Fibroin microspheres and method for manufacturing the same

JP7863332B2Active Publication Date: 2026-05-21UNIV OF TSUKUBA
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
UNIV OF TSUKUBA
Filing Date
2021-12-21
Publication Date
2026-05-21

AI Technical Summary

Technical Problem

Existing methods for producing microspheres from natural polymers, particularly silk fibroin, result in non-uniform sizes and irregular shapes, which hinder their application in cosmetics and other fields, and there is a lack of methods for producing microspheres from 100% natural materials to reduce environmental impact.

Method used

The production of fibroin microspheres is achieved through a reverse miniemulsion method followed by recrystallization in alcohols with 3 or more carbon atoms, such as isopropanol or n-butanol, resulting in microspheres with uniform particle size, smooth surfaces, and a spherical shape.

Benefits of technology

The method produces fibroin microspheres with a micrometer-scale size, smooth surface, and uniform shape, suitable for use in cosmetics and other applications, while being biodegradable and environmentally friendly.

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Abstract

The present invention provides a method for producing natural polymer micro-spheres, the method comprising: a step for adding an organic solvent having a surfactant dissolved therein to a solution (e.g., fibroin aqueous solution) containing a natural polymer, and homogenizing the obtained mixture to generate a natural polymer colloidal suspension; and a step for adding the natural polymer colloidal suspension to an alcohol having 3 or more carbon atoms to form natural polymer micro-spheres.
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