or less). If the ultrafiltration rate is determined to be outside the third range (NO in step S6), the control device 20 proceeds to step S12.

[0104] If the water removal rate calculated in step S3 is determined to be within the third range (YES in step S6), the control device 20 determines in step S7 whether the flow rate of the drained liquid calculated in step S3 is within the fourth range described above (in this example, greater than 0 mL / h and 8000 mL / h or less). If the flow rate is determined to be outside the fourth range (NO in step S7), the control device 20 proceeds to step S12. The order of each process in steps S4 to S7 is not particularly limited.

[0105] After step S7, in step S8, the control device 20 sets the OK button 160 to a selectable state (i.e., an active state). The control device 20 changes the state of the OK button 160. In step S9, the control device 20 determines whether the cancel button 150 has been selected.

[0106] If the cancel button 150 is selected (YES in step S9), the control device 20 returns to step S2. If the cancel button 150 is not selected (NO in step S9), in step S10, the control device 20 determines whether or not the confirm button 160 has been selected.

[0107] If it is determined that the confirmation button 160 has been selected (YES in step S10), in step S11, the control device 20 sets and registers the calculation result calculated in step S3. In this example, the control device 20 stores the flow rate of the replacement fluid, the flow rate of the dialysate, the ultrafiltration rate, and the flow rate of the drained fluid in a predetermined area of ​​the memory.

[0108] Furthermore, based on the calculation results, the control device 20 operates the replacement fluid pump 31, the dialysate pump 32, and the drainage pump 33 upon receiving further user input (dialysis initiation operation).

[0109] If it is determined that the OK button 160 is not selected (NO in step S10), the control device 20 returns to step S9.

[0110] In step S12, the control device 20 determines whether the cancel button 150 has been selected. If it is determined that the cancel button 150 has been selected (YES in step S12), the control device 20 returns to step S2. If the cancel button 150 has not been selected, in step S13, the control device 20 determines whether it has received a user operation to change at least one of the following: the target cumulative volume of replacement fluid, the target cumulative volume of dialysate, the target amount of fluid removed, and the target treatment time.

[0111] If it is determined that user input has been received (YES in step S13), the control device 20 returns to step S3. If it is determined that user input has not been received (NO in step S13), the control device 20 returns to step S12.

[0112] In the above explanation, continuous hemodiafiltration (CHDF) was used as an example among the four modes of CRRT, but the above treatment can also be applied to the other three modes. Furthermore, it is not limited to CRRT, but can also be applied to non-continuous methods such as hemodialysis (HD), extracorporeal ultrafiltration (ECUM), hemofiltration (HF), and hemodiafiltration (HDF).

[0113] The embodiments disclosed herein should be considered in all respects to be illustrative and not restrictive. The scope of this disclosure is indicated by the claims and all modifications within the meaning and scope of the claims are intended to be included. [Explanation of symbols]

[0114] 1 Blood purification device, 10 Touchscreen, 11 Touch panel, 12 Display, 20 Control device, 21 Input reception unit, 22 Calculation unit, 23 Judgment unit, 24 Display control unit, 25 Pump control unit, 31 Replacement fluid pump, 32 Dialysis fluid pump, 33 Drainage pump, 34 Blood pump, 41 Replacement fluid, 42 Dialysis fluid, 43 Drainage container, 50 Blood filter, 60 Syringe, 111, 112, 121, 122, 131, 132, 141, 142 Object images, 113, 114, 123, 124, 133, 134, 143, 144 Display area, 160 Confirm button.

Claims

1. A blood circuit, Dialysis fluid pump and Equipped with a drainage pump, The blood circuit includes a blood filter having a hollow fiber membrane and a blood pump that sends blood to the blood filter. The dialysate pump supplies dialysate to the outer region of the hollow fiber membrane within the hemofilter. The drainage pump sends the substance that has moved from the inner region to the outer region of the hollow fiber membrane within the blood filter to the drainage container. A pump control means for operating the dialysate pump, the blood pump, and the drainage pump, A reception means for receiving input of a first target cumulative volume of the dialysate supplied to the blood circuit and the patient's target treatment time, The system further comprises a calculation means for calculating the first pump flow rate of the dialysis fluid pump based on the first target cumulative amount and the target treatment time, The receiving means further accepts the setting registration operation for the first pump flow rate, provided that the first pump flow rate is within a predetermined first range. The pump control means, when the first pump flow rate is set and registered by the setting registration operation, operates the dialysate pump and the drainage pump based on the set and registered first pump flow rate, in a blood purification device.

2. Further comprising a replacement fluid pump that supplies replacement fluid to the blood circuit, The receiving means further receives the second target cumulative amount of the replacement fluid supplied to the blood circuit, The calculation means further calculates the second pump flow rate of the replenishment fluid pump based on the second target cumulative amount and the target treatment time. The receiving means accepts a setting registration operation for the first pump flow rate, the second pump flow rate, and the total amount, provided that the first pump flow rate is within the first range, the second pump flow rate is within a predetermined second range, and the sum of the first pump flow rate and the second pump flow rate is within a predetermined third range. The blood purification apparatus according to claim 1, wherein the pump control means, when the first pump flow rate, the second pump flow rate, and the total volume are set and registered by the setting registration operation, operates the dialysate pump based on the set and registered first pump flow rate, operates the replenishment fluid pump based on the set and registered second pump flow rate, and operates the drainage pump based on the set and registered total volume.

3. The receiving means further receives the target amount of fluid to be removed from the patient by the blood purification device, The calculation means further calculates the fluid removal rate based on the target fluid removal amount and the target treatment time, The receiving means further accepts a setting registration operation for the first pump flow rate, the water removal rate, and the total amount, provided that the first pump flow rate is within the first range, the water removal rate is within a predetermined second range, and the sum of the first pump flow rate and the water removal rate is within a predetermined third range. The blood purification apparatus according to claim 1, wherein the pump control means, when the first pump flow rate, the water removal rate, and the total amount are set and registered by the setting registration operation, operates the dialysate pump based on the set and registered first pump flow rate and operates the drainage pump based on the set and registered total amount.

4. Further comprising a replacement fluid pump that supplies replacement fluid to the blood circuit, The receiving means further receives the second target cumulative amount of the replacement fluid supplied to the blood circuit and the target amount of fluid to be removed from the patient by the blood purification device. The calculation means further calculates the second pump flow rate of the replenishment fluid pump based on the second target cumulative amount and the target treatment time, and the water removal rate based on the target water removal amount and the target treatment time. The receiving means accepts a setting registration operation for the first pump flow rate, the second pump flow rate, the water removal rate, and the total amount, provided that the first pump flow rate is within the first range, the second pump flow rate is within a predetermined second range, the water removal rate is within a predetermined third range, and the sum of the first pump flow rate, the second pump flow rate, and the water removal rate is within a predetermined fourth range. The blood purification apparatus according to claim 1, wherein, when the first pump flow rate, the second pump flow rate, the water removal rate, and the total amount are set and registered by the setting registration operation, the pump control means operates the dialysate pump based on the set and registered first pump flow rate, operates the replenishment fluid pump based on the set and registered second pump flow rate, and operates the drainage pump based on the set and registered total amount.

5. A control method for a blood purification device comprising a blood circuit, a dialysate pump, and a drainage pump, The blood circuit includes a hemofilter having a hollow fiber membrane and a blood pump that supplies blood to the hemofilter, the dialysate pump supplies dialysate to the outer region of the hollow fiber membrane within the hemofilter, and the drain pump sends substances that have moved from the inner region to the outer region of the hollow fiber membrane within the hemofilter to a drain container. A step of receiving input for the target cumulative volume of the dialysate supplied to the blood circuit and the patient's target treatment time, A step of calculating the pump flow rate of the dialysis fluid pump based on the target cumulative volume and the target treatment time, The steps include accepting a setting registration operation for the pump flow rate, provided that the pump flow rate is within a predetermined range, A control method for a blood purification device, comprising the steps of: when the pump flow rate is set and registered by the setting registration operation, operating the dialysate pump and the drainage pump based on the set and registered pump flow rate.

Images