Intracellular delivery of therapeutic proteins designed to invade and autonomously dissolve, and methods for their use

Abstract

A bacterial delivery platform utilizing a mechanism unique to Salmonella to deliver protein-based drugs into cells is provided herein.

Description

Technology Field

[0001] Government support

[0002] This invention was made with government support pursuant to Grant R43 CA233136 awarded by the National Institutes of Health. The government holds certain rights in this invention.

[0003] priority

[0004] This application claims the benefit of priority of U.S. Provisional Patent Application No. 63 / 147,506 filed on February 9, 2021, the benefit of said priority is claimed herein, the whole of which is incorporated herein by reference. Background Technology

[0005] Cancer is generally characterized by the uncontrolled and invasive growth of cells. These cells can spread to other parts of the body (metastasis). Conventional anticancer treatment, consisting of surgical resection, radiation therapy, and chemotherapy, may be effective for some cancers / patients; however, it is not effective for many cancer patients. Therefore, additional medical treatment is required.

[0006] The role of bacteria as anticancer agents has been recognized for over 100 years, and Clostridium (Clostridium) , Bifidus (Bifidus), and Salmonella (Salmonella) Many bacterial genera, including [specific species], have been shown to preferentially accumulate in tumor tissue, causing degeneration.

[0007] Rat typhoid bacteria for treating solid tumors (Salmonella Typhimurium)The use of [the virus] began with the development of the non-pathogenic strain VNP20009. This strain, which is well tolerated in mice and humans, has been shown to preferentially accumulate (>2000-fold) in tumors across the liver, spleen, lungs, heart, and skin, delaying tumor growth by 38–79% and extending the survival of mice with tumors. In early clinical trials, *Rotavirus* was found to be resistant at high doses and capable of effectively colonizing human tumors.

[0008] Engineered non-pathogenic Salmonella selectively colonize 1,000 times more tumors than any other organ, invade cancer cells, and deliver therapeutic agents intracellularly, creating an ideal bacterial delivery vehicle for cancer treatment. In this study, the regulation of flhDC activity and subsequent flagellar expression in engineered Salmonella is in vivo ( in vivo ) and in vitro ( in vitroIt is demonstrated that this selectively enables intracellular protein delivery in tumor cells. The expression of flhDC / flagellates is regulated to enable both tumor colonization and invasion into cancer cells for the purpose of intracellular protein and therapeutic delivery. Flagella are required for cellular invasion into cancer cells in vitro and in vivo. However, in the bloodstream and / or systemic circulation, flagella expression in Salmonella leads to rapid clearance and significantly reduces tumor colonization. Consequently, an inducible version of flhDC was genetically engineered into an engineered strain of Salmonella lacking the intrinsic version of the transcription factor (alternatively, the endogenous promoter could be replaced with an inducible promoter). The inducible system allowed for strict control of flhDC expression within the therapeutic strain. Salmonella lacks the ability to express flhDC-colonized tumors, which is due to greater selectivity than the parental control strain. In the intratumoral environment, when 'remote control' was administered to an arabinose-inducible system along with arabinose to induce flhDC expression, the engineered Salmonella were able to invade the cells and deliver the protein into the tumor cells.

[0009] A method is described for controlling flagella expression through external means (e.g., small molecule inducible gene circuits or inducible expression systems) so that Salmonella containing; and engineered strains of Salmonella do not systemically express flagellin. After the bacteria colonize the tumor to an optimal level, a 'remote control' / inducible strategy is used to induce the expression of flagella and the type 3 secretory system by activating the expression of a recombinant and / or inducible version of flhDC, a motility regulator, with a small molecule.

[0010] Another embodiment enables the deletion of the SseJ gene in Salmonella transfer strains. This gene restricts the location of Salmonella to Salmonella-containing vacuoles (SCVs), thereby increasing the transfer potential of the strain. This can be achieved in combination with the previously described transfer control or without transfer control.

[0011] One embodiment provides a bacterial cell, said bacterial cell comprising: a) inducible expression of flagella; and b) a lysate gene or lysate cassette operably linked to a Salmonella promoter induced into the cell. In one embodiment, the bacterial cell is a bacterial cell within a tumor. In another embodiment, the bacterial cell is a Clostridium, Bifidobacterium, E. coli, or Salmonella cell. In one embodiment, the bacterial cell is a Salmonella cell. In one embodiment, the lysate cassette is Lysin E from phage phiX174, a lysate cassette of phage iEPS5, or a lysate cassette from lambda phage. In another aspect, the intracellularly induced Salmonella promoter is a promoter for one of the genes of the Salmonella pathogenic islet type III secretion system (SPI2-T3SS) selected from SpiC / SsaB, SseF, SseG, SseI, SseJ, SseK1, SseK2, SifA, SifB, PipB, PipB2, SopD2, GogB, SseL, SteC, SspH1, SspH2, or SirP group.

[0012] In one embodiment, the cell does not contain endogenous flhDC expression. In another embodiment, the cell contains an exogenous inducible promoter operably linked to an endogenous or exogenous flhDC gene. In another embodiment, the exogenous inducible promoter is operably linked to an endogenous flhDC gene. In another embodiment, the exogenous inducible promoter is operably linked to an exogenous flhDC gene. In an embodiment, the exogenous inducible promoter comprises the arabinose inducible promoter PBAD (L-arabinose), LacI (IPTG), salR, or nahR (acetylsalicylic acid (ASA)).

[0013] In one embodiment, bacterial cells contained SseJ deletion or SseJ expression was reduced.

[0014] One embodiment provides a cell containing a plasmid expressing a peptide. In one embodiment, the peptide is a therapeutic peptide such as NIPP1 or activated caspase 3.

[0015] One embodiment provides a composition comprising the cell population and pharmaceutically acceptable carrier described herein.

[0016] Another embodiment provides a method for selectively colonizing cancer cells, such as tumors and / or tumor-associated cells, said method comprising the step of administering a population of bacterial cells described herein to a subject in need thereof. In one embodiment, the tumor-associated cells are tumor cells or immune cells within the tumor, cancer cells or stromal cells within the tumor. Another embodiment provides a method for treating cancer comprising the step of administering an effective amount of a population of bacterial cells described herein to a subject in need thereof so as to cure cancer. Additional embodiments provide a method for inhibiting the growth / proliferation of a tumor or reducing the volume / size of a tumor, said method comprising the step of administering an effective amount of a population of bacterial cells described herein to a subject in need thereof so as to inhibit tumor growth or reduce the volume of the tumor. Another embodiment provides a method for treating metastasis, reducing its formation / number, or inhibiting the spread of metastasis, said method comprising the step of administering an effective amount of a population of bacterial cells described herein to a subject in need thereof so as to treat metastasis, reduce the formation / number of metastasis, or inhibit the spread of metastasis. In one embodiment, the tumor, tumor-associated cell, cancer, or metastasis is a lung, liver, kidney, breast, prostate, pancreas, colon, head and neck, ovary, and / or gastrointestinal tumor, tumor-associated cell, cancer, or metastasis. In one embodiment, a bacterial cell delivers a therapeutic peptide to the said tumor, tumor-associated cell, cancer, or metastasis. In one embodiment, the peptide is NIPP1 or activated caspase 3. In one embodiment, the cell does not express endogenous flhDC. In another embodiment, the expression of flhDC in the bacterial cell is regulated by an inducible promoter, wherein the bacterial cell contains an exogenous inducible promoter regulating the expression of endogenous flhDC, or the bacterial cell contains an exogenous inducible promoter operably linked to an exogenous flhDC gene.In one embodiment, the expression of flhDC is caused by colonization of the tumor, tumor-associated cell, cancer, or metastasis by the bacteria (e.g., 1x10). 6 Up to 1x10 10 It is induced after CFU / g tumor) is formed.

[0017] One embodiment provides a bacterial cell comprising: a) SseJ deletion or reduced expression of SseJ; and b) a lysate gene or lysate cassette operably linked to a Salmonella promoter induced into the cell. In one embodiment, the bacterial cell is a bacterial cell within a tumor. In another embodiment, the bacterial cell is a Clostridium, Bifidobacterium, or Salmonella cell. In an embodiment, the bacterial cell is a Salmonella cell. In one embodiment, the lysate cassette is Lysin E from phage phiX174, a lysate cassette of phage iEPS5, or a lysate cassette from lambda phage. In another embodiment, induced into the cell fat The Monella promoter is a promoter for one of the genes within the secretory system of Salmonella pathogenic islets 2 type III selected from the group of SpiC / SsaB, SseF, SseG, SseI, SseJ, SseK1, SseK2, SifA, SifB, PipB2, SopD2SspH1, SspH2, SipBp2, and SspP2.

[0018] In one embodiment, in any one of claims 28 to 33, the cell does not contain endogenous flhDC expression. In another embodiment, the cell comprises an exogenous inducible promoter operably linked to an endogenous or exogenous flhDC gene. In another embodiment, the exogenous inducible promoter is operably linked to an endogenous flhDC gene. In another embodiment, the exogenous inducible promoter is operably linked to an exogenous flhDC gene. In an embodiment, the exogenous inducible promoter comprises the arabinose inducible promoter PBAD (L-arabinose), LacI (IPTG), nahR (acetylsalicylic acid (ASA)), or salR acetylsalicylic acid (ASA).

[0019] In one embodiment, the bacterial cell contains a plasmid expressing a peptide. In one embodiment, the peptide is a therapeutic peptide such as NIPP1 or activated caspase 3.

[0020] One embodiment provides a composition comprising a cell population and a pharmaceutically acceptable carrier as described herein.

[0021] One embodiment provides a method for colonizing tumor and / or tumor-associated cells, comprising the step of administering a population of bacterial cells described herein to a subject in need thereof. In one embodiment, the tumor-associated cells are tumor cells, immune cells within the tumor, or stromal cells within the tumor. In one embodiment, a method for treating cancer is provided, said method comprising the step of administering an effective amount of a population of bacterial cells described herein to a subject in need thereof to treat cancer. Another embodiment provides a method for inhibiting the growth / proliferation of a tumor or reducing the volume / size of a tumor, said method comprising the step of administering an effective amount of a population of bacterial cells described herein to a subject in need thereof so as to inhibit tumor growth or reduce the volume of the tumor. Additional embodiments are a method for treating metastasis, reducing its formation / number, or inhibiting the spread of metastasis, said method comprising the step of administering an effective amount of a population of bacterial cells described herein to a subject in need thereof so as to treat metastasis, reduce its formation / number, or inhibit the spread of metastasis. In one embodiment, the tumor, tumor-associated cell, cancer, or metastasis is a lung, liver, kidney, breast, prostate, pancreas, colon, head and neck, ovary, and / or gastrointestinal tumor, tumor-associated cell, cancer, or metastasis. In another embodiment, a bacterial cell delivers a therapeutic peptide, such as NIPP1 or activated caspase 3, to the tumor, tumor-associated cell, cancer, or metastasis. In one embodiment, endogenous expression of flhDC is under the control of an exogenous inducible promoter. In another embodiment, expression of flhDC is regulated by an inducible promoter, and the bacterial cell contains an exogenous inducible promoter operably linked to an exogenous flhDC gene. In another embodiment, expression of flhDC is induced after the tumor, tumor-associated cell, cancer, or metastasis is colonized by the bacteria.

[0022] One embodiment provides: a) a bacterial cell comprising constitutive or inducible expression of a therapeutic peptide, wherein the therapeutic peptide is an activated caspase-3, and the activated caspase-3 is expressed as an activated protein without further processing; and b) a lysate gene or lysate cassette operably linked to a Salmonella promoter induced into the cell. In one embodiment, the bacterial cell is a bacterial cell within a tumor. In one embodiment, the bacterial cell is a Clostridium, Bifidobacterium, or Salmonella cell. In another embodiment, the bacterial cell is a Salmonella cell. In one embodiment, the lysate cassette is Lysin E from phage phiX174, a lysate cassette of phage iEPS5, or a lysate cassette from lambda phage. In one embodiment, the intracellularly induced Salmonella promoter is a promoter for one of the genes in the Salmonella pathogenic islet type III secretion system (SPI2-T3SS) selected from the group of SpiC / SsaB, SseF, SseG, SseI, SseJ, SseK1, SseK2, SifA, SifB, PipB, PipB2, SopD2, GogB, SseL, SteC, SspH1, SspH2, or SirP.

[0023] In another embodiment, the bacterial cell does not contain endogenous flhDC expression. In one embodiment, the bacterial cell contains an exogenous inducible promoter operably linked to an endogenous or exogenous flhDC gene. In another embodiment, the exogenous inducible promoter is operably linked to an endogenous flhDC gene. In another embodiment, the exogenous inducible promoter is operably linked to an exogenous flhDC gene. In an embodiment, the exogenous inducible promoter includes the arabinose inducible promoter PBAD (L-arabinose), LacI (IPTG), nahR (acetylsalicylic acid (ASA)), or salR acetylsalicylic acid (ASA).

[0024] In this embodiment, the bacterial cells contained SseJ deletion or SseJ expression was reduced.

[0025] One embodiment provides a cell expressing at least one additional exogenous therapeutic peptide, such as NIPP1.

[0026] Another aspect provides a composition comprising the cell population and pharmaceutically acceptable carrier described herein.

[0027] One embodiment provides a method for colonizing tumor and / or tumor-associated cells, comprising the step of administering a population of bacterial cells described herein to a subject in need thereof. In one embodiment, the tumor-associated cells are tumor cells, immune cells within the tumor, or stromal cells within the tumor. One embodiment provides a method for treating cancer, said method comprising the step of administering an effective amount of a population of bacterial cells described herein to a subject in need thereof to treat cancer. In one embodiment, a method for inhibiting the growth / proliferation of a tumor or reducing the volume / size of a tumor is provided, said method comprising the step of administering an effective amount of a population of bacterial cells of any one of the claims described herein to a subject in need thereof so as to inhibit the growth of the tumor or reduce the volume of the tumor. Another embodiment provides a method for treating metastasis, reducing the formation / number of metastases, or inhibiting the spread of metastasis, said method comprising the step of administering an effective amount of a population of bacterial cells described herein to a subject in need thereof so as to treat the metastasis, reduce the formation / number of metastases, or inhibit the spread of metastasis. In one embodiment, the tumor, tumor-associated cell, cancer, or metastasis is a lung, liver, kidney, breast, prostate, pancreas, colon, head and neck, ovary, and / or gastrointestinal tumor, tumor-associated cell, cancer, or metastasis. In one embodiment, a bacterial cell delivers the caspase to the tumor, tumor-associated cell, cancer, or metastasis. In another embodiment, the bacterial cell delivers at least one additional exogenous therapeutic peptide, such as NIPP1. In an embodiment, endogenous expression of flhDC is regulated by an exogenous inducible promoter. In another embodiment, expression of flhDC is regulated by an inducible promoter, and the bacterial cell contains an exogenous inducible promoter operably linked to the exogenous flhDC gene. In one embodiment, the bacterial cell does not express endogenous flhDC.In one embodiment, the expression of flhDC is induced after the tumor, tumor-associated cell, cancer, or metastasis is colonized by the bacteria. Brief explanation of the drawing

[0028] Novel features of the present invention are specifically set forth in the appended claims. A better understanding of the features and advantages of the present invention will be obtained by referring to the following detailed description describing exemplary embodiments in which the principles of the present invention are utilized and the accompanying drawings: Figures 1A–G: The intracellular lifestyle of Salmonella is regulated by flhDCs. Figure 1A) The design objective was to genetically engineer a bacterial vehicle that (1) synthesizes (produces) a protein drug (yellow / purple), (2) actively invades cancer cells, and (3) releases the drug. Over time, the drug escapes from the Salmonella vacuole (SCV, red). Figure 1B) Salmonella (light blue, arrow) invades cancer cells (red). Figure 1C) 70% of Salmonella (red; white arrow) were intracellular (co-localized red and green; black arrow) within the in vivo tumor (***, P < 0.001). Figure 1D) In ​​mouse tumors, Salmonella invaded multiple cell types, including immune, carcinoma (epithelial), and other related (stromal) cells. E) In monolayer cancer cells in Fig. 1, re-expression of flhDC (flhDC+) increased invasion (black arrow) compared to the non-expressing control (flhDC-; ***, P < 0.001). F) In a 3D tumor-on-a-chip with green intracellular reporters in Fig. 1, flhDC+ Salmonella invaded more than the flhDC-control (**, P < 0.01). g) After administration to mice with tumors, re-expression of flhDC increased invasion into cancerous and immune cells (*, P < 0.05). Figs. 2A–J. Design of ID Salmonella for intracellular protein release. Fig. 2A) Salmonella carrying PsifA-GFP or PsseJ-GFP reporter constructs express GFP after invasion (white arrow). Extracellular expression from PsseJ-GFP (black arrow) was lower than that of PsifA-GFP (***, P < 0.001). Intracellular activity of the PsseJ promoter was four times higher than extracellular activity (***, P < 0.001). Fig. 2B) Induction of PBAD-LysE at 96 hours (arrow) followed by 0.39 hours -1 Induces bacterial lysis at the rate of. Fig. 2C) When administered to MCF7 cancer cells, 68% of intracellular Salmonella lysed with PsseJ-lysE were significantly higher than in the PsseJ-GFP control group (***, P < 0.001). Fig. 2C) Salmonella with PsseJ-lysE and Plac-GFP delivered GFP into the cell cytoplasm. Only the released GFP was stained, and intrabacterial GFP was not stained. Fig. 2E) Intracellular ID Salmonella at 0.33 hours -1It was lysed at a rate of (half-life = 2.1 hours). Fig. 2F) In liquid cultures, PBAD-lysE and PsseJ-lysE Salmonella grew at a rate similar to that of the non-transformed control (white bars). In the case of intracellular lysis, PsseJ-lysE Salmonella lysed at a rate similar to that of PBAD-lysE Salmonella induced in culture (black bars). Fig. 2G) Bacterial EGFP production per colony-forming unit (CFU). H) After invasion and before lysis, Salmonella (light blue, white arrows) were introduced into LAMP1-stained SCVs (red, yellow arrows). After lysis, GFP (green, black arrows) remained within the membrane of the SCVs. From 6 to 24 hours after invasion, the percentage of GFP released from the cytosol rather than the SCVs increased from 25% to 75% (***, P < 0.001). Fig. 2I) In phalloidin-stained cancer cells (red), released GFP (green, black arrows) migrated from the SCV near the nucleus (blue) throughout the cytoplasm. Fig. 2J) ID Salmonella (left) lysis and GFP diffuse through the cytosol of cancer cells (right). Temporal profile of GFP intensity centered on lysed bacteria. Figures 3A–G. PsseJ and flhDC are components of ID Salmonella delivery to tumors. Figure 3A) Most of the released GFP (green, black arrow) originated from lysed Salmonella (red, yellow arrow) in LAMP1-stained SCVs. Cytosomal bacteria (light blue, white arrow) were not lysed (***, P<0.001) or did not release GFP. Only the released GFP was stained. Figure 3B) Cytoplasmic ΔsifA remained intact (red, white arrow) and were less lysed than vacuolar ΔsseJ and ID Salmonella (green, black arrow) (***< P<0.001). Figure 3C) GFP (green, arrow) was delivered only when Salmonella was transformed into both PBAD-flhDC and PsseJ-LysE (***, P < 0.001). Fig. 3D) After injecting 2×10⁶ bacteria / mouse into BALB / c mice with 4T1 tumors, ID Salmonella delivered GFP to cancer cells (arrows). Fig. 3E) The delivered GFP was present in extracts from the tumor (T) but not in the liver (L) or spleen (S). F) When ID Salmonella was administered to BALB / c mice with 4T1 tumors along with induced PBAD-flhDC, GFP (arrows) was delivered to more cells than in the flhDC-control group (***, P < 0.001). g) Luciferase-expressing ID Salmonella was intravenously injected into BALB / c mice with 4T1 tumors, and bacterial density within the tumor was measured for 14 days using bioluminescence imaging. Figures 4A–E. Efficacy of ID Salmonella. Figure 4A) Anti-actin nanobodies (NB) and GFP (Ctr) were delivered to 4T1 cancer cells using ID Salmonella. Beta-actin was immunoprecipitated with the delivered nanobodies and concentrated 2.5-fold compared to the control group. Figure 4B) Salmonella delivery of ID NIPP1-CD and CT Casp-3 caused more cell death (red, white arrows) in Hepa 1-6 cells compared to the control group (***, P < 0.001, top). Invaded or non-invaded cells (yellow arrows) were not killed by the control Salmonella (green, black arrows). Figure 4C) Delivery of NIPP1-CD and CT Casp-3 caused cell death (red) in microfluidic tumor masses (*, P < 0.05; **, P < 0.01). As Salmonella invaded the cells and delivered proteins (*, P < 0.05), mortality increased over time. Figure 4 D) Delivery of CT Casp-3 reduced the growth of 4T1 mammary tumors compared to the bacterial control group delivered GFP (*, P < 0.05; n = 3). E) On day 19 after injection, the volume of Hepa 1-6 liver tumors treated with CT-Casp-3 was 12% of that of the control group (***, P < 0.001; n = 3; left). As a result of treatment with CT Casp-3, the tumor growth rate decreased compared to the Salmonella control group (P < 0.05, middle), survival rate significantly increased (P < 0.05, right), and one mouse was cured. Figures 5A–D. Tumor selectivity of ΔflhD and ΔsifA Salmonella. Figure 5A) Tumor colonization of ΔflhD Salmonella did not change compared to the parental control group. However, liver colonization of ΔflhD Salmonella was less than 10 times that of the control group (*, P<0.05). Figure 5B) Although not statistically significant, the colonization levels of all three flhDC-overexpressing tumors were lower than those of the parental control group (P=0.34). Fig. 5C) Aplagelate and flhDC expressing ΔfliGHI Salmonella colonized the liver more than 8-fold and 12-fold higher than the ΔflhD and ΔfliGHI +ΔflhD strains, respectively (*, P<0.05). Fig. 5D) There was no difference in tumor colonization levels among ΔfliGHI, ΔflhD, and ΔfliGHI +ΔflhD Salmonella. Figures 6A–I. flhDC activity is required to increase the bacterial dispersion in tumors. Figure 6A) Mice with 4T1 tumors were injected with ΔflhD Salmonella. FlhDC expression was induced by administering arabinose to half of the mice at 48 hours after bacterial injection, and at 48 and 72 hours after bacterial injection. Figure 6B) Salmonella not induced with flhDC were non-motile and formed distinctly separated colonies in necrotic (yellow arrows) or viable tissue (green arrows). Figure 6C) 75% of the distinct colonies resided in necrotic tissue, while only 25% of the colonies were located in viable tumor tissue (**, P<0.01). Fig. 6D) The bacterial growth rate in necrosis (0.12 hr-1) was slightly higher than in viable tumor tissue (0.11 hr-1) (*, P<0.05), corresponding to a doubling time of 6.5 hours in viable tumor tissue versus 6 hours in necrosis (Fig. 6E) (*, P<0.05). Fig. 6F) The size of dense bacterial colonies (red border) was visibly larger in induced flhDC compared to uninduced tumors. The scale bar is µm. Fig. 6G) The size of dense colonies was 50% larger within flhDC-induced tumors compared to uninduced tumors (*, P<0.05). h) The abundance of satellite colonies (green arrows) outside the major dense bacterial colonies was visually larger in tumors containing induced flhDC compared to uninduced Salmonella. The scale bar is 200 µm. I) In contrast to uninduced Salmonella, twice as many isolated satellite colonies were present in tumors containing induced flhDC (*, P<0.05). Figures 7A–I. flhDC activity increases the dispersion of intracellular Salmonella in in vitro and in vivo tumors. Figure 7A) Microfluidic tumor-on-a-chip was infected with flhDC-induced or uninduced IR Salmonella. These bacteria selectively expressed GFP intracellularly. Figure 7B) flhDC-induced Salmonella (green) was distributed throughout the tumor mass, whereas uninduced bacteria were faintly detected toward the anterior edge of the tumor mass (white arrow). The scale bar is 100 µm. Figure 7C) In contrast to uninduced Salmonella, the amount of intracellular bacteria in flhDC-induced tumors was 50 to 75 times greater for x > 5 (**, P<0.01; ***, P<0.001). Fig. 7D) The amount of intracellular bacteria induced by flhDC continued to increase over time compared to the uninduced control group (*, P<0.05; **, P<0.01; ***, P<0.001). Fig. 7E) Mice were infected with IR Salmonella, and flhDC was expressed in one group by administering arabinose. Fig. 7F) Dense uninduced Salmonella contained significantly fewer intracellular bacteria (yellow arrows) compared to induced colonies (yellow border). Fig. 7G) The fraction of intracellular flhDC-induced Salmonella was three times larger than that of uninduced colonies within the tumor (*, P<0.05). h) The dispersion of intracellular bacteria in the tumor was greater after flhDC induction. Euclidean distance mapping of intracellular bacteria showed that tumor coverage was 50% greater when flhDC was expressed (Figure 7, I) (*, P<0.05). Figures 8A–B. flhDC expression was required for intracellular protein delivery into cells widely distributed within the tumor in vivo. Figure 8A) When flhDC was induced, intracellular delivery occurred in cells (white arrows) that were spatially more distributed within the tumor. Euclidean distance mapping demonstrated that tumors treated with Salmonella induced by flhDC possessed cells carrying GFP, which were 60% more spatially distributed within the tumor compared to the uninduced control group (Figure 8B) (*, P<0.05). Figures 9A–D. Engineered Salmonella is more effective for intracellular delivery than cytosolic Salmonella. Figure 9A) Tumors colonized by ΔsifA Salmonella were 10 times smaller than those of the parental control strain (*, P<0.05). Figure 9B) Tumors colonized by ΔsifA Salmonella colonized 15 times fewer livers than those of the parental control strain (*, P<0.05). Figure 9C) Cytosolic ΔsifA Salmonella remained almost entirely intact (red) within cancer cells, whereas most of FID Sal was lysed within cancer cells (green dots FID Sal panel). Figure 9D) FID Salmonella was lysed at least 18 times more than ΔsifA Salmonella at any given time point (***, P<0.001). Figures 10 A–J. flhDC activity is reduced by enabling the escape of Salmonella from vacuoles. Figure 10 A) Monolayer 4T1 cells were infected with ID Sal or FID Sal. Figure 10 B) For cells treated with FID Sal (green and red dots), total bacterial invasion was greater; however, compared to ID Sal, bacterial lysis (green) was reduced, and more FID Sal remained intact (red) after cancer cell infection. Figure 10 D) 60% of the control ID Sal was lysed, whereas only 40% of the FID Sal was lysed (**, P<0.01). E) 4T1 cells were infected with the control or flhDCs expressing Salmonella. Figure 10 F) The control Salmonella were mainly in the vacuoles (red circles). However, a larger number of flhDC-induced Salmonella were in the cytosol (white circles). Figure 10 G) 90% of the control Salmonella resided within the vacuoles inside cancer cells, compared to 70% of the flhDC-induced bacteria (**, P<0.01). H) ID Sal was more likely to be lysed within the cell because the bacteria remained in the vacuoles (white arrow). Figure 10 I) A significant portion of FID Sal was lysed within the cell (white arrow), but a small but significant proportion of the bacteria's intracellular vacuoles were destroyed and remained unlysed (cyan arrow). Figure 10 J) The presence of a significant amount of unlysed cytosol and FID Sal was observed in vivo (white arrow). Figures 11 A–D. Overexpression of flhDC in Salmonella with impaired vacuolar escape ability maintains high cell invasion and restores lysis efficiency. Figure 11 A) Invasion of 4T1 cells infected with ID Sal was low, but they were lysed with high efficiency intracellularly (green dots). More FID Sal invaded 4T1 cancer cells, but the lysis efficiency was lower (green dots). ΔsseJ FID Sal invaded 4T1 cancer cells and was lysed with high efficiency intracellularly (red and green dots). Figure 11 B) ΔsseJ FID Sal invaded 3 times more cancer cells than the ID Sal control group (**, P<0.01). Figure 11 C) ΔsseJ FID Sal, which was lysed with 20% greater efficiency than ID Sal, and (Figure 11 D) delivered 2.5 times and 2 times more protein intracellularly than ID Sal or FID Sal, respectively (**, P<0.01). Fig. 12. Regulating flhDC expression increases the tumor selectivity and intracellular delivery distribution of engineered Salmonella. Salmonella lacking flhDC expression colonized tumors more selectively than strains without regulated flhDC expression. In tumors, flhDC expression enabled Salmonella to disperse and invade tumor cells. Expressing flhDC in engineered ΔsseJ strains enables Salmonella to maintain vacuoles and induces higher lysis efficiency and overall protein delivery within tumor cells. Figures 13A–B. Genomic integration of inducible flhDCs invades not only cancer cells but also parental and plasmid-based inducible flhDC systems. A) After arabinose induction of episomal and chromosomal-integrated flhDC systems, Salmonella invaded parental strains as well as cancer cells (red) equally (green dots). B) Uninduced knock-in strains were as non-invasive as uninduced plasmid-based systems. After induction, EBV-002 with chromosomal-integrated flhDC gene circuits was more invasive than uninduced plasmid-based or genome-knock-in strains (*, P<0.05). Figures 14A–B. Modulation of flhD expression in EBV-002 with salicylic acid. Figure 14A) EBV-002 was transformed with salicylic acid-induced flhD constructs. The flhD gene was tagged at the C-terminus with low, medium, or high-activity degradation tags to inhibit flhD activity in the uninduced state. As expected, none of the three strains invaded cancer cells without salicylic acid induction. However, after induction, only EBV-002 transformed with flhD containing low or medium-activity degradation tags invaded multiple cells (green dots). EBV-002 containing flhD with high-activity degradation tags was only weakly invasive after induction. Figure 14B) PBAD induction by flhD doubled only the intracellular invasion of EBV-002 compared to the uninduced control group. EBV-002 invaded a significant number of cells without a degradation tag to inhibit flhD activity in the uninduced state. However, salicylic acid-induced samples (2) and (3) invaded about 30 times more cells than the uninduced control. EBV-002 containing a highly active degradation tag on flhD (sample 4) invaded 5 times more cancer cells than the uninduced control. Induction in samples (2), (3) and (4) was all statistically significant at P<0.01. Figures 15A–D. Clinical EBV-002 swims and invades cancer cells triggered by aspirin. EBV-002 with a genomic deletion of flhD was genetically engineered to express flhDC via a salicylic acid-responsive gene circuit. Figure 15A) Without salicylic acid, the bacteria remained non-motile. After inducing the bacteria with salicylic acid, all bacteria were highly motile, as indicated by the bacterial pathways (uninduced, blue; induced, red). Figure 15B) Salicylic acid-induced EBV-002 was 12.7 times more motile than uninduced bacteria (***, P<0.001). Figure 15C) Aspirin induction of flhDC potently regulated EBV-002 invasion of cancer cells. Aspirin-induced EBV-002 (green) invaded almost all cancer cells (white arrows). Fig. 15 D) Aspirin-induced EBV-002 invaded cancer cells 30 times more than non-induced EBV-002 (***, P<0.001). Figures 16A–B. Determination of the minimum amount of salicylic acid required to induce EBV-002 cell invasion. Figure 16A) Salicylic acid concentrations exceeding 500 nM induced microscopically visible intracellular EBV-002. Figure 16B) A minimum of 500 nM of salicylic acid was sufficient to induce high levels of cell invasion (**, P<0.01). Figures 17A–B. Biodistribution and protein delivery of EBV-003 and EBV-001. A) Colonization of EBV-003 remained unchanged in the liver and spleen compared to EBV-001, whereas the colonized tumors of the EBV-003 strain were 10.7 times higher than those of the first-generation strain (**, P<0.01). B) EBV-003 delivered 31 times more protein into the tumor compared to EBV-001. Neither EBV-001 nor EBV-003 delivered detectable amounts of protein to the liver or spleen. Figures 18 A–C. Induction of flhD with salicylates increases the infiltration and intracellular invasion of EBV-003 within viable tumor tissue. Figure 18 A) Tumors containing uninduced (left) and induced (right) EBV-003. More bacteria (red X) were present intracellularly within or immediately adjacent to the induced tumor cells compared to the uninduced sample (solid red outline). Figure 18 B) In close histological examination, uninduced EBV-003 present in close proximity to actively dividing tumor tissue did not infiltrate into the tissue, whereas the induction of flhD in EBV-003 significantly increased the presence of intracellular bacteria in actively dividing tumor cells (white arrow). C) Compared to the uninduced sample, there was a 3-fold enrichment of EBV-003-invaded cancer cells in flhD-induced EBV-003 bacteria (*, P<0.05). Figures 19A–B. Intracellular protein delivery of EBV-003 within a breast tumor. Figure 19A) Induced EBV-003 delivered proteins intracellularly into cells within the active dividing region (white arrow) of the tumor. Figure 19B) Intracellular protein delivery was detected in only 1 out of 4 mice administered with uninduced EBV-003. However, protein delivery was detected in 5 out of 6 mice treated with salicylate-induced EBV-003. Figures 20 A–C. Colonization selectivity of EBV-003 in liver metastases of breast cancer compared to healthy liver tissue. Figure 20 A) Except for small metastatic lesions, healthy liver tissue (left) contained a very limited number of EBV-003 colonies. Meanwhile, livers with several large metastatic lesions (right) were strongly colonized by EBV-003 (indicated by solid white boundaries). 85% of these colonies were located within or immediately adjacent to active dividing tumor cells, indicated by the presence of dark blue nuclei (red arrows). In Fig. 20 B) a more detailed examination, the few colonies (1) present in the healthy liver tissue were insignificantly smaller than the bacteria in the metastatic lesion (2), which indicates that EBV-003 colonies grow tens of times more in the metastatic tissue than in the healthy liver tissue, in the upper part of the metastasis that preferentially colonizes (the red arrow to the right indicates the liver part with the metastatic lesion. The green arrow pointing to the left indicates the side of the healthy liver tissue. The red line indicates the boundary between the two). In Fig. 20 C) the size of the EBV-003 colonies in the metastatic lesion was 118 times larger than the size of the colonies in the healthy liver tissue, which indicates the ability of the bacteria to grow in order of size only within the tumor tissue (***, P=2.2x10⁻²⁶). Figures 21 A–B. Intracellular invasion of EBV-003 within spontaneous liver metastases. Figure 21 A) A significant number of non-flhDC-induced and induced EBV-003 invaded metastatic cancer cells within the liver (white arrows). Figure 21 B) 87% and 83% of non-induced and induced EBV-003, respectively, invaded or were immediately adjacent to cancer cells within the metastatic lesion. Figures 22A–B. Intracellular protein delivery of EBV-003 in hepatic metastatic breast cancer. Figure 22A) EBV-003 (green) delivers protein (red) into hepatic metastatic breast cancer cells (white arrows). Figure 22B) flhDC-induced EBV-003 delivered protein into metastatic tumor cells at a frequency three times higher than non-induced EBV-003. Specific details for implementing the invention

[0029] The majority of proteins are intracellular proteins. Using macromolecular therapies to specifically target intracellular pathways in cancer cells increases potential treatment options for any patient. However, macromolecular therapies targeting intracellular pathways face significant barriers related to tumor targeting, distribution, internalization, and endosome release. Engineered non-pathogenic Salmonella selectively colonizes 1,000 times more tumors than any other organelle and penetrates the cytosol of cancer cells to deliver therapeutic agents, making it an ideal bacterial delivery vehicle for cancer treatment.

[0030] However, a problem with using bacteria as anticancer agents is toxicity at the dosage required for therapeutic efficacy, and an obstacle in cancer gene therapy is that the treatment is directly targeted at the cancer. Another problem to be solved is the systemic elimination of Salmonella. Another problem is the activity of Cytosolic Salmonella (compared to SCV Salmonella). The present invention provides a novel therapeutic platform capable of treating cancer by controlling the colonization and / or invasion of engineered Salmonella in cancer cells and by regulating gene and protein delivery in cancer cells.

[0031] To address these challenges, a bacterial delivery platform utilizing the intrinsic mechanisms of Salmonella was developed to deliver intracellular protein-based drugs. When present within a tumor, Salmonella senses the intracellular environment and accumulates within the cell. By manipulating its genetic circuitry, it was forced into cancer cells to release proteins from endosomes into the cytoplasm. Intracellular lysis self-limits the platform and reduces the risk of unwanted infection. The delivered nanoantibodies and protein interactors (NIPP1) bind to their targets to induce cell death. Delivery of Caspase-3 to mice reduces the growth of breast tumors and eliminates liver tumors. Intracellular delivery of protein-based drugs to tumors opens up the entire protein for therapeutic purposes.

[0032] definition

[0033] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as generally understood by those skilled in the art to which the present invention pertains. Any method and material similar or equivalent to that described herein may be used in the practice or testing of the present invention, but various embodiments relating to the method and material are described herein. As used herein, each of the following terms has the meaning associated with it in this section.

[0034] For clarity and brevity, features may be described herein as part of identical or separate embodiments, but it will be understood that the scope of the invention may include embodiments having all or part of the described features.

[0035] References to “one embodiment”, “an embodiment,” etc. in this specification indicate that while the described embodiment may include specific aspects, features, structures, moiety, or characteristics, not all embodiments are required to include such aspects, features, structures, moiety, or characteristics. Furthermore, such phrases may refer to the same embodiments mentioned in other parts of this specification, but are not necessarily so. Additionally, when specific aspects, features, structures, moiety, or characteristics are described in relation to an embodiment, it is within the knowledge of those skilled in the art to influence or connect such aspects, features, structures, moiety, or characteristics to other embodiments, regardless of whether they have been explicitly described.

[0036] As used herein, the indefinite articles (“a,” “an,” and “the”) should be understood to include plural references unless the context clearly indicates otherwise.

[0037] As used herein, the phrase "and / or" should be understood to mean "either one or both" of elements thus combined, for example, elements that exist combined in some cases and separately in others.

[0038] As used herein, “or” should be understood to have the same meaning as “and / or” as defined above. For example, when separating a list of items, “and / or” or “or” should be interpreted as including, for example, one or more items, and optionally, additional unlisted items. Conversely, only clearly indicated terms, for example, “only one” or “exactly one,” or when used in claims, “constituting” will refer to the number of elements or including exactly one element of the list. In general, the term “or” as used herein is interpreted only as indicating an exclusive alternative (i.e., “one or the other, but not both”) when preceded by an exclusive term, such as “either”, “one of”, “only one”, or “exactly one”.

[0039] As used herein, the term "include" ("including," "includes," "having," "has," "with"), or variations thereof, is intended to be inclusive, similar to the term "comprising."

[0040] As used herein, the term “about” means ±10% of the indicated value. For example, about 100 means 90 to 110. The numerical ranges cited herein by the endpoint include all numbers and fractions contained within the range (e.g., 1 to 5 include 1, 1.5, 2, 2.75, 3, 3.90, 4, and 5). Furthermore, it should be understood that all numbers and fractions are presumed to be modified by the term “about”.

[0041] The terms “individual,” “subject,” and “patient” are used interchangeably herein and refer to any subject for whom diagnosis, treatment, or therapy is desired, including mammals. Mammals include, but are not limited to, humans, livestock, sports animals, and pets. “Subject” is a vertebrate such as a mammal, including humans. Mammals include, but are not limited to, humans, livestock, sports animals, and pets. The term “animal” includes dogs, cats, fish, gerbils, guinea pigs, hamsters, horses, rabbits, pigs, mice, monkeys (e.g., apes, gorillas, chimpanzees, orangutans), rats, sheep, goats, cattle, and birds.

[0042] The terms “treatment” (including “treatment” and “treating”) are used herein to generally mean obtaining a desired pharmacological and / or physiological effect, such as preventing or inhibiting the onset or progression of a disorder, or attempting to prevent or inhibit it, and / or reducing, inhibiting, regressing, or remissioning the disorder and / or its symptoms, or attempting to reduce, inhibit, regress, or remission it. The effect may be prophylactic in that it completely or partially prevents the disease or its symptoms, and / or therapeutic in that it causes partial or complete cure of the disease and / or adverse effects caused by the disease. As understood by those skilled in the art, various clinical and scientific methodologies and assays may be used to assess the onset or progression of a disorder, and similarly, various clinical and scientific methodologies and assays may be used to assess the reduction, regression, or remission of the disorder or its symptoms. Additionally, the treatment may be applied to subjects or cell cultures (in vivo or in vitro).

[0043] The term “inhibition” (“inhibit”, “inhibiting”, and “inhibition”) refers to slowing, stopping, or reversing the growth or progression of a disease, infection, pathological condition, cell population, protein, or expression thereof. Inhibition may exceed, for example, about 20%, 40%, 60%, 80%, 90%, 95%, or 99% of the growth or progression that would occur in the absence of treatment or contact.

[0044] "Expression" refers to the production of RNA from DNA and / or the production of proteins induced by genetic material (e.g., RNA (mRNA)). In contrast to constitutive expression (which is always expressed), inducible expression is expression that occurs only under specific conditions, such as the presence of a specific molecule (e.g., arabinose) or an environment.

[0045] With reference to nucleic acids (or proteins) and hosts, the term "exogenous" as used herein refers to nucleic acids that do not occur (and cannot be obtained) in that particular type of cell when found in nature or in proteins encoded by such nucleic acids. Therefore, non-naturally occurring nucleic acids are considered exogenous to the host once they are present in the host. It is important to note that non-naturally occurring nucleic acids may contain nucleic acid subsequences or fragments of nucleic acid sequences found in nature, even when the nucleic acid as a whole does not exist in nature. For example, a nucleic acid molecule containing a genomic DNA sequence within an expression vector is a non-naturally occurring nucleic acid and is therefore exogenous to the host cell after introduction into the host, because the nucleic acid molecule as a whole (genomic DNA + vector DNA) does not exist in nature. Thus, any vector that does not exist as a whole, an autonomously replicating plasmid, or a virus (e.g., retrovirus, adenovirus, or herpes virus) is considered a non-naturally occurring nucleic acid. This follows the principle that genomic DNA fragments generated by PCR or restriction endonuclease therapy, as well as cDNA, are considered non-naturally occurring nucleic acids because they exist as separate molecules not found in nature. Therefore, exogenous sequences can be incorporated into the host genome. Furthermore, it follows that any nucleic acid containing promoter sequences and polypeptide-coding sequences (e.g., cDNA or genomic DNA) in arrays not found in nature is a non-naturally occurring nucleic acid. Naturally occurring nucleic acids can be exogenous to a specific host microorganism. For example, an entire chromosome isolated from a cell of yeast x is an exogenous nucleic acid to the cell of yeast y once the chromosome is introduced into the cell of yeast y.

[0046] In contrast, the term “endogenous” as used herein in relation to nucleic acids (e.g., genes) (or proteins) and hosts refers to nucleic acids (or proteins) that occur in (and may be obtained from) a specific host found in nature. Furthermore, cells “endogenously expressing” nucleic acids (or proteins) express nucleic acids (or proteins) just like the same specific type of host found in nature. Additionally, a host “endogenously producing” nucleic acids, proteins, or other compounds produces nucleic acids, proteins, or compounds just like the same specific type of host found in nature.

[0047] Flagella are filamentous protein structures found in bacteria, synapsids, and eukaryotes, although they are most commonly found in bacteria. They are generally used to propel cells through fluids (i.e., bacteria and sperm). However, flagella have many other specialized functions. Flagella are typically found in Gram-negative bacilli. Gram-positive rods (e.g., Listeria species) and cocci (some Enterococcus species and Bagococcus species) also possess flagella.

[0048] The engineered Salmonella can be any Salmonella strain designed to lyse and deliver proteins within the cell.

[0049] The term "contact" refers to the act of making contact, directly or in close proximity, at the cellular or molecular level to induce, for example, a physiological reaction, a chemical reaction, or a physical change, for example, in a solution, a reaction mixture, in a test tube, or in vivo.

[0050] "Effective dose" is an amount sufficient to achieve a beneficial or desired outcome, such as preclinical or clinical results. The effective dose may be administered in one or more doses. As applied to the compound(s), biological agents, and pharmaceutical compositions described herein, the term "effective dose" means the amount required to produce a desired therapeutic outcome. For example, the effective dose is a level effective in treating, curing, or alleviating the symptoms of the disorder and / or disease to which the therapeutic compound, biological, or composition is administered. The effective dose for a specific desired therapeutic goal may depend on various factors, including the disorder being treated and its severity and / or stage of development / progression; said bioavailability, and the activity of the specific compound, the biological or pharmaceutical composition used; the route or method of administration and the site of introduction of the subject; the elimination rate of the specific compound or biological and other pharmacokinetic properties; the duration of treatment; the inoculation regimen; drugs, biological, or compositions used in combination with or simultaneously with the specific compound; age, weight, sex, diet, physiology and overall health of the subject being treated; and similar factors well known to a skilled person in the relevant scientific field. Some changes in dosage may occur depending on the condition of the patient being treated, and the physician or other individual administering the treatment will determine the appropriate dosage for the individual patient in any case.

[0051] As used herein, "disorder" refers to a disorder, disease, or pathological condition, or any other deviation from healthy or normal biological activity, and the terms may be used interchangeably. The term will refer to any pathological condition that impairs normal function. The pathological condition may be caused by sporadic or hereditary genetic abnormalities. The disease may also be caused by non-genetic abnormalities. The disease may also be caused by, but is not limited to, damage to the subject from environmental factors that cut, crush, burn, perforate, stretch, shear, inject, or otherwise deform the subject's cells(s), tissue(s), organ(s), system(s), etc.

[0052] The terms "cell," "cell line," and "cell culture" as used herein may be used interchangeably. All of these terms also include offspring, which are any subsequent generation. It is understood that not all offspring may be identical due to intentional or unintended mutations.

[0053] The "coding region" of a gene consists of nucleotide residues of the gene's coding strand and nucleotides of the gene's non-coding strand that are homologous to or mutually complementary to the coding region of the mRNA molecule produced by the transcription of the gene.

[0054] As used herein, "complementary" refers to the broad concept of subunit sequence complementarity between two nucleic acids, e.g., two DNA molecules. Nucleic acids are considered complementary to each other at positions where nucleotide locations in both molecules are occupied by nucleotides that normally form base pairs with each other. Thus, two nucleic acids are complementary to each other when a substantial number (at least 50%) of the corresponding locations in each molecule are occupied by nucleotides that normally form base pairs with each other (e.g., A:T and G:C nucleotide pairs). Thus, it is known that an adenine residue in a first nucleic acid region can form specific hydrogen bonds ("base pairings") with a residue in a second nucleic acid region that is antiparallel to the first region when the residue is thymine or uracil. Similarly, it is known that a cytosine residue in a first nucleic acid strand can form base pairs with a residue in a second nucleic acid strand that is antiparallel to the first strand when the residue is guanine. A first region of nucleic acid is complementary to a second region of the same or different nucleic acid if, when two regions are arranged in an antiparallel manner, at least one nucleotide residue of the first region can form a base pair with a residue of the second region. Preferably, the first region comprises a first portion and the second region comprises a second portion, so that when the first and second portions are arranged in an antiparallel manner, at least about 50%, and preferably at least about 75%, at least about 90%, or at least about 95% of the nucleotide residues of the first portion can form a base pair with a nucleotide residue of the second portion. More preferably, all nucleotide residues of the first portion can form a base pair with a nucleotide residue of the second portion.

[0055] "Encoding" refers to the unique characteristics of specific sequences of nucleotides within polynucleotides, such as genes, cDNA, or mRNA, and the biological properties arising therefrom, which act as templates for the synthesis of other polymers and macromolecules having defined nucleotide sequences (i.e., rRNA, tRNA, and mRNA) or defined amino acid sequences in biological processes. Thus, if the transcription and translation of mRNA corresponding to a gene produces a protein in a cell or other biological system, the gene is said to encode that protein. Both the coding strand, which is a nucleotide sequence identical to the mRNA sequence and commonly provided in sequence lists, and the non-coding strand, which is used as a template for the transcription of the gene or cDNA, may be referred to as encoding the protein or other product of the corresponding gene or cDNA.

[0056] As used herein, a "essentially pure" preparation of a specific protein or peptide is a preparation in which, by weight basis of the protein or peptide in the preparation, at least about 95%, preferably at least about 99%, of the specific protein or peptide is the preparation.

[0057] "Fragment" or "segment" is a part of an amino acid sequence containing at least one amino acid, or a part of a nucleic acid sequence containing at least one nucleotide. The terms "fragment" and "segment" are used interchangeably herein.

[0058] As used herein, "functional" biological molecules are forms of biological molecules that exhibit characteristic properties. For example, a functional enzyme is an enzyme that exhibits characteristic catalytic activity.

[0059] As used herein, "homology" refers to the similarity of subunit sequences between two polymer molecules, for example, between two nucleic acid molecules, for example, between two DNA molecules or two RNA molecules, or between two polypeptide molecules. If subunit positions in both molecules are occupied by the same monomeric subunit, for example, if positions in each of the two DNA molecules are occupied by adenine, they are homology at that position. Homology between two sequences is a direct function of the number of matching or homologous positions, for example, if half of the positions in the two compound sequences (e.g., 5 positions in 10 polymeric subunits of length) are homologous, the two sequences are 50% homologous, and if 90% of the positions, for example, 9 / 10 positions are matching or homologous, the two sequences share 90% homology. For example, DNA sequences 3'ATTGCC5' and 3'TATGGC share 50% homology.

[0060] As used herein, "homology" is used as a synonym for "identity."

[0061] The determination of the percentage of identity between two nucleotide or amino acid sequences can be achieved using mathematical algorithms. For example, a mathematical algorithm useful for comparing two sequences is the algorithm of Karlin and Altschul (1990, Proc. Natl. Acad. Sci. USA 87:2264-2268), modified as in Karlin and Altschul (see 1993, Proc. Natl. Acad. Sci. 90:5873-5877). These algorithms are integrated into the NBLAST and XBLAST programs of Altschul et al. (1990, J. Mol. Biol. 215:403-410) and are accessible, for example, on the National Center for Biotechnology Information (NCBI) World Wide website, which has a universal resource locator for using BLAST tools. BLAST nucleotide search may be performed using the NBLAST program (designated as "blastn" on the NCBI website) with the following parameters: gap penalty = 5; gap extension penalty = 2; mismatch penalty = 3; match reward = 1; expected value 10.0; and word size = 11 to obtain nucleotide sequences homologous to the nucleic acid described herein. BLAST protein search may be performed using the XBLAST program (designated as "blastn" on the NCBI website) or the NCBI "BLAST" program with the following parameters: expected value 10.0, using the BLOSUM62 scoring matrix to obtain amino acid sequences homologous to the protein molecule described herein. Gapped BLAST may be utilized to obtain gap alignment for comparison purposes, as described in Altschul et al. (1997, Nucleic Acids Res. 25:3389-3402). Alternatively, using PSI-Blast or PHI-Blast, molecules (Id.It is possible to perform iterative searches to detect relationships between molecules that share common patterns and distant relationships between them. When using BLAST, Gapped BLAST, PSI-Blast, and PHI-Blast programs, the default parameters of each program (e.g., XBLAST and NBLAST) may be used.

[0062] The percentage of identity between two sequences can be determined using a technique similar to the one described above, with or without a gap. When calculating the percentage of identity, an exact match is typically counted.

[0063] As used herein, the term "hybridization" refers to the pairing of complementary nucleic acids. Hybridization and hybridization strength (i.e., strength of association between nucleic acids) are influenced by factors such as the degree of complementarity between nucleic acids, the severity of the conditions involved, the length of the formed hybrid, and the G:C ratio within the nucleic acid.

[0064] As used herein, “directive material” comprises publications, records, diagrams, or any other expression medium that may be used to convey the utility of the peptide of the present invention in kits for the alleviation of various diseases or disorders cited herein. Optionally or alternatively, the directive material may describe one or more methods for alleviating diseases or disorders in mammalian cells or tissues. The directive material of the kit of the present invention may be attached to a container containing the identified compound invention, for example, or shipped together with a container containing the identified compound. Alternatively, the directive material may be shipped separately from the container with the intention that the directive material and the compound be used collaboratively by the recipient.

[0065] The term "nucleic acid" generally refers to large polynucleotides. "Nucleic acid" means any nucleic acid and includes all nucleic acids composed of deoxyribonucleosides or ribonucleosides, and composed of phosphodiester bonds or modified linkages such as phosphoramidates, siloxanes, carbonates, carboxymethyl esters, acetamidates, carbamates, thioethers, cross-linked phosphoramidates, bridging methylene phosphonates, phosphorothioates, sulfone bonds, and combinations of such linkages. The term nucleic acid also specifically includes nucleic acids composed of bases other than the five biologically occurring bases (adenine, guanine, thymine, cytosine, and uracil).

[0066] As used herein, the term "nucleic acid" includes RNA as well as single and double-stranded DNA and cDNA. Additionally, the terms "nucleic acid," "DNA," "RNA," and similar terms also include nucleic acid analogs, namely analogs other than phosphodiester backbones. For example, so-called "peptide nucleic acids" known in the art, having peptide bonds instead of phosphodiester bonds in the backbone, are considered to be within the scope of the present invention. "Nucleic acid" means any nucleic acid and includes all nucleic acids composed of deoxyribonucleoside or ribonucleoside, and composed of phosphodiester bonds or modified linkages such as phosphoramidate, siloxane, carbonate, carboxymethyl ester, acetamidate, carbamate, thioether, cross-linked phosphoramidate, bridged methylene phosphonate, cross-linked phosphoramidate, bridged methylene phosphonate, phosphorothioate, methylphosphonate, phosphorodithioate, and cross-linked phosphorothioate, or sulfone bonds and combinations of such linkages. The term nucleic acid also specifically includes nucleic acids composed of bases other than the five biologically occurring bases (adenine, guanine, thymine, cytosine, and uracil). Conventional notation is used herein to describe polynucleotide sequences: the left end of a single-stranded polynucleotide sequence is the 5' end; and the left direction of a double-stranded polynucleotide sequence is referred to as the 5' direction. The direction in which nucleotides are added to an initial RNA transcript from 5' to 3' is referred to as the transcription direction. A DNA strand having the same sequence as mRNA is referred to as the "coding strand"; a sequence on the DNA strand located at 5' to a reference point on the DNA is referred to as the "upstream sequence"; and a sequence on the DNA strand located at 3' to a reference point on the DNA is referred to as the "downstream sequence".

[0067] As used herein, the term "nucleic acid construct" includes DNA and RNA sequences encoding a specific desired gene or gene fragment, whether obtained by genomic or synthetic methods.

[0068] Unless otherwise specified, “nucleotide sequences encoding amino acid sequences” include all nucleotide sequences that are variant versions of each other and that encode the same amino acid sequence. Nucleotide sequences encoding proteins and RNA may include introns.

[0069] The term "oligonucleotide" generally refers to short polynucleotides, typically about 50 nucleotides or fewer. If a nucleotide sequence is represented as a DNA sequence (i.e., A, T, G, C), it will be understood that this also includes an RNA sequence (i.e., A, U, G, C) where "U" replaces "T".

[0070] "Substantially homologous nucleic acid sequences" means nucleic acid sequences corresponding to reference nucleic acid sequences, wherein the corresponding sequences encode peptides having substantially the same structure and function as the peptide encoded by the reference nucleic acid sequences; for example, only changes in amino acids do not significantly affect the peptide function. Preferably, substantially identical nucleic acid sequences encode the peptide encoded by the reference nucleic acid sequences. The percentage of identity between substantially similar nucleic acid sequences and reference nucleic acid sequences is at least about 50%, 65%, 75%, 85%, 95%, 99% or more. The substantial identity of nucleic acid sequences can be determined by comparing the sequence identity of two sequences, for example by physical / chemical methods (i.e., hybridization) or by sequence alignment using computer algorithms. Appropriate nucleic acid hybridization conditions for determining whether a nucleotide sequence is substantially similar to a reference nucleotide sequence are as follows: 7% sodium dodecyl sulfate SDS, 0.5 M NaPO4, 1 mM EDTA washed with 2X standard saline citrate (SSC) at 50°C, 0.1% SDS at 50°C; preferably 7% (SDS), 0.5 M NaPO4, 1 mM EDTA washed with 1X SSC at 50°C, 0.1% SDS at 50°C; preferably 7% SDS, 0.5 M NaPO4, 1 mM EDTA washed with 0X SSC at 50°C, 5X SSC, 0.1% SDS at 50°C; more preferably 7% SDS, 0.5 M NaPO4 washed with 0X SSC at 50°C, 1 mM EDTA washed with 0X SSC at 50°C, 0.1% SDS at 65°C. Computer algorithms suitable for determining substantial similarity between two nucleic acid sequences include the GCS program package (Devereux et al. 1984 Nucl. Acids Res. 12:387), and the BLASTN or FASTA programs (Altschul et al. 1990 Proc. Natl. Acad. Sci. USA).(See Altschul et al. 1990 87:14:5509-13; J. Mol. Biol. 1990 215:3:403-10; Altschul et al. 1997 Nucleic Acids Res. 25:3389-3402). The default settings provided with these programs are suitable for determining substantial similarity of nucleic acid sequences for the purposes of the present invention.

[0071] Describing two polynucleotides as "operably linked" means that a single-stranded or double-stranded nucleic acid moiety contains two polynucleotides arranged within the nucleic acid moiety in such a way that at least one of the two polynucleotides can exert the physiological effect characterized by the other. For example, a promoter operably linked to the coding region of a gene can promote the transcription of the coding region.

[0072] As used herein, the term “pharmaceuticalally acceptable carrier” means a chemical composition to which a suitable compound or derivative may be combined, and which, after combination, may be used to administer the suitable compound to a subject. “Pharmaceutically acceptable” means physiologically tolerable for human or animal application. As used herein, “pharmaceutical composition” includes formulations for humans and animals.

[0073] As used herein, the terms “purified” and similar terms refer to the concentration of a molecule or compound relative to other components normally associated with the molecule or compound in its natural environment. The term “purified” does not necessarily imply that the complete purity of a specific molecule has been achieved during the process. As used herein, “highly purified” compounds refer to compounds of greater than 90% purity. In particular, purified sperm cell DNA refers to DNA that does not produce significant detectable levels of non-sperm cell DNA upon PCR amplification of purified sperm cell DNA and subsequent analysis of the amplified DNA. “Significant detectable levels” is the amount of contamination visible in the presented data that must be addressed / described during the analysis of forensic evidence.

[0074] "Recombinant polynucleotides" refer to polynucleotides having sequences that are not naturally joined together. Amplified or assembled recombinant polynucleotides can be incorporated into a suitable vector, and the vector can be used to transform suitable host cells.

[0075] Recombinant polynucleotides can also provide non-coding functions (e.g., promoters, replication origins, ribosome-binding sites, etc.).

[0076] Host cells containing recombinant polynucleotides are referred to as "recombinant host cells." As genes expressed in recombinant host cells, genes containing recombinant polynucleotides produce "recombinant polypeptides."

[0077] "Recombinant polypeptide" is produced during the expression of recombinant polynucleotides.

[0078] "Recombinant cells" are cells containing a heterogeneous gene. Such cells may be eukaryotic or prokaryotic cells. Additionally, heterogeneous gene cells include, but are not limited to, embryonic stem cells containing a heterogeneous gene, cells obtained from chimeric mammals derived from heterogeneous gene embryonic stem cells, cells obtained from heterogeneous gene mammals, or their fetal or placental tissues, and prokaryotic cells containing a heterogeneous gene.

[0079] The term "regulation" refers to stimulating or inhibiting a function or activity of interest.

[0080] "Small interfering RNA (siRNA)" specifically refers to an isolated dsRNA molecule consisting of both sense and antisense strands. In one embodiment, it is greater than 10 nucleotides in length. siRNA also refers to a single transcript having both sense and complementary antisense sequences from a target gene (e.g., a hairpin). siRNA further includes any form of dsRNA (larger dsRNA, partially purified RNA, essentially pure RNA, synthetic RNA, recombinantly produced RNA) as well as naturally occurring RNA and other modified RNAs resulting from the addition, deletion, substitution, and / or alteration of one or more nucleotides.

[0081] As used herein, the term "specifically binding" means that a compound or ligand functions in a binding reaction or assay condition that determines the presence of a compound in a sample of heterogeneous compounds, or that a binding moiety, such as one molecule like an oligonucleotide or antibody, preferentially binds to another molecule, for example, a nucleic acid or protein of another molecule present therein.

[0082] The term “specific binding” (or “specifically binding”), when used in relation to the interaction between a peptide (ligand) and a receptor (molecule), also refers to an interaction dependent on the presence of a specific structure (i.e., the amino sequence of the ligand or ligand binding domain within the protein); that is, the peptide generally contains a structure that enables recognition and binding to a specific protein structure within the binding partner rather than the molecule. For example, in a reaction containing a labeled peptide ligand “A” (e.g., an isolated phage-displayed peptide or an isolated synthetic peptide) and an unlabeled “A,” in the presence of a protein containing binding pocket A, if the ligand is specific to binding pocket “A,” the unlabeled peptide ligand will reduce the amount of the labeled peptide ligand bound to the binding partner, i.e., the amount of competitive binding assay.

[0083] As used herein, the term "standard" refers to something used for comparison. For example, this may be a known standard formulation or compound administered and used to compare results when administering a test compound, or a standard parameter or function measured to obtain a control value when measuring the effect of a formulation or compound on a parameter or function. Standard may also refer to "internal standards," such as formulations or compounds added to a sample in a known amount and useful for determining things like purification or recovery rates when the sample is processed or undergoes purification or extraction procedures before the marker of interest is measured. Internal standards are often purified markers of interest labeled, such as radioisotopes, which allow them to be distinguished from endogenous markers.

[0084] Methods involving conventional molecular biology techniques are described herein. Such techniques are generally known in the art and are described in detail in methodological papers, e.g., *Molecular Cloning: A Laboratory Manual*, 2nd edition, vol. 1–3, ed. Sambrook et al., *Cold Spring Harbor Laboratory Press*, *Cold Spring Harbor*, NY, 1989; and *Current Protocols in Molecular Biology*, ed. Ausubel et al., *Greene Publishing and Wiley-Interscience*, New York, 1992 (with periodic updates). Methods for the chemical synthesis of nucleic acids are discussed, e.g., Beaucage and Carruthers, *Tetra. Letts. 22: 1859–1862*, 1981; and Mattemucci et al., *J. Am. Chem. Soc. 103:3185*, 1981.

[0085] As used herein, the term "include" ("including," "includes," "having," "has," "with") or variations thereof is intended to be inclusive, similar to the term "comprising" ("comprising").

[0086] Terms such as “comprises”, “comprising”, etc., may have the meanings assigned to them under U.S. patent law and may mean “includes”, “including”, etc. As used herein, “comprising” or “comprising” or similar means are included without limitation.

[0087] I. Bacteria / Flagells

[0088] Bacteria useful for the present invention include, but are not limited to, Clostridium, Bifidobacterium, Escherichia coli, or T3SS-dependent bacteria such as Salmonella, Shigella, Salmonella, and Yersinia pestis. Additionally, Escherichia coli may be used when the T3SS system is placed within Escherichia coli.

[0089] Salmonella

[0090] Examples of Salmonella strains that can be used in the present invention include Salmonella typhi (ATCC No. 7251) and Salmonella typhi (ATCC No. 13311). Attenuated Salmonella strains include S. typhi-aroC-aroD (Hone et al., Vacc. 9:810 (1991)), *S. typhi-aroA* mutant (Mastroeni et al., Micro. Pathol. 13:477 (1992)), and *S. typhi-aroA* 7207. Additional attenuated Salmonella strains that may be used in the present invention include one or more of the following other attenuated mutants: (i) aro (Hoiseth et al., Nature, 291:238-239 (1981)), gua (McFarland et al., Microbiol. Path., 3:129-141 (1987)), nad (Park et al., J. Bact, 170:3725-3730 (1988), thy (Nnalue et al., Infect. Immun., 55:955-962 (1987)), and asd (Curtiss, supra) mutations; (ii) cya (Curtiss et al., Infect. Immun., 55:3035-3043 (1987)), crp (Curtiss et al., (1987), supra), phoP / phoQ (Groisman et al., Proc. Natl. Acad. Sci., USA, 86:7077-7081 (1989); and Miller et al., Proc. Natl. Acad. Sci., USA, 86:5054-5058 (1989)), phop.sup.c (Miller et al., J. Bact, 172:2485-2490 (1990)) or ompR (Dorman et al., Infect. Immun., 57:2136-2140 (1989)) mutations and Mutations that inactivate the same global regulatory function; (iii) recA (Buchmeier et al., MoI. Micro., 7:933-936 (1993)), htrA (Johnson et al., MoI. Micro.Mutations that modify stress responses, such as htpR (Neidhardt et al., Biochem. Biophys. Res. Com., 100:894-900 (1981)), hsp (Neidhardt et al., Ann. Rev. Genet, 18:295-329 (1984)) and groEL (Buchmeier et al., Sci., 248:730-732 (1990)) mutations; (iv) mutations of specific toxic factors such as IsyA (Libby et al., Proc. Natl. Acad. Sci., USA, 91:489-493 (1994)), pag or prg (Miller et al. (1990), supra; and Miller et al. (1989), supra), iscA or virG (d'Hauteville et al., MoI. Micro., 6:833-841 (1992)), plcA (Mengaud et al., Mol. Microbiol., 5:367-72 (1991); Camilli et al., J. Exp. Med, 173:751-754 (1991)), and act (Brundage et al., Proc. Natl. Acad. Sci., USA, 90:11890-11894 (1993)) mutations; (v) Mutations affecting DNA topology such as upstream A (Galan et al., Infect. Immun., 58: 1879-1885 (1990)); (vi) Mutations disrupting or altering the cell cycle such as min (de Boer et al., Cell, 56:641-649 (1989)); (vii) Introduction of genes encoding suicide systems, e.g., sacB (Recorbet et al., App. Environ. Micro., 59:1361-1366 (1993); Quandt et al., Gene, 127:15-21 (1993)), nuc (Ahrenholtz et al., App. Environ. Micro.(viii) mutations that alter the bioproduction of lipopolysaccharides and / or lipid A, such as rFb (Raetz in Esherishia coli and rat typhus, Neidhardt et al., Ed., ASM Press, Washington DC pp 1035-1063 (1996)), galE (Hone et al., J. Infect. Dis., 156:164-167 (1987)) and htrB (Raetz, supra), msbB (Raetz, supra; and US Patent No. 7,514,089); and (ix) introduction of bacteriophage lysis systems such as lysogen encoded by P22 (Rennell et al., Virol, 143:280-289 (1985)), lambda-murein transglycosylase (Bienkowska-Szewczyk et al., Mol. Gen. Genet., 184:111-114 (1981)) or S-gene (Reader et al., Virol, 43:623-628 (1971)).

[0091] Attenuation mutations may be constitutively expressed or under the control of inducible promoters such as the temperature-sensitive heat shock family of promoters (Neidhardt et al. mentioned above) or the anaerobic-induced nirB promoter (Harbome et al., Mol. Micro., 6:2805-2813 (1992)) or repressive promoters such as uapA (Gorfinkiel et al., J. Biol. Chem., 268:23376-23381 (1993)) or gcv (see Stauffer et al., J. Bact, 176:6159-6164 (1994)).

[0092] In one embodiment, the bacterial delivery system is based on a non-toxic, attenuated Salmonella strain having a partial deletion of the msbB gene. This deletion reduces the TNF immune response to bacterial lipopolysaccharides and prevents septic shock. In another embodiment, it also has a partial deletion of the purI gene. This deletion makes the bacteria dependent on an external purine source and accelerates clearance from non-cancerous tissues (13). In mice, the toxicity of the therapeutic strain (LD50) 50 ) is 10,000 times smaller than wild-type Salmonella (72, 73). In preclinical studies, attenuated Salmonella was administered systemically to mice and dogs without toxic side effects (17, 27). Two FDA-approved Phase 1 clinical trials were conducted and demonstrated that this therapeutic strain can be safely administered to patients (20). In one embodiment, the bacterial strain is VNP20009, a derivative strain of *Rodentella typhi*. Deletion of two genes, msbB and purI, resulted in complete attenuation (by preventing toxic shock in the animal host) and dependence on an external source of purine for survival. This dependence prevents the organism from replicating in normal tissues such as the liver or spleen, but allows it to still grow in tumors where purine is available.

[0093] In addition, the insertion of a fail-safe circuit into a bacterial vector eliminates the need for antibiotics to eliminate bacteria (e.g., Salmonella), prevents unwanted infections, and defines the end of treatment.

[0094] flagellum

[0095] 1) flhDC sequence

[0096] In one embodiment, the flhDC sequence is a double-strone, flhDC coding region found in the strain *Rosemaryella typhi* 14028s or its derivatives.

[0097] Registration Number-

[0098] fhD-NCBI reference sequence: NC_016856.1

[0099] flhC- NCBI reference sequence: NC_016856.1

[0100] double cistron DNA sequence

[0101] ATGCATACATCCGAGTTGCTAAAACACATTTATGACATCAATTTGTCATATTTACTCCTTGCACAGCGTTTGATCGTCCAGGACAAAGCATCTGCGATGTTCCGCCTCGGTATCAACGAAGAGATGGCAAACACACTGGGCGCGTTGACCCTGCCGCAGATGGTCAAACTGGCGGAGACGAACCAGTTAGTTTGTCATTTCCGGTTTGACGATCATCAGACGATCACCCGTTTGACTCAGGATTCGCGCGTCGATGACTTACAGCAGATTCACACAGGTATCATGCTTTCAACGCGTCTGCTCAATGAAGTGGACGATACGGCGCGTAAGAAAAGGGCATGATAATGAGTGAAAAAAGCATTGTTCAGGAAGCTCGCGATATCCAGTTGGCGATGGAGTTGATTAATCTTGGCGCTCGTCTACAAATGCTGGAAAGCGAAACACAGCTCAGCCGTGGTCGCCTCATCAGGCTGTACAAAGAATTACGCGGTAGCCCGCCGCCTAAAGGGATGCTGCCATTTTCGACAGACTGGTTTATGACCTGGGAGCAAAATATTCATGCCTCCATGTTCTGCAACGCCTGGCAATTTTTACTGAAGACCGGCTTATGCAGCGGTGTGGATGCGGTGATTAAAGCTTATCGGCTTTATCTTGAGCAGTGTCCGCAACCGCCTGAAGGGCCGTTGTTGGCGCTGACTCGCGCATGGACGCTGGTGCGTTTTGTTGAAAGTGGGTTGCTTGAATTGTCGAGCTGTAACTGCTGCGGTGGGAACTTTATTACCCATGCGCATCAGCCCGTAGGCAGCTTTGCGTGTAGTTTATGCCAGCCGCCATCCCGCGCAGTAAAAAGACGTAAACTTTCCCGAGATGCTGCCGATATTATTCCACAACTGCTGGATGAACAGATCGAACAGGCTGTTTAA (서열번호 1)

[0102] Protein sequence

[0103] flhD

[0104] MHTSELLKHIYDINLSYLLLAQRLIVQDKASAMFRLGINEEMANTLGALTLPQMVKLAETNQLVCHFRFDDDHQTITRLTQDSRVDDLQQIHTGIMLSTRLLNEVDDTARKKRA (SEQ ID NO: 2)

[0105] flhC

[0106] MSEKSIVQEARDIQLAMELINLGARLQMLESETQLSRGRLIRLYKELRGSPPPKGMLPFSTDWFMTWEQNIHASMFCNAWQFLLKTGLCSGVDAVIKAYRLYLEQCPQPPEGPLLALTRAWTLVRFVESGLLELSSCNCCGGNFITHAHQPVGSFACSLCQPPSRAVKRRKLSRDAADIIPQLLDEQIEQAV (SEQ ID NO: 3)

[0107] Other sequences may also be used to regulate flagellar activity, including, for example, motA, motB, flhE, cheZ, cheY cheB, cheR, cheM, cheW, cheA, fliA, fliY, fliZ, fliB, fliS, fliE, fliF, fliJ, fliL, fliM, fliN, fliO, flip, fliQ, fliR, fliG, fliH, fliI, fliT, fliD, fliC, fljB, ycrG, flgN, flgM, flgA, flgB, flgC, flgD, flgE, flgF, flgG, flgH, flgI, flgJ, flgK and / or flgL.

[0108] motA, WP_000906312.1

[0109] >WP_000906312.1 Multivarie: Flagellar motility stabilizer protein MotA [Salmonella]

[0110] MLILLGYLVVIGTVFGGYVMTGGHLGALYQPAELVIIGGAGIGAFIVGNNGKAIKGTMKAIPLLFRRSKYTKSMYMDLLALLYRLMAKSRQQGMFSLERDIENPKESEIFASYPRILADAVMLDFIVDYLRLIISGNMNTFEIEALM DEEIETHESEAEVPANSLAMVGDSLPAFGIVAAVMGVVHALASADRPAAELGALIAHAMVGTFLGILLAYGFISPLATVLRQKSAETTKMMQCVKITLLSNLNGYAPPIAVEFGRKTLYSSERPSFIELEEHVRAVRNPNQQQTTEEA (SEQ ID NO: 4)

[0111] motB, WP_000795653.1

[0112] >WP_000795653.1 Multivarie: Flagellar motor protein MotB [Salmonella]

[0113] MKNQAHPIVVVKRRRHKPHGGGAHGSWKIAYADFMTAMMAFFLVMWLISISSPKELIQIAEYFRTPLATAVTGGGNRIANSESPIPGGGDDYTQQQGEVEKQPNIDELKKRMEQSRLNKLRGDLDQLIESDPKLRALRPHLKIDLVQEGLRIQII DSQNRPMFKTGSAEVEPYMRDILRAIAPVLNGIPNRISLAGHTDDFPYANGEKGYSNWELSADRANASRRELVAGGLDNGKVLRVVGMAATMRLSDRGPDDAINRRISLLVLNKQAEQAILHENAESQNEBVSVLQQPAAAPPASVPTSPKKAEPR (SEQ ID NO: 5)

[0114] flhE, WP_001233619.1

[0115] >WP_001233619.1 Multi-type: Flagellar protein FlhE [Salmonella]

[0116] MRKWLALLLFPLTVQAAGEGAWQDSGMGVTLNYRGVSASSSPLSARQPVSGVMTLVAWRYELNGPTPAGLRVRLCSQSRCVELDGQSGTTHGFAHVPAVEPLRFVWEVPGGGRLIPALKVRSNQVIVNYR (SEQ ID NO: 6)

[0117] cheZ, WP_000983586.1

[0118] >WP_000983586.1 Multi-type: Protein Phosphate CheZ [Salmonella]

[0119] MMQPSIKPADEGSAGDIIARIGSLTRMLRDSLRELGLDQAIAEAAEAIPDARDRLDYVVQMTAQAAERALNSVEASQPHQDAMEKEAKALTQRWDEWFDNPIELSDA RELVTDTRQFLRDVPGHTSFTNAQLLDIMMAQDFQDLTGQVIKRMMDVIQEIERQLLMVLLENIPEQSARPKRENESLLNGPQVDTSKAGVVASQDQVDDLLDSLGF (SEQ ID NO: 7)

[0120] cheY WP_000763861.1

[0121] >WP_000763861.1 Multi-type: Chemotactic reaction regulator CheY [Salmonella]

[0122] MADKELKFLVVDDFSTMRRIVRNLLKELGFNNVEEAEDGVDALNKLQAGGFGFIISDWNMPNMDGLELLKTIRADSAMSALPVLMVTAEAKKENIIAAAQAGASGYVVKPFTAATLEEKLNKIFEKLGM (SEQ ID NO: 8)

[0123] cheB, WP_000036392.1

[0124] >WP_000036392.1 Multi-type: Protein-glutamate methylesterase / Protein glutamine deamidase [Salmonella]

[0125] MSKIRVLSVDDSALMRQIMTEIINSHSDMEMVATAPDPLVARDLIKKFNPDVLTLDVEMPRMDGLDFLEKLMRLRPMPVVMVSSLTGKGSEVTLRALELGAIDFVTKPQLGIREGMLAYSEMIAEKVRTAARARIAAHKPMAAPTTLKAGPLLSSEKLIAIGASTGGTEAIRHV LQPLPLSSPAVIITQHMPPGFTRSFAERLNKLCQISVKEAEDGERVLPGHAYIAPGDKHMELARSGANYQIKIHDGPPVNRHRPSVDVLFHSVAKHAGRNAVGVILTGMGNDGAAGMLAMYQAGAWTIAQNEASCVVFGMPREAINMGGVSEVVDLSQVSQQMLAKISAGQAIRI (SEQ ID NO: 9)

[0126] cheR, WP_000204362.1

[0127] >WP_000204362.1 Multi-type: Protein-Glutamate O-Methyltransferase CheR [Salmonella]

[0128] MTSSLPSGQTSVLLQMTQRLALSDAHFRRICQLIYQRAGIVLADHKRDMVYNRLVRRLRALGLDDFGRYLSMLEANQNSAEWQAFINALTTNNLTAFFREAHHFPILAEHARRRHGEYRVWSAAASTGEEPYSIAITLADALGMA PGRWKVFASDIDTEVLEKARSGIYRLSELKTLSPQQLQRYFMRGTGPHEGLVRVRQELANYVEFSSVNLLEKQYNVPGPFDAIFCRNVMIYFDKTTQEDILRRFVPLLKPDGLLFAGHSENFSNLVREFSLRGQTVYALSKDKA (SEQ ID NO: 10)

[0129] cheM, WP_000483274.1

[0130] >WP_000483274.1 Multivarie: Methyl-tolerant chemotactic protein II [Salmonella]

[0131] MFNRIRVVTMLMMVLGVFALLQLVSGGLLFSSLQHNQQGFVISNELRQQQSELTSTWDLMLQTRINLSRSAARMMMDASNQQSSAKTDLLQNAKTTLAQAAAHYANFKNMTPLPAMAEASANVDEKYQRYQAALAELI QFLDNGNMDAYFAQPTQGMQNALGEALGNYARVSENLYRQTFDQSAHDYRFAQWQLGVLAVVLVLILMVVWFGIRHALLNPLARVITHIREIASGDLTKTLTVSGRNEIGELAGTVEHMQRSLIDTVTQVREGSDAIY SGTSEIAAGNTDLSSRTEQQASALEETAASMEQLTATVKQNADNARQASQLAQSASETARHGGKVVDGVVNTMHEIADSSKKIADIISVIDGIAFQTNILALNAAVEAARAGEQGRGFAVVAGEVRNLASRSAQAAKE IKALIEDSVSRVDTGSVLVESAGETMTDIVNAVTRVTDIMGEIASASDEQSRGIDQVALAVSEMDRVTQQNASLVQESAAAAAALEEQASRLTQAVSAFRLASRPLAVNKPEMRLSVNAQSGNTPQSLAARDDANWETF (SEQ ID NO: 11)

[0132] cheW, WP_000147295.1

[0133] >WP_000147295.1 Multi-type: Chemotactic protein CheW [Salmonella]

[0134] MTGMSNVSKLAGEPSGQEFLVFTLGNEEYGIDILKVQEIRGYDQVTRIANTPAFIKGVTNLRGVIVPIVDLRVKFCEGDVEYDDNTVVIVLNLGQRVVGIVVDGVSDVLSLTAEQIRPAPEFAVTLSTEYLTGLGALGERMLILVNIEKLLNSEEMALLDIAASHVA (SEQ ID NO: 12)

[0135] cheA, WP_000061302.1

[0136] >WP_000061302.1 Multi-type: Chemotactic protein CheW [Salmonella]

[0137] MSMDISDFYQTFFDEADELLADMEQHLLDLVPESPDAEQLNAIFRAAHSIKGGAGTFGFTILQETTHLMENLLDEARRGEMQLNTDIINLFLETKDIMQEQLDAYKNSEEPDAASFEYICNALRQLALEAKGETTPAVVETAALSAAIQEESVAETESPRDESKLRI VLSRLKANEVDLLEEELGNLATLTDVVVKGADSLSATLDGSVAEDDIVAVLCFVIEADQIAFEKVVAAPVEKAQEKTEVAPVAPPAVVAPAAKSAAHEHHAGREKPARERESTSIRVAVEKVDQLINLVGELVITQSMLAQRSNELDPVNHGDLITSMGQLQRNARDLQ ESVMSIRMMPMEYVFSRFPRLVRDLAGKLGKQVELTLVGSTELDKSLIERIIDPLTHLVRNSLDHGIEMPEKRLEAGKNVVGNLILSAEHQGGNICIEVTDDGAGLNRERILAKAMSQGMAVNENMTDDEVGMLIFAPGFSTAEQVTDVSGRGVGMDVVKRNIQEMG GHVEIQSKQGSGTTIRILLPLTLAILDGMSVRVAGEVFILPLNAVMESLQPREEDLHPLAGGERVLEVRGEYLPLVELWKVFDVDGAKTEATQGIVVILQSAGRRYALLVDQLIGQHQVVVKNLESNYRKVPGISAATILGDGSVALIVDVSALQGLNREQRMAITAA (SEQ ID NO: 13)

[0138] fliA, WP_001087453.1

[0139] >WP_001087453.1 Multi-type: RNA polymerase sigma factor FliA [Salmonella]

[0140] MNSLYTAEGVMDKHSLWQRYVPLVRHEALRLQVRLPASVELDDLLQAGGIGLLNAVDRYDALQGTAFTTYAVQRIRGAMLDELRSRDWVPRSVRRNAREVAQAMGQLEQELGRNATETE VAERLGIPVAEYRQMLLDTNNSQLFSYDEWREEHGDSIELVTEEHQQENPLHQLLEGDLRQRVMDAIESLPEREQLVLTLYYQEELNLKEIGAVLEVGESRVSQLHSQAIKRLRTKLGKL (SEQ ID NO: 14)

[0141] fliY, WP_000761635.1

[0142] >WP_000761635.1 Multitype: Cystine ABC transporter substrate binding protein [Salmonella]

[0143] MKLALLGRQALMGVMAVALVAGMSAKSFADEGLLNKVKERGTLLVGLEGTYPPFSFQGEDGKLTGFEVDFAEALAKHLGVKASLKPTKWDGMLASLDAKRIDVVINQVTISDVRKKKYDFSTPYTVSGIQALV KKGNEGTIKTAADLQGKKVGVGLGTNYEEWLRQHVQGVDIRTYDDDPTKYQDLRVGRIDAILVDRLAALDLVKKTKGTLAVTGDAFSRQESGVALRKGNEDLLKAVDNAIAEMQKDGTLKALSEKWFGADVTQ (SEQ ID NO: 15)

[0144] fliZ, WP_000218080.1

[0145] >WP_000218080.1 Multi-type: Flagellar biosynthesis regulatory protein FliZ [Salmonella]

[0146] MTVQQPKRRPLSRYLKDFKHSQTHCAHCHKLLDRITLVRRGKIVNKIAISQLDMLLDDAAWQREQKEWVALCRFCGDLHCKKQSDFFDIIGFKQYLFEQTEMSHGTVREYVVRLRRLGNYLSEQNISHDLLQDGFLDESLAPWLPETSTNNYRIALRKYQQYKAHQQIAPRQKSPFTASSDIY (SEQ ID NO: 16)

[0147] fliB, WP_000079794.1

[0148] >WP_000079794.1 Multitype: FliC / FljB series flagella [Salmonella]

[0149] MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRV SGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDSLNVQKAYDVKDTAVTTKAYANNGTTLDVSGLDDAAIKAATGGTNGTASVTGGAVKFDADNNKYFVTIGGFTGADAAKNGDY EVNVATDGTVTLAAGATKTTMPAGATTKTEVQELKDTPAVVSADAKNALIAGGVDATDANGAELVKMSYTDKNGKTIEGGYALKAGDKYYAADYDEATGAIKAKTTSYTAADGTTKTAANQLGGVD GKTEVVTIDGKTYNASKAAGGHDFKAQPELAEAAAKTTENPLQKIDAALAQVDALRSDLGAVQNRFNSAITNLGNTVNNLSEARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR (SEQ ID NO: 17)

[0150] fliS, WP_000287764.1

[0151] >WP_000287764.1 Multi-type: Flagella export saffron FliS [Salmonella]

[0152] MYTASGIKAYAQVSVESAVMSASPHQLIEMLFDGANSALVRARLFLEQGDVVAKGEALSKAINIIDNGLKAGLDQEKGGEIATNLSELYDYMIRRLLQANLRNDAQAIEEVEGLLSNIAEAWKQISPKASFQESR (SEQ ID NO: 18)

[0153] fliE, WP_000719036.1

[0154] >WP_000719036.1 Multivarie: Flagellar hook-basal complex protein FliE [Salmonella]

[0155] MAAIQGIEGVISQLQATAMAARGQDTHSQSTVSFAGQLHAALDRISDRQAAARVQAEKFTLGEPGIALNDVMADMQKASVSMQMGIQVRNKLVAAYQEVMSMQV (SEQ ID NO: 19)

[0156] fliF, WP_001276834.1

[0157] >WP_001276834.1 Multivarie: Flagellar M-ring protein FliF [Salmonella]

[0158] MSATASTATQPKPLEWLNRLRANPRIPLIVAGSAAVAIVVAMVLWAKTPDYRTLFSNLSDQDGGAIVAQLTQMNIPYRFANGSGAIEVPADKVHELRLRLAQQGLPKGGAVGFELLDQEKFGISQFSEQVNYQRALEGEL ARTIETLGPVKSARVHLAMPKPSLFVREQKSPSASVTVTLEPGRALDEGQISAVVHLVSSAVAGLPPGNVTLVDQSGHLLTQSNTSGRDLNDAQLKFANDVESRIQRRIEAILSPIVGNGNVHAQVTAQLDFANKEQTEE HYSPNGDASKATLRSRQLNISEQVGAGYPGGVPGALSNQPAPPNEAPIATPPTNQQNAQNTPQTSTSTNNSNSAGPRSTQRNETSNYEVDRTIRHTKMNVGDIERLSVAVVVNYKTLADGKPLPLTADQMKQIEDLTREAM GFSDKRGDTLNVVNSPFSAVDNTGGELPFWQQQSFIDQLLAAGRWLLVLVVAWILWRKAVRPQLTRRVEEAKAAQEQAQVRQETEEAVEVRLSKDEQLQQRRANQRLGAEVMSQRIREMSDNDPRVVALVIRQWMSNDHE (SEQ ID NO: 20)

[0159] fliJ, WP_000046981.1

[0160] >WP_000046981.1 Multi-type: Flagellar biosynthetic chaperone FliJ [Salmonella]

[0161] MAQHGALETLKDLAEKEVDDAARLLGEMRRGCQQAEEQLKMLIDYQNEYRSNLNTDMGNGIASNRWINYQQFIQTLEKAIEQHRLQLTQWTQKVDLALKSWREKKQRLQAWQTLQDRQTAAALLAENRMDQKKMDEFAQRAAMRKPE (SEQ ID NO: 21)

[0162] fliL, WP_000132169.1

[0163] >WP_000132169.1 Multivarie: Flagellar basal body associated protein FliL [Salmonella]

[0164] MTDSAINKKSKRSIWIPLLVLITLAACATAGYSYWRMQQQPTTNAKAEPAPPPPAVFFALDTFTVNLGDADRVLYIGVTLRLKDEATRARLNEYLPEVRSRLLLLFSRQNAAELSTEAGKQKLIAAIKETLAAPLVAGQPKQVVTDVLYTAFILR (SEQ ID NO: 22)

[0165] fliM, WP_000502811.1

[0166] >WP_000502811.1 Multivarie: Flagellar movement switch protein FliM [Salmonella]

[0167] MGDSILSQAEIDALLNGDSDTKDEPTPGIASDSDIRPYDPNTQRRVVRERLQALEIINERFARQFRMGLFNLLRRSPDITVGAIRIQPYHEFARNLPVPTNLNLIHLKPLRGTGLVVFSPSLVFIAVDNLFGGDGRFPTKVEGREFTHTEQRVINRMLKLALEGYSD AWKAINPLEVEYVRSEMQVKFTNITTSPNDIVVNTPFHVEIGNLTGEFNICLPFSMIEPLRELLVNPPLENSRHEDQNWRDNLVRQVQHSELELVANFADIPLRLSQILKLKPGDVLPIEKPDRIIAHVDGVPVLTSQYGTVNGQYALRVEHLINPILNSLNEEQPK (SEQ ID NO: 23)

[0168] fliN, WP_001282115.1

[0169] >WP_001282115.1 Multivarie: Flagellar Motility Transition Protein FliN [Salmonella]

[0170] MSDMNNPSDENTGALDDLWADALNEQKATTTKSAADAVFQQLGGGDVSGAMQDIDLIMDIPVKLTVELGRTRMTIKELLRLTQGSVVALDGLAGEPLDILINGYLIAQGEVVVVADKYGVRITDIITPSERMRRLSR (SEQ ID NO: 24)

[0171] fliO, WP_000978276.1

[0172] >WP_000978276.1 Multivarie: Flagellar type III secretory system protein FliO [Salmonella]

[0173] MMKTEATVSQPTAPAGSPLMQVSGALIGIALILAAAWVIKRMGFAPKGNSVRGLKVSASASLGPRERVVIVEVENARLVLGVTASQINLLHTLPPAENDTEAPVAPPADFQNMMKSLLKRSGRS (SEQ ID NO: 25)

[0174] fliP, WP_001253410.1

[0175] >WP_001253410.1 Multivarie: Flagellar type III secretory system stomatal protein FliP [Salmonella]

[0176] MRRLLFLSLAGLWLFSPAAAAQLPGLISQPLAGGGQSWSLSVQTLVFITSLTFLPAILLMMTSFTRIIIVFGLLRNALGTPSAPPNQVLLGLALFLTFFIMSPVIDKIYVDAYQPFSEQKIS MQEALDKGAQPLRAFMLRQTREADLALFARLANSGPLQGPEAVPMRILLPAYVTSELKTAFQIGFTIFIPFLIIDLVIASVLMALGMMMMVPPATIALPFKLMLFVLVDGWQLLMGSLAQSFYS (SEQ ID NO: 26)

[0177] fliQ, WP_000187355.1

[0178] >WP_000187355.1 Multivarie: Flagellar biosynthetic protein FliQ [Salmonella]

[0179] MTPESVMMMGTEAMKVALALAAPLLLVALITGLIISILQAATQINEMTLSFIPKIVAVFIAIIVAGPWMLNLLLDYVRTLFSNLPYIIG (SEQ ID NO: 27)

[0180] fliR, WP_000616953.1

[0181] >WP_000616953.1 Multivarie: Flagellar type III secretory system protein FliR [Salmonella]

[0182] MIQVTSEQWLYWLHLYFWPLLRVLALISTAPILSERAIPKRVKLGLGIMITLVIAPSLPANDTPLFSIAALWLAMQQILIGIALGFTMQFAFAAVRTAGEFIGLQMGLSFATFVDGSHLNMPVLARIMDML AMLLFLTFNGHLWLISLLVDTFHTLPIGSNPVNSNAFMALARAGGLIFLNGLMLALPVITLLLTLNLALGLLNRMAPQLSIFVIGFPLTLTVGIMLMAALMPLIAPFCEHLFSEIFNLLADIVSEMPINNNP (SEQ ID NO: 28)

[0183] fliG, WP_000067735.1

[0184] >WP_000067735.1 Multivarie: Flagellar movement switch protein FliG [Salmonella]

[0185] MSNLSGTDKSVILLMTIGEDRAAEVFKHLSTREVQALSTAMANVRQISNKQLTDVLSEFEQEAEQFAALNINANEYLRSVLVKALGEERASSLLEDILETRDTTSGIETLNFMEPQSAADLIRDEHPQIIATILVHLKRSQAADILALFDERLRHDVMLRIATFG GVQPAALAELTEVLNGLLDGQNLKRSKMGGVRTAAEIINLMKTQQEEAVITAVREFDGELAQKIIDEMFLFENLVDVDDRSIQRLLQEVDSESLLIALKGAEPPLREKFLRNMSQRAADILRDDLANRGPVRLSQVENEQKAILLIVRRLAETGEMVIGSGEDTYV (SEQ ID NO: 29)

[0186] fliH, WP_000064163.1

[0187] >WP_000064163.1 Multivarie: Flagellar assembly protein FliH [Salmonella]

[0188] MSNELPWQVWTPDDLAPPPETFVPVEADNVTLTEDTPEPELTAEQQLEQELAQLKIQAHEQGYNAGLAEGRQKGHAQGYQEGLAQGLEQGQAQAQTQQAPIHARMQQLVSEFQNTLD ALDSVIASRLMQMALEAARQVIGQTPAVDNSALIKQIQQLLQQEPLFSGKPQLRVHPDDLQRVEEMLGATLSLHGWRLRGDPTLHHGGCKVSADEGDLDASVATRWQELCRLAAPGVL (SEQ ID NO: 30)

[0189] fliI, WP_000213257.1

[0190] >WP_000213257.1 Multivarie: Flagella-specific ATP synthase FliI [Salmonella]

[0191] MTTRLTRWLTALDNFEAKMALLPAVRRYGRLTRATGLVLEATGLQLPLGATCIIERQDGPETKEVESEVVGFNGQRLFLMPLEEVEGILPGARVYARNGHGDGLQSGKQLPLGP ALLGRVLDGGGKPLDGLPAPDTLETGALITPPFNPLQRTPIEHVLDTGVRAINALLTVGRGQRMGLFAGSGVGKSVLLGMMARYTRADVIVVGLIGERGREVKDFIENILGPDG RARSVVIAAPADVSPLLRMQGAAYATRIAEDFRDRGQHVLLIMDSLTRYAMAQREIALAIGEPPATKGYPPSVFAKLPALVERAGNGIHGGGSITAFYTVLTEGDDQQDPIADS ARAILDGHIVLSRRLAEAGHYPAIDIEASISRAMTALITEQHYARVRLFKQLLSSFQRNRDLVSVGAYAKGSDPMLDKAITLWPQLEAFLQQGIFERADWEDSLQALDLIFPTV (SEQ ID NO: 31)

[0192] fliT, WP_000204899.1

[0193] >WP_000204899.1 Multivarie: Flagellar biosynthesis regulatory protein FliT [Salmonella]

[0194] MTSTVEFINRWQRIALLSQSLLELAQRGEWDLLLQQEVSYLQSIETVMEKQTPPGITRSIQDMVAGYIKQTLDNEQLLKGLLQQRLDELSSLIGQSTRQKSLNNAYGRLSGMLLVPDAPGAS (SEQ ID NO: 32)

[0195] fliD, WP_000146802.1

[0196] >WP_000146802.1 Multivarie: Flagellar filament capping protein FliD [Salmonella]

[0197] MASISSLGVGSNLPLDQLLTDLTKNEKGRLTPITKQQSANSAKLTAYGTLKSALEKFQTANTALNKADLFKSTVASSTTEDLKVSTTAGAAAGTYKINVTQLAAAQSLATKTTFAT TKEQLGDTSVTSRTIKIEQPGRKEPLEIKLDKGDTSMEAIRDAINDADSGIAASIVKVKENEFQLVLTANSGTDNTMKITVEGDTKLNDLLAYDSTTNTGNMQELVKAENAKLNVNG IDIERQSNTVTDAPQGITLTLTKKVTDATVTVTKDDTKAKEAIKSWVDAYNSLVDTFSSLTKYTAVEPGEEASDKNGALLGDSVVRTIQTGIRAQFANSGSNSAFKTMAEIGITQDG TSGKLKIDDDKLTKVLKDNTAAARELLVGDGKETGITKIATEVKSYLADDGIIDNAQDNVNATLKSLTKQYLSVSNSIDETVARYKAQFTQLDTMMSKLNNTSSYLTQQFTAMNKS (SEQ ID NO: 33)

[0198] fliC, WP_000079805.1

[0199] >WP_000079805.1 Multitype: FliC / FljB series flagella [Salmonella]

[0200] MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEI DRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATTVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYE VSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKT EVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR (SEQ ID NO: 34)

[0201] fljB, WP_000079794.1

[0202] >WP_000079794.1 Multitype: FliC / FljB series flagella [Salmonella]

[0203] MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRV SGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDSLNVQKAYDVKDTAVTTKAYANNGTTLDVSGLDDAAIKAATGGTNGTASVTGGAVKFDADNNKYFVTIGGFTGADAAKNGDY EVNVATDGTVTLAAGATKTTMPAGATTKTEVQELKDTPAVVSADAKNALIAGGVDATDANGAELVKMSYTDKNGKTIEGGYALKAGDKYYAADYDEATGAIKAKTTSYTAADGTTKTAANQLGGVD GKTEVVTIDGKTYNASKAAGGHDFKAQPELAEAAAKTTENPLQKIDAALAQVDALRSDLGAVQNRFNSAITNLGNTVNNLSEARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR (SEQ ID NO: 35)

[0204] flgN, WP_000197547.1

[0205] >WP_000197547.1 Multi-type: Flagellar biosynthetic chaperone FliJ [Salmonella]

[0206] MTRLSEILDQMTTVLNNDLKTVMDAEQQQLSVGQINGSQLQRITEEKSSLLATLDYLEQQRRLEQNAQRSANDDIAERWQAITEKTQHLRDLNQHNGWLLEGQIERNQQALEVLKPHQEPTLYGADGQTSVSHRGGKKISI (SEQ ID NO: 36)

[0207] flgM, WP_000020893.1

[0208] >WP_000020893.1 Multi-type: Anti-Sigma-28 Factor FlgM [Salmonella]

[0209] MSIDRTSPLKPVSTVQTRETSDTPVQKTRQEKTSAATSASVTLSDAQAKLMQPGVSDINMERVEALKTAIRNGELKMDTGKIADSLIREAQSYLQSK (SEQ ID NO: 37)

[0210] flgA, WP_001194082.1

[0211] >WP_001194082.1 Multivarie: Flagellar basal body P-ring forming protein FlgA [Salmonella]

[0212] MQTLKRGFAVAALLFSPLTMAQDINAQLTTWFSQRLAGFSDEVVVTLRSSPNLLPSCEQPAFSMTGSAKLWGNVNVVARCANEKRYLQVNVQATGNYVAVAAPIARGGK LTPANVTLKRGRLDQLPPRTVLDIRQIQDAVSLRDLAPGQPVQLTMIRQAWRVKAGQRVQVIANGEGFSVNAEGQAMNNAAVAQNARVRMTSGQIVSGTVDSDGNILINL (SEQ ID NO: 38)

[0213] flgB, WP_000887043.1

[0214] >WP_000887043.1 Multivarie: Flagellar basal body rod protein FlgB [Salmonella]

[0215] MLDRLDAALRFQQEALNLRAQRQEILAANIANADTPGYQARDIDFASELKKVMVRGREETGGVALTLTSSHIPAQAVSSPAVDLLYRVPDQPSLDGNTVDMDRERTQFADNSLKYQMGLTVLGSQLKGMMNVLQGGN (SEQ ID NO: 39)

[0216] flgC, WP_001196448.1

[0217] >WP_001196448.1 Multivarie: Flagellar basal body rod protein FlgC [Salmonella]

[0218] MALLNIFDIAGSALAAQSKRLNVAASNLANADSVTGPDGQPYRAKQVVFQVDAAPGQATGGVKVASVIESQAPEKLVYEPGNPLADANGYVKMPNVDVVGEMVNTMSASRSYQANIEVLNTVKSMMLKTLTLGQ (SEQ ID NO: 40)

[0219] flgD, WP_000020450.1

[0220] >WP_000020450.1 Multivarie: Flagellar hook assembly protein FlgD [Salmonella]

[0221] MSIAVNMNDPTNTGVKTTTGSGSMTGSNAADLQSSFTLTLVAQLKNQDPTNPLQNNELTTQLAQISTVSGIEKLNTTLGAISGQIDNSQSLQATTLIGHGVMVPGTTILAGKGAEE GAVTSTTPFGVELQQPADKVTATITDKDGRVVRTLEIGELRAGVHTFTWDGKQTDGTTVPNGSYNIAITASNGGTQLVAQPLQFALVQGVTKGSNGNLLDLGTYGTTTLDEVRQII (SEQ ID NO: 41)

[0222] flgE, WP_000010567.1

[0223] >WP_000010567.1 Multivarie: Flagellar hook protein FlgE [Salmonella]

[0224] MSFSQAVSGLNAAATNLDVIGNNIANSATYGFKSGTASFADMFAGSKVGLGVKVAGITQDFTDGTTTNTGRGLDVAISQNGFFRLVDSNGSVFYSRNGQF KLDENRNLVNMQGMQLTGYPATGTPPTIQQGANPAPITIPNTLMAAKSTTTASMQINLNSTDPVPSKTPFSVSDADSYNKKGTVTVYDSQGNAHDMNVYFV KTKDNEWAVYTHDSSDPAATAPTTASTTLKFNENGILESGGTVNITTGTINGATAATFSLSFLNSMQQNTGANNIVATNQNGYKPGDLVSYQINNDGTVVG NYSNEQEQVLGQIVLANFANNEGLASQGDNVWAATQASGVALLGTAGSGNFGKLTNGALEASNVDLSKELVNMIVAQRNYQSNAQTIKTQDQILNTLVNLR (SEQ ID NO: 42)

[0225] flgF, WP_000349278.1

[0226] >WP_000349278.1 Multivarie: Flagellar basal body rod protein FlgF [Salmonella]

[0227] MDHAIYTAMGAASQTLNQQAVTASNLANASTPGFRAQLNALRAVPVDGLSLATRTLVTASTPGADMTPGQLDYTSRPLDVALQQDGWLVVQAADGAEGYTRNGNIQVGPTGQLTIQGHPVIGEGG PITVPEGSEITIAADGTISALNPGDPPNTVAPVGRLKLVKAEGNEVQRSDDGLLFRLTAEAQAERGAVLAADPSIRIMSGVLEGSNVKPVEAMTDMIANARRFEMQMKVITSVDENEGRANQLLSMS (SEQ ID NO: 43)

[0228] flgG, WP_000625851.1

[0229] >WP_000625851.1 Multivarie: Flagellar basal body rod protein FlgG [Salmonella]

[0230] MISSLWIAKTGLDAQQTNMDVIANNLANVSTNGFKRQRAVFEDLLYQTIRQPGAQSSEQTTLPSGLQIGTGVRPVATERLHSQGNLSQTNNSKDVAIKGQGFFQVMLPDGTSAYTRDGSFQVDQNGQLVT AGGFQVQPAITIPANALSITIGRDGVVSVTQQGQAAPVQVGQLNLTTFMNDTGLESIGENLYIETQSSGAPNESTPGLNGAGLLYQGYVETSNVNVAEELVNMIQVQRAYEINSKAVSTTDQMLQKLTQL (SEQ ID NO: 44)

[0231] flgH, WP_001174897.1

[0232] >WP_001174897.1 Multivarie: Flagellar basal body L-ring protein FlgH [Salmonella]

[0233] MQKYALHAYPVMALMVATLTGCAWIPAKPLVQGATTAQPIPGPVPVANGSIFQSAQPINYGYQPLFEDRRPRNIGDTLTIVLQENVSASKSSSANASRDGKTSFGFDTVPRYLQGL FGNSRADMEASGGNSFNGKGGANASNTFSGTLTVTVDQVLANGNLHVVGEKQIAINQGTEFIRFSGVVNPRTISGSNSVPSTQVADARIEYVGNGYINEAQNMGWLQRFFLNLSPM (SEQ ID NO: 45)

[0234] flgI, WP_001518955.1

[0235] >WP_001518955.1 Multivarie: Flagellar basal body P-ring protein FlgI [Salmonella]

[0236] MFKALAGIVLALVATLAHAERIRDLTSVQGVRENSLIGYGLVVGLDGTGDQTTQTPFTTQTLNNMLSQLGITVPTGTNMQLKNVAAVMVTASYPPFARQGQTIDVVVSSMGNAKSLRGGTLLMTPLKGVDSQVYALAQGNILVGGAGASAGGSSVQVNQLNGGRITNGAIIERELPTQFGAG NTINLQLNDEDFTMAQQITDAINRARGYGSATALDARTVQVRVPSGNSSQVRFLADIQNMEVNVTPQDAKVVINSRTGSVVMNREVTLDSCAVAQGNLSVTVNRQLNVNQPNTPFGGGQTVVTPQTQIDLRQSGGSLQSVRSSANLNSVVRALNALGATPMDLMSILQSMQSAGCLRAKLEII (SEQ ID NO: 46)

[0237] flgJ, WP_000578692.1

[0238] >WP_000578692.1 Multi-type: Flagellar assembly peptidoglycan hydrolase FlgJ [Salmonella]

[0239] MIGDGKLLASAAWDAQSLNELKAKAGQDPAANIRPVARQVEGMFVQMMLKSMREALPKDGLFSSDQTRLYTSMYDQQIAQQMTAGKGLGLADMMVKQMTSGQTMPADDAPQVPLKFSLETVNSYQNQALTQLVRKAIPKTPDSSDAPLSGDSKDFLAR LSLPARLASEQSGVPHHLILAQAALESGWGQRQILRENGEPSYNVFGVKATASWKGPVTEITTTEYENGEAKKVKAKFRVYSSYLEALSDYVALLTRNPRYAAVTTAATAEQGAVALQNAGYATDPNYARKLTSMIQQLKAMSEKVSKTYSANLDNLF (SEQ ID NO: 47)

[0240] flgK, WP_000096425.1

[0241] >WP_000096425.1 Multivarie: Flagellar hook-associated protein FlgK [Salmonella]

[0242] MSSLINHAMSGLNAAQAALNTVSNNINNYNVAGYTRQTTILAQANSTLGAGGWIGNGVYVSGVQREYDAFITNQLRGAQNQSSGLTTRYEQMSKIDNLLADKSSSLSGSLQSFFTSLQTLVSNAEDPAARQALIGKAE GLVNQFKTTDQYLRDQDKQVNIAIGSSVAQINNYAKQIANLNDQISRMTGVGAGASPNDLLDQRDQLVSELNKIVGVEVSVQDGGTYNLTMANGYTLVQGSTARQLAAVPSSADPTRTTVAYVDEAAGNIEIPEKLLN TGSLGGLLTFRSQDLDQTRNTLGQLALAFADAFNAQHTKGYDADGNKGKDFFSIGSPVVYSNSNNADKTVSLTAKVVDSTKVQATDYKIVFDGTDWQVTRTADNTTFTATKDADGKLEIDGLKVTVGTGAQKNDSFLL KPVSNAIVDMNVKVTNEAEIAMASESKLDPDVDTGDSDNRNGQALLDLQNSNVVGGNKTFNDAYATLVSDVGNKTSTLKTSSTTQANVVKQLYKQQQSVSGVNLDEEYGNLQRYQQYYLANAQVLQTANALFDALLNIR (SEQ ID NO: 48)

[0243] flgL WP_001223033.1

[0244] >WP_001223033.1 Multivarie: Flagellar hook-associated protein FlgL [Salmonella]

[0245] MRISTQMMYEQNMSGITNSQAEWMKLGEQMSTGKRVTNPSDDPIAASQAVVLSQAQAQNSQYALARTFATQKVSLEESVLSQVTTAIQTAQEKIVYAGNGTLSDDDRASLATDLQGIRDQLMNLANSTDGNGRYIFAGYKTEAAPFDQATGGYHGGEK SVTQQVDSARTMVIGHTGAQIFNSITSNAVPEPDGSDSEKNLFVMLDTAIAALKTPVEGNNVEKEKAAAAIDKTNRGLKNSLNNVLTVRAELGTQLSELSTLDSLGSDRALGQKLQMSNLVDVDWNSVISSYVMQQAALQASYKTFTDMQGMSLFQLNR (SEQ ID NO: 49)

[0246] II. Vector / Plasmid

[0247] In the composition and / or method, DNA, RNA (e.g., nucleic acid-based gene interfering agent), or protein may be produced by a recombinant method. The nucleic acid is inserted into a replicatable vector for expression. Many such vectors are available. Vector components generally include, but are not limited to, a replication origin, one or more marker genes, an enhancer element, a promoter, and one or more of a transcription termination sequence and a coding sequence. In some embodiments, for example, when using a bacterial delivery agent such as Salmonella, the gene and / or promoter (sequence of interest) may be incorporated into the host cell chromosome or, for example, presented on a plasmid / vector.

[0248] Expression vectors generally contain selection genes, which are also called selection markers. These genes encode proteins necessary for the survival or growth of transformed host cells grown in a selective culture medium. Host cells not transformed with a vector containing a selection gene will not survive in the culture medium. Common selection genes encode proteins that (a) confer resistance to antibiotics or other toxins, e.g., ampicillin, neomycin, methotrexate, or tetracycline, (b) compensate for nutritional deficiencies, or (c) supply important nutrients that are not available from the complex medium.

[0249] Expression vectors may contain promoters that are recognized by the host organism and operably linked to nucleic acid sequences, such as the nucleic acid sequence encoding an open translation frame. Promoters are untranslated sequences located upstream (5') of the start codon of a structural gene that regulates the transcription of the specific nucleic acid sequence to which they are operably linked (typically within about 100 to 1000 bp). In bacterial cells, the region regulating the entire regulation may be referred to as an operator. Promoters are generally divided into two classes: inducible and constitutive. Inducible promoters are promoters that initiate increased transcription levels from DNA under their control in response to some change in culture conditions, e.g., the presence or absence of nutrients or changes in temperature. A number of promoters recognized by various potential host cells are well known.

[0250] Promoters suitable for use with prokaryotic hosts include β-lactamase and lactose promoter systems, alkaline phosphatase, tryptophan (trp) promoter systems, hybrid promoters such as tac promoters, and starvation promoters (Matin, A. (1994) Recombinant DNA Technology II, Annals of New York Academy of Science, 722:277-291). However, other known bacterial promoters are also suitable. Since these nucleotide sequences are disclosed, a skilled user can operably link them to a DNA coding sequence. Promoters for use in bacterial systems may also contain a Shine-Dalgarno (SD) sequence operably linked to a coding sequence.

[0251] The construction of a suitable vector containing one or more of the components listed above uses standard binding techniques. The isolated plasmid or DNA fragment is cleaved into the desired form, fitted, and recombined to generate the required plasmid.

[0252] In some embodiments of the present invention, the expression vector is a plasmid or bacteriophage vector suitable for use with Salmonella, and DNA, RNA and / or protein is provided to a subject through expression by engineered Salmonella (attenuated in one embodiment) administered to the patient. As used herein, the term “plasmid” refers to any nucleic acid encoding an expressible gene and includes linear or circular nucleic acids and double or single-stranded nucleic acids. The nucleic acid may be DNA or RNA, may include modified nucleotides or ribonucleotides, and may be chemically modified by means such as methylation or the inclusion of a protecting group or a cap- or tail structure.

[0253] One embodiment provides a Salmonella strain comprising a lysed gene or cassette operably linked to an intracellularly induced Salmonella promoter. In one embodiment, the promoter is SpiC / SsaB (registration number CBW17423.1), SseF (registration number CBW17434.1), SseG (registration number CBW17435.1), SseI (registration number CBW17087.1), SseJ (registration number CBW17656.1 or NC_016856.1), SseK1 (registration number CBW20184.1), SseK2 (registration number CBW18209.1), SifA (registration number CBW17257.1), SifB (registration number CBW17627.1), PipB (registration number CBW17123.1), PipB (registration number CBW18862.1), SopD2 (registration number CBW17005.1), GogB (registration number CBW18646.2), SseL (registration number It is a promoter for one of the genes of the Salmonella pathogenic islet type III secretion system (SPI2-T3SS) selected from the group CBW18358.1), SteC (registration number CBW17723.1), SspH1 (registration number STM14_1483), SspH2 (registration number CBW18313.1), or SirP (examples / exemplaries of sequences that may be used in the composition / method of the present invention are provided by the registration numbers and sequences provided throughout this specification, and other sequences including sequences having about 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% and 100% or more identity may also be used in the composition / method of the present invention).

[0254] SpiC / SsaB (Registration No. CBW17423.1):

[0255] 1 mseegfmlav lkgipliqdi raegnsrswi mtidghparg eifseafsis lflndleslp

[0256] 61 kpclayvtll laahpdvhdy aiqltadggw lngyyttsss seliaieiek hlaltcilkn

[0257] 121 virnhhklys ggv (sequence number 50)

[0258] SseF (Registration number CBW17434.1):

[0259] 1 mkihipsaas nivdgnspps diqakevsfp ppeipapgtp aapvlltpeq irqqrdyaih

[0260] 61 fmqytiralg atvvfglsva aavisggagl piailagaal viaigdacca yhnyqsicqq

[0261] 121 keplqtasds valvvsalal kcgaslncan tlanclslli rsgiaismlv lplqfplpaa

[0262] 181 eniaasldmg svitsvslta igavldycla rpsgddqens vdelhadpsv llaeqmaalc

[0263] 241 qsattpalmd ssdhtsrgep (sequence number 51)

[0264] SseG(Registration number CBW17435.1):

[0265] 1 mkpvspnaqv ggqrpvnape esppcpslph petnmesgri gpqqgkervl aglakrviec

[0266] 61 fpkeifswqt vilggqilcc sagialtvls gggaplvala giglaiaiad vacliyhhkh

[0267] 121 hlpmahdsig navfyiancf anqrksmaia kavslggrla ltatvmthsy wsgslglqph

[0268] 181 llerlndity glmsftrfgm dgmamtgmqv ssplyrllaq vtpeqrape (sequence number 52)

[0269] SseI(Registration number CBW17087.1):

[0270] 1 mpfhigsgcl paiisnrriy riawsdtppe msswekmkef fcsthqaeal eciwtichpp

[0271] 61 agttredvvs rfellrtlay dgweenihsg lhgenyfcil dedsqeilsv tlddvgnytv

[0272] 121 ncqgysethh ltmatepgve rtditynlts didaaaylee lkqnpiinnk imnpvgqces

[0273] 181 lmtpvsnfmn ekgfdniryr gifiwdkpte eiptnhfavv gnkegkdyvf dvsahqfenr

[0274] 241 gmsnlngpli lsadewvcky rmatrrkliy ytdfsnssia anaydalpre lesesmagkv

[0275] 301 fvtsprwfnt fkkqkyslig km (Registration No.: 53)

[0276] SseL(Registration number CBW17656.1):

[0277] 1 mplsvgqgyf tssissekfn aikesarlpe lslwekikay fftthhaeal ecifnlyhhq

[0278] 61 elnltpvqvr gayiklrala sqgckeqfii esqehadkli ikddngenil sievechpea

[0279] 121 fglakeinks hpkpknislg ditrlvffgd slsdslgrmf ekthilpsy gqyfggrftn

[0280] 181 gftwteflss phflgkemln faeggstsas yscfncigdf vsntdrqvas ytpshqdlai

[0281] 241 fllgandymt lhkdnvimvv eqqiddieki isggvnnvlv mgipdlsltp ygkhsdekrk

[0282] 301 lkdesiahna llktnveelk ekypqhkicy yetadafkvi meaasnigyd tenpythhgy

[0283] 361 vhvpgakdpq ldicpqyvfn dlvhptqevh hcfaimlesf iahhyste (Registration No.: 54)

[0284] sseJ Sequence (DNA) - Registration Number - NCBI Reference Sequence: NC_016856.1

[0285]

[0286] sseJ 서열 (단백질)

[0287] MPLSVGQGYFTSSISSEKFNAIKESARLPELSLWEKIKAYFFTTHHAEALECIFNLYHHQELNLTPVQVRGAYIKLRALASQGCKEQFIIESQEHADKLIIKDDNGENILSIEVECHPEAFGLAKEINKSHPKPKNISLGDITRLVFFGDSLSDSLGRMFEKTHHILPSYGQYFGGRFTNGFTWTEFLSSPHFLGKEMLNFAEGGSTSASYSCFNCIGDFVSNTDRQVASYTPSHQDLAIFLLGANDYMTLHKDNVIMVVEQQIDDIEKIISGGVNNVLVMGIPDLSLTPYGKHSDEKRKLKDESIAHNALLKTNVEELKEKYPQHKICYYETADAFKVIMEAASNIGYDTENPYTHHGYVHVPGAKDPQLDICPQYVFNDLVHPTQEVHHCFAIMLESFIAHHYSTE (서열번호 56)

[0288] SseK1 (등록 번호 CBW20184.1):

[0289] 1 mipplnryvp alsknelvkt vtnrdiqfts fngkdyplcf ldektpllfq wfernparfg

[0290] 61 kndipiinte knpylnniik aatiekerli gifvdgdffp gqkdafskle ydyenikviy

[0291] 121 rndidfsmyd kklseiymen iskqesmpee krdchllqll kkelsdiqeg ndsliksyll

[0292] 181 dkghgwfdfy rnmamlkagq lfleadkvgc ydlstnsgci yldadmiite klggiyipdg

[0293] 241 iavhveridg rasmengiia vdrnnhpall agleimhtkf dadpysdgvc ngirkhfnys

[0294] 301 lnedynsfcd fiefkhdnii mntsqftqss warhvq (sequence number 57)

[0295] SseK2 (Registration number CBW18209.1):

[0296] 1 marfnaaftr ikimfsrirg liscqsntqt iaptlsppss ghvsfagidy pllplnhqtp

[0297] 61 lvfqwfernp drfgqneipi intqknpyln niinaaiiek eriigifvdg dfskgqrkal

[0298] 121 gkleqnyrni kviynsdlny smydkkltti ylenitklea qsaserdevl lngvkksled

[0299] 181 vlknnpeetl isshnkdkgh lwfdfyrnlf llkgsdafle agkpgchhlq pgggciylda

[0300] 241 dmlltdklgt lylpdgiaih vsrkdnhvsl engiiavnrs ehpalikgle imhskpygdp

[0301] 301 yndwlskglr hyfdgshiqd ydafcdfief kheniimts sltasswr (sequence number 58)

[0302] SifA (Registration No. CBW17257.1) :

[0303] 1 mpitingfl kseiltnspr ntkeawwkvl wekikdfffs tgkakadrcl hemlfaerap

[0304] 61 trerlteiff elkelacasq rdrfqvhnph endatiilri mdqneenell ritqntdtfs

[0305] 121 cevmgnlyfl mkdrpdilks hpqmtamikr ryseivdypl pstlclnpag apilsvpldn

[0306] 181 iegylytelr kghldgwkaq ekatylaaki qsgiekttri lhhanisest qqnafletma

[0307] 241 mcglkqleip pphthipiek mvkevlladk tfqaflvtdp stsqsmlaei veaisdqvfh

[0308] 301 aifridpqai qkmaeeqltt lhvrseqqsg clccfl (서열 번호 59)

[0309] SifB(등록 번호 CBW17627.1):

[0310] 1 mpitigrgfl ksemfsqsai sqrsfftllw ekikdffcdt qrstadqyik elcdvasppd

[0311] 61 aqrlfdlfck lyelsspscr gnfhfqhykd aecqytnlci kdgediplci mirqdhyyye

[0312] 121 imnrtvlcvd tqsahlkrys dinikastyv ceplcclfpe rlqlslsggi tfsvdlknie

[0313] 181 etliamaekg nlcdwkeqer kaaissrinl giaqagvtai ddaiknkiaa kvientnlkn

[0314] 241 aafepnyaqs svtqivyscl fkneilmnml eessshgllc lnelteyvtl qvhnslfsed

[0315] 301 lsslvettkn eahhqs (sequence number 60)

[0316] PipB (Registration number CBW17123.1) :

[0317] 1 mpitnaspen ilrylhaagt gtkeamksat sprgilewfv nfftcggvrr snerwfrevi

[0318] 61 gklttsllyv nknaffdgnk ifledvngct iclscgaase ntdpmviiev nkngktvtdk

[0319] 121 vdserfwnvc rmlklmskhn iqqpdslite dgflnlrgvn lahkdfqged lskidasnad

[0320] 181 frettlsnvn lvganlccan lhavnlmgsn mtkanlthad ltcanmsgvn ltaailfgsd

[0321] 241 ltdtklngak ldkialtlak altgadltgs qhtptplpdy ndrtlfphpi f (Sequence number: 61)

[0322] PipB2 (Registration number CBW18862.1) :

[0323] 1 mersldslag maksafgagt saamrqatsp ktileyiinf ftcggirrrn etqyqeliet

[0324] 61 maetlkstmp drgaplpeni ilddmdgcrv efnlpgenne agqvivrvsk gdhsetreip

[0325] 121 lasfekicra llfrcefslp qdsviltaqg gmnlkgavlt ganltsenlc dadlsganle

[0326] 181 gavlfmadce ganfkganls gtslgdsnfk nacledsimc gatldhanlt ganlqhasll

[0327] 241 gcsmiecncs ganmdhtnls gatliradms gatlqgatim aaimegavlt ranlrkasfi

[0328] 301 stnldgadla eanlnntcfk dctltdlrte datmststqt lfnefyseni (서열 번호 62)

[0329] SopD2 (등록 번호 CBW17005.1):

[0330] 1 mpvtlsfgnr hnyeinhsrl arlmspdkee alymgvwdrf kdcfrthkkq evlevlytli

[0331] 61 hgcerenqae lnvditgmek ihaftqlkey anpsqqdrfv mrfdmnqtqv lfeidgkvid

[0332] 121 kcnlhrllnv sencifkvme edeeelflki cikygekisr ypellegfan klkdavnedd

[0333] 181 dvkdevyklm rsgedrkmec vewngtltee eknklrclqm gsfnittqff kigywelege

[0334] 241 vlfdmvhptl syllqaykps lssdlietnt mlfsdvlnkd yddyqnnkre idailrriyr

[0335] 301 shnntlfise ksscrnmli (서열 번호 63)

[0336] GogB (등록 번호 CBW18646.2):

[0337] 1 mqyaytsnea tsnlellnkw riespdieke ernsiydkii eanhtgslsi tahhvtsipv

[0338] 61 fpdnlselnl sscytlesip nlpdglkslt isgnqtikis yfpdslesls idmqayeeny

[0339] 121 tfpalpyglk sftacygkfl pplpphlssl slqnfseilc aelpykldkl dlqncpflpl

[0340] 181 mkmlpeelke lsielirtvp gtviddilpd klkklsinfc dniklpvklp vnlksinlss

[0341] 241 rtpiaweipt cnlpahidis tdgyvklnpe fltrsditfs nkpagdvlsf qpgdvvyglc

[0342] 301 cardrvntlv nslyyfskkd iiiqntltda vwdrknravf nkdekiaerl ndvqrgiffr

[0343] 361 eflsqhkkyn itedkysdls neecwiktsk aglefqtrlr ersvifvidn lvdaisdian

[0344] 421 ktgkhgnsit ahelrwvyrn rhddlvkqnv kfflngeais hedvfslvgw dkykpknrnr (서열 번호 64)

[0345] SseL(등록 번호 CBW18358.1):

[0346] 1 msdealtllf savengdqnc idllcnlalr nddlghrvek flfdlfsgkr tgssdidkki

[0347] 61 nqaclvlhqi annditkdnt ewkklhapsr llymagsatt dlskkigiah kimgdqfaqt

[0348] 121 dqeqvgvenl wcgarmlssd elaaatqglv qespllsvny piglihpttk enilstqlle

[0349] 181 kiaqsglshn evflvntgdh wllclfykla ekikclifnt yydlnentkq eiieaakiag

[0350] 241 isesdevnfi emnlqnnvpn gcglfcyhti qllsnagqnd pattlrefae nfltlsveeq

[0351] 301 alfntqtrrq iyeyslq (서열 번호 65)

[0352] SteC(등록 번호 CBW17723.1):

[0353] 1 mpftfqignh scqiserylr diidnkrehv fstcekfidf frniftrrsl isdyreiynl

[0354] 61 lcqkkehpdi kgpfspgpfs krdedctrwr pllgyiklid asrpetidky tvevlahqen

[0355] 121 mlllqmfydg vlvtetecse rcvdflketm fnynngeitl aalgndnlpp seagsngiye

[0356] 181 afeqrlidfl ttpatasgye sgaidqtdas qpaaieafin spefqknirm rdieknkigs

[0357] 241 gsygtvyrlh ddfvvkipvn ergikvdvns pehrnchpdr vskylnmand dknfsrsaim

[0358] 301 ningkdvtvl vskyiqgqef dvedednyrm aeallksrgv ymhdinilgn ilvkegvlff

[0359] 361 vdgdqivlsq esrqqrsvsl atrqleeqik ahhmiklkra etegntedve yykslitdld

[0360] 421 aligeeeqtp apgrrfklaa peegtlvakv lkdelkk (서열번호 66)

[0361] SspH1 (등록 번호 STM14_1483):

[0362] 1 mfnirntqps vsmqaiagaa apeaspeeiv wekiqvffpq enyeeaqqcl aelchpargm

[0363] 61 lpdhissqfa rlkaltfpaw eeniqcnrdg inqfcildag skeilsitld dagnytvncq

[0364] 121 gyseahdfim dtepgecte faegasgtsl rpattvsqka aeydavwskw erdapagesp

[0365] 181 graavvqemr dclnngnpvl nvgasglttl pdrlpphitt lvipdnnlts lpelpeglre

[0366] 241 levsgnlqlt slpslpqglq klwaynnwla slptlppglg dlavsnnqlt slpemppalr

[0367] 301 elrvsgnnlt slpalpsglq klwaynnrlt slpemspglq eldvshnqlt rlpqsltgls

[0368] 361 saarvyldgn plsvrtlqal rdiighsgir ihfdmagpsv prearalhla vadwltsare

[0369] 421 geaaqadrwq afglednaaa fslvldrlre tenfkkdagf kaqisswltq laedaalrak

[0370] 481 tfamateats tcedrvthal hqmnnvqlvh naekgeydnn lqglvstgre mfrlatleqi

[0371] 541 arekagtlal vddvevylaf qnklkeslel tsvtsemrff dvsgvtvsdl qaaelqvkta

[0372] 601 ensgfskwil qwgplhsvle rkvperfnal rekqisdyed tyrklydevl kssglvddtd

[0373] 661 aertigvsam dsakkefldg lralvdevlg syltarwrln (서열번호 67)

[0374] SspH2 (등록 번호 CBW18313.1):

[0375] 1 mpfhigsgcl patisnrriy riawsdtppe msswekmkef fcsthqteal eciwtichpp

[0376] 61 agttredvin rfellrtlay agweesihsg qhgenyfcil dedsqeilsv tlddagnytv

[0377] 121 ncqgysethr ltldtaqgee gtghaegasg tfrtsflpat tapqtpaeyd avwsawrraa

[0378] 181 paeesrgraa vvqkmracln ngnavlnvge sglttlpdcl pahittlvip dnnltslpal

[0379] 241 ppelrtlevs gnqltslpvl ppgllelsif snplthlpal psglcklwif gnqltslpvl

[0380] 301 ppglqelsvs dnqlaslpal pselcklway nnqltslpml psglqelsvs dnqlaslptl

[0381] 361 pselyklway nnrltslpal psglkelivs gnrltslpvl pselkelmvs gnrltslpml

[0382] 421 psgllslsvy rnqltrlpes lihlssettv nlegnplser tlqalreits apgysgpiir

[0383] 481 fdmagasapr etralhlaaa dwlvparege papadrwhmf gqednadafs lfldrlsete

[0384] 541 nfikdagfka qisswlaqla edealrantf amateatssc edrvtfflhq mknvqlvhna

[0385] 601 ekgqydndla alvatgremf rlgkleqiar ekvrtlalvd eievwlayqn klkkslglts

[0386] 661 vtsemrffdv sgvtvtdlqd aelqvkaaek sefrewilqw gplhrvlerk apervnalre

[0387] 721 kqisdyeety rmlsdtelrp sglvgntdae rtigarames akktfldglr plveemlgsy

[0388] 781 lnvqwrrn (서열번호 68)

[0389] In one embodiment, the Salmonella genes under the control of an inducible promoter are ftsW (Registration No. CBW16230.1), ftsA (Registration No. CBW16235.1), ftsZ (Registration No. CBW16236.1), murE (Registration No. CBW16226.1), mukF (Registration No. CBW17025.1), imp (Registration No. CBW16196.1), secF (Registration No. CBW16503.1), eno (Registration No. CBW19030.1), hemH (Registration No. CBW16582.1), tmk (Registration No. CBW17233.1), dxs (Registration No. CBW16516.1), uppS (Registration No. CBW16324.1), cdsA (Registration No. CBW16325.1), accA (Registration No. It is selected from CBW16335.1), pssA (registration number CBW18718.1), msbA (registration number CBW17017.1), tsf (registration number CBW16320.1), trmD (registration number CBW18749.1), cca (registration number CBW19276.1), infB (registration number CBW19355.1), rpoA (registration number CBW19477.1), rpoB (registration number CBW20180.1), rpoC (registration number CBW20181.1), holA (registration number CBW16734.1), dnaC (registration number CBW20563.1), or eng(EngA registration number CBW18582.1; EngB registration number CBW20039.1).

[0390] ftsW (Registration number CBW16230.1):

[0391] 1 mmasrdkdad slimydrtll wltfglaaig fvmvtsasmp vgqrlandpf lfakrdalyi

[0392] 61 flafclamvt lrlpmtfwqk ysttmliasi imllivlvvg ssvngasrwi algplriqpa

[0393] 121 eftklslfcy lanylvrkvd evrnnlrgfl kpmgvilvla vlllaqpdlg tvvvlfvttl

[0394] 181 amlflagakl wqfiaiigmg isavillila epyrirrvts fwnpwedpfg sgyqltqslm

[0395] 241 afgrgeiwgq glgnsvqkle ylpeahtdfi faiigeelgy igvvlallmv ffvaframsi

[0396] 301 grkaleidhr fsgflacsig iwfsfqalvn vgaaagmlpt kgltlplisy ggssllimst

[0397] 361 aimfllridy etrlekaqaf trgsr (서열번호 69)

[0398] ftsW (등록 번호 CBW16235.1):

[0399] 1 mikatdrklv vgleigtakv aalvgevlpd gmvniigvgs cpsrgmdkgg vndlesvvkc

[0400] 61 vqraidqael madcqissvy lalsgkhisc qneigmvpis eeevtqedve nvvhtaksvr

[0401] 121 vrdehrvlhv ipqeyaidyq egiknpvgls gvrmqakvhl itchndmakn ivkavercgl

[0402] 181 kvdqlifagl aasysvlted erelgvcvvd igggtmdiav ytggalrhtk vipyagnvvt

[0403] 241 sdiayafgtp psdaeaikvr hgcalgsivg kdesvevpsv ggrpprslqr qtlaeviepr

[0404] 301 ytellnlvne eilqlqeqlr qqgvkhhlaa givltggaaq ieglaacaqr vfhtqvriga

[0405] 361 plnitgltdy aqepyystav gllhygkesh lngeaevekr vtasvgswik rlnswlrkef (sequence number 70)

[0406] ftsZ (Registration number CBW16236.1):

[0407] 1 mfepmeltnd avikvigvgg gggnavehmv reriegveff avntdaqalr ktavgqtiqi

[0408] 61 gsgitkglga ganpevgrna adedrealra alegadmvfi aagmgggtgt gaapvvaeva

[0409] 121 kdlgiltvav vtkpfnfegk krmafaeqgi telskhvdsl itipndkllk vlgrgislld

[0410] 181 afgaandvlk gavqgiaeli trpglmnvdf advrtvmsem gyammgsgva sgedraeeaa

[0411] 241 emaissplle didlsgargv lvnitagfdl rldefetvgn tirafasdna tvvigtsldp

[0412] 301 dmndelrvtv vatgigmdkr peitlvtnkq vqqpvldryq qhgmapltqe qktvakvvnd

[0413] 361 ntpqaakepd yldipaflrk qad (sequence number 71)

[0414] murE (Registration number CBW16226.1):

[0415] 1 madrnlrdll apwvaglpar elremtldsr vaaagdlfva vvghqadgrr yipqaiaqgv

[0416] 61 aaiiaeakde asdgeiremh gvpvvylsql nerlsalagr fyhepsenmr lvavtgtngk

[0417] 121 ttttqllaqw sqllgetsav mgtvgngllg kviptenttg savdvqhvla slvaqgatfg

[0418] 181 amevsshglv qhrvaalkfa asvftnlsrd hldyhgdmah yeaakwmlys thhhgqaivn

[0419] 241 addevgrrwl aslpdavavs meghinpnch grwlkaeave yhdrgatirf asswgegeie

[0420] 301 srlmgafnvs nlllalatll algypltdll ktaarlqpvc grmevftapg kptvvvdyah

[0421] 361 tpdalekalq aarlhcagkl wcvfgcggdr dkgkrplmga iaeefadivv vtddnprtee

[0422] 421 praiindila gmldagqvrv megraeavtn aimqakdndv vliagkghed yqivgtqrld

[0423] 481 ysdrvtaarl lgvia (서열 번호 72)

[0424] mukF (등록 번호 CBW17025.1):

[0425] 1 msefsqtvpe lvawarkndf sislpvdrls fllavatlng erldgemseg elvdafrhvs

[0426] 61 dafeqtseti gvrannaind mvrqrllnrf tseqaegnai yrltplgigi tdyyirqref

[0427] 121 stlrlsmqls ivagelkraa daaaeggdef hwhrnvyapl kysvaeifds idltqrimde

[0428] 181 qqqqvkddia qllnkdwraa isscelllse tsgtlrelqd tleaagdklq anllriqdat

[0429] 241 mthddlhfvd rlvfdlqskl driiswgqqs idlwigydrh vhkfirtaid mdknrvfaqr

[0430] 301 lrqsvqtyfd dpwaltyana drlldmrdee malrddevtg elppdleyee fneireqlaa

[0431] 361 iieeqlaiyk trqtpldlgl vvreylaqyp rarhfdvari vidqavrlgv aqadftglpa

[0432] 421 kwqpindyga kvqahvidky (Sequence No. 73)

[0433] imp (Registration number CBW16196.1):

[0434] 1 mkkriptlla tmiasalysh qglaadlasq cmlgvpsydr plvkgdtndl pvtinadnak

[0435] 61 gnypddavft gnvdimqgns rlqadevqlh qkqaegqpep vrtvdalgnv hyddnqvilk

[0436] 121 gpkgwanlnt kdtnvwegdy qmvgrqgrgk adlmkqrgen rytilengsf tsclpgsdtw

[0437] 181 svvgsevihd reeqvaeiwn arfkvgpvpi fyspylqlpv gdkrrsgfli pnakyttkny

[0438] 241 fefylpyywn iapnmdatit phymhrrgni mwenefrylt qagegvmeld ylpsdkvyed

[0439] 301 dhpkegdkhr wlfnwqhsgv mdqvwrfnvd ytkvsdssyf ndfdskygss tdgyatqkfs

[0440] 361 vgyavqnfda tvstkqfqvf ndqntssysa epqldvnyyh ndlgpfdtri ygqavhfvnt

[0441] 421 kdnmpeatrv hleptinlpl snrwgslnte aklmathyqq tnldsynsdp nnknkledsv

[0442] 481 nrvmpqfkvd gkliferdma mlapgytqtl eprvqylyvp yrdqsgiyny dssllqsdyn

[0443] 541 glfrdrtygg ldriasanqv ttgvttriyd daaverfnvs vgqiyyftes rtgddnikwe

[0444] 601 nddktgslvw agdtywrise rwglrsgvqy dtrldsvats sssleyrrdq drlvqlnyry

[0445] 661 aspeyiqatl psyystaeqy knginqvgav aswpiadrws ivgayyfdtn sskpadqmlg

[0446] 721 lqynsccyai rvgyerklng wdndkqhaiy dnaigfniel rglssnyglg tqemlrsnil

[0447] 781 pyqssm (서열 번호 74)

[0448] secF (등록 번호 CBW16503.1):

[0449] 1 maqeytveql nhgrkvydfm rwdfwafgis gllliaaivi mgvrgfnwgl dftggtviei

[0450] 61 tlekpaemdv mrealqkagy eepqlqnfgs shdimvrmpp tegetggqvl gskvvtiine

[0451] 121 atnqnaavkr iefvgpsvga dlaqtgamal lvalisilvy vgfrfewrla agvvialahd

[0452] 181 viitlgilsl fhieidltiv aslmsvigys lndsivvsdr irenfrkirr gtpyeifnvs

[0453] 241 ltqtlhrtli tsgttlvvil mlylfggpvl egfsltmlig vsigtassiy vasalalklg

[0454] 301 mkrehmlqqk vekegadqps ilp (sequence number 75)

[0455] eno (Registration number CBW19030.1):

[0456] 1 mskivkvigr eiidsrgnpt veaevhlegg fvgmaaapsg astgsreale lrdgdksrfl

[0457] 61 gkgvtkavga vngpiaqail gkdakdqagi dkimidldgt enksnfgana ilavslanak

[0458] 121 aaaaakgmpl yehiaelngt pgkysmpvpm mniinggeha dnnvdiqefm iqpvgaktvk

[0459] 181 eairmgsevf hhlakvlkgk gmntavgdeg gyapnlgsna ealaviaeav kaagyelgkd

[0460] 241 itlamdcaas efykdgkyvl agegnkafts eefthfleel tkqypivsie dgldesdwdg

[0461] 301 fayqtkvlgd kiqlvgddlf vtntkilkeg iekgiansil ikfnqigslt etlaaikmak

[0462] 361 dagytavish rsgetedati adlavgtaag qiktgsmsrs drvakynqli rieealgeka

[0463] 421 pyngrkeikg qa (sequence number 76)

[0464] hemH (Registration number CBW16582.1) :

[0465] 1 mrqtktgill anlgtpdapt peavkrylkq flsdrrvvdt prllwwpllr gvilplrspr

[0466] 61 vaklyqsiwm dggsplmvys reqqqalaar lpdtpvalgm sygspslesa vdellasdvd

[0467] 121 hivvlplypq yscstvgavw delgrilark rripgisfir dyaddgayid alaksaresf

[0468] 181 arhgepdvll lsyhgipqry adegddypqr crdttrelvs alglppekvm mtfqsrfgre

[0469] 241 pwltpytdet lkmlgekgtg hiqvmcpgfa adcletleei aeqnreifle aggkkyayip

[0470] 301 alnatpehid mmlkltapyr (sequence number 77)

[0471] tmk (Registration number CBW17233.1):

[0472] 1 mgsnyivieg legagkttar dvvvetleql girnmiftre pggtqlaekl rslvldirsv

[0473] 61 gdevitdkae vlmfyaarvq lvetvikpal aqgvwvigdr hdlstqayqg ggrgidqtml

[0474] 121 atlrdavlgd frpdltlyld vtpevglkra rargdldrie qesfdffnrt rarylelaaq

[0475] 181 dsrirtidat qpldavmrdi ratvtkwvqe qaa (서열 번호 78)

[0476] dxs (등록 번호 CBW16516.1):

[0477] 1 msfdiakypt lalvdstqel rllpkeslpk lcdelrryll dsvsrssghf asglgtvelt

[0478] 61 valhyvyntp fdqliwdvgh qayphkiltg rrdkigtirq kgglhpfpwr geseydvlsv

[0479] 121 ghsstsisag igiavaaeke gkdrrtvcvi gdgaitagma feamnhagdi rpdmlvilnd

[0480] 181 nemsisenvg alnnhlaqll sgklysslre ggkkvfsgvp pikellkrte ehikgmvvpg

[0481] 241 tlfeelgfny igpvdghdvm glistlknmr dlkgpqflhi mtkkgrgyep aekdpitfha

[0482] 301 vpkfdpssgc lpkssgglpg yskifgdwlc etaakdsklm aitpamregs gmvefsrkfp

[0483] 361 dryfdvaiae qhavtfaagl aiggykpvva iystflqray dqvihdvaiq klpvmfaidr

[0484] 421 agivgadgqt hqgafdlsyl rcipdmvimt psdenecrqm lftgyhyndg ptavryprgn

[0485] 481 aqgvaltple klpigkglvk rhgeklailn fgtlmpeaak vaealnatlv dmrfvkpldd

[0486] 541 tlilemaaqh dalvtleena imggagsgvn evlmahrkpv pvlniglpdf fipqgtqeea

[0487] 601 raelgldaag ieakikawla (sequence number 79)

[0488] uppS(Registration number CBW16324.1):

[0489] 1 mlsatqpvse nlpahgcrhv aiimdgngrw akkqgkiraf ghkagaksvr ravsfaanng

[0490] 61 idaltlyafs senwnrpaqe vsalmelfvw aldsevkslh rhnvrlriig disrfnsrlq

[0491] 121 erirksealt ahntgltlni aanyggrwdi vqgvrqlaeq vqagvlrpdq ideerlgqqi

[0492] 181 cmhelapvdl virtggehri snfllwqiay aelyftdvlw pdfdeqdfeg alhafanrer

[0493] 241 rfggtepgdd ka (sequence number 80)

[0494] cdsA (Registration number CBW16325.1):

[0495] 1 mlkyrlisaf vlipaviaal fllppvgfai itlvvcmlaa wewgqlsgfa arsqrvwlav

[0496] 61 lcglllalml fllpeyhhni rqplvemslw aslgwwvval llvlfypgsa aiwrnsktlr

[0497] 121 lifglltivp ffwgmlalra whydenhysg aiwllyvmil vwgadsgaym fgklfgkhkl

[0498] 181 apkvspgktw qgfigglata aviswgygmw anlnvapvil licsvvaala svlgdltesm

[0499] 241 fkreagikds ghlipghggi ldridsltaa vpvfacllll vfrtl (서열 번호 81)

[0500] acccA (등록 번호 CBW16335.1):

[0501] 1 mslnfldfeq piaeleakid sltavsrqde kldinideev hrlreksvel trkifadlga

[0502] 61 wqvaqlarhp qrpytldyvr lafdefdela gdrayaddka ivggiarleg rpvmiighqk

[0503] 121 gretkekirr nfgmpapegy rkalrlmema erfnmpiitf idtpgaypgv gaeergqsea

[0504] 181 iarnlremsr lnvpvictvi geggsggala igvgdkvnml qystysvisp egcasilwks

[0505] 241 adkaplaaea mgiiaprlke lklidsiipe plggahrnpe amaaslkaql ledladldvl

[0506] 301 stddlknrry qrlmsygya (sequence number 82)

[0507] pssA ( Registration number CBW18718.1):

[0508] 1 mlskfkrnkh qqhlaqlpki sqsvddvdff ytpatfretl lekiasatqr icivalyleq

[0509] 61 ddggkgilda lyaakrqrpe ldvrvlvdwh raqrgrigaa asntnadwyc rlaqenpgid

[0510] 121 vpvygvpint realgvlhfk gfiiddsvly sgaslndvyl hqhdkyrydr yqlirnrqma

[0511] 181 dimfdwvtqn lmngrgvnrl dntqrpkspe ikndirlyrq elrdasyhfq gdandeqlsv

[0512] 241 tplvglgkss llnktifhlm pcaehkltic tpyfnlpavl vrniiqllrd gkkveiivgd

[0513] 301 ktandfyipe depfkiigal pylyeinlrr flsrlqyyvn tdqlvvrlwk dddntyhlkg

[0514] 361 mwvddkwmll tgnnlnpraw rldlenaili hdpkqelapq rekelelirt httivkhyrd

[0515] 421 lqsiadypik vrklirrlrr iridrlisri l (Sequence No. 83)

[0516] msbA (Registration number CBW17017.1):

[0517] 1 mhndkdlstw qtfrrlwpti apfkagliva gialilnaas dtfmlsllkp llddgfgktd

[0518] 61 rsvllwmplv viglmilrgi tsyissycis wvsgkvvmtm rrrlfghmmg mpvaffdkqs

[0519] 121 tgtllsrity dseqvassss galitvvreg asiiglfimm fyyswqlsii lvvlapivsi

[0520] 181 airvvskrfr sisknmqntm gqvttsaeqm lkghkevlif ggqevetkrf dkvsnkmrlq

[0521] 241 gmkmvsassi sdpiiqlias lalafvlyaa sfpsvmdslt agtitvvfss mialmrplks

[0522] 301 ltnvnaqfqr gmaacqtlfa ildseqekde gkrvidratg dlefrnvtft ypgrevpalr

[0523] 361 ninlkipagk tvalvgrsgs gkstiaslit rfydideghi lmdghdlrey tlaslrnqva

[0524] 421 lvsqnvhlfn dtvanniaya rteeysreqi eeaarmayam dfinkmdngl dtiigengvl

[0525] 481 lsggqrqria iarallrdsp ilildeatsa ldteseraiq aaldelqknr tslviahrls

[0526] 541 tieqadeivv vedgiiverg thsellaqhg vyaqlhkmqf gq (서열 번호 84)

[0527] tsf (등록 번호 CBW16320.1):

[0528] 1 maeitaslvk elrertgagm mdckkaltea ngdielaien mrksgaikaa kkagnvaadg

[0529] 61 viktkidgnv afilevncqt dfvakdagfq afadkvldaa vagkitdvev lkaqfeeerv

[0530] 121 alvakigeni nirrvasleg dvlgsyqhga rigvlvaakg adeelvkqla mhvaaskpef

[0531] 181 vkpedvsadv vekeyqvqld iamqsgkpke iaekmvegrm kkftgevslt gqpfvmepsk

[0532] 241 svgqllkehn advtgfirfe vgegiekvet dfaaevaams kqs (sequence number 85)

[0533] trmD (Registration number CBW18749.1):

[0534] 1 mfigivslfp emfraitdyg vtgravkkgl lniqswsprd fahdrhrtvd drpygggpgm

[0535] 61 lmmvqplrda ihaakaaage gakviylspq grkldqagvs elatnqklil vcgryegvde

[0536] 121 rviqteidee wsigdyvlsg gelpamtlid svarfipgvl gheasaieds fadglldcph

[0537] 181 ytrpevlegm evppvllsgn haeirrwrlk qslgrtwlrr pellenlalt eeqarllaef

[0538] 241 ktehaqqqhk hdgma (sequence number 86)

[0539] cca (Registration number CBW19276.1):

[0540] 1 mkiylvggav rdallglpvk dkdwvvvgat pqemldagyq qvgrdfpvfl hpqtheeyal

[0541] 61 arterksgsg ytgftcyaap dvtleadlqr rdltinalar ddagqiidpy hgrrdlearl

[0542] 121 lrhvspafge dplrvlrvar faaryahlsf riadetlalm remtaagele hltpervwke

[0543] 181 tenalttrnp qvyfqvlrdc galrvlfpei dalfgvpapa kwhpeidtgv htlmtlsmaa

[0544] 241 mlspqldvrf atlchdlgkg ltpknlwprh hghgpagvkl veqlcqrlrv pndlrdlakl

[0545] 301 vaeyhdliht fpilqpktiv klfdaidawr kpqrveqial tseadvrgrt gfeasdypqg

[0546] 361 rwlreawqva qavptkevve agfkgieire eltkrriaav anwkekrcpn pas (서열 번호 87)

[0547] infB (등록 번호 CBW19355.1):

[0548] 1 mtdvtlkala aerqvsvdrl vqqfadagir ksaddsvsaq ekqtllahln reavsgpdkl

[0549] 61 tlqrktrstl nipgtggksk svqievrkkr tfvkrdpqea erlaaeeqaq reaeeqarre

[0550] 121 aeeqakreaq qkaereaaeq akreaaekak reaaekdkvs nqqtddmtkt aqaekarren

[0551] 181 eaaelkrkae eearrkleee arrvaeearr maeenkwtat pEBVedtsdy hvttsqharq

[0552] 241 aedendreve ggrgrgrnak aarpakkgkh aeskadreea raavrggkgg krkgsslqqg

[0553] 301 fqkpaqavnr dvvigetitv gelankmavk gsqvikammk lgamatinqv idqetaqlva

[0554] 361 eemghkvilr reneleeavm sdrdtgaaae prapvvtimg hvdhgktsll dyirstkvas

[0555] 421 geaggitqhi gayhvetdng mitfldtpgh aaftsmrarg aqatdivvlv vaaddgvmpq

[0556] 481 tieaiqhaka agvpvvvavn kidkpeadpd rvknelsqyg ilpeewgges qfvhvsakag

[0557] 541 tgidelldai llqaevlelk avrkgmasga viesfldkgr gpvatvlvre gtlhkgdivl

[0558] 601 cgfeygrvra mrnelgqevl eagpsipvei lglsgvpaag devtvvrdek karevalyrq

[0559] 661 gkfrevklar qqksklenmf anmtegevhe vnivlkadvq gsveaisdsl lklstdevkv

[0560] 721 kiigsgvggi tetdatlaaa snailvgfnv radasarkvi esesldlryy sviynlidev

[0561] 781 kaamsgmlsp elkqqiigla evrdvfkspk fgaiagcmvt egtikrhnpi rvlrdnvviy

[0562] 841 egeleslrrf kddvnevrng mecgigvkny ndvrvgdmie vfeiieiqrt ia (sequence number 88)

[0563] rpoA (Registration number CBW19477.1):

[0564] 1 mqgsvteflk prlvdieqvs sthakvtlep lergfghtlg nalrrillss mpgcavteve

[0565] 61 idgvlheyst kegvqedile illnlkglav rvqgkdevil tlnksgigpv taadithdgd

[0566] 121 veivkpqhvi chltdenasi smrikvqrgr gyvpastrih seederpigr llvdacyspv

[0567] 181 eriaynveaa rveqrtdldk lviemetngt idpeeairra atilaeqlea fvdlrdvrqp

[0568] 241 evkeekpefd pillrpvddl eltvrsancl kaeaihyigd lvqrtevell ktpnlgkksl

[0569] 301 teikdvlasr glslgmrlen wppasiade (sequence number 89)

[0570] rpoB (Registration number CBW20180.1):

[0571] 1 mvysytekkr irkdfgkrpq vldvpyllsi qldsfqkfie qdpegqygle aafrsvfpiq

[0572] 61 sysgnselqy vsyrlgEBVf dvqecqirgv tysaplrvkl rlviyereap egtvkdikeq

[0573] 121 evymgeiplm tdngtfving tervivsqlh rspgvffdsd kgkthssgkv lynariipyr

[0574] 181 gswldfefdp kdnlfvridr rrklpatiil ralnytteqi ldlffekvvf eirdnklqme

[0575] 241 liperlrget asfdieangk vyvekgrrit arhirqlekd dikhievpve yiagkvvskd

[0576] 301 yvdestgeli caanmelsld llaklsqsgh krietlftnd ldhgpyiset vrvdptndrl

[0577] 361 salveiyrmm rpgepptrea aeslfenlff sedrydlsav grmkfnrsll rdeiegsgil

[0578] 421 skddiidvmk klidirngkg evddidhlgn rrirsvgema enqfrvglvr veravkerls

[0579] 481 lgdldtlmpq dminakpisa avkeffgssq lsqfmdqnnp lseithkrri salgpggltr

[0580] 541 eragfevrdv hpthygrvcp ietpegpnig linslsvyaq tneygfletp yrrvvdgvvt

[0581] 601 deihylsaie egnyviaqan snlddeghfv edlvtcrskg esslfsrdqv dymdvstqqv

[0582] 661 vsvgaslipf lehddanral mganmqrqav ptlradkplv gtgmeravav dsgvtavakr

[0583] 721 ggtvqyvdas rivikvnede mypgeagidi ynltkytrsn qntcinqmpc vslgEBVerg

[0584] 781 dvladgpstd lgelalgqnm rvafmpwngy nfedsilvse rvvqedrftt ihiqelacvs

[0585] 841 rdtklgpeei tadipnvgea alskldesgi vyigaevtgg dilvgkvtpk getqltpeek

[0586] 901 llraifgeka sdvkdsslrv pngvsgtvid vqvftrdgve kdkraleiee mqlkqakkdl

[0587] 961 seelqileag lfsriravlv ssgveaekld klprdrwlel gltdeekqnq leqlaeqyde

[0588] 1021 lkhefekkle akrrkitqgd dlapgvlkiv kvylavkrri qpgdkmagrh gnkgviskin

[0589] 1081 piedmpyden gtpvdivlnp lgvpsrmnig qilethlgma akgigdkina mlkqqqevak

[0590] 1141 lrefiqrayd lgadvrqkvd lstfsddevl rlaenlrkgm piatpvfdga keaeikellk

[0591] 1201 lgdlptsgqi tlfdgrtgeq ferpvtvgym ymlklnhlvd dkmharstgs yslvtqqplg

[0592] 1261 gkaqfggqrf gemevwalea ygaaytlqem ltvksddvng rtkmyknivd gnhqmepgmp

[0593] 1321 esfnvllkei rslginiele de (서열 번호 90)

[0594] rpoC(등록 번호 CBW20181.1):

[0595] 1 mkdllkflka qtkteefdai kialaspdmi rswsfgevkk petinyrtfk perdglfcar

[0596] 61 ifgpvkdyec lcgkykrlkh rgvicekcgv evtqtkvrre rmghielasp tahiwflksl

[0597] 121 psrigllldm plrdiervly fesyvviegg mtnlerqqil teeqyldale efgdefdakm

[0598] 181 gaeaiqallk smdleqecet lreelnetns etkrkkltkr iklleafvqs gnkpewmilt

[0599] 241 vlpvlppdlr plvpldggrf atsdlndlyr rvinrnnrlk rlldlaapdi ivrnekrmlq

[0600] 301 eavdalldng rrgraitgsn krplksladm ikgkqgrfrq nllgkrvdys grsvitvgpy

[0601] 361 lrlhqcglpk kmalelfkpf iygklelrgl attikaakkm vereeavvwd ildevirehp

[0602] 421 vllnraptlh rlgiqafEBV liegkaiqlh plvcaaynad fdgdqmavhv pltleaqlea

[0603] 481 ralmmstnni lspangepii vpsqdvvlgl yymtrdcvna kgegmvltgp keaeriyrag

[0604] 541 laslharvkv riteyekden gefvahtslk dttvgrailw mivpkglpfs ivnqalgkka

[0605] 601 iskmlntcyr ilglkptvif adqtmytgfa yaarsgasvg iddmvipekk heiiseaeae

[0606] 661 vaeiqeqfqs glvtageryn kvidiwaaan drvskammdn lqtetvinrd gqeeqqvsfn

[0607] 721 siymmadsga rgsaaqirql agmrglmakp dgsiietpit anfreglnvl qyfisthgar

[0608] 781 kgladtalkt ansgyltrrl vdvaqdlvvt eddcgthegi lmtpvieggd vkeplrdrvl

[0609] 841 grvtaedvlk pgtadilvpr ntllheqwcd lleansvdav kvrsvvscdt dfgvcahcyg

[0610] 901 rdlarghiin kgeaigviaa qsigepgtql tmrtfhigga asraaaessi qvknkgsikl

[0611] 961 snvksvvnss gklvitsrnt elklidefgr tkesykvpyg avmakgdgeq vaggetvanw

[0612] 1021 dphtmpvite vsgfirftdm idgqtitrqt deltglsslv vldsaerttg gkdlrpalki

[0613] 1081 vdaqgndvli pgtdmpaqyf lpgkaivqle dgvqissgdt laripqesgg tkditgglpr

[0614] 1141 vadlfearrp kepailaeia givsfgketk gkrrlvitpv dgsdpyeemi pkwrqlnvfe

[0615] 1201 gervergdvi sdgpeaphdi lrlrgvhavt ryivnevqdv yrlqgvkind khievivrqm

[0616] 1261 lrkatiesag ssdflegeqv eysrvkianr eleangkvga tfsrdllgit kaslatesfi

[0617] 1321 saasfqettr vlteaavagk rdelrglken vivgrlipag tgyayhqdrm rrraageqpa

[0618] 1381 tpqvtaedas aslaellnag lggsdne (서열 번호 91)

[0619] holA (등록 번호 CBW16734.1):

[0620] 1 mirlypeqlr aqlneglraa ylllgndpll lqesqdairl aaasqgfeeh haftldpstd

[0621] 61 wgslfslcqa mslfasrqtl vlqlpengpn aamneqlatl sellhddlll ivrgnkltka

[0622] 121 qenaawytal adrsvqvscq tpeqaqlprw vaarakaqnl qlddaanqll cycyegnlla

[0623] 181 laqalerlsl lwpdgkltlp rveqavndaa hftpfhwvda llmgkskral hilqqlrleg

[0624] 241 sEBVillrtl qrellllvnl krqsahtplr alfdkhrvwq nrrpmigdal qrlhpaqlrq

[0625] 301 avqlltrtei tlkqdygqsv wadleglsll lchkaladvf idg (서열 번호 92)

[0626] dnaC (Registration number CBW20563.1):

[0627] 1 mknvgdlmqr lqkmmpahit pafktgeell awqkeqgeir aaalarenra mkmqrtfnrs

[0628] 61 girplhqncs fdnyrvecdg qmnalskarq yvdefdgnia sfvfsgkpgt gknhlaaaic

[0629] 121 nellrgksv liitvadims amkdtfsnre tseeqllndl snvdllvide igvqtesrye

[0630] 181 kviinqivdr rssskrptgm ltnsnmeemt kmlgervmdr mrlgnslwvn ftwdsyrsrv

[0631] 241 tgkey (sequence number 93)

[0632] eng (EngA Registration number CBW18582.1):

[0633] 1 mvpvvalvgr pnvgkstlfn rltrtrdalv adfpgltrdr kygraevegr eficidtggi

[0634] 61 dgtedgvetr maeqsllaie eadvvlfmvd araglmpade aiakhlrsre kptflvankt

[0635] 121 dgldpdqavv dfyslglgei ypiaashgrg vlsllehvll pwmddvapqe evdedaeywa

[0636] 181 qfeaeqngee apeddfdpqs lpiklaivgr pnvgkstltn rilgeervvv ydmpgttrds

[0637] 241 iyipmerder eyvlidtagv rkrgkitdav ekfsviktlq aiedanvvll vidaregisd

[0638] 301 qdlsllgfil nsgrslvivv nkwdglsqev keqvketldf rlgfidfarv hfisalhgsg

[0639] 361 vgnlfesvre aydsstrrvs tamltrimtm avedhqpplv rgrrvklkya haggynppiv

[0640] 421 vihgnqvkdl pdsykrylmn yfrkslevmg tpiriqfkeg enpyankrnt ltptqmrkrk

[0641] 481 rlmkhikksk (sequence number 94)

[0642] EngB (Registration Number CBW20039.1):

[0643] 1 mmsapdirhl psdcgievaf agrsnagkss alntltnqks lartsktpgr tqlinlfevv

[0644] 61 dgkrlvdlpg ygyaevpeem krkwqralge ylekrqslqg lvvlmdirhp lkdldqqmiq

[0645] 121 wavesniqvl vlltkadkla sgarkaqlnm vreavlafng dvqveafssl kkqgvdklrq

[0646] 181 kldswfsela pveeiqdge (sequence number 95)

[0647] Other inductive promoters for use in the present invention include, but are not limited to, inductively controlling flagella:

[0648] pbad hierarchy

[0649] The entire PBAD sequence having an araC inhibitor (derived from the Invitrogen pbad-his-myc A plasmid).

[0650]

[0651] PBAD promoter sequence

[0652] Aagaaaccaattgtccatattgcatcagacattgccgtcactgcgtcttttactggctcttctcgctaaccaaaccggtaaccccgcttattaaaagcattctgtaacaaagcgggaccaaagccatgacaaaaacgcgtaacaaaagtgtctataatcacggcagaaaagtccacattgattatttgcacggcgtcacactttgctatgccatagcatttttatccataagattagcggatcctacctgacgctttttatcgcaactctctactgtttctccatacccgttttttgggctaacaggaggaattaacc (서열 번호 97)

[0653] AraC inhibitor protein

[0654] Atggctgaagcgcaaaatgatcccctgctgccgggatactcgtttaatgcccatctggtggcgggtttaacgccgattgaggccaacggttatctcgatttttttatcgaccgaccgctgggaatgaaaggttatattctcaatctcaccattcgcggtcagggggtggtgaaaaatcagggacgagaatttgtttgccgaccgggtgatattttgctgttcccgccaggagagattcatcactacggtcgtcatccggaggctcgcgaatggtatcaccagtgggtttactttcgtccgcgcgcctactggcatgaatggcttaactggccgtcaatatttgccaatacggggttctttcgcccggatgaagcgcaccagccgcatttcagcgacctgtttgggcaaatcattaacgccgggcaaggggaagggcgctattcggagctgctggcgataaatctgcttgagcaattgttactgcggcgcatggaagcgattaacgagtcgctccatccaccgatggataatcgggtacgcgaggcttgtcagtacatcagcgatcacctggcagacagcaattttgatatcgccagcgtcgcacagcatgtttgcttgtcgccgtcgcgtctgtcacatcttttccgccagcagttagggattagcgtcttaagctggcgcgaggaccaacgtatcagccaggcgaagctgcttttgagcaccacccggatgcctatcgccaccgtcggtcgcaatgttggttttgacgatcaactctatttctcgcgggtatttaaaaaatgcaccggggccagcccgagcgagttccgtgccggttgtgaagaaaaagtgaatgatgtagccgtcaagttgtcataa (서열 번호 98)

[0655] AraC protein sequence

[0656] MAEAQNDPLLPGYSFNAHLVAGLTPIEANGYLDFFIDRPLGMKGYILNLTIRGQGVVKNQGREFVCRPGDILLFPPGEIHHYGRHPEAREWYHQWVYFRPRAYWHEWLNWPSIFANTGFFRPDEAHQPHFSDLFGQIINAGQGEGR YSELLAINLLEQLLLRRMEAINESLHPPMDNRVREACQYISDHLADSNFDIASVAQHVCLSPSRLSHLFRQQLGISVLSWREDQRISQAKLLLSTTRMPIATVGRNVGFDDQLYFSRVFKKCTGASPSEFRAGCEEKVNDVAVKLS (SEQ ID NO: 99)

[0657] III. Therapeutic DNA, RNA, and Peptides

[0658] The present invention delivers therapeutic DNA, RNA and / or peptides to cancer cells.

[0659] Gene silencing via RNAi (RNA-interference) using short interfering RNA (siRNA) can be used for therapeutic gene silencing. Short hairpin RNA (shRNA) transcribed from small DNA plasmids within target cells has also been shown to mediate stable gene silencing and achieve gene knockdown at levels similar to those obtained by transfection with chemically synthesized siRNA.

[0660] RNAi agents are agents that regulate RNA expression by an RNA interference mechanism. The RNAi agent used in one embodiment of the present invention is a small ribonucleic acid molecule, i.e., an oligoribonucleotide, which is a single ribooligonucleotide (also referred to herein as interfering ribonucleic acid) that assumes a small hairpin formation to create a double structure (g), for example, two distinct oligoribonucleotides hybridized to each other.

[0661] dsRNA can be prepared according to any one of the many methods available in the industry by synthetic chemical approaches, including in vitro and in vivo methods. Single-stranded RNA can also be produced using a combination of enzymatic and organic synthesis or by total organic synthesis. The use of synthetic chemical methods makes it possible to introduce desired modified nucleotides or nucleotide analogs into dsRNA.

[0662] In certain embodiments, instead of the RNAi agent being an interfering ribonucleic acid, e.g., siRNA or shRNA as described above, the RNAi agent may encode an interfering ribonucleic acid, e.g., shRNA as described above. That is, the RNAi agent may be a transcription template of an interfering ribonucleic acid. In these embodiments, the transcription template is generally DNA encoding the interfering ribonucleic acid. The DNA may be present within a vector, wherein various different vectors, e.g., plasmid vectors, viral vectors, etc., are known in the art.

[0663] Alternatively, the activator may be a ribozyme. As used herein for the specification and claims, the term "ribozyme" is interchangeable with "catalytic RNA" and refers to an RNA molecule capable of catalyzing a chemical reaction.

[0664] Exemplary target genes include, but are not limited to, EZH2 (registration number for human EZH2 mRNA: NM_004456), NIPP1 (registration number for human NIPP1 mRNA: NM_002713), and PP1 (registration numbers for human PP1 mRNA: PP1α mRNA: NM_002708; PP1β mRNA: NM_206876; PP1γ mRNA: NM_002710). EZH2, NIPP1, and PP1 will disrupt cancer cell processes and eliminate and / or reduce cancer stem cells. This will prevent the spread / growth of tumors and prevent the formation of metastases.

[0665] In another embodiment, the epigenetic targets are NIPP1 (Registration No. NM_002713), EZH2 (Registration No. NM_004456); PP1α (Registration No. NM_002708); PP1β (Registration No. NM_206876); PP1γ (Registration No. NM_002710); Suz12 (Registration No. NM_015355); EED (Registration No. NM_003797); EZH1 (Registration No. NM_001991); RbAp48 (Registration No. NM_005610); Jarid2 (Registration No. NM_004973); YY1 (Registration No. NM_003403); CBX2 (Registration No. NM_005189); CBX4 (Registration No. NM_003655); CBX6 (Registration No. NM_014292); CBX7 (Registration No. NM_175709); PHC1 (Registration No. NM_004426); PHC2 (Registration No. NM_198040); PHC3 (Registration No. NM_024947); BMI1 (Registration No. NM_005180); PCGF2 (Registration No. NM_007144); ZNF134 (Registration No. NM_003435); RING1 (Registration No. NM_002931); RNF2 (Registration No. NM_0072120; PHF1 (Registration No. NM_024165); MTF2 (Registration No. NM_007358); PHF19 (Registration No. NM_001286840); SETD1A (Registration No. XM_005255723); SETD1B (Registration No. NM_015048); CXXC1 (Registration No. NM_001101654); ASH2L (Registration No. NM_004674); DPY30 (Registration No. NM_032574); RBBP5 (Registration No. NM_005057); WDR5 (Registration No. NM_017588); KMT2A (Registration No. NM_001197104); KMT2D (Registration No. XM_006719616); KMT2B (Registration No NM_014727); KMT2C (Registration No. NM_170606); KAT8 (Registration No. NM_032188); KDM6A (Registration No. NM_001291415); NCOA6 (Registration No. NM_014071);It comprises at least one of PAGR1 (registration number NM_024516); PAXIP1 (registration number NM_007349); ASH1L (registration number NM_018489); SMARCA2 (registration number NM_003070); SMARCA4 (registration number NM_001128844); BPTF (registration number NM_182641); or SMARCA1 (registration number NM_001282874) (e.g., mRNA).

[0666] NIPP1 (Registration No. NM_002713):

[0667] 1 aaatgggagg gggagacgca agatggcggc agccgcgaac tccggctcta gcctcccgct

[0668] 61 gttcgactgc ccaacctggt gagtggcggg gcggccaggg ctagagtggc ccggccggag

[0669] 121 ctagcctggg ctggaaagggc ggctcttttt ttacttttct gctgcgagcc gaacggctca

[0670] 181 gaaaccccgg aatggttgag gaaaaaactgt ttgctgcacc gggccgggcg acgtgttgaa

[0671] 241 gaaccgagag cctggagccc aggcccagga actgaagaaa cccggggttg ggggctcaaa

[0672] 301 ggcgctcact taggcagccc ctttgagcga ttagccagtc gccggagcgc ttcgaggcct

[0673] 361 tggcccgaac ttacgcccaa ctcttgactg agtgcctggt gctctcgtgg agcatcgcat

[0674] 421 ctggcccctt cctgtacgtc ccgagcgcgc tcgagccagc cccggcccca accctacctc

[0675] 481 caagccccgc atccctctgt gttgctgca tcctcgtgc ggcactgtc tgtctgccac

[0676] 541 agagatacg aggggcaggt aagccccctc ccggtttaca tctgtgta gtcaaggag

[0677] 601 aaactaat tgagaactg attattgatg agagaagta tacttattt gggagaacc

[0678] 661 ctgatttgtg tgactttacc attgaccacc agtcttgctc tcggtccat gctgcacttg

[0679] 721 tctaccacaa gcatctgaag agagttttcc tgatagatct cacagtaaa cctgacagag

[0680] 781 ttcacactg cccacacaa gcggattctct acccttacca ttgaggagggg aaatctggac

[0681] 841 attcaagac siagaggaa gaggagaac tcacgggtga cattcagtga ggatgatgag

[0682] 901 atcatcacc cagaggatgt ggatccctca gttggtcgat tcaggacat gtgcaact

[0683] 961 gcagtggtcc cagtcaagaa gaagcgtgtg gaggccctg gctccctggg cctggaggaa

[0684] 1021 tcagggagca ggcgcatgca gaactttgcc ttcagcggag gactctacgg gggcctgccc

[0685] 1081 cccacacaca gtgaagcagg ctcccagcca catggcatcc atgggacagc actcatcggt

[0686] 1141 ggcttgccca tgccataccc aaaccttgcc cctgatgtgg acttgactcc tgttgtgccg

[0687] 1201 tcagcagtga acatgaaccc tgcaccaaac cctgcagtct ataaccctga agctgtaaat

[0688] 1261 gaacccaaga agaagaaata tgcaaaagag gcttggccag gcaagaagcc cacaccttcc

[0689] 1321 ttgctgattt gatatttttg gtcatggaga agggtgggat tgggtgggaa tggggtggaa

[0690] 1381 gggtgatggg gagctaatga actagggaga aaaactttcc atgtgtgcgg tatcgtcttt

[0691] 1441 cagaatgtct cctggcatcc taaccatgta atatgacaat tgggggtggg gttgaaatag

[0692] 1501 cccataaaga cctgtcttca caacacttgc attgtagaga aaggcttctt atatcctttt

[0693] 1561 caatagactg ccctggctct ttcctaggcc ttccactacc tcctttcttt ctcccacttt

[0694] 1621 ctaggatcat tttatgtaa agtcacatat cccaggccct caggttgaat ccagagctgt

[0695] 1681 agaggttaca gtagcatcac cagccttggg ggtccagagc ctaatttata ttcactatcc

[0696] 1741 ttccaagtcc cgggtagcag aagggttgcc atagatctca gttgatcaa aaagaaggct

[0697] 1801 tagaattctg cagttaagct gaggtttaaa ctaaaaaatg tttccttggg tcagtggtttt

[0698] 1861 tgaggtccag tagctaggct tttctcttt gtccttcctg ttggaatgaa aacatttcga

[0699] 1921 ttttccttca tctgtgactg gtgccataga cacaggttta tagttttaac ttacagtatt

[0700] 1981 gtttgaaatt tacctgtttt tcttgtcaaa cctgagcact cctcctgctg aagtttctta

[0701] 2041 tttaattcca gagtactgtc ctctactcta aggcattact tttaagtgta ttgaaggc

[0702] 2101 agttttcaaa ggatatgacc agttggggta attcaaatta aaaaggaaaa gatttgtttg

[0703] 2161 gaagtaactg gtgtctctaa gaggaattttt tagatgtcag tttggaggct cttcccccc

[0704] 2221 tcaattgaga gctcttgtta ttcagagctc caagactaga cctggctaac aaacatagga

[0705] 2281 gacaaagtta ggaaacattg atacaagctt tgtacagaga tttgtacatt tgtgtaatag

[0706] 2341 gccttttcat gctttatgtg tagcttttta cctgtaacct ttattacatt gtaaattaaa

[0707] 2401 cgtaactttt gtcatttggg tgcaggctgt gaatttgtct ctcagtcact gattgccact

[0708] 2461 gccatctgga aatgtttgct aaaggcacag tcactgggct tgggaggcaa tgctccatcc

[0709] 2521 ccattatatt acaaataaag atgccctaaa tgagtgtg (서열 번호 100)

[0710] EZH2 (등록 번호 NM_004456)

[0711] 1 ggcggcgctt gattgggctg ggggggccaa ataaaagcga tggcgattgg gctgccgcgt

[0712] 61 ttggcgctcg gtccggtcgc gtccgacacc cggtgggact cagaaggcag tggagccccg

[0713] 121 gcggcggcgg cggcggcgcg cgggggcgac gcgcgggaac aacgcgagtc ggcgcgcggg

[0714] 181 acgaagaata atcatgggcc agactgggaa gaaatctgag aagggaccag tttgttggcg

[0715] 241 gaagcgtgta aaatcagagt acatgcgact gagacagctc aagaggttca gacgagctga

[0716] 301 tgagtaag agtatgttta gttccaatcg tcagaaatt ttggaagaa cggaatctt

[0717] 361 aaaccaagaa tggaacagc gaaggataca gcctgtgcac atcctgactt ctgtgagctc

[0718] 421 attgcgcggg actagggagt gttcggtgac cagtgacttg gatttttccaa cacaagtcat

[0719] 481 cccattaaag actctgaatg cagttgctc agtacccata atgtattctt gtctcccct

[0720] 541 acagcagaat ttatggtgg aagatgaac tgttcat aacattcctt atatgggaga

[0721] 601 tgaagtttta gatcaggatg gtactttcat tgagaacta aaaaaattt atgatgggaa

[0722] 661 agtacacgggg gatagagaat gtggtttat aaatgatgaa atttttgtgg agttggtgaa

[0723] 721 tgcccttggt caataatg atgatgacga tgatgatgat ggagacgatc ctgaagaag

[0724] 781 agaagaaag cagaagatc tggagatca ccgagatgat aaagaaagcc gcccacccg

[0725] 841 gaaatttcct tctgataaaa ttttgaagc cattcctca atgttccag ataagggcac

[0726] 901 agcagagaa ctaaggaaaataataaa actcaccgaa cagcagctcc caggcgcact

[0727] 961 tcctcctgaa tgtaccccca acatagatgg accaatgct aaatctgttc agagagagca

[0728] 1021 aagcttacac tcctttcata cgctttctg taggcgt ttataatg actgcttcct

[0729] 1081 acatcgtaag tgcaattatt ctttcatgc aacaccaac acttataagc ggagacac

[0730] 1141 agaacagct ctagacaaca aaccttgtgg accacagtgt taccagcatt tggaggcc

[0731] 1201 aaaggagttt gctgctgctc tcaccgctga gcggataag accccacca aacgtccagg

[0732] 1261 aggccgaga agaggacggc ttcccataa cagtagcagg cccagcacccc ccaccattaa

[0733] 1321 tgtgctggaa tcaaggata cagacagtga tagggagca gggactgaa cgggggaa

[0734] 1381 gaagaagaaagaagaaagaaact tcgagctcct ctgaagcaaa

[0735] 1441 ttctcggtgt caaacaccaa taaagatgaa gccaaatatt gaacctcctg agaatgtgga

[0736] 1501 gtggagtggt gctgaagcct caatgtttag agtcctcatt ggcacttact atgacaattt

[0737] 1561 ctgtgccatt gctaggttaa ttgggaccaa aacatgtaga caggtgtatg agtttagagt

[0738] 1621 caaagaatct agcatcatag ctccagctcc cgctgaggat gtggatactc ctccaaggaa

[0739] 1681 aaagaagagg aaacaccggt tgtgggctgc acactgcaga aagatacagc tgaaaaagga

[0740] 1741 cggctcctct aaccatgttt acaactatca accctgtgat catccacggc agccttgtga

[0741] 1801 cagttcgtgc ccttgtgtga tagcacaaaa tttttgtgaa aagtttgtc aatgtagttc

[0742] 1861 agagtgtcaa aaccgctttc cgggatgccg ctgcaaagca cagtgcaaca ccaagcagtg

[0743] 1921 cccgtgctac ctggctgtcc gagagtgtga ccctgacctc tgtcttactt gtggagccgc

[0744] 1981 tgaccattgg gacagtaaaa atgtgtcctg caagaactgc agtattcagc ggggctccaa

[0745] 2041 aaagcatcta ttgctggcac catctgacgt ggcaggctgg gggattttta tcaaagatcc

[0746] 2101 tgtgcagaaa aatgaattca tctcagaata ctgtggagag attatttctc aagatgaagc

[0747] 2161 tgacagaaga gggaaagtgt atgataaata catgtgcagc tttctgttca acttgaacaa

[0748] 2221 tgatttgtg gtggatgcaa cccgcaaggg taacaaaatt cgttttgcaa atcattcggt

[0749] 2281 aaatccaaac tgctatgcaa aagttatgat ggttaacggt gatcacagga taggtatttt

[0750] 2341 tgccaagaga gccatccaga ctggcgaaga gctgtttttt gattacagat acagccaggc

[0751] 2401 tgatgccctg aagtatgtcg gcatcgaaag agaaatggaa atcccttgac atctgctacc

[0752] 2461 tcctcccccc tcctctgaaa cagctgcctt agcttcagga acctcgagta ctgtgggcaa

[0753] 2521 tttagaaaaa gaacatgcag tttgaaattc tgaatttgca aagtactgta agaataattt

[0754] 2581 atagtaatga gtttaaaaat caacttttta ttgccttctc accagctgca aagtgttttg

[0755] 2641 taccagtgaa tttttgcaat aatgcagtat ggtacatttt tcaactttga ataaagaata

[0756] 2701 cttgaacttg tccttgttga etc.

[0757] PP1α (registered number NM_002708)

[0758] 1 gcggggccgc gggccgggg cggactgggg cgggcggaag gagagccagg ccggaaggag

[0759] 61 gctgccggag ggcgggaggc aggagcgggc caggagctgc tgggctggag cggcggcgcc

[0760] 121 gccatgtccg acagcgagaa gctcaacctg gactcgatca tcgggcgcct gctggaagtg

[0761] 181 cagggctcgc ggcctggcaa gaatgtacag ctgacagaga acgagatccg cggtctgtgc

[0762] 241 ctgaaatccc gggagatttt tctgagccag cccattcttc tggagctgga ggcacccctc

[0763] 301 aagatctgcg gtgacataca cggccagtac tacgaccttc tgcgactatt tgagtatggc

[0764] 361 ggtttccctc ccgagagcaa ctacctcttt ctggggact atgtggacag gggcaagcag

[0765] 421 tccttggaga ccatctgcct gctgctggcc tataagatca agtaccccga gaacttcttc

[0766] 481 ctgctccgtg ggaccacga gtgtgccagc atcaaccgca tctatggttt ctacgatgag

[0767] 541 tgcaagagac gctacaacat caaactgtgg aaaaccttca ctgactgctt caactgcctg

[0768] 601 cccatcgcgg ccatagtgga cgaaagatc ttctgctgcc acggaggcct gtccccggac

[0769] 661 ctgcagtcta tggagcagat tcggcggatc atgcggccca cagatgtgcc tgaccagggc

[0770] 721 ctgctgtgtg acctgctgtg gtctgaccct gacaaggacg tgcagggctg gggcgagaac

[0771] 781 gaccgtggcg tctcttttac ctttggagcc gaggtggtgg ccaagttcct ccacaagcac

[0772] 841 gacttggacc tcatctgccg agcacaccag gtggtagaag acggctacga gttctttgcc

[0773] 901 aagcggcagc tggtgacact tttctcagct cccaactact gtggcgagtt tgacaatgct

[0774] 961 ggcgccatga tgagtgtgga cgagaccctc atgtgctctt tccagatcct caagcccgcc

[0775] 1021 gacaagaca aggggagta cgggcagttc agtggcctga accctggagg ccgacccatc

[0776] 1081 accccacccc gcaattccgc caaagccaag aaatagcccc cgcacaccac cctgtgcccc

[0777] 1141 agatgatgga ttgattgtac agaaatcatg ctgccatgct gggggggggt caccccgacc

[0778] 1201 cctcaggccc acctgtcacg gggaacatgg agccttggtg tatttttctt ttcttttttt

[0779] 1261 aatgaatcaa tagcagcgtc cagtccccca gggctgcttc ctgcctgcac ctgcggtgac

[0780] 1321 tgtgagcagg atcctggggc cgaggctgca gctcagggca acggcaggcc aggtcgtggg

[0781] 1381 tctccagccg tgcttggcct cagggctggc agccggatcc tggggcaacc catctggtct

[0782] 1441 cttgaataaa ggtcaaagct ggattctcgc aaaaaaaaaa aaaaaaaa (서열 번호 102)

[0783] PP1β (등록 번호 NM_206876)

[0784] 1 gctgcgtgac gcggcggcgc gcaagggacg tgcggagtga gtggcgctgc gggtggggcc

[0785] 61 gtcggcggcg ctggtgagag aacgccgagc cgtcgccgca gcctccgccg ccgagaagcc

[0786] 121 cttgttcccg ctgctgggaa ggagagtctg tgccgacaag atggcggacg gggagctgaa

[0787] 181 cgtggacagc ctcatcaccc ggctgctgga ggtacgagga tgtcgtccag gaagattgt

[0788] 241 gcagatgact gagcagaag tcgaggctt atgtatcag tctcgggaga tcttctcag

[0789] 301 ccagcctatt cttggaat tggaagcacc gctgaaatt tgtggagata ttcatggaca

[0790] 361 atacagat ttactgagat tatttgaata tggaggttc ccaccagaag ccaactatct

[0791] 421 tttcttagga gattatgtgg acagaggaaa gcagtcttg gaaaccattt gtttgctatt

[0792] 481 ggcttataaa atcaatatc cagagaactt ctttctct agaggaacc atgagtgtgc

[0793] 541 tagcatcaat cgcatttatg gattctatga tgaatgcaa cgagattta atattaaatt

[0794] 601 gtggaagacc ttcactgat gtttactg tctgcctata gcagccattg tggatgaga

[0795] 661 gatcttctgt tgtcatggag gattgtcacc agacctgca tctatggagc agattcggag

[0796] 721 aattatgaga cctactgatg tccctgatac aggtttgctc tgtgatttgc tatggtctga

[0797] 781 tccagataag gatgtgcaag gctggggaga aaatgatcgt ggtgtttcct ttacttttgg

[0798] 841 agctgatgta gtcagtaaat ttctgaatcg tcatgattta gatttgattt gtcgagctca

[0799] 901 tcaggtggtg gaagatggat atgaattttt tgctaaacga cagttggtaa ccttattttc

[0800] 961 agccccaaat tactgtggcg agtttgataa tgctggtgga atgatgagtg tggatgaaac

[0801] 1021 tttgatgtgt tcatttcaga tattgaaacc atctgaaaag aaagctaaat accagtatgg

[0802] 1081 tggactgaat tctggacgtc ctgtcactcc acctcgaaca gctaatccgc cgaagaaag

[0803] 1141 gtgaagaaag gaattctgta aagaaaccat cagatttgtt aaggacatac ttcataatat

[0804] 1201 ataagtgtgc actgtaaaac catccagcca tttgacaccc tttatgatgt cacaccttta

[0805] 1261 acttaaggag acgggtaaag gatcttaaat ttttttctaa tagaaagatg tgctacactg

[0806] 1321 tattgtaata agtatactct gttatagtca acaaagttaa atccaaattc aaaattatcc

[0807] 1381 attaaagtta catcttcatg tatcacaatt tttaaagttg aaaagcatcc cagttaaact

[0808] 1441 agatgtgata gttaaaccag atgaaagcat gatgatccat ctgtgtaatg tggttttagt

[0809] 1501 gttgcttggt tgtttaatta ttttgagctt gttttgtttt tgtttgtttt cactagaata

[0810] 1561 atggcaaata cttctaattt ttttccctaa acatttttaa aagtgaaata tgggaagagc

[0811] 1621 tttacagaca ttcaccaact attattttcc cttgtttatc tacttagata tctgtttaat

[0812] 1681 cttactaaga aaactttcgc ctcattacat taaaaaggaa tttatagagat tgattgtttt

[0813] 1741 aaaaaaaaat acgcacattg tccaatccag tgattttaat catacagttt gactgggcaa

[0814] 1801 actttacagc tgatagtgaa tattttgctt tatacaggaa ttgacactga tttggatttg

[0815] 1861 tgcactctaa tttttaactt attgatgctc tattgtgcag tagcatttca tttaagataa

[0816] 1921 ggctcatata gtattaccca actagttggt aatgtgatta tgtggtacct tggctttagg

[0817] 1981 ttttcattcg cacggacac cttttggcat gcttaacttc ctggtaacac cttcacctgc

[0818] 2041 attggttttc ttttcttttt ttctttcttt ttttttttttttttttttttttttttttttgt

[0819] 2101 ttgtttttag atccacagta catgagaatc cttttttgac aagccttgga aagctgacac

[0820] 2161 tgtctctttt tcctccctct atacgaagga tgtatttaaa tgaatgctgg tcagtgggac

[0821] 2221 attttgtcaa ctatgggtat tgggtgctta actgtctaat attgccatgt gaatgttgta

[0822] 2281 tacgattgta aggcttatgt cactaaagat ttttattctg attttttcat aatcaaaggt

[0823] 2341 catatgatac tgtatagaca agctttgtag tgaagtatag tagcaataat ttctgtacct

[0824] 2401 gatcaagttt attgcagcct ttctttttcct atttcttttt tttaagggtt agtattaaca

[0825] 2461 aatggcaatg agtagaaaag ttaacatgaa gattttagaa ggagagaact tacaggacac

[0826] 2521 agatttgtga ttctttgact gtgacactat tggatgtgat tctaaaagct tttattgagc

[0827] 2581 attgtcaaat ttgtaagctt catagggatg gacatcatat ctataatgcc cttctatatg

[0828] 2641 tgctaccata gatgtgacat ttttgacctt aatatcgtct ttgaaaatgt taaattgaga

[0829] 2701 aacctgttaa cttacatttt atgaattggc acattgtatt acttactgca agagatattt

[0830] 2761 cattttcagc acagtgcaaa agttctttaa aatgcatatg tctttttttc taattccgtt

[0831] 2821 ttgttttaaa gcacatttta aatgtagttt tctcatttag taaaaagttgt ctaattgata

[0832] 2881 tgaagcctga ctgatttttt ttttccttac agtgagacat ttaagcacac attttattca

[0833] 2941 catagatact atgtccttga catattgaaa tgattctttt ctgaaagtat tcatgatctg

[0834] 3001 catatgatgt attaggttag gtcacaaagg ttttatctga ggtgatttaa ataacttcct

[0835] 3061 gattggagtg tgtaagctga gcgatttcta ataaaatttt agttgtacac ttttagtagt

[0836] 3121 catagtgaag caggtctaga aaataagcct ttggcaggga aaaagggcaa tgttgattaa

[0837] 3181 tctcagtatt aaaccacatt aatctgtatc ccattgtctg gctttgtaa attcatccag

[0838] 3241 gtcaagacta agtatgttgg ttaataggaa tcctttttt ttttttaaa gactaatgt

[0839] 3301 Gaaaaaaaat tcactaaa tattgtcat taaatttaaa ggatggaaat

[0840] 3361 ttcatgtt taaaaattat tcaagcactc ttaaaaccc ttaacagcc tccagtcata

[0841] 3421 aaatgtgtt ctttacaaat atttgcttgg cacacgact tgaaataat aaaactttgt

[0842] 3481 ttcttaggag aaaatgattc tgtaatcca gtgtcactaa tttatattt tctttctct

[0843] 3541 gattttttc aggttagtga ttttttgta tacaatttaa tccaatgtt atgacattca

[0844] 3601 gaatcatga aacacagtag atatctgtta taatgtggtg tatcacatgg attataagc

[0845] 3661 aaagttatgg tcgattcta ttctgaaag atcaacac agtgaatcct ttgcatttga

[0846] 3721 agccttaaca tgcattgctt taatttgcc cagggacaa tttataat cagcagact

[0847] 3781 gtttgtgca aagcgttgag tcatcaggta tttagagcct agccagctac ccagtatcca

[0848] 3841 tgctgccata tccctcatt gtaaaagta cctaacatt cgtgaatga ttttttag

[0849] 3901 ctgaaaatg ctggcaagaa gattttaa gcttaaaa ggtggtaaat ttgaagtag

[0850] 3961 agtgtgttca cgagaaacat aggctttca aaaaaatttt tattcaggc aaagcaagga

[0851] 4021 acatcttgag atatgtctca agaatataaa gatgtattat tttaagccaa ggagctgaaa

[0852] 4081 tatatctcag tttataaatt cagtatatt ctttttgtct ccatggcaac cataactttt

[0853] 4141 gaaccaaaa aaattgtttt tacatcttta tgctgaaat gtgtttagat taggaatatg

[0854] 4201 gtcggggctga atttgctgtt gctccctaac caatccacc tctgttttc cttgtgagtc

[0855] 4261 catggctaa tcaagctgc ccctgagaag agacttaatc caagcctgat tgtactagtg

[0856] 4321 gcatcactta gaagtaggct ttcccttc ctagtagatc tcaatgtttt atattcctt

[0857] 4381 aaaacagctg aaaattggga caacatactt tacgcaatga acagtagtta aataggaaat

[0858] 4441 aaactagttc catataagta tacacctaga gttttaatta cctttataat gtttcttaaa

[0859] 4501 agtgaaactt agatacaatt gtgattggat acttagatac taagtgaaac ttagtgtaac

[0860] 4561 aattttgatc tgttaaattg gattttacat gtacatttga atgccagaat ttctaaataa

[0861] 4621 atcccctggt taggaaattt taaaagtcaa agcttgtttt cttcaaccac taccttctac

[0862] 4681 attggttgac ttagaccgta agctttttaa gtttctcatt gtaatttacc ttctcatgca

[0863] 4741 gattgctgat gttttattaa accttatttt tacaaaaatg aaaaaa (서열 번호 103)

[0864] PP1γ (등록 번호 NM_002710)

[0865] 1 taaagaagtc ccggccgggc cgctgcactc cccgcgcgca tccgtgcgcc gccgaggct

[0866] 61 gtctaaggag tcggcggcca tttgttctt ctcgtggttc cagtggggag agaaggagga

[0867] 121 agtagggagc ggggtggcag gggggggacc cgccgcggct gctgccaccg ccgccaccac

[0868] 181 cgcctctgct cgtggcgtgg gaaaggaggt gtgagtcccg ggcgcgagcc ggcggcggcg

[0869] 241 ccgctgcggg agggtcggcg gtgggaaggc gatggcggat ttagataaac tcaacatcga

[0870] 301 cagcattatc caacggctgc tggaagtgag agggtccaag cctggtaaga atgtccagct

[0871] 361 tcaggagaat gaaatcagag gactgtgctt aaagtctcgt gaaatctttc tcagtcagcc

[0872] 421 tatcctacta gaacttgaag caccactcaa aatatgtggt gacatccatg gacaatacta

[0873] 481 tgatttgctg cgactttttg agtacggtgg tttcccacca gaaagcaact acctgtttct

[0874] 541 tggggactat gtggacaggg gaaagcagtc attggagacg atctgcctct tactggccta

[0875] 601 caaaataaaa tatcctgaga atttttttct tctcagaggg aaccatgaat gtgccagcat

[0876] 661 caacagaatt tatggatttt atgatgaatg taaaagaaga tacaacatta aactatggaa

[0877] 721 aactttcaca gactgtttta actgtttacc gatagcagcc atcgtggatg agaagatatt

[0878] 781 ctgctgtcat ggaggtttat caccagatct tcaatctatg gagcagattc ggcgaattat

[0879] 841 gcgaccaact gatgtaccag atcaaggtct tctttgtgat cttttgtggt ctgaccccga

[0880] 901 taaagatgtc ttaggctggg gtgaaaatga cagaggagtg tccttcacat ttggtgcaga

[0881] 961 agtggttgca aaatttctcc ataagcatga tttggatctt atatgtagag cccatcaggt

[0882] 1021 ggttgaagat ggatatgaat tttttgcaaa gaggcagttg gtcactctgt tttctgcgcc

[0883] 1081 caattattgc ggagagtttg acaatgcagg tgccatgatg agtgtggatg aaacactaat

[0884] 1141 gtgttctttt cagattttaa agcctgcaga gaaaaagaag ccaaatgcca cgagacctgt

[0885] 1201 aacgcctcca aggggtatga tcacaaagca agcaaagaaa tagatgtcgt tttgacactg

[0886] 1261 cctagtcggg acttgtaaca tagagtatat aaccttcatt tttaagactg taatgtgtac

[0887] 1321 tggtcagctt gctcagatag atctgtgttt gtgggggccc ttccttccat ttttgattta

[0888] 1381 gtgaatggca tttgctggtt ataacagcaa atgaaagact cttcactcca aaaagaaaag

[0889] 1441 tgttttgttt tttaattctc tgttcctttt gcaaacaatt ttaatgatgg tgttaaagct

[0890] 1501 gtacacccca ggacagttta tcctgtctga ggagtaagtg tacaattgat cttttttaat

[0891] 1561 tcagtacaac ccataatcat gtaaatgctc attttcttta ggacataaag agagccctag

[0892] 1621 ggtgctctga atctgtacat gttcttgtca taaaatgcat actgttgata caaaccactg

[0893] 1681 tgaacatttt ttatttgaga attttgtttc aaagggattg ctttttcctc tcattgtctt

[0894] 1741 gttatgtaca aactagtttt tatagctatc aacattagga gtaactttca accttgccag

[0895] 1801 catcactggt atgatgtata tttaattaaa gcacactttt ccccgaccgt atacttaaaa

[0896] 1861 tgacaaagcc attcttttaa atatttgtga ctctttccta aagccaaagt ttctgttgaa

[0897] 1921 ttatgttttg acacacccct aagtacaagg tggtatggtt gtatacacat gctgccttct

[0898] 1981 tggggattca aaaacaggtt tttgattttg aatagcaatt agtgatatag tgctgtttaa

[0899] 2041 gctactaacg ataaaaggta ataacatttt atacaatttc catatagtct attcattaag

[0900] 2101 taatcttttt acagttgcat caggcctgaa cccgtccatt cagaaagctt caaattatag

[0901] 2161 aaacaatact gttctatacg agtgaccgat tatgctttct ttggcctaca ttctttattc

[0902] 2221 tgcggtgaag ttgaggctta taagttaaaa caaaggaact aacttactgt ccaccagttt

[0903] 2281 atacagaact cacagtacct atgactttt taaactaaga tctgttaaaa aagaaatctg

[0904] 2341 tttcaacaga tgaccgtgta caataccgtg tggtgaaaat gaattcagac ttattaaatg

[0905] 2401 atgaacttgt taaatcttct cagtgtctat ttatcagcac aatacacaca ggagaactgt

[0906] 2461 tgatggcata ttgaatagat tttcctgaat aaattgctct ggaaccaca caaaaaaaaa

[0907] 2521 aaaaaa (서열 no 104)

[0908] Suz12 (registration number NM_015355):

[0909] 1 ggtgagcggc ctccgaagcg gagcggggct ctgaggagac actttttttt tcctccctcc

[0910] 61 ttccctctc tcctctccc ttcccttccc ctctctccc ctctctctc cttccccccct

[0911] 121 cggtccgccg gagcctgctg gggcgagcgg ttggtattgc aggcgcttgc tctccggggc

[0912] 181 cgcccggcgg gtagctggcg gggggaggag gcaggaaccg cgatggcgcc tcagaagcac

[0913] 241 ggcggtgggg gagggggcgg ctcggggccc agcgcggggt ccgggggagg cggcttcggg

[0914] 301 ggttcggcgg cggtggcggc ggcgacggct tcgggcggca aatccggcgg cgggagctgt

[0915] 361 ggagggggtg gcagttactc ggcctcctcc tcctcctccg cggcggcagc ggcggggct

[0916] 421 gcggtgttac cggtgaagaa gccgaaaatg gagcacgtcc aggctgacca cgagcttttc

[0917] 481 ctccaggcct ttgagaagcc aacacagatc tatagatttc ttcgaactcg gaatctcata

[0918] 541 gcaccaatat ttttgcacag aactcttact tacatgtctc atcgaaactc cagaacaaac

[0919] 601 atcaaaagga aaacatttaa agttgatgat atgttatcaa aagtagagaa aagaaagga

[0920] 661 gagcaagaat ctcatagctt gtcagctcat ttgcagctta cgtttactgg tttcttccac

[0921] 721 aaaaatgata agccatcacc aaactcaagaa aatgaacaaa attctgttac cctggaagtc

[0922] 781 ctgcttgtga aagtttgcca caaaaaaaaga areatgtaa gttgtccaat aaggcaagtt

[0923] 841 cccacaggta aaaagcaggt gcctttgaat cctgacctca atcaaaaa accccggaaat

[0924] 901 ttcccgtccc ttgcagtttc cagtaatgaa tttgaaccta gtaacagcca tatggtgaag

[0925] 961

[0926] 1021 aatggagaaa ccaatgaaaa tattgatgtc aatgaagagc ttccagccag aagaaaacga

[0927] 1081 aatcgtgagg atgggggaaaa gacatttgtt gcaaaatga foottttga taaaaacagg

[0928] 1141

[0929] 1201 ataagcaaga aaagagcaac atgggagact attcttgatg ggaagaggct gcctccattc

[0930] 1261 gaaacatttt ctcagggacc tacgttgcag ttcactcttc gttggacagg agagaccaat

[0931] 1321 gataaatcta cggctcctat tgccaaacct cttgccacta gaaattcaga gagtctccat

[0932] 1381 caggaaaaca agcctggttc agttaaacct actcaaacta ttgctgttaa agaatcattg

[0933] 1441 actacagatc tacaaacaag aaaagaaaag gatactccaa atgaaaaccg acaaaaatta

[0934] 1501 agaatatttt atcagtttct ctataacaac aatacaaggc aacaaactga agcaagagat

[0935] 1561 gacctgcatt gcccttggtg tactctgaac tgccgcaaac tttatagttt actcaagcat

[0936] 1621 cttaaactct gccatagcag atttatcttc aactatgttt atcatccaaa aggtgctagg

[0937] 1681 atagatgttt ctatcaatga gtgttatgat ggctcctatg caggaaatcc tcaggatatt

[0938] 1741 catcgccaac ctggatttgc ttttagtcgc aacggaccag ttaagagaac acctatcaca

[0939] 1801 catattcttg tgtgcaggcc aaaacgaaca aaagcaagca tgtctgaatt tcttgaatct

[0940] 1861 gaagatgggg aagtagaaca gcaaagaaca tatagtagtg gccacaatcg tctgtatttc

[0941] 1921 catagtgata cctgcttacc tctccgtcca caagaaatgg aagtagtag tgaagatgaa

[0942] 1981 aaggatcctg aatggctaag agaaaaaacc attacacaaa ttgaagagtt ttctgatgtt

[0943] 2041 aatgaaggag agaaagaagt gatgaaactc tggaatctcc atgtcatgaa gcatgggttt

[0944] 2101 attgctgaca atcaaatgaa tcatgcctgt atgctgtttg tagaaatta tggacagaaa

[0945] 2161 father agaatttatg tcgaaacttc atgcttcatc tagtcagcat gcatgacttt

[0946] 2221 aatcttatta gcataatgtc aatagataaa gctgttacca agctccgtga aatgcagcaa

[0947] 2281 aaatagaaa agggggaatc tgcttcccct gcaaacgaag aaataactga agaacaaaat

[0948] 2341 gggacagcaa atggatttag tgaattaac tcaaaagaga aagctttgga aacagatagt

[0949] 2401 gtctcagggg tttcaaaaca gagcaaaaaa caaaaactct gaaaagctct aaccccatgt

[0950] 2461 tatggacaaa cactgaaatt acattttagggaattcatcc tctaaaatt atgtttttgt

[0951] 2521 ttttaatcat atgttccaaa caggcactgt tagatgaagt aaatgatttc aacaaggata

[0952] 2581 tttgtatcag ggttctactt cacttcatta tgcagcatta catgtatatc acttttattg

[0953] 2641 atgtcattaa aacattctgt actttaagca tgaaaagcaa tatttcaaag tatttttaaa

[0954] 2701 ctcaacaaat gtcatcaaat atgttgaatt gatctagaaa ttatttcata tataaatcag

[0955] 2761 aatttttttg catttatgaa cggctgtttt tctactttgt aattgtgaga cattttcttg

[0956] 2821 gggagggaaa attggaatgg ttcccttttt tagaaattga agtggtcttc atatgtcaac

[0957] 2881 tacagaaaag gaaaaaaata gaaattgaag gatttttatg aaattatatt gcattactat

[0958] 2941 ttgcagtcaa actttgatcc ttgtttttga aatcatttgt caattcggaa tgaaaaatta

[0959] 3001 taatgtatt ttacattaca taagttcctt ttacattaa aaatagcac ttctcattac

[0960] 3061 tatgcctgtt tgagagata ttaaattttc acatgttga cagtgaaatg ctatgttggt

[0961] 3121 ttataagatt acagaccatt tgtttcatg tggataattt tagtgcattg ctcaccggt

[0962] 3181 atgtttttt ttttaactt gaacatttg cttgttttgtt ttttcttt taattagata

[0963] 3241 atcacacgga aattaagct gttcatatct ttaattagg attgcaacc aaggaaagaa

[0964] 3301 cgcatttgag atttttagat gtcacttata agggagag tgttctttaa aagtcaacca

[0965] 3361 gaaaactgtt atgcctttta ttgtttgca aggatgtctt tgtaatgtgt ttcatgaata

[0966] 3421 gatatcca taggataag ctgacttgaa tcatttgag caatttgcc ctgtgttata

[0967] 3481 tgtgttcac gcacatattt gcagttggat tttctcac agaagtgga ttcactactg

[0968] 3541 gcacattaac aagcaccaat aggtttat tcacactcg agcactgtgg ttgagtaaca

[0969] 3601 tcacctcaat ttatttat ccttaaagat attgcatttt catattctt atttataaag

[0970] 3661 gatcaatgct gctgtaata cagtatttt taattttaa atttcattcc accaccatca

[0971] 3721 gatgcagttc cctattttgt ttaatgaagg gatatataag ctttctaatg gtgtcttcag

[0972] 3781 aaatttataa aatgtaaata ctgatttgac tggtctttaa gatgtgttta actgtgaggc

[0973] 3841 tattaacga atagtgtgga tgtgatttgt catccagtat taagttctta gtcattgatt

[0974] 3901 ttgtgttta aaaaaaaata ggaaagaggg aaactgcagc ttcattaca gattccttga

[0975] 3961 ttggtaagct ctccaatga tgagttctag taactctga ttttgctc tggatagtag

[0976] 4021 atctcgagcg ttatctcgg gctttaattt gctaaagctg tgcacatatg taaaaaaaaa

[0977] 4081 aaaaaaaga ttattttagg ggagatgtag gtgtagaatt attgcttag tcatttctta

[0978] 4141 agcagttatg ctcttaatgc ttaaaagaag gctagcattg tttgcacaaa aagttggtga

[0979] 4201 ttcccacccc aatagtaat aaaattactt ctgttgagta aactttttat gtcatcgtaa

[0980] 4261 aagctgaaa aatccctttg tttctattta taaaaaaagt gcttttctat atgtaccctt

[0981] 4321 gataacagat tttgaagaaa tcctgtaaga tgataaagca tttgaatggt acagtagatg

[0982] 4381 taaaaaaaat tcagtttaaa agaacatttg ttttacatt aaatgttat ttgaaatcaa

[0983] 4441 atgatttgt acataaagtt caataatata aaagctg (서열 번호 105)

[0984] EED(등록 번호 NM_003797):

[0985] 1 cgctttgaaa tccaccctgg gattcggaaa ccgggtagaa aactacctgg ttcagcaaac

[0986] 61 gagaattcaa acagaggagg ggcttggagg aggcgggttt cgacgaaccc agcgcaagag

[0987] 121 tacgccacgg cgcctgcgca tccctgacg ggtactttcc attcgccaga tgggggaagc

[0988] 181 caggggaag caggttactg ttttgcatt tctatcttca aggaagaatt aggttatgaa

[0989] 241 tagttccgtg aatagtcagg aagcgctgtc ctccaagttc aagattaagg aaacgtggca

[0990] 301 tgcacagcta aagcaagagg tgacgtcttg tatcttcccc cgtttcctgg gacattggtg

[0991] 361 gtgtagccca ttccacagac tttcgctccc tagcagcggg tcggagatcg aaggaacggg

[0992] 421 ccaattgcgg ctgaaacgtc tttggaagga ggaagggggt gagggagcat ccctttgagt

[0993] 481 ttcgcctctt ctcgaggcgg tggtgggaag ggagacatac ttaatactgc cctcttaatc

[0994] 541 caacggacct tacatcgtgt agactgccgg gagggcggcg ggaaaagggc aagacgggag

[0995] 601 ttggggaagg gaaggagcca ggaagccgcg cgggagggcg cgcgcgcgcg cccctttttc

[0996] 661 agcagtgtgg cggggtcgca cgcacgcccg cctcggcggc tgggcgcgat ttgcgacagt

[0997] 721 ggggggggcg gtggaggtgg cggcggcagc ggcaactttg cggcaagctc gggccgggct

[0998] 781 tgcttgacgg cggtgtggcg gaggccccgc cccaggcggc aggaacctgg agggaggcgg

[0999] 841 aggaatatgt ccgagaggga agtgtcgact gcgccggcgg gaacagacat gcctgcggcc

[1000] 901 aagaagcaga agctgagcag tgacgagaac agcaatccag acctctctgg agaggagaat

[1001] 961

[1002] 1021 acgccaaatg cacctggaag gaaaagttgg ggaaagggaa aatggaagtc aagaaatgc

[1003] 1081 aaatattctt tcaaatgtgt aatagtctc aaagaagatc ataaccaacc attgtttgga

[1004] 1141 gttcagttta actggcacag taagaag gatccattag tgtttgcaac tgtaggaagc

[1005] 1201 aacagagtta ccttgtatga atgtcattca caaggaaa tccggttgtt gcaatcttac

[1006] 1261 gtggatgctg atgctgatga aaacttttac acttgtgcat ggacctatga tagcaatacg

[1007] 1321 agccatcctc tgctggctgt agctggatct agaggcataa ttaggataat aaatcctata

[1008] 1381

[1009] 1441 catccaagag atccaaatct tctcctgtca gtaagtaag atcatgcttt acgattatgg

[1010] 1501 aatatccaga cggacactct ggtggcaata tttggaggcg tagaagggca cagagatgaa

[1011] 1561 gttctaagtg ctgattatga tcttttgggt gaaaaaataa tgtcctgtgg tatggatcat

[1012] 1621 tctcttaaac tttggaggat caattcaaag agaatgatga atgcaattaa ggaatcttat

[1013] 1681 gattataatc caaataaaac taacaggcca tttatttctc agaaaatcca ttttcctgat

[1014] 1741 tttctacca gagacataca taggaattat gttgattgtg tgcgatggtt aggcgatttg

[1015] 1801 atactttcta agtcttgtga aaatgccatt gtgtgctgga aacctggcaa gatggaagat

[1016] 1861 gatatagata aaattaacc cagtgaatct aatgtgacta ttcttgggcg atttgattac

[1017] 1921 agccagtgtg acatttggta catgaggttt tctatggatt tctggcaaaa gatgcttgca

[1018] 1981 ttgggcaatc aagttggcaa actttatgtt tgggatttag aagtagaaga tcctcataaa

[1019] 2041 gccaaatgta caacactgac tcatcataaa tgtggtgctg ctattcgaca aaccagtttt

[1020] 2101 agcagggata gcagcattct tatagctgtt tgtgatgatg ccagtatttg gcgctgggat

[1021] 2161 cgacttcgat aaaatacttt tgcctaatca aaattagagt gtgtttgttg tctgtgtaaa

[1022] 2221 atagaattaa tgtatcttgc tagtaagggc acgtagagca tttagagttg Tctttcagca

[1023] 2281 ttcaatcagg ctgagctgaa tgtagtgatg tttacattgt ttacattctt tgtactgtct

[1024] 2341 tcctgctcag actctactgc tttaataaa aatttatttt tgtaaagctg tgtgtttagt

[1025] 2401 tactttcatt gtggtgaaaa aaagttaaa gtaataaaat tatgccttat cttttaaaa

[1026] 2461 aaaaaaaaaa aaaaaa (서열 no 106)

[1027] EZH1 (registration number NM_001991):

[1028] 1 gcgcatgcgt cctagcagcg ggacccgcgg ctcgggatgg aggctggaca cctgttctgc

[1029] 61 tgttgtgtcc tgccattctc ctgaagaaca gaggcacact gtaaaaccca acacttcccc

[1030] 121 ttgcattcta taagattaca gcaagatgga aataccaaat ccccctacct ccaaatgtat

[1031] 181 cacttactgg aaaagaaaag tgaaatctga atacatgcga cttcgacaac ttaaacggct

[1032] 241 tcaggcaaat atgggtgcaa aggctttgta tgtggcaaat tttgcaaagg ttcaagaaaa

[1033] 301 aacccagatc ctcaatgaag aatggaagaa gcttcgtgtc caacctgttc agtcaatgaa

[1034] 361 gcctgtgagt ggacaccctt ttctcaaaaa gtgtaccata gagagcattt tcccgggatt

[1035] 421 tgcaagccaa catatgttaa tgaggtcact gaacacagtt gcattggttc ccatcatgta

[1036] 481 ttcctggtcc cctctccaac agaactttat ggtagaagat gagacggttt tgtgcaatat

[1037] 541 tccctacatg ggagatgaag tgaaagaaga agatgagact tttattgagg agctgatcaa

[1038] 601 taactatgat gggaaagtcc atggtgaaga agagatgatc cctggatccg ttctgattag

[1039] 661 tgatgctgtt tttctggagt tggtcgatgc cctgaatcag tactcagatg aggaggagga

[1040] 721 agggcacaat gacacctcag atggaaagca ggatgacagc aaagaagatc tgccagtaac

[1041] 781 aagaaagaga aagcgacatg ctattgaagg caacaaaaag agttccaaga aacagttccc

[1042] 841 aaatgacatg atcttcagtg caattgcctc aatgttccct gagaatggtg tcccagatga

[1043] 901 catgaaggag aggtatcgag aactaacaga gatgtcagac cccaatgcac ttccccctca

[1044] 961 gtgcacaccc aacatcgatg gccccaatgc caagtctgtg cagcgggagc aatctctgca

[1045] 1021 ctccttccac acactttttt gccggcgctg ctttaaatac gactgcttcc ttcacccttt

[1046] 1081 tcatgccacc cctaatgtat ataaacgcaa gaataaagaa atcaagattg aaccagaacc

[1047] 1141 atgtggcaca gactgcttcc ttttgctgga aggagcaaag gagtatgcca tgctccacaa

[1048] 1201 cccccgctcc aagtgctctg gtcgtcgccg gagaaggcac cacatagtca gtgcttcctg

[1049] 1261 ctccaatgcc tcagcctctg ctgtggctga gactaaagaa ggagacagtg acagggacac

[1050] 1321 aggcaatgac tgggcctcca gttcttcaga ggctaactct cgctgtcaga ctcccacaaa

[1051] 1381 agaaggct agtccagccc cacctcaact ctgcgtagtg gaagcaccct cggagcctgt

[1052] 1441 ggaatggact ggggctgaag aatctctttt tcgagtcttc catggcacct acttcaacaa

[1053] 1501 cttctgttca atagccaggc ttctggggac caagacgtgc aagcaggtct ttcagtttgc

[1054] 1561 agtcaaagaa tcactttatcc tgaagctgcc aacagatgag ctcatgaacc cctcacagaa

[1055] 1621 gaaaaaga aagcacagat tgtgggctgc acactgcagg aagattcagc tgaaaga

[1056] 1681 taactcttcc acaaagtgt acaactacca accctgcgac cacccagacc gcccctgtga

[1057] 1741 cagcacctgc ccctgcatca tgactcagaa tttctgtgag aagttctgcc agtgcaaccc

[1058] 1801 agactgtcag aatcgtttcc ctggctgtcg ctgtaagacc cagtgcaata ccaagcaatg

[1059] 1861 tccttgctat ctggcagtgc gagaatgtga ccctgacctg tgtctcacct gtggggcctc

[1060] 1921 agagcactgg gactgcaagg tggtttcctg taaaaactgc agcatccagc gtggacttaa

[1061] 1981 gaagcacctg ctgctggccc cctctgatgt ggccggatgg ggcaccttca taaaggagtc

[1062] 2041 tgtgcagaag aacgaattca tttctgaata ctgtggtgag ctcatctctc aggatgaggc

[1063] 2101 tgatcgacgc ggaaaggtct atgacaaata catgtccagc ttcctcttca acctcaataa

[1064] 2161 tgattttgta gtggatgcta ctcggaaagg aaacaaaatt cgatttgcaa atcattcagt

[1065] 2221 gaatcccaac tgttatgcca aagtggtcat ggtgaatgga gaccatcgga ttgggatctt

[1066] 2281 tgccaagagg gcaattcaag ctggcgaaga gctcttcttt gattacaggt acagccaagc

[1067] 2341 tgatgctctc aagtacgtgg ggatcgagag ggagaccgac gtcctttagc cctcccaggc

[1068] 2401 cccacggcag cacttatggt agcggcactg tcttggcttt cgtgctcaca ccactgctgc

[1069] 2461 tcgagtctcc tgcactgtgt ctcccacact gagaaacccc ccaacccact ccctctgtag

[1070] 2521 tgaggcctct gccatgtcca gagggcacaa aactgtctca atgagagggg agacagaggc

[1071] 2581 agctagggct tggtctccca ggacagagag ttacagaaat gggagactgt ttctctggcc

[1072] 2641 tcagaagaag cgagcacagg ctggggtgga tgacttatgc gtgatttcgt gtcggctccc

[1073] 2701 caggctgtgg cctcaggaat caacttaggc agttcccaac aagcgctagc ctgtaattgt

[1074] 2761 agctttccac atcaagagtc cttatgttat tgggatgcag gcaaacctct gtggtcctaa

[1075] 2821 gacctggaga ggacaggcta agtgaagtgt ggtccctgga gcctacaagt ggtctgggtt

[1076] 2881 agaggcgagc ctggcaggca gcacagactg aactcagagg tagacaggtc accttactac

[1077] 2941 ctcctccctc gtggcagggc tcaaactgaa aggtgtggg ttctaagtac aggcattcaa

[1078] 3001 ggctggggga aggaagcta cgccatcctt ccttagccag agggaga ccagccagat

[1079] 3061 gatagtagtt aaactgctaa gcttgggccc aggaggcttt gagaaagcct tctctgtgta

[1080] 3121 ctctggagat agatggaga gtgttttcag attcctggga acagacacca gtgctccagc

[1081] 3181 tcctccaaag ttctggctta gcagctgcag gcaagcatta tgctgctatt gaagaagcat

[1082] 3241 taggggtatg cctggcaggt gtgagcatcc tggctcgctg gatttgtggg tgttttcagg

[1083] 3301 ccttccattc cccatagagg caaggcccaa tggccagtgt tgcttatcgc ttcagggtag

[1084] 3361 gtgggcacag gcttggacta gagaggagaa agattggtgt aatctgcttt cctgtctgta

[1085] 3421 gtgcctgctg tttggaaagg gtgagttaga atatgttcca aggttggtga ggggctaaat

[1086] 3481 tgcacgcgtt taggctggca ccccgtgtgc agggcacact ggcagagggt atctgaagtg

[1087] 3541 ggagaagaag caggtagacc acctgtccca ggctgtggtg ccaccctctc tggcattcat

[1088] 3601 gcagagcaaa gcactttaac cattcttttt aaaaggtcta tagattgggg tagagtttgg

[1089] 3661 cctaaggtct ctagggtccc tgcctaaatc ccactcctga gggaggggga agaagagagg

[1090] 3721 gtgggagatt ctcctccagt cctgtctcat ctcctgggag aggcagacga gtgagtttca

[1091] 3781 cacagaagaa tttcatgtga atggggccag caagagctgc cctgtgtcca tggtgggtgt

[1092] 3841 gccgggctgg ctgggaacaa ggagcagtat gttgagtaga aagggtgtgg gcgggtatag

[1093] 3901 attggcctgg gagtgttaca gtagggagca ggcttctccc ttctttctgg gactcagagc

[1094] 3961 cccgcttct cccactccac ttgttgtccc atgaaggaag aagtggggtt cctcctgacc

[1095] 4021 cagctgcctc ttacggtttg gtatgggaca tgcacacaca ctcacatgct ctcactcacc

[1096] 4081 acactggagg gcacacacgt accccgcacc cagcaactcc tgacagaaag ctcctcccac

[1097] 4141 ccaaatgggc caggccccag catgatcctg aaatctgcat ccgccgtggt ttgtattcat

[1098] 4201 tgtgcatatc agggataccc tcaagctgga ctgtgggttc caaattactc atagaggaga

[1099] 4261 aaaccagaga aagatgaaga ggaggagtta ggtctatttg aaatgccagg ggctcgctgt

[1100] 4321 gaggaatagg tgaaaaaaa cttttcacca gcctttgaga gactagactg accccaccct

[1101] 4381 tccttcagtg agcagaatca ctgtggtcag tctcctgtcc cagcttcagt tcatgaatac

[1102] 4441 tcctgttcct ccagtttccc atcctttgtc cctgctgtcc cccactttta aagatgggtc

[1103] 4501 tcaacccctc cccaccacgt catgatggat ggggcaaggt ggtggggact aggggagcct

[1104] 4561 ggtatacatg cggcttcatt gccaataaat ttcatgcact ttaaagtcct gtggcttgtg

[1105] 4621 acctcttaat aaagtgttag aatccaaaaa aaaa (서열 번호 107)

[1106] RbAp48(등록 번호 NM_005610):

[1107] 1 gctcccattg gctgatgttg gcgcgaaggt gcgcgagtca gccctcgcgc tgggggcgca

[1108] 61 ggaaacaata gaggccgcgc gcacagagcg agctcttgca gcctccccgc ccctcccgca

[1109] 121 acgctcgacc ccaggattcc cccggctcgc ctgcccgcca tggccgacaa ggaagcagcc

[1110] 181 ttcgacgacg cagtggaaga acgagtgatc aacgaggaat acaaaatatg gaaaaagaac

[1111] 241 accccttttc tttatgattt ggtgatgacc catgctctgg agtggcccag cctaactgcc

[1112] 301 cagtggcttc cagatgtaac cagaccagaa gggaaagatt tcagcattca tcgacttgtc

[1113] 361 ctggggacac accatcgga tgacaacac catcttgtta tagccagtgt gcagctccct

[1114] 421 aatgatgatg ctcagtttga tgcgtcacac tacgacagtg agaaaggaga atttggaggt

[1115] 481 ttggttcag ttagtggaa aattgaaata gaatcaaga tcaccatga aggagaagta

[1116] 541 aacaggggcc gttatatgcc ccagaaccct tgtatcatcg haacaagac tccttccagt

[1117] 601 gatgttcttg ttttgacta tacaaacat ccttctaac cagatccttc tggagtgc

[1118] 661 aacccagact tgcgtccg tggacatcag aaggaggct atgggctttc ttggaaccca

[1119] 721 aatctcagtg ggcacttact tagtgctca gatgaccata ccatctgcct gtgggacatc

[1120] 781 agtgccgttc haaggagggg aaagtgta gatgcgaaga ccatctttac agggcatacg

[1121] 841 gcagtagtag aagatgtttc ctggcatcta ctccatgagt ctctgttgg gtcagttgct

[1122] 901 gatgatcaga aacttatgat ttgggatact cgttcaaaca attacktccaa accaagccac

[1123] 961 tcagttgatg ctcacactgc tgaagtgaac tgccttctt tcaatcctta tagtgagttc

[1124] 1021 attcttgcca caggatcagc tgacaagact gttgccttgt gggatctgag aaatctgaaa

[1125] 1081 cttaagttgc attcctttga gtcacataag gatgaaatat tccaggttca gtggtcacct

[1126] 1141 cacaatgaga ctatttagc ttccagtggt actgatcgca gactgaatgt ctgggattta

[1127] 1201 agtaaaattg gagaggaca atccccaga gatgcagaag acgggccacc agagttgttg

[1128] 1261 tttattcatg gtggtcatac tgccaagata tctgatttct cctggaatcc caatgaacct

[1129] 1321 tgggtgattt gttctgtatc agaagacaat atcatgcaag tgtggcaaat ggcagagaac

[1130] 1381 atttataatg atgaagaccc tgaaggaagc gtggatccag aaggacaagg gtcctagata

[1131] 1441 tgtctttact tgttgtgatt ttagactccc cttttttctt ctcaaccctg agagtgattt

[1132] 1501 aacactggtt ttgagacaga cttattcag ctatccctct atataatagg taccaccgat

[1133] 1561 aatgctatta gcccaaaccg tgggtgtttt ctaaatatta ataggggggc ttgattcaac

[1134] 1621 aaagccacag acttaacgtt gaaatttct tcaggaattt tctagtaacc caggtctaaa

[1135] 1681 gtagctacag aaaggggaat attatgtgtg attatttttc ttcttatgct ataccccaa

[1136] 1741 gtttttcaga ctcatttaag taaaggctag agtgagtaag gaatagagcc aaatgaggta

[1137] 1801 ggtgtctgag ccatgaagta taaatactga aagatgtcac ttttattcag gaaatagggg

[1138] 1861 gagattcaag tcatatagat tcctactcga aaatcttgac acctgacttt ccaggatgca

[1139] 1921 cattttcata cgtagaccag tttcctcttg gtttcttcag ttaagtcaaa acaacacgtt

[1140] 1981 cctcttccc catatattca tatattttg ctcgttagtg tatttcttga gctgttttca

[1141] 2041 tgttgttat ttcctgtctg tgaaatggtg tttttttttt tgttgttgg tttttttttt

[1142] 2101 ttttttttaa cttgggacca ccaagttgta aagatgtatg tttttacctg acagttatac

[1143] 2161 cacaggtaga ctgtcaagtt gagaagagtg aatcaataac ttgtatttgt tttaaaaatt

[1144] 2221 aaattaatcc ttgataagag ttgctttttt tttttaggag ttagtccttg accactagtt

[1145] 2281 tgatgccatc tccattttgg gtgacctgtt tcaccagcag gcctgttact ctccatgact

[1146] 2341 aactgtgtaa gtgcttaaaa tggaataaat tgcttttcta cataacccca tgctgatggg

[1147] 2401 ttttatttag tataaaacat ccatcaaaca ccagtctctg gcttctagaa gagtccttca

[1148] 2461 gatgacagtt gttgtccatg gtctttgact atcaagagca gaattaaatg taatagtccc

[1149] 2521 agagctgtag aaaagaactt tactccttcc cagggaaagt gaaagacata aaacactgaa

[1150] 2581 tcagaggtgg cacagattag tctttgataa ggtaacgttt ctttgaagtc tatctgtaga

[1151] 2641 gaactacatg gacttccaag agtgtcaaag gcagtgtggt agagagaatt taaggcaaga

[1152] 2701 tttaaatttg gaaaaggtgc ttgaaccttt tctcagaggt tttatttccc cagtatgttt

[1153] 2761 ttcactgggg cctttactta ggttagaaat aataggcttt gaaggcctct atcaccagat

[1154] 2821 gcaataacca gataaaattc ctgttttttc ccaatcgctt agttttttgt tgttgttgtt

[1155] 2881 ttttaactga gtagatcatt ctgacccaga actactttca tgaggtaaga tctttgggaa

[1156] 2941 aatctgaata gcgttaacca ttagattcaa atctcaaatg gtttcttttc aagtctagtt

[1157] 3001 gttttagagt atagtgagaa ataccttgac acaattttaa gagtaaacta tatgggtcag

[1158] 3061 catatccttg aacaaaaagt agactttgta aaagtattca tttaaattct aacactcgtg

[1159] 3121 gcacaaaaga atggaaattg taaacccatg taatggaaat tggctatctt tttgacccca

[1160] 3181 catgtgcccc tcaaaaatgt ttttggtttg ggtcaacaca aggcaagata cattctttaa

[1161] 3241 aatactccca gatgtgtcca tacattcatc cttcactcag tgcatatgtg agggttgttg

[1162] 3301 ctggaagaca ggaggctcat ctttcctttc cttggtgcat tgagatcagt atcaacagca

[1163] 3361 gatgaaatag aatccagcaa agagttgaca tgttctgcct ccggccaact ctagaatctt

[1164] 3421 tttaagcagg tcagccagta tttgcaactt ccacaggatg aattgcttgc caagtttctg

[1165] 3481 gcactcttgt ctggttggaa gagtacatcc aaagggtact tagtgatcct ttgctaagaa

[1166] 3541 gttttttgct gtttccgggt tacagatttg gccatatatt tctaaacagc ccctgtaaag

[1167] 3601 ttgaaagaaa aagtttataa cagtgaactt ctgaggttta gttactgcag gctttgttga

[1168] 3661 gaagagattg ttacagtgtg atttatggat gatcagggat gactttcccc tagcaaatat

[1169] 3721 ttggatgcct cctgtttgtc aaatagaatg aatggtgatg gtgatgggag ggatagttaa

[1170] 3781 acgttttctc tgctaggtta acttcttaca ggtataatta caatgcctga aattctgtag

[1171] 3841 tttcatttct ttggattagt cgttgtcttt tccagattgt acacaatctg atcaacacaa

[1172] 3901 aggtagttag tagatcatta acctcaattg caaggttata atttctcaaa cattaagcat

[1173] 3961 attatcagtc atgtggattc aaacacagta taagaaaatc ctcaaggctg ggtgtgatgg

[1174] 4021 cttatgcctg taatcccagc tacttagcag gctgaggcag gagtattgtt tgaacccagg

[1175] 4081 aggcagagtt gcagtgagcc aagatcgtgc cactactcca gcctgggcaa aatagcaaga

[1176] 4141 cccgaccccc catctctact aaaaagaaat ttaaaaaaat aaaatcctag aaaattagaa

[1177] 4201 aaagcaacaa tagttacttg tgggccaggc gcggtggttc acgcctgtaa tcccagcact

[1178] 4261 ttgagaggct gaggcacgtg gatcacaagg tcaggagttc aagaccagcc tggccaagat

[1179] 4321 ggtgaaaccc cgtttctact aaaatacaa aaactagctg gccgtggtgg catgctcctg

[1180] 4381 tagtcccagc tactcaggag gctgaggcag gaaaatcact tgaacccagg aggtggaggt

[1181] 4441 tgcagtgaac tgagaccgtg ccactgcact ccagcctggg tggcagagcg agactgtctc

[1182] 4501 aaaaaaaaaa gaaagttgtg aatttgatgt aagcttagga aatgaataaa atttataggc

[1183] 4561 atctgtataa tgtacaactt gacacggact ttcttttatc cttagtttct ttcacggact

[1184] 4621 ctagaacttt tatcagaata tactggtaaa acattggggg agggatcctg agtaggtgat

[1185] 4681 tggtcagaaa gatgccttca gttttgtcag tgtctaaaag ttaagtctgt ttaggccaag

[1186] 4741 catggtggct cacacctgaa atcccagcac tctgggaggc cgaggcaagt ggatcacaag

[1187] 4801 gtcaggagat gagaccatct tagccaacat ggtgaaaccc cgtctctact aaaatacaaa

[1188] 4861 aaaattagcc aggcgtggtg gtgcgtgcct ataatcccag ctacttggga ggctgaggca

[1189] 4921 ggggaatcgc ttgaacccgg gaggcagagg tcacgccact gcactccagc ctggcaacag 4981 agcaagactc cgtctcaaaa aaaaaaaaaa aaaaaaagag taagtctgtg taacatgaac

[1190] 5041 atctctgctt ccacccaaaa ccacagcctt tgaatattat ataaggaact taatggatag

[1191] 5101 atatgtttat tatttttgat agcacaactg ctttctctgc tattataagg aaaactgaga

[1192] 5161 atagcaggtg ggtagggtag gatgaggaaa caagatgccc aaagcctaga tgccacagaa

[1193] 5221 ttcatggtga taatcagggc atattttgag tcctactaga aacaaacatt ccaaatgaac

[1194] 5281 tctgaatgcc tgactcaggc gttttggagg tttgggttat ccccttgtca ttaggcacac

[1195] 5341 aagggttttt tgttgttttt gttttttggg tttttgtttt gttttgaggc agtctcactc

[1196] 5401 tgttgtacaa gctggagtgc tgtattgtga tcttgactca ctgcaacctc tgcctcctgg

[1197] 5461 ttcaagcgat tctcctgcct tggcctcctg agtagctggg attataagtg cctgccacta

[1198] 5521 tgcccggcta atttttgtat ttttagtgga gatggagttt tgccatgttg gccaggctgg

[1199] 5581 tcttgaactc ctgactccag gtgatccacc ctcctcagcc tcccaaagtg ctaggattac

[1200] 5641 aggcgtgagc caccccgtcc ggcctgtttt taaggcatta attagtattg ttaggaaagc

[1201] 5701 agtaacaatg caaacaccac tcttctcttc acaaagatca ccttgagact gtgtctccat 5761 tccacctgcc tgagaagtgg gagcatcagc ctgttccagg ctcttgggta gtagcatagc

[1202] 5821 cctttaaaaa gagagagcca ttttccatgt gtttttggat aagcacaatt tgaaaatcat

[1203] 5881 ttcccaaatc ctctttttgt ttttgattct aaggtaaaat tttccctaag ccctcccacc

[1204] 5941 atcccctcag ccagtattag atgagatttg tatagcagca gaaactgact tataagtaga

[1205] 6001 gagctcttca gcaagactga gccttagctg ttccatctct ttgttcttct gttgctggag

[1206] 6061 ttgcacccca tttcttaact gcctctggcg ttcttccatt tcctccagct gttcctgcat

[1207] 6121 gagatggcca agaacatttc taatgagcca aacaataaaa actcacattg tccactctta

[1208] 6181 cttataaaac acttttttgt tcattgttta atcttgatag cagtattgag gctggtattt

[1209] 6241 atatgatagg ttatgaaaca ggttcaaaga agttgtgtct tggaaaaaaa gtgacaatgc

[1210] 6301 ttttgaaaat gatgacgaaa aaggcatctt gtctgttaac cacagcttgc tttaatagaa

[1211] 6361 tcctgggagg gtgattggga ctttttagta ttacaacctt agtgtcattg aggaggattt

[1212] 6421 tggtctagtt agtgggctga gtttcatata cctctccctc catgtgcagg tttgttaaga

[1213] 6481 taattggtag tttttaataa tataaaatac ttaagttgaa atacaaaagt gtggcaacaa

[1214] 6541 ttttaaata ttggctagaa ttctaggaga gttacacaac tagtggaagt ccatgtttag

[1215] 6601 aaaataatg gcttgtttaa ggaaaagttt ttgtgtccaa agctccttaa agtcagagag

[1216] 6661 atttctacct ggtacttaac atcatatgga aattgatgct ttagtgaggg tgttggctat

[1217] 6721 cctattgcta atttcctgca tccttttttc ttctttattt ttgtatagag acagggtctc

[1218] 6781 gctatgttgc ccaggctggt cttgttcctg ggctcaagca gtcctcccgc ctcggtctcc

[1219] 6841 caaagtgctg ggattacagg tgtgagccac tgtgcccagc ttatcctttt ttcattacac

[1220] 6901 aaaaagactg aatttggtta gttctaagtt ggaagataaa gatggtatgc acaggaggcc

[1221] 6961 cttgggagcc ctcagataac tttctcattc ttccagaatc aggctgggat gcattctgta

[1222] 7021 aatttccct gcctaggatg tatacctgag gaataaggta aggaagatgt cagcaagtca

[1223] 7081 gtctctggtt tacctgctag ctggcatgga tccttaagga agcaggaggg agttgggaag

[1224] 7141 agaggaaggg gtgaagttgg tatcttttaa agcgagagtg atttacctc agattttgaa

[1225] 7201 gaatactaag gaatccagtt gttggggtac atgctattat tagaaggatc tagataattt

[1226] 7261 gtcctctgag tcatacttga cattgtacct gtggcacatc aatccgcact gtttgatact

[1227] 7321 ctggctgaat ctcagctttc accaacattg tcaaaggacc ttttttagtg cccagccatg

[1228] 7381 cctaagagtg tgtcatctga agagggaagc atctgcatac tgctgtcctg attgctcagt

[1229] 7441 cctcactacc taccagaccc gttggtaagg tacaaaagta catgcttgga aaagcagtct

[1230] 7501 gcaccaccag tgataagctg tgacagagtg gaacagcctc aatgaaatga aggaaggatt

[1231] 7561 gctacagtgg cattaaggat ggtctcttaa tcctgtgtta accactagat taactttaca

[1232] 7621 atcaactcaa aatccttcaa aggctttcca ctttctttag tggcattcag accccctcta

[1233] 7681 gtttgacccc tacctccaac ttgaacctct gttactcttc cgtatgaaca ttttcctcta

[1234] 7741 gccctggact actagtaccg aagtcactag tcacatagga ctcatttgaa atatgactag

[1235] 7801 tctcaattga gatgtaatgt aagtgtaaaa tacacagcag atttctaaga cagcacacaa

[1236] 7861 aatgtaaaat atgtcaaaaa tatttgatac tgattacatg ttgaaatata tgtgttgggt

[1237] 7921 taaataaaat gcattaaagt taa (sequence number 108)

[1238] Jarid2 (Registration No. NM_004973):

[1239] 1 tggatagcct ctctctcatt ggttaggggg cttggaaaaaa agagactcgg cgagccctcg

[1240] 61 ctgtggtgct gccgccgccg ccgccgccgc cgctggagtt gactcttctg ctcgcactgc

[1241] 121 tgctgcagca caaacgtgac ttccaacatt ttttattat ctttcccttt tcttttcca

[1242] 181

[1243] 241 aaaaaggggg gggagtgaag ggcgtcggtt tttttttgtg tgtgtgtgta tgtgtttcgg

[1244] 301

[1245] 361 tctttggctc tttttttttc cttcccaatt tcggatttat ttcaaggcga atctggcttt

[1246] 421 ggggaagag gaaaaagt cggattacaa gatcaaccac caccaacaac aataaaaacc

[1247] 481 accaggatat ttttttgcaa atttctgacg gctttaaatt catgaagcaa ttgtcccctt

[1248] 541 ttgcaatcag catttggatc tcagaatgag caaggaaaga cccaagaga atatcattca

[1249] 601 gaagaatac gatgacagtg atgggattcc gtggtcagaa gaacgggtgg tacgtaaagt

[1250] 661 cctttatttg tctctgaagg agttcaagaa ttcccagaag aggcagcatg cggaaggcat

[1251] 721 tgctgggagc ctgaaactg tgaatgggct ctttggtaat gaccagtcta agggattagg

[1252] 781 accagcatca gaacagtcag agaatgaaaa ggacgatgca tcccaagtgt cctccactag

[1253] 841 caacgatgtt agttcttcag attttgaaga agggccgtcg aggaaaggc ccaggctgca

[1254] 901 agcacaagg aagtttgctc agtctcagcc gatagtccc agcacaactc cagtaagat

[1255] 961 agtggagcca ttgctacccc ctccagctac tcagatatca gacctaccta aaggaagcc

[1256] 1021 tagacagaa gattttctta ccttctctg ctcttcgaggt tctcctgcgc tgcccacag

[1257] 1081 catggtgtat tttggaagct ctcaggatga ggaggaagtc gaggaggaag atgatgagac

[1258] 1141 agaagacgtc aaaacagcca ccacaatgc ttcatctca tgccagtcga cccccaggaa

[1259] 1201 aggaaaacc cacaacatg ttcacaacgg gcatgtttc aatggttcca gcaggtcac

[1260] 1261 agggagaag gaacctgttc aaaaaaaaaaaaaaagag gccactcccg aaaggaaa

[1261] 1321 gcacagcgat caccgggctg acagccgccg ggagcaggct tcagctaacc accccgcagc

[1262] 1381 ggccccctcc acgggttcct cggccaaggg gcttgctgcc acccatcacc accccccctct

[1263] 1441 gcatcggtcg gctcaggact tacggaaaca ggtttctaag gtaaacggag tcactcgaat

[1264] 1501 gtcatctctg ggtgcaggtg taaccagtgc caaaaagatg cgcgaggtca gaccttcacc

[1265] 1561 atccaaaact gtgaagtaca ctgccacggt gacgaagggg gctgtcacat acaccaaagc

[1266] 1621 caagagaa ctggtcaagg acaccaaacc caatcaccac aagcccagtt ccgctgtcaa

[1267] 1681 ccacacaatc tcagggaaaa ctgaaagtag caatgcaaaa acccgcaaac aggtgctatc

[1268] 1741 cctcgggggg gcgtccaagt ccactgggcc cgccgtcaat ggcctcaagg tcagtggcag

[1269] 1801 gttgaaccca aagtcatgca ctaaggaggt gggggggcgg cagctgcggg agggcctgca

[1270] 1861 gctgcgggag gggctggga actccaagag gagactgaga gaggcacacc aggcggagaa

[1271] 1921 gccgcagtcg ccccaaga agatgaagg ggcggctggc cccgccgag gccctgcag

[1272] 1981 gaaggccccg gccgagagag gtctgctgaa cggacacgtg aagaaggaag tgccggagcg

[1273] 2041 cagtctggag aggaatcggc cgaagcgggc cacggccgggg agagcacgc caggcagaca

[1274] 2101 agcacatggc aaggcggaca gcgctcctg tgaaatcgt tctacctcgc aaccggagtc

[1275] 2161 cgtgcacaag ccgcaggact cgggcaggc cgagaagggc ggcggcagg ccgggtgggc

[1276] 2221 ggccatggac gagatccccg tcctcaggcc ctccgccaag gagttccacg atccgctcat

[1277] 2281 ctacatcgag tcggtccgcg ctcaggtgga gaagttcgggg atgtgcaggg tgatcccccc

[1278] 2341 tccggactgg cggcccgagt gcaagctca cgatgagatg cggtttgtca cgcagattca

[1279] 2401 gcacatccac aagctgggcc ggcgctgggg cccacgtg cagcggctgg cctgcatcaa

[1280] 2461 gaagcacctc aaatctcagg gcatcaccat ggacgagctc ccgctcatag ggggctgtga

[1281] 2521 gctcgacctg gcctgctttt tccggctgat taatgagatg ggcggcatgc agcaagtgac

[1282] 2581 tgacctcaaa aaatggaaca aactagcaga catgctgcgc atccccagaa ctgcccagga

[1283] 2641 ccggctggcc aagctgcagg aggcctactg ccagtaccta ctctcctacg actccctgtc

[1284] 2701 cccagaggag caccggcggc tggagaagga ggtgctgatg gagagagaga tcctggagagaa

[1285] 2761 gcgcaagggg ccgctgggaag gccacacaga gaacgaccac cacaagttcc accctctgcc

[1286] 2821 ccgcttcgag cccaagaatg ggctcatcca cggcgtggcc cccaggaacg gcttccgcag

[1287] 2881 caagctcaag gaggtgggcc aggcccagtt gaagactggc cggcggcgac tcttcgctca

[1288] 2941 ggaaaaagaa gtggtcaagg aagaggga ggacaaaggc gtcctcaatg acttccacaa

[1289] 3001 gtgcatctat aagggaaggt ctgtttctct aacaactttt tatcgaacag cgagaatat

[1290] 3061 catgagcatg tgtttcagca aggagcctgc cccagccgaa atcgagcaag agtactggag

[1291] 3121

[1292] 3181 tcacggcagt ggattcccag taggaaaatc agaacccttt tcgaggcatg gatggaacct

[1293] 3241 caccgtcctc cccaataaca cagggtccat cctgcgtcac ctcggtgctc tgcctggagt

[1294] 3301 gactattccc tggctaaata ttggcatggt cttttctacc tcatgctggt ctcgagacca

[1295] 3361 aaatcacctt ccacatattg actacttaca cactggtgct gactgcattt ggtattgcat

[1296] 3421 tcctgctgag gaggaagaa agctggaaga tgtggtccac accctgctgc aagccaatgg

[1297] 3481 caccccaggg ctgcagatgc tggaaagcaa cgtcatgatc tccccggagg tgctgtgcaa

[1298] 3541 agaggggatc aaggtgcaca ggaccgtgca gcagagtggc cagtttgtcg tctgcttccc

[1299] 3601 gggatccttt gtgtccaaag tgtgctgtgg gtacagcgtg tctgaaaccg tgcactttgc

[1300] 3661

[1301] 3721 agctaagcca ttctccatgg agaagttact ctaccagatt gcacaagcag aagcaaaaaa

[1302] 3781 agaaaacggt cccactctca gtaccatctc agccctcctg gatgagctca gggatacaga

[1303] 3841 gctgcggcag cgcaggcagc tgttcgaggc tggcctccac tcctccgcac gctatggcag

[1304] 3901 ccacgatggc agcagcacgg tggcggacgg gaagaaaaag cctcgaaagt ggctgcagtt

[1305] 3961 ggagacgtca gagaggaggt gtcagatctg ccagcacctg tgctacctgt ccatggtggt

[1306] 4021 acaagagaac gaaaacgtcg tgttctgtct ggagtgtgct ctgcgccacg tggagaaaca

[1307] 4081 gaagtcctgc cgagggctga agttgatgta ccgctacgat gaggaacaga ttatcagtct

[1308] 4141 ggtcaatcag atctgcggca aagtgtctgg taaaaacggc agcattgaga actgtctcag

[1309] 4201 taaacccaca ccaaaaagag gtccccgcaa gagagcgaca gtggacgtgc ccccctcccg

[1310] 4261 tctgtcagcc tccagttcat ccaaaagtgc ttcgagctca tcatgaagat gccaacgccc

[1311] 4321 gtggtcgatt fathers tttttgtaat fathers tagtttggag tacttgctgt

[1312] 4381 aggattcaag ctgtctttgc actagctcta aagagattt tcttctggtt ttagagaact

[1313] 4441 aattttgttt tagcattaaa ctgttgaact tttttttgta cttagaaaac ctagatactg

[1314] 4501 cagtcagatt ttggaactg ccgtatagtc actgttttaa aaaccccgga ggggctgtat

[1315] 4561 taatttgtat tgccccatgg ctgacaaaag cctttttttt tggttttgat tttttttttt

[1316] 4621 ttgtaactgt tggggggaa aaggcttttt aacccatttt tgaagagggt gaagtttgga

[1317] 4681 gacaaattt aaaaaccatc agtcatgtga gcagattttt tagaaggat aggagacaca

[1318] 4741 cgcgcacaca cacacacaca cgaaacttga aatggctttg ctttggctgt cgtcttctgc

[1319] 4801 cgtgtgccag atgagcttgt gatctggga gccggggcac ccccgttttg tttctctggg

[1320] 4861 cggttgtggc agctgaaggc ggacgttgtt tcctaaccat aggtggacg aggagacggg

[1321] 4921 agcgagtggg ctctccacca gcacatcact atgcatctgt tccaggaaag aagaaaagcg

[1322] 4981 agcgaggaag acggaaaaga ctgcctgcct tggaggggtc acatgaggga gacctgtgcc

[1323] 5041 tgatttcatt aggaaatcca ttctgttatt ttttggtgct gttggctact ttatcaaaaa

[1324] 5101 acccttcaat agcatcctta agatttaaaa aaaaaaaaaa aaaaaaggaa aaaaaagtga

[1325] 5161 tggaagccgt aagtgcttct ttgtcatcga cgtgcaatct ttctaacatt ccatctccat

[1326] 5221 ctcaccgctt cttgtttgac accttcacaa gtcagcatta atctttcttt taaaacttgt

[1327] 5281 ttcatttatg atcatgtaga gagccactag gaggcctgca gttatttttg aatgtgaaaa

[1328] 5341 tgcatttgcg ttcatcttgt ctattttttc tcttcatgtt gtaacaaaaa ggaaaaaaga

[1329] 5401 aaaaaaaatc ccatcccttt tgtacatatg cctgtaaatt gttttaaata cttgagcctt

[1330] 5461 tttctcggtg gggggtgggg aggggggtga gaagacaaga tgaagaaaag ccttacattt

[1331] 5521 cagtttcttc atcggttgga ttggatgctt acagggtttt tcttgtaaca tttataagtg

[1332] 5581 ctgcttacat cactgaacaa caaaaaaa ataataatgg agtagctgtt gcccttcc

[1333] 5641 ggttgtgtgt acagtatgtg tggaataaaa aagggaaact gttttcacaa gctgttcttt

[1334] 5701 gtttcataat tggattcatc aatcccgtag ctacccatat tgcactgagc ttgccagtgg

[1335] 5761 tgactgccag gaacgtccta tgatccactt tgttggttgt tgttgcagaa gactgaactg

[1336] 5821 ttttggaata tttaacaatt acagaaacag tcaagtgttt tccaatgtgg ttgtccggtt

[1337] 5881 tctatggcct tgctgtgtac tttccctct ttgacagta aacttctgcc tatggcttac

[1338] 5941 agtttgacat ttaatttatt agcgctgctc tgcacccctc ccttgggagg gagacttcat

[1339] 6001 gtggtttatt gcgagtttt tgtttacttt tcaggtttgt actacaaggt ttaataataa

[1340] 6061 aaaaaagtt ttttggacat ttgtctgtct tgtggaaaaa aaaaaaaaa aa (서열 번호 109)

[1341] YY1(등록 번호 NM_003403):

[1342] 1 agggcgaacg ggcgagtggc agcgaggcgg ggcgggctga ggccagcgcg gaagtctcgc

[1343] 61 gaggccgggc ccgagcagag tgtggcggcg gcggcgagat ctgggctcgg gttgaggagt

[1344] 121 tggtatttgt gtggaaggag gcggaggcgc aggaggagg gggaagcgga gcgccggccc

[1345] 181 ggaggggcggg aggaggcggcg gccaggggcgg gcggttgcgg cgaggcgggg cgaggcgggg

[1346] 241 agccgagacg agcagcggcc gagcgagcgc gggcgcgggc gcaccgaggc gagggaggc

[1347] 301 gggaagcccc gccgccgccg cggcgccccc cccttccccc gccgccccc ccctctcccc

[1348] 361 ccgcccgctc gccgccttcc tccctctgcc ttccttcccc acggccggcc gcctcctcgc

[1349] 421 ccgcccgccc gcagccgagg agccgaggcc gccgcggccg tggcggcgga gccctcagcc

[1350] 481 atggcctcgg gcgacaccct ctacatcgcc acggacggct cggagatgcc ggccgagatc

[1351] 541 gtggagctgc acgagatcga ggtggagacc atcccggtgg agaccatcga gaccacagtg

[1352] 601 gtgggcgagg aggaggagga ggacgacgac gacgaggacg gcggcggtgg cgaccacggc

[1353] 661 ggcgggggcg gccacgggca cgccggccac caccaccacc accatcacca ccaccaccac

[1354] 721 ccgcccatga tcgctctgca gccgctggtc accgacgacc cgacccaggt gcaccaccac

[1355] 781 caggaggtga tcctggtgca gacgcgcgag gaggtggtgg gcggcgacga ctcggacggg

[1356] 841 ctgcgcgccg aggacggctt cgaggatcag attctcatcc cggtgcccgc gccggccggc

[1357] 901 ggcgacgacg actacattga acaaacgctg gtcaccgtgg cggcggccgg caagagcggc

[1358] 961 ggcggcggct cgtcgtcgtc gggaggcggc cgcgtcaaga agggcggcgg caagaagagc

[1359] 1021 ggcaagaaga gttacctcag cggcggggcc ggcgcggcgg gcggcggcgg cgccgacccg

[1360] 1081 ggcaacaaga agtgggagca gaagcaggtg cagatcaaga ccctggaggg cgagttctcg

[1361] 1141 gtcaccatgt ggtcctcaga tgaaaaaaaa gatattgacc atgagacagt ggttgaagaa

[1362] 1201 cagatcattg gagagaactc acctcctgat tattcagaat atatgacagg aaagaaactt

[1363] 1261 cctcctggag gaatacctgg cattgacctc tcagatccca aacaactggc agaatttgct

[1364] 1321 agaatgaagc caagaaaaat taaagaagat gatgctccaa gaacaatagc ttgccctcat

[1365] 1381 aaaggctgca caaagatgtt cagggataac tcggccatga gaaaacatct gcacacccac

[1366] 1441 ggtcccagag tccacgtctg tgcagaatgt ggcaaagctt ttgttgagag ttcaaaacta

[1367] 1501 aaacgacacc aactggttca tactggagag aagccctttc agtgcacgtt cgaaggctgt

[1368] 1561 gggaaacgct tttcactgga cttcaatttg cgcacacatg tgcgaatcca taccggagac

[1369] 1621 aggccctatg tgtgcccctt cgatggttgt aataagaagt ttgctcagtc aactaacctg

[1370] 1681 aaatctcaca tcttaacaca tgctaaggcc aaaaacaacc agtgaaaaga agagagaaga

[1371] 1741 cccttctcga ccacgggaag catcttccag aagtgtgatt gggaataaat atgcctctcc

[1372] 1801 ttgtatatt atttctagga agaatttaa aaatgaatcc tacacaccta agggacatgt

[1373] 1861 tttgataag tagtaaaat taaaaaaaaaactttact aagatgacat tgctaagg

[1374] 1921 cttacttg ctctgtaatc tcgtttcaa aacacagtgt tttgtaag tgtgtccca

[1375] 1981 acaggaggac attcatgaa cttcgcatca aagacaatt ctttatacaa cagtgctaaa

[1376] 2041 aatgggactt ctttcacat tcttataat atgaagctca cctgttgctt acaattttt

[1377] 2101 taatttgta tttccaagt gtgcatattg tacacttt tgggatatg cttagtaatg

[1378] 2161 ctacgtgtga tttctgga ggttgataac tttgcttgca gtagattttc tttaaagaa

[1379] 2221 tgggcagtta catgcatact tcaaagtat tttctgtaa aaaaaaaaa gttatatagg

[1380] 2281 ttttgttgc tatctttatt ttggttgtat tctttgatgt taacacattt tgtataattg

[1381] 2341 tatcgtatag ctgtattgaa tcatgtagta tcaatatta gatgtgattt atagtgtta

[1382] 2401 atcaatttaa acccatttta gtcacttttt ttttccaaaa aaatactgcc agatgctgat

[1383] 2461 gttcagtgta atttctttgc ctgttcagtt acagaaagtg gtgctcagtt gtagaatgta

[1384] 2521 ttgtaccttt taacacctga tgtgtacatc ccatgtaaca gaaagggcaa caataaaata

[1385] 2581 gcaatcctaa agcaagaata tggcagaaca agatctgtaa gcacagtctt attttctttt

[1386] 2641 gttgtccaga atacttataa ttcttgagcc tcccagaaat tggaagctaa ataaagcaac

[1387] 2701 tcaagtttcc tttattttgc actcaattac agtgattatt gatgaaagcg atgcatggat

[1388] 2761 attttaatac ttcctacatg tcctgacttc tgaaagagag taggtaacag gcatcccgag

[1389] 2821 ttcaggaact acctcagaac accccaggcc aggttggtca taggctgtga tttagcccc

[1390] 2881 cggcaagtgt gagtgaagca tctgtaccac cgcgcaggct gagcgcctgc gcagggtaag

[1391] 2941 gtgccacctg gcagtggggc acacagagg aagaccaggc ctgtccatca gccggctgcc

[1392] 3001 ttcagaggca gctccagcag gaccttggct tgtctgacag gaaatgcttg tggtcgttgg

[1393] 3061 ttatttggtt tgagagccct tgttcctcca tctagtggag tccttattaa atgctagcaa

[1394] 3121 tgtggcaatt gagtgccagt agcttaattt catgtttct (서열 번호 110)

[1395] CBX2(등록 번호 NM_005189):

[1396] 1 ggcggtccgg gcgggtgact ggcggcgggc gccgcggtg ggctggctgc cgggcagcat

[1397] 61 ggaggagctg agcagcgtgg gcgagcaggt cttcgccgcc gagtgcatcc tgagcaagcg

[1398] 121 gctccgcaag ggcaagctgg agtacctggt caagtggcgc ggctggtcct ccaaacataa

[1399] 181 cagctgggag ccggaggaga acatcctgga cccgaggctg ctcctggcct tccagaagaa

[1400] 241 ggaacatgag aaggaggtgc agaaccggaa gagaggcaag aggccgagag gccggccaag

[1401] 301 gaagctcact gccatgtcct cctgcagccg gcgctccaag ctcaaggaac ccgatgctcc

[1402] 361 ctccaaatcc aagtccagca gttcctcctc ttcctccacg tcatcctcct cttcctcaga

[1403] 421 tgaagaggat gacagtgact tagatgctaa gaggggtccc cggggccgcg agaccacc

[1404] 481 agtgccgcag aagaaggccc agatcctggt ggccaaaccc gagctgaagg atcccatccg

[1405] 541 gaaagcgg ggacgaaagc ccctgccccc agagcaaaag gcaacccgaa gacccgtgag

[1406] 601 cctggccaag gtgctgaaga ccgccccggaa ggatctgggg gccccggcca gcaagctgcc

[1407] 661 ccctccactc agcgcccccg ttgcaggcct ggcagctctg aaggcccacg ccaaggaggc

[1408] 721 ctgtggcggc cccagtgcca tggccacccc agagaacctg gccagcctaa tgaagggcat

[1409] 781 ggccagtagc cccggccggg gtggcatcag ctggcagagc tccatcgtgc actacatgaa

[1410] 841 ccggatgacc cagagccagg cccaggctgc cagcaggttg gcgctgaagg cccaggccac

[1411] 901 caacaagtgc ggcctcgggc tggacctgaa ggtgaggacg caaaagggg agctgggaat

[1412] 961 gagccctcca ggaagcaaaa tcccgaaggc ccccagcggt ggggctgtgg agcagaaagt

[1413] 1021 ggggaacaca gggggccccc cgcacaccca tggtgccagc agggtgcctg ctgggtgccc

[1414] 1081 aggcccccag ccagcaccca cccaggagct gagcctccag gtcttggact tgcagagtgt

[1415] 1141 caagaatggc atgcccgggg tgggtctcct tgcccgccac gccaccgcca ccaagggtgt

[1416] 1201 cccggccacc aacccagccc ctgggaaggg cactgggagt ggcctcattg gggccagcgg

[1417] 1261 ggccaccatg cccaccgaca caagcaaaag tgagaagctg gcttccagag cagtggcgcc

[1418] 1321 acccacccct gccagcaaga gggactgtgt caagggcagt gctaccccca gtgggcagga

[1419] 1381 gagccgcaca gcccccggag aagcccgcaa ggcggccaca ctgccagaga tgagcgcagg

[1420] 1441 tgaggagagt agcagctcgg actccgaccc cgactccgcc tcgccgccca gcactggaca

[1421] 1501 gaacccgtca gtgtccgttc agaccagcca ggactggaag cccacccgca gcctcatcga

[1422] 1561 gcacgtattt gtcaccgacg tcactgccaa cctcatcacc gtcacagtga aggagtctcc

[1423] 1621 caccagcgtg ggcttcttca acctgaggca ttactgaagc cccggcgcca ccagctgcgc

[1424] 1681 ggtcttactc cccttccctg cctatggtgt cgcttggcta agtgactccc agcccaagcc

[1425] 1741 ccctcaagag tctgggtcgg gggaggag gtgggtggcc tccttgatgg gcaggcttgg

[1426] 1801 aagggacttc tcccgcaccc cactctgtcc caggacatag ggcagggggc ctcactgcct

[1427] 1861 tgttggtctc caccttgttc ctacctctgc aggcctcttt gctctcccct cttgcctcag

[1428] 1921 gaaacccggt ggcacctgtg gctccaggtg actgtcttga acagagcggg cttcttcatg

[1429] 1981 gctgcgttgt tgctgagttt gaactgctcc tccctggcct gcgtgactga atcacagctt

[1430] 2041 tggtccctgt cttgcagggg ctgaggtgtc aggagggac ttctggccca ccttgccttc

[1431] 2101 agccctggag tgggcagaga gtattgtggg gaggcatggc cagtgggact agtgttccct

[1432] 2161 ccatctggcc acagcttttg ggagatgggg tgggcagggg tggtcctggc tggcattgcc

[1433] 2221 tgagccggca gtgatgaagt ggggagcttg cccttgacag gtgggggctg gctggggcct

[1434] 2281 taatgtgaaa agcagtggc aggcagctgg agtagcggcccagcagc cctaaaaggc

[1435] 2341 tgccttcatg gccatctagc cccagttcag ggcagcatcc atagcccaca agccagcgtg

[1436] 2401 ggtggggcgg gggtggtccc acagctgggt tccacctgaa gagcctccgt gcctcggagc

[1437] 2461 aggagaggca ggctatggct gccaccctcc ctcctgcctg tgtcccagtg agaactgacc

[1438] 2521 tgagtcccct tccaaaccca gacccacctc ctgccccagg cccactgaag catgttccat

[1439] 2581 ttctaaaaag cccagagttc agtgtgtccc aaggaaaacc caaagtggag gtgctcaggt

[1440] 2641 ccaggggagt ccagtgggca ggacccttgg caggcaagcc cctcccttca ctcccaggac

[1441] 2701 ctaccttctg ctagtaaagg actggcttca ttctaattat ggcccacaga ctgccccgga

[1442] 2761 gacctggagg acagcagtgc tggcacttgg gtgtccatgg gcccgtctgc cggctctgcc

[1443] 2821 tgtgctgcaa gtgttggccg tgggtccagc caacaactcc ctacgtcctg tgtggggccc

[1444] 2881 tgcccaagtg gatgaggcat tccttgagga gtatcatttt ccctgacaat ccccatcacc

[1445] 2941 tttaggggtt ccctgcttgg ctcctttcca gctgaaaaac tagacctgtg ccattgggga

[1446] 3001 agctggacaa agtctagggg gcccgcctgg tagagggtcc cgggaagctg gatctgtcag

[1447] 3061 cctcggccct gaggcccctg ttaactcaag actgtgagct gcctctaggt ggtcacgtct

[1448] 3121 gggagctagc ttgtatggct tctgaccagt atcaggattt ctgttctgag agcagcgtgg

[1449] 3181 gcagcaaggc agggcagccc agaggtggca gcggcaggca atctggtcac taggtctttg

[1450] 3241 tgatgccaaa aataaaagag ggtggggtgg gtgctttctg ttcctctgat tggatggagt

[1451] 3301 ccgccagcag gcatggggct acattccagt gcctgactat agggaggcac tcctgattcc

[1452] 3361 atggagcagc ccggactttg agaatgggct ctggtttgcg gggggcaggc gtaccagact

[1453] 3421 gcaagacccc ccagtacctc accgtgccaa ataggaagag gtggccttgg tgtagccaaa

[1454] 3481 tggatctttt taacagtgtg cctttgggga gggacccatg tccatggctt cgttgagggc

[1455] 3541 catccatatg ccagctgggg gccagcccac agtggccata ttggctgcag caggaatggt

[1456] 3601 gcccacctcg gcgaattgaa gggctaagag tcccagatag ctaggccaga gctggaagca

[1457] 3661 gacagtaagg ggaagagctg ctcccacagg agagggagag attccagctc actgcgcagc

[1458] 3721 ctgggaggag gcgtggatcc tggcacgctg agcctcaggc accagcctcc ctgtgctcga

[1459] 3781 cagcaaagtc ttgactcctt cctgctgagc actgtgctac cttcactgct ccaaagccag

[1460] 3841 actaacagct ctccaagccc ttggggtgac tcggcttcca ggagctgttg gagaaatgag

[1461] 3901 gatgtctgtc cctgtctgcc tgggcaggcc agattcctcc ccagcagccg ggtctctcca

[1462] 3961 gaccctgatt cggtgccttt ctgtttacca gctacttcaa tcccaaagtt tgaatctgca

[1463] 4021 gataccttac tcccagccac tttgccttct tactgtgttg tgtgtttttc ctggtgcttc

[1464] 4081 aagagcgtgt gcagggcaag tgccgtcact gggaactgca ccagatgctc agacttggtt

[1465] 4141 gtcttatgtt taccaataaa taaaagtaga ctttttctat ttttatttgc tgctatttgt

[1466] 4201 gtgtgtgttt gtgtttgtgt agctaggtat ctggcacttc tgacgatgca ttgttgcttt

[1467] 4261 tttcc (서열 번호 111)

[1468] CBX4(등록 번호 NM_003655):

[1469] 1 agccggggcg ggcgcgggca gcggcgggcc ggccgggctg tgcggggcga gcggcggcgg

[1470] 61 cggcgggggc gcttcggccg gggcggcagc tgggcgccgg cgggagctag cagcgtctgc

[1471] 121 agccgcgccg gccgccagcg ccccggcgcg ctccggctcg gccatggagc tgccagctgt

[1472] 181 tggcgagcac gtcttcgcgg tggagagcat cgagaagaag cggatccgca agggcagagt

[1473] 241 ggagtatctg gtgaaatgga gaggctggtc gcccaaatat aacacgtggg aaccggagga

[1474] 301 gaacatcctg gaccccaggc tgctgatcgc cttccagaac agggacggc aggagcagct

[1475] 361 gatgggatat cggaagagag ggccgaagcc caaaccgcta gtggtgcagg tgcctacctt

[1476] 421 tgcccgtcgt tccaatgtcc tgaccggcct ccaggactcc tccactgaca accgtgccaa

[1477] 481 gctggatttg ggcgcgcagg ggagggcca ggggcatcag tacgagctca acagcaaga

[1478] 541 gcaccaccag taccagccgc acagcaagga gcggggcgggc aagcccccgc cgccggggcaa

[1479] 601 gagcggcaag tactactac agctcaacag caagaagcac cacccctacc agcccgaccc

[1480] 661 caaaatgtac gacctgcagt accagggcgg ccacaaggag gcgcccagcc ccacctgccc

[1481] 721 ggacctgggg gccaagagcc acccgcccga caagtgggcg caaggtgcgg gggccaaagg

[1482] 781 ctacctgggg gcggtgaagc ccctggccgg tgcggcgggt gctccaggca aaggctccga

[1483] 841 gaagggcccc cccaacgga tgatgccggc ccccaaagag gctgtgacgg gcaacgggat

[1484] 901 tgggggcaag atgaagatag tcaagaacaa gaacaagaac ggacgcatcg tgatcgtgat

[1485] 961 gagcaaatac atggagaacg gcatgcaggc ggtgaagatc aagtccggcg aggtggcaga

[1486] 1021 gggggaggct cgctccccca gccacaagaa gcgggcagcc gacgagcgcc accctcctgc

[1487] 1081 cgacaggact tttaaaaagg cggcgggcgc agaggagaag aaggtggagg cgccgcccaa

[1488] 1141 gaggagggag gaggaggtgt ccggggttag cgatccgcag ccccaggatg ccggctcccg

[1489] 1201 caagctgtcc ccgaccaagg aggcctttgg agagcagccc ctgcagctca ccaccaagcc

[1490] 1261 cgacctgctt gcctgggacc cggcccggaa cacgcacccg ccctcacacc acccgcaccc

[1491] 1321 gcacccccat caccaccacc accaccacca ccaccaccac cacgccgtcg gcctgaatct

[1492] 1381 ctcccacgtg cgcaagcgct gcctctccga gacccacggc gagcgcgagc cctgcaagaa

[1493] 1441 gcggctgact gcgcgcagca tcagcacccc cacctgcctg gggggcagcc cagccgctga

[1494] 1501 gcgcccggcc gacctgccac cagccgccgc cctcccgcag cccgaggtca tcctgctaga

[1495] 1561 ctcagacctg gatgaaccca tagacttgcg ctgcgtcaag acgcgcagcg aggccgggga

[1496] 1621 gccgcccagc tccctccagg tgaagcccga gacaccggcg tcggcggcgg tggcggtggc

[1497] 1681 ggcggcagcg gcacccacca cgacggcgga gaagcctcca gccgaggccc aggacgaacc

[1498] 1741 tgcagagtcg ctgagcgagt tcaagccctt ctttgggaat ataattatca ccgacgtcac

[1499] 1801 cgcgaactgc ctcaccgtta ctttcaagga gtacgtgacg gtgtagccgg agggcgtcgg

[1500] 1861 aaggggaagc gccattcccg cgggggggcg gggagctgag cacctggggc ctcggggcgg

[1501] 1921 gctcccctct cgccaacccg ccaaccgcga gagacccagg ctggccccca gggtgaggac

[1502] 1981 gcccggagcg gaggtaacca tgttccccct gcggcggctg tcagacctgg gcggaggccc

[1503] 2041 cttccacgcg gtgccggcgg ggctcgccct ctcctgccct tccccgctgg agatggaccc

[1504] 2101 ccggaacgga cagggcagct ctgcgccccgg cctcagagtt ctagtattat attttaaccg

[1505] 2161 tgctaacttg tcaagtgctg actctactcc cgtttgtacg tggtgttat attgaaatgt

[1506] 2221 attgtttgag ctcaaaaggc ccgaccaccc cccttcgggc tgctatatat atatttattt

[1507] 2281 gtaggtattt atatattgaa atataaaaac ctagatttt ggagtttcct ctagatcatg

[1508] 2341 ttatattcta tatcagacaa actattttct tttgaccttt cttcccctcc atccagtatt

[1509] 2401 tcggttgatt tcattttctc ccctctcttc cccttccacg aactgcaata ccagtaacct

[1510] 2461 tggtatat tttttgatac tgtacacatg gatgtcttgt ttctatgtgc aaaaaaaaa

[1511] 2521 aaaaaaaaaa gtttgttaaa aggctacacg agctctctag aaactgctgc tactagaaat

[1512] 2581 gtctaacta taagcttcca actattacct gcttgaatgt aaatattaaa tggagatgtt

[1513] 2641 gaaggtgcaa aaaaa (서열 보리 112)

[1514] CBX6 (registration number NM_014292):

[1515] 1 gtgacggccc gcagctggaa cgcgagcgcg cgccccgccg cgctcccgcc cgccggggcc

[1516] 61 tgggcgctgc ggcgcgtgcg cgagcggtgc cgcaccggcc gcgggcgcag ggagtattat

[1517] 121 gggctgtggg tgccgctgag caagatggag ctgtctgcag tgggcgagcg ggtcttcgcg

[1518] 181 gccgaatcca tcatcaaacg gcggatccga aagggacgca tcgagtacct ggtgaaatgg

[1519] 241 aaggggtggg cgatcaagta cagcacttgg gagcccgagg agaacatcct ggactcgcgg

[1520] 301 ctcattgcag ccttcgaaca aaaggagagg gagcgtgagc tgtatgggcc caagaagagg

[1521] 361 ggacccaaac ccaaaacttt cctcctgaag gcgcgggccc aggccgaggc cctccgcatc

[1522] 421 agtgatgtgc atttctctgt caagccgagc gccagtgcct cctcgcccaa gctgcactcc

[1523] 481 agcgcagccg tgcaccggct caagaaggac atccgccgct gccaccgtat gtcccgccgt

[1524] 541 cccctgcccc gcccggaccc gcaggggggc agccccggac tgcgcccgcc catttcgccc

[1525] 601 ttctcggaga cggtgcgcat catcaaccgc aaggtgaagc cgcgggagcc caagcggaac

[1526] 661 cgcatcatcc tgaacctgaa ggtgatcgac aagggcgctg gcggcggggg cgccgggcag

[1527] 721 ggggccgggg cgctggcccg ccccaaagtc ccctcgcgga accgcgttat aggcaagagc

[1528] 781 aagaagttca gcgagagcgt cctgcgtaca cagatccgcc acatgaagtt cggcgccttt

[1529] 841 gcgctgtaca agcctccgcc cgcccccctg gtagccccgt cccccggcaa ggctgaggcc

[1530] 901 tcagccccgg gccctgggct acttctggcc gcccccgccg ccccctacga cgcccgcagc

[1531] 961 tctggctcct ccggctgccc ctcgcctaca ccacagtcct ctgaccccga cgacacgccc

[1532] 1021 cccaagctcc tccccgagac cgtgagccca tccgccccca gctggcgcga gccggaggtg

[1533] 1081 ctcgacctgt ccctccctcc cgagtcggca gccaccagca agcgggcacc gcctgaggtc

[1534] 1141 acagctgctg ccggcccggc acctcccacg gcccctgagc ccgccggtgc ctcctccgag

[1535] 1201 cccgaggctg gggactggcg ccccgagatg tcaccctgct ccaatgtggt cgtcaccgat

[1536] 1261 gtcaccagca acctcctgac ggtcacaatc aaaggaattct gcaaccctga ggatttcgag

[1537] 1321 aaggtggctg ctggggtagc aggcgccgct gggggcggtg gcagcattgg ggcgagcaag

[1538] 1381 tgaggggct ccaccaagga ggggggcttg ggggggccct cctgccccgaa gtcatactct

[1539] 1441 tgctcccacc ccacccttgc ccccagccct ctctccctgt gctttgcttg tctcaaatgg

[1540] 1501 ctcggtgttg acccagggat ggggctgggt agttggggtc ccagaaagcc gggggtaggg

[1541] 1561 gccaccctgg aatggggcag gggaagggca caccccctgc ccatgcatgg tagcccactg

[1542] 1621 ggtggtttct ggaaagccct agaaactag gttcctctgc cccttccaca tcccacctgt

[1543] 1681 ctctctagct tgcttcctgc tctcctgtgc ggcgtctgat ttctcggtgc taacctggca

[1544] 1741 gctgtggggc ccttaggagc cccccaccga gggtggacac agtccctttc cttcctgcag

[1545] 1801 atgcctaggc aggaggaggg cttcctgcct gtttggcaaa gtcccaggca gaggccaagg

[1546] 1861 atgaggcctg actcggctcc tccctccaca tcagccaggg catcagaagt tgggccaggg

[1547] 1921 cggggtcttc cctgctcgat tttggacgag gcctaagtag accccctatg ccctgcccca

[1548] 1981 gccctggctc tttcctaacc ccctcaacgg tgggaggac tggcagaggg tgcgcctggc

[1549] 2041 cacagcctcc ccgcatctaa aggccccttc agttcttgac caaaggtgct acgagaacct

[1550] 2101 gccgtggaaa cttccagttg tgcgtctgcc ccactcgctg tgtttgtccg tgggttcata

[1551] 2161 catgcattgg gtgctaggcc ccaggctgcc gggtggcacc ctttacagtt cctttgaaca

[1552] 2221 ggggcattga aggcctggac tgcctctcgc ctcagtaggc ctggggacca ggcttgggtc

[1553] 2281 tggaggtttg ctgtggaagt caccaggcct cccctcctgg cccaggtgtg ctgggggcac

[1554] 2341 cgtgcccccc acccccctgc cctcctcagg gtggtcagcc caacctgtcg gaccttcact

[1555] 2401 tcacatcatg gtggggaccg agatagagag ggagacccca ttccaagctc cctcttcctc

[1556] 2461 cgggtgtttg gggaggatgc tgaagaatcc attcccgagg gcctcccggc ttgtcccagc

[1557] 2521 ccctcttttg cttctgacca cggaggcttt ctcacagccc agcctgcctg aagcaaagga

[1558] 2581 ggctcccgtg tcctgggcag cttctgtttc cctctgctgc ctgggagctg aggcacccgt

[1559] 2641 gccagtggca gaggccacag ccccagcctt aggccaggcc ctgggagggc aggcaggcaa

[1560] 2701 aggggagacc agagggtctg tgttctccag gagaatgagg gtgttggtcc cagaattggg

[1561] 2761 accggggccc cgctggccag ccctgggcca cttcccgggt ctccattgtg cgtgggtggc

[1562] 2821 gtgttccagg cgtggctgga gctggcttcc tggctgtgct gccatgggcc cctccctcag

[1563] 2881 aagcacgttg gcaggaggcc gatcagaacc ctagcgcctt tggtcctaag aatgggaggc

[1564] 2941 tgccttcctt cccaatctcc ctgccagggc ccacagcgtg gccctagccc tcccctcccc

[1565] 3001 gggatgtaga acggggaccc tcgcagggtt ggggcggggg ctgatactcc tcggcccctc

[1566] 3061 cctaccctgc cctgtgtgtt ggctttgtgg ccgtccaagt gccaattggc ttttcgccca

[1567] 3121 aataagggct ggtatttctc ctctgtcctt ggaggtgatt tccccctgac cccctccccc

[1568] 3181 aggtgagtga ccacctgggt gccagttaca ggtgtttcca gagaccatag aaatgtgttt

[1569] 3241 tcctgagagt tcgtgtcatt cgtgactttt ttgtaaagaa gttgtgtttt cagaggtgat

[1570] 3301 tttatgacag gaaagtgaaa gaattagttt tgcaaaaaaa caaaaacaaa aaaagaggaa

[1571] 3361 aaaaaaaaga aatagaaaaa aatattgtgg gattcctatg ggggggtggc gggggagaaa

[1572] 3421 gagctattta agaaaaaata gtaacgcagt gattgcacag gtgaggtggc aatgtcagga

[1573] 3481 tggggcggag gcctgggccc agctggcagg tcccctggca tcgcaggcac tgtggagagg

[1574] 3541 gcctggaccc agatctccac acccgtgctt gctcaaaggg aaggacaaca gcgggccccc

[1575] 3601 gggagctac ccaagctgca ggtcccggca agctgaggtt tgggagggtg ggggttgtca

[1576] 3661 ctggtgattt tctccagggg gctggtgagt gggcagtttg gtttcttgcc cccttctgtt

[1577] 3721 cctttcccag ttgttgggcc atctggtccc caccaccgcc accctatggg ggagacctcc

[1578] 3781 ctccccacgg gtcaccctaa agcccacaac ctctctgagc ctccctggcc tgaaagggga

[1579] 3841 tgcaggcttc aggaggcaag aagctgggcc cctgggggtg gctggggaga gggaatgcat

[1580] 3901 ttcccttgcc acaggtggtc tgcttctgct ggcctgagct ccaagtggag cagcccgggc

[1581] 3961 cagccttggt gcatgaagag gcaccaggca caccgccttg aggtgggcag tgcccatggg

[1582] 4021 ggcccgagtg gatgggaccg agggtgagtg gagcctcctt cctcccctct ctagtacccc

[1583] 4081 cgcctcccac acacttgcac ggatcggcct cccttggggag atcagcctcc atgggcccct

[1584] 4141 cgtccaccct tgctgctttc catttgccta attackc agaagttgca atctggtttg

[1585] 4201 ctttattttt gtatgtgaaa taacccccaa agcccaatct cctcctacgt tcaatattgg

[1586] 4261 ttggggcatc cgtcatctcc ccttaagtgc gccccctccc cacccaagta tcataggaaa

[1587] 4321 ccggtgaggt ctggtgtctc tggtttgaga cggtaagttg ggacccatcc ctgtctgggt

[1588] 4381 gcccactctg acctttagtt tgcccttctg tgaaatgggt gtattgggta gcaagccctc

[1589] 4441 ttcagaaagc gctgctggtg tcagagcagc tgcccagtac caggtggggg gtcaaggttg

[1590] 4501 ctggtactgg ggcccccagc tgcccacaac ccctctttgt tctcaccctg caaaggggtc

[1591] 4561 aaggtcaaaa tgagcctcat ccttcctatg atctgggaag aggtgatgat caagtcccca

[1592] 4621 acttcagtgt gaggtggaca gagttggggg gatggcccct ttttgaagag gtgaaaatgg

[1593] 4681 ttttggagaa gcgcagctgc ttcactgggg gaatgcggca gggactgggg cccaggatgc

[1594] 4741 tttggcctat ggggaaaagc cctttaaaag gcagggccca ggccctggag ccagcacaag

[1595] 4801 actggcctcg agcccctgag ccaggaggtc ctggaggaga gccaggccgg tgggcccgcc

[1596] 4861 caaggctgga gggtcagccc caacagggag ctgggttggc cagggggctg gactgctacc

[1597] 4921 agcctctctg gcctatgggg acccaagagg acacatcccc cttttgccca ctcttctgtg

[1598] 4981 tcattttgtt gttttggttt gtggtggttt ttcttttttc ttttgttttt cttttttctt

[1599] 5041 tctttctttt tttttttttt tttttttttt tttgcacttc gcccacacag gacagtggag

[1600] 5101 ccccacctgg tcagttccac ttccgggctc ccatgcactt gcccaaggcg gcctctttgg

[1601] 5161 gacggggatg gtttgaggaa acacttttaa agaaaaaagg aagacattga aaggttttag

[1602] 5221 tttcttccct atctgcatgt cctctcatat agaaagccca gaattagggg ctagaactcc

[1603] 5281 aggagagggt ctccccgact catctcttgc tgacggtcac caggatgcag aaatagggag

[1604] 5341 atggttagtg ggggccaaag atgccccctc ccaggccttc gtggttccct cctccgcccc

[1605] 5401 ctgcaatctt tggagagtc agtgcctcac tccagcagtg agtgcctact gtatgcaggt

[1606] 5461 agtcagccag gcaaagagag actaacggtc tcatggggga accctcttgc gggaggccgg

[1607] 5521 gtagctggag cgaagcgttc cggctgccct tgctgctggg tggagtggag agggagactt

[1608] 5581 ctttttgttg gttttaattt aaaaacacaa aggcctaaag aaatacgtat cttataattt

[1609] 5641 ttttaatttt tgagacgttc atttaatgaa ttgtgcacga atgaattcta tatatataaa

[1610] 5701 atatacatat atagctctat atttggggag gggcactgtc tcttttttct ctcattttta

[1611] 5761 aaatgaagtg ttgttgcctt tgtatgtggt tcaacatcc agctcccagc tggctaaact

[1612] 5821 ttgcctccag tggtcaaaga tgggaaaga gtggggttgg caggagatgg aaaacggagg

[1613] 5881 tgccgcccca gcatgggggg caggtccccc agtccaccct gcccctcccc ctgtggagaa

[1614] 5941 gacgcttagt tggggtgtg ggtttgggct ccattctgga ttcggcggtt ccgggggagg

[1615] 6001 ggtgggtctg tgccgattac tctgtctttgt acgtttgttc tgctgctctt caatattgta

[1616] 6061 tcaacgccag gaaagggggg tgaaaagcct cttttacccc ccaaataaat tgtcacattc

[1617] 6121 cgaagctgag gcctagcccc taggttgggg tgtgtctgtg tcttc (서열 번호 113)

[1618] CBX7(등록 번호 NM_175709):

[1619] 1 ccagccccag catcgcgcg cgcagccgg gccccgcagc tccgcccg gcccggcg

[1620] 61 gcccgggcc cgctcgcccg ccgccccgca tggagctgtc agccatcggc gagcaggtgt

[1621] 121 tcgccgtgga gagcatccgg aagaagcgcg tgcggaaggg taaagtcgag tatctggtga

[1622] 181 agtggaaagg atggccccca aagtacagca cgtgggagcc agaagagcac atcttggacc

[1623] 241 cccgcctcgt catggcctac gaggagaagg aggagagaga ccgagcatcg gggtatagga

[1624] 301 agagaggtcc gaaacccaag cggcttctgc tgcagcggct gtacagcatg gacctgcgga

[1625] 361 gctcccacaa ggccaagggc aaggagaagc tctgcttctc cctgacgtgc ccactcggca

[1626] 421 gcgggagccc tgagggggtg gtcaaggcgg gggcacctga gctggtggac aagggcccct

[1627] 481 tggtgcccac cctgcccttc ccgctccgca agccccgaaa ggcccacaag tacctgcggc

[1628] 541 tctcgcgcaa gaagttcccg ccccgcgggc ccaacctgga gagccacagc catcgacggg

[1629] 601 agctcttcct gcaggagcca ccggccccag acgtcctgca ggcggctggc gagtgggagc

[1630] 661 ctgctgcgca gccccctgaa gaggaggcag atgccgacct ggccgagggg ccccctccct

[1631] 721 ggacacctgc gctcccctca agtgaggtga ccgtgaccga catcaccgcc aactccatca

[1632] 781 ccgtcacctt ccgcgaggcc caggcagctg agggcttctt ccgagaccgc agtgggaagt

[1633] 841 tctgaatcac cgtttttact cttcttaaac tgttttcttt tgggcttggg gtgggacttc

[1634] 901 cagagatagg gatgggttgg gggcggggta attattttat ttaaaaaaat accgagcagc

[1635] 961 aaaaggggag aagatcccac tactctccca ccacctgccc tttctctgag ggacgtttac

[1636] 1021 cacgaggcct caggctgggg atggagagag ttgctctggg agttggggta ccacccccag

[1637] 1081 ggcaggatgg ggacaggatc acctgcccgg gacaccacca ttatcattct cctctagtga

[1638] 1141 cgcagcagct ggttctggga gttaaaggag cattggaagg cccaaaccct ctcccttgag

[1639] 1201 tggccacccc agcctggttg gctggttttc cccttttctc ttgtttcaat tgggtcttta

[1640] 1261 ccttgaactc tcctctctgg ctttgcggtg ggctgtggag gctggttttg accaaaagtg

[1641] 1321 agtggggcgg gaggaagggg caggaggaag ggttgaggtt acttggggcg agtcccttcc

[1642] 1381 ccttcagaga ggcttctatc cttcccaggg aggaggcgcc gctgagaccc ttctgctgag

[1643] 1441 agctctgccc tcccctcatc acctggcctg tgcagaaacg ctcatgcaca cctggctgca

[1644] 1501 caggtgtgca cgcattaccc ttcgcgtgta cgttcccatg tgccccgtga aagcatgtgt

[1645] 1561 ggctgcagac gtgtccacat gggccttgcg aacctgggtt agaaaccctg gccaggcgaa

[1646] 1621 cgtggggtga ttcacagcac aaaagacctc accaccacac ctgcactcac cccaccttgc

[1647] 1681 atgcaccttg ctacctgctt gcggctttca gtggagggca ggggtctggc acaggtgcga

[1648] 1741 tggcacccca tgctccaggc atacagatgt ggtttctcgg ctgcaccggg ccaggctgcg

[1649] 1801 ggtgtgcagg cgtctgctaa gttgtgtgat gtatcagcac aggctttgag acgtctggac

[1650] 1861 cctgtccttc ctcccgtgag gggttcttgt tctttctgac tcaggtgact tttcagccct

[1651] 1921 tccaattccc ctctttttct gccctcccct ccaactcagc caacccaggt gtgggcagtc

[1652] 1981 agggagggag ggagtgtccc accacgttct cagggcagcc cttgactcct aagccccttc

[1653] 2041 ctccttccat tctgcatccc ctccccatcc aacctaaatg ccacagctgg ggctgagctg

[1654] 2101 tattcctgtg gagggacctc tgccgtgcct ctctgaggtc aggctgtgct gtgtgatggg

[1655] 2161 caggctttgc cccagcccac ccctggcaag gtgcacttgt tttctggttt gtacaaggtg

[1656] 2221 tcctgggggc ccgtggcttc cctgccagtg aggagtgact tctccctctc ttccagtcct

[1657] 2281 gtaggggaga caaaaccaga ttggggggcc caaggggagc atggaaaagg ccggctcccc

[1658] 2341 tgtctttcct tggctgtcag agtcagggta acacacacca agagtggagt gcggccagca

[1659] 2401 agtttgagac ctgcccgccc tcctcgcagc tctgctctgt gtcctcagga agtcacagag

[1660] 2461 tctactgagg caaggagagg gtgattcttt ccccaaatcc cttcttccct ggttcccaaa 2521 ccaaagacag cctgcagccc tttctgcatg gggtgctctg ttgacaggct tcccagatcc

[1661] 2581 ctgagtctct ctttccttcc tcctcgatct ttagttgtcc acggtcaatt cagtgcttcc

[1662] 2641 attgggggac agtcccctcc gggatgacct gattcacctc cagcccaggg aatggaatct

[1663] 2701 agaggaatac gtggggtggg tctggacaag gagcggcagg aatcaccacc catctccagc

[1664] 2761 tgtggagccc tgtggagggg aaggggaagc ttggggttca gaggggactc ttccaggaga

[1665] 2821 ggggtgccca gcggaggtaa agatgataga gggttgtggg gggtctctag ttgaatgttt

[1666] 2881 tggcccatga ctttggaaca tggctggcag cttccagcag aagtcacgct ccccatcccc

[1667] 2941 caggggacat aggacctttt tcctgcttcc tggtcacttt caaagaacta tttgcgcaat

[1668] 3001 ctgtgggtct gtggattcac ggggctttct gtgtgggtgc tgcagttgct tttgtctgca

[1669] 3061 gcagcaggac acatctttcc tcttactcag ccctttatgg cccatgggga actccgtggc

[1670] 3121 tcagggagag ctgaactcca ggggtgtgac ctgggacggg tgggcctgag gtgcccagct

[1671] 3181 cagggcagcc aggtggctca tgggctgtag tgagccagct ccctggggga aaaggctgtg

[1672] 3241 ggccgttagg accatcctcc aggacaggtg acctctatga ggtcacctac ggctgtggcc

[1673] 3301 gtgcaggcct ccttccagcc cagagtggcc cagtagagca aggcagacag tgacctccac

[1674] 3361 ccccgcagcc ctcttaaaag gccagtactc ttgggggtgg ggggagggtt tagaaagcat

[1675] 3421 ttgcccatct gcctttcttt cccccagccc ccacccgctt tgaatgtaga gacccgtggg

[1676] 3481 cacttttcct tttgtggtgg ggggtgcgga ggaggtaccc ccacccctgg cacagccgcc

[1677] 3541 tggaatgcag gactgtcact gctgttcggg tgatgacctc gttgccaagc tcctcctgtc

[1678] 3601 cccttgttct gggggcaggc gctgtgcttc tgtgaggtgg tttagctttt gctttcgaag

[1679] 3661 tggccagctg cggccaccag gtctcagcac aagagcgctt cctttgcaca gaatgagctt

[1680] 3721 cgagctttgt tcagactaaa tgaatgtatc tgggaggggt cggggcacg agttgattcc

[1681] 3781 aagcacatgc ctttgctgag tgtgtgtgtg ctggagagt cagagtggat gtagacgcgc

[1682] 3841 gttttatttt tgtactgaca ttggtaagag actgtatagc atctatttat ttagatgatt

[1683] 3901 tatctggtaa atgaggcaaa aaaattatta aaaatacatt aaagatgatt taaaaaaaag

[1684] 3961 aaaa (Seoul number 114)

[1685] PHC1 (registered number NM_004426):

[1686] 1 cccgccgcgg aggccgagcg agcccccagc ccagcctggc gactggggac cccggcacat

[1687] 61 gaggtggacg cccccgggga agacttgggt gcacagccag gcgagaaggt cttgagtcag

[1688] 121 acagagcacc agccttgggg accctggacc actatcatgg agactgagag cgagcagaac

[1689] 181 tccaattcca ccaatgggag ttctagctca gggggcagct ctcggcccca gatagctcaa

[1690] 241 atgtcacttt atgaacgaca agcagtgcag gctctgcaag cactgcagcg gcagcccaat

[1691] 301 gcagctcagt atttccacca gttcatgctc cagcagcagc tcagtaatgc ccagctgcat

[1692] 361 agcctggctg ccgtccagca ggccacaatt gctgccagtc ggcaggccag ctccccaaac

[1693] 421 accagcacta cacagcagca gactaccacc acccaggcct cgatcaatct ggccaccaca

[1694] 481 tcggccgccc agctcatcag ccgatcccag agtgtgagct ctcccagtgc taccaccttg

[1695] 541 acccaatctg tgctactggg gaacaccacc tccccacccc tcaaccagtc tcaggcccag

[1696] 601 atgtatctac ggccacagct gggaaaccta ttgcaggtaa accgaaccct gggtcggaat

[1697] 661 gtgcctctag cctcccaact catcctgatg cctaatgggg cggtggctgc agtccagcag

[1698] 721 gaggtgccat ctgctcagtc tcctggagtt catgcagatg cagatcaggt tcagaacttg

[1699] 781 gcagtaagga atcaacaggc ctcagctcaa ggacctcaga tgcaaggctc cactcagaag

[1700] 841 gccattcctc caggagcctc ccctgtctct agcctctccc aggcctctag ccaggcccta

[1701] 901 gcggtggcac aggcttcctc tggggccaca aaccagtccc tcaaccttag tcaagctggt

[1702] 961 ggaggcagtg ggaatagcat cccagggtcc atgggtccag gtggaggtgg gcaggcacat

[1703] 1021 ggtggtttgg gtcagttgcc ttcctcagga atgggtggtg ggagctgtcc cagaaagggt

[1704] 1081 acaggagtgg tgcagccctt gcctgcagcc caaacagtga ctgtgagcca gggcagccag

[1705] 1141 acagaggcag aaagtgcagc agccaagaag gcagaagcag atgggagtgg ccagcagaat

[1706] 1201 gtgggcatga acctgacacg gacagccaca cctgcgccca gccagacact tattagctca

[1707] 1261 gccacctaca cacagatcca gccccattca ctgattcagc aacagcaaca gatccacctc

[1708] 1321 cagcagaaac aggtggtgat ccagcagcag attgccatcc accaccagca gcagttccag

[1709] 1381 caccggcagt cccagctcct tcacacagct acacacctcc agttggcgca gcagcagcag

[1710] 1441 cagcaacaac agcaacagca gcaacagcag cagccgcaag ccaccaccct cactgcccct

[1711] 1501 cagccaccac aggtcccacc tactcagcag gtcccacctt cccagtccca gcagcaagcc

[1712] 1561 caaaccctgg tcgttcagcc catgcttcag tcttcaccct tgtctcttcc acctgatgca

[1713] 1621 gcccctaagc caccaattcc catccaatcc aaaccacctg tagcacctat caagccgcct

[1714] 1681 cagttagggg ccgctaagat gtcagctgcc cagcaaccac caccccatat ccctgtgcaa

[1715] 1741 gttgtaggca ctcgacagcc aggtacagcc caggcacagg ctttggggtt ggcacagctg

[1716] 1801 gcagctgctg tacctacttc ccgggggatg ccaggtacag tgcagtctgg tcaggcccat

[1717] 1861 ttggcctcct cgccaccttc atcccaggct cctggtgcac tgcaggagtg ccctcccaca

[1718] 1921 ttggcccctg ggatgaccct tgctcctgtg caggggacag cacatgtggt aaagggtggg

[1719] 1981 gctaccacct cctcacctgt tgtagcccag gtccctgctg ccttctatat gcagtctgtg

[1720] 2041 cacttgccgg gtaaacccca gacattggct gtcaaacgca aggctgactc tgaggaggag

[1721] 2101 agagatgatg tctccacatt gggttcaatg cttcctgcca aggcatctcc agtagcagaa

[1722] 2161 agcccaaaag tcatggacga gaagagcagt cttggagaaa aagctgaatc agtggctaat

[1723] 2221 gtgaatgcta atactccaag cagtgaacta gtagccttga cccccgcccc ttcagtaccg

[1724] 2281 cctcctacac tagccatggt gtctagacaa atgggtgact caaaaccccc acaggccatc

[1725] 2341 gtgaagcccc agattctcac ccacatcatt gaaggctttg ttatccagga aggagcagaa

[1726] 2401 cctttcccgg tgggttgttc tcagttactg aaggagtctg agaagccact acagactggc

[1727] 2461 cttccgacag ggctgactga gaatcagtca ggtggccctt tgggagtgga cagcccatct

[1728] 2521 gctgagttag atagaaggc gaatctcctg aagtgcgagt actgtgggaa gtacgcccccc

[1729] 2581 gcagagcagt ttcgtggctc taagaggttc tgctccatga cttgcgctaa gaggtacaat

[1730] 2641 gtgagctgta gccatcagtt ccggctgaag aggaaaaaaa tgaaagagtt tcaagaagcc

[1731] 2701 aactatgctc gcgttcgcag gcgtggaccc cgccgcagct cctctgacat tgcccgtgcc

[1732] 2761 aagattcagg gcaagtgcca ccggggtcaa gaagactcta gccggggttc agataattcc

[1733] 2821 agttatgatg aagcactctc tccaacatct cctgggcctt tatcagtaag agctggggcat

[1734] 2881 ggagaacgtg acctggggaa tcccaataca gctccaccta caccggaatt acatggcatc

[1735] 2941 aaccctgtgt tcctgtccag taatcccagc cgttggagtg tagaggggt gtacgagttt

[1736] 3001 attgttctc tccaggctg ccagagatt gcagagat tcgctcaca ggagattgat

[1737] 3061 ggacaggccc ttttact taaagaaa catcttatga gtgccatgaa catcaagctg

[1738] 3121 gggcctgccc tcagatctg cgccagata atgctcca aggagaccta aggtggccct

[1739] 3181 cttgcacaaa ccagcctaag gcagacactc tccactgtcc aggttataac ctgtaccag

[1740] 3241 cagacttgc agggaaaa gagttgttcc atcatgtaa cttctgtag gggattactg

[1741] 3301 agacaggga gagagtgca agaattggtt gctggtgcta catggcggca gctttgacat

[1742] 3361 eyebrows eyebrows eyebrows eyebrows eyebrows eyebrows eyebrows

[1743] 3421 taatccaatc ttataaaag aggcagtcta gagaactagg actgctcagc cttatcctgg

[1744] 3481 agtggagcat tagcccagg tcttattct ccagaggag gatacatag tatggtagg

[1745] 3541 ggcaatg gggtggaatgt caggttgcct gcccaatggg agaggtaggg tttcttagc

[1746] 3601 ttgtgtgaca gaagtagcaa aatctggtcc tcccccctcc cagtgtagct gtggctcaga

[1747] 3661 gttttttctt tttgttgtca cttactccct tgtgattgaa ttttttctcc tgcatccatg

[1748] 3721 gcaggatccc cagccagtat agagacttgg ttggcatctt ctgctgcagg gactaaaagt

[1749] 3781 atttgactgg ggcacatgtg gctgttgtca ttctttctgc atccactgt tcccctccaa

[1750] 3841 tttatgttat tttctaccct gtttttcagt tccatctctg ctctgtccta tagctttata

[1751] 3901 aaaccagagt gtgtggggct gaggtcagga gtataagtac ctgccttagg cactattcct

[1752] 3961 tatataacaa aaatattaaa tattttttc ctcagtaaaa ggatgaaaat tggtttcagt

[1753] 4021 tgtcttactc tattccagtc tttgcccact ttcacacaaa tgacaaggcc aatatgttt

[1754] 4081 gtttgtttt taatcattaa gagtttttgt acaaaaggtg atggtttttt ttcttcattt

[1755] 4141 taaaacacca gggtgtgggg gagggatgca aacaaataac aaaaaagatg cttttgtaac

[1756] 4201 attattttcc ctgtttagaa agaaaaaaat cactccaata gtattgaaaa gtccaaagat

[1757] 4261 gaaatagttt cattttcttt tcctaaggct tataaaaggc cccctgcctg ttgattccat

[1758] 4321 ccctcttttg tgtccagtgg agccatgtta ctcttcagtg gcccaggggt tcactattaa

[1759] 4381 agaaagatca gtccaggttt ctgggcacat ggcctaaaca ggaagatgga agcatcagag

[1760] 4441 gattaaaaac ctttccccac agaaatgtgg gcaagaagac acttccctga gccagcagaa

[1761] 4501 gggacaggtg cagcagcatt ccacacccag cgcagaggac agcagagccc tcgatgtccc

[1762] 4561 acttctgctt ccgttccctt tctagaagat tgaaaaaaag gtcaaaacca catgcctgtg

[1763] 4621 gagaaagtgc gacatgttta gaaatactgg tagggaacca ggagtaagaa aagctttacc

[1764] 4681 agcttttact acaaatggat gaaagacatc aggatcccac caccgcaagg taaagtgact

[1765] 4741 tcccttttct ggaacccctg tggcacagga gtaccaattt tcctttccaa cgaactggat

[1766] 4801 ttctggatag gcatttggc tgtatggga cagataagac cacagtcctt agcccaatcc

[1767] 4861 cagctataca gtcaccccaa tttccacaaa tgatgtgatg gtaccgtata atcctgtaat

[1768] 4921 tgggaaattt cacatttttc ctgtcctaat ctcagaggtg ggagaagcaa gtctagaaca

[1769] 4981 tctccaggct cagactaaac gagagtactt ggactgcaac caagtaatca ctgcaaagta

[1770] 5041 gttccaagca gcaagaaata ccagattctc atggaggcta ctatagggta cagaataaca

[1771] 5101 acatgaaagc aatcaaccct gtataaataa tgtttcttgg catttttttt ttaattaaag

[1772] 5161 aaatccagtg tctcaaaaaa aaaaaaaaaa aaaaaaaaa aaaaaa (서열 번호 115)

[1773] PHC2 (등록 번호 NM_198040):

[1774] 1 catctgcctg cccttctgcc atccgagcgc cctgactgcg ccacactgca ggccatggag

[1775] 61 aatgagctgc cagtcccaca tacatctagc agtgcctgtg ccaccagcag taccagcggg

[1776] 121 gccagtagca gcagtggctg caacaacagc agcagtggtg gaagtggccg ccccaccggg

[1777] 181 ccccagattt ctgtgtacag tggtattcca gaccggcaga ccgtgcaggt gatccagcag

[1778] 241 gccctgcaca gacagcccag cacggccgct cagtacctgc agcagatgta cgccgcccag

[1779] 301 cagcagcacc tcatgctgca gaccgcggcg ctccagcagc agcacctcag cagcgcccag

[1780] 361 ctccagagcc tggcagccgt acagcaggca agcctggtat ccaatagaca aggaagcact

[1781] 421 tcaggcagca atgtgtctgc gcaggccccg gcccagtcat cttcgatcaa cctggcagcc

[1782] 481 tccccagcag cagcccagct cctcaaccgg gcccagagtg tgaactctgc agcagcctca

[1783] 541 ggcatcgctc agcaggctgt gctcttgggc aacacgtctt ccccagccct gactgcaagc

[1784] 601 caagcacaga tgtatctgag ggcacagatg ctcatcttca cgcccacggc caccgtcgct

[1785] 661 actgtgcagc ctgagctcgg cactggctcc cccgcccggc cccccacccc cgcccaggta

[1786] 721 cagaacttga ccctccgaac acagcagaca ccagcggcag cagcctcggg ccccaccccc

[1787] 781 actcagcctg tcctgcccag cttggccctg aaacccacgc cgggcggtag ccagcctctg

[1788] 841 cctaccccag cacagagcag aaatactgct caggcttccc ctgcaggtgc caagcctggc

[1789] 901 atagctgaca gtgtgatgga gccacacaag aaaggagatg gcaacagcag tgtgccaggg

[1790] 961 agcatggaag gccgggctgg gctcagccgg acggttcctg ctgtggctgc ccaccccctc

[1791] 1021 attgcaccag cctatgctca gctgcagcca caccagctcc tcccacagcc atcctcaaag

[1792] 1081 cacctgcagc cccaatttgt gatccagcag cagccacagc cacaacagca gcagccgccg

[1793] 1141 ccccagcagt cacggcctgt gctccaagct gagccccacc cccagctcgc ctcagtctct

[1794] 1201 ccaagcgtgg ccctccagcc cagctcagag gcccatgcca tgccactagg cccggttaca

[1795] 1261 cccgccctgc cactccagtg tcccactgcc aacctgcaca agcctggcgg cagtcagcag

[1796] 1321 tgtcaccctc ccacacctga tactgggcct cagaatggac atcccgaggg cgtgccccac

[1797] 1381 acccctcaac gcaggttcca gcacacttca gctgtcatct tacaactgca gcctgcttca

[1798] 1441 ccaccccagc agtgtgtccc tgatgactgg aaagaagtgg caccagggga gaaaagtgtg

[1799] 1501 cctgagacgc ggtctggccc atcaccacat cagcaggcta ttgtcactgc catgcctggt

[1800] 1561 ggcctgcctg tacccacgag ccctaacatc cagccgtccc cagctcacga gacagggcag

[1801] 1621 ggcattgttc atgcactgac cgacctcagc agccccggca tgacctcagg gaacggaaac

[1802] 1681 tctgcctcca gcatcgccgg cactgccccc cagaatggtg agaataaacc accacaggcc

[1803] 1741 attgtgaaac cccaaatcct gacgcatgtt atcgaagggt ttgtgatcca ggagggggcg

[1804] 1801 gagcctttcc cggtgggacg ctcgtccctg ctggtgggga atctcaagaa gaagtatgca

[1805] 1861 caggggttcc tgcctgagaa acttccacag caggatcaca ccaccaccac tgactcggag

[1806] 1921 atggaggagc cctatctgca agaatccaaa gaggagggtg ctcccctcaa actcaagtgt

[1807] 1981 gagctctgtg gccgggtgga ctttgcctat aagttcaagc gttccaagcg cttctgttcc

[1808] 2041 atggcttgtg caaagaggta caacgtggga tgcaccaaac gggtgggact tttccactca

[1809] 2101 gaccggagca agctgcagaa ggcaggagct gcgacccaca accgccgtcg ggccagcaaa

[1810] 2161 gccagtctgc caccacttac caaggatacc aagaagcagc caacaggcac tgtgcccctt

[1811] 2221 tcggttactg ctgctttgca gctaacacac agccaggaag actccagccg ttgctcagat

[1812] 2281 aactcaagct atgaggaacc cttgtcaccc atctcagcca gctcatctac ttcccgccgg

[1813] 2341 cgacaaggcc agcgggacct ggagctcccc gacatgcata tgcgggacct ggtgggcatg

[1814] 2401 ggacaccact tcctgccaag tgagcccacc aagtggaatg tagaagacgt ctacgaattc

[1815] 2461 atccgctctc tgccaggctg ccaggagata gcagaggaat tccgtgccca ggaaatcgac

[1816] 2521 gggcaagccc tgctgctgct caaggaggac cacctgatga gcgccatgaa catcaagctg

[1817] 2581 gggcccgccc tgaagatcta cgcccgcatc agcatgctca aggactccta gggctggtgg

[1818] 2641 cagccaggat tctggcccag ggcgcctcct cccgactgag cagagccaga cagacattcc

[1819] 2701 tgaggggccc agaaatgggg ccggttggag ggcaggggct ctccctaggg gcatagctgg

[1820] 2761 tgaggaggtc tgggcacctc ctccatggct ctcaggggcc ttcatttct gtgggagggg

[1821] 2821 cagagaggta ggtggcacag aagatggggc tttatgcttg taaatattga tagcactggc

[1822] 2881 ttcctccaaa gtcccaatac tctagccccg ctctcttccc ctctttctgt cccccatttt

[1823] 2941 ccagggggta tatggtcagg gctccccaac ctgagttggg ttacttcaag ggcagccagc

[1824] 3001 aggcctggat ggaggcctag aaagcccttg ccttccttcc tcccacttct ttctccaggc

[1825] 3061 ctggttaact cttccgttgt cagcttctcc cccttcagcc tgtttctgca gcagccaggg

[1826] 3121 ttctcccccc tacaccctct gcaggtggag agagagaagc tgggcccagc cgggccgtgc

[1827] 3181 ctgctggcac agacgcctta acgctgtgtg tatgactgtg tgactgtgtg ggagcctgga

[1828] 3241 ctgacagata ggccaagggc tactctctgg catctccagg tgttttgtag caaacagcca

[1829] 3301 cttagtgctt tgtcctggac tccactcagc ctcaggatgg ggaatagcca agaatggcag

[1830] 3361 cctcagcgca gaggcaaggt cagaaagaga cggcgcttca gagtttcctt tccagacacc

[1831] 3421 cctccccgca ctgtgaagtt cccctgaccg ccctcctggt tcacaaagag cattaagaa

[1832] 3481 gctgcggtgg tctgagcaac atagcccaaa gggctgagcc tcctggcctg cctgcccgcc

[1833] 3541 caccctggga gtcccagtgg tgaggctcag agaactgcta aggggaaga acagctggag

[1834] 3601 tttctgttga tgtgaagaag gcagctcttg gcctcccact cccacacttc tttgcctata

[1835] 3661 aatcttccta gcagcaattt gagctacctg aggaggaggc agggcagaaa gggcgagggc

[1836] 3721 ctgcctctga cctgccgtgt cctttgcagg aaggaggtag gcaccttct gagcttattc

[1837] 3781 tattccccac ccacaccccc aggcagggtt ggaaatgaag gactttttta acctttgttt

[1838] 3841 tgttttttaa aaataaatct gtaaaatctg tct (서열 번호 116)

[1839] PHC3(등록 번호 NM_024947):

[1840] 1 atgcgcagcc catgttagtg atggaggaga gaagatggcg gaagcggaat ttaaggacca

[1841] 61 tagtacagct atggatactg aaccaaaccc gggaacatct tctgtgtcaa caacaaccag

[1842] 121 cagtaccacc accaccacca tcaccacttc ctcctctcga atgcagcagc cacagatctc

[1843] 181 tgtctacagt ggttcagacc gacatgctgt acaggtaatt caacaggcat tgcatcggcc

[1844] 241 ccccagctca gctgctcagt accttcagca aatgtatgca gcccaacaac agcacttgat

[1845] 301 gctgcatact gcagctcttc agcagcagca tttaagcagc tcccagcttc agagccttgc

[1846] 361 tgctgttcag gcaagtttgt ccagtggaag accatctaca tctcccacag gaagtgtcac

[1847] 421 acagcagtca agtatgtccc aaacgtctat caacctctcc acttctccta cacctgcaca

[1848] 481 gttaatagc cgttcccagg cttccagttc taccagcggc agtattaccc aacagactat

[1849] 541 gttactaggg agtactccc ctacctaac ggcaagccaa gctcaatgt atctccgagc

[1850] 601 tcaatgctg atttcacac ccgctaccac tgtggctgct gtacagctg acatcctgt

[1851] 661 tgtctcgtcg tcatcgtcat cttcctgtca gtctgcagct actcaggttc agaatttaac

[1852] 721 attackcagc cagaagttgg gtgtattatc tagctcacag aatggtccac caaaagcac

[1853] 781 tagtcaact cagtcattga caatttgtca taacaaaca acagtgacca gttctaaaat

[1854] 841 cagcaacga gatccttctc cagaaagta tagaagga gagagccca gcctggaatc

[1855] 901 acgaagcaca gctgtcaccc ggacacaag tattcaccag ttatagcac cagctcata

[1856] 961 ttctccaatt cagcctcatt ctctaataaa acatcagcag attcccttc attcaccacc

[1857] 1021 ttccaagtt tcccatcatc agctgatatt aacagcag siacagcaa ttcagccaat

[1858] 1081 cacacttcag aattcaactc aagacccacc cccatcccag cactgtatac cactccagaa

[1859] 1141 ccatggcctt cctccagctc ccagtaatgc ccagtcacag cattgttcac cgattcagag

[1860] 1201 tcatccctct cctttaacag tgtctcctaa tcagtcacag tcagcacagc agtctgtagt

[1861] 1261 ggtgtctcct ccaccacctc attcaccaag tcagtctcct actataatta ttcatccaca

[1862] 1321 agcacttatt cagccacacc ctcttgtgtc atcagctctc cagccagggc caaatttgca

[1863] 1381 gcagtccact gctaatcagg tgcaagctac agcacagttg aatcttccat cccatcttcc

[1864] 1441 acttccagct tcccctgttg tacacattgg cccagttcag cagtctgcct tggtatcccc

[1865] 1501 aggccagcag attgtctctc catcacacca gcaatattca tccctgcagt cctctccaat

[1866] 1561 cccaattgca agtcctccac agatgtcgac atctcctcca gctcagattc caccactgcc

[1867] 1621 cttgcagtct atgcagtctt tacaagtgca gcctgaaatt ctgtcccagg gccaggtttt

[1868] 1681 ggtgcagaat gctttggtgt cagaagagga acttccagct gcagaagctt tggtccagtt

[1869] 1741 gccatttcag actcttcctc ctccacagac tgttgcggta aacctacaag tgcaaccacc

[1870] 1801 agcacctgtt gatccaccag tggtttatca ggtagaagat gtgtgtgaag aagaaatgcc

[1871] 1861 agaagagtca gatgaatgtg tccggatgga tagaacccca ccaccaccca ctttgtctcc

[1872] 1921 agcagctata acagtgggga gaggagaaga tttgacttct gaacatcctt tgttagagca

[1873] 1981 agtggaatta cctgctgtgg catcagtcag tgcttcagta attaaatctc catcagatcc

[1874] 2041 ctcacatgtt tctgttccac cacctccatt gttacttcca gctgccacca caagggagtaa

[1875] 2101 cagtacatct atgcacagta gcattcccag tatagagaac aaacctccac aggctattgt

[1876] 2161 taaaccacag atcctaaccc atgttattga aggctttgtg attcaggagg gattggagcc

[1877] 2221 atttcctgtg agtcgttcct ctttgctaat agaacagcct gtgaaaaaac ggcctctttt

[1878] 2281 ggataatcag gtgataaatt cagtgtgtgt tcagccagag ctacagaata atacaaaaca

[1879] 2341 tgcggataat tcatctgaca cagagatgga agacatgatt gctgaagaga cattagaaga

[1880] 2401 aatggacagt gagttgctca agtgtgaatt ctgtgggaaa atgggatatg ctaatgaatt

[1881] 2461 tttgcggtca aaacgattct gcactatgtc atgtgccaaa aggtacaatg ttagctgttc

[1882] 2521 taaaaaattt gcacttagtc gttggaatcg taagcctgat aatcaaagtc ttgggcatcg

[1883] 2581 tggccgtcgt ccaagtggcc ctgatggggc agcgagagaa catatcctta ggcagcttcc

[1884] 2641 aattacttat ccatctgcag aagaagactt ggcttctcat gaagattctg tgccatctgc

[1885] 2701 tatgacaact cgtctgcgca ggcagagcga gcgggaaaga gaacgtgagc ttcgggatgt

[1886] 2761 gagaattcgg aaaatgcctg agaacagtga cttgctacca gttgcacaaa cagagccatc

[1887] 2821 tatatggaca gttgatgatg tctgggcctt catccattct ttgcctggct gccaggatat

[1888] 2881 cgcagatgaa ttcagagcac aggagattga tggacaggcc cttctcttgc tgaaagaga

[1889] 2941 ccatctcatg agtgcaatga atatcaagct agcccagcc ctgagatct gtgcacgcat

[1890] 3001 caactctctg aaggaatctt aacaggaaca tgaagccttg aaaacagc agttttactt

[1891] 3061 ttctcacaa aacttgtaag gtaaaggcct aacttggtct agaatgac acttattgtg

[1892] 3121 gtggatagcc aagcacattg ggatctccac atcaatct gatattct ctacaggtat

[1893] 3181 aaattcat catgcatttt cataattt aaacattggt aaatttatt ttacaggtta

[1894] 3241 catgaaacat tgaagactt gttacagagg gccatgatat tttcaaga aatgtgttat

[1895] 3301 actagataat ttttaaag gtgatgttta tcattaatat aaagaatcct tttaaagta

[1896] 3361 atttaatgat tttacatttct cctctttga ttcatttc ttatacattt ttctacct

[1897] 3421 attagtttc taaagttgt catgagaggt atattatgga atatttagt catccagtga

[1898] 3481 cagaatcgta tgaaatcagt gtacatttta aaaaacatgt cttttagaca tatgctttat

[1899] 3541 ctataaaaaa ggaattgtgt tctagtatga acaatactga tctggaagtg agaagagtta

[1900] 3601 gttcttattc caaacttgac caagaatttg gtttgactga gaacgttttc ctctcagttt

[1901] 3661 ttgtacattt atttagagca gtggttctca gtggaggtca gttttgatcg ccaggggaca

[1902] 3721 tctggcaatg ttgagacatt ttggttgtca cagcttgggg gtgggttcag gggaggggttg

[1903] 3781 ctactggtgt ctagtagtta gaagccagag atgtttctaa acatcttata atgcacagga

[1904] 3841 cagcacccct ccactgtaaa gaattattgg ttcaaaaata tcggtactgc caaggttgag

[1905] 3901 aaactctgat atagaaggag tgataaatat tgttttcacc caaaggaata cttttaaagg

[1906] 3961 atgaagctta ctaaacatat atgatggaag tattattcag ataacattaa tattctgctg

[1907] 4021 aataatttt tctagtttaa tcatactaga aaaagaaaaa aaatctacaa attgtcctat

[1908] 4081 aaaataagga caaacatgca aataatttaa ctctcagaaa gtactaattc attctgatta

[1909] 4141 tctttcatac ctctgtgctc ctctgcactg acgaagacat aatatgatta tacctatgaa

[1910] 4201 ctagtgcaca gccttttctg gcaagaaaat agtttgtagc agatacgtgg ttgctctttg

[1911] 4261 gattttttc tattgttgaa catgctggga ctagctagaa tgcacattcc tacttccttt

[1912] 4321 accaaacgtt tgcatgcttc ctgcaaagca cttaccaagt gatttctctt gaaccatcgg

[1913] 4381 atataatttt gtatgtacat gtttgaggaa aaaaatgtaa agcaaaacct tttactgaac

[1914] 4441 agtgttctat agaattatga cactaaaaca aaattgtttg tggaagccct gaaagcttta

[1915] 4501 tagtcctgga catcaaaaat tttatttgag atgatgaatg ttttgttttc atctttttct

[1916] 4561 atattaccac aattgagata ttttagtaat tgaaggaaca tacacagata tttggcagaa

[1917] 4621 gtcgagtaag gaggggaaa aaagagtccg tgagtttcag tcattttcac tgctctttc

[1918] 4681 aaaagattg tgttgagctg gtagaagact aagatgtca ctgagacat cacagatact

[1919] 4741 atatttatct tttggttg tgtacattag agaatgttga tttttat acaaaaatac

[1920] 4801 agcggtaat ttttaatc tttagatgcc tcttgtttga atgtatgctt tgtggaattc

[1921] 4861 ttgtgtagt aatgttttaa aaaagatgt ttactgatag ttacatgtag gattagaata

[1922] 4921 tgtataa tataaggctc atgttccaga cctacgatag cttgtagtct atgttacgta

[1923] 4981 tttcttta tcacatttt aatcattgga ttaagtatc aaggaaagct aggtactcta

[1924] 5041 taatgagttt tcatttatta gcagttaatc atcatgacag aattgtcata tgcttgactt

[1925] 5101 ttcccttc ttggaatttc agaacacaa tacaggcta gcattagtaa gagatggccc

[1926] 5161 acagtatgag agagagaggt gcaacggaaa atctcgcctg gattaaac tttcataga

[1927] 5221 ttatccacgg ttaatacaaa atttattata tgggataga ctgctccagc ataatgatt

[1928] 5281 acatcctata actgtattac ctatggcctt taaggtatca attttgaact gtgttgtagg

[1929] 5341 ctctcctttt atttgttctc tttcctaata gcagccattc tgtacttatt gaaagcccct

[1930] 5401 gtgcctactg ctgtcttaag tattcaggag gggcttacaa gaggttttc tattggagaa

[1931] 5461 taccgtata tcttaaatct agtccagatc tctgttgtcc ccactcaaaa catacacaaa

[1932] 5521 atatgcactt gcttttttca agtgagtttt tatttaaaaa tggcttgttt gctatcacat

[1933] 5581 tggtgcagct gtttctttca agatgagtta atcatcttaa tttcaaagct tcagctatat

[1934] 5641 father of the father of the actgagcatc cacctctctc ctgagcttta aagcagagtt

[1935] 5701 tcagtatgat ataggtgggg agagtaatt gttttcatat cctttcatac tactactaat

[1936] 5761 agttttagga ttttgactgg ggagagataa tgacaaacag aaagggaaca tggaggttct

[1937] 5821 tcctactttt gctacctaag tttgcatttt ctgacttcct tgcagtgttg cactctttgt

[1938] 5881 cccattggga taaaaagcat aagtttgaaa ttttgcttta agccttgtgt tcctggggaa

[1939] 5941 gttaaacaac taagagagct gatttgtaaa aattattttt tatatgacat taatattcat

[1940] 6001 caagccttgt gtaggcatgt gtaagacaca gctatgcagc tttgagtagt caatatagta

[1941] 6061 tgagatagag tgttgtccca aatcctcctg tcacttttta agtagnotata tatttccctg

[1942] 6121 atggtcctgt tactttgctg ttgaatgctc taaacagaac tttttaaaag gtgtgtttta

[1943] 6181 agagcagtca cctaggagta gacaaggtgg aatgggagga gagaatggt aatgcaaaag

[1944] 6241 cttgagcatg ggaagagtca gaggaggagg ccatcatcct tgttagctta gcctacttca

[1945] 6301 acactgagca catttctgca cttttgaagt gaaattcatg ttttacttag aagaaataat

[1946] 6361 tttctttcat tagggatccc agttgatttt tgtttcctgg tgtatcaaaa tacttagaac

[1947] 6421 tatgaaacaa gtattattgt gatcatgcct ttgaataatt tttgacgtag cttatcttca

[1948] 6481 tgtatcagt aaaattat atgagacat ctattcaca atacaagtct tattgaat

[1949] 6541 tgaaatgtgt tatagtgccc tgtctcccac tgactgttc agttaaatgt cttaaagtac

[1950] 6601 attatgtaca tcttcaggct ttgtacca caatgcaca agtagtag ggaggcaata

[1951] 6661 tagtcttagg ctatatgcct atattaagtg tgtataaaca atttttgaaa gatacacta

[1952] 6721 ttatagatgt atgtgagtga tgctgacctg acagccatat ccagtggatg aaactgactg

[1953] 6781 gacacactgt taaaatgttt taagatgta tttcagcca gaacagcctg gttatagtttt

[1954] 6841 gtggtttca ccttggtgga tgcaggac acatgcagcc tactggcatt gagcattagc

[1955] 6901 taatggcatg aaagggcctc atctcactac ctctctagg ccttagctc caaaaacc

[1956] 6961 atgaaactt ctttcttgga gagatctttg tctcagaatc cttagagagg atttcgtatg

[1957] 7021 ggggtact ttaggaaggg ggcagctgg ggcaggactt tctgatacct gggagtcatg

[1958] 7081 ttccagagca accttgggc agtggaact ggccatcta tgcaaatga ttgctcaatc

[1959] 7141 tctatcttgt gtactacata tgtactagc tgggccta ggaaggtttt ctagggggaa

[1960] 7201 ggatagggaa gtagaggagg agacaagtag gaggashaaa gcattctga cccagagga

[1961] 7261 Taggagat Taggataga Tatggctttc Atccatagtt Caaataatg Cgttttgtta

[1962] 7321 gatgccagtt atagcagtaa ataggttata gttttatat gtcagattt acctgtaatc

[1963] 7381 agactcattc ttcactc tatacccact gtctccatgc ttgggagcat ggatattaat

[1964] 7441 agttccagtg atgtagaagt tagtgattt tgatttctga aaaggtgag aaccttttat

[1965] 7501 tacagttgga gatatttgt caaaattca aaggttgttg taattgagtt gccagaatta

[1966] 7561 cagagttcc atttcagat atcacagttg atcacctct gtagattgtt ataagagag

[1967] 7621 gcattttaag atagtatttt atttgctagg ttgtgtctca gtctaagaat tgggaaaga

[1968] 7681 agagctag gtttctcttt cctagtctgg atttcagtaa acacaagcct acctctgctt

[1969] 7741 ctttggttca cagcagtgtg gatcatgaaa tgaactgttt acccacattc atcaatattg

[1970] 7801 gtattttaca aatctacttg gagcatttaa tttcatctca aagattgtga tccactttag

[1971] 7861 attachment attachment attachment cttactaaaa tttcaacttg

[1972] 7921 ttagctgta tatcttaaaa gaattatttt ggggctgggc atggtggctc acacctgtaa

[1973] 7981 tcccagcact ttgggaggct gaggtgggta gatcacctga ggtcaggagt tcgagaccag

[1974] 8041 cctgaccaat atggtgaaac cctatctcta ctaaaaacac aaaaattagc tgggtgtggt

[1975] 8101 ggcatgcacc tgtaattcca gctacttggg aggctgagac aggagaattg cttgaaccca

[1976] 8161 ggtggtggag gttgcagtga gccaagatca cacccctgca ctccagcctg ggtgacagag

[1977] 8221 cgagactcca tctcaaaaaa aacaaacaaa aaattatttg cgagatacg tcctcttttta

[1978] 8281 ttagaagttc ataaaatgta tcatatagtt ttgttcacag tagttatata agctttcttc

[1979] 8341 aaataaattt aaaattagat taccttcttt ggaaaaagaa tttcctaaat ttttaagaat

[1980] 8401 tttcaaagtt ttacatatta gtttttagaa cctaatccgt tttaaaattg tactatgaga

[1981] 8461 aagcttttt ttgaaagttg taaagcatta atacaaataa tacaaatata attattacca

[1982] 8521 tcacattcca gagaatatgg cttttctaa actttcaatt tagaaaacat acattaaggg

[1983] 8581 agaatctctg ccctcctttt cagctctgaa gatcagcttt tctactcaga cacatgcaca

[1984] 8641 caccccttcc aagtgtcatg tttatgggaa catttgggaa atgttttcca gatgttttat

[1985] 8701 ttttccctt tatagtttg ttgacattta atttactta aagatgacaa ttttaatcgg

[1986] 8761 aaatgttaga ggtacaacat agtgaggttc tagctagctt tatacttttg aaaaatattt

[1987] 8821 ttgtttctac tgctttttac aagtactagt cctctcagtg atactggtgg tgttcagtat

[1988] 8881 gaatccatag aaagaaaaca aaatttgttg tttaaaaaaa gcagagtaat gaatgaattt

[1989] 8941 cagttttgaa aacaacataa tttgaaaaca ctgttatact aacatggcaa ggtgttaatt

[1990] 9001

[1991] 9061 catcttaagg attgatagtc accatcactt attggcttaa aagttatatt tcatggataa

[1992] 9121 ttatcagtgt taaatccaag ctttgtggag ctttaagtga tggtggtgaa aaagttggtg

[1993] 9181 tttatgagag agtggtgggg tgtctagtca ttagtgaagt taaacatcaa cctgttttag

[1994] 9241 aaagaatttt ttaagtcttgc ctaaaaa ccagaagtgt ctagtgttta aatctttatt

[1995] 9301 tagaatgctt ctcttaaaag tattttttgt tttgggtagt attaataat footaataa

[1996] 9361 tctatttcag tagtaaata tgaattaaga tgatgatgaa tgaggattaa cacactggtc

[1997] 9421 tggagactgg ggttttatt cagtgggtta gctgtgtgtg acatgttggg caattactca

[1998] 9481 gctgttttaa cagcttccag atatgcagta tggtgctgt actactcaa agttgattt

[1999] 9541 gtttaattc atctttaagg tacctcccag ctctaaact atgatctag gctgtgtaat

[2000] 9601 ggggttattc ctactttatt ctctttcctt ttttaagggt tcattttata cttaataagc

[2001] 9661 atccattct tgggtcacct acagtcttg ttctcctag gattaaata gaaaattcat

[2002] 9721 acatacaag caatgatga cattttccta atgctcctt attggttaac cactgaat

[2003] 9781 atgacacat atgaatattg tcattcatgt acttaaattc atttagcaaa ctatttgaac

[2004] 9841 acttacatgt gcagtgtttg gtgaacatga catgaggaac tagtagtag taaaatctc

[2005] 9901 cccccaaat tcattgtgc tataataat atgacaata tcattactac tatatatact

[2006] 9961 Gagaggat cttaataac ttggactgg gagggaat ttgtatacat tggtaagg

[2007] 10021 gttaggctag atgacatcta aggggtctga gtgaatcata tcatatttt tataacacat

[2008] 10081 ttcacatact aaacatcagt tggccccata cctgattaag ttacaaaatt taggagactt

[2009] 10141 aacattaagg acttacaggt tgagacagcc cgtatttcac aacattattt tgacacttga

[2010] 10201 ctctattcca gagttgttgc tatacaaggc atgtggcaga acaaaaaaaa agctggtgtt

[2011] 10261 gatataagag ctttttaccc agtattgaca gtgagcaact ttctttcttt tttttttttt

[2012] 10321 ttcttttttt tttttttgag atgggttcgc tctgttgccc aggctggtgt gcagtggtgc

[2013] 10381 gatctcagct cactgcaacc tccacctccc gggttgaagc gattgtcttg cctcagcctt

[2014] 10441 ccaagtagct ggaattacag gtgcccgccg ccacacctgg ctaatttttg tatttttagt

[2015] 10501 agagacgggg cttcaccatg ttggccaggc tagtctcgaa ctcttgacct caagtgatcc

[2016] 10561 acctgccttg gcctccctaa gtgctgggat tacaggcatg agccaccaca cctgtccgac

[2017] 10621 agtgtagcaa ctttctaaaa ctgaaaaatc tcaaaggaga tcattggaac tgacttgttc

[2018] 10681 atttattttt tgttttaaa ttaagaaaga ttacacaaaa taaggtttac tgtactttaa

[2019] 10741 gctattacaa atatccaact tttaaagata tgtaagaatc agtaatattc tagaaagcac

[2020] 10801 atatatagta aaagggcatc ctttaaatgt agaacgggta aacatgaaac agttccatgc

[2021] 10861 ttgaattgtt aagtatctag ggggtaaaca ttgaatggga gaatcattta ttgggttaag

[2022] 10921 gtcccttcct tgtcattctg ggatctgtga atcacattgt aattcctgtt gacaaagctt

[2023] 10981 tacttgttaa catcagttga tactgacatt ctccataaag atatagaatg aaaatatcta

[2024] 11041 ttaaaaatag tttatcattg ttttagcttt tttgttttgt ttgttttgag acagagtctc

[2025] 11101 actgtcaccc aggcttgagt gcagcggtgt gatcttggct caatgcaacc tccacctccc

[2026] 11161 aggttcaata gattctccca ccttggcctc ccaagtagct gggattactg gcatgcacca

[2027] 11221 ctatgcctgg ccagtttttt gtatttttag tagagatggg gtttcaccat gttggccagg

[2028] 11281 ctggactcga actcctgacc tcagtgatc cgcccacccc agccccca agtgccggga

[2029] 11341 ttataggcat gagccactgc gcctagcctg ttgcagctt ttaaagcagg aaatatcca

[2030] 11401 tataaactgt tgggttagaa tctatattag atctttca actaattgaa aacaggaga

[2031] 11461 ctatcatcta agtagccaga taatctgggt ttcaaagt tattccatgg tactggttta

[2032] 11521 aaaatactt ttcaagtgtt ttaattttta aagtgtact aattctcaa atatgttatg

[2033] 11581 ctgttaaaat atgtattcca taagtacttt ttgtatatgt attctttaat tttaaaagt

[2034] 11641 caacgaatg cgcaagatg atattattt ggatgtagac attackacta gattcccagt

[2035] 11701 cctctccttc aaagcttgg tctttgttt tcctataggg aaaaagtca aaataagttc

[2036] 11761 CAAAACtat cctcaagta gtattgtgct tgtagtaat gaaggttgga tggatgata

[2037] 11821 ctgacaatgg tggcaggcat ttcaagcctt ttaaattagt actttgtc gtctgctta

[2038] 11881 ttaaaatttt gttaattta gcaaagacca attgttgtga taaactgtg ttttttgt

[2039] 11941 gcttcaagca cacgttaacc aattttaa ttcccctttt gttccccc attgttctaa

[2040] 12001 ataggactt tcatattatt aaaacctcaa aagatgatcc acccaggattg aaaagatc

[2041] 12061 accaggga aagaaaacat ttttactt tacagaaac atgttagat tatatataga

[2042] 12121 tgtattcttt acattgata ttgtattaga gtcctcctta caaaatga atagttttt

[2043] 12181 agcactctta gcattagagt tcctagattg gtgttgatag ctacagtttt aaaatgtata

[2044] 12241 acctgaaaat gaagttaat tttgcattgt aagagcacat ttgatctg taaaaagtgt

[2045] 12301 cattattgtg tatttttta aaaagagaa agcacttca tattaagtag catgtgtag

[2046] 12361 aatttagatt ttcatatttg tgtgtctgt attcagtgaa gtaaattgag catttaaatg

[2047] 12421 ttgttgatg gcaacattaa ctattaaatt aaagcacctt atactgct gcttaacttg

[2048] 12481 cttgtaattg cacctttgtt acctgcacat tttcatatag aatattgttg taacattgct

[2049] 12541 tcatgtgggt ctggatggaa gattagtggg cctacaggat catttattta tattgttat

[2050] 12601 attacaataa tatattgtag atcagttgta agttcatttc tttacaaata aaagcctctt

[2051] 12661 ccatttgact ggaaaaaaaa aaaaaaa (서열 번호 117)

[2052] BMI1(등록 번호 NM_005180):

[2053] 1 acagcaacta tgaaataatc gtagtatgag aggcagagat cggggcgaga caatggggat

[2054] 61 gtgggcgcgg gagccccgtt ccggcttagc agcacctccc agccccgcag aataaaaccg

[2055] 121 atcgcgcccc ctccgcgc gcctccccc gagtgcggag cggggagg cggcggcggc

[2056] 181 cgaggaggag gaggaggagg ccccggagga ggaggcgttg gaggtcgagg cggaggcgga

[2057] 241 ggaggagg gccgaggcgc cggaggaggc cgaggcgccg gagcaggagg aggccggccg

[2058] 301 gaggcggcat gagacgagcg tggcggccgc ggctgctcgg ggccgcgctg gttgcccatt

[2059] 361 gajagcggcg ttgcagctc gcttcagat ggccgcttgg ctcgcattca tttctgctg

[2060] 421 aacgactttt aacttcatt gtctttccg cccgctcga tcgcctcgcg ccggctgctc

[2061] 481 tttccgggat ttttatca gcagaaatgc atcgacaac gagaatcaag atcactgagc

[2062] 541 taaatcccca cctgatgtgt gtgctttgtg gagggtactt cattgatgcc acaaccataa

[2063] 601 tagaatgtct acatccttc tgtaaaacgt gtattgttcg ttacctggag accagcaagt

[2064] 661 attgtcctat ttgtgatgtc caagttcaca agaccagacc actactgaat ataaggtcag

[2065] 721 aaaactct ccagatatt gtatacaaat tagttccagg gcttttcaa atgaatga

[2066] 781 agagagaag ggatttat gcagctcatc cttctgctga tgctgccaat ggctctaatg

[2067] 841 agatagagg agaggttgca gatgagata agagattaat aactgatgat gagaataata

[2068] 901 gcttatccat tgaatttttt gaccagaca gattggatcg gaagtaac aagacaag

[2069] 961 agaatctaa ggaggaggtg atgataaaa gatacttacg atgcccagca gcaatgactg

[2070] 1021 tgatgcactt aagaaagtttt ctcagaagta aaatggacat acctaatact ttccattg

[2071] 1081 atgtcatgta tgaggaa cctttaaagg attattatac actaatggat attgcctaca

[2072] 1141 ttatacctg gagaaggaat ggtccacttc cattgaaata cagagttcga cctacttgta

[2073] 1201 aaagaatgaa gatcagtcac cagagagatg gactgacaa tgctgagaa ctggaagtg

[2074] 1261 actctgggag tgacaggcc aacagcccag caggaggtat tccctccacc tctcttgtt

[2075] 1321 tgcctagccc cagtactcca gtgcagctc ctcatccaca gtttcccc atttccagta

[2076] 1381 ctatgaatgg aaccaccac agccccagcg gtaccacca atctctttt gccaatagac

[2077] 1441 ctcgaaaatc atcagtaat gggtcatcag caactctc tggttgatac ctgagactgt

[2078] 1501 taggaaaaaattttaaac ccctgattta tatagatatc ttcatgccat tacagctttc

[2079] 1561 tagatgctaa tacatgtgac tatcgtccaa tttgctttct tttgtagtga cattaaattt

[2080] 1621 ggctataaaa gatggactac atgtgatact cctatggacg ttaattgaaa agaaagattg

[2081] 1681 ttgttataaa gaattggttt cttggaaagc aggcaagact ttttctctgt gttaggaaag

[2082] 1741 atgggaaatg gtttctgtaa ccattgtttg gatttggaag tactctgcag tggacataag

[2083] 1801 cattgggcca tagtttgtta atctcaacta acgcctacat tacattctcc ttgatcgttc

[2084] 1861 ttgttattac gctgttttgt gaacctgtag aaaacaagtg ctttttatct tgaaattcaa

[2085] 1921 ccaacggaaa gaatatgcat agaataatgc attctatgta gccatgtcac tgtgaataac

[2086] 1981 gatttcttgc atatttagcc attttgattc ctgtttgatt tatacttctc tgttgctacg

[2087] 2041 caaaaccgat caaagaaaag tgaacttcag ttttacaatc tgtatgccta aaagcgggta

[2088] 2101 ctaccgttta ttttactgac ttgtttaaat gattcgcttt tgtaaaatc agatggcatt

[2089] 2161 atgcttgttg tacaatgcca tattggtata tgacataaca ggaaacagta ttgtatgata

[2090] 2221 tatttataaa tgctataaag aaatattgtg tttcatgcat tcagaaatga ttgttaaaat

[2091] 2281 tctcccaact ggttcgacct ttgcagatac ccataaccta tgttgagcct tgcttaccag

[2092] 2341 caaagaatat tttaatgtg gatatctaat tctaaagtct gttccattag aagcaattgg

[2093] 2401 cacatctttc tatactttat atacttttct ccagtaatac atgtttactt taaagattgt

[2094] 2461 tgcagtgaag aaaaaccttt aactgagaaa tatggaaacc gtcttaattt tccattggct

[2095] 2521 atgatggaat taatattgta tttaaaaaat gcatattgat cactataatt ctaaaacaat

[2096] 2581 tttttaaata aaccagcagg ttgctaaag aaggcatttt atctaaagtt attttaatag

[2097] 2641 gtggtatagc agtaatttta aatttaagag ttgcttttac agttaacaat ggaatatgcc

[2098] 2701 ttctctgcta tgtctgaaaa tagaagctat ttattatgag cttctacagg tatttttaaa

[2099] 2761 tagagcaagc atgttgaatt taaaatatga ataaccccac ccaacaattt tcagtttatt

[2100] 2821 ttttgctttg gtcgaacttg gtgtgtgttc atcacccatc agttattgt gagggtgttt

[2101] 2881 attctatatg aatattgttt catgtttgta tgggaaatt gtagctaaac atttcattgt

[2102] 2941 ccccagtctg caaaagaagc acaattctat tgctttgtct tgcttatagt cattaaatca

[2103] 3001 ttacttttac atatattgct gttacttctg ctttctttaa aaatatagta aaggatgttt

[2104] 3061 tatgaagtca caagatacat atatttttat tttgacctaa atttgtacag tcccattgta

[2105] 3121 agtgttgttt ctaattatag atgtaaaatg aaatttcatt tgtaattgga aaaaatccaa

[2106] 3181 taaaaaggat attcatttag aaaatagcta agatctttaa taaaaatttg atatgaaaag

[2107] 3241 cacaatgtgc agaagttatg gaaaacctat agaggattac aacaggtaaa cgttaaagag

[2108] 3301 aatacattgc tgacttatag tgatgtggct aagaagtaca tgctttgttg taaaattgct

[2109] 3361 tgaaagccca ttgaaagatg tatctgttta tttacagtct ttgaagtaaa agttaccaat

[2110] 3421 gtttgccaat aaaaa (서열 번호 118)

[2111] PCGF2 (등록 번호 NM_007144):

[2112] 1 tctcccctcc cgccgcccgg gcgagcgaca cggctgcggc ccccctcccc tcccttccct

[2113] 61 ccctccctcc catccccccc tccccgagac ccaccggacc ccgaacccag atggccgaaa

[2114] 121 cgggctcccc gtcttaacga tttggcgtct ccctcgacca ccacctcttt gtgcagcagc

[2115] 181 ccccgggcag accctgttcc gagggcaacg ctccccagtc cccccacccc cgaccccgga

[2116] 241 atcatgcatc ggactacacg gatcaaaatc acagagctga acccccacct catgtgtgcc

[2117] 301 ctctgcgggg ggtacttcat cgacgccacc actatcgtgg agtgcctgca ttccttctgc

[2118] 361 aaaacctgca tcgtgcgcta cctggagacc aacaaatact gccccatgtg tgacgtgcag

[2119] 421 gtccataaaa cccggccgct gctgagcatc aggtctgaca aaacacttca agacattgtc

[2120] 481 tacaaattgg tccctgggct tttaaaagat gagatgaaac ggcggcggga tttctatgca

[2121] 541 gcgtaccccc tgacggaggt ccccaacggc tccaatgagg accgcgggga ggtcttggag

[2122] 601 caggagaagg gggctctgag tgatgatgag attgtcagcc tctccatcga attctacgaa

[2123] 661 ggtgccaggg accgggacga gaagaagggc cccctggaga atggggatgg ggacaaagag

[2124] 721 aaaacagggg tgcgcttcct gcgatgccca gcagccatga ccgtcatgca tcttgccaag

[2125] 781

[2126] 841 gagccactga aggaatacta caccctcatg gacatcgcct acatctaccc ctggcggcgg

[2127] 901 aacgggcctc tccccctcaa gtaccgtgtc cagccagcct gcaagcggct cacctagcc

[2128] 961 acggtgccca ccccctccga gggcaccaac accagcgggg cgtccgagtg tgagtcagtc

[2129] 1021 agcgacaagg ctcccagccc tgccaccctg ccagccacct cctcctccct gcccagccca

[2130] 1081 gccaccccat cccatggctc tcccagttcc catgggcctc cagccaccca ccctacctcc

[2131] 1141 cccactcccc cttcgacagc cagtggggcc accacagctg ccaacggggg tagcttgaac

[2132] 1201 tgcctgcaga caccatcctc caccagcagg gggcgcaaga tgactgtcaa cggcgctccc

[2133] 1261 gtgcccccct taacttgagg ccagggaccc tctcccttct tccagccaag cctctccact

[2134] 1321 ccttccactt tttctgggcc cttttttcca cctcttctac tttccccagc tcttcccacc

[2135] 1381 ttgggggtgg ggggcgggtt ttataaataa atatatatat atatgtacat aggaaaaacc

[2136] 1441 aaatatacat acttattttc tatggaccaa ccagattaat ttaaatgcca caggaaacaa

[2137] 1501 actttatgtg tgtgtgtatg tgtggaaaat ggtgttcatt ttttttgggg ggggtcttgt

[2138] 1561 gtaatttgct gtttttgggg gtgcctggag atgaactgga tgggccactg gagtctcaat

[2139] 1621 aaagctctgc accatcctcg ctgtttccca aggcaggtgg tgtgttgggg gccccttcag

[2140] 1681 acccaaagct ttaggcatga ttccaactgg ctgcatatag gagtcagtta gaatcgtttc

[2141] 1741 tttctctccc cgtttctctc cccatcttgg ctgctgtcct gcctctgacc agtggccgcc

[2142] 1801 ccccacgttg ttgaatgtcc agaaattgct aagaacagtg ccttttacaa atgcagttta

[2143] 1861 tccctggttc tgaggagcaa gtgcagggtg gaggtggcac ctgcatcacc tcctcctctt

[2144] 1921 gcagtggaaa ctttgtgcaa agaatagata gttctgcctc tttttttttt tttcctgtgt

[2145] 1981 gtgtggcctt tgcatcattt atcttgtgga aaagaagatt caggccctga gaggtctcag

[2146] 2041 ctcttggagg agggctaagg ctttagcatt gtgaagcgct gcacccccac caaccttacc

[2147] 2101 ctcaccgggg aaccctcact agcaggactg gtggtggagt ctcacctggg gcctagagtg

[2148] 2161 gaagtggggg tgggttaacc tcacacaagc acagatccca gactttgcca gaggcaaaca

[2149] 2221 gccttccaat tgcccctcca cccccagctg aggcccggtc acctggtcag gacagagcaa

[2150] 2281 ctgcatctaa aagcacaaga agacagaaac ctgtaagctc tgaccccacc cccacccctt

[2151] 2341 gagaggtcag cggaccacct ccttagggac agaccctggc aggtcgctgc ccaccgagat

[2152] 2401 ttcctcaagt gtgcatagat ctgagaggag tcgggagtcg agactcgaga ttccatcata

[2153] 2461 gcgtaggtgt gtggggttgg gagccccctg atgggcttgt ctgtgtttgc accttgtcct

[2154] 2521 gtgtctgagg tcctgtgact gtaccctcct ttgccctggg acatctgtat ctcttggctt

[2155] 2581 tgtaataaat gctgcatact ttctaaaaaa aaaaaaaaaa aa (서열 번호 119)

[2156] ZNF134 (등록 번호 NM_003435):

[2157] 1 cgaactgtga tggcggcggc cgcggtgatg ggcccggcgc agatcctctg tggttgttga

[2158] 61 attgtaacaa gagagagaac tctggctgcc tgagagggca tgactctagt cacagcagga

[2159] 121 ggggcttgga caggccctgg ttgttggcat gaagtgaagg atgaagagtc atcttctgaa

[2160] 181 cagagcattt ctatagcagt gtcacatgtt aatacttcca aggcaggttt gcccgcacag

[2161] 241 acggctctcc cttgtgacat atgtggcccc atcttgaaag atatttttgca cctggatgaa

[2162] 301 caccaggta cacaccatgg actgaaactt cacacatgtg gggcatgtgg gagacaattc

[2163] 361

[2164] 421 agggataaaa gtgaggcctc aattgtgaag aactgcacag ttagcaaaga acctcatccg

[2165] 481 tcagagaagc cctttacgtg tagggagag cagaaaaact tccaggctac tttgggtggc

[2166] 541 tgccaacaaa aggccatcca cattaagagg aagacacaca ggagcactga gagtggggat

[2167] 601 gcatttcatg gtgaacaaat gcattacaag tgcagtgaat gtgggaaagc tttcagccgc

[2168] 661 aaagacacac ttgtccagca ccagagaatt catagtggag agaagcctta tgagtgcagc

[2169] 721 gaatgtggga aagccttcag ccgcaaagct acacttgtcc agcatcagag aatccatact

[2170] 781

[2171] 841 actcagcaca agagaatcca cactggagaa atgccttata agtgcaatga atgtgggaaa

[2172] 901 tattttagcc atcactccaa tctaattgta caccagagag ttcacaatgg agcaaggcct

[2173] 961

[2174] 1021 agtattcaca ctggagaaaa tccttatgat tgcagtgatt gtgggaaatc ctttggccac

[2175] 1081

[2176] 1141 gaatgcggga aattctttag tcgaagttct gactatattg cacaccagag ggttcacact

[2177] 1201 ggtgaaaggc cttttgtgtg cattaaatgt gggaaagact ttatcagaac ctcccacctt

[2178] 1261

[2179] 1321 gcctacagct taagctccca cctcaatcgg caccagaaag ttcacactgc aggcaggctt

[2180] 1381

[2181] 1441 cattgacaca aaggagatac cttatggtgc caggtacgtg ggaaccttct agggatatgt

[2182] 1501 tgcactttct gacttgctca ggttttttgc cagagttatg tcactgtcaa tccatgtggc

[2183] 1561 cgaaaccatc ttaactctac cagctaagat accccagcat tggggaaggc agggttttgt

[2184] 1621 attgtccagt ccctggagaa aatcatgaaa tgcctgagtt cattgggggt cctcattccc

[2185] 1681 ttctgtatga caggtatagg tatggatatg acccattttt agccaagagg gtctgagctg

[2186] 1741 tatctgctgg tggcttatac aaaaagttta ctttcttcat ggatattctt ggtctcacat

[2187] 1801 acttgtaatc aagtttttcc agcctccaag tcacctggcc tgggaaagta cttgcctcat

[2188] 1861 gttgctctgg tttgtgataa taaaggcttt acagtttaag ccacatttaa tcttggggct

[2189] 1921 tcttcttatg gtctggggtg gattgaaaac aggctctgcc aaactgaaga cagcctttgt

[2190] 1981 gcggtgcctc caactttgcc tcaaatggga cagtgggttg agggagaaca gttcttagtc

[2191] 2041 cagttttgat gttaacttcc atagctgaca aagcttgtta agtaagaatt aagatcttgt

[2192] 2101 gtagacctga tttgtctgga ttttagagtt atttgagagc ccatatttca ccttgaggag

[2193] 2161 ggtgctgctg ctgtgacagc ctgcagtgtt ttgaaacagc atggattggg tgtcttgttt

[2194] 2221 gcagcatgtg tcccatgttc cccaacac (서열 번호 120)

[2195] RING1 (등록 번호 NM_002931):

[2196] 1 cagcgcccgg gccatggcgg cggcggtggc gggagctgct gtctgagcag cggttgcgga

[2197] 61 ccgagcgaac ttggcccagg agcccgggcc tagggagagg cgcggcggcg gcgggagcgc

[2198] 121 gaacggctgg agctggcctt cttcgccttc tcctcggctg tggagccctg gtggggggtc

[2199] 181 tgcgcccggt caccatgacg acgccggcga atgcccagaa tgccagcaaa acgtgggaac

[2200] 241 tgagtctgta tgagctgcac cggaccccgc aggaagccat aatggatggc acagagattg

[2201] 301 ctgtttcccc tcggtcactg cattcagaac tcatgtgccc tatctgcctg gacatgctga

[2202] 361 agaatacgat gaccaccaag gagtgcctcc acagattctg ctctgactgc attgtcacag

[2203] 421 ccctacggag cgggaacaag gagtgtccta cctgccgaaa gaagctggtg tccaagcgat

[2204] 481 ccctacggcc agaccccaac tttgatgccc tgatctctaa gatctatcct agccgggagg

[2205] 541 aatacgaggc ccatcaagac cgagtgctta tccgcctgag ccgcctgcac aaccagcagg

[2206] 601 cattgagctc cagcattgag gaggggctac gcatgcaggc catgcacagg gcccagcgtg

[2207] 661 tgaggcggcc gataccaggg tcagatcaga ccacaacgat gagtgggggg gaaggagagc

[2208] 721 ccggggaggg agaaggggat ggagaagatg tgagctcaga ctccgcccct gactctgccc

[2209] 781 caggccctgc tcccaagcga ccccgtggag ggggcgcagg ggggagcagt gtagggacag

[2210] 841 ggggaggcgg cactggtggg gtgggtgggg gtgccggttc ggaagactct ggtgaccggg

[2211] 901 gagggactct gggaggggga acgctgggcc ccccaagccc tcctggggcc cccagccccc

[2212] 961 cagagccagg tggagaaatt gagctcgtgt tccggcccca ccccctgctc gtggagaagg

[2213] 1021 gagaatactg ccagacgagg tatgtgaaga caactgggaa tgccacagtg gaccacctct

[2214] 1081 ccaagtactt ggccctgcgc attgccctcg agcggaggca acagcaggaa gcaggggagc

[2215] 1141 caggagggcc tggagggggc gcctctgaca ccggaggacc tgatgggtgt ggcggggagg

[2216] 1201 gtgggggtgc cggaggaggt gacggtcctg aggagcctgc tttgcccagc ctggagggcg

[2217] 1261 tcagtgaaaa gcagtacacc atctacatcg cacctggagg cggggcgttc acgacgttga

[2218] 1321 atggctcgct gaccctggag ctggtgaatg agaaattctg gaaggtgtcc cggccactgg

[2219] 1381 agctgtgcta tgctcccacc aaggatccaa agtgacccca ccaggggaca gccagaggaa

[2220] 1441 ggggaccatg gggtatccct gtgtcctggt ctatcacccc agcttctttg tcccccagta

[2221] 1501 cccccagccc agccagccaa taagaggaca caaatgagga cacgtggctt ttatacaaag

[2222] 1561 tatctatatg agattcttct atattgtaca gagtggggca aaacacgccc ccatctgctg

[2223] 1621 ccttttctat tgccctgcaa cgtcccatct atacgaggtg ttggagaagg tgaagaaccc

[2224] 1681 tcccattcac gcccgcctac caacaacaaa cgtgcttttt tcctctttga aacctgcaaa

[2225] 1741 aaaa (Sequence number 121)

[2226] RNF2 (Registration number NM_007212):

[2227] 1 gcgcctccgc ccctcgctcg ctcgctcctt cccgccctcc ccgcagcgcc ggccgagccg

[2228] 61 gcttcccctc agtctctcat gaatattgag cggcccctgt tgtatttccc gagctccatt

[2229] 121 gcggaagctg aggctcgcca tattgtgcgg cggcgccggc gtccgcggca gctgatacca

[2230] 181 gagtcttgct ccggccgcgg ccagcggagc cctgggctgg ggcaggagcc gcaatgtctc

[2231] 241 aggctgtgca gacaaacgga actcaaccat taagcaaaac atgggaactc agtttatatg

[2232] 301 agttacaacg aacacctcag gaggcaataa cagatggctt agaaattgtg gtttcacctc

[2233] 361 gagtctaca cagtgatta atgtgcccaa tttgtttgga tatgttgaag aacaccatga

[2234] 421 ctacaaagga gtgtttacat cgtttttgtg cagactgcat catcacagcc cttagaagtg

[2235] 481 gcaacaaaga atgtcctacc tgtcggaaaa aactagtttc caaaagatca ctaaggccag

[2236] 541 acccaaactt tgatgcactc atcagcaaaa tttatccaag tcgtgatgag tatgaagctc

[2237] 601 atcaagagag to holdcc aggatcaaca to cacaata tcagcaagca ctcagtcaca

[2238] 661 gcattgagga aggactgaag atacaggcca tgaacagact gcagcgaggc aagaaacaac

[2239] 721 agattgaaaa tggtagtgga gcagaagata atggtgacag ttcacactgc agtaatgcat

[2240] 781 ccacacatag caatcagga gcaggcccta gtaacaaacg gaccaaaaca tctgatgatt

[2241] 841 ctgggctaga gcttgataat aacaatgcag caatggcaat tgatccagta atggatggtg

[2242] 901 ctagtgaaat tgaattagta ttcaggcctc atcccacact tatggaaaaa gatgacagtg

[2243] 961 cacagacgag atacataaag acttctggta acgccactgt tgatcactta tccaagtatc

[2244] 1021 tggctgtgag gttagcttta gaagaacttc gaagcaaagg tgaatcaaac cagatgaacc

[2245] 1081 ttgatacagc cagtgagaag cagtatacca tttatatagc aacagccagt ggccagttca

[2246] 1141 ctgtattaaa tggctcttt tctttggaat tggtcagtga gaaatactgg aaagtgaaca

[2247] 1201 aacccatgga actttattac gcacctacaa aggagcacaa atgagccttt aaaaaccaat

[2248] 1261 tctgagactg aactttttta tagcctattt cttaatatt aaagatgtac tggcattact

[2249] 1321 tttatggaca gatcttggat atgttgttca atttctttc tgagccagac tagtttacgc

[2250] 1381 tattcaaatc ttttcccctt tatttaagat ttcctttttg gaagggactg caattattca

[2251] 1441 gtattttttt cttccttta aaaaata tctgaagtttt cttgtgtttt ttttttccc

[2252] 1501 cacaaagtgt gtttccactt ggagcaccat tttgacccag gaatttttca tagttctgt

[2253] 1561 attcttataa gattcagttg gctgtccttt tcctgctccc ctcaaaagat ttttagtcat

[2254] 1621 acagaatgtt aaatattatg tattctgact tttttttcc cccggagtct tgtatattta

[2255] 1681 tagttttcta tataaactgt agtatcttca tgaagaccca aggctcaaat ttactgtcct

[2256] 1741 taaaaacaat tctcatagga ttattctttt catggtattt tcttccataa tatctcattt

[2257] 1801 taaaaagaag ttctttatga acttagtgtc cattgtcatg caatgttttt ttttttccat

[2258] 1861 tctttttccc tgtaattttg gaatttctgg tcctgggaag aatcaaacaa aatcttaagt

[2259] 1921 tctatgagaa cttggttcat tgaikatantc tgctgaagaa agaaaaatta aattggtagt

[2260] 1981 aaaatatagt cttcaagtat acgtttgaga gtgctttttt ttgtattagt tctgctgtca

[2261] 2041 cttcatttcc tgtattatat gtgatgtttt tccccattaa aataccagag ataatggaga

[2262] 2101 tattttgcac tttagccttg atgaaaagta caagatatgt tcaaagcttc cctaattttt

[2263] 2161 ttcttatttg tagccacata agtttcaaga ataacatggc acacagaaca atggaaaaaa

[2264] 2221 gtttgtttcc attggaaaat tatatcattt tgggttgcca catcagttta taaatttggc

[2265] 2281 gctcttttaa ttacactctg tagaaggtta atagagcttg agccctgctt tatatgtag

[2266] 2341 tgaaagataa ttctgtagaa aaacgtcagc cagtagggta aagtcattct actgttctta

[2267] 2401 atttttatat tgaggaacaa tattgggtgt ttgggagcca gaaagctttg ttgacagatc

[2268] 2461 agaaataaga ttgacttggg tgttatattt catctctctc cagactctag gtatattcc

[2269] 2521 aactttatat atcacagtat ttaaaaagac atgtttgcat tgagaaatta accctaaagg

[2270] 2581 gttttcaata gggtgtagac ctccagtacc tttgtaacta aagtctgtct agtcattgta

[2271] 2641 aatatttatc tgtcagtttt gacagattgg ggccagcttg atgttttaaa tcttcagccc

[2272] 2701 ggtatgaaaa cttaaaggta tatattcaat ttttaccat tttatggaaa atatttaaaa

[2273] 2761 tctgttttta cagggttttt tttttttttt tttttttgta atctgtgcca tgaaatttga

[2274] 2821 aaaccaccaa aaatcaaggg aacttttata tattcaattc cttttctggt gtaatgttaa

[2275] 2881 agttgtatag attattaatg catgcccact gaatataacc ctggttttgt gataaaactg

[2276] 2941 cttagatttt gttgatgaca ttagattagt agttgcatta aataactaaa ttcccattgt

[2277] 3001 gattaattga aattttgtct ttaagcagag agttatttgt gactataagc tttgtgctta

[2278] 3061 gagaatgtat gtgtttttat ctgtcagtat gggaggatat aaactgcatc attagtgaaa

[2279] 3121 ttattggttg tgtaatcctt tgtgaaatat aattctaggt atttgatagg gtattgagtg

[2280] 3181 tattttgtgt gtgtgtggat gtgtgttttg gggtacgggg agaggcgatg ctattggcca

[2281] 3241 tcactaccaa ccagggtttc aaaaagtatt acctaagtaa tttcttttat cactatctca

[2282] 3301 actgaggaag aaaaggctca ccacaagtgg tgtgaaggct ttgggtactt agttctaaat

[2283] 3361 ttttttatgg taacatatac atagccacat ttacagtttt aaccatttta aggcatgtaa

[2284] 3421 ttcagtgggg ttaggtacat tcacaatgtt gtgtaatgat caccgctgtc tacttgtaaa

[2285] 3481 actttttcat caccccaaac agaaactctg tgtgcaatta aagtaatgca tttctcttct

[2286] 3541 tcttaacccc t (서열 번호 122)

[2287] PHF1 (등록 번호 NM_024165):

[2288] 1 ctccctcccc cccgccgcct cctcctcctg ccgctgccgc tgctttggct gctgcgtcat

[2289] 61 acgccccaga gccgccggga cggaggggct gggcctgggg accccccggc ctccgcctgc

[2290] 121 acgccccccc acgcccggac gtgccctctc cgcgcggggg actcgcctag gtctcctacg

[2291] 181 tctgcccctg cccggctccc ggcggcccca gctgtcaccg gcccccccag gatgcaatgg

[2292] 241 cgcagccccc ccggctgagc cgctctggtg cctcctcact ttgggaccca gcttctcctg

[2293] 301 ctcccacctc tggccccagg cctcggcttt gggagggtca agatgtgctg gccagatgga

[2294] 361 ctgatgggct gctatacttg ggtaccatca aaaaggtgga cagtgctagg gaggtgtgtc

[2295] 421 tggtccagtt tgaggatgat tcgcagtttc tggttctatg gaaagacatt agccctgctg

[2296] 481 ccctccctgg agaggaactc ctctgttgtg tctgtcgctc tgagactgtg gtccctggga

[2297] 541 accggctggt cagctgtgag aagtgtcgcc atgcttatca ccaggactgc catgttccca

[2298] 601 gggctccagc ccctggagag ggagagggca catcctgggt atgccgccag tgtgtctttg

[2299] 661 cgatcgccac caagagggga ggtgccctga agaagggccc ctatgcccgg gccatgctgg

[2300] 721 gtatgaagct ttctctgcca tatggactga aggggctgga ctgggatgct ggacatctga

[2301] 781 gcaaccgaca gcagagttac tgttactgtg gtggccctgg ggagtggaac ctgaaaatgc

[2302] 841 tgcagtgccg gagctgcctg cagtggttcc atgaggcctg cacccagtgt ctgagcaagc

[2303] 901 ccctcctcta tggggacagg ttctatgaat ttgaatgctg tgtgtgtcgc gggggccctg

[2304] 961 agaaagtccg gagactacag cttcgctggg tggatgtggc ccatcttgtc ctgtatcacc

[2305] 1021 tcagtgtttg ctgtaagaag aaatactttg attttgatcg tgagatcctc cccttcactt

[2306] 1081 ctgagaattg ggacagtttg ctcctggggg agctttcaga cacccccaaa ggagaacgtt

[2307] 1141 cttccaagct cctctctgct cttaacagcc acaaggaccg tttcatttca gggagagaga

[2308] 1201 ttaagaagag gaaatgtttg tttggtctcc atgctcggat gcctccccct gtggagcccc

[2309] 1261 ctactggaga tggagcactc accagcttcc cttcagggca gggccctggg ggaggggtct

[2310] 1321 cacgtcccct ggggaagcgc cggaggccgg agccagagcc cctgaggagg aggcagaagg

[2311] 1381 ggaaagtgga ggagctgggg ccaccctcag cagtgcgcaa tcagcccgag ccccaggagc

[2312] 1441 agagggagcg ggctcatctg cagagggcac tgcaggcctc agtgtctcca ccatccccca

[2313] 1501 gccctaacca gagttaccag ggcagcagcg gctacaactt ccggcccaca gatgcccgct

[2314] 1561 gcctgcccag cagccccatc cggatgtttg cttccttcca cccttctgcc agcaccgcag

[2315] 1621 ggacctctgg ggacagtgga cccccagaca ggtcacccct ggaacttcac attggtttcc

[2316] 1681 ccacagacat ccctaaaagt gccccccact cgatgactgc ctcatcttcc tcagtttcat

[2317] 1741 ccccatcccc aggtcttcct agacgctcag cacccccttc tcccctgtgc cgtagtttgt

[2318] 1801 ctcctgggac tgggggagga gtccgaggtg gggttggtta cctgtcccga ggggaccctg

[2319] 1861 tccgggtcct tgctcggaga gtacggcctg atggctctgt gcagtacctg gttgagtggg

[2320] 1921 gaggaggggg catcttctga acagcctgcc tctgcccagc tccccattca cacacaccgg

[2321] 1981 cactttcata ccctgacctc tgacctcacc tacagctggg atgtacctgg agagataggg

[2322] 2041 ggtagttctc cctactgccc aggctggaat ccaagagtgg ggagtgggga agaggccctc

[2323] 2101 ttctctaccc tccttcatga ttcctgaccc ctcccatcct tcccatttcc tttgatgtta

[2324] 2161 ttttgttaca gctttttaaa tattttttaa aattatttaa cccctggggg cagagactga

[2325] 2221 ggagggagga tgataaggga tcccggactc tgtatgattg aaataaagag aaataaacaa

[2326] 2281 atctagcagc tctgaaaaaa aaaaaaaaaa aa (서열 번호 123)

[2327] MTF2 (등록 번호 NM_007358):

[2328] 1 gctgccattc ggcaccggag tcgctccgcg ctcccagaat gcaccggcag tccgcgggaa

[2329] 61 accaaaatgg cgaggggctg tattgaagtg ggctgtgttt gaggccggtg taagaacgct

[2330] 121 cattctaccc ccaacccttg tctccaagga cctcggtttg tgcgtgcata tgtgccgggt

[2331] 181 acccggtggg gcgggtgcc agtaagtgct cggactcgca ggggaagcgc ccacggggac

[2332] 241 ggattggttg ttttttcctg tatgaagcgg ttggcaccac tgaagtgacc gaatgagaga

[2333] 301 ctctacaggg gcaggtaatt cactggtcca caagcggtct cctttacgtc gaaaccaaaa

[2334] 361 gaccccaaca tccttgacca agctgtcttt acaggatgga cataaagcca aaaagccagc

[2335] 421 atgtaaattt gagagggtc aggatgtcct agctagatgg tcagatggct tgttttact

[2336] 481 tgcactatc aaaaagataa acatattgaa acagagctgc ttcatcatat tgagacag

[2337] 541 ttctaatcc tgttctt gcaaggacat tcaacagga gccactgga gtgggaat

[2338] 601 gtctgtaca atgtcaag aagagtattc agaagctccc aatgaatgg ttatatgtga

[2339] 661 caagtgtggc caagtatc atcagttgtg tcacacct catattgatt ccagtgtgat

[2340] 721 tgattcagat gaaaatggc tctgtcggca gtgtgtttt gcaacaacaacaagggg

[2341] 781 tggtgcactt aagaaggac caatgccaa agcattgcaa gtcatgaagc agacattacc

[2342] 841 ctatagtgtg gcagaccttg aatgggatgc aggtcataa accaatgtcc agcagtgtta

[2343] 901 ctgctattgt ggaggccctg gagactgta tttgaagag ctacagtgct gcaatgtaa

[2344] 961 gcagtggttt catgaggctt gtgtgcaatg ccttcaaag ccaatgctat tggagacag

[2345] 1021 attttatacg tttatatgct ctgtctgcag ttctggacca gaatacctca aacgtctacc

[2346] 1081 attacagtgg gtagatatag cacacctatg cctttacaac ctaagtgtta ttcataagaa

[2347] 1141 gaaatacttt gattctgaac ttgagcttat gacatacatt aatgaaaact gggatagatt

[2348] 1201 gcaccctgga gagctggcag acacaccaaa atctgaaaga tatgagcatg ttctggaggc

[2349] 1261 attaaatgat tacaagacca tgttatgtc tgggaaagaa ataaagaaga agaagcattt

[2350] 1321 gtttgggtg cgaattcgtg ttcctcctgt gccaccaaat gtggctttca aagcagagaa

[2351] 1381 agaacctgaa ggaacatctc atgaatttaa attaaaggc agaaaggcat ccaaacctat

[2352] 1441 atctgattca agggaagtaa gcaatggcat agaaaaaaaa ggaaagaaaa aatctgtagg

[2353] 1501 tcgtccacct ggcccatata caagaaaaat gattcaaaaa actgctgagc cacttttgga

[2354] 1561 taaggaatca atttcagaga atcctacttt ggatttacct tgttctatag ggagaactga

[2355] 1621 gggaactgca cattcatcca atacctcaga tgtggatttc acgggtgctt ccagtgcaaa

[2356] 1681 agaaactacc tcgtctagca tttccaggca ttatggatta tctgactcca gaaaaagaac

[2357] 1741 gcgtacagga agatcttggc ctgctgcaat accacatttg cggagaagaa gaggtcgtct

[2358] 1801 tccaagaaga gcactccaga ctcagaactc agaaattgta aaagatgatg aaggcaaaga

[2359] 1861 agattatcag tttgatgaac tcaacacaga gattctgaat aacttagcag atcaggagtt

[2360] 1921 acaactcaat catctaaaga actccattac cagttatttt ggtgctgcag gtagaatagc

[2361] 1981 atgtggcgaa aaataccgag ttttggcacg tcgggtgaca cttgatggaa aggtgcagta

[2362] 2041 tcttgtggaa tgggaaggag caactgcatc ctgactgtag gactgaacat tatgttcact

[2363] 2101 gcactctgat tttctgtagg tacagttcaa agccctaaag gagtctggct tttactatct

[2364] 2161 ttcttaaaaa aaaaaaaaag tcaaaaaaat tcaaaaaagg ggatgatact agccttaaca

[2365] 2221 tgtacctgtc aatgttatgg atattgtcat aaaaaggtat cttttaaaaa tcagaacaga

[2366] 2281 gacttaattt tttaaatctt aagatttgta gaatgtttct aggataggt attaaaatg

[2367] 2341 attgaaccc atgcatggtg ttagacaatt tttctaatta ttccattgag tcagtttttt

[2368] 2401 gtgattagtg attachment caaacatcat gtgattagtg caagtatttg gagaaacgtt

[2369] 2461 gtttgttttg ttaccaaaat gttggaaaaa tttatttcaa taccttttag atttcataaa

[2370] 2521 gtgcagtgta fathergcct actgaaagac tgtaaaatat tgaaatttc tttcaagcaa

[2371] 2581 agtgtaaaaa aatattga gcctgtaaat tgctctgtga ctagacttca ttgtcgtctt

[2372] 2641 fatherttct tgcatgtgca fathercacgtgfather fathergtgtg tgattatgtg

[2373] 2701 acctatgcaa tacaaattat gggaatgggc agctttggag fatherccc ataattcttt

[2374] 2761 tttcaggaat agttgcagta tttacacagc agcattctt ctcaggcttt tattgggtgc

[2375] 2821 tgttgcttgc tatgtatgaa gagaaatgtg tcagacaagt ttagtgtgtt ctgaagaagg

[2376] 2881 gtgtgaacaa cagtgttcat gggcttttag aatgcttttc acttttagtc cttgtaactc

[2377] 2941 agctgttcag tacctaaaac aaattcaaat aatatgaaca ttatctccta ctagaagtaa

[2378] 3001 cgttttcaaag ttttcatggc acattatgat tgtaaatgtc tctcattttt aacagtaagt

[2379] 3061 ctataggagt cccgtgaaga ttcctgaaat gtctgtagta actgttagtc atgtttgaat

[2380] 3121 aagtgtagta tgaacaaagt attttattgc acagggttaa caaacagtat gttgccagct

[2381] 3181 gaggctactg ctgttttatt acaacattac ctcttgtttt tataaagtgt accaagattt

[2382] 3241 aaattgataa ctttatttta cttgtaaaaa aaaagtttct tttatcacca gtgttacagt

[2383] 3301 tgtcttctgt ttctttttgt tttgttttat ttgttttcct ttttagccaa agagtgaaca

[2384] 3361 gaagattttc ttattttggt ggctattcat tttactttta aaagtgattg gtggatttta

[2385] 3421 gactaattat gggggaattt gccaccaaaa taaaaaat gtaaagtgta gtgattacag

[2386] 3481 agtggttaaa atgtgggtta gtacttattt attccattaa ttgattattt gactgttat

[2387] 3541 aaagaaagtt gctttattc tttaaacatc ttcaaaagat gatcctttct tgtcacatta

[2388] 3601 tagccaaaag aagcagagaa cttcattgtc tgcatttggt tcctggttgg ccaggtataa

[2389] 3661 atgagcttta caaaagtgca attaaaaac tgttacttct gtttacctcc accaaaactt

[2390] 3721 gattttcccc tagctattaa tttaaggttg cctttcctgc agctgcaata ttttgaataa

[2391] 3781 cacacagagt ttgtgttgat ttttgaatgt ttgtttatat ctaggggtaa tgaaaaatgt

[2392] 3841 aaatcccgtg tatccttatt cactccacct gtatcatatt atttcatttt ccccaaagtc

[2393] 3901 cttaattct aactgaacac cagcagtatt tttagaaatt ttctttaac atacttggaa

[2394] 3961 gatgattat ccagctgaac tgtctttaga cgtaattatt gtgaatgtct gttttatttt

[2395] 4021 ctcatggtgg ttcacatggc tctgatgttc agttgtatt ttggaattg cttacttag

[2396] 4081 aaattaaaac agaccaacat taaatgtgtg tattttttaa agagctaaaa aaaaaaaaa

[2397] 4141 aaaa (서열 번호 124)

[2398] PHF19(등록 번호 NM_001286840):

[2399] 1 accagtaagt cgtgtattta gcattcattc atcaaagcct ccggatgcct cctacgtgcc

[2400] 61 ctgcactatg ctggtcttgg taatccgtgg tccctatccc agcgcccagt gtcaggggaa

[2401] 121 gctgatggag aatcgagctc tggatccagg gactcgggac tcctatggtg ccaccagcca

[2402] 181 cctccccaac aagggggccc tggcgaaggt caagaacaac ttcaaagact tgatgtccaa

[2403] 241 actgacggag ggccagtatg tgctgtgccg gtggacagat ggcctgtact acctcgggaa

[2404] 301 gatcaagagg gtcagcagct ctaagcaaag ctgcctcgtg actttcgaag ataattccaa

[2405] 361 atactgggtc ctatggaagg acatacagca tgccggtgtt ccaggagagg agcccaagtg

[2406] 421 caacatctgc ctagggaaga catcagggcc gctgaatgag atcctcatct gcgggaagtg

[2407] 481 tggcctgggt taccaccagc agtgccacat ccccatagcg ggcagtgctg accagcccct

[2408] 541 gctcacacct tggttctgcc gacgctgcat cttcgcactg gctgtgcgga aaggcggcgc

[2409] 601 gctgaagaag ggcgccatcg ccaggacgct gcaggccgtg aagatggtgc tgtcctacca

[2410] 661 gcccgaggag ctcgagtggg actcgcccca tcgcaccaac cagcagcaat gctactgcta

[2411] 721 ctgcggcggg cccggagaat ggtacctgcg gatgctgcaa tgttaccggt gcaggcagtg

[2412] 781 gttccacgag gcctgcaccc agtgcctcaa tgagcccatg atgtttggag accggtttta

[2413] 841 cctgttcttc tgctccgtgt gtaaccaggg cccagagtac atcgagaggc tgcccctgcg

[2414] 901 atgggtggat gtggttcacc tggccctcta taatctgggg gtacagagca agaagaagta

[2415] 961 ctttgacttt gaggagattc tggcctttgt caaccaccac tgggagctcc tgcagcttgg

[2416] 1021 caagctcacc agcaccccag tgacagatcg aggaccacat ctcctcaacg ctctgaacag

[2417] 1081 ttataaaagc cggttcctct gcggcaagga gatcaagaag aagaagtgca tcttccgcct

[2418] 1141 gcgcatccgc gtcccaccca acccgccagg gaagctgctg cctgacaaag gactgctgcc

[2419] 1201 aaatgagaac agcgcctcct ctgagctgcg taagagagga aagagcaagc ctggtttgtt

[2420] 1261 gcctcacgaa ttccagcagc agaaaaggcg agtttataga agaaaaagat caaagttttt

[2421] 1321 gctggaagat gctattccca gtagtgactt cacctcagcc tggagcacca accaccacct

[2422] 1381 ggctagcata tttgacttca cgctggatga aattcaaagt ttaaaaagtg ccagctcagg

[2423] 1441 ccagaccttc ttctcagatg tcgactccac cgacgctgcc agcacctctg gctctgcctc

[2424] 1501 caccagcctc tcctatgact ccagatggac agtgggcagc cgaaagagga agctggcagc

[2425] 1561 caaggcatac atgcccctgc gggcaaagcg gtgggcagct gagctggatg gacgctgccc

[2426] 1621 ctcggacagc agtgcagagg gggcttcagt ccccgagcgg ccagacgaag gcattgacag

[2427] 1681 ccacacattt gagagcatca gtgaagatga ctcatccctg tcccacctca agtcatctat

[2428] 1741 caccaactac tttggtgcag ctgggcggtt ggcctgtggg gagaagtacc aggtgttggc

[2429] 1801 tcggagggtc acacctgagg gcaaggttca gtacctggtg gagtgggaag ggaccacccc

[2430] 1861 ttactgacta gcccccgggg gtgccagggg tcctgaaaac caaaggagga gcagcagaag

[2431] 1921 ccataggctc cccagctttc tccaggctgg ggtgggagaa ggaagcagga cagagctgca

[2432] 1981 agtgcctggc agaatgccct gcctgcctgc ctgccaggcc aaggcctgcg tctctctgct

[2433] 2041 gtaccagctc tgttccaggg cctcctcagg ctcgttaccc ctgtgcctgt gtctctacac

[2434] 2101 actccacacc ccctcaaact ctgtttatct gttctctgac cttgtgtccc ctgcgctggg

[2435] 2161 acccttcctc ctgaggccca ggtctttgtc cccagttgtg tgccttgacc tctctcgccc

[2436] 2221 ctttctgggt gtgttcgcac atcctgtgtg tgcacagctg tccctccact ggatcccctt

[2437] 2281 cacacgtgac ccgtggggca gccagtcctc ccagggacta cataacaggc acctttgaga

[2438] 2341 gagcatggga gaaggtggat aagaggatgc tgctcagtgc tttctcttc cactttcctg

[2439] 2401 ccactcccca ctaccctcgg agagaggtgg tgggatggga gagagcccct gtgaaagcct

[2440] 2461

[2441] 2521 ggtattaagg ctgagagtga aggctgccaa tgtcagcttt ggaggtccca gaagtcttct

[2442] 2581 gttctctggc ctcaccccct cagtcgccat agagctgggc ctggccttgc tggaatggag

[2443] 2641 gcatccttcc aaacctgggg gacgggggtg gggggtggta gtggtgggag ggaaccatg

[2444] 2701 tcttgctaaa cctgtttctg gtgcctccca tccccagacc caccagacac cacacagcag

[2445] 2761 acaatacaca cccactcgca caagcttcca tccacatgtg ttgtactttc agctctaggc

[2446] 2821 atgcagacaa ccccacacgg ccacaccacc acatgcccaa gtgtacacac acagagccac

[2447] 2881 accgtccctc tgggcctgct ggctcctccc ttggctttcc cttggcccac ttccagggcc

[2448] 2941 caggtgctgc aactaaatgt gaaagctcag tggccgctcc ttctttcagc ccatcaacca

[2449] 3001 gcattggtcc catagggaag cacaggggac tcaccctctt tcatatccct tgccctgccc

[2450] 3061 tgaaatggac aatcactttt tgggataggt tgaaattttt aaagagcctg catcatttgg

[2451] 3121 ttccctcaaa gggaagccct tgccagtggg ggtttgaaag agaatttttg gaaccaacat

[2452] 3181 tcaaattctg cctcatctgg agggaaacca aaattgggag ggggaagagg acccctgatg

[2453] 3241 ttttgctgct tccagagata ttagaaactg actcacttga ttggaaaatg gacaaaagtg

[2454] 3301 ccttgacgtg gagggtgggc accagatggg gaccagcctt gccaactgct gctgtggcct

[2455] 3361 ccagcttggc tggttttgca ggccgccagc aggaaggcga aggtggtagt acagcaagag

[2456] 3421 gcactggcgg ggcagcaggc ctgcaggagc tgtttttcca ttgctaggcc tgacccctct

[2457] 3481 ctacctgtga gcgttcaggg ggtccctgag atagtttaga tgccccccca tcttagacct

[2458] 3541 cagctcccac agtgcctttt aagggggacc tcacctcctg tgcacagccc acccactttc

[2459] 3601 ctctgcttcc ctggcacagc ccaggcatag acgagctggc gttggaccca gttcttcccc

[2460] 3661 cttttcagcc ccacagctgc tgccacaggg gccaactagg gccaggtgga aggggagctg

[2461] 3721 agaagccaac ccctagccca ggggtgctgt gggaactggg atccaatttg tagcttcctg

[2462] 3781 cctggcttca gagagcccag caaccttcta ggcctgcttt ccagacttct gagatagcct

[2463] 3841 gggatgagca atcctgttat agtacatctg gaccttccct acctgggctc tggggaggct

[2464] 3901 gtgggcctgg agagggaaaa ggagggaggg ggtgtctgca ccacctggga agatagcaca

[2465] 3961 aggcctaatg aggtcaccct gactccccac cccagcattt cattcatacc agataatagc

[2466] 4021 tgcattactg ccaactgacc ttataaccct ctgcaccttc aaaaagattc atggtttta

[2467] 4081 attgctgctt ttaataacat ttgttaaagt tataattaat gtgtctgatt tatgatttaa

[2468] 4141 aacctccctt tgaacaatca aaaaaaaaaa aaaaaaaaa a (서열 번호 125)

[2469] SETD1A(등록 번호 XM_005255723):

[2470] 1 agtggtgttt ggtgcgcgcg ccggggaggt ggtggtgggg gggcgccgcc gccgccaccg

[2471] 61 ctgcggggcc gggtctcgcg ctgccgctgc cgcgcccg cgcgctgag gtgcgcgcg

[2472] 121 aggtgggggg agggggagcc gctcgccggg agcggtgtaa atgagcaaag atggatcagg

[2473] 181 aaggtgggggg agatgggcag aaggccccga gcttccagtg gcggaactac aagctcatcg

[2474] 241 tggatcctgc cttggaccct gcctgcgca ggccttctca gaaggtgtac cgctatgatg

[2475] 301 gagtccactt cagtgtcaac gactcaaagt atataccagt cgaagacctc caagaccccc

[2476] 361 gttgccatgt caggtccaaa aacagagact tttccctccc agtccctaag tttaagctgg

[2477] 421 acgagttcta tattggacag attccactga aggaagtgac ttttgcaagg ctgaatgaca

[2478] 481 acgtgcggga gaccttcctg aggattatgt gccgtaagta cggtgaggtg gaagaggtag

[2479] 541 agatcctcct tcaccccgt acgcgcaagc acctgggcct ggcccgtgtg ctcttcacca

[2480] 601 gcactcgggg cgccaaggaa acggtcaaaa acctccacct tacctccgtc atgggcaaca

[2481] 661 tcatccatgc ccagcttgac atcaaaggac aacaacgaat gaaatactat gaactaattg

[2482] 721 tcaatggctc ctacacccct cagactgtgc ccactgggg caaggccctg agtgagaagt

[2483] 781 tccaaggctc gggtgcagcc actgagacgg ccgaatcccg ccgccgctct tcctctgaca

[2484] 841 cagctgccta cccagcaggc accactgcgg tgggcactcc tggcaacggc acccccttgct

[2485] 901 cccaggacac aagcttctcc agcagccgac aagatacccc atcttccttt ggccagttca

[2486] 961 cacctcagtc ctcccaagga accccctaca cgtctcgggg cagcacccc tactctcagg

[2487] 1021 actctgccta ctccagcagc accacttcaa cctccttcaa gccccggcgg tcagagaaca

[2488] 1081 gctaccaaga tgccttttcc cgccgccact tctctgcatc ttcagcctcc acaaccgcct

[2489] 1141 ccacggccat cgccgccacc actgcagcca ctgcctcatc ctccgcctct tcctcctcat

[2490] 1201 tgtcctcgtc ctcctcgtca tcctcttcct cctcgtcctc tcagtttcgt agttctgatg

[2491] 1261 caaactaccc agcgtattat gaaagctgga atcgctacca gcgccatact tcctacccac

[2492] 1321 cacgccgggc cacacgggag gaaccccctg gagccccttt tgctgaaaat acagctgagc

[2493] 1381 gcttcccacc ttcttacacc tcctacctgc cccccgagcc cagccggccc accgaccagg

[2494] 1441 actaccggcc tcctgcctca gaggctccac ccccggagcc tccagaacct ggtggaggcg

[2495] 1501 ggggtggagg agggcccagc cctgagagag aagaagttcg gacttccccc cgcccagcct

[2496] 1561 cccctgcccg ctctggctcc ccagccccgg agaccaccaa tgagagtgtg cccttcgccc

[2497] 1621 cctggattcc cgcatcgaga tgctgctga ggagcgc tccaagtttt

[2498] 1681 ccttcttggc ctctgacaca gaggaggagg aagagaacag cagcatggtc cttggggcca

[2499] 1741 gagatacagg gagtgaggtg ccttctgggt cagggcatgg gccctgcaca ccccctccgg

[2500] 1801 ccccagctaa ttttgaggat gtggcaccta cagggagcgg ggagccaggg gctacccggg

[2501] 1861 agtctcccaa ggcaaatgga cagaaccagg cttctccatg ctcttctgga gacgacatgg

[2502] 1921 agatctccga cgacgaccgg ggtggctcac cccctccggc cccgacgccc cctcagcagc

[2503] 1981 ctccgccacc tccccctccc ccgccgcctc ctcctcccta cctggcgtcc cttcctcttg

[2504] 2041 gttatcctcc ccaccaacct gcctacctcc tcccacccag acctgatggg ccgccgcccc

[2505] 2101 ctgagtaccc cccacctcct ccaccacccc cgcacatcta tgactttgtg aactccttgg

[2506] 2161 agctcatgga ccgacttggg gctcagtggg gaggatgcc catgtccttc cagatgcaga

[2507] 2221 cccagatgtt aactcggctc catcagctgc ggcagggcaa gggattgatt gccgctccag

[2508] 2281 ctggcccccc cggtggggcc tttgggggagg ccttctccc gtttccaccc ccgcaggagg

[2509] 2341 cagcctacgg cttgccgtat gctctatatg cacaggggca ggagggcaga ggggcatact

[2510] 2401 cacgggaggc ctaccacctg cccatgccaa tggcagccga gcccctgccc tcctcctcag

[2511] 2461 tctcgggaga ggaggcccgg ctgccaccca gggaagaagc agagctggca gagggcaaga

[2512] 2521 ccctcccgac agcaggcacc gtgggccgtg tgctcgccat gctggtccag gagatgaaga

[2513] 2581 gcatcatgca gcgagacctc aaccgcaaga tggtggagaa cgtggccttc ggagcctttg

[2514] 2641 accagtggtg ggagagcaag gaggaagg ccaagccatt ccagaacgcg gccaagcagc

[2515] 2701 area

[2516] 2761 tggactgggc caagagcggg ggcactacgg gcatcgaggc tttcgccttt gggtcagggc

[2517] 2821 tgagaggggc cctgcggctg ccttcattca aggtaagcg gaagagcca tcggaattt

[2518] 2881 ccgaggccag tgaggaaag aggctcgtc cctccactcc tgctgaggaa gatgaagacg

[2519] 2941 accctgaaca agagaggag gctggagagc caggacgtcc ggggaccaag cccccgaagc

[2520] 3001 gggacgaga gcgaggcaag acccaggggca agcaccgca gtcctttgct ctggacagcg

[2521] 3061 aggggagga gcatcccag gagtcctcct cggagagga tgaggagat gacgaggaag

[2522] 3121 atgaggaga tgagatcga gaggaagctg tggataccac aaagaggag acagaggtgt

[2523] 3181 cggatggcga ggacgaggaa agcgattcgt cttccaatg ttctgtat gctgactcag

[2524] 3241 atggcgaaaa tgacagcaca tcagactccg agagcagcag ctctccagc tcctcatcct

[2525] 3301 cctcctcctc ctcgtcctca tcctcctcgt cctctcatc ctctgagtcc tcctctgaag

[2526] 3361 atgagagga agaggagcgg ccagcagcccc ttccctcagc ctccccccc cccagagaag

[2527] 3421 tcccagtgcc cacgccagca cctgtggagg tgccagtgcc ggaaagggtt gcaggctccc

[2528] 3481 cagtcacacc cctgcccgaa caggaggcgt ctccagcaag gcctgcaggc cccacggagg

[2529] 3541 agtcaccccc cagtgcgcct ctgcgtcccc cagaaccacc tgctgggccc ccggcccctg

[2530] 3601 ccccacgccc cgatgagcgt ccctcttctc ccatccccct cctgccccca cccaagaaac

[2531] 3661 gccggaaaac tgtctccttc tctgccatcg aggtggtgcc agccccggag ccccctccag

[2532] 3721 ccacaccgcc gcaggccaag tttcccggcc cagcctcccg caaggctccc cggggcgtgg

[2533] 3781 agcggaccat ccgcaacctg cccctggacc acgcatctct ggtcaagagt tggcccgagg

[2534] 3841 aggtgtcccg aggaggccgg agccgggctg gaggccgagg ccgcctcacc gaggaagagg

[2535] 3901 aggctgagcc agggacagag gtggacctgg cggtcctggc cgacctggcc ctgacccctg

[2536] 3961 cccggcgcgg gctgcctgcc ctgcctgctg ttgaagactc agaggccaca gagacatcgg

[2537] 4021 acgaggccga gcgccctagg cccctgctca gccacatcct cctggagcac aactatgccc

[2538] 4081 tggccgtcaa gcccacgccc cctgcgccag ccctgcggcc cccggagcca gtgcccgcac

[2539] 4141 ccgccgccct cttcagttcc ccagctgatg aggtcctgga ggcccccgag gtggtggtgg

[2540] 4201 ctgaggcgga ggagcccaag ccgcagcaac tgcagcagca gcgggaggag ggcgaagagg

[2541] 4261 agggggagga agagggggag gaagaggagg aggagtcctc tgacagcagc agcagcagcg

[2542] 4321 atggggaggg cgccctccgg aggcgcagcc tccgctccca cgcccggcgc cgccgccctc

[2543] 4381 cgcccccacc cccgccgcca ccgccccgcg cctacgagcc acgcagtgag tttgaacaga

[2544] 4441 tgaccatcct gtatgacatt tggaactcgg gcctggactc agaggacatg agttacctgc

[2545] 4501 ggcttacgta cgagcggctg ctgcagcaga caagcggggc tgactggctc aacgacactc

[2546] 4561 actgggtcca tcacacaatc accaacctga ccaccccaaa acgcaagcgg cggccccagg

[2547] 4621 atgggccccg ggagcaccag acaggctcag cccgcagcga aggctactac cccatcagca

[2548] 4681 your area ggaagtac ctggacgtgt gcccagtctc ggcccggcag ctggagggcg

[2549] 4741 tggacactca ggggacgaac cgcgtgctgt ccgagcgccg gtccgagcag cggcggctgc

[2550] 4801 tgagcgccat cggtacctcc gccatcatgg acagtgacct gctgaaactc aaccagctca

[2551] 4861 agttccggaa gaagaagctc cgatttggcc ggagccggat ccacgagtgg ggtctgtttg

[2552] 4921 ccatggaacc cattgctgct gacgagatgg tcatcgaata cgtgggtcag aacatccgtc

[2553] 4981 agatggtggc cgacatgcgg gagaagcgct acgtgcagga gggcattggc agcagctacc

[2554] 5041 tgttccgggt ggaccacgac accatcatcg atgccaccaa gtgtggcaac ctggccagat

[2555] 5101 tcatcaacca ctgctgcacg cctaactgct acgccaaggt catcaccatc gagtcccaga

[2556] 5161

[2557] 5221 acaagttccc actggaagac aacaagatcc cgtgtctgtg tggcacagag agctgccggg

[2558] 5281 gctccctaaa ctgaggtggg gcaggatggg tgcccacacc cctatttatt ccccctggtg

[2559] 5341 ccctgagctc ccagcacccc cccagcctta gtgggctcag cagggcccac atgcccccat

[2560] 5401 ctccaagcgt ggggttgggg gccccaagcc cagcgaggga gcctcagtcc ctggaggcag

[2561] 5461 cttctgcctc tcctgtcacc cctgcccacc accccctgat tgtttttctt tgcggagaag

[2562] 5521 aagctgtaaa tgttttgtag cagccagcag ctgtttcctg tggaaacctg gggtgccggc

[2563] 5581 ctgtacagat tctgtcctgg ggggctacac agtcctcttg ctttgtgtta atggggactt

[2564] 5641 ccccttacgc cctgcgtgta cccctcccca gtttaggggt ctctggggca gtggccatgt

[2565] 5701 tctccccctg ggggggctct gcacccccag tcctggggac tccgtgcctg gaaccctgcc

[2566] 5761 tcatctgttc ctgccagacc ctgagggtca cccttccacc ctggtgtcac tccccggctc

[2567] 5821 agccaggcca ggatggcggg gtgggtccct tttgctgggc tggactgtac atatgttaat

[2568] 5881 agcgcaaacc cgacgccaca tttttataat tgtgattaaa ctttattgta caaaa (서열 번호 126)

[2569] SETD1B(등록 번호 NM_015048):

[2570] 1 aacggcatgg agaacagtca ccccccccac caccaccacc agcagccccc gccgcagccc

[2571] 61 ggcccttcgg gcgagaggag gaaccaccat tggagaagtt acaagttgat gattgacccg

[2572] 121 gctctgaaaa aggggcatca taaactgtac cgctacgatg ggcagcattt cagcctggcg

[2573] 181 atgtccagca accgcccggt ggaaattgtc gaagatcccc gggtcgtcgg gatctggacc

[2574] 241 aaaaacaagg agctggagct gtcggtgccc aaattcaaga tcgatgagtt ctacgtgggc

[2575] 301 ccggtgcctc cgaagcaggt gacatttgcc aagctgaatg ataacatccg tgaaaacttc

[2576] 361 ctgagggaca tgtgcaagaa gtatggggag gtggaggagg tggagatttt gtacaacccc

[2577] 421 aagaccaaga agcacctggg catcgccaag gtggtctttg ccacggtccg gggagccaag

[2578] 481 gatgccgttc agcacttgca cagcacttcc gtcatgggca acattatcca cgtggagctg

[2579] 541 gacaccaaag gggaaacccg aatgcggttc tatgaactgt tggtcactgg ccgatacacc

[2580] 601 ccccagaccc tcccagtggg cgagctggac gctgtctctc caatcgtgaa tgagaccctg

[2581] 661 cagctgtcag atgccctgaa gcgcctcaag gatggaggcc tgtctgcagg ctgtggctcc

[2582] 721 ggctcctcct ctgtcacccc caatagcggt gggacaccct tctcccagga cacagcttat

[2583] 781 tccagctgcc gcctggacac acccaactcc tatggacagg gcaccccgct cacaccgcgc

[2584] 841 ctgggcaccc ctttctcaca ggactccagc tactccagcc gccagcccac accctcatac

[2585] 901 ctcttcagcc aggaccctgc agtgaccttc aaggcccggc gccacgagag caagttcacg

[2586] 961 gacgcctaca accgccgcca cgaacatcat tatgtacaca attctcccgc ggtcactgcg

[2587] 1021 gtggccgggg ccacagccgc tttccggggt tcctcggacc tcccgttcgg agcagtcggc

[2588] 1081 ggcactgggg gcagcagcgg tcccccgttc aaggctcaac cacaggattc agccacattt

[2589] 1141 gcccacactc caccacccgc ccaagcaacc cctgctcctg gattcaagtc tgctttctct

[2590] 1201 ccgtatcaga ccccagtggc ccacttccct ccacccccgg aagagcccac cgccacagcc

[2591] 1261 gcttttgggg cccgcgacag tggggagttc cggagggcac cggcgccccc acccctgcca

[2592] 1321 cctgctgagc ctctggccaa ggagaagcca ggcacgccac ccggcccgcc gccccccgac

[2593] 1381 accaacagca tggagctggg cggccggccc accttcggct ggagtcctga gccctgtgac

[2594] 1441 agccctggca cgcccacgct ggagtcgtcc cctgcagggc cagagaaacc ccacgacagc

[2595] 1501 ctggactcgc gcatcgagat gctgctgaag gagcagcgca ccaagctgct cttcctgagg

[2596] 1561 gagccggact cggacaccga gctgcagatg gagggcagcc ccatctcctc ctcctcctcc

[2597] 1621 cagctctccc cactggcccc ctttggcacc aactcccagc caggcttccg gggccccacg

[2598] 1681 cccccctcgt cacgcccctc cagcaccggc ctggagagata tcagcccaac acccctccca

[2599] 1741 gactccgacg aggacgagga gctcgacctg ggccttgggc ctcggcctcc acctgagcca

[2600] 1801 ggccccccgg accctgctgg gcttctgagc cagacagctg aggtggcctt ggacctggtt

[2601] 1861 ggagacagaa ccccgacctc agaagaagtg gatgagggcc agcagtcctc aggcgaggac

[2602] 1921 atggagatct cggatgacga gatgccctcg gcccccatca ccagcgctga ctgccccaag

[2603] 1981 cccatggtgg tgaccccagg agcggcagcc gtggcagccc cttctgtgct agccccaaacc

[2604] 2041 ctgccgctgc ccccgccacc tggcttcccc ccgctgcccc ccccaccacc accaccccca

[2605] 2101 ccgcagcctg gcttccccat gcccccaccg ctgcccccac cgccgcccccc accccctcca

[2606] 2161 gcccaccctg ctgtgacagt gcccccacca cccttgccag cgccgcctgg agtcccgccc

[2607] 2221 ccacccatcc tgccaccact gccccccttt ccgccgggcc tgttccctgt gatgcaggtg

[2608] 2281 gacatgagcc acgtgctggg tggccagtgg ggcggcatgc ccatgtcctt ccagatgcaa

[2609] 2341 acgcaggtgc tcagccggct gatgacgggc cagggcgcct gcccctaccc gcccttcatg

[2610] 2401 gccgctgcgg ccgccgctgc ctcagctggg ctccagtttg tcaacctgcc gccctaccgg

[2611] 2461 ggccccttct ccctgagcaa ctccggccca ggccgcgggc agcactggcc accactgccc

[2612] 2521 aagtttgacc cgtcagtgcc tccaccaggc tacatgccac gccaggagga cccacacaaa

[2613] 2581 gccacggtgg atggcgtcct gctggtggtc ctcaaagaac tcaaggccat catgaagcgt

[2614] 2641 gacctgaacc gcaagatggt ggaagtggtg gctttccggg cctttgacga gtggtgggac

[2615] 2701 aagaaggagc ggatggccaa ggcctcgctg accccggtga agtcgggcga gcacaaggac

[2616] 2761 gaggacaggc cgaagcccaa ggaccgcatc gcctcgtgcc tgctggagtc atggggcaag

[2617] 2821 ggcgagggcc tgggctacga gggcctgggc ctgggcattg ggctgcgtgg ggccattcgc

[2618] 2881 ctgccctcct tcaggtca gaggaggag ccaccagaca ccacctc tggcgaccag

[2619] 2941 aagcggctgc ggccctcgac ctctgtggat gaggagatg aagagtccga gcgagagcga

[2620] 3001 gaccgggata tggcagacac cccctgtgag ctcgccaagc gggacccca gggcgtgggt

[2621] 3061 gtgcggcggc ggccggcgcg gcctctggag ctggacagtg gtggggagga ggacgagag

[2622] 3121 gagtcattgt cggaggaacca ggagagcacc gaggaggaag aggaggga ggaggagga

[2623] 3181 Gaggaggag gagggacga tgacgacagt gagaccgggg gagagtctga gaacgatgac

[2624] 3241 gaggacacag ccctgtcaga ggcgagtgag aaggacgag gggactcgga tgagaggag

[2625] 3301 acagtgagca ttgtaacctc aaggccgaa gccacgtcgt acagtgagag ttccgagtct

[2626] 3361 tctgagttg agtcaagctc cgagtcctcg ccccatcct cggaggatga ggaggaggta

[2627] 3421 gtggccaggg agaggagga agagaggag gaggagaga tggtggccga ggaagcatg

[2628] 3481 gcttctgcag gccctgagga ctttgagcag gacggggagg aagcggctct ggccccgggg

[2629] 3541 gcacctgcag tggactcgtt gggcatggaa gaggaggtgg acatcgagac tgaggctgtg

[2630] 3601 gcccctgagg agcggccctc catgctggac gagcccccct tgcctgtggg tgttgaagag

[2631] 3661 ccagcggact ccagggagcc gcctgaggaa ccaggcctga gccaggaagg ggccatgttg

[2632] 3721 ctgtctccag agccccctgc caaggaggtg gaggctcgac cccacattgtc ccctgagcga

[2633] 3781 gctccagaac atgacctgga agtggagccg gagcccccta tgatgctccc cttgccgctg

[2634] 3841 caaccaccat tgccgccccc acgaccaccc cggccaccca gcccaccgcc ggagcctgag

[2635] 3901 accacagatg cctcacaccc atctgtccct ccggagcccc ttgccgagga ccaccccccg

[2636] 3961 catactccag gcctctgtgg cagcctggcc aagtcgcaga gcacagagac ggtgccagcc

[2637] 4021 acaccaggcg gggagcccc gctatcaggg ggcagcagtg gcctgtccct gagctctccg

[2638] 4081 caagtgcccg gcagcccctt ctcctaccca gccccgtccc ctagcttgag cagtgggggc

[2639] 4141 ctccctcgga cacctggccg ggacttcagc ttcacaccca ccttctccga gcccagcggg [264...

Claims

Claim 1 Salmonella enterica Salmonella enterica A Salmonella enterica bacterial cell comprising a) a SseJ deletion; and b) a lysate gene or lysate cassette operably linked to an intracellularly induced Salmonella promoter, wherein the intracellularly induced Salmonella promoter is a promoter for one of the genes of the Salmonella pathogenic islet type III secretion system (SPI2-T3SS) selected from SpiC or SsaB, SseF, SseG, SseI, SseJ, SseK1, SseK2, SifA, SifB, PipB, PipB2, SopD2, GogB, SseL, SteC, SspH1, SspH2, or SirP group. Claim 2 In claim 1, the lysis cassette is a cell, which is a lysine E from phage phiX174, a lysis cassette from phage iEPS5, or a lysis cassette from lambda phage. Claim 3 In claim 1, the cell is a cell that does not contain endogenous flhDC expression. Claim 4 In claim 1, the cell is a cell that does not contain endogenous flhDC, motA, motB, flhE, cheZ, cheY, cheB, cheR, cheM, cheW, cheA, fliA, fliY, fliZ, fliB, fliS, fliE, fliF, fliJ, fliL, fliM, fliN, fliO, flip, fliQ, fliR, fliG, fliH, fliI, fliT, fliD, fliC, fljB, ycrG, flgN, flgM, flgA, flgB, flgC, flgD, flgE, flgF, flgG, flgH, flgI, flgJ, flgK, or flgL expression. Claim 5 In claim 1, the cell comprises an exogenous inducible promoter operably linked to an endogenous or exogenous flhDC, motA, motB, flhE, cheZ, cheY, cheB, cheR, cheM, cheW, cheA, fliA, fliY, fliZ, fliB, fliS, fliE, fliF, fliJ, fliL, fliM, fliN, fliO, flip, fliQ, fliR, fliG, fliH, fliI, fliT, fliD, fliC, fljB, ycrG, flgN, flgM, flgA, flgB, flgC, flgD, flgE, flgF, flgG, flgH, flgI, flgJ, flgK, or flgL gene. Claim 6 In paragraph 5, the exogenous inducible promoter is operably linked to an endogenous flhDC, motA, motB, flhE, cheZ, cheY, cheB, cheR, cheM, cheW, cheA, fliA, fliY, fliZ, fliB, fliS, fliE, fliF, fliJ, fliL, fliM, fliN, fliO, flip, fliQ, fliR, fliG, fliH, fliI, fliT, fliD, fliC, fljB, ycrG, flgN, flgM, flgA, flgB, flgC, flgD, flgE, flgF, flgG, flgH, flgI, flgJ, flgK, or flgL gene, in a cell. Claim 7 In paragraph 5, the exogenous inducible promoter is operably linked to an exogenous flhDC, motA, motB, flhE, cheZ, cheY, cheB, cheR, cheM, cheW, cheA, fliA, fliY, fliZ, fliB, fliS, fliE, fliF, fliJ, fliL, fliM, fliN, fliO, flip, fliQ, fliR, fliG, fliH, fliI, fliT, fliD, fliC, fljB, ycrG, flgN, flgM, flgA, flgB, flgC, flgD, flgE, flgF, flgG, flgH, flgI, flgJ, flgK, or flgL gene, in a cell. Claim 8 In paragraph 5, the exogenous inducible promoter comprises the arabinose inducible promoter PBAD (L-arabinose), LacI (IPTG), salR, or nahR (acetylsalicylic acid (ASA)), in a cell. Claim 9 In claim 1, the cell comprises a plasmid expressing a peptide. Claim 10 In paragraph 9, the above peptide is a therapeutic peptide, a cell. Claim 11 In claim 9, the peptide is NIPP1 or an activated caspase 3, a cell. Claim 12 A composition for treating cancer comprising a population of bacterial cells of claim 1 and a pharmaceutically acceptable carrier. Claim 13 A composition for colonizing intratumoral cells in a subject requiring colonization of intratumoral cells, comprising a population of bacterial cells of claim 1. Claim 14 A composition in which, in Clause 13, the tumor cells are tumor immune cells or tumor stromal cells. Claim 15 A composition for treating cancer in a subject requiring treatment for cancer, comprising a population of bacterial cells of claim 1. Claim 16 A composition for inhibiting tumor growth or proliferation or reducing the volume or size of a tumor in an object requiring inhibition of tumor growth or proliferation or reduction of the volume or size of a tumor, comprising a population of bacterial cells of claim 1. Claim 17 A composition for treating metastases, reducing the formation or number of metastases, or inhibiting the spread of metastases in a subject requiring treatment of metastases, reduction of the formation or number of metastases, or inhibition of the spread of metastases, comprising a population of bacterial cells of claim 1. Claim 18 A composition according to any one of claims 14 to 17, wherein the tumor, tumor cell, cancer, or metastasis is a lung, liver, kidney, breast, prostate, pancreas, skin, colon, head and neck, ovarian, or gastrointestinal tumor, tumor cell, cancer, or metastasis. Claim 19 A composition according to any one of claims 14 to 17, wherein the bacterial cell delivers a therapeutic peptide to the tumor, tumor cells, cancer, or metastasis. Claim 20 A composition according to any one of claims 14 to 17, wherein the endogenous expression of flhDC, motA, motB, flhE, cheZ, cheY, cheB, cheR, cheM, cheW, cheA, fliA, fliY, fliZ, fliB, fliS, fliE, fliF, fliJ, fliL, fliM, fliN, fliO, flip, fliQ, fliR, fliG, fliH, fliI, fliT, fliD, fliC, fljB, ycrG, flgN, flgM, flgA, flgB, flgC, flgD, flgE, flgF, flgG, flgH, flgI, flgJ, flgK, or flgL is regulated by an exogenous inducible promoter. Claim 21 In any one of paragraphs 14 through 17, flhDC , The expression of motA, motB, flhE, cheZ, cheY, cheB, cheR, cheM, cheW, cheA, fliA, fliY, fliZ, fliB, fliS, fliE, fliF, fliJ, fliL, fliM, fliN, fliO, flip, fliQ, fliR, fliG, fliH, fliI, fliT, fliD, fliC, fljB, ycrG, flgN, flgM, flgA, flgB, flgC, flgD, flgE, flgF, flgG, flgH, flgI, flgJ, flgK, or flgL is regulated by an inducible promoter, and the bacterial cell is an exogenous flhDC , A composition comprising an exogenous inducible promoter operably linked to a gene of motA, motB, flhE, cheZ, cheY, cheB, cheR, cheM, cheW, cheA, fliA, fliY, fliZ, fliB, fliS, fliE, fliF, fliJ, fliL, fliM, fliN, fliO, flip, fliQ, fliR, fliG, fliH, fliI, fliT, fliD, fliC, fljB, ycrG, flgN, flgM, flgA, flgB, flgC, flgD, flgE, flgF, flgG, flgH, flgI, flgJ, flgK, or flgL. Claim 22 A composition according to claim 20, wherein the expression of flhDC, motA, motB, flhE, cheZ, cheY, cheB, cheR, cheM, cheW, cheA, fliA, fliY, fliZ, fliB, fliS, fliE, fliF, fliJ, fliL, fliM, fliN, fliO, flip, fliQ, fliR, fliG, fliH, fliI, fliT, fliD, fliC, fljB, ycrG, flgN, flgM, flgA, flgB, flgC, flgD, flgE, flgF, flgG, flgH, flgI, flgJ, flgK, or flgL is induced after the tumor, intratumoral cells, cancer, or metastasis is colonized by the bacteria. Claim 23 delete Claim 24 delete Claim 25 delete Claim 26 delete

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