Anti-human PD-1 agonist antibodies for treating or preventing inflammatory diseases and pharmaceutical compositions containing the same

Anti-human PD-1 agonist antibodies targeting specific binding domains and enhancing Fc receptor affinity provide a therapeutic approach to treat inflammatory diseases by stimulating immunosuppressive mechanisms, effectively reducing inflammation and immune response.

JP7870453B2Active Publication Date: 2026-06-05FOUND FOR BIOMEDICAL RES & INNOVATION +2
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Patent Information

Authority / Receiving Office
JP · JP
Patent Type
Patents
Current Assignee / Owner
FOUND FOR BIOMEDICAL RES & INNOVATION
Filing Date
2022-05-12
Publication Date
2026-06-05

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Abstract

The present invention pertains to a search for conditions necessary for an antibody against human PD-1 to possess an agonist activity, establishing of an agonist antibody optimized on the basis of such necessary conditions, and application of said agonist antibody as a drug for human inflammatory diseases. An agonist antibody against human PD-1 or a functional fragment thereof according to the present invention is characterized in that the antibody or the functional fragment thereof binds to domain #7, of human PD-1, represented by SEQ ID: 9.
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