Valve prosthesis

Abstract

The present invention relates to a valve prosthesis, comprising a stent and leaflets. The leaflets are disposed inside the stent, and the stent comprises a plurality of stent rods, the stent rods defining a mesh structure; the mesh structure at an end portion of the stent comprises a first mesh opening and a second mesh opening which are disposed in the circumferential direction, a connecting member being disposed at a first end of the first mesh opening, and the connecting member being used for connecting to a delivery device; thus, the valve prosthesis is not prone to deformation after being released.

Description

Valve prosthesis Technical Field

[0001] The present invention relates to the technical field of interventional medical equipment, and in particular to a valve prosthesis. Background Art

[0002] Heart valves are damaged by various pathogenic factors or are born with malformations, leading to abnormalities in the anatomical structure and function of one or more valves, manifesting as valvular stenosis and / or regurgitation. These conditions primarily affect the mitral and aortic valves (tricuspid and pulmonary valves are less commonly affected), manifesting as mitral stenosis (MS), mitral regurgitation (MR), aortic stenosis (AS), aortic regurgitation (AR), and combined valvular disease.

[0003] Currently, surgical valve replacements tend to be performed minimally invasively with small incisions to minimize patient injury and expedite recovery. This is particularly true when existing valve calcification cannot be removed and the anatomical location is poorly visualized, making valve suturing difficult with traditional surgical methods. Furthermore, if intraoperative examination reveals paravalvular leakage or other issues necessitating further replacement, the existing sutures must be carefully removed, increasing the surgical time and, since the valve annulus has already been damaged by sutures and knots, the incidence of complications after resuturing.

[0004] In recent years, transcatheter valve implantation has been increasingly used in the treatment of valvular disease. However, the valve is prone to deformation when released from the delivery device to the target position, which can easily lead to paravalvular leakage.

[0005] Summary of the Invention

[0006] The present invention aims to provide at least one valve prosthesis that is not easily deformed after release.

[0007] This purpose is achieved through the following technical solutions:

[0008] According to the technical solution of the first aspect of the present invention, a valve prosthesis is proposed, including a stent and a leaflet, the leaflet is arranged inside the stent, the stent includes a plurality of stent rods, the stent rods form a mesh structure, the mesh structure at the end of the stent includes a first mesh and a second mesh arranged circumferentially, the first mesh includes a first stent rod, a first arc and a second stent rod, a first angle is formed between the first stent rod and the second stent, the end of the first stent rod and the end of the second stent rod are connected to each other through the first arc, the first stent rod, the first arc and the second stent rod form the first end of the first mesh; the second mesh It includes a third support rod, a second arc and a fourth support rod, and there is a second angle between the third support rod and the fourth support rod, the end of the third support rod and the end of the fourth support rod are connected to each other through the second arc, and the third support rod, the second arc and the fourth support rod form the first end of the second mesh, wherein the first end of the first mesh and the first end of the second mesh are both located at the end of the support, the first angle is smaller than the second angle, the circumferential length between the two ends of the first arc is smaller than the circumferential length between the two ends of the second arc, and the first end of the first mesh is provided with a connecting piece, and the connecting piece is used to connect a conveyor.

[0009] The above-mentioned valve prosthesis includes a first mesh and a second mesh arranged circumferentially through a mesh structure arranged at the end of the stent of the valve prosthesis, the first mesh including a first stent rod, a first arc and a second stent rod, a first angle being formed between the first stent rod and the second stent rod, an end of the first stent rod and an end of the second stent rod are connected to each other through the first arc, and the first stent rod, the first arc and the second stent rod form the first end of the first mesh; the second mesh includes a third stent rod, a second arc and a fourth stent rod, a second angle being formed between the third stent rod and the fourth stent rod, an end of the third stent rod and an end of the fourth stent rod are connected to each other through the second arc, and the third stent rod, the second arc and the fourth stent rod form the first end of the second mesh, which In the embodiment, the first end of the first mesh and the first end of the second mesh are both located at the end of the stent, the first angle is smaller than the second angle, and the circumferential length between the two ends of the first arc is smaller than the circumferential length between the two ends of the second arc. Therefore, the first end of the first mesh is subjected to more concentrated force than the first end of the second mesh, and the first end of the first mesh is less likely to be circumferentially deformed than the first end of the second mesh. At this time, a connector is provided at the first end of the first mesh, and the connector is used to connect to the conveyor, so that the connector connected to the first mesh is not likely to move circumferentially when connected to the conveyor or released from the conveyor, so that the connector is guaranteed to move only in the radial direction as much as possible, thereby ensuring that the valve prosthesis is not prone to unnecessary deformation, thereby reducing the occurrence of paravalvular leakage.

[0010] Furthermore, the first arc line and the second arc line are circular arcs protruding outward from the end portion of the bracket.

[0011] Furthermore, the bracket includes a first bracket segment and a second bracket segment axially connected to each other, the bracket has an inflow end and an outflow end arranged opposite to each other, the first bracket segment is close to the outflow end, the second bracket segment is close to the inflow end, the end of the first bracket segment is provided with the first mesh and the second mesh, and the distance between the first bracket segment and the central axis of the bracket first increases and then decreases from the inflow end to the outflow end.

[0012] Furthermore, the plurality of mesh structures are connected by nodes, the first bracket segment has a plurality of first positions, the first position is the position where the distance between the first bracket segment and the central axial direction of the bracket is the largest, and the first position is provided with the node.

[0013] Furthermore, the first stent segment is a layer of the mesh structure, and the layer of the mesh structure is composed of the first meshes and the second meshes arranged circumferentially.

[0014] Furthermore, the first end of the first mesh is flush with the first end of the second mesh.

[0015] Furthermore, the plurality of first positions are located on the same circumference of the first stent segment.

[0016] Furthermore, the second bracket segment includes a multi-layer mesh structure, and the mesh structure of the second bracket segment includes a third mesh. A plurality of the third meshes are circumferentially arranged to form a layer of the mesh structure. The multi-layer mesh structures are axially connected, wherein the number of the third meshes in each layer of the mesh structure is the same, and in two adjacent layers of the mesh structure, the two axially adjacent third meshes are connected to each other.

[0017] Furthermore, the second support segment comprises a straight cylindrical type, and the circumferential lengths of the plurality of third meshes located on different layers are all the same. In the multi-layer mesh structure, the axial length of the third mesh located at or near the inflow end is longer than the axial length of the third mesh located at other layers, and the third mesh located at or near the inflow end comprises a fifth support rod, and the rod width of the fifth support rod is larger than the rod width of the support rod of the third mesh located at other layers.

[0018] Furthermore, the area connected to the connecting member is a connecting member support area, and the connecting member support area includes the first mesh and multiple supporting meshes, and multiple supporting meshes are arranged below the first mesh. The supporting mesh shares a part of the support rod with the first mesh, and the amount of support rods per unit area of ​​the connecting member support area is greater than the amount of support rods per unit area of ​​the second mesh.

[0019] Furthermore, the valve prosthesis also includes a skirt, which is arranged on the bracket. The skirt includes an inner skirt and an outer skirt that are connected to each other. The inner skirt fits the inner surface of the bracket, and the edge of the outer skirt is provided with an opening. After the outer skirt is turned outward, the opening is sutured to make the outer skirt fit the outer surface of the bracket.

[0020] Furthermore, the valve prosthesis also includes a skirt, which is arranged on the bracket, and the skirt includes an inner skirt and an outer skirt that are connected to each other, the inner skirt fits the inner surface of the bracket, and the outer skirt at least completely covers the inflow end or the third mesh near the inflow end. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Various other advantages and benefits will become apparent to those skilled in the art upon reading the detailed description of the preferred embodiment below. The accompanying drawings are for illustration purposes only and are not to be considered as limiting the present invention. The same reference numerals are used throughout the accompanying drawings to denote the same components. In the accompanying drawings:

[0022] FIG1 is a partial schematic diagram of a valve prosthesis provided in one embodiment.

[0023] FIG2 is a schematic diagram of a bracket provided by an embodiment.

[0024] FIG3 is a partial schematic diagram of a bracket provided in one embodiment.

[0025] FIG4 is an enlarged schematic diagram of portion C in FIG3 .

[0026] FIG5 is an enlarged schematic diagram of portion D in FIG1 .

[0027] FIG6 is a schematic diagram of a valve prosthesis provided by an embodiment being placed in the body.

[0028] FIG. 7 is a schematic diagram of the unfolding of the skirt provided in one embodiment. DETAILED DESCRIPTION

[0029] Exemplary embodiments of the present disclosure will be described in more detail below with reference to the accompanying drawings. Although exemplary embodiments of the present disclosure are shown in the accompanying drawings, it should be understood that the present disclosure can be implemented in various forms and should not be limited by the embodiments described herein. Rather, these embodiments are provided to enable a more thorough understanding of the present disclosure and to fully convey the scope of the present disclosure to those skilled in the art.

[0030] It should be understood that the terms used herein are for the purpose of describing specific example embodiments only and are not intended to be limiting. Unless the context clearly indicates otherwise, the singular forms "one", "an" and "said" as used herein may also be meant to include plural forms. The terms "comprise", "include", "contain" and "have" are inclusive and therefore specify the presence of stated features, steps, operations, elements and / or parts, but do not exclude the presence or addition of one or more other features, steps, operations, elements, parts, and / or combinations thereof. The method steps, processes, and operations described herein are not to be construed as necessarily requiring them to be performed in the specific order described or illustrated, unless the order of execution is clearly indicated. It should also be understood that additional or alternative steps may be used.

[0031] Although the terms first, second, third, etc. can be used in the text to describe multiple elements, components, regions, layers and / or sections, these elements, components, regions, layers and / or sections should not be limited by these terms. These terms can only be used to distinguish an element, component, region, layer or section from another region, layer or section. Unless the context clearly indicates otherwise, terms such as "first", "second" and other numerical terms do not imply order or sequence when used in the text. Therefore, the first element, component, region, layer or section discussed below can be referred to as the second element, component, region, layer or section without departing from the teaching of the example embodiments.

[0032] For ease of description, spatially relative terms may be used herein to describe the relationship of one element or feature relative to another element or feature as shown in the figures, such as "inside," "outside," "inside," "outside," "below," "beneath," "above," and the like. Such spatially relative terms are intended to include different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if the device in the figures is flipped, an element described as "below" or "below" another element or feature would then be oriented as "above" or "above" another element or feature. Thus, the example term "below" can include both above and below orientations. The device may be otherwise oriented (rotated 90 degrees or in other orientations) and the spatially relative descriptors used herein are interpreted accordingly.

[0033] It should be noted that the terms "distal" and "proximal" are commonly used in the field of interventional medical devices. "Distal" refers to the end away from the heart during surgery, while "proximal" refers to the end closer to the heart. Axial refers to the direction parallel to the line connecting the distal and proximal centers of the medical device; radial refers to the direction perpendicular to the axial direction; and circumferential refers to the direction around the outer surface of the medical device.

[0034] Referring to Figure 1, this embodiment provides a valve prosthesis 100, which includes a stent 1, leaflets 2 and a skirt 3. The leaflets 2 are arranged inside the stent 1. The stent 1 includes a plurality of stent rods 11, which form a mesh structure 12. The mesh structure 12 at the end of the stent 1 includes a first mesh 101 and a second mesh 102 arranged circumferentially.

[0035] 1 , 3 , 4 and 5 , the first mesh 101 includes a first support rod 1012, a first arc 1013 and a second support rod 1014, a first angle a1 being formed between the first support rod 1012 and the second support rod 1014, an end of the first support rod 1012 and an end of the second support rod 1014 being connected to each other through the first arc 1013, and the first support rod 1012, the first arc 1013 and the second support rod 1014 forming a first end 1011 of the first mesh; the second mesh 102 includes a third support rod 1023, a second arc 1025 and a fourth support rod 1024, a second angle a2 being formed between the third support rod 1023 and the fourth support rod 1024, The end of the third support rod 1023 and the end of the fourth support rod 1024 are connected to each other via a second arc 1025. The third support rod 1023, the second arc 1025, and the fourth support rod 1024 form the first end 1020 of the second mesh. The first end 1011 of the first mesh and the first end 1020 of the second mesh are both located at the end of the support 1. The first angle a1 is smaller than the second angle a2. The circumferential length b1 between the ends of the first arc 1013 is smaller than the circumferential length b2 between the ends of the second arc 1024. The first end of the first mesh 101 is provided with a connector 13 for connecting to a conveyor.

[0036] Among them, the first angle a1 is set to be smaller than the second angle a2, and the circumferential length b1 between the two ends of the first arc 1013 is smaller than the circumferential length between the two ends of the second arc. Therefore, the first end 1011 of the first mesh is subjected to more concentrated force than the first end 1020 of the second mesh, and the first end 1011 of the first mesh is less likely to be circumferentially deformed than the first end 1020 of the second mesh. At this time, a connector 13 is provided at the first end of the first mesh 101, and the connector 13 is used to connect the conveyor, so that the connector 13 connected to the first mesh 101 is not prone to circumferential movement when connected to the conveyor or released from the conveyor, so that the connector 13 is guaranteed to move only in the radial direction as much as possible, thereby ensuring that the valve prosthesis 100 is not prone to unnecessary deformation, thereby reducing the occurrence of paravalvular leakage.

[0037] In this embodiment, the first arc 1013 and the second arc 1025 are arcs that bulge outward from the end of the bracket 1, which can be more smoothly received into the conveyor while not easily scratching the inside of the conveyor. In other embodiments, the first arc 1013 and the second arc 1025 can also be arcs that bulge inward from the bracket 1.

[0038] 2 and 3 , in this embodiment, the maximum circumferential length of the first mesh 101 is smaller than the maximum circumferential length of the second mesh 102 ; or / and, the maximum axial length of the first mesh 101 is smaller than the maximum axial length of the second mesh 102 .

[0039] In this embodiment, with reference to FIG1 , the area connected to the connector 13 is a connector support area P. The connector support area P includes a first mesh 101 and a plurality of support meshes 104. Multiple support meshes 104 are provided on a side of the first mesh 101 away from the connector 13. The support meshes 104 and the first mesh 101 may share a portion of stent rods. The amount of stent rods per unit area of ​​the connector support area P is greater than the amount of stent rods per unit area of ​​the second mesh 102, so that the radial support force of the connector support area P is greater than the radial support force of the second mesh 102. The amount of stent rods herein can be the sum of the lengths of the stent rods, the sum of the volumes of the stent rods, or the sum of the number of stent rods, as long as the radial support force of the connector support area P is greater than the radial support force of the second mesh 102.

[0040] This embodiment, by providing a connector support region P comprising a first mesh 101 and a plurality of support meshes 104, can prevent the connector 13 connected to the first mesh 101 from circumferential movement when connected to or released from a conveyor. In other words, the connector 13 in FIG1 is less likely to wobble side to side, thereby preventing unnecessary deformation of the valve prosthesis 100 and reducing paravalvular leakage caused by poorly positioned release of the valve prosthesis 100. Furthermore, the second mesh 102 has fewer stent struts per unit area, giving the second mesh 102 greater freedom of movement and making it less susceptible to the forces of the first mesh 101. Specifically, in the process from non-release to semi-release, the connector 13 is still connected to the conveyor, the first mesh 101 connected to the connector 13 has not been fully released, and the second mesh 102 has basically been released. When it is in the process from semi-release to full release, the connector 13 is released from the conveyor, causing the first mesh 101 connected to the connector 13 to produce a radially outward spring action, which easily drives the second mesh 102 circumferentially connected to the first mesh 101 to also produce a corresponding force, thereby causing the stent as a whole to bounce, resulting in unexpected displacement of the valve prosthesis. At this time, the amount of stent rods per unit area of ​​the second mesh 102 is relatively small, which can make the second mesh 102 have a greater degree of freedom and is not easily affected by the force of the first mesh 101. It can greatly reduce the unexpected displacement of the valve prosthesis and improve the release stability of the valve prosthesis.

[0041] Among them, the stent 1 has an inflow end A and an outflow end B that are relatively set. The end of the stent 1 can refer to the inflow end A. At this time, the surgical procedure adopted is transapical release of the valve prosthesis. The end of the stent 1 can also refer to the inflow end B. At this time, the surgical procedure adopted is transaortic release of the valve prosthesis.

[0042] Referring to Figure 3, in this embodiment, the stent 1 includes a first stent segment L1 and a second stent segment L2 axially connected to each other, the first stent segment L1 is close to the outflow end B, and the second stent segment L2 is close to the inflow end A. The end of the first stent segment L1 is provided with a first mesh 101 and a second mesh 102, and the distance between the first stent segment L1 and the central axis O of the stent first increases and then decreases from the inflow end A to the outflow end B.

[0043] Specifically, in this embodiment, a portion 110 of the first stent segment L1 near the outflow end B extends toward the central axis O, facilitating the insertion of the valve prosthesis 100 into the delivery device. A portion 120 of the first stent segment L1 near the inflow end A also extends toward the central axis O before connecting to the second stent segment L2. The second stent segment L2 includes a concave section 130 near the outflow end B. This concave section 130 smoothly transitions to the portion 120 of the first stent segment L1 near the inflow end A, preventing coronary artery occlusion and preventing blood flow from being affected.

[0044] In this embodiment, multiple mesh structures are connected by nodes. The first stent segment L1 has multiple first locations 140. First locations 140 are the locations where the distance between the first stent segment L1 and the central axis O of the stent is greatest. Nodes 1401 are provided at these first locations. In other words, nodes 1401 are provided at the locations where the first stent segment L1 protrudes radially outward the furthest. This ensures that the radial support force is maximized at the locations where the stent 1 contacts and supports the tissue inner wall, preventing deformation of the stent 1 caused by interference from hard objects such as plaque, which could lead to paravalvular leakage. In this embodiment, multiple first locations 140 can be located on the same circumference of the first stent segment L1. In this case, multiple nodes 1401 are located on the same circumference of the first stent segment L1 to ensure central symmetry of the first stent segment L1, thereby enabling the stent 1 to be implanted in a more suitable and controlled manner. In other embodiments, multiple first locations 140 can be located on different circumferences of the first stent segment L1.

[0045] In this embodiment, the first stent segment L1 further comprises a single-layer mesh structure, comprising a circumferential arrangement of first mesh 101 and second mesh 102. In this case, the mesh structure of the first stent segment L1 is relatively large, resulting in a relatively low radial support force. The first stent segment L1 is relatively flexible overall, allowing it to better conform to the tissue inner wall. Furthermore, referring to Figures 3 and 6 , since the first stent segment L1 has only a single-layer mesh structure, the portion 120 of the first stent segment L1 near the inflow end A extends toward the central axis O. In other words, the portions of the first mesh 101 and the second mesh 102 near the inflow end A are recessed toward the central axis O, allowing the second mesh 102 to communicate with the coronary artery 200. Furthermore, since the second mesh 102 is sufficiently large, after implantation of the valve prosthesis 100, surgical procedures on the coronary artery 200 can be performed through the second mesh 102 without affecting the implanted valve prosthesis 100. In other embodiments, the first stent segment L1 may comprise a multi-layer mesh structure.

[0046] In FIG3 , the first end 1011 of the first mesh 101 connected to the connector is flush with the first end 1020 of the second mesh 102, that is, they are located on the same straight line N, to avoid problems that affect the assembly effect and efficiency and backflow. Under the premise of ensuring that the first position 140 is provided with a node 1401, if the first end 1020 of the second mesh 102 is lower than the first end 1011 of the first mesh 101 connected to the connector, the portion of the second mesh 102 near the outflow end B is shorter, that is, the portion 110 of the first stent segment L1 near the outflow end B is shorter, and the portion 110 of the first stent segment L1 near the outflow end B extends shorter in the direction of the central axis O, thereby shortening the guide section for the valve prosthesis 100 to be placed in the conveyor, making the valve prosthesis 100 less smooth when placed in the conveyor, affecting the assembly effect and efficiency. If the first end 1020 of the second mesh 102 is higher than The first mesh 101 is connected to the first end 1011 of the connector, and the length of the first stent segment L1 will become longer. However, under the premise that the length of the stent 1 remains unchanged, in order to ensure that the fixing effect of the valve prosthesis 100 is not affected and paravalvular leakage does not occur, the length of the inflow channel M of the stent 1 (referring to the distance between the lowest edge of the leaflet and the inflow end A of the stent) cannot be reduced. Since the leaflet angle 21 is already at the top, the axial length of the leaflet 2 on the stent 1 will be shortened due to the increase in the length of the first stent segment L1, which will affect the degree of fit between the multiple leaflets, and then lead to incomplete closure between the leaflets, resulting in reflux.

[0047] Referring to FIG3 , the second stent segment L2 comprises a multi-layer mesh structure, including third meshes 103. Multiple third meshes 103 are circumferentially arranged to form a layer of mesh structures 201, 202, and 203. The multi-layer mesh structure is axially connected, with each layer 201, 202, and 203 having the same number of third meshes 103. In two adjacent layers, axially adjacent third meshes are interconnected. This design ensures more uniform axial force transmission within the second stent segment L2, thereby ensuring greater overall stability of the valve prosthesis 100 during both placement and release from the delivery device, making it less susceptible to deformation and displacement.

[0048] The second stent segment L2 is generally straight-cylindrical in shape, and includes a concave section 130 near the outflow end B. Compared to the second stent segment L2, which is generally tapered, the diameter of the second stent segment L2 gradually decreases from the inflow end A to the outflow end B. In vivo, due to the backflow of blood flow, this tapered shape can easily weaken the fixation of the valve prosthesis 100, making it easier for the valve prosthesis to slip into the heart.

[0049] Specifically, the circumferential lengths of the plurality of third meshes 103 located on different layers are all the same. In the multi-layer mesh structure, the axial lengths of the third meshes 103 located at or near the inflow end A are longer than the axial lengths of the third meshes 103 located at other layers. Furthermore, the axial lengths of the multi-layer mesh structure can gradually decrease from the inflow end A to the outflow end B. That is, the axial lengths of one layer of mesh structure 201, one layer of mesh structure 202, and one layer of mesh structure 203 gradually decrease from the inflow end A to the outflow end B. Furthermore, the third mesh located at or near the inflow end A (i.e., mesh structure 201) includes a fifth support rod 2011, and the rod width of the fifth support rod 2011 is greater than the rod widths of the support rods (e.g., the sixth support rod 2021 and the seventh support rod 2031) of the third meshes located at other layers (e.g., mesh structures 202 and 203). The mesh structure 202 includes a sixth stent rod 2021, and the mesh structure 203 includes a seventh stent rod 2031. This design allows the third mesh located at or near the inflow end A, that is, the mesh structure 201, to have a longer axial length, thereby ensuring a longer fit length with the valve annulus and preventing paravalvular leakage. At the same time, its rod width is also larger, thereby increasing its radial support force, which is used to better fix it at the valve annulus and improve the fixation performance of the entire valve prosthesis. Furthermore, the radial support force of the mesh structure 203 is greater than the radial support force of the mesh structure 202. For example, in this embodiment, the axial length of the mesh structure 203 is set to be smaller than the axial length of the mesh structure 202. The mesh structure 203 on the stent 1 is located close to the free ends of the native leaflets, thereby requiring a greater radial support force to open the free ends of the native leaflets, thereby achieving better fixation of the valve prosthesis.

[0050] In this embodiment, the second stent segment L2 has a three-layer mesh structure 201, 202, and 203. One end of some third meshes 103 in the third mesh structure 203 is connected to the second end 1010 of the first mesh 101, and the first end 1011 of the first mesh 101 is connected to the connector 13. In the third mesh structure 203, adjacent third meshes 103 extend from one end to form support rods 1021 and 1022, respectively. Support rods 1021 and 1022 extend from one end to form support rods 1024 and 1023, respectively. Support rods 1024 and 1023 converge at a point, forming the second mesh 102. In other embodiments, the second stent segment L2 may have a multi-layer mesh structure.

[0051] In this embodiment, the radial force exerted by the first stent segment L1 is less than that exerted by the second stent segment L2. The relatively low radial force exerted by the first stent segment L1 allows for better conformity to the tissue inner wall, adapting to various in vivo environments, and facilitating easier storage within the delivery device. The relatively high radial force exerted by the second stent segment L2 reduces the radial load of the attached leaflets, ensuring greater stability and preventing deformation.

[0052] Referring to FIG7 , valve prosthesis 100 further includes a skirt 3 , which is disposed on stent 1 and comprises an interconnected inner skirt 31 and an outer skirt 32 . The inner skirt 31 conforms to the inner surface of the stent 1 , while the edge 320 of the outer skirt 32 is provided with a plurality of openings 321 to facilitate eversion of the outer skirt 32 . After eversion, suturing the openings 321 allows the outer skirt 32 to conform more closely to the outer surface of the stent 1 . In this embodiment, the edge 320 of the outer skirt 32 is generally serrated to facilitate suturing to the stent rod and includes a plurality of trapezoidal grooves. The openings 321 are formed by the bottoms of the trapezoidal grooves being recessed toward the inner skirt 31 and are V-shaped. In other embodiments, the openings 321 may also be W-shaped, U-shaped, or similar, as long as they allow the outer skirt 32 to conform more closely to the outer surface of the stent 1 . In this embodiment, the outer skirt 32 at least completely covers the mesh structure 201. Since the mesh structure 201 is placed at the valve annulus, paravalvular leakage can be prevented from occurring at the valve annulus.

[0053] The above description is merely a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any changes or substitutions that can be easily conceived by a person skilled in the art within the technical scope disclosed in the present invention should be included in the scope of protection of the present invention. Therefore, the scope of protection of the present invention should be based on the scope of protection of the claims.

Claims

1. A valve prosthesis, comprising a stent and a leaflet, wherein the leaflet is arranged inside the stent, the stent comprises a plurality of stent rods, and the stent rods form a mesh structure, characterized in that: The mesh structure at the end of the stent includes a first mesh and a second mesh arranged circumferentially, The first mesh includes a first support rod, a first arc and a second support rod, a first angle is formed between the first support rod and the second support rod, an end of the first support rod and an end of the second support rod are connected to each other through the first arc, and the first support rod, the first arc and the second support rod form a first end of the first mesh; the second mesh includes a third support rod, a second arc and a fourth support rod, a second angle is formed between the third support rod and the fourth support rod, an end of the third support rod and an end of the fourth support rod are connected to each other through the second arc, and the third support rod, the second arc and the fourth support rod form a first end of the second mesh, Wherein, the first end of the first mesh and the first end of the second mesh are both located at the end of the bracket, the first angle is smaller than the second angle, the circumferential length between the two ends of the first arc is smaller than the circumferential length between the two ends of the second arc, and the first end of the first mesh is provided with a connecting piece, and the connecting piece is used to connect a conveyor.

2. The valve prosthesis according to claim 1, characterized in that: The first arc line and the second arc line are circular arcs protruding outward from the end of the bracket.

3. The valve prosthesis according to claim 1, characterized in that: The stent includes a first stent segment and a second stent segment axially connected to each other, the stent has an inflow end and an outflow end arranged opposite to each other, the first stent segment is close to the outflow end, the second stent segment is close to the inflow end, the first mesh and the second mesh are arranged at the end of the first stent segment, and the distance between the first stent segment and the central axis of the stent first increases and then decreases in the direction from the inflow end to the outflow end.

4. The valve prosthesis according to claim 3, characterized in that: The plurality of mesh structures are connected via nodes, the first bracket segment has a plurality of first positions, the first position being a position where the distance between the first bracket segment and the central axis of the bracket is the largest, and the first position is provided with the node.

5. The valve prosthesis according to claim 4, characterized in that: The first stent segment is a layer of the mesh structure, and the layer of the mesh structure is composed of the first meshes and the second meshes arranged circumferentially.

6. The valve prosthesis according to claim 5, characterized in that: The first end of the first mesh is flush with the first end of the second mesh.

7. The valve prosthesis according to claim 4, characterized in that: The plurality of first positions are located on the same circumference of the first stent segment.

8. The valve prosthesis according to claim 3, characterized in that: The second bracket segment includes a multi-layer mesh structure, and the mesh structure of the second bracket segment includes a third mesh. A plurality of the third meshes are circumferentially arranged to form a layer of the mesh structure. The multi-layer mesh structures are axially connected, wherein the number of the third meshes in each layer of the mesh structure is the same, and in two adjacent layers of the mesh structure, two axially adjacent third meshes are connected to each other.

9. The valve prosthesis according to claim 8, characterized in that: The second support segment comprises a straight cylinder type, and the circumferential lengths of the plurality of third meshes located on different layers are all the same; in the multi-layer mesh structure, the axial lengths of the third meshes located at or near the inflow end are longer than the axial lengths of the third meshes located at other layers, and the third meshes located at or near the inflow end comprise a fifth support rod, and the rod width of the fifth support rod is greater than the rod width of the support rods of the third meshes located at other layers.

10. The valve prosthesis according to claim 1, characterized in that: The area connected to the connecting member is a connecting member support area, and the connecting member support area includes the first mesh and multiple supporting meshes. Multiple supporting meshes are arranged on the side of the first mesh away from the connecting member, and the amount of support rods per unit area of ​​the connecting member support area is greater than the amount of support rods per unit area of ​​the second mesh.

11. The valve prosthesis according to claim 1, characterized in that: The valve prosthesis also includes a skirt, which is arranged on the bracket. The skirt includes an inner skirt and an outer skirt that are connected to each other. The inner skirt fits the inner surface of the bracket, and the edge of the outer skirt is provided with an opening. After the outer skirt is turned outward, the opening is sutured to make the outer skirt fit the outer surface of the bracket.

12. The valve prosthesis according to claim 9, characterized in that: The valve prosthesis also includes a skirt, which is arranged on the bracket, and includes an inner skirt and an outer skirt connected to each other, the inner skirt fits the inner surface of the bracket, and the outer skirt at least completely covers the inflow end or the third mesh near the inflow end.

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