Allergen-reducing agent, and coating material, masterbatch, product, and allergen-reducing method using same

Abstract

The present invention provides an allergen-reducing agent having an excellent allergen-reducing effect. An allergen-reducing agent according to the present invention is characterized by containing magnesium oxide as an active ingredient and preferably containing at least one kind of magnesium oxide selected from the group consisting of light-burned magnesium oxide, heavy-burned magnesium oxide, and electro-fused magnesium oxide, and thus exhibits an excellent allergen-reducing effect. Moreover, an allergen-reduced product having an excellent allergen-reducing effect can be produced by incorporating the allergen-reducing agent in a substrate.

Description

Allergen reducing agent, and paint, masterbatch, product and allergen reducing method using the same

[0001] The present invention relates to an allergen-reducing agent, an allergen-reducing paint, a masterbatch for synthetic resin molding, an allergen-reducing product, and an allergen-reducing method.

[0002] In recent years, many allergic diseases such as atopic dermatitis, bronchial asthma, and allergic rhinitis have become a problem. The main causes of these allergic diseases are mites that live in homes, particularly allergens (Dermatophagoides pteronyssinus, Dermatophagoides typhimurium) that are abundant in house dust, and cedar pollen allergens (Cryj1, Cryj2) that are airborne in large quantities mainly in spring.

[0003] Therefore, there is a need for a technology that can remove allergens from living spaces or inactivate them by denaturing them.

[0004] Patent Document 1 discloses a cellulosic fiber having allergen treatment ability, characterized in that it is loaded with an allergen treatment agent containing, as an active ingredient, a nitrogen-containing compound having a specific chemical structural formula or a solvate thereof.

[0005] JP 2007-31889 A

[0006] However, the allergen treatment ability (allergen reduction effect) of the allergen treatment agent disclosed in Patent Document 1 is insufficient, and an allergen reduction agent that exhibits an excellent allergen reduction effect is desired.

[0007] The present invention provides an allergen-reducing agent having excellent allergen-reducing effects. The present invention also provides an allergen-reducing paint, a synthetic resin molding masterbatch, an allergen-reducing product, and an allergen-reducing method, which use the allergen-reducing agent.

[0008] The allergen denaturing agent of the present invention is characterized by containing magnesium oxide as an active ingredient.

[0009] The allergen-reducing paint of the present invention is characterized by comprising the allergen-reducing agent, a synthetic resin, and a solvent.

[0010] The synthetic resin molding masterbatch of the present invention is characterized by containing the allergen reducing agent and a synthetic resin.

[0011] The allergen-reduced product of the present invention is characterized by comprising a base material and the allergen-reducing agent contained in the base material.

[0012] The allergen reduction method of the present invention is characterized by comprising the step of contacting the allergen-reducing agent with an allergen.

[0013] The allergen denaturing agent of the present invention contains magnesium oxide as an active ingredient, and therefore exhibits excellent allergen denaturing effects.

[0014] In the numerical ranges described in stages in this specification, the upper or lower limit of a certain numerical range can be arbitrarily combined with the upper or lower limit of another numerical range. In the numerical ranges described in this specification, the upper or lower limit of the numerical range may be replaced with a value shown in an example or a value that can be unambiguously derived from an example. In this specification, a numerical value connected with "to" means a numerical range that includes the numbers before and after "to" as the lower and upper limits.

[0015] The allergen denaturing agent of the present invention contains magnesium oxide as an active ingredient.

[0016] [Magnesium oxide] The allergen denaturing agent contains magnesium oxide as an active ingredient. The magnesium oxide may be used alone or in combination of two or more kinds.

[0017] The content of magnesium oxide in the allergen reducing agent is preferably 50% by mass or more, more preferably 60% by mass or more, more preferably 70% by mass or more, more preferably 80% by mass or more, more preferably 90% by mass or more, more preferably 95% by mass or more, more preferably 99% by mass or more, and more preferably 100% by mass.

[0018] The content of light-burned magnesium oxide in the allergen reducing agent is preferably 50% by mass or more, more preferably 60% by mass or more, more preferably 70% by mass or more, more preferably 80% by mass or more, more preferably 90% by mass or more, more preferably 95% by mass or more, more preferably 99% by mass or more, and more preferably 100% by mass.

[0019] The content of burnt magnesium oxide in the allergen reducing agent is preferably 50% by mass or more, more preferably 60% by mass or more, more preferably 70% by mass or more, more preferably 80% by mass or more, more preferably 90% by mass or more, more preferably 95% by mass or more, more preferably 99% by mass or more, and more preferably 100% by mass.

[0020] The content of electro-fused magnesium oxide in the allergen reducing agent is preferably 50% by mass or more, more preferably 60% by mass or more, more preferably 70% by mass or more, more preferably 80% by mass or more, more preferably 90% by mass or more, more preferably 95% by mass or more, more preferably 99% by mass or more, and more preferably 100% by mass.

[0021] The magnesium oxide preferably contains at least one type of magnesium oxide selected from the group consisting of light-burned magnesium oxide, burned magnesium oxide, and fused magnesium oxide, as this improves the allergen-reducing effect of the allergen-reducing agent, and more preferably contains light-burned magnesium oxide or fused magnesium oxide.

[0022] The content of light-burned magnesium oxide in magnesium oxide is preferably 50% by mass or more, more preferably 60% by mass or more, more preferably 70% by mass or more, more preferably 80% by mass or more, more preferably 90% by mass or more, more preferably 95% by mass or more, more preferably 99% by mass or more, and more preferably 100% by mass.

[0023] The content of dead-burned magnesium oxide in magnesium oxide is preferably 50% by mass or more, more preferably 60% by mass or more, more preferably 70% by mass or more, more preferably 80% by mass or more, more preferably 90% by mass or more, more preferably 95% by mass or more, more preferably 99% by mass or more, and more preferably 100% by mass.

[0024] The content of electrofused magnesium oxide in magnesium oxide is preferably 50% by mass or more, more preferably 60% by mass or more, more preferably 70% by mass or more, more preferably 80% by mass or more, more preferably 90% by mass or more, more preferably 95% by mass or more, more preferably 99% by mass or more, and more preferably 100% by mass.

[0025] Light-burned magnesium oxide is light-burned magnesia obtained by firing a mineral containing at least one of magnesium carbonate and magnesium hydroxide as a main component at 600 to 1000°C.

[0026] The light-burned magnesium oxide preferably contains 80% by mass or more of MgO, more preferably 85% by mass or more, and even more preferably 90% by mass or more. The light-burned magnesium oxide preferably contains 99.9% by mass or less of MgO. When the MgO content in the light-burned magnesium oxide is within the above range, the allergen-reducing effect of the allergen-reducing agent is improved.

[0027] The CaO content in the light-burned magnesium oxide is preferably 0 to 3 mass%, more preferably 0 to 2.5 mass%, more preferably 0 to 2 mass%, more preferably 0.01 to 2 mass%, and even more preferably 0.01 to 1 mass%. When the CaO content in the light-burned magnesium oxide is within the above range, the allergen-reducing effect of the allergen denaturing agent is improved. "CaO content of 0 mass%" means that no CaO is contained.

[0028] The SiO2 content in the light-burned magnesium oxide is preferably 0 to 5 mass%, more preferably 0 to 3 mass%, and even more preferably 0 to 2 mass%. When the SiO2 content in the light-burned magnesium oxide is within the above range, the allergen-reducing effect of the allergen denaturing agent is improved. "SiO2 content of 0 mass%" means that no SiO2 is contained.

[0029] The Fe2O3 content in the light-burned magnesium oxide is preferably 0 to 1 mass%, more preferably 0 to 0.5 mass%, more preferably 0 to 0.4 mass%, more preferably 0.0001 to 0.1 mass%, and even more preferably 0.0005 to 0.05 mass%. When the Fe2O3 content in the light-burned magnesium oxide is within the above range, the allergen-reducing effect of the allergen denaturing agent is improved. "Fe2O3 content of 0 mass%" means that no Fe2O3 is contained.

[0030] The contents of MgO, CaO, SiO, and FeO in magnesium oxide can be measured by the Fundamental Parameter (FP) method using an energy dispersive X-ray fluorescence analyzer, such as the one commercially available from PHILIPS under the trade name "PW1404."

[0031] Burned magnesium oxide is obtained by burning a mineral containing at least one of magnesium carbonate and magnesium hydroxide as a main component at 1500°C or higher.

[0032] Electrofused magnesium oxide refers to a material produced by electro-melting magnesium oxide or a magnesium compound such as magnesium hydroxide or magnesium carbonate, and then pulverizing the resulting molten magnesium oxide, if necessary.

[0033] The MgO content in the electro-fused magnesium oxide is preferably 85% by mass or more, more preferably 90% by mass or more, more preferably 95% by mass or more, and even more preferably 96% by mass or more. The MgO content in the electro-fused magnesium oxide is preferably 99.9% by mass or less, and more preferably 99.0% by mass or less. When the MgO content in the electro-fused magnesium oxide is within the above range, the allergen-reducing effect of the allergen-reducing agent is improved.

[0034] The content of CaO in the electro-fused magnesium oxide is preferably 0 to 3 mass%, more preferably 0.001 to 2.5 mass%, more preferably 0.002 to 2 mass%, more preferably 0.005 to 1.5 mass%, more preferably 0.01 to 1 mass%, and more preferably 0.05 to 0.8 mass%. When the CaO content in the electro-fused magnesium oxide is within the above range, the allergen-reducing effect of the allergen denaturing agent is improved. "CaO content of 0 mass%" means that CaO is not contained.

[0035] The SiO2 content in the electro-fused magnesium oxide is preferably 0 to 5 mass%, more preferably 0.02 to 2 mass%, more preferably 0.03 to 1 mass%, and even more preferably 0.04 to 0.5 mass%. When the SiO2 content in the electro-fused magnesium oxide is within the above range, the allergen-reducing effect of the allergen denaturing agent is improved. "SiO2 content of 0 mass%" means that no SiO2 is contained.

[0036] The content of Fe2O3 in the electro-fused magnesium oxide is preferably 0 to 1 mass%, more preferably 0.01 to 0.5 mass%, more preferably 0.02 to 0.4 mass%, more preferably 0.025 to 0.3 mass%, and even more preferably 0.03 to 0.1 mass%. When the content of Fe2O3 in the electro-fused magnesium oxide is within the above range, the allergen-reducing effect of the allergen denaturing agent is improved. "Fe2O3 content of 0 mass%" means that no Fe2O3 is contained.

[0037] The specific surface area of ​​magnesium oxide is 0.1 m 2 / g or more is preferable, and 1m 2 / g or more is more preferable, and 5m 2 / g or more is more preferable, and 10m 2 / g or more is more preferable, and 20m 2 / g or more is preferable, and 30m 2 / g or more is preferable, and 40m 2 / g or more is preferable, and 50m 2 / g or more is more preferable, and 100m 2 The specific surface area of ​​magnesium oxide is preferably 300 m / g or more. 2 / g or less is preferable, and 250m 2 / g or less is more preferable, and 200m 2 / g or less is more preferable. 2 When the specific surface area of ​​the allergen reducing agent is 300 m / g or more, the allergen reducing effect of the allergen reducing agent is improved. 2 When the density is 1 / g or less, aggregation of the allergen-reducing agent is reduced and the agent can be uniformly contained in the base material, which tends to result in a good appearance of the allergen-reduced product.

[0038] The specific surface area of ​​magnesium oxide refers to a value measured by the BET method in accordance with ASTM D3037-93.

[0039] The D50 particle size of magnesium oxide is preferably 0.1 μm or more, more preferably 0.4 μm or more. The D50 particle size of magnesium oxide is preferably 50 μm or less, more preferably 40 μm or less, more preferably 30 μm or less, more preferably 20 μm or less, preferably 10 μm or less, more preferably 9 μm or less, and more preferably 8 μm or less. When the D50 particle size of magnesium oxide is 0.1 μm or more, aggregation of the allergen reducing agent can be reduced and it can be uniformly contained in the base material, which tends to improve the appearance of the allergen-reduced product. When the D50 particle size of magnesium oxide is 50 μm or less, the surface area of ​​the allergen reducing agent increases, which tends to improve the allergen-reducing effect of the allergen reducing agent.

[0040] The D50 particle size of magnesium oxide refers to the particle size (50% cumulative particle size) at which the cumulative frequency (cumulative from particles with small particle sizes) in the volume-based particle size distribution determined by laser scattering method is 50%.

[0041] The allergen reducing agent preferably contains a sulfonate compound or a sulfate ester salt compound, which improves the allergen reducing effect on mite allergens.

[0042] The sulfonate compound may have one or more salts of sulfo groups (-SO3X) in the molecule. X is a monovalent counter cation. X is not particularly limited and examples thereof include sodium ions, potassium ions, lithium ions, and ammonium ions. Sodium ions are preferred because they enhance the allergen-reducing effect on mite allergens.

[0043] In this specification, compounds having the structure shown in the following formula 1 in the molecule are classified as sulfate ester salt compounds. Z is a monovalent counter cation. Z is not particularly limited and examples include sodium ion, potassium ion, lithium ion, and ammonium ion, with sodium ion being preferred as it improves the allergen-reducing effect against mite allergens. * represents a bond and represents a single bond.

[0044]

[0045] The sulfonate compound is not particularly limited, and examples thereof include alkanesulfonates, linear alkylbenzenesulfonates, α-olefinsulfonates, alkyldiphenylethersulfonates, polymers having a salt of a sulfo group in the side chain of a linear polymer, salts of polystyrenesulfonic acid, salts of sulfonated (styrene-divinylbenzene copolymers), and salts of sulfonated polyethersulfones. Alkanesulfonates are preferred, as they improve the allergen-reducing effect against mite allergens, and sodium alkanesulfonate is more preferred.

[0046] Examples of alkanesulfonates include sodium alkanesulfonates such as sodium octanesulfonate, sodium decanesulfonate, sodium undecanesulfonate, sodium dodecanesulfonate, sodium tridecanesulfonate, sodium tetradecanesulfonate, sodium pentadecanesulfonate, sodium hexadecanesulfonate, and sodium octadecanesulfonate; potassium alkanesulfonates such as potassium undecanesulfonate; and lithium alkanesulfonates such as lithium decanesulfonate.

[0047] Examples of linear alkylbenzenesulfonates include sodium dodecylbenzenesulfonate, ammonium dodecylbenzenesulfonate, sodium tridecylbenzenesulfonate, ammonium tridecylbenzenesulfonate, sodium tetradecylbenzenesulfonate, and ammonium tetradecylbenzenesulfonate.

[0048] The number of carbon atoms in the alkyl group of the linear alkylbenzene sulfonate is preferably 10 or more, more preferably 11 or more, and even more preferably 12 or more. The number of carbon atoms in the alkyl group of the linear alkylbenzene sulfonate is preferably 25 or less, more preferably 20 or less, and even more preferably 18 or less. When the number of carbon atoms in the alkyl group is within the above range, the allergen-reducing effect on mite allergens is improved.

[0049] Examples of the α-olefin sulfonate include sodium C12 to C22 α-olefin sulfonate, potassium C12 to C22 α-olefin sulfonate, and ammonium C12 to C22 α-olefin sulfonate.

[0050] The number of carbon atoms in the α-olefin of the α-olefin sulfonate is preferably 12 or more, and more preferably 14 or more. The number of carbon atoms in the α-olefin of the α-olefin sulfonate is preferably 22 or less, and more preferably 18 or less. When the number of carbon atoms in the α-olefin is within the above range, the allergen-reducing effect on mite allergens is improved.

[0051] Examples of alkyl diphenyl ether sulfonates include sodium salts, potassium salts, ammonium salts, and lithium salts of alkyl diphenyl ether sulfonic acids in which the alkyl group is C6 to C24.

[0052] The number of carbon atoms in the alkyl group of the alkyl diphenyl ether sulfonate is preferably 6 or more, more preferably 8 or more, and even more preferably 10 or more. The number of carbon atoms in the alkyl group of the alkyl diphenyl ether sulfonate is preferably 24 or less, and more preferably 18 or less. When the number of carbon atoms in the alkyl group is within the above range, the allergen-reducing effect on mite allergens is improved.

[0053] The sulfate ester salt compound may have a structure shown in the following formula 1 in the molecule. In formula 1, Z is as defined above. * denotes a bond and a single bond.

[0054] The sulfate ester salt is not particularly limited, and examples thereof include alkyl sulfate ester salts and polyoxyethylene alkyl sulfate ester salts, with alkyl sulfate ester salts being preferred.

[0055] Examples of alkyl sulfates include sodium lauryl sulfate, triethanolamine lauryl sulfate, ammonium lauryl sulfate, and sodium hexadecyl sulfate, with lauryl sulfates being preferred and sodium lauryl sulfate being more preferred.

[0056] The number of carbon atoms in the alkyl group of the alkyl sulfate ester salt is preferably 5 or more, more preferably 6 or more, more preferably 7 or more, more preferably 8 or more, more preferably 9 or more, more preferably 10 or more, and more preferably 11 or more. The number of carbon atoms in the alkyl group of the alkyl sulfate ester salt is preferably 20 or less, more preferably 18 or less, more preferably 16 or less, more preferably 14 or less, and more preferably 13 or less. When the number of carbon atoms in the alkyl group of the alkyl sulfate ester salt is within the above range, the allergen-reducing effect on mite allergens is improved.

[0057] The polyoxyethylene alkyl sulfate has a structure shown in formula 2 below.

[0058]

[0059] In Formula 2, R is an alkyl group having 5 or more carbon atoms, n is the number of repeating units and is a natural number, and Z 1 is a monovalent counter cation.

[0060] In formula 2, examples of R include an octyl group, a nonyl group, a decyl group, a dodecyl group, a tetradecyl group, a hexadecyl group, an octadecyl group, etc. The alkyl group preferably has 8 to 18 carbon atoms.

[0061] In Formula 2, n is preferably 1 to 5, more preferably 1 to 4, and even more preferably 1 to 3. 1 Examples of the cation include sodium ions, potassium ions, lithium ions, and ammonium ions.

[0062] In the allergen reducing agent, the content of the sulfonate compound is preferably 10 parts by mass or more, more preferably 20 parts by mass or more, more preferably 30 parts by mass or more, more preferably 40 parts by mass or more, and more preferably 45 parts by mass or more, per 100 parts by mass of magnesium oxide. In the allergen reducing agent, the content of the sulfonate compound is preferably 90 parts by mass or less, more preferably 80 parts by mass or less, more preferably 70 parts by mass or less, more preferably 60 parts by mass or less, and more preferably 55 parts by mass or less, per 100 parts by mass of magnesium oxide. When the content of the sulfonate compound is within the above range, the allergen reducing effect against mite allergens is improved.

[0063] In the allergen reducing agent, the content of the sulfate ester salt compound is preferably 10 parts by mass or more, more preferably 20 parts by mass or more, more preferably 30 parts by mass or more, more preferably 40 parts by mass or more, and more preferably 45 parts by mass or more, per 100 parts by mass of magnesium oxide. In the allergen reducing agent, the content of the sulfate ester salt compound is preferably 90 parts by mass or less, more preferably 80 parts by mass or less, more preferably 70 parts by mass or less, more preferably 60 parts by mass or less, and more preferably 55 parts by mass or less, per 100 parts by mass of magnesium oxide. When the content of the sulfate ester salt compound is within the above range, the allergen reducing effect against mite allergens is improved.

[0064] When the allergen reducing agent contains a sulfonate compound and a sulfate ester salt compound, the total content of the sulfonate compound and the sulfate ester salt compound in the allergen reducing agent is preferably 10 parts by mass or more, more preferably 20 parts by mass or more, more preferably 30 parts by mass or more, more preferably 40 parts by mass or more, and more preferably 45 parts by mass or more, per 100 parts by mass of magnesium oxide. When the allergen reducing agent contains a sulfonate compound and a sulfate ester salt compound, the total content of the sulfonate compound and the sulfate ester salt compound in the allergen reducing agent is preferably 90 parts by mass or less, more preferably 80 parts by mass or less, more preferably 70 parts by mass or less, more preferably 60 parts by mass or less, and more preferably 55 parts by mass or less, per 100 parts by mass of magnesium oxide. When the total content of the sulfonate compound and the sulfate ester salt compound is within the above range, the allergen reducing effect against mite allergens is improved.

[0065] The sulfonate compound or sulfate ester salt compound is preferably supported on the surface of magnesium oxide. When the sulfonate compound or sulfate ester salt compound is supported on the surface of magnesium oxide, the allergen denaturing agent exhibits an excellent allergen denaturing effect against mite allergens and is easy to handle as a powder.

[0066] The amount of the sulfonate compound supported on the surface of magnesium oxide is preferably 60% by mass or more, more preferably 70% by mass or more, more preferably 80% by mass or more, more preferably 90% by mass or more, more preferably 95% by mass or more, and more preferably 100% by mass (total amount), based on 100% by mass of the sulfonate compound.

[0067] The amount of the sulfate ester salt compound supported on the surface of magnesium oxide is preferably 60% by mass or more, more preferably 70% by mass or more, more preferably 80% by mass or more, more preferably 90% by mass or more, more preferably 95% by mass or more, and more preferably 100% by mass (total amount), based on 100% by mass of the sulfate ester salt compound.

[0068] Here, the allergen reducing agent refers to an agent having an allergen reducing effect. The allergen reducing effect can be determined by measuring the allergen reduction rate for cedar pollen allergen (Cryj1) or mite allergen (Derf1) as described below, and if the allergen reduction rate for at least either allergen is 60% or more, the agent can be determined to have an allergen reducing effect.

[0069] The allergen reduction rate of an allergen reducing agent can be measured as follows: 6 parts by mass of an allergen reducing agent is mixed with 94 parts by mass of an ultraviolet-curable acrylic paint to prepare an allergen-reducing paint.

[0070] Next, a polyester film is prepared as a substrate. One side of this substrate is coated with an allergen-reducing paint to a thickness of 18 μm, and then ultraviolet light with a wavelength of 365 nm is irradiated onto the coating layer at 25° C. with an integrated light intensity of 500 mJ / cm. 2 The ultraviolet-curable acrylic paint was cured by irradiating the paint so that an allergen-reduced substrate having a coating film with a thickness of 18 μm formed on one side was produced.

[0071] An allergen solution containing 10 μg / mL of allergen is prepared by dissolving the allergen in purified water, and then phosphate-buffered saline (pH 7.4, hereinafter referred to as "PBS-T") containing 0.05 w / v% polysorbate 20 is added to the allergen solution and mixed uniformly to prepare an allergen solution containing 15 ng / mL of allergen.

[0072] The cedar pollen allergen (Cryj1) may be, for example, a product commercially available from ITEA under the trade name "Cedar Pollen Extract, Code 10103." The mite allergen (Derf1) may be, for example, a product commercially available from ITEA under the trade name "Mite Allergen Extract, Code 10102."

[0073] The allergen-reduced substrate was cut into a flat square with sides of 5 cm, and 0.4 mL of the allergen solution was dropped onto the coating. The substrate was then covered with a flat square polyethylene film with sides of 4 cm and left at 25°C for 24 hours to prepare a test solution.

[0074] Next, the amount W1 (ng / mL) of cedar pollen allergen (Cryj1) present in the test solution is measured by ELISA using an allergen measurement kit.

[0075] A blank substrate with a coating film formed on one side was prepared in the same manner as above, except that a blank paint containing only an ultraviolet-curable acrylic paint was used instead of the allergen-reduced paint. The amount of allergen present in the test solution, W0 (ng / mL), was measured in the same manner as above, except that a blank substrate was used instead of the allergen-reduced substrate. The allergen reduction rate (%) was calculated using the following formula: Allergen reduction rate (%) = 100 - (W1 / W0) x 100

[0076] The allergen reduction rate of the allergen reducing agent is preferably 70% or more, more preferably 80% or more, more preferably 85% or more, more preferably 90% or more, and even more preferably 95% or more.

[0077] The antibody effect of the allergen reducing agent is preferably 12% or less, more preferably 10% or less, and even more preferably 9% or less.

[0078] The antibody effect of an allergen-reducing agent can be measured as follows. An allergen-reduced substrate is prepared in the same manner as when measuring the allergen reduction rate. 0.4 mL of PBS-T is dropped onto the coating film of the allergen-reduced substrate, and the substrate is then covered with a flat square polyethylene film measuring 4 cm on a side, and left to stand at 25°C for 24 hours to prepare a test solution.

[0079] 100 μL of the test solution is dropped into wells of an antibody-immobilized 96-well plate included in the allergen measurement kit, and left to stand for 1 hour at 25° C. Next, the wells are washed three times with PBS-T using a plate washer.

[0080] Next, ELISA measurement is performed using the above wells to measure the amount of allergen present in the allergen solution containing 15 ng / mL of allergen, W2 (ng / mL). The effect on antibodies (%) is calculated using the following formula: Effect on antibodies (%) = 100 - (W2 / 15) x 100

[0081] [Allergen-reducing agent] The allergen-reducing agent contains magnesium oxide as an active ingredient. The method for producing the allergen-reducing agent is not particularly limited, and the allergen-reducing agent can be produced by mixing magnesium oxide, the active ingredient, with compounds to be added as needed in a commonly used manner.

[0082] Next, the usage of the allergen denaturing agent will be described. The allergen denaturing agent exerts an allergen denaturing effect on various allergens by the action of magnesium oxide. The allergen denaturing agent exerts an allergen denaturing effect on various allergens by coming into contact with the allergens.

[0083] Allergens that can be targeted by allergen reducing agents include animal allergens such as house dust mite allergens (Der1, Der2) and allergens caused by dogs and cats (Can f1, Fel d1), as well as airborne cedar pollen allergens (Cryj1, Cryj2) and plant allergens such as pollen. Particularly effective animal allergens include allergens from mites (mites are organisms of the Arthropoda class - order Acari, which are divided into seven main suborders: dorsal stigmata represented by Dermestida, tetrastigmata represented by hard mites, posterior stigmata represented by Ixodes ovatus and Ornithoides spp., middle stigmata represented by house mites and Passer mites, anterior stigmata represented by Lunanese Cheyletidylus and Tarsus cruzi, house dust mites such as Dermatophagoides farinae, astigmata represented by Tyrophagus putrescentiae, and cryptostigmata represented by Ornithoides nigricans and Neospora nigricans). However, it is particularly effective against house dust mites, which are abundant in house dust, especially in bedding, and cause allergic diseases.

[0084] The allergen-reducing agent is used, for example, by being incorporated into a substrate to which an allergen-reducing effect is to be imparted, thereby constituting an allergen-reduced product. The substrate containing the allergen-reducing agent exhibits an allergen-reducing effect as an allergen-reduced product. The manner in which the allergen-reducing agent is incorporated into the substrate is not particularly limited, and examples include (1) adhering the allergen-reducing agent to the surface of the substrate, and (2) kneading the allergen-reducing agent into the substrate, thereby incorporating the allergen-reducing agent into the substrate.

[0085] For allergen-reduced products, the content of magnesium oxide constituting the allergen-reducing agent is preferably 0.1 parts by mass or more, more preferably 0.5 parts by mass or more, and more preferably 1 part by mass or more, per 100 parts by mass of the substrate. For allergen-reduced products, the content of magnesium oxide constituting the allergen-reducing agent is preferably 20 parts by mass or less, more preferably 15 parts by mass or less, and more preferably 10 parts by mass or less, per 100 parts by mass of the substrate.

[0086] The allergen-reducing agent can be attached to the surface of a substrate by dissolving or dispersing the allergen-reducing agent in a solvent to form an allergen-reducing solution, and then applying the allergen-reducing solution to the substrate. The allergen-reducing solution may contain additives such as water-soluble solvents, oils, emulsions, and suspensions, as needed.

[0087] Examples of the solvent include water (preferably ion-exchanged water), alcohols (methyl alcohol, ethyl alcohol, propyl alcohol, etc.), hydrocarbons (toluene, xylene, methylnaphthalene, kerosene, cyclohexane, etc.), ethers (diethyl ether, tetrahydrofuran, dioxane, etc.), ketones (acetone, methyl ethyl ketone, etc.), and amides (N,N-dimethylformamide, etc.).

[0088] The content of magnesium oxide constituting the allergen-reducing agent in 100% by mass of the allergen-reducing solution is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, and even more preferably 1% by mass or more. The content of magnesium oxide constituting the allergen-reducing agent in 100% by mass of the allergen-reducing solution is preferably 20% by mass or less, more preferably 15% by mass or less, and even more preferably 10% by mass or less.

[0089] The substrate into which the allergen reducing agent is to be incorporated is not particularly limited as long as it is capable of incorporating the allergen reducing agent, and examples include synthetic resin molded bodies, paints, wallpaper, decorative sheets, flooring materials, fibers, textile products (woven fabrics, nonwoven fabrics, knitted fabrics), interior and interior materials for vehicles (for example, cars, airplanes, ships, etc.) (seats, child seats, and foams that constitute these, etc.), kitchenware, baby products, and architectural interior materials.

[0090] The synthetic resin constituting the synthetic resin molded body is not particularly limited, and examples thereof include thermoplastic resins (e.g., polyethylene, polypropylene, polyvinyl chloride, polystyrene, polyvinyl acetate, polyurethane, Teflon (registered trademark), acrylonitrile butadiene styrene resin, acrylonitrile styrene resin, acrylic resin, polyvinyl alcohol, polyamide, polyacetal, polycarbonate, modified polyphenylene ether, polyester, polyethylene terephthalate, polybutylene terephthalate, cyclic polyolefin, polyphenylene sulfide, polytetrafluoroethylene, polysulfone, polyethersulfone, polyarylate, polyether ether ketone, thermoplastic polyimide, polyamide imide, etc.), thermosetting resins (e.g., phenolic resin, epoxy resin, melamine resin, urea resin, unsaturated polyester resin, alkyd resin, silicone resin, polyurethane, thermosetting polyimide, etc.). The synthetic resins may be used alone or in combination of two or more.

[0091] The allergen-reducing agent may be kneaded into a synthetic resin. A method for kneading the allergen-reducing agent into a synthetic resin involves mixing the allergen-reducing agent with a synthetic resin raw material to prepare a resin composition, and using this resin composition to obtain an allergen-reduced product of a desired shape as a molded article by a general-purpose synthetic resin molding method. Examples of general-purpose synthetic resin molding methods include extrusion molding, injection molding, and blow molding. The synthetic resin and the allergen-reducing agent may be mixed to prepare a synthetic resin molding masterbatch, which may then be mixed with the synthetic resin raw material to produce an allergen-reduced product as a molded article by a general-purpose synthetic resin molding method.

[0092] The content of magnesium oxide constituting the allergen reducing agent in 100% by mass of the resin composition is preferably 1% by mass or more, more preferably 3% by mass or more, and more preferably 5% by mass or more. The content of magnesium oxide constituting the allergen reducing agent in 100% by mass of the resin composition is preferably 20% by mass or less, more preferably 15% by mass or less, and more preferably 10% by mass or less.

[0093] The content of magnesium oxide constituting the allergen reducing agent in 100% by mass of the synthetic resin molding masterbatch is preferably 20% by mass or more, more preferably 30% by mass or more, and even more preferably 50% by mass or more. The content of magnesium oxide constituting the allergen reducing agent in 100% by mass of the synthetic resin molding masterbatch is preferably 80% by mass or less, more preferably 70% by mass or less, and even more preferably 60% by mass or less.

[0094] Methods for physically fixing an allergen-reducing agent to fibers are described below. Examples of methods for physically fixing an allergen-reducing agent to fibers include: (1) a method in which an allergen-reducing agent is dissolved or dispersed in a solvent to prepare an allergen-reducing solution, and fibers are then immersed in the allergen-reducing solution to impregnate the fibers with the allergen-reducing solution; (2) a method in which the allergen-reducing solution is applied or sprayed onto the surface of fibers; (3) a method in which fibers are immersed in a binder in which the allergen-reducing agent is dissolved or dispersed, and the allergen-reducing agent is fixed to the fibers by the binder; and (4) a method in which a binder in which the allergen-reducing agent is dissolved or dispersed is applied or sprayed onto the surface of fibers, and the allergen-reducing agent is fixed to the fibers by the binder. In methods (1) and (2), a binder may be contained in the allergen-reducing solution. The solvent is the same as described above, and therefore further explanation is omitted.

[0095] The binder is not particularly limited as long as it can fix the allergen-reducing agent to the fiber surface. Examples of binders include synthetic resin binders such as urethane resins, such as one-component urethane resins and two-component urethane resins, silicone resins, acrylic resins, urethane acrylate resins, polyester resins, unsaturated polyester resins, alkyd resins, vinyl acetate resins, vinyl chloride resins, epoxy resins, and epoxy acrylate resins, with urethane resins being preferred.

[0096] As the paint, conventionally known paints are used, for example, oil-based paints (e.g., mixed paints, oil varnishes, etc.), cellulose paints, synthetic resin paints, etc. Paints also include photocurable paints that polymerize upon irradiation with radiation such as ultraviolet light to produce a binder component.

[0097] The paint contains a binder and a solvent. The binder and solvent may be the same as those described above. The paint may contain additives such as pigments, plasticizers, curing agents, extenders, fillers, antioxidants, thickeners, and surfactants, as long as the additives do not impair the paint's physical properties. Examples of methods for preparing an allergen-reducing paint by incorporating an allergen-reducing agent into the paint include a method in which the allergen-reducing agent and the paint are supplied to a dispersing device and mixed uniformly. Examples of dispersing devices include a high-speed mill, a ball mill, and a sand mill.

[0098] The content of magnesium oxide constituting the allergen reducing agent in 100% by mass of the allergen-reducing paint is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, and even more preferably 1% by mass or more. The content of magnesium oxide constituting the allergen reducing agent in 100% by mass of the allergen-reducing paint is preferably 20% by mass or less, more preferably 15% by mass or less, and even more preferably 10% by mass or less.

[0099] The building interior materials are not particularly limited, and examples thereof include flooring materials, wallpaper, ceiling materials, paints, doorknobs, switches, switch covers, wax, and the like.

[0100] The vehicle interior goods and materials are not particularly limited, and examples thereof include seats, child seats, seat belts, car mats, seat covers, doors, ceiling materials, floor mats, door trim, instrument panels, consoles, glove boxes, handrails, and the like.

[0101] The present invention will be described in more detail below using examples, but the present invention is not limited thereto. Specific numerical values ​​of the blending ratios (content ratios), physical property values, parameters, etc. used in the following description can be replaced with the upper limit values ​​(numeric values ​​defined as "equal to or less than") or lower limit values ​​(numeric values ​​defined as "equal to or greater than") of the blending ratios (content ratios), physical property values, parameters, etc. described in the "Summary of the Invention" and the "Description of the Invention".

[0102] The compounds used in the production of the allergen reducing agents of the Examples and Comparative Examples are shown below. [Magnesium oxide] Light-burned magnesium oxide 1 (manufactured by Kyowa Chemical Industry Co., Ltd., trade name "Kyowamag 30", MgO: 98 mass%, CaO: 0.63 mass%, and Fe2O3: 0.018 mass%) Light-burned magnesium oxide 2 (manufactured by Kyowa Chemical Industry Co., Ltd., trade name "Kyowamag MF30", MgO: 99.7 mass%, CaO: 0.06 mass%, and Fe2O3: 0.0012 mass%) Light-burned magnesium oxide 3 (manufactured by Kyowa Chemical Industry Co., Ltd., trade name "Kyowamag 150", MgO: 98 mass%, CaO: 0.78 mass%, and Fe2O3: 0.018 mass%) Light-burned magnesium oxide 4 (manufactured by Kyowa Chemical Industry Co., Ltd., trade name "Kyowamag 50", MgO: 98 mass%, CaO: 0.78 mass%, and Fe2O3: 0.018 mass%) Light-burned magnesium oxide 5 (manufactured by Kyowa Chemical Industry Co., Ltd., trade name "Pyroxuma 5301", MgO: 99.9 mass%, CaO: 0.03 mass%, Fe2O3: 0.0025 mass%). Light-burned magnesium oxide 6 (manufactured by Tateho Chemical Co., Ltd., trade name "TATEHOMAG 700", MgO: 99.2 mass%, CaO: 0.42 mass%, SiO2: 0.16 mass%, Fe2O3: 0.03 mass%). Light-burned magnesium oxide 7 (manufactured by Tateho Chemical Co., Ltd., trade name "TATEHOMAG Light-burned magnesium oxide 8 (manufactured by Tateho Chemical Co., Ltd., trade name "TATEHOMAG H-10", MgO: 98.9 mass%, CaO: 0.4 mass%, SiO2: 0.1 mass%, Fe2O3: 0.04 mass%) Light-burned magnesium oxide 9 (manufactured by Tateho Chemical Co., Ltd., trade name "TATEHOMAG 1100", MgO: 98.7 mass%, CaO: 0.47 mass%, SiO2: 0.12 mass%, Fe2O3: 0.03 mass%) Light-burned magnesium oxide 10 (manufactured by Ube Material Industries, Ltd., trade name "TATEHOMAG 1100", MgO: 98.7 mass%, CaO: 0.47 mass%, SiO2: 0.12 mass%, Fe2O3: 0.03 mass%) Electrofused magnesium oxide 1 (trade name "DENMAG KMAOH-F" manufactured by Tateho Chemical Co., Ltd.), MgO: 98.8 mass%, CaO: 0.43 mass%, SiO: 0.1 mass%, FeO: 0.05 mass%)Electrofused magnesium oxide 2 (manufactured by Tateho Chemical Co., Ltd., product name "DENMAG RA-F"), MgO: 98.8% by mass, CaO: 0.55% by mass, SiO: 0.26% by mass, FeO: 0.07% by mass)

[0103] [Magnesium hydroxide] Magnesium hydroxide 1 (manufactured by Kyowa Chemical Industry Co., Ltd., product name "200-06H") Magnesium hydroxide 2 (manufactured by Kyowa Chemical Industry Co., Ltd., product name "KISUMA5A") Magnesium hydroxide 3 (manufactured by Kyowa Chemical Industry Co., Ltd., product name "KISUMA8SN") Magnesium hydroxide 4 (manufactured by Tateho Chemical Industry Co., Ltd., product name "MAGSTAR 20") Magnesium hydroxide 5 (manufactured by Tateho Chemical Industry Co., Ltd., product name "MAGSTAR 7")

[0104] The D50 particle size and specific surface area of ​​each of the magnesium oxide and magnesium hydroxide were measured in the same manner as above, and the results are shown in Table 1.

[0105] [Sulfonate compound] Sodium alkanesulfonate (manufactured by Kao Chemical Co., Ltd., trade name "Latemul PS")

[0106] [Sulfuric acid ester salt compound] Sodium lauryl sulfate (manufactured by Kao Chemical Co., Ltd., product name "EMAL 10PT")

[0107] (Examples 1 to 12 and Comparative Examples 1 to 5) Magnesium oxide or magnesium hydroxide of the type shown in Table 1 was used as the allergen denaturing agent.

[0108] Examples 13 to 15 100 parts by mass of magnesium oxide of the type shown in Table 3 and 50 parts by mass of a sulfonate compound or 50 parts by mass of a sulfate ester salt compound of the type shown in Table 3 were prepared. 100 parts by mass of magnesium oxide and 50 parts by mass of the sulfonate compound or 50 parts by mass of the sulfate ester salt compound were supplied to 1,050 parts by mass of pure water and uniformly mixed to prepare a dispersion. The dispersion was then powdered using a spray dryer at an atomizer rotation speed of 20,000 rpm, to allow the sulfonate compound or sulfate ester salt compound to adhere (support) to the surface of the magnesium oxide. The magnesium oxide was then pulverized using a jet mill (manufactured by Nisshin Engineering Inc., trade name "SJ-500") under operating conditions of a raw material supply rate of 1 kg / h and a compressed air pressure of 0.75 MPa, yielding magnesium oxide as an allergen reducing agent having the entire amount of the sulfonate compound or sulfate ester salt compound supported (adhered) on its surface.

[0109] The allergen reduction rate and the effect on antibodies of the allergen reducing agents of the Examples and Comparative Examples were measured in the following manner, and the results are shown in Tables 1 and 3.

[0110] [Anti-allergen test (coating film)] [Measurement of allergen reduction rate of cedar pollen allergen (Cryj1) (coating film)] An allergen-reducing coating was prepared by mixing 6 parts by mass of the allergen-reducing agent obtained in the Examples and Comparative Examples with 94 parts by mass of an ultraviolet-curable acrylic coating (manufactured by Coattec Co., Ltd., product name "AI-N2"). Next, a polyester film was prepared as a substrate. One side of this substrate was coated with the allergen-reducing coating to a thickness of 18 μm using a wire bar coater #8, and then ultraviolet light with a wavelength of 365 nm was applied to the coating layer at 25°C using a UV conveyor device (manufactured by iGraphics Co., Ltd., "ECS301G1") at an integrated light dose of 500 mJ / cm. 2 The ultraviolet-curable acrylic paint was cured by irradiating the paint so that an allergen-reduced substrate having a coating film of 18 μm in thickness formed on one side thereof was produced.

[0111] A freeze-dried powder of cedar pollen allergen (Cryj1) (ITEA, product name "Cedar Pollen Extract, Code 10103") was dissolved in purified water to prepare an aqueous allergen solution containing 10 μg / mL of cedar pollen allergen (Cryj1). PBS-T (phosphate buffer containing 0.05% by mass of Tween 20 (Tokyo Chemical Industry Co., Ltd.), pH 7.4) was then added to the aqueous allergen solution and mixed uniformly to prepare an allergen solution containing 15 ng / mL of cedar pollen allergen (Cryj1).

[0112] The allergen-reduced substrate was cut into a flat square with sides of 5 cm, and 0.4 mL of the allergen solution was dropped onto the coating.The substrate was then covered with a flat square polyethylene film with sides of 4 cm and left at 25°C for 24 hours to prepare a test solution.

[0113] Next, the amount W1 (ng / mL) of cedar pollen allergen (Cryj1) present in the test solution was measured by ELISA using a cedar pollen allergen measurement kit (ITEA, product name "Cedar Pollen Allergen (Cryj1) ELISA Kit, code 10204").

[0114] A blank substrate with a coating film formed on one side was prepared in the same manner as above, except that a blank paint containing only an ultraviolet-curable acrylic paint was used instead of the allergen-reduced paint. The amount of cedar pollen allergen (Cryj1) present in the test solution, W0 (ng / mL), was measured in the same manner as above, except that a blank substrate was used instead of the allergen-reduced substrate. The allergen reduction rate (%) was calculated based on the following formula. This is shown in the "Reduction rate (%)" column for "Pollen (Cryj1) (coating film)" in Tables 1 and 3. Allergen reduction rate (%) = 100 - (W1 / W0) x 100

[0115] [Measurement of the effect of cedar pollen allergen (Cryj1) on antibodies (coating film)] An allergen-reduced substrate was prepared in the same manner as in the measurement of the allergen reduction rate of cedar pollen allergen (Cryj1). 0.4 mL of PBS-T (phosphate buffer containing 0.05% by mass of Tween 20 (Tokyo Chemical Industry Co., Ltd.), pH 7.4) was dropped onto the coating film of the allergen-reduced substrate and brought into contact with the substrate. The substrate was then covered with a flat square polyethylene film measuring 4 cm on a side and left to stand at 25°C for 24 hours to prepare a test solution.

[0116] 100 μL of the test solution was dropped into wells of an antibody-immobilized 96-well plate included in the cedar pollen allergen measurement kit (ITEA, trade name "Cedar Pollen Allergen (Cryj1) ELISA Kit, code 10204") and allowed to stand for 1 hour at 25° C. Next, the wells were washed three times with PBS-T using a plate washer (Tecan, trade name "HydroFlexPlus").

[0117] Next, ELISA was performed using the above wells to measure the amount W2 (ng / mL) of cedar pollen allergen (Cryj1) present in the allergen solution containing 15 ng / mL of cedar pollen allergen (Cryj1). The effect (%) on antibodies was calculated based on the following formula and is shown in the "Effect (%) on antibodies" column of "Pollen (Cryj1) (coating film)" in Tables 1 and 3. Effect (%) on antibodies = 100 - (W2 / 15) x 100

[0118] [Measurement of reduction rate of mite allergen (Derf1) (coating film) and effect on antibody (coating film)] Instead of freeze-dried powder of cedar pollen allergen (Cryj1), freeze-dried powder of mite allergen (Derf1) (ITEA, product name "mite (Df) culture medium extract, code 10102") was used, and instead of cedar pollen allergen measurement kit (ITEA, product name "cedar pollen allergen (Cryj1) ELISA kit, code 10204"), a mite allergen measurement kit (ITEA, product name "cedar pollen allergen (Cryj1) ELISA kit, code 10204") was used. The allergen reduction rate (%) of mite allergen (Derf1) and the effect on antibodies (%) were calculated in the same manner as for measuring the reduction rate (%) of cedar pollen allergen (Cryj1) and the effect on antibodies (%), except that a kit (trade name "mite allergen (Derf1) ELISA kit, code 10205") was used, and the results are shown in the "Reduction rate (%)" and "Effect on antibodies (%)" columns for "mite (Derf1) (coating film)" in Tables 1 and 3, respectively.

[0119] [Anti-allergen test (fiber)] [Measurement of allergen reduction rate of cedar pollen allergen (Cryj1) (fiber)] Purified water was added to 1 g of the allergen reducing agent of Examples 6 to 8, 10 to 12 and Comparative Example 4 and mixed uniformly to prepare an allergen reducing aqueous solution containing 1% by mass of the allergen reducing agent.

[0120] Next, as a substrate, polyester fiber (manufactured by Shikisen Co., Ltd., product name "Polyester Tropical Toray", basis weight 120 g / m 2 The fibers were immersed in 100 g of the allergen-reducing aqueous solution for 2 minutes. The immersed polyester fibers were squeezed with a manual mangle and dried at 120°C for 10 minutes to produce allergen-reducing fibers in which the allergen-reducing agent was fixed to the polyester fibers. In the allergen-reducing fibers, the allergen-reducing agent was fixed at 1 g / m 2 It was contained.

[0121] A freeze-dried powder of cedar pollen allergen (Cryj1) (ITEA, product name "Cedar Pollen Extract, Code 10103") was dissolved in purified water to prepare an aqueous allergen solution containing 10 μg / mL of cedar pollen allergen (Cryj1). PBS-T (phosphate buffer containing 0.05% by mass of Tween 20 (Tokyo Chemical Industry Co., Ltd.), pH 7.4) was then added to the aqueous allergen solution and mixed uniformly to prepare an allergen solution containing 15 ng / mL of cedar pollen allergen (Cryj1).

[0122] 0.4 g of the allergen-reduced fiber was placed in a zippered plastic bag, and 1 mL of the above allergen solution was dropped into it. The bag was then sealed and left to stand at 25° C. for 2 hours to prepare a test solution.

[0123] Next, the amount W1 (ng / mL) of cedar pollen allergen (Cryj1) present in the test solution was measured by ELISA using a cedar pollen allergen measurement kit (ITEA, product name "Cedar Pollen Allergen (Cryj1) ELISA Kit, code 10204").

[0124] The amount of cedar pollen allergen present in the test solution, W0 (ng / mL), was measured in the same manner as above, except that no allergen-reduced fiber was placed in the zippered plastic bag. The allergen reduction rate (%) was calculated using the following formula and is shown in the "Reduction rate (%)" column for "Pollen (Cryj1) (fiber)" in Table 2. Allergen reduction rate (%) = 100 - (W1 / W0) x 100

[0125] [Measurement of the effect of cedar pollen allergen (Cryj1) on antibodies (fiber)] Allergen-reduced fibers were prepared in the same manner as in the measurement of the allergen reduction rate for cedar pollen allergen (Cryj1). 0.4 g of the allergen-reduced fiber was placed in a zippered plastic bag, and 1 mL of PBS-T (phosphate buffer containing 0.05% by mass of Tween 20 (manufactured by Tokyo Chemical Industry Co., Ltd.), pH 7.4) was added dropwise to bring the fiber into contact with the bag. The bag was then sealed and left to stand at 25°C for 30 seconds to prepare a test solution.

[0126] 100 μL of the test solution was dropped into wells of an antibody-immobilized 96-well plate included in the cedar pollen allergen measurement kit (ITEA, trade name "Cedar Pollen Allergen (Cryj1) ELISA Kit, code 10204") and allowed to stand for 1 hour at 25° C. Next, the wells were washed three times with PBS-T using a plate washer (Tecan, trade name "HydroFlexPlus").

[0127] Next, ELISA was performed using the above wells to measure the amount W2 (ng / mL) of cedar pollen allergen (Cryj1) present in the allergen solution containing 15 ng / mL of cedar pollen allergen (Cryj1). The effect (%) on antibodies was calculated based on the following formula and recorded in the "Effect (%) on antibodies" column of "Pollen (Cryj1) (fiber)" in Table 2. It can be said that the smaller the effect (%) on antibodies, the less the allergen reducer's effect on antibodies. Effect (%) on antibodies = 100 - (W2 / 15) x 100

[0128]

[0129]

[0130]

[0131] The allergen-reducing agent of the present invention contains magnesium oxide as an active ingredient and exhibits excellent allergen-reducing effects. By incorporating the allergen-reducing agent of the present invention into various substrates, the allergen-reducing effect can be imparted to the substrates, and allergen-reduced products can be produced.

[0132] (Cross-reference to related applications) This application claims priority based on Japanese Patent Application No. 2023-144669, filed on September 6, 2023, the disclosure of which is incorporated herein by reference in its entirety.

Claims

1. An allergen reducing agent characterized by containing magnesium oxide as an active ingredient.

2. The allergen reducing agent according to claim 1, characterized in that the magnesium oxide contains at least one type of magnesium oxide selected from the group consisting of light-burned magnesium oxide, heavy-burned magnesium oxide and electrofused magnesium oxide.

3. The specific surface area of ​​the magnesium oxide is 0.1 to 300 m 2 The allergen reducing agent according to claim 1 or 2, characterized in that the allergen reducing agent has a molecular weight of 1000 to 10000.

4. An allergen reducing agent described in any one of claims 1 to 3, characterized in that the D50 particle size of the magnesium oxide is 0.1 to 50 μm.

5. The allergen reducing agent according to any one of claims 1 to 4, further comprising a sulfonate compound or a sulfate ester salt compound.

6. The allergen reducing agent according to claim 5, characterized in that the sulfonate compound or the sulfate ester salt compound is supported on the surface of the magnesium oxide.

7. An allergen-reducing paint comprising a paint and the allergen-reducing agent according to any one of claims 1 to 6 contained in the paint.

8. A masterbatch for synthetic resin molding, comprising the allergen reducing agent according to any one of claims 1 to 6 and a synthetic resin.

9. An allergen-reducing product comprising a base material and the allergen-reducing agent according to any one of claims 1 to 6 contained in the base material.

10. A method for reducing an allergen, comprising the step of contacting an allergen-reducing agent according to any one of claims 1 to 6 with an allergen.

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