In vitro diagnostic strip

Abstract

An in vitro diagnostic strip according to one embodiment of the present invention comprises: a strip main body to which a specimen is introduced; a main deployment channel formed in the strip main body, for spreading the specimen introduced to the strip main body; and a plurality of sub-deployment channels branching and extending from one side of the main deployment channel, for spreading the specimen, wherein the sub-deployment channels may include a variable flow channel part, at least a portion of the flow cross-sectional area of which is tapered.

Description

In vitro diagnostic strips

[0001] The present invention relates to an in vitro diagnostic strip, and more particularly, to an in vitro diagnostic strip having a channel structure that can collect a sample for in vitro diagnosis and facilitate the flow of the sample.

[0002] Recently, a variety of simple test reagents, diagnostic reagents, and diagnostic devices are being developed to diagnose the presence or absence of pathogen infection such as virus or bacteria, pregnancy, cancer, and harmful substances such as residual pesticides in specific raw materials such as food.

[0003] In particular, in vitro diagnostic technology is a technology that rapidly diagnoses diseases outside the body using substances derived from the human body, such as blood, feces, body fluids, and saliva, and plays an important role in clinical decision-making and is becoming an essential and specialized element in patient treatment.

[0004] An in vitro diagnostic device using this is a medical device that is used for testing using specimens such as tissue, blood, and urine collected from the human body for the purposes of disease diagnosis and prognosis, health status evaluation, disease treatment effectiveness evaluation, and prevention, and includes reagents used. Since the diagnosis is made outside the human body, it causes less burden on the body than medical devices that require insertion into the human body.

[0005] At this time, it is necessary to develop an in vitro diagnostic strip that can obtain various test results from a single sample and has a structure that allows the sample to flow smoothly for diagnosis.

[0006] One embodiment of the present invention provides an in vitro diagnostic strip that prevents a sample flowing into a sub-development channel from slowing down and allows the sample to flow smoothly through capillary action by forming a variable flow path portion in the sub-development channel with a narrowed cross-sectional area of ​​the flow.

[0007] In addition, one embodiment of the present invention provides an in vitro diagnostic strip that can prevent a sample from flowing back into a sub-distribution channel when the amount of sample is large or the flow rate is excessively fast by forming a blocking flow portion in the sub-distribution channel.

[0008] The problems to be solved by the present invention are not limited to the problems mentioned above, and other problems not mentioned herein will be clearly understood by those skilled in the art from the description below.

[0009] An in vitro diagnostic strip according to one embodiment of the present invention comprises: a strip body into which a specimen is introduced; a main development channel formed on the strip body and through which a specimen introduced into the strip body is developed; and a plurality of sub-development channels branching out and extending from one side of the main development channel and through which the specimen is developed, wherein a variable flow path portion having at least a portion of a reduced flow cross-sectional area may be formed in the sub-development channel.

[0010] The above variable flow section can be formed such that the flow cross-sectional area narrows from upstream to downstream.

[0011] The above variable flow path section can be formed so that the flow cross-sectional area is constant from upstream to downstream.

[0012] The above variable euro portion can be placed downstream from the sub-deployment channel.

[0013] An inspection hole through which light passes can be formed at the downstream end of the above sub-deployment channel.

[0014] The above variable euro portion can be positioned adjacent to the inspection hole.

[0015] The above sub-deployment channels may be extended in a plurality of vertical directions on both sides of the above main deployment channel.

[0016] The above sub-deployment channels extend in multiple numbers from both sides of the main deployment channel, and the sub-deployment channels arranged on one side of the main deployment channel and the sub-deployment channels arranged on the other side may be arranged in an alternating manner.

[0017] A first vent hole communicating with external air may be formed at the end of the above main deployment channel.

[0018] The width of the above main deployment channel can be formed to be larger than the width of the above sub deployment channel.

[0019] A vent channel is formed between the first vent hole and the end of the main deployment channel, and the vent channel may be formed to be smaller than the width of the sub deployment channel.

[0020] A second vent hole communicating with external air may be formed at each end of the above sub-deployment channel.

[0021] The strip body may include a grip portion in which a specimen injection hole into which the specimen is injected is formed; and a film-shaped channel portion coupled to one side of the grip portion and in which the main deployment channel and the sub-deployment channel are formed.

[0022] The above channel section may include a channel film in which the main deployment channel and the sub-deployment channel are formed; and a first cover film and a second cover film attached to the upper and lower surfaces of the channel film, respectively.

[0023] The channel section may include a channel film in which the main deployment channel and the sub-deployment channel are formed; a first cover film attached to an upper surface of the channel film and in which the main deployment channel and the sub-deployment channel are formed; and a second cover film attached to a lower surface of the channel film.

[0024] According to another embodiment of the present invention, an in vitro diagnostic strip comprises: a strip body into which a specimen is introduced; a main development channel formed on the strip body and through which a specimen introduced into the strip body is developed; a plurality of sub-development channels branching out and extending from one side of the main development channel and through which the specimen is developed; and an inspection hole disposed at a downstream end of the sub-development channel and through which light is transmitted, wherein a blocking flow path portion for changing the flow direction of the specimen is formed in the sub-development channel, thereby blocking the specimen from flowing in the opposite direction in the inspection hole.

[0025] The above blocking euro section can be placed at the downstream end of the sub-deployment channel.

[0026] The above blocking portion can be arranged perpendicular to the flow direction of the sub-deployment channel.

[0027] A connecting flow path section can be formed at each of the upstream and downstream ends of the above-mentioned blocking flow path section.

[0028] The above connecting portion may be formed to have a narrower width than the sub-deployment channel.

[0029] The points at which the above connecting portion is connected to the above blocking portion may be positioned differently in the width direction.

[0030] The above sub-deployment channel may be formed with a variable flow section in which at least some of the flow cross-sectional area is reduced.

[0031] The above variable flow section can be formed such that the flow cross-sectional area narrows from upstream to downstream.

[0032] The above variable flow path section can be formed so that the flow cross-sectional area is constant from upstream to downstream.

[0033] The above blocking flow path section may be arranged downstream of the sub-deployment channel, and the variable flow path section may be arranged upstream of the blocking flow path section.

[0034] According to one embodiment of the present invention, by forming a variable flow path section in which the cross-sectional flow area narrows in the sub-development channel, the sample flowing into the sub-development channel is prevented from slowing down, and the sample can flow smoothly through the capillary phenomenon.

[0035] In addition, according to one embodiment of the present invention, by forming a blocking flow path in the sub-deployment channel, it is possible to prevent the sample from flowing back into the sub-deployment channel when the amount of sample is large or the flow speed is excessively fast.

[0036] FIG. 1 is a perspective view illustrating an in vitro diagnostic strip according to one embodiment of the present invention.

[0037] FIG. 2 is an exploded perspective view illustrating a channel portion of an in vitro diagnostic strip according to one embodiment of the present invention.

[0038] FIG. 3 is an enlarged plan view illustrating one embodiment in which a variable flow path portion is formed in the channel portion of an in vitro diagnostic strip according to the present invention.

[0039] FIG. 4 is an enlarged plan view illustrating another embodiment in which a variable flow path portion is formed in the channel portion of an in vitro diagnostic strip according to the present invention.

[0040] FIG. 5 is an enlarged plan view illustrating another embodiment in which a variable flow path portion is formed in the channel portion of an in vitro diagnostic strip according to the present invention.

[0041] Figure 6 is an enlarged plan view illustrating one embodiment in which a blocking flow path portion is formed in the channel portion of an in vitro diagnostic strip according to the present invention.

[0042] Figure 7 is an enlarged plan view illustrating another embodiment in which a blocking path portion is formed in the channel portion of an in vitro diagnostic strip according to the present invention.

[0043] FIG. 8 is an enlarged plan view illustrating another embodiment in which a blocking path portion is formed in the channel portion of an in vitro diagnostic strip according to the present invention.

[0044] FIG. 9 is an enlarged plan view showing one embodiment of the variable flow path shown in FIG. 3 combined with one embodiment of the blocking flow path shown in FIG. 6.

[0045] FIG. 10 is an enlarged plan view showing one embodiment of the variable flow path shown in FIG. 4 combined with one embodiment of the blocking flow path shown in FIG. 6.

[0046] FIG. 11 is an enlarged plan view showing one embodiment of the variable flow path shown in FIG. 5 combined with one embodiment of the blocking flow path shown in FIG. 6.

[0047] The present invention is susceptible to various modifications and embodiments, and specific embodiments are illustrated and described in detail in the drawings. However, this is not intended to limit the present invention to specific embodiments, but rather to encompass all modifications, equivalents, and alternatives falling within the spirit and technical scope of the present invention. In describing the present invention, detailed descriptions of related known technologies will be omitted if they are deemed to obscure the gist of the present invention.

[0048] Terms such as first, second, etc. may be used to describe various components, but these components should not be limited by these terms. These terms are used solely to distinguish one component from another.

[0049] The terminology used in this application is only used to describe specific embodiments and is not intended to limit the present invention. The singular expression includes the plural expression unless the context clearly indicates otherwise. In this application, it should be understood that the terms "comprises" or "has" indicate the presence of a feature, number, step, operation, component, part, or combination thereof described in the specification, but do not preclude the possibility of the presence or addition of one or more other features, numbers, steps, operations, components, parts, or combinations thereof.

[0050] Additionally, throughout the specification, when we say "connected," this does not only mean that two or more components are directly connected, but also that two or more components are indirectly connected through other components, that they are electrically connected as well as physically connected, or that they are referred to by different names depending on location or function but are one.

[0051] Additionally, when described as being formed or arranged "above or below" each component, "above" or "below" includes not only cases where the two components are in direct contact with each other, but also cases where one or more other components are formed or arranged between the two components. Furthermore, when expressed as "above" or "below," it can include the meaning of a downward direction as well as an upward direction based on one component.

[0052] Hereinafter, one embodiment of an in vitro diagnostic strip according to the present invention will be described in detail with reference to the attached drawings. In the description with reference to the attached drawings, identical or corresponding components are assigned the same drawing numbers, and redundant descriptions thereof will be omitted.

[0053] FIG. 1 is a perspective view illustrating an in vitro diagnostic strip according to one embodiment of the present invention, and FIG. 2 is an exploded perspective view illustrating a channel portion of an in vitro diagnostic strip according to one embodiment of the present invention.

[0054] As shown therein, an in vitro diagnostic strip according to one embodiment of the present invention includes a strip body (10), a main development channel (212, 232) formed on the strip body (10) and through which a sample introduced into the strip body (10) is developed, and a plurality of sub development channels (216, 235) branching out and extending from one side of the main development channel (212, 232) and through which the sample is developed, and a variable flow path portion (300) having at least a portion of a flow cross-sectional area reduced may be formed in the sub development channel (216, 235).

[0055] The strip body (10) forms the overall appearance of the in vitro diagnostic strip and may be formed in a flat plate shape. The strip body (10) may include a gripping portion (100) in which a specimen injection hole (110) into which a specimen is injected is formed, and a film-shaped channel portion (200) coupled to one side of the gripping portion (100) and in which the main deployment channel (212) and the sub-deployment channel (216) are formed.

[0056] That is, the strip body (10) includes a gripping portion (100) that a worker grips to insert into an in vitro diagnostic device, and a channel portion (200) that is coupled to one end of the gripping portion (100). The gripping portion (100) may be made of a plastic material, and the channel portion (200) may be made in a film form.

[0057] A specimen input hole (110) is formed in the phage section (100), and the specimen input hole (110) is connected to the channel input hole (214), the first input hole (234), and the second input hole (244) formed in the channel section (200), respectively. A specimen input into the specimen input hole (110) can be deployed along the main deployment channel (212) and the sub deployment channel (216) formed in the channel section (200).

[0058] Referring to FIG. 2, the channel section (200) may include a channel film (210) in which the main deployment channel (212) and the sub-deployment channel (216) are formed, and cover films (230, 240) attached to the upper and lower surfaces of the channel film (210), respectively. The cover films (230, 240) may include a first cover film (230) attached to the upper surface of the channel film (210) and a second cover film (240) attached to the lower surface of the channel film (210). The first cover film (230) and the second cover film (240) may be attached to the upper and lower surfaces of the channel film (210) via double-sided tape. In this way, when the channel section (200) is configured by attaching a cover film (230, 240) to the channel film (210), it is easy to form a main development channel (212) and a sub development channel (216), and a constant contact angle can be maintained.

[0059] Here, the main deployment channel (212) and the sub-deployment channel (216) may be formed by being opened vertically on the channel film (210) that substantially constitutes the channel portion (200). In addition, cover films (230, 240) are attached to the upper and lower surfaces of the channel film (210), respectively, to form the main deployment channel (212) and the sub-deployment channel (216). In addition, the first cover film (230) may be formed with a main deployment channel (232) and a sub-deployment channel (235) corresponding to the main deployment channel (212) and the sub-deployment channel (216). The main deployment channel (232) is a portion where a sample introduced into the strip body (10) is initially deployed, and may be formed to be long along the longitudinal direction of the channel portion (200). In addition, a plurality of sub-deployment channels (235) extend vertically on both sides of the main deployment channel (232) so that a sample can be deployed through them.

[0060] Meanwhile, in this drawing, the main deployment channel (232) and the sub-deployment channel (235) are shown to be formed in the first cover film (230), but this is not limited thereto, and the main deployment channel (212) and the sub-deployment channel (216) may be formed only in the channel section (200), and the first cover film (230) may be configured to cover this.

[0061] The main deployment channel (212) is the portion where the sample introduced into the strip body (10) is initially deployed, and may be formed to be long along the length of the channel portion (200). In addition, a plurality of sub-deployment channels (216) extend vertically on both sides of the main deployment channel (212), through which the sample can be deployed. Of course, the sub-deployment channels (216) do not have to extend vertically on both sides of the main deployment channel (212), and may extend in an inclined direction.

[0062] A plurality of sub-deployment channels (216) may be formed at regular intervals along both sides of the main deployment channel (212), and the sub-deployment channels (216) arranged on one side and the other side may be arranged in an alternating manner. That is, the sub-deployment channels (216) arranged on the other side may be arranged in an alternating manner between each of the sub-deployment channels (216) arranged on one side. When the sub-deployment channels (216) are arranged in an alternating manner on both sides in this way, the specimen can smoothly flow into each sub-deployment channel (216).

[0063] An inspection hole (218) through which light from an in vitro diagnostic device is irradiated may be formed in the sub-deployment channel (216). The inspection hole (218) is a portion through which light passes from an optical module mounted on the in vitro diagnostic device, and a diagnosis can be made by determining the condition of a specimen through light penetration. Since the inspection holes (218) are formed in the sub-deployment channel (216), an operator can make various types of diagnoses from the specimens detected through each inspection hole (218). That is, in the present embodiment, since a plurality of inspection holes (218) are formed, a variety of targets can be detected as many as the number of inspection holes (218) using a single in vitro diagnostic device, and each inspection hole (218) can be used to detect the same target or different targets.

[0064] The first cover film (230) and the second cover film (240) are formed with first cover inspection holes (236) and second cover inspection holes (246) respectively having openings corresponding to the plurality of inspection holes (218) to allow light to pass through. The operator can easily check whether the reagent has been distributed throughout the channel section (200) by checking from the inspection hole (218) formed closest to the first vent hole (220).

[0065] Meanwhile, a first vent hole (220) communicating with external air is formed at the end of the main deployment channel (212). The first vent hole (220) is formed at the end of the main deployment channel (212) to allow the sample to flow well through the main deployment channel (212) and the sub-deployment channel (216) through capillary action. In addition, a second vent hole (222) communicating with external air is formed at the end of the sub-deployment channel (216). The second vent hole (222), like the first vent hole (220), also allows the sample to flow well through the capillary action.

[0066] The first vent hole (220) and the second vent hole (222) may be formed to communicate with the first cover vent hole (237) and the second cover vent hole (238) formed in the first cover film (230), respectively. In the present embodiment, the first cover vent hole (237) and the second cover vent hole (238) may be formed only in the first cover film (230), and the first cover vent hole (237) and the second cover vent hole (238) may be formed in a long slit shape so as to communicate with the first vent hole (220) and the second vent hole (222) arranged on the inside.

[0067] A vent channel (224) having a narrow path may be formed between the end of the main deployment channel (212) and the first vent hole (220). In this embodiment, the vent channel (224) is formed to be smaller than the width of the main deployment channel (212) so that a capillary phenomenon can occur easily.

[0068] To be more specific, in the present embodiment, the main deployment channel (212) is formed to be larger than the width of the sub-deployment channel (216) and the vent channel (224), and the sub-deployment channel (216) is formed to be larger than the width of the vent channel (224). That is, the widths of the channels may be formed to be larger in the order of the main deployment channel (212), the sub-deployment channel (216), and the vent channel (224). When the widths of the channels are formed differently in this way, the sample is sucked in through a capillary phenomenon in the channel side having a relatively smaller width, so the sample introduced into the main deployment channel (212) can flow more smoothly into the sub-deployment channel (216) and the vent channel (224).

[0069] According to one embodiment of the present invention, 16 sub-deployment channels (216) are formed in the main deployment channel (212), and accordingly, 16 inspection holes (218) can also be formed. According to one embodiment of the present invention, 8 inspection holes (218) and sub-deployment channels (216) connecting the inspection holes (218) and the main deployment channel (212) can be provided on one side of the main deployment channel (212). In addition, 8 inspection holes (218) and sub-deployment channels (216) can be provided on the other side of the main deployment channel (212). However, this is only one embodiment of the present invention, and a different number of sub-deployment channels (216) and inspection holes (218) may be provided.

[0070] According to one embodiment of the present invention, an enzyme for conducting an examination may be accommodated or applied to the first cover inspection hole (236) and the second cover inspection hole (246). An example of the enzyme may be bilirubin oxidase, but is not limited thereto. The examination may proceed by reacting the injected specimen with the enzyme.

[0071] Meanwhile, a hydrophilic coating layer may be formed in the portion of the cover film (230, 240) where the main development channel (212) and the sub development channel (216) are formed, thereby implementing a capillary function. Here, it is not necessary to form a hydrophilic coating layer on the cover film (230, 240), and the cover film (230, 240) may be made of a hydrophilic material or the portion may be subjected to a hydrophilic treatment (e.g., by applying a chemical reagent). If the cover film (230, 240) is not subjected to a hydrophilic treatment, the capillary phenomenon function may deteriorate, slowing down the sample injection speed, making normal sample development and measurement impossible.

[0072] FIG. 3 is an enlarged plan view illustrating one embodiment in which a variable flow path part is formed in a channel part of an in vitro diagnostic strip according to the present invention, FIG. 4 is an enlarged plan view illustrating another embodiment in which a variable flow path part is formed in a channel part of an in vitro diagnostic strip according to the present invention, and FIG. 5 is an enlarged plan view illustrating yet another embodiment in which a variable flow path part is formed in a channel part of an in vitro diagnostic strip according to the present invention.

[0073] Referring to FIG. 3, a variable flow path section (300) in which at least a portion of the flow cross-sectional area is reduced may be formed in the sub-development channel (235). In this drawing, the variable flow path section (300) is shown as being formed in the sub-development channel (235) formed in the first cover film (230), but a corresponding variable flow path section (300) may also be formed in the sub-development channel (216) of the channel section (200).

[0074] The variable flow path (300) is a portion formed to prevent the sample flowing from the main development channel (232) to the sub-development channel (235) from slowing down and to effectively suck the sample up to the first cover inspection hole (236) through a capillary phenomenon. That is, the flow of the sample may slow down in the sub-development channel (235) branched from the main development channel (232) because the flow direction in the main development channel (232) is changed to a vertical direction. Therefore, the sample may stagnate in the sub-development channel (235), but when the variable flow path (300) is formed, the flow of the sample can be smoothly achieved through a capillary phenomenon.

[0075] As illustrated in FIG. 3, the variable flow path section (300) narrows the width of a portion of the sub-development channel (235) formed in a straight line, thereby reducing the flow cross-sectional area. In one embodiment, the variable flow path section (300) may be formed to have a narrow width overall by narrowing both sides of the sub-development channel (235).

[0076] In one embodiment, the variable flow path (300) may be formed so that the flow cross-section is constant from upstream to downstream as shown in the drawing. Here, upstream refers to the point where the main development channel (232) and the sub-development channel (235) branch off, and downstream refers to the portion adjacent to the first cover inspection hole (236).

[0077] In one embodiment, the variable flow path (300) may be positioned downstream of the sub-expansion channel (235). That is, the variable flow path (300) may be positioned downstream of the sub-expansion channel (235) to maximize the capillary phenomenon and effectively suck up the specimen. The downstream end of the sub-expansion channel (235) may be positioned immediately in front of the first cover inspection hole (236).

[0078] Referring to FIG. 4, the variable flow path section (300) may be formed such that the flow cross-sectional area narrows from upstream to downstream in the sub-development channel (235). That is, the variable flow path section (300) may be formed to be tapered so that the width narrows from upstream to downstream. Here, the width of the variable flow path section (300) may be formed such that both sides narrow at the same rate from upstream to downstream, or may be formed such that the width narrows only on one side.

[0079] Referring to FIG. 5, the variable flow path section (300) may be formed to have a smaller flow cross-sectional area of ​​at least a portion of the sub-deployment channel (235). The variable flow path section (300) may be formed to have the same flow cross-sectional area from upstream to downstream. Compared to the variable flow path section (300) illustrated in FIG. 3, the variable flow path section (300) presented in this embodiment may be formed to have a narrower and longer width.

[0080] Meanwhile, the variable flow path sections (300) illustrated in FIGS. 3 to 5 are illustrated as being formed equally in each sub-deployment channel (235) in the embodiment. However, the variable flow path sections (300) do not have to have the same shape applied to all sub-deployment channels (235), and may be applied differently for each sub-deployment channel (235) depending on the characteristics of the sample, etc. For example, the variable flow path section (300) positioned on the upstream side of the main development channel (232) may apply the variable flow path section (300) illustrated in FIG. 3, and the variable flow path section (300) positioned on the downstream side of the main development channel (232) may apply the variable flow path section (300) illustrated in FIG. 5.

[0081] FIG. 6 is an enlarged plan view illustrating one embodiment in which a blocking channel portion is formed in a channel portion of an in vitro diagnostic strip according to the present invention, FIG. 7 is an enlarged plan view illustrating another embodiment in which a blocking channel portion is formed in a channel portion of an in vitro diagnostic strip according to the present invention, and FIG. 8 is an enlarged plan view illustrating yet another embodiment in which a blocking channel portion is formed in a channel portion of an in vitro diagnostic strip according to the present invention.

[0082] As shown therein, an in vitro diagnostic strip according to one embodiment of the present invention includes a strip body (10), a main development channel (212, 232) formed on the strip body (10) and through which a sample introduced into the strip body (10) is developed, and a plurality of sub development channels (216, 235) branching out and extending from one side of the main development channel (212, 232) and through which the sample is developed, and a blocking flow path (400) for changing the flow direction of the sample is formed in the sub development channel (216, 235), so as to block the sample from flowing in the opposite direction in the test hole (218, 236).

[0083] Referring to FIGS. 6 to 8, a blocking flow path (400) for changing the flow direction of a sample may be formed in the sub-development channel (235). In this drawing, the blocking flow path (400) is illustrated as being formed in the sub-development channel (235) formed in the first cover film (230), but a corresponding blocking flow path (400) may also be formed in the sub-development channel (216) of the channel portion (200). Here, the inspection holes (218, 236) may include an inspection hole (218) formed in the channel portion (200) and a first cover inspection hole (236) formed in the first cover film (230).

[0084] The sample that flows into the first cover inspection hole (236) through the sub-expansion channel (235) may flow back into the sub-expansion channel (235) again if the sample amount is large or the flow speed is excessively fast. Therefore, in the present embodiment, a blocking flow path (400) is formed in the sub-expansion channel (235) to prevent this. The blocking flow path (400) can be formed so that it can basically change to the flow direction of the sample in order to block the backflowing sample.

[0085] The blocking flow path (400) may be formed to divert at least a portion of the flow direction (linear direction) of the sub-development channel (235). In one embodiment, the blocking flow path (400) may be arranged perpendicularly at 90 degrees to the flow direction of the sub-development channel (235). When the blocking flow path (400) is formed to divert in this way to the flow direction of the sample, it is possible to restrict the sample from flowing backward toward the sub-development channel (235) when flowing backward.

[0086] Meanwhile, a connecting passage part (410) may be formed at each of the upstream and downstream ends of the blocking passage part (400). The connecting passage part (410) is a part formed to connect the blocking passage part (400) to the sub-deployment channel (235). The connecting passage part (410) may be positioned at each of the front and rear ends of the blocking passage part (400).

[0087] In addition, the connecting flow path (410) may be formed to have the same flow direction as the flow direction of the sub-expansion channel (235), unlike the blocking flow path (400). The sample introduced through the sub-expansion channel (235) may pass through the connecting flow path (410) -> blocking flow path (400) -> connecting flow path (410), and even if the sample flows back, the flow from the connecting flow path (410) to the blocking flow path (400) may be restricted.

[0088] In one embodiment, the blocking flow path (400) may be positioned at the downstream end of the sub-deployment channel (235). That is, the blocking flow path (400) may be positioned adjacent to the first cover inspection hole (236) positioned at the downstream end of the sub-deployment channel (235) to effectively block the flow of a sample flowing backward in the first cover inspection hole (236).

[0089] In one embodiment, the connecting flow path part (410) may be formed to be narrower than the sub-deployment channel (235). In one embodiment, the connecting flow path part (410) may have different positions in the width direction at the point where it is connected to the blocking flow path part (400). Referring to FIG. 6, the connecting flow path part (410) positioned on the left is positioned in the center in the width direction, and the connecting flow path part (410) positioned on the right is positioned lower in the width direction. Referring to FIG. 7, the connecting flow path part (410) positioned on the left is positioned upper in the width direction, and the connecting flow path part (410) positioned on the right is positioned lower in the width direction. In addition, referring to FIG. 8, the connecting flow path part (410) positioned on the left is positioned lower in the width direction, and the connecting flow path part (410) positioned on the right is positioned upper in the width direction.

[0090] FIG. 9 is an enlarged plan view showing an embodiment of the blocking flow path shown in FIG. 6 combined with an embodiment of the variable flow path shown in FIG. 3, FIG. 10 is an enlarged plan view showing an embodiment of the blocking flow path shown in FIG. 6 combined with an embodiment of the variable flow path shown in FIG. 4, and FIG. 11 is an enlarged plan view showing an embodiment of the blocking flow path shown in FIG. 6 combined with an embodiment of the variable flow path shown in FIG. 5.

[0091] Referring to FIGS. 9 to 11, the present embodiments combine the configuration of the variable flow path (300) illustrated in FIGS. 3 to 5 and the configuration of the blocking flow path (400) illustrated in FIGS. 6 to 8.

[0092] A variable flow path section (300) may be arranged in the sub-deployment channel (235), and a blocking flow path section (400) may be arranged downstream of the variable flow path section (300). The blocking flow path section (400) may be arranged at the downstream end of the sub-deployment channel (235). The variable flow path section (300) may be arranged immediately in front of the blocking flow path section (400), or may be arranged at a point spaced upstream. When the variable flow path section (300) and the blocking flow path section (400) are arranged together in this way, the capillary phenomenon according to the variable flow path section (300) can be maximized, while preventing the sample from flowing backward.

[0093] In FIGS. 9 to 11, only an embodiment in which the configuration of the blocking flow path section (400) illustrated in FIG. 6 and the configuration of the variable flow path section (300) illustrated in FIGS. 3 to 5 are combined in the sub-deployment channel (235) is illustrated, but this is not limited thereto, and an embodiment in which the configuration of the blocking flow path section (400) illustrated in FIGS. 7 or 8 and the configuration of the variable flow path section (300) illustrated in FIGS. 3 to 5 are also possible.

[0094] Although the present invention has been described above with reference to specific embodiments thereof, it will be understood by those skilled in the art that various modifications and changes may be made to the present invention without departing from the spirit and scope of the present invention as set forth in the claims below.

[0095] [Explanation of symbols]

[0096] 10: Strip body 100: Grab part

[0097] 110: Sample input hole 200: Channel section

[0098] 210: Channel Film 212: Main Development Channel

[0099] 214: Channel input hole 216: Sub-deployment channel

[0100] 218: Inspection Hall 220: First Vent Hall

[0101] 222: Second vent hole 224: Vent channel

[0102] 230: First cover film 232: Main development channel

[0103] 234: First injection hole 235: Sub-deployment channel

[0104] 236: First cover inspection hole 237: First cover vent hole

[0105] 238: Second cover vent hole 240: Second cover film

[0106] 244: Second input hole 246: Second cover inspection hole

[0107] 300: Variable Euro section 400: Blocking Euro section

[0108] 410: Connecting Euro Section

Claims

1. Strip body into which the sample is injected; A main development channel formed on the strip body and through which a sample introduced into the strip body is developed; and A plurality of sub-deployment channels branch out and extend from one side of the main deployment channel, and include a sub-deployment channel through which the specimen is deployed. An in vitro diagnostic strip in which a variable flow path section is formed in the above sub-deployment channel, wherein at least a portion of the flow cross-sectional area is reduced.

2. In paragraph 1, The above variable flow path is an in vitro diagnostic strip formed such that the flow cross-sectional area narrows from upstream to downstream.

3. In paragraph 1, The above variable flow path is an in vitro diagnostic strip in which the flow cross-sectional area is formed constantly from upstream to downstream.

4. In paragraph 1, The above variable flow portion is an in vitro diagnostic strip disposed downstream from the sub-deployment channel.

5. In paragraph 1, An in vitro diagnostic strip having an inspection hole through which light is transmitted formed at the downstream end of the above sub-deployment channel.

6. In paragraph 5, The above variable flow portion is an in vitro diagnostic strip positioned adjacent to the inspection hole.

7. In paragraph 1, The above sub-deployment channel is an in vitro diagnostic strip having a plurality of extending in a vertical direction on both sides of the above main deployment channel.

8. In paragraph 7, An in vitro diagnostic strip in which a plurality of sub-deployment channels extend from both sides of the main deployment channel, and the sub-deployment channels arranged on one side of the main deployment channel and the sub-deployment channels arranged on the other side are arranged in an alternating manner.

9. In paragraph 1, An in vitro diagnostic strip having a first vent hole formed at the end of the main deployment channel to communicate with external air.

10. In paragraph 1, An in vitro diagnostic strip in which the width of the main deployment channel is formed to be greater than the width of the sub deployment channel.

11. In paragraph 9, An in vitro diagnostic strip in which a vent channel is formed between the first vent hole and the end of the main deployment channel, and the vent channel is formed to be smaller than the width of the sub deployment channel.

12. In paragraph 1, An in vitro diagnostic strip in which a second vent hole communicating with external air is formed at each end of the above sub-deployment channel.

13. In paragraph 1, The above strip body is, A portion of the specimen in which a specimen injection hole into which the specimen is injected is formed; and An in vitro diagnostic strip comprising a film-shaped channel portion coupled to one side of the above-mentioned phage portion and in which the main deployment channel and the sub-deployment channel are formed.

14. In paragraph 13, The above channel section, A channel film in which the main development channel and the sub development channel are formed; and An in vitro diagnostic strip comprising a first cover film and a second cover film respectively attached to the upper and lower surfaces of the channel film.

15. In paragraph 13, The above channel section, A channel film in which the main development channel and the sub development channel are formed; A first cover film attached to the upper surface of the channel film, in which the main deployment channel and the sub-deployment channel are formed; and An in vitro diagnostic strip comprising a second cover film each attached to the lower surface of the channel film.

16. Strip body into which the sample is injected; A main development channel formed on the strip body and through which a sample introduced into the strip body is developed; A plurality of sub-deployment channels branching out and extending from one side of the main deployment channel and through which the specimen is deployed; and It is arranged at the downstream end of the above sub-deployment channel and includes an inspection hole through which light passes, An in vitro diagnostic strip having a blocking flow path formed in the above sub-development channel to change the flow direction of the sample, thereby blocking the sample from flowing in the opposite direction in the test hole.

17. In paragraph 16, The above blocking euro portion is an in vitro diagnostic strip placed at the downstream end of the sub-deployment channel.

18. In paragraph 16, An in vitro diagnostic strip in which the above blocking portion is arranged perpendicular to the flow direction of the sub-deployment channel.

19. In paragraph 16, An in vitro diagnostic strip in which a connecting section is formed at each of the upstream and downstream ends of the above-mentioned blocking section.

20. In paragraph 19, An in vitro diagnostic strip in which the above connecting portion is formed to be narrower than the sub-deployment channel.

21. In paragraph 19, An in vitro diagnostic strip in which the points at which the connecting portion is connected to the blocking portion are located differently in the width direction.

22. In paragraph 16, An in vitro diagnostic strip in which a variable flow path section is formed in the above sub-deployment channel, wherein at least a portion of the flow cross-sectional area is reduced.

23. In paragraph 22, The above variable flow path is an in vitro diagnostic strip formed such that the flow cross-sectional area narrows from upstream to downstream.

24. In paragraph 22, The above variable flow path is an in vitro diagnostic strip in which the flow cross-sectional area is formed constantly from upstream to downstream.

25. In paragraph 22, An in vitro diagnostic strip wherein the blocking flow path portion is disposed downstream of the sub-deployment channel, and the variable flow path portion is disposed upstream of the blocking flow path portion.

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