Method and system for providing a fluid product mailer

Abstract

The folded mailer system (101) comprises a container (105) for holding a liquid and a structure (103) having at least two sections (102a, 104a) that fold together when the container is shipped. The container (105) and structure (103) are machinable in an automated mailer system.

Description

Technical Field

[0001] (Cross - reference to Related Applications) This application claims the benefit of priority of U.S. Provisional Application No. 63 / 268,148, filed on February 17, 2022, the content of which is incorporated herein by reference.

[0002] (Technical Field) All cited references in this specification are incorporated herein by reference in their entirety.

Background Art

[0003] For most product manufacturers, the shipping cost of products is a significant expense. If the shipping cost of a product approaches and / or exceeds 20% of the retail price of the product, such costs can potentially significantly erode the potential profit for the product manufacturer. In many cases, product manufacturers use private shipping carriers (e.g., United Parcel Service (UPS), FedEx, DHL, etc.), which is due to the fact that private shipping carriers can provide door - to - door service.

[0004] In the United States, private shipping carriers typically charge shipping fees that are three to five times or more compared to the First - Class postage rates set by the United States Postal Service (USPS). Generally, private shipping carriers are not permitted to deliver products to the postal receptacles of the USPS, so they charge higher fees to deliver products to the consumers' doorsteps.

[0005] On the other hand, product manufacturers can potentially significantly reduce shipping costs compared to private shipping carriers if they can utilize the First - Class postage rates of the USPS and provide "machine - processable" packages defined by the USPS. The First - Class postage rate (at the time of writing this article) is $0.42 per ounce and $0.17 per additional ounce. [See https: / / about.usps.com / postal - bulletin / 2007 / html / pb22218 / kit1_010.html].

[0006] The maximum size for "machine-processable" lettering under USPS First Class Mail rates is 11-1 / 2 inches x 6-1 / 8 inches x 1 / 4 inches in length x width x thickness. If any part of a USPS First Class Mail item exceeds any of the maximum dimensions of a letter-sized envelope, it will be classified and charged as a large envelope (flat). The maximum weight for a letter-sized envelope under USPS First Class Mail rates is 3.5 ounces (weight).

[0007] The USPS defines the following as common characteristics that make mail unsuitable for machine processing: mail with an aspect ratio (length divided by height) of less than 1.3 or greater than 2.5; mail containing hard or irregularly shaped items; mail with a delivery address parallel to the shorter side of the mail; and mail that is 6 inches or longer or 4-1 / 4 inches or taller if the thickness is less than 0.009 inches.

[0008] The non-rigidity requirement for machine-processable Class I mail is important. The USPS has this non-rigidity requirement because the sorting machines it uses each have a metal drum with a radius of approximately 5.5 inches. Class I mail is "non-rigid" if it can be bent around these metal drums to conform to its shape with this 5.5-inch radius.

[0009] Manufacturers of products that meet the requirements for USPS First Class Mail present a set of unique variables that must be resolved in order to ship their products using this cost-effective service. This set of variables becomes even more complex when a manufacturer ships fluid-type products. If a fluid-type product needs to be shipped via USPS First Class Mail, the container holding the fluid must not only prevent leakage from the container but also meet these stringent requirements.

[0010] Therefore, in this technical field, there is a need for methods and systems to create containers for fluid products that meet the stringent requirements set by the USPS when establishing Class I postage rates. Accordingly, there is a need in this technical field for compact, flexible envelopes for fluid products that can be "machine-processed" by the USPS or processed without human intervention during mailing or sorting. [Overview of the project]

[0011] The foldable mailer system can accommodate / seal containers containing liquids. The foldable mailer system meets the requirements / criteria set by the USPS for Class I machine-processed mail. While the foldable mailer system meets the requirements / criteria for Class I machine-processed mail of the USPS, it can also, though not limited to, meet the requirements / criteria for machine-processed mail in jurisdictions outside the United States, such as the United Kingdom, Germany, France, Spain, Italy, the Netherlands, Belgium, Australia, Japan, China, Taiwan, and the Russian Federation.

[0012] The mailer system may include a container capable of holding liquid and a structure for holding the container when it is being shipped. The structure may have at least two sections that fold together when the container is being shipped. The container and structure may be machine-processable within the automated mailer system.

[0013] One section of the structure may have an aperture for receiving a container. The structure may have a third section that folds over the first and second sections. When the container and structure are shipped, the structure may have a tri-fold configuration. Each section of the structure may have a removable part that is removed after the container and structure have been shipped, thereby allowing the container to be removed from the structure. The container may have a fluid outlet. The container may hold a fluid containing at least one of the following: fragrances, pheromones, cosmetics, pharmaceutical compositions, insecticides, or anthelmintic compositions (for use by animals, including humans). The container may also have a bottom plate. The structure of the system may have a flat sheet. The flat sheet may have multiple layers.

[0014] According to another exemplary embodiment, the mailer system may include a folded planar member and a container attached to the folded planar member. The container can seal a fluid. The mailer system may be mechanically processed by an automated mailer system that uses at least one drum to bend the mailer system around the drum.

[0015] The fluid in the container may comprise a topical composition for the treatment or prevention of external parasitic infections in animals. The external parasites include at least one of fleas, ticks, lice, and scabies. The fluid may also contain at least one of fragrances, pheromones, cosmetics for companion animals, or insecticides or anthelmintics.

[0016] The folded planar member may consist of multiple layers. Each layer may consist of at least one of the following: cardboard, varnish, or plastic film.

[0017] According to another exemplary embodiment, the mailer system may include a folded planar member and a container attached to the folded planar member. The container can seal a fluid. The folded planar member may further include an aperture for receiving the container. The mailer system may be mechanically processed by an automated mailer system that uses at least one drum to fold the mailer system around the drum.

[0018] This summary of the invention is provided in a simplified form to introduce selected concepts from those further described below in embodiments for carrying out the invention. This summary is not intended to identify the essential elements of the invention or to accurately describe the technical scope of the invention.

[0019] In drawings, reference numerals refer to the same part across different drawings unless otherwise indicated. Letter reference numerals, such as "102A" or "102B," can distinguish between two similar parts or elements present in the same drawing. The letter designation of a reference numeral may be omitted if it is intended to encompass all parts that share the same reference numeral in all drawings. For clarity, not all parts are shown in every drawing.

[0020] The term “exemplary” is used herein to mean “an example, case, or illustration.” No aspect described herein as “exemplary” shall necessarily be construed as exclusive, preferential, or advantageous over any other aspect. [Brief explanation of the drawing]

[0021] [Figure 1] This is a perspective view of a partially opened mailer system, which includes a foldable structure according to one exemplary embodiment. [Figure 2] This figure shows a fully open or open mailer system, with three sections substantially parallel to each other and the front sides of the sections visible. [Figure 3] A diagram showing a fully open or open mailer system where three sections are substantially parallel to each other and the rear side of the sections is visible. [Figure 4] An elevation view of a mailer system with three sections in a fully open or open state along with exemplary dimensions / sizes. [Figure 5A] A top view of a container according to one exemplary embodiment of the mailer system. [Figure 5B] A side view of the container 105 shown in FIG. 5A according to one exemplary embodiment. [Figure 6A-6B] FIG. 6A is a cross-sectional view of the container shown in FIGS. 5A - 5B, and FIG. 6B is an enlarged view of the section depicted in FIG. 6A. [Figure 7] A cross-sectional view of the mailer system when the mailer system is in a folded or closed state ready for transportation or mailing. [Figure 8] A cross-sectional view of the mailer system when the mailer system is positioned around the drum of an automatic sorting system and its shape is bent by the tension of the transport belt. [Figure 9] A cross-sectional view of the mailer system when the mailer system is in a folded or closed state and ready for transportation or mailing as in FIG. 7. [Figure 10] An elevation view of the mailer system showing the first step 2605 (refer to the flowchart of FIG. 26) of forming the mailer system. [Figure 11] An elevation view of the mailer system showing the second step 2610 (refer to the flowchart of FIG. 26) of forming the mailer system. [Figure 12] A diagram showing the third section being folded along the folding line so that its back side appears and is positioned on top of the second section. [Figure 13A] An elevation view of the mailer system showing the fourth step 2620 (refer to the flowchart of FIG. 26) of forming the mailer system. [Figure 13B] This is an elevation view of the mailer system, showing another version / embodiment of the fourth step 2620' (see flowchart in Figure 26) for forming the mailer system. [Figure 14] This is an elevation view of the mailer system, showing the sixth step 2630 (see flowchart in Figure 26) in forming the mailer system. [Figure 15] This is an elevation view of the mailer system, showing the seventh step 2635 (see flowchart in Figure 26) in forming the mailer system. [Figure 16] This is an elevation view of the mailer system, showing the eighth step 2640 (see flowchart in Figure 26) in forming the mailer system. [Figure 17] This is an elevation view of the mailer system, showing the ninth step 2645 (see flowchart in Figure 26) in forming the mailer system. [Figure 18A] This is an elevation view of the mailer system, showing another version / embodiment of the seventh step 2635' (see flowchart in Figure 26) for forming the mailer system. [Figure 18B] Figure 26 is an elevation view of the mailer system, showing another version / embodiment of step 7, 2635'. [Figure 19] This diagram shows how a single-layer sheet (unfolded) for a mailer system can be formed from a single layer of cardboard. [Figure 20] This figure shows that a flat sheet for a mailer system can be formed from two layers. [Figure 21] This is a diagram showing a two-layer sheet for a mailer system. [Figure 22] This figure shows a two-layer sheet for a mailer system. [Figure 23] This figure shows a two-layer sheet for a mailer system. [Figure 24] This is a cross-sectional view of a geometric planar sheet for a mailer system, made from three layers. [Figure 25]Another cross-sectional view of a geometric planar sheet for a mailer system made from three layers. [Figure 26] This figure shows a flowchart illustrating the method for forming the folded mailer system corresponding to Figures 10-18B. [Figure 27A] This is a top view of a container according to an exemplary embodiment of an alternative mailer system. [Figure 27B] This is a side view of the container shown in Figure 27A, according to an alternative exemplary embodiment. [Modes for carrying out the invention]

[0022] Referring to Figure 1, this figure shows a perspective view of a partially opened mailer system 101, comprising a folding structure 103 according to an exemplary embodiment of the system 101. The folding structure 103 has a first planar section 102a, a second planar section 104a, and a third planar section 106b. In Figure 1, the front side 102a of the first planar section 102 is visible, but only a small portion of the front side 104a of the second planar section 104 is visible. The rear side 106b of the third planar section 106 obstructs or covers most of the front side 104a of the second planar section 104. This rear side 106b has a curved edge 127, which is also shown in Figure 2 below.

[0023] The third planar section 106 has an aperture 107 having a shape substantially reflecting the shape of the container 105. According to one exemplary embodiment, the container 105 can contain or hold a fluid. However, as described below, the container can contain a solid or semi-solid material.

[0024] When in fluid form, the fluid may include topical compositions for the treatment or prevention of external parasitic infections and / or infections in animals (i.e., treatment and / or prevention of fleas, ticks, lice, scabies and / or nematodes and filariasis in companion animals). In one embodiment, the animal may be a companion animal. Companion animals include, but are not limited to, dogs and cats. However, other types of drug formulations are also possible and are included in the scope of this disclosure, some of which are described in detail below.

[0025] Other fluids in container 105 may include fragrances, pheromones, cosmetics, insecticides, pharmaceutical compositions, or fluids for various other uses for humans. Furthermore, as described above, container 105 can enclose or contain objects other than fluids. For example, container 105 can contain soft chewing compositions, tablets / pharmaceuticals, gels, lotions, pastes, electronic chips such as transponders for companion animals, or memory chips for personal computer devices (i.e., wireless phones, laptops, cameras, etc.).

[0026] In other embodiments, container 105 can hold various other types of pharmaceutical compositions and dosage forms. For example, in one exemplary embodiment, container 105 can hold a pharmaceutical composition comprising an effective amount of at least one active ingredient or a salt thereof, in combination with an acceptable carrier or diluent. The pharmaceutical composition can be in various liquid and solid forms suitable for various methods of application or administration to animals.

[0027] As another example, the pharmaceutical composition may contain one or more active ingredients that are suitable for oral administration, injection administration including subcutaneous and parenteral administration, topical administration (e.g., spot-on or pour-on), and topical administration including skin or subcutaneous administration. Those skilled in the art will understand that the shape and size of the drug dosage form may be adapted to fit into the container 105 of the present invention.

[0028] A suitable topical spot-on or pour-on formulation composition may contain a pharmaceutically effective amount of at least one active ingredient in a pharmaceutically acceptable carrier or diluent. Examples of pharmaceutically acceptable carriers or diluents for topical compositions include, but are not limited to, solvents and solvent mixtures, penetration enhancers, surfactants, antioxidants, pH stabilizers, preservatives, and crystallization inhibitors well known in the art.

[0029] In other exemplary embodiments, container 105 can hold compositions suitable for oral administration to animals. Suitable drug forms for oral administration include nutritional supplements, lozenges, chewables (e.g., chewable tablets or soft chewables), tablets, hard or soft capsules, boluses, emulsions, aqueous or oily suspensions, aqueous or oily solutions, compositions for oral administration, dispersible powders or granules, premixes, syrups or elixirs, enteric-coated compositions or pastes. In one embodiment, a flattenable, chewable paste or gum for oral administration may be included in the container. The size and shape of the flattenable, chewable paste can be adapted to fit the size and shape of container 105. Pharmaceutical compositions intended for oral use can be prepared according to any method well known in the art in the manufacture of pharmaceutical compositions. For example, suitable tablets can be obtained by mixing one or more active agents with known excipients such as inert diluents, carriers, disintegrants, adjuvants, surfactants, binders and / or lubricants.

[0030] In another exemplary embodiment of the present invention, the container 105 may be provided with a soft chewing veterinary composition comprising an effective amount of at least one activator in a pharmaceutically acceptable carrier.

[0031] Container 105 may contain various activators and combinations of activators, along with a pharmaceutically acceptable carrier or diluent. In one embodiment, the active ingredient may contain one or more arylpyrazole compounds, such as phenylpyrazole insecticides known in the art. Phenylpyrazole insecticides act by blocking glutamate-gated chloride channels (GABAA gate chloride) in insects. Examples of such phenylpyrazole compounds include, but are not limited to, those described in U.S. Patents 6,001,384, 6,010,710, 6,083,519, 6,096,329, 6,174,540, 6,685,954, and 6,998,131 (all incorporated herein by reference). One particular phenylpyrazole compound that may be included is fipronil.

[0032] In another embodiment of the present invention, container 105 may contain one or more macrocyclic lactones that act as acaricides, anthelmintics, and / or insecticides. The macrocyclic lactones include both avermectins and milbemycins, which are active agents. Avermectins include, but are not limited to, abamectin, dimadectin, doramectin, emamectin, eprinomectin, ivermectin, latidectin, lepimectin, and selamectin. Milbemycins include, but are not limited to, milbemectin, milbemycin D, milbemycin oxime, moxidectin, and nemadectin. Also included are 5-oxo derivatives and 5-oxime derivatives of the avermectins and milbemycins.

[0033] In another embodiment, the activator in container 105 may be one or more molecules of a type of insecticide known as insect growth regulators (IGRs). Compounds belonging to this group are well known to those skilled in the art and represent a wide range of different chemical classes. All of these compounds act by inhibiting the growth or development of pests. Insect growth regulators are described, for example, in U.S. Patents 3,748,356, 3,818,047, 4,225,598, 4,798,837, 4,751,225, European Patent No. 0179022 or British Patent No. 2140010, and U.S. Patents 6,096,329 and 6,685,954 (all incorporated herein by reference).

[0034] In one embodiment, container 105 may contain an IGR (juvenile hormone mimetic) that mimics juvenile hormone. Examples of juvenile hormone mimetic substances include azadirachtin, diphenolane, phenoxycarb, hydroprene, quinoprene, (S)-methoprene, pyriproxyfen, tetrahydroazadirachtin, and 4-chloro-2(2-chloro-2-methylpropyl)-5-(6-iodo-3-pyridylmethoxy)pyridazine-3(2H)-one.

[0035] In another embodiment, the IGR compound in container 105 may include a chitin synthesis inhibitor. The chitin synthesis inhibitor acts by interfering with the insect's molting process. Chitin synthesis inhibitors include, but are not limited to, chlorofluazurone, cyromazine, diflubenzuron, fluazurone, flucycloxurone, flufenoxurone, hexafluorone, lufenuron, tebufenozide, teflubenzuron, triflumorone, novalon, 1-(2,6-difluorobenzoyl)-3-(2-fluoro-4-(trifluoromethyl)phenylurea, 1-(2,6-difluorobenzoyl)-3-(2-fluoro-4-(1,1,2,2-tetrafluoroethyl)phenylurea, 4-(trifluoromethyl)phenylurea, 1-(2,6-difluorobenzoyl)-3-(2-fluoro-4-(1,1,2,2-tetrafluoroethoxy)phenylurea, and 1-(2,6-difluorobenzoyl)-3-(2-fluoro-4-trifluoromethyl)phenylurea.

[0036] In yet another embodiment, the activator in container 105 may include one or more pyrethrin or pyrethroid insecticides and / or acaricides. These include synerin I, synerin II, jasmolin I, jasmolin II, pyrethrin I, pyrethrin II and mixtures thereof, as well as permethrin, cyhalothrin, cypermethrin, cyphenothrin, deltamethrin, dimefluthrin, esfenvalerate, etofenprox, fenvalerate, fenpropatrin, flucitrinate, flumethrin, imiprothrin, lambda-cyhalothrin, metofluthrin, phenothrin, prallethrin, resmethrin, silafluofen, tau-fluvalic acid, tefluthrin, tetramethrin, tralomethrin and transfluthrin. Suitable carbamates include, but are not limited to, benoxal, carbanolates, carbaryl, carbofuran, mesothiocarb, methocarb, promacil, propoxul, aldicarb, butocarboxim, oxamyl, thiocarboxim, and thiophanox.

[0037] In some embodiments, the activator contained in container 105 may be one or more antinematode agents comprising, but not limited to, activators from the group of compounds including benzimidazoles, imidazothiazoles, tetrahydropyrimidines, and organophosphates. In some embodiments, the benzimidazoles include, but are not limited to, thiobendazole, cambendazole, parbendazole, oxybendazole, mebendazole, flubendazole, fenbendazole, oxfendazole, albendazole, cyclobendazole, febantel, thiophanates, and their o,o-dimethyl analogs.

[0038] In other embodiments, the activator in container 105 may be an imidazothiazole compound, including but not limited to tetramizole, levamizole, and butamizole.

[0039] In further embodiments, the activator in container 105 may be a tetrahydropyrimidine activator, including, but not limited to, pyrantel, oxatel, and morantel.

[0040] Suitable organophosphorus activators that can be transported by container 105 include, but are not limited to, coumaphos, trichlorfon, halophos, naphthalophos and dichlorvos, heptenophos, mevinphos, monoclotophos, TEPP and tetrachlorvinphos.

[0041] In other embodiments, the activator in container 105 may be phenothiazine and piperazine as neutral compounds, or cyanine dyes in various salt forms, such as phenols including diethylcarbamazine and diphenol, arsenic compounds including arsenic amide, ethanolamines including befenium, crosylated thionine, and cyanine pigments including pyrivium chloride, pyrivium pamoate, and dithiazanine iodide; and isothiocyanates containing various natural products including, but not limited to, vitoscanic acid, suramin sodium, phthalofine, and hygromycin B, α-santonin, and kainic acid.

[0042] In another embodiment, container 105 may contain an antitrematode. Suitable antitrematodes include, but are not limited to, miracil derivatives such as miracil D and mirasan; various bisphenol compounds known in the art, including praziquantel, clonazepam and its 3-methyl derivatives, orthopyrazole, rucannon, hicannon, oxaminxin, amoscarnate, niridazole, nitroxinyl, hexachlorophene, bithionol, bithionol sulfoxide and meniclophoran; various salicylanilide compounds, including tribromusaran, oxyclozanide, cloxanide, lafoxanide, brothianide, bromoxanide and closantel; and triclabendazole, diafenthiode, chlorthrone, hechtriin and emetine.

[0043] Antidiarrheal drugs may also be included in container 105, but are not limited to, arecolin, bunamidine, niclosamide, nitroscanates, paromomycin, and paromomycin II in various salt forms.

[0044] In further embodiments, container 105 may contain an activator effective against arthropod parasites. Suitable activators include, but are not limited to, bromocyclene, chlordane, DDT, endosulfan, lindane, methoxychlor, toxafen, bromophos, bromophosethyl, carbophos, chlorfenvinphos, chlorpyrifos, clotoxyphos, cythionate, diazinon, dichlordane, dimethoate, dioxathion, ethion, fenpros, fenitrothion, fenthion, phosphamidone, fosmet, phosphoryl, malathion, and na Red, fenpropathrin, propethamphos, propetofos, propadium, profenofos, profenfos, promethazine, prometrin, piperofos, pyridafen, pyrimiphosmethyl, pyrethroid, pyrethrin, linaclotilide, limeprothrin, rofecoxib, loramethrin, loratrin, lorifenyl, chlordane, chlordane, chlordane, chlordane, chlordane, chlordane, chlordane, chlordane, chlordane, chlordane Chlordane, chlordane, chlordane, chlordane, chlordane, chlordane, fenvalerate, flucitrinate, permethrin, phenothrin, pyrethrin, resmethrin, benzyl benzoate, carbon disulfide, crotamiton, diflubenzuron, diphenylamine, disulfiram, isobornylthiocyanate, methoprene, monosulfamide, pyrenonyl butoxide, rotenone, triphenyltin acetate, triphenyltin hydroxide, diethyl Examples include toluamide, dimethyl phthalate, and compounds 1,5a,6,9,9a,9b-hexahydro-4a(4H)-dibenzofrancarboxaldehyde (MGK-11), 2-(2-ethylhexyl)-3a,4,7,7a-tetrahydro-4,7-methano-1H-isoindole-1,3(2H)dione (MGK-264), dipropyl-2,5-pyridinedicarboxylate (MGK-326), and 2-(octylthio)ethanol (MGK-874).

[0045] Other antiparasitic agents that may be included in Container 105 include, but are not limited to, biologically active peptides or proteins, including cyclic depsipeptides, that act at the neuromuscular junction by stimulating presynaptic receptors belonging to the xixidin receptor family, resulting in paralysis and death of parasites. In one embodiment, the cyclic depsipeptide is an octacyclodepshipeptide such as emodepside or PF1022A (see Willson et al., Parasitology, Jan. 2003, 126(Pt 1):79-86). In another embodiment, the cyclooctadepshipeptide is an activator described in U.S. Patents 10,081,656 and 10,344,056 (both incorporated herein by reference).

[0046] In another embodiment, a neonicotinoid activator of the pesticide may be included in container 105. Neonicotinoids bind to and inhibit nicotinic acetylcholine receptors in insects. In one embodiment, the neonicotinoid insecticide is imidacloprid. Imidaclopride is a well-known neonicotinoid activator and is the main active ingredient in the topical antiparasitic products marketed by Elanco Animal Health, Inc., Advantage®, Advantage® II, K9 Advantics®, and K9 Advantics® II. This class of agents is described, for example, in U.S. Patent No. 4,742,060 or European Patent No. 0892060 (incorporated herein by reference).

[0047] In another embodiment, the neonicotinoid activator transported by container 105 is nitenpyram. Nitenpyram is the active ingredient in CAPSTAR® Tablets, an oral product marketed by Novartis Animal Health. When administered daily as an oral tablet, nitenpyram acts on adult fleas. Nitenpyram acts by interfering with normal neurotransmission, leading to the death of the insects. Nitenpyram acts very rapidly on fleas. For example, CAPSTAR® tablets begin to act on fleas as early as 30 minutes after administration, making once-daily use suitable.

[0048] In another embodiment, the insecticide that can be included in the container 105 of the present invention is a semicarbazone such as metaflumizone.

[0049] In another embodiment, isoxazoline compounds well known in the industry may be contained in container 105. These isoxazoline activators are U.S. Patent Nos. 7,964,204, 8,410,153, 2011 / 0152312, 2010 / 0254960A1, 2011 / 0159107, 2012 / 0309620, 2012 / 030841, 2010 / 069247, WO2007 / 125984, WO2012 / 086462, 8,318,757, 2011 / 144349, U.S. Patent No. 8,053452; U.S. Patent No. 2010 / 0137612, U.S. Patent No. 2010 / 0254959, U.S. Patent No. 2011 / 152081, WO2012 / 089623, WO2012 / 089622, U.S. Patent No. 8,119,671; U.S. Patent No. 7947,715; WO2102 / 120135, WO2012 / 107533, WO2011 / 157748, U.S. Patent No. 2011 / 0245274, U.S. Patent No. 2011 / 0245239, U.S. Patent No. 2012 / 23202 No. 6, U.S. Patent No. 2012 / 077765, U.S. Patent No. 2012 / 035122, U.S. Patent No. 2011 / 251247, WO2011 / 154433, WO2011 / 154434, U.S. Patent No. 2012 / 238517, U.S. Patent No. 2011 / 166193, WO2011 / 104088, WO2011 / 104087, WO2011 / 104089, U.S. Patent No. 2012 / 15946, U.S. Patent No. 2009 / 143410, WO007 / 123855A2, U.S. Patent No. 2011 / 11 U.S. Patent Nos. 8212, 7951828 & 7662972, 2010 / 0137372A1, 2010 / 0179194A2, 2011 / 0086886A2, 2011 / 0059988A1, 2010 / 0179195A1, 7,897,630, 7,951,828 and 7,662,972 are all incorporated herein by reference.

[0050] Examples of isoxazoline compounds that can be transported by container 105 include, but are not limited to, afoxolane ether, esafoxolane ether, umifoxolane ether, fluralaner, salalan, and rotilan.

[0051] In another embodiment of the present invention, nodurispolinic acid and its derivatives (a group of compounds known as acaricides, anthelmintics, antiparasitic agents, and insecticides) may be included in container 105. These compounds are used for the treatment or prevention of infections in humans and animals and are described, for example, in U.S. Patents 5,399,582, 5,962,499, 6,221,894, and 6,399,786, all of which are incorporated herein by reference in their entirety.

[0052] In another embodiment, an aminoacetonitrile (AAD) anthelmintic compound, such as monopantel (ZOLVIX), may be included in container 105. These compounds are described, for example, in WO2004 / 024704 and U.S. Patent No. 7,084,280 (incorporated by reference); Sager et al., Veterinary Parasit 2009, 159, 49-54; Kaminsky et al., Nature vol. 452, March 13, 2008, 176-181.

[0053] The container 105 of the present invention may contain arylazole-2-ylcyanoethylamino compounds as described in U.S. Patent No. 8,088,801, incorporated herein by reference, and thioamide derivatives of these compounds as described in U.S. Patent No. 7,964,621, incorporated herein by reference.

[0054] Paraherquamide compounds and derivatives of these compounds, such as derquantel (see Ostlind et al., Research in Veterinary Science, 1990, Vol. 48, pp. 260-261; and Ostlind et al., Medical and Veterinary Entomology, 1997, Vol. 11, pp. 407-408), may also be included in container 105. Parahexamide compounds are a type of compound known to contain a spirodioxepinoindole core that acts against specific parasites (see Tet. Lett. 1981, 22, 135; J. Antibiotics 1990, 43, 1380, and J. Antibiotics 1991, 44, 492). Furthermore, structurally related malforin compounds, such as malforin AC, are also known and can be combined with the formulations of the present invention (see J. Chem. Soc. - Chem. Comm. 1980, 601 and Tet. Lett. 1981, 22, 1977). Further references relating to parahexamide derivatives are, for example, WO91 / 09961, WO92 / 22555, WO97 / 03988, WO01 / 076370, WO09 / 004432, U.S. Patent No. 5,703,078, and U.S. Patent No. 5,750,695, all of which are incorporated herein by reference.

[0055] In certain embodiments, container 105 may have a combination of the phenylpyrazole compound fipronil and (S)-methoprene. This combination of activators is included in the companion animal product "Frontline® Plus" which is available on the market at the time of writing this specification.

[0056] In another embodiment, container 105 may have a combination of fipronil, (S)-methoprene, and pyriproxyfen. This combination of activators is available in Frontline® Gold, a companion animal medication for dogs, which is available on the market at the time of writing this specification.

[0057] In another embodiment, container 105 may have a combination of the phenylpyrazole activators fipronil, permethrin, and pyriproxyfen. This combination of activators is available in Frontline® Shield, a companion animal drug for dogs that is available on the market at the time of writing this specification.

[0058] In another embodiment, container 105 may have a combination of the phenylpyrazole compound fipronil and permethrin. This combination of activators is present in Frontline Triact® / Frontect®, a companion animal therapeutic product available on the market at the time of writing this specification.

[0059] Container 105 is removable from the aperture 107 of the third section 106. Container 105 is removably fixed to the front side 104a of the second section 104 using a peelable gel adhesive or an equivalent fastening method that would be understood by those skilled in the art.

[0060] In the perspective view of Figure 1, the front side 102a of the front section 102 is visible, and the rear side 106b of the third section 106 is fully exposed. Because the third section 106 is folded over the front portion 104a of the second section 104, only a small portion of the front portion 104a of the second section 104 is visible. Furthermore, the front portion 102a of the first section 102 is either "open" or lifted upward relative to the rear portion 106b of the third section 106. As shown in Figure 1, the second section 104 and the third section 106 can be described as being "closed" or "folded" relative to each other, while the first section 102 relative to the third section 106 can be described as being "open" or "unfolded".

[0061] Each section 102, 104, and 106 may further comprise text consisting of alphanumeric human-readable text and machine-readable elements (i.e., 2D barcodes). Human-readable text / characters and / or machine-readable elements may further describe the contents of container 105 and / or how consumers use the contents of container 105.

[0062] Next, referring to Figure 2, this figure shows the mailer system 101 in a state that is not fully open or folded, where the three sections 102, 104, and 106 are substantially parallel to each other, and the fronts 102a, 104a, and 106a of the three sections 102, 104, and 106 are visible. In this figure, the container 105 (see Figure 1) has been removed from the system 101, but the aperture 107 is still visible. As mentioned above, the aperture 107 has a shape that substantially reflects the shape of the container 105. The aperture 107 is slightly larger than the container 105 so that it can enclose the container 105 and hold the container 107 when the mailer system 101 is folded or closed.

[0063] In Figure 2, additional sections 202 are visible compared to Figure 1. In Figure 1, these sections 202 are removed and not present. Sections 202a-g may be removed or torn along the dashed lines shown in Figure 2 and exist along three sections 102, 104, and 106. Sections 202a-g are generally present when the mailer system 101 is folded or closed. Typically, an adhesive (not visible in Figure 2) can be applied to sections 202 immediately before the mailer system 101 is folded.

[0064] Section 202 containing adhesive is generally removed from the mailer system 101 after the mailer system 101 has been transported or shipped to the consumer. As described above, section 202 containing adhesive may be removed along the cutting or dashed lines shown in Figure 2. In view of Figure 2, the front sides 102a, 104a, and 106a of the first, second, and third sections 102, 104, and 106 are visible. The front side 102a may have text and / or graphics 133. In this exemplary embodiment, the graphics 133 depict a companion animal (i.e., a dog).

[0065] The curved edge 127 in Figure 2 is the same curved edge 127 shown in Figure 1 above. As shown in Figure 1, the front side 106a of the third section 106 is folded over to cover the front side 104a of the second section 104. Because the front 106a of the third section 106 is folded over the second section 104, the curved edge 127 is close to the front 102a of the first section 102.

[0066] Next, referring to Figure 3, this figure shows the mailer system 101 in a fully open or extended state, where the three sections 102, 104, and 106 are substantially parallel to each other, and the rear sides 102b, 104b, and 106c of the three sections 102, 103, and 106 are visible. Since Figure 3 is similar to Figure 2, only the differences between these two figures will be described here. In Figure 3, it is shown that the container 105 is located within the aperture 107. Typically, the container 105 is attached to the front 104a of the second section 104, as shown in Figure 1.

[0067] Each of the reverse sides 102b, 104b, and 106b of sections 102, 104, and 106 may have distinct, human-readable alphanumeric text and machine-readable elements, similar to the front sides 102a, 104a, and 106a. These elements may include the mailing address and stamps or U.S. postal permit, which may be printed directly on the mailing or on a paper label attached to the mailing using adhesive. The text and / or machine-readable elements on the reverse sides 102b, 104b, and 106b may be different from, similar to, and / or identical to the information presented on the front sides 102a, 104a, and 106a.

[0068] Referring now to Figure 4, this figure shows an elevation view of the mailer system 101 with three sections 102, 104, and 106 in a fully open or open position, along with exemplary dimensions / sizes. The dimensions illustrated in Figure 4 are expressed in millimeters. However, other sizes and / or shapes are possible and are within the scope of this disclosure. As those skilled in the art will understand, other sizes may be smaller or larger than those shown in Figure 4.

[0069] As stated above, the size and / or shape of Mailer System 101 should meet the "machine-processable" requirements set by the USPS for Class I postage. While Mailer System 101 meets the USPS requirements / criteria for Class I machine-processable mail, it may also meet the requirements / criteria for machine-processable mail in other jurisdictions outside the United States, including, but not limited to, the United Kingdom, Germany, France, Spain, Italy, the Netherlands, Belgium, Australia, Japan, China, Taiwan, and the Russian Federation.

[0070] Referring next to Figure 5A, this figure shows a top view of a container 105 according to one exemplary embodiment of the mailer system 101. Exemplary dimensions in millimeters (mm) are also shown in Figure 5A (see the mm dimensions between the multiple arrows in the figure). As with Figure 4, other sizes and / or shapes are possible and are within the scope of this disclosure. As will be understood by those skilled in the art, other sizes may be smaller or larger than those shown in Figure 5A. As stated above, the size and / or shape of mailer system 101 should meet the "machine-processable" requirements set by the USPS for first-class postage.

[0071] Container 105 may be provided with alphanumeric text and / or machine-readable elements 504. The text and / or elements 504 may include brand information such as trademarks or trade names. The container may further be provided with an outlet 502 from which liquid (invisible) inside container 105 can drain out when the edge of the outlet 502 is cut and / or removed.

[0072] As shown in Figure 5B, the container 105 has an end portion 507. The container 105 further has a bottom plate 511 to which the end portion 507 is coupled. The bottom plate 511 further has an edge portion 509. According to this exemplary embodiment in Figure 5B, the distance between the end portion 507 and the edge portion 509 of the bottom plate 511 is approximately 5.5 mm. This dimension is given because various dimensions of the container 105 can be adjusted as desired, as shown in Figures 27A-27B and as will be described below.

[0073] Referring now to Figure 5B, this figure is a side view of the container 105 shown in Figure 5A according to one exemplary embodiment. Figure 5B also provides exemplary dimensions, but these are not limited to those shown. As mentioned above, in order to meet the USPS requirements for machine-processable Class 1 mail, the height of the container 105 must be less than 1 / 4 inch. In order to meet the USPS requirements for machine-processable Class 1 mail, the combined thickness of the cardboard mailer 101 and the container 105 must typically be less than 1 / 4 inch.

[0074] Therefore, the height of a container 105 must typically be less than 1 / 4 inch, taking into account the thickness of the mailer cardboard at the top and bottom of the container 105. However, other sizes smaller or larger are also possible and within the scope of this disclosure. Larger sizes may cause a container 105 to fall outside the requirements for U.S. First Class Mail. However, under certain circumstances, this may be permissible if U.S. First Class Mail is undesirable and / or if the container is shipped / mailed outside the United States and the non-U.S. jurisdiction does not adhere to First Class Mail requirements. For example, these other jurisdictions, such as the United Kingdom, Germany, France, Spain, Italy, the Netherlands, Belgium, Australia, Japan, China, Taiwan, and the Russian Federation, may not adhere to U.S. First Class Mail requirements.

[0075] Next, referring to Figure 6A, this figure shows a cross-sectional view of the container 105 shown in Figures 5A-5B. In Figure 6A, the edge section 602 of the container 105 is visible. Next, referring to Figure 6B, this figure shows an enlarged view of the edge section 602 depicted in Figure 6A. The edge section 602 of the container 105 may have an upper section 604 and a bottom section 606. The upper section 604 in Figure 6B may comprise a multilayer structure.

[0076] More specifically, the upper section 604 may include multiple layers, for example, (but not limited to) (external atmosphere adjacent to container 105) > polypropylene-cycloolefin copolymer-polypropylene / polyethylene-ethylene vinyl alcohol-polyethylene > (the polyethylene layer is the innermost layer in contact with the liquid inside container 105), in this exemplary order. The abbreviation for the multilayer structure of the upper section 604 is PP-COC-PP / PE-EVOH-PE. However, other materials and combinations of materials are also possible and are included in the scope of this disclosure.

[0077] The lower section 606, like the upper section 604, may also comprise a multilayer structure. More specifically, the bottom section 604 may include multiple layers, for example, (but not limited to) (ambient air outside the container 105) > printing ink > polyethylene terephthalate / aluminum / polyethylene-ethylene vinyl alcohol-polyethylene > (the polyethylene layer is the innermost layer in contact with the liquid inside the container 105), in this exemplary order. The abbreviation for the multilayer structure of the bottom section 606 is PET / Alu / PE-EVOH-PE. However, other materials and combinations of materials are also possible and are included in the scope of this disclosure.

[0078] Referring to Figure 7, this figure shows a cross-sectional view of the mailer system 101 when it is in a folded or closed state, ready for transport or mailing. Specifically, the three sections 102, 104, and 106 are folded and stacked as follows, with the second intermediate section 104 at the bottom, the third section 106 above the intermediate section 104 (see Figure 2-3 for the sections in their unfolded state), and the first section above the third section 106. Thus, from horizontal to vertical in Figure 7, the sections are 104, 106, and 102. However, other orders and / or stackings of the three sections 102, 104, and 106 are also possible and are included in the scope of this disclosure, as will be understood by those skilled in the art.

[0079] Next, referring to Figure 8, this figure shows a cross-sectional view of the mailer system 101 when positioned on the outer circumference of the drum 800 of the automated mail sorting system. As anyone skilled in the art familiar with automated mail sorting systems will understand, the mailer system 101 is curved due to the tension of the conveyor belt 810.

[0080] Specifically, this figure shows how the mailer system 101 deflects around the drum 800 as it moves through the automated mail sorting system. According to one example embodiment, the drum 800 has a radius of approximately 5.5 inches, as specified by the USPS.

[0081] As any typical engineer in the field of automated mail sorting systems would understand, for mail and its contents to be transported by automated mail processing machines, they must bend easily when subjected to a transport belt tension of approximately 40.0 pounds around the circumference of an 11.0-inch diameter drum. In other words, for US mail, the bending radius is generally 5.5 inches or more. 5.5 inches is approximately 140.0 mm. In Europe, the diameter of each drum is approximately 280.0 mm (e.g., Siemens brand sorting machines) or approximately 300.0 mm (e.g., Neopost sorting machines).

[0082] Other radii are also possible and are included within the scope of this disclosure. Other radii may be larger or smaller than the illustrated radii, as will be understood by those skilled in the art.

[0083] Next, referring to Figure 9, this figure shows a cross-sectional view of the mailer system 101 when it is in a folded or closed state, ready for transport or mailing, similar to Figure 7. In Figure 9, the container 105 is clearly indicated at the geometric center of the folded mailer system 101. The maximum height of the mailer system 101 is also at the geometric center, and this height generally does not exceed 0.25 inches in order to meet the USPS Class 1 mail standards mentioned above.

[0084] However, other sizes smaller or larger are also possible and within the scope of this disclosure. Other sizes larger than this may cause Container 105 to fall outside the requirements for U.S. First Class Mail. However, this may be permissible under certain circumstances if the requirements for U.S. First Class are undesirable and / or if the container is shipped / mailed to a region outside the United States and the non-U.S. jurisdiction does not comply with First Class requirements.

[0085] Next, referring to Figure 10, this figure is an elevation view of the mailer system 101 and shows the first step 2605 (see flowchart in Figure 26) of forming the mailer system 101. In this first step 2605, the mailer system is formed by at least three perforations or cut lines 1005, 1015, and 1020. Sections 202a-202g can be removed later along these cut lines 1005, 1015, and 1020, as will be described below. In this first step 2605 shown in Figure 10, an aperture 107 is also formed. Furthermore, two fold lines 1022a and 1022b may be formed to form three sections 102a, 104a, and 106a of the tri-fold portion. As described above, the aperture 107 generally has a shape substantially similar to that of the container 105 (see Figure 5A). However, as mentioned above, aperture 107 generally has a larger circumference than the outer circumference of container 105.

[0086] Furthermore, the cut line 1015 may have a curved shape. However, in other exemplary embodiments, the cut line 1015 may have a different shape, such as being straight or any other shape as will be understood by those skilled in the art.

[0087] Next, referring to Figure 11, this figure is an elevation view of the mailer system 101 and shows the second step 2610 (see flowchart in Figure 26) of forming the mailer system 101. Figure 11 is substantially similar to Figure 10. Therefore, only the differences between Figure 10 and Figure 11 will be described here. In Figure 11, a container 105 may be formed having a shape substantially similar to that of the aperture 107. The container 105 is positioned on the tri-folded second section 104a such that the aperture 107 aligns with the outer periphery of the container 105 when the third section 106a is folded over the second section 104a. Thus, in Figure 11, the container 105 is positioned mirror-image or inverted with respect to the folding line 1022b and the aperture 107. Container 105 is attached to the mailer system 101 using a peelable adhesive such as gel glue, or a functionally equivalent, such as a fastening device or mechanism (i.e., tape, staples, openings / slits in the supporting surface, etc.).

[0088] Next, referring to Figure 12, this figure is an elevation view of the mailer system 101 and shows the third step 2615 (see flowchart in Figure 26) that forms the mailer system 101. Figure 12 is substantially the same as Figure 11. Therefore, only the differences between Figure 12 and Figure 11 will be explained here.

[0089] In Figure 12, the third section 106a is folded along the folding line 1022b, with its reverse side 106b visible, and positioned above the second section 104a. The curved edge 127 of the third section 106a is close to the front surface 102a of the third section 102. The aperture 107 is positioned above the container 105, which is indicated by a dashed line 105 in this figure. The third section 102a remains in the same position as in Figure 11.

[0090] Next, referring to Figure 13A, this figure is an elevation view of the mailer system 101 and shows the fourth step 2620 (see flowchart in Figure 26) that forms the mailer system 101. Figure 13A is substantially similar to Figure 12. Therefore, only the differences between Figure 13A and Figure 12 will be explained here.

[0091] In this diagram, the mailer system 101 is rotated 90 degrees counterclockwise (90°) compared to the diagram in Figure 12. The third section 102 is folded along the folding line 1022a, with its reverse side 102b now visible, and overlapping the container 105 (not visible in Figure 13A). Meanwhile, the front 102a of the third section 102 is shown in Figure 12. In Figure 13A, the perforations 1005, 1015, and 1020 are also visible.

[0092] Next, referring to Figure 13B, this figure is an elevation view of the mailer system 101 and shows another version / embodiment of the fourth step 2620' (see flowchart in Figure 26) that forms the mailer system 101. Figure 13B is substantially similar to Figure 13A. Therefore, only the differences between Figure 13A and Figure 13B will be described here.

[0093] In Figure 13B, the cut line 1015' is straight compared to the cut line 1015 in Figure 13A. In Figure 13A, the cut line 1015 is curved. Therefore, as those skilled in the art will understand, each of the cut lines or perforations 1005, 1015, 1015', and 1020 may have a shape different from the illustrated shape, and these different shapes are within the scope of this disclosure.

[0094] The mailer systems 101 and 101' in Figures 13A and 13B are closed and can accept first-class postage stamps / postmarks 1402 etc. (see Figure 14) in the fifth step 2625 of Method 2600 (see Figure 26). Furthermore, the mailer systems 101 and 101' can accept alphanumeric text and / or machine-readable codes providing a mailing address 1404 (see Figure 14). In this fifth step 2625, the mailer systems 101 and 101' are “machine-processed” and can be processed by the drum 800 illustrated in Figure 8. Thus, in this fifth step 2625 of Method 2600, the mailer systems 101 and 101' are flexible or bendable around the drum 800 shown in Figure 8 during automated sorting used by the USPS and other jurisdictions / entities.

[0095] Next, referring to Figure 14, this figure is an elevation view of the mailer system 101 and shows the sixth step 2630 (see flowchart in Figure 26) that forms the mailer system 101. Figure 14 is substantially the same as Figure 13A. Therefore, only the differences between Figure 13A and Figure 14 will be explained here.

[0096] In Figure 14 and step 2630, the mailer system 101 is received by a consumer located at mailing address 1404, and the consumer can open the mailer system 101 by removing two sections 202a and 202b along perforations 1005 and 1020.

[0097] Next, referring to Figure 15, this figure is an elevation view of the mailer system 101 and shows the seventh step 2635 (see flowchart in Figure 26) that forms the mailer system 101. Figure 15 is substantially the same as Figure 14A. Therefore, only the differences between Figure 15 and Figure 14 will be explained here.

[0098] Compared to Figure 14, the mailer system 101 in Figure 15 is rotated approximately 90 degrees (90°) clockwise. The third section 102a of the tri-fold structure is in an "opened" state by opening the opening 102a along the curved cut line 1015 and unfolding the fold along the fold line 1022a. In Figure 15, the inner third section 102a and the inner second section 104a are visible. The outer first section 106b can also be seen in Figure 15. As described above, the container 105 is held to the front surface 104a of section 104 by an adhesive such as gel glue.

[0099] Next, referring to Figure 16, this figure is an elevation view of the mailer system 101 and shows the eighth step 2640 (see flowchart in Figure 26) that forms the mailer system 101. Figure 16 is substantially the same as Figure 15. Therefore, only the differences between Figure 16 and Figure 15 will be explained here.

[0100] In Figure 16, the third section 106a is "opened" by unfolding it along the folding line 1022b. All three tri-fold front sections 102a, 104a, and 106a can be seen in Figure 16. The aperture 107 of the first tri-fold section 106a is diametrically opposed to the container 105 located in the second tri-fold section 104a. The container 105 is ready to be removed from the mailer system 101. Specifically, the container 105 can be removed from the mailer system 101 by using peelable gel glue to pull it away from the front surface 104a of section 104. The glue will also typically remain on the front surface 104a of section 104.

[0101] Next, referring to Figure 17, this figure is an elevation view of the mailer system 101 and shows the ninth step 2645 (see flowchart in Figure 26) that forms the mailer system 101. Figure 17 is substantially the same as Figure 16. Therefore, only the differences between Figure 17 and Figure 16 will be explained here.

[0102] In Figure 17, container 105 is removed from the second section 104a of the folded mailer system 101. This is indicated by the dashed double-headed arrow shown in this figure. Container 105 can be opened to allow access to its fluid contents.

[0103] Next, referring to Figure 18A, this figure is an elevation view of the mailer system 101 and shows another version / embodiment of the seventh step 2635' (see flowchart in Figure 26) that forms the mailer system 101. Figure 18A is substantially similar to Figure 13B. Therefore, only the differences between Figure 18A and Figure 13B will be described here.

[0104] In Figure 18A, a straight cut line or perforation 1015' is visible, and the third section 102a is opened along this line 1015' and folded along the folding line 1022a. Only aperture 107 is shown, but aperture 107 surrounds container 105 (not shown). Sections 202a and 202b are removed along the cut lines or perforation lines 1005 and 1020.

[0105] Next, referring to Figure 18B, this figure is an elevation view of the mailer system 101 and shows another version / embodiment of the seventh step 2635' (see flowchart in Figure 26) that forms the mailer system 101. Figure 18B is substantially similar to Figure 18A. Therefore, only the differences between Figure 18A and Figure 18B will be described here.

[0106] In Figure 18B, two sections 202a and 202b (see Figure 18A) have been removed along the cut lines or perforations 1005 and 1020. Similar to Figures 18A and 13B, the cut line or perforation 1015' is visible and is more linear compared to the cut line 1015 in Figure 13A.

[0107] Figures 19-25 illustrate how geometric planar sheets for the mailer system 101, which are later folded, are formed from one or more layers of material that are laminated together. Alternatively, as an example, Figure 19 illustrates how a single-layer sheet (unfolded) 103 for the mailer system 101 is formed from a single layer of cardboard. Alternatively, multiple layers may be combined to form a geometric planar sheet that is later folded.

[0108] As an example, two layers are shown in Figures 20 and 21, respectively. Figures 20-21 illustrate the possibility that the Mailer system 101 (i.e., the geometric planar sheet 103 before folding) may be formed from two layers of material for the geometric planar sheet 103. Thus, in Figure 20, the planar sheet 103 for the Mailer system 101 can be made from two layers: one made from cardboard and the other from plastic film. Figure 21 then shows a sheet 103 made from two layers consisting of cardboard and varnish. The exact dimensions of these layers may not be to scale, but the relative thickness of the layers roughly corresponds to these figures.

[0109] In embodiments of the multilayer structure illustrated in Figures 20-21, thin layers such as a plastic film (Figure 20) and a varnish layer (Figure 21) form the outer surfaces of the mailer system 101 (i.e., 102b, 104b, 106b - see Figure 3), while thicker layers (cardboard) form the inner surfaces of the mailer system 101 (102a, 104a, 106a - see Figure 2) after being folded. The layers may be designed to absorb any liquid that might leak from the container 105 described above.

[0110] In embodiments of the multilayer structure illustrated in Figures 22-23, thin layers such as a plastic film (Figure 22) and a varnish layer (Figure 23) form the inner sides of the mailer system 101 (102a, 104a, 106a - see Figure 2), while thicker layers (cardboard) can form the outer layers of the mailer system 101 after folding (i.e., 102b, 104b, 106b - see Figure 3). As described above, each layer may be designed to absorb any liquid that may leak from the container 105 described above.

[0111] Next, referring to Figure 24, this figure shows a cross-sectional view of a geometric planar sheet 103 consisting of three layers: cardboard, plastic film, and cardboard. Although precise dimensions are not shown in Figure 24 (or other cross-sectional figures 19-25), the ratios or relative thicknesses between the layers can be used to form the geometric planar sheet 103.

[0112] Referring next to Figure 25, this figure shows a cross-sectional view of a geometric planar sheet 103 made of three layers: a single varnish layer sandwiched between two cardboard layers. Other layers and combinations of layers suggested in Figures 20-25 are also possible and are within the scope of this disclosure.

[0113] Figure 21 shows a preferred example embodiment. In some embodiments of Figure 21 (not shown), certain areas of the mailer system 101 may not have varnish, and ink may be applied to the outer sides of the folded mailer system 101 so that mailing address information can be printed on the surface.

[0114] Next, referring to Figure 26, this figure shows a flowchart of method 2600 for forming the folded mailer system 101 corresponding to Figures 10-18B described above. Step 2605 is the first step of method 2600. In step 2605, the mailer system 101 of Figure 1-25 is formed by perforations 1005, 1015, 1020 and an aperture 107 in one of the three sections 102, 104, 106 of the tri-fold system 101.

[0115] As those skilled in the art will understand, the mailer system 101 can be formed not only by folding the sheet at any number of folds, but also without any folds. That is, system 101 can be formed as a two-fold system 101. Alternatively, system 101 can be formed as a four-fold system. Furthermore, as those skilled in the art will understand, system 101 can also function without folds (single sheet - no folds).

[0116] In step 2605, perforations 1005, 1015, and 1020 are formed within the system 101, as shown in Figure 10 above. This allows sections 202a to 202g to be removed later. As those skilled in the art will understand, any number of perforations 1005, 1015, and 1020 can be formed to enable the opening of the mailer system 101. Also in step 2605, an aperture 107 for receiving the container 105 is formed in section 106 of the tri-fold system 101. Depending on the number of folds used or not used, the step of forming the aperture 107 may be omitted in alternative exemplary embodiments within the scope of this disclosure.

[0117] Subsequently, in the second step 2610 of Figure 26, the container 105 is formed and positioned in the middle section 104 of the tri-fold system 101 so as to align with the aperture 107 of the end section 106 of the tri-fold system, as shown in Figure 11. As described above, it is recognized that the mailer system 101 may be formed with or without any number of folds as desired. Therefore, this second step 2610 may be modified and / or omitted depending on the number of folds in the mailer system 101.

[0118] Next, in the third step 2615, as shown in Figure 12, the third section 106 of the tri-fold mailer system 101 is folded along the folding line 1022b so that the aperture 107 aligns with the outer perimeter of the container 105. As mentioned above, the outer perimeter of the aperture 107 is slightly larger than the outer perimeter of the container 105 so that the aperture 107 can accommodate the entire outer perimeter of the container 105. Figure 12 shows this third step 2615 and the third section folded along the folding line 1022b so that its back side 106b is exposed and positioned above the front side 104a of the second section 104.

[0119] Subsequently, in the fourth step 2620 of Figure 26, the first section 102 of the tri-fold mailer system 101 is folded along the fold line 1022a, closing the tri-fold mailer system 101 as shown in Figures 12-13A / 13B. As described above, Figure 13A shows a first exemplary embodiment in which the cut line 1015 has a straight or linear geometric shape. On the other hand, Figure 13B shows a second exemplary embodiment in which the cut line 1015' has a curved geometric shape. This demonstrates that the cut line and / or fold line can be formed in any number of geometric shapes without departing from the present disclosure.

[0120] Next, in step 2625 of Figure 26, the tri-fold mailer system 101 can be automatically transported / mailed / processed via the USPS using Class I postage so that it becomes "machine-processable" by the USPS. This step 2625 corresponds to Figure 8, which shows that the mailer system 101 is flexible and can be bent around the drum 800 and belt 810 in the automated mailer system, as can be understood by those skilled in the art.

[0121] Sections 102, 104, 106 and container 105 of system 101 have a certain degree of flexibility so that they can be folded around drum 800 as described above. Thus, in the fifth step 2625 of this method 2600, mailer systems 101, 101' are foldable or bendable around drum 800 as shown in Figure 8 during automated sorting used by USPS and other jurisdictions / entities.

[0122] Subsequently, in the sixth step 2630, the mailer system 101 was received by a consumer located at the mailing address 1404 (see Figure 14). The consumer can also open the mailer system 101 by removing two sections 202a and 202b along the perforations 1005 and 1020, as shown in Figure 14.

[0123] Next, in the seventh step 2635, the third section 102a of the tri-fold structure is "opened" by opening the opening 102a along the curved cut line 1015 and unfolding the fold along the fold line 1022a, as shown in Figure 15. In Figure 15, the inner third section 102a and the inner second section 104a are visible. The outer first section 106b is also visible in Figure 15.

[0124] In the eighth step 2640, the third section 106a can be “opened” by unfolding the section 106a along the fold line 1022b, as illustrated in Figure 16. In Figure 16, all three tri-fold front sections 102a, 104a, and 106a are visible. The aperture 107 of the first tri-fold section 106a is positioned diametrically opposite to the container 105 located in the second tri-fold section 104a. The container 105 is ready to be removed from the mailer system 101 (and in particular the front part 104a of section 104).

[0125] Next, in the ninth step 2645, the container 105 can be removed from the second section 104a of the folded mailer system 101, as shown by the dashed double-headed arrow in Figure 17. Specifically, as described above, the container 105 can be removed from the mailer system 101 by using peelable gel glue to pull it away from the front surface 104a of section 104. The glue then typically remains on the front surface 104a of section 104. Once removed from the mailer system 101, the container 105 in Figure 17 can be opened so that its contents can be used by the consumer. Method / process 2600 can be reversed / repeated as necessary and as understood by those skilled in the art.

[0126] Referring now to Figure 27A, this figure shows a top view of a container 105' according to an alternative exemplary embodiment of the mailer system 101. As described above, the container 105' has end portions 507. The container 105 further has a bottom plate 511 to which the end portions 507 are attached. The bottom plate 511 further has edges 509. Figure 27A, as with Figure 5A, also shows various exemplary dimensions in millimeters indicated between the double-headed arrows. Other dimensions are also possible and are included in the scope of this disclosure.

[0127] Next, referring to Figure 27B, this figure shows a side view of the container shown in Figure 27A according to an alternative exemplary embodiment, and corresponds to Figure 27A. According to this exemplary embodiment in Figures 27A and 27B, the distance between the end portion 507 and the edge 509 of the bottom plate 511 is approximately 11.5 mm. Compared to the exemplary embodiment shown in Figures 5A-5B, in that embodiment, the distance between the end portion 507 and the edge 509 of the bottom plate 511 is approximately 5.5 mm.

[0128] Furthermore, certain steps of a process or process flow made possible by the mechanical drawings herein naturally precede other steps in order to function as described herein. However, the invention is not limited to the order of steps described herein if such order or permutation does not alter the functionality of the invention. That is, it is acknowledged that some steps may be performed before, after, or in parallel (substantially simultaneously) other steps without departing from the scope and spirit of the invention. In some cases, certain steps may be omitted or not performed, but this does not constitute a departure from the invention.

[0129] The materials of the components shown in some of the figures may include various types of polymers / plastics such as silicon, and compostable plant-derived resin films. Other plastics besides those described above may be used without departing from the scope of this disclosure. Furthermore, other materials other than plastics are also possible and are included within the scope of this disclosure. Other materials other than plastics include, but are not limited to, composite materials and any combination thereof.

[0130] While several embodiments have been described in detail and illustrated with several figures above, those skilled in the art will readily understand that many modifications from those described and illustrated are possible in embodiments without substantially departing from the present disclosure. Accordingly, such modifications are intended to fall within the scope of the present disclosure as defined in the appended claims.

[0131] For example, Figure 1-25 illustrates several mechanical configurations, which can be replaced / substituted by additional and / or fewer structures. Furthermore, any mechanical equivalent of any illustrated structure may be replaced by many of the structures illustrated in some figures, as will be understood by those skilled in the art. Such replacement of mechanical equivalent structures is within the scope of this disclosure.

[0132] Similarly, in the claims, the means-plus-function clause applies to the fact that the structures described herein perform the described functions, and applies not only to structural equivalents but also to equivalent structures. Therefore, nails and screws may not be structural equivalents because nails use a cylindrical surface to fasten wooden parts, while screws use a helical surface; however, in the context of fastening wooden parts, nails and screws may be equivalent structures.

[0133] It is the applicant's clear intention that Article 35, paragraph 112, paragraph 6 of the Patent Act shall not apply to any limitation of any claim in this application (or any future claim), except where the claim explicitly uses the term “means” in conjunction with the relevant function.

[0134] The following numbered clauses are also part of this disclosure and constitute the spirit and scope of the invention. 1. A mailer system, A container for holding liquids, A structure for holding a container when it is being shipped, comprising at least two sections that fold together when the container is being shipped, A mailer system comprising a container and the structure, wherein the container and the structure are machine-processable within the automated mailer system. 2. The system described in Clause 1, wherein one section of the structure has an aperture for accepting a container. 3. The system according to Clause 1 or Clause 2, wherein the structure comprises a third section that folds over the first and second sections. 4. A system described in any of Clauses 1 to 3, in which the structure includes a tri-fold configuration when the container and structure are shipped. 5. Each section has a removable part that is removed after the container and structure have been shipped, and the system is such that the container can be removed from the structure, as described in any of Clauses 1 to 4. 6. A system in which the container has a fluid outlet and which is described in any of Clauses 1 to 5. 7. A system as described in any of Clauses 1 to 6, wherein the container holds a fluid containing at least one of the following: fragrances, pheromones, cosmetics, insecticides, anthelmintics, and medicinal products for the treatment of animals or humans: 8. A container having a bottom plate, as described in any of Clauses 1 to 7. 9. A system as described in any of clauses 1 to 8, wherein the structure comprises a planar sheet. 10. A system described in any of Clauses 1 to 9, wherein the planar sheet comprises multiple layers. 11. A mailer system, A folded flat member, A container that is attached to a folded flat member and seals the medication in a dispensing form, A mailer system comprising a mailer system which is mechanically processable by an automated mailer system which bends the mailer system around a drum using at least one drum. 12. The system according to Clause 11, wherein the drug delivery form comprises a topical composition for the treatment or prevention of external parasitic infections in animals. 13. The system according to Clause 11 or Clause 12, wherein the external parasites include at least one of fleas, ticks, lice, and scabies. 14. A system described in any of Clauses 11 to 13, wherein the drug delivery form includes at least one of the following: fragrances, pheromones, cosmetics, insecticides, and pharmaceuticals. 15. A system according to any one of clauses 11 to 14, wherein the folded planar member comprises multiple layers. 16. A system as described in any of Clauses 11 to 15, wherein one layer comprises at least one of cardboard, varnish, or plastic film. 17. A mailer system, A folded flat member, A container that is attached to a folded flat member and seals the medication in a dispensing form, A mailer system comprising a folded planar member further comprising an aperture for receiving a container, wherein the mailer system is mechanically processed by an automated mailer system that bends the mailer system around a drum using at least one drum. 18. The system according to Clause 17, wherein the drug delivery form comprises a topical composition for the treatment or prevention of external parasitic infections in animals. 19. The system described in Clause 17 or Clause 18, wherein the external parasite includes at least one of fleas, ticks, lice, or scabies. 20. A system described in any of Clauses 17 to 19, wherein the drug delivery method includes at least one of the following: fragrances, pheromones, cosmetic treatments, insecticides, and pharmaceuticals.

[0135] While the selected embodiments have been illustrated and described in detail, it will be understood that various substitutions and modifications can be made without departing from the spirit and scope of the invention, as defined by the attached claims. [Explanation of Symbols]

[0136] 101 Mailer System Sections 102, 104, and 106

Claims

1. It is a mailer system, A container for holding liquids, A structure for holding the container when the container is being shipped, comprising a structure having a first section and a second section that fold toward each other when the container is being shipped, The container and the structure are machine-processable within the automated mailer system. The liquid comprises a mailer system for the treatment or prevention of external parasitic infections in animals.

2. The system according to claim 1, wherein one section of the structure has an aperture for receiving the container.

3. The system according to claim 1, wherein the structure comprises a third section that folds over the first section and the second section.

4. The system according to claim 3, wherein the structure includes a tri-fold configuration when the container and the structure are shipped.

5. The system according to claim 1, wherein each section has a removable part that is removed after the container and structure have been shipped, so that the container can be removed from the structure.

6. The system according to claim 1, wherein the container has a fluid outlet.

7. The system according to claim 1, wherein the container has a bottom plate.

8. The system according to claim 1, wherein the structure comprises a planar sheet.

9. The system according to claim 8, wherein the planar sheet comprises a plurality of layers.

10. It is a mailer system, A folded flat member, A container attached to the aforementioned folded flat member, which seals the medication in a dispensing form, A mailer system comprising, wherein the mailer system is mechanically processable by an automatic mailer system that bends the mailer system around the drum using at least one drum, and the drug delivery form comprises a topical composition for the treatment or prevention of external parasitic infections in animals.

11. The system according to claim 10, wherein the external parasite includes at least one of fleas, ticks, lice, and scabies.

12. The system according to claim 10, wherein the folded planar member includes a plurality of layers.

13. The system according to claim 12, wherein one layer comprises at least one of cardboard, varnish, and plastic film.

14. It is a mailer system, A folded flat member, The system includes a container attached to the aforementioned folded planar member for sealing the medication in a dispensing form, The folded planar member further comprises an aperture for receiving the container, the mailer system is mechanically operable by an automated mailer system that uses at least one drum to bend the mailer system around the drum, and the drug delivery form comprises a topical composition for the treatment or prevention of external parasitic infections in animals.

15. The system according to claim 14, wherein the external parasite includes at least one of fleas, ticks, lice, and scabies.

16. The system according to claim 14, wherein the drug delivery method includes at least one of fragrances, pheromones, cosmetic treatments, insecticides, and pharmaceuticals.

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