Salicylic acid solubilizing composition

Abstract

According to an embodiment of the present application, the provided salicylic acid solubilizing composition comprises salicylic acid, a solubilizing agent and a polyol. The solubilizing agent can include octyldodeceth-16 and C12-14 pareth-12, and the polyol can be included in the amount of 20-90 wt% on the basis of the total weight of the composition.

Description

Salicylic acid solubilizing composition

[0001] The present application relates to a salicylic acid solubilizing composition.

[0002] Keratinocytes, which are produced in the basal layer of the skin, migrate through the spinous layer, granular layer, and stratum corneum in that order as new keratinocytes are produced. Keratinocytes have a lifespan of approximately two weeks, and dead keratinocytes remain in the stratum corneum for approximately two weeks before being shed from the skin. Accordingly, the skin regeneration cycle is known to be approximately 28 days.

[0003] However, the skin regeneration cycle can be lengthened or shortened for various reasons, including UV exposure, stress, lack of sleep, dehydration, and nutritional imbalances. Specifically, when the skin regeneration cycle is prolonged, the stratum corneum thickens, causing rough skin, reduced absorption and spreadability of cosmetics, and dead skin cells can clog pores, leading to acne.

[0004] Meanwhile, salicylic acid removes dead skin cells and impurities from the skin surface and pores, and its anti-inflammatory and antibacterial properties improve acne and soothe the skin. Therefore, it is used as a key ingredient in exfoliants. However, salicylic acid is a typical poorly soluble ingredient due to its fat solubility, and research is ongoing into surfactants and solubilizers to stabilize it.

[0005] In particular, when the content of salicylic acid is insufficient, there is a problem that the effects of improving keratin and acne are low. Accordingly, an effective solubilizer that can solubilize sufficient content of salicylic acid is needed.

[0006] The purpose of this application is to provide a salicylic acid solubilizing composition for solving the above problems.

[0007] The technical problems of the present application are not limited to the technical problems mentioned above, and other technical problems not mentioned will be clearly understood by those skilled in the art from the description below.

[0008] According to an embodiment of the present application, a salicylic acid solubilizing composition is provided. The salicylic acid solubilizing composition comprises salicylic acid, a solubilizing agent, and a polyol, wherein the solubilizing agent comprises octyldodeceth-16 and C12-14pareth-12, and the polyol may be included in an amount of 20 to 90 wt% based on the total weight of the composition.

[0009] Additionally, the salicylic acid may be included in an amount of 1 to 6 wt% based on the total weight of the composition.

[0010] Additionally, the C12-14pareth-12 may be included in a weight ratio of 0.1 to 10 based on the weight of octyldodeceth-16.

[0011] Additionally, the octyldodeceth-16 may be included in an amount of more than 0.5 wt% and less than 1.5 wt% based on the total weight of the composition.

[0012] Additionally, the C12-14pareth-12 may be included in an amount of 0.01 to 10 wt% based on the total weight of the composition.

[0013] In addition, the polyol may include at least one selected from the group consisting of propylene glycol, dipropylene glycol, methylpropanediol, butylene glycol, pentylene glycol, isopentyldiol, hexylene glycol, caprylyl glycol, glycerin, and diglycerin.

[0014] Additionally, the solubilizer and the polyol may be included in a weight ratio of 1 to 10:20 to 90.

[0015] Additionally, the octyldodeceth-16, the C12-14pareth-12, and the polyol may be included in a weight ratio of 1:0.1 to 10:20 to 90.

[0016] Additionally, according to an embodiment of the present application, a cosmetic composition may be provided. The cosmetic composition may include a salicylic acid solubilizing composition according to an embodiment of the present application.

[0017] Additionally, the cosmetic composition may be used for exfoliation.

[0018] According to an embodiment of the present application, a formulation including salicylic acid, a poorly soluble component, can be stably maintained by controlling the weight ratio of the solubilizer and polyol.

[0019] In addition, according to the embodiment of the present application, the effect of improving keratin can be maximized by stabilizing salicylic acid.

[0020] To facilitate a more thorough understanding of the drawings cited in the detailed description of this application, a brief description of each drawing is provided.

[0021] Figures 1 to 4 are photographs showing the appearance of a salicylic acid solubilizing composition.

[0022] The structural or functional descriptions of the embodiments disclosed in this specification are merely illustrative for the purpose of explaining embodiments according to the technical concept of the present application. Furthermore, embodiments according to the technical concept of the present application may be implemented in various forms other than those disclosed herein. Furthermore, the technical concept of the present application is not limited to the embodiments described herein.

[0023] Among the properties mentioned in this specification, if the measurement temperature affects the properties, the properties are properties measured at room temperature and pressure unless otherwise specified.

[0024] The term room temperature used in this specification refers to the natural temperature that is not heated or cooled, and may mean, for example, any temperature within the range of 10°C to 30°C, for example, a temperature that is about 15°C or higher, about 18°C ​​or higher, about 20°C or higher, about 23°C or higher, about 27°C or lower, or 25°C. Unless specifically defined herein, the unit of temperature is Celsius (°C).

[0025] The terms a to b used in this specification mean a and b inclusive and within the range between a and b.

[0026] The terminology used in this specification is for the purpose of describing embodiments and is not intended to limit and / or restrict the present application. The singular expression includes the plural expression unless the context clearly indicates otherwise. In this specification, it should be understood that the terms "comprises" or "has" are intended to indicate the presence of a feature, number, step, operation, component, part, or combination thereof described in the specification, but do not preclude the possibility of the presence or addition of one or more other features, numbers, steps, operations, components, parts, or combinations thereof.

[0027]

[0028] In this specification, “solubilization” refers to a phenomenon in which the solubility of salicylic acid, a poorly soluble component, increases and it remains in a thermodynamically stable state.

[0029] In this specification, “solubilizing agent” refers to an ingredient that increases the solubility of salicylic acid, a poorly soluble ingredient.

[0030]

[0031] According to an embodiment of the present application, a salicylic acid solubilizing composition is provided. The salicylic acid solubilizing composition may include salicylic acid, a solubilizing agent, and a polyol.

[0032] Salicylic acid is a fat-soluble beta-hydroxy acid (BHA) ingredient that helps improve skin keratin and acne. However, salicylic acid is an acidic ingredient, and excessive amounts can cause skin tissue destruction due to strong irritation.

[0033] Salicylic acid may be present in an amount of at least 1 wt%, at least 1.5 wt%, or at least 2 wt%, or at most 6 wt%, at most 5 wt%, at most 4 wt%, at most 3 wt%, at most 2.5 wt%, or at most 2 wt%, based on the total weight of the composition. For example, the salicylic acid solubilizing composition may comprise 1 to 6 wt%, or 2 to 6 wt%, of salicylic acid.

[0034] When the salicylic acid solubilizing composition includes salicylic acid within the aforementioned range, salicylic acid can be stably solubilized within the solubilizing composition, and not only can the cosmetic composition including the salicylic acid solubilizing composition sufficiently exhibit effects such as improvement of keratin and improvement of acne, but also has the advantage of low risk of skin irritation.

[0035] The solubilizer is used to stabilize or solubilize salicylic acid, which is a poorly soluble component, and may include Octyldodeceth-16 and C12-14Pareth-12. The salicylic acid solubilizing composition may require sufficient solubilizer and polyol, for example, since it contains 1 to 6 wt% of salicylic acid. If the content of the solubilizer and polyol is insufficient, it may be difficult to stabilize or solubilize a high content of salicylic acid, and since salicylic acid is not stabilized in the composition, there may be concerns about skin irritation.

[0036] In embodiments, octyldodeceth-16 can be present in an amount greater than 0.5 wt%, greater than 0.6 wt%, greater than 0.7 wt%, greater than 0.8 wt%, greater than 0.9 wt%, or greater than 1 wt%, or less than 1.5 wt%, less than 1.4 wt%, less than 1.3 wt%, less than 1.2 wt%, less than 1.1 wt%, or less than 1 wt%, based on the total weight of the composition. For example, the salicylic acid solubilizing composition can comprise octyldodeceth-16 in an amount greater than 0.5 wt% and less than 1.5 wt%, from 0.6 to 1.4 wt%, or from 0.8 to 1.2 wt%.

[0037] In embodiments, C12-14pareth-12 may be present in an amount of at least 0.01 wt%, at least 0.05 wt%, at least 0.1 wt%, at least 0.5 wt%, at least 1 wt%, at least 2 wt%, at least 3 wt%, or at least 4 wt%, or at most 10 wt%, at most 9 wt%, at most 8 wt%, at most 7 wt%, at most 6 wt%, at most 5 wt%, at most 4 wt%, at most 3 wt%, or at most 2 wt%, based on the total weight of the composition. For example, the salicylic acid solubilizing composition may comprise C12-14pareth-12 in an amount of 0.01 to 10 wt%, or 0.1 to 4 wt%.

[0038] In an embodiment, C12-14pareth-12 can be present in an amount of 0.1 wt% or more, 0.5 wt% or more, 1 wt% or more, 2 wt% or more, 3 wt% or more, or 4 wt% or less, 10 wt% or less, 9 wt% or less, 8 wt% or less, 7 wt% or less, 6 wt% or less, 5 wt% or less, 4 wt% or less, 3 wt% or less, or 2 wt% or less, relative to the weight of octyldodeceth-16. For example, the solubilizer can comprise C12-14pareth-12 in an amount of 0.1 to 10 wt%, 0.1 to 8 wt%, or 0.1 to 4 wt% relative to the weight of octyldodeceth-16.

[0039] Polyol refers to an aliphatic compound having two or more hydroxyl groups (-OH). In an embodiment, the polyol may include at least one selected from the group consisting of propylene glycol, dipropylene glycol, methylpropanediol, butylene glycol, pentylene glycol, isopentyldiol, hexylene glycol, caprylyl glycol, glycerin, and diglycerin.

[0040] In embodiments, the polyol may be present in an amount of at least 20 wt%, at least 25 wt%, at least 30 wt%, or at least 35 wt%, or at most 90 wt%, at most 80 wt%, at most 70 wt%, at most 60 wt%, at most 50 wt%, at most 45 wt%, at most 40 wt%, at most 35 wt%, or at most 30 wt%, based on the total weight of the composition. For example, the salicylic acid solubilizing composition may comprise 20 to 90 wt%, 20 to 60 wt%, or 20 to 35 wt% of the polyol.

[0041] In embodiments, the polyol may be present in an amount of at least 20 parts by weight, at least 25 parts by weight, at least 30 parts by weight, or at least 35 parts by weight, or at most 90 parts by weight, at most 80 parts by weight, at most 70 parts by weight, at most 60 parts by weight, at most 50 parts by weight, at most 45 parts by weight, at most 40 parts by weight, at most 35 parts by weight, or at most 30 parts by weight relative to 1 to 10 parts by weight of the solubilizer. For example, the polyol may be present in an amount of from 20 to 90 parts by weight, from 20 to 60 parts by weight, from 20 to 45 parts by weight, or from 20 to 35 parts by weight relative to 1 to 10 parts by weight of the solubilizer.

[0042] In an embodiment, the salicylic acid solubilizing composition may comprise octyldodeceth-16, C12-14pareth-12, and a polyol in a weight ratio of 1:0.1 to 10:20 to 90, respectively. Specifically, the salicylic acid solubilizing composition may comprise octyldodeceth-16, C12-14pareth-12, and a polyol in a weight ratio of 1:0.1 to 10:20 to 60, a weight ratio of 1:0.1 to 10:20 to 45, or a weight ratio of 1:0.1 to 10:20 to 35.

[0043] Meanwhile, a capryloyl salicylic acid solubilizing composition was prepared using the same solubilizing agent and polyol as in the examples of the present application, but when capryloyl salicylic acid was included, the composition became cloudy and a layer separation phenomenon occurred, resulting in an unstable formulation, and the keratin improvement effect was also lower than that of salicylic acid. In other words, the solubilizing agent and polyol according to the examples of the present application were suitable for solubilizing salicylic acid, but were not suitable for solubilizing capryloyl salicylic acid.

[0044]

[0045] According to an embodiment of the present application, a cosmetic composition comprising a salicylic acid solubilizing composition is provided. The cosmetic composition can be manufactured into various products. For example, it can be manufactured into functional cosmetics such as nourishing creams, essences, and ampoules, or basic cosmetics such as toners and lotions. In addition, it can be manufactured into soaps, detergents, cleansing creams, and cleansing waters, or color cosmetics such as lipsticks, lip balms, mascara, blushers, shading, highlighters, makeup bases, foundations, pacts, concealers, and skin covers. It can also be manufactured into hair cleansing products such as shampoos, rinses, hair conditioners, and hair gels. Furthermore, it can be manufactured into products that adhere to the skin, such as packs, hydrogel slimming patches, or products that are sprayed onto the skin, such as mists and aerosols.

[0046] In an embodiment, the cosmetic composition may further include additives commonly used in the art, as long as they do not impair the effects of the present application. For example, the cosmetic composition may further include thickeners, pH adjusters, surfactants, stabilizers, preservatives, antiseptics, bactericides, moisturizers, sunscreens, skin conditioning agents, whitening agents, colorants, organic pigments, inorganic pigments, fragrances, vitamins, natural pigments, pearls, and other functional ingredients. Here, the functional ingredients may include, for example, wrinkle-improving ingredients, whitening ingredients, antioxidant ingredients, anti-aging ingredients, plumping ingredients, exfoliating ingredients, scrubbing ingredients, moisturizing ingredients, skin barrier strengthening ingredients, skin elasticity strengthening ingredients, and the like. Those skilled in the art can easily select the blending amounts of the above ingredients, as long as they do not impair the purpose and effects of the present application.

[0047] In an embodiment, the cosmetic composition may be for exfoliation. Such an exfoliation cosmetic composition may include, in addition to the aforementioned ingredients, commonly used ingredients, such as moisturizers, preservatives, thickeners, surfactants, fragrances, etc., and these ingredients can be easily selected by those skilled in the art within a range that does not impair the purpose and effect of the present application.

[0048]

[0049] Hereinafter, the present application will be described in more detail through manufacturing examples and experimental examples. However, these manufacturing examples or experimental examples are intended to illustrate some experimental methods and compositions for illustrative purposes, and the scope of the present application is not limited to these manufacturing examples or experimental examples.

[0050]

[0051] Manufacturing example

[0052]

[0053] (1) Manufacturing example: Manufacturing of salicylic acid solubilizing composition

[0054]

[0055] Each component was mixed in a weight ratio according to Tables 1 to 4 below and stirred sufficiently to prepare a salicylic acid solubilizing composition.

[0056]

[0057] Classification Manufacturing Example 1 Manufacturing Example 2 Manufacturing Example 3 Manufacturing Example 4 Manufacturing Example 5 Comparative Manufacturing Example 1 Comparative Manufacturing Example 2 Comparative Manufacturing Example 3 Salicylic Acid 2 2 2 2 2 2 2 Solubilizer Octyldodeceth-16 1 1 1 1 1-1 C 1 2 - 1 4 Pareth-12 0.10.5 1 2 3 - 0.1 1 Polyol Dipropylene Glycol 2 2 0 ...

[0058]

[0059] Classification Manufacturing Example 6 Manufacturing Example 7 Manufacturing Example 8 Manufacturing Example 9 Manufacturing Example 10 Manufacturing Example 11 Comparative Manufacturing Example 4 Comparative Manufacturing Example 5 Comparative Manufacturing Example 6 Comparative Manufacturing Example 7 Salicylic acid 2222222222 Solubilizer Octyldodeceth-16 1111111110.5 1.5 C12-14 Pareth-12 0.10.5 1234-0.05 11 Polyol Dipropylene Glycol 25 25 25 25 25 25 25 25 25 25 Purified water to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100

[0060]

[0061] Classification Manufacturing Example 12 Manufacturing Example 13 Manufacturing Example 14 Manufacturing Example 15 Salicylic acid 2222 Solubilizer Octyldodeceth-16 1111 C12-14 Pareth-12 0.10.5 11 Polyol Dipropylene glycol 30 30 30 35 Purified water to 100 to 100 to 100 to 100

[0062]

[0063] Comparative Manufacturing Example 8 Comparative Manufacturing Example 9 Capryloyl Salicylic Acid 22 Solubilizer Octyldodeceth-16 11 C12-14 Pareth-12 0.13 Polyol Dipropylene Glycol 25 25 Purified Water to 100 to 100

[0064] The specific manufacturing method is as follows.

[0065] Salicylic acid or capryloyl salicylic acid was mixed with a solubilizer and stirred, then polyol was added and stirred to prepare a salicylic acid solubilizing composition. The solubilizing phase was then added to the water phase and stirred thoroughly before being used in the following experiments.

[0066]

[0067] Experimental example

[0068]

[0069] (1) Experimental Example 1: Confirmation of Formulation Stability of Salicylic Acid Solubilizing Composition

[0070]

[0071] The formulation stability of the salicylic acid solubilizing composition prepared above was confirmed and is described in Tables 5 to 8 below.

[0072] Formulation stability was evaluated by visually observing the appearance of the salicylic acid solubilized composition after leaving it at room temperature (23±2℃) for approximately 4 weeks and assessing the presence or absence of layer separation or precipitation and the degree of transparency.

[0073]

[0074] Classification Formulation Stability Manufacturing Example 1 Stability Manufacturing Example 2 Stability Manufacturing Example 3 Stability Manufacturing Example 4 Stability Manufacturing Example 5 Stability Comparative Manufacturing Example 1 Unstable Comparative Manufacturing Example 2 Unstable Comparative Manufacturing Example 3 Unstable

[0075] When containing 20 wt% of polyol, Preparation Examples 1 to 5 containing 1 wt% of octyldodeceth-16 and 0.1 to 3 wt% of C12-14pareth-12 maintained stable formulations.

[0076] On the other hand, Comparative Manufacturing Example 1 that did not include C12-14pareth-12 and Comparative Manufacturing Example 2 that did not include octyldodeceth-16 exhibited layer separation and precipitation, resulting in an unstable formulation.

[0077] Meanwhile, Comparative Manufacturing Example 3 containing 15 wt% of polyol was cloudy and the formulation was unstable.

[0078] As shown in Fig. 1, Manufacturing Examples 1 to 5 exhibited a transparent appearance, whereas Comparative Manufacturing Examples 1 to 3 exhibited layer separation and precipitation phenomena or a cloudy appearance.

[0079]

[0080] Stability Manufacturing Example 6 Stability Manufacturing Example 7 Stability Manufacturing Example 8 Stability Manufacturing Example 9 Stability Manufacturing Example 10 Stability Manufacturing Example 11 Stability Comparative Manufacturing Example 4 Unstable Comparative Manufacturing Example 5 Unstable Comparative Manufacturing Example 6 Unstable Comparative Manufacturing Example 7 Unstable

[0081] When containing 25 wt% of polyol, Preparation Examples 6 to 11 containing 1 wt% of octyldodeceth-16 and 0.1 to 4 wt% of C12-14pareth-12 maintained stable formulations.

[0082] On the other hand, comparative manufacturing example 4, which did not include C12-14pareth-12, had an unstable formulation due to layer separation and precipitation.

[0083] Meanwhile, Comparative Manufacturing Example 5, which contains 1 wt% of octyldodeceth but 0.05 wt% of C12-14 pareth-12 (where the weight ratio of C12-14 pareth-12 to the weight of octyldodeceth is outside the range of 0.1 to 10), Comparative Manufacturing Example 6, which contains 0.5 wt% of octyldodeceth, and Comparative Manufacturing Example 7, which contains 1.5 wt% of octyldodeceth, were cloudy or showed layer separation, resulting in an unstable formulation.

[0084] As shown in Fig. 2, manufacturing examples 6 to 11 exhibited a transparent appearance, whereas comparative manufacturing examples 4 to 7 exhibited a layer separation phenomenon or a cloudy appearance.

[0085]

[0086] Stability of the formulation Example 12 Stability of the formulation Example 13 Stability of the formulation Example 14 Stability of the formulation Example 15 Stability

[0087] When containing 30 wt% of polyol, Preparation Examples 12 to 14 containing 1 wt% of octyldodeceth-16 and 0.1 to 1 wt% of C12-14pareth-12, and Preparation Example 15 containing 1 wt% of octyldodeceth-16 and 1 wt% of C12-14pareth-12 when containing 35 wt% of polyol, all maintained stable formulations.

[0088] As shown in Fig. 3, Manufacturing Examples 12 to 15 exhibited a transparent appearance.

[0089]

[0090] Comparison of stability of the formulation (manufacturing example 8) Comparison of instability (manufacturing example 9)

[0091] Meanwhile, Comparative Manufacturing Example 8, which contained the same solubilizer and polyol as Manufacturing Example 6 but capryloyl salicylic acid instead of salicylic acid, became cloudy and had an unstable formulation, and Comparative Manufacturing Example 9, which contained the same solubilizer and polyol as Manufacturing Example 10 but capryloyl salicylic acid instead of salicylic acid, became cloudy and a layer separation phenomenon occurred, resulting in an unstable formulation.

[0092] As shown in Fig. 4, comparative manufacturing examples 8 and 9 were observed to be cloudy or to exhibit layer separation.

[0093]

[0094] (2) Experimental Example 2: Confirmation of the exfoliation rate of the salicylic acid solubilized composition

[0095]

[0096] The exfoliation rate of the salicylic acid solubilizing composition prepared above was confirmed and is shown in Tables 9 to 12 below.

[0097] Fifteen healthy adult men and women with clear forearms free of pigmentation or acne were selected for the experimental group. The forearms were gently washed and dried, and then tanned by applying a 5% dihydroxyacetone (DHA) solution twice daily for two days. The skin color (L value) of the areas browned by DHA was measured, and a salicylic acid-solubilizing composition was applied twice daily for two weeks. The skin color (L value) after two weeks and the initial skin color (L value) were used to calculate the exfoliation rate using the following mathematical formula.

[0098] Exfoliation rate (%) = (L value after 14 days - L value after DHA application) / (L value before DHA application - L value after DHA application) * 100

[0099]

[0100] Classification Keratin exfoliation rate (%) Manufacturing example 121.08 Manufacturing example 221.94 Manufacturing example 322.11 Manufacturing example 422.68 Manufacturing example 523.40 Comparative manufacturing example 118.67 Comparative manufacturing example 219.85 Comparative manufacturing example 318.26

[0101] When polyol was included at 20 wt%, Preparation Examples 1 to 4, which included 1 wt% of octyldodeceth-16 and 0.1 to 3 wt% of C12-14 pareth-12, showed that the exfoliation rate increased as the content of C12-14 pareth-12 increased, and an exfoliation rate of 20.00% or more was confirmed. On the other hand, Comparative Preparation Example 1, which did not include C12-14 pareth-12, had an exfoliation rate of only 18.67%.

[0102] In addition, the exfoliation rate of Comparative Manufacturing Example 2, which was manufactured in the same manner as Manufacturing Example 1 but did not contain octyldodeceth-16, was 19.85%, which was confirmed to be a significantly lower exfoliation rate than Manufacturing Example 1.

[0103] Meanwhile, Comparative Manufacturing Example 3 containing 15 wt% of polyol had a keratin peeling rate of only 18.26%, indicating that the keratin peeling rate decreases when the polyol content is less than 20 wt%.

[0104]

[0105] Classification Keratin exfoliation rate (%) Manufacturing example 6 20.84 Manufacturing example 7 20.66 Manufacturing example 8 21.29 Manufacturing example 9 22.01 Manufacturing example 10 23.59 Manufacturing example 11 25.65 Comparative manufacturing example 4 17.49 Comparative manufacturing example 5 17.67 Comparative manufacturing example 6 18.52 Comparative manufacturing example 7 19.68

[0106] When containing 25 wt% of polyol, Preparation Examples 6 to 11 containing 1 wt% of octyldodeceth-16 and 0.1 to 4 wt% of C12-14pareth-12 showed a tendency for the exfoliation rate to increase as the content of C12-14pareth-12 increased.

[0107] Comparative Manufacturing Example 4, which does not include C12-14 pareth-12, has a keratin exfoliation rate of 17.49%, while Comparative Manufacturing Example 5, which includes 1 wt% of octyldodeceth but 0.05 wt% of C12-14 pareth-12, has a keratin exfoliation rate of only 17.67%, showing a lower keratin improvement effect compared to cases where the weight ratio of C12-14 pareth-12 to the weight of octyldodeceth is within a weight ratio of 0.1 to 10 (Manufacturing Examples 6 to 11).

[0108] Meanwhile, Comparative Manufacturing Example 6, which contains 1 wt% of C12-14pareth-12 but less than 0.5 wt% of octyldodeceth, and Comparative Manufacturing Example 7, which contains 1.5 wt% or more of octyldodeceth, showed a lower keratin improvement effect than Manufacturing Example 8, with keratin exfoliation rates of 18.52% and 19.68%, respectively.

[0109]

[0110] Classification Keratin exfoliation rate (%) Manufacturing example 1223.62 Manufacturing example 1324.02 Manufacturing example 1424.23 Manufacturing example 1524.88

[0111] When containing 30 wt% of polyol, Preparation Examples 12 to 14 containing 1 wt% of octyldodeceth-16 and 0.1 to 1 wt% of C1214pareth-12 showed exfoliation rates of 23.62%, 24.02%, and 24.88%, respectively, all of which were 20.00% or more.

[0112] In addition, when polyol was included at 35 wt%, manufacturing example 15 containing 1 wt% of octyldodeceth-16 and 1 wt% of C12-14pareth-12 was confirmed to have a keratin exfoliation rate of 24.88%.

[0113]

[0114] Comparison of exfoliation rate (%): Comparative manufacturing example 815.67 Comparative manufacturing example 920.96

[0115] Meanwhile, Comparative Manufacturing Example 8, which contains the same solubilizer and polyol as Manufacturing Example 6 but contains capryloyl salicylic acid instead of salicylic acid, showed a lower keratin improvement effect with a keratin exfoliation rate of 15.67% compared to Manufacturing Example 6 (18.37%).

[0116] In addition, Comparative Manufacturing Example 9, which contains the same solubilizer and polyol as Manufacturing Example 10 but contains capryloyl salicylic acid instead of salicylic acid, showed a lower keratin improvement effect with a keratin exfoliation rate of 20.96% compared to Manufacturing Example 10 (23.59%).

[0117]

[0118] While specific portions of the contents of this application have been described in detail above, it will be apparent to those skilled in the art that these specific descriptions merely represent preferred embodiments and do not limit the scope of this application. Therefore, the substantial scope of this application is defined by the appended claims and their equivalents.

Claims

1. Contains salicylic acid, solubilizer and polyol. The above solubilizing agent includes octyldodeceth-16 and C12-14pareth-12, A salicylic acid solubilizing composition, wherein the polyol is contained in an amount of 20 to 90 wt% based on the total weight of the composition.

2. In paragraph 1, A salicylic acid solubilizing composition, wherein the salicylic acid is contained in an amount of 1 to 6 wt% based on the total weight of the composition.

3. In paragraph 1, A salicylic acid solubilizing composition, wherein the above C12-14pareth-12 is included in a weight ratio of 0.1 to 10 based on the weight of octyldodeceth-16.

4. In paragraph 1, A salicylic acid solubilizing composition, wherein the octyldodeceth-16 is contained in an amount of more than 0.5 wt% and less than 1.5 wt% based on the total weight of the composition.

5. In paragraph 1, A salicylic acid solubilizing composition, wherein the above C12-14pareth-12 is contained in an amount of 0.01 to 10 wt% based on the total weight of the composition.

6. In paragraph 1, A salicylic acid solubilizing composition, wherein the polyol comprises at least one selected from the group consisting of propylene glycol, dipropylene glycol, methylpropanediol, butylene glycol, pentylene glycol, isopentyldiol, hexylene glycol, caprylyl glycol, glycerin, and diglycerin.

7. In paragraph 1, A salicylic acid solubilizing composition, wherein the solubilizing agent and the polyol are included in a weight ratio of 1 to 10:20 to 90.

8. In paragraph 1, A salicylic acid solubilizing composition, wherein the octyldodeceth-16, the C12-14pareth-12, and the polyol are included in a weight ratio of 1:0.1 to 10:20 to 90.

9. A cosmetic composition comprising a salicylic acid solubilizing composition according to any one of claims 1 to 8.

10. In paragraph 9, The above cosmetic composition is a cosmetic composition for removing dead skin cells.

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