Liquid sample analysis pretreatment apparatus, and liquid sample automatic measurement apparatus including same

Abstract

The present invention provides a liquid sample automatic measurement apparatus that is capable of highly accurate and precise analysis within a short period of time using a small amount of samples and reagents, is in the form of a cartridge and easy to replace, and is capable of quick on-site detection. The liquid sample automatic measurement apparatus according to one aspect of the present invention may include: a heating reactor in which the reagents and samples are accommodated; an accommodation container for accommodating a fluid heated in the heating reactor; and a filter which is disposed between the heating reactor and the accommodation container and allows the fluid to pass therethrough according to changes in pressure.

Description

Liquid sample analysis preprocessing device, and liquid sample automatic measuring device including the same

[0001] The present invention relates to a liquid sample analysis preprocessing device for converting a substance of interest in a liquid sample into a form that can be analyzed, and an automatic measuring device including the same.

[0002] Analysis of liquid samples involves a series of steps, including sample and reagent injection, chemical reaction, signal detection, waste discharge, and washing. To achieve high analytical accuracy and precision, a device capable of automatically performing the aforementioned steps is required.

[0003] Based on the technical background described above, the present invention provides a liquid sample analysis preprocessing device and a liquid sample automatic measurement device that enable high accuracy and precision analysis in a short period of time using a small amount of sample and reagent, are easy to replace in the form of a cartridge, and enable rapid detection in the field.

[0004] A liquid sample analysis preprocessing device according to one aspect of the present invention may include a heating reactor that accommodates a reagent and a sample, a receiving vessel that accommodates a fluid heated in the heating reactor, and a filter that is disposed between the heating reactor and the receiving vessel and passes the fluid according to a pressure change.

[0005] A liquid sample analysis preprocessing device according to one aspect of the present invention further includes a connector connecting the heating reactor and the receiving vessel, and the filter can be installed inside the connector.

[0006] According to one aspect of the present invention, the connector may be provided with a transport tube for moving a fluid contained inside the heating reactor.

[0007] According to one aspect of the present invention, the lower end of the transport tube may be positioned higher than the upper surface of the mixture of the sample and the reagent.

[0008] According to one aspect of the present invention, the container may contain a reagent, and the filter may include a material that impedes movement of the reagent.

[0009] According to one aspect of the present invention, an injection port for injecting a sample or reagent may be formed on the outer surface of the heating reactor.

[0010] According to one aspect of the present invention, the injection portion may be formed of a soft plug having elasticity and blocking the injection hole.

[0011] According to another aspect of the present invention, an automatic liquid sample measuring device may include a manifold including a plurality of inlets for introducing reagents and valves installed in the inlets to control the movement of the reagents and the washing solution, a liquid sample analysis preprocessing device connected to the manifold and including a heating reactor for receiving a sample, a receiving vessel for receiving a fluid heated in the heating reactor, and a filter disposed between the heating reactor and the receiving vessel for passing the fluid according to a pressure change, and a detector for receiving and detecting a sample from the liquid sample analysis preprocessing device.

[0012] According to another aspect of the present invention, the detector may be positioned adjacent to the receiving container.

[0013] According to another aspect of the present invention, the detector may be placed adjacent to the heating reactor.

[0014] As described above, the liquid sample analysis preprocessing device according to one embodiment of the present invention can include a filter to move fluid contained in a heating reactor to a receiving vessel based on pressure changes. Furthermore, the cartridge-type liquid sample analysis preprocessing device can be easily replaced, and water quality analysis can be performed on-site using drones or other devices.

[0015] In addition, by minimizing the use of components such as pumps and valves for fluid transfer between the heating reactor and the receiving vessel, the distance between the heating reactor and the receiving vessel can be shortened, thereby shortening the analysis time.

[0016] In addition, when analyzing turbid samples, accurate and precise analysis of substances of interest is possible without additional devices for turbidity correction through a pretreatment reaction by heating and a process of passing the heated fluid through a filter.

[0017] Additionally, a predetermined amount of heated fluid can be transferred to a receiving container through a transfer tube.

[0018] In addition, as the heated fluid is transferred to the receiving container by pressure change, it can be easily mixed with the reagent stored in the receiving container without a separate fluid mixing device.

[0019] In addition, reverse washing of the filter is possible in the process of returning the fluid that has completed a chemical reaction or signal detection in the above-mentioned receiving vessel to the heating reactor by cooling.

[0020] Additionally, the elastic soft stopper used as the sample, reagent injection port and cover of the heating reactor and receiving vessel can prevent the fluid from leaking during the heating reaction when the needle is removed after penetration.

[0021] In addition, the soft stopper can prevent the fluid stored in the heating reactor or receiving vessel from leaking out before and after analysis, enabling safe storage and use.

[0022] In addition, since the soft plug can inject and discharge fluid by penetrating the needle, there is no need to connect the tube for injecting and discharging fluid into the heating reactor and receiving vessel. Therefore, it is easy to apply to cartridges.

[0023] FIG. 1 is a schematic diagram illustrating a liquid sample automatic measuring device according to a first embodiment of the present invention.

[0024] FIG. 2 is a drawing showing a state in which a mixed fluid is received in a heating reactor of a liquid sample analysis pretreatment device according to a second embodiment of the present invention.

[0025] FIG. 3 is a drawing showing a state in which a mixed fluid has moved into a receiving container of a liquid sample analysis preprocessing device according to a second embodiment of the present invention.

[0026] FIG. 4 is a drawing illustrating a liquid sample analysis preprocessing device according to a third embodiment of the present invention.

[0027] Figure 5 is a top view of an automatic liquid sample measuring device according to a fourth embodiment of the present invention.

[0028] Figure 6 is a top view of an automatic liquid sample measuring device according to the fifth embodiment of the present invention.

[0029] The present invention is susceptible to various modifications and embodiments. Specific embodiments are illustrated and described in detail in the detailed description. However, this is not intended to limit the present invention to specific embodiments, but rather to encompass all modifications, equivalents, and alternatives falling within the spirit and technical scope of the present invention.

[0030] The terminology used herein is merely used to describe specific embodiments and is not intended to limit the present invention. The singular expression includes the plural expression unless the context clearly indicates otherwise. In the present invention, it should be understood that the terms "comprise" or "have" are intended to specify the presence of a feature, number, step, operation, component, part, or combination thereof described in the specification, but do not exclude in advance the possibility of the presence or addition of one or more other features, numbers, steps, operations, components, parts, or combinations thereof.

[0031] Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the attached drawings. Please note that, where possible, identical components are represented by identical reference numerals throughout the drawings. Furthermore, detailed descriptions of well-known functions and configurations that may obscure the gist of the present invention will be omitted. For the same reason, some components in the attached drawings are exaggerated, omitted, or schematically depicted.

[0032] Below, a liquid sample automatic measuring device according to the first embodiment of the present invention is described.

[0033] FIG. 1 is a schematic diagram illustrating a liquid sample automatic measuring device according to a first embodiment of the present invention.

[0034] Referring to FIG. 1, the liquid sample automatic measurement device (100) according to the first embodiment of the present invention may include a manifold (110), a pump (121), a liquid sample analysis preprocessing device (201), a first flow path (141), a second flow path (142), a sample flow path (146), a discharge flow path (145), and a detection unit (230).

[0035] The manifold (110) controls the flow of fluids such as reagents, cleaning solutions, and air. The manifold (110) is provided with a plurality of inlets (113) for introducing reagents, and a solenoid valve (114) for controlling the flow of fluids may be installed in each inlet (113). The manifold (110) is provided with a straight, long internal passage (112), and a plurality of inlets (113) are connected to the internal passage (112).

[0036] A solenoid valve (114) is installed in each inlet port (113), and the amount of reagent flowing in can be controlled by the opening time of the solenoid valve (114). The opening time of the solenoid valve (114) can be adjusted to be as short as 0.001 seconds, and thus the flow rate of the reagent can be controlled significantly more precisely than in the past.

[0037] Air can be introduced through the air inlet by the pump (121), and a negative pressure can be formed by the pump (121), through which air can be sucked into the manifold (110). The introduced air can push the reagent and sample to the liquid sample analysis preprocessing device (201) or the detector (230). Accordingly, the supply amount of the reagent and sample can be controlled by the air.

[0038] When the part connected to the first flow path (141) is referred to as the front, the air inlet can be located at the rearmost part of the manifold (110). Accordingly, after the reagents and samples are supplied, all reagents and samples remaining in the first flow path (141) can be pushed out using air.

[0039] The first flow path (141) is composed of a pipe connected to the manifold (110) and transfers reagents and samples to the liquid sample analysis preprocessing device (201). A pump (121) is connected to the first flow path (141) and can move liquid in two directions. The pump (121) can be composed of a peristaltic pump, thereby preventing the inside of the pump (121) from being contaminated by samples and reagents and enabling precise control of the input amounts of samples and reagents.

[0040] The sample path (146) is installed connected to the first path (141), and is installed connected to the first path (141) between the pump (121) and the manifold (110). The sample path (146) is connected to the first path (141) via a three-way valve (151) and transfers the collected liquid sample to the first path (141). The sample path (146) is connected to a tank (149) in which the sample is stored so that the sample can be supplied.

[0041] The second flow path (142) is connected to the first flow path (141) and supplies the reagent delivered from the first flow path (141) to the receiving container (220). The reagent may be composed of a color-developing reagent, etc., but the present invention is not limited thereto, and the reagent may be composed of various materials.

[0042] Meanwhile, a discharge channel (145) for discharging the remaining solution in the heating reactor (210) may be connected to the first flow path (141). In addition, after the heating reaction is completed, a washing liquid may be injected into the heating reactor (210), and the washing liquid used for washing the heating reactor (210) may be discharged through the discharge channel (145).

[0043] The liquid sample analysis preprocessing device (201) may include a heating reactor (210) for heating a sample, a receiving vessel (220) for receiving the heated sample, and a connector (250) for connecting the heating reactor (210) and the receiving vessel (220).

[0044] The heating reactor (210) is connected to the first flow path (141) and receives reagents and samples from the first flow path (141). The reagents and samples can be mixed within the heating reactor (210). Air introduced into the heating reactor (210) through the pump (121) can mix the reagents and samples.

[0045] A heater (161) may be installed in the heating reactor (210), and the heater (161) may be formed in various forms, such as a heating wire, an induction heating coil, an ultraviolet irradiation means, or an infrared irradiation means. The heating reactor is formed in a tubular shape that accommodates a sample and a reagent, and may be formed in various forms, such as heat-resistant glass, polymer, metal, or ceramic with light transparency.

[0046] The heating reactor (210) is provided with an injection port (212) for injecting a sample, and the injection port (212) may be formed with a stopper that blocks the injection hole. In addition, a reagent may be injected through the injection port (212).

[0047] The stopper may be formed of a flexible, elastic material. Accordingly, a sample can be injected through the stopper using a syringe or the like. However, the present invention is not limited thereto, and the injection portion (212) may be formed of a tube and valve, or may be formed in various other forms.

[0048] The injection port (212) may be formed on the periphery of the heating reactor (210) and may be positioned higher than the heater. However, the present invention is not limited thereto. Accordingly, the sample may be supplied not only through the first flow path (141) but also through the injection port (212).

[0049] The connector (250) connects the heating reactor (210) and the receiving vessel (220), and transfers the heated fluid from the heating reactor (210) to the receiving vessel (220). The connector (250) may include a lower protrusion (251) inserted into the heating reactor (210) and an upper protrusion (252) inserted into the receiving vessel (220).

[0050] A filter (253) that allows fluid to pass through depending on pressure changes may be installed in the connector (250). The filter (253) may be formed of hydrophobic or hydrophilic properties and may include a material having properties opposite to those of a reagent contained in the container (220).

[0051] For example, if the reagent stored in the receiving container (220) has hydrophilicity, the filter (253) may include a material having hydrophobicity. In addition, if the reagent contained in the receiving container (220) has hydrophobicity, the filter (253) may include a material having hydrophilicity. Accordingly, the reagent stored in the receiving container (220) cannot pass through the filter (253), and the fluid, which is a mixture of the sample and the reagent, can pass through the filter (253).

[0052] A connecting passage (254) penetrating the inside of the connector (250) is formed, and a filter (253) can be positioned between the connecting passages. Meanwhile, a transport tube (256) for moving a fluid contained inside the heating reactor (210) can be installed in the connector (250). The transport tube (256) is connected to the connecting passage (254) and sucks in the fluid heated inside the heating reactor (210).

[0053] The lower end of the transport tube (256) is positioned higher than the surface of the sample, and when the volume of the heated liquid sample expands in a sealed state and the water level rises, the liquid fluid can move through the transport tube (256). However, the present invention is not limited thereto, and the lower end of the transport tube (256) may also be positioned lower than the surface of the sample.

[0054] The receiving vessel (220) receives the fluid heated in the heating reactor (210). The receiving vessel (220) may be formed in a cylindrical shape with an internal space, but the present invention is not limited thereto. The receiving vessel (220) may be formed as a microfluidic chip having a flow path therein, and in this case, a liquid or solid reagent may be embedded in the flow path formed inside the receiving vessel (220).

[0055] The receiving vessel (220) may contain reagents such as a color-developing reagent, but the present invention is not limited thereto. If the sample itself has a color or if the concentration is measured using an electrode, the color-developing reagent may be omitted. The height of the receiving vessel (220) may be formed lower than the height of the heating reactor (210).

[0056] The receiving container (220) includes a cover (223) installed on the top, and a pressure reducing line (147) and a second flow path (142) are connected to the cover (223). A pressure reducing valve (148) for controlling the pressure inside the receiving container (220) may be installed in the pressure reducing line (147).

[0057] The detection unit (230) is installed adjacent to the receiving container (220) and detects the concentration of the target substance. The detection unit (230) may include a light source (231) that irradiates light and a photodetector (232) that measures the intensity of light. However, the present invention is not limited thereto, and the detection unit (230) may detect the concentration of the target substance by various methods such as absorption method, fluorescence method, and electrochemical method, and the present invention is not limited with respect to the configuration of the detection unit.

[0058] When a sample and a reagent are injected into the heating reactor (210), the heater (161) can heat the mixed fluid of the sample and reagent. When the mixed fluid is heated, the pressure inside the heating reactor (210) increases, and when the mixed fluid is heated above a certain temperature in a closed space, the volume of the mixed fluid expands. When the volume of the mixed fluid expands and the level of the mixed fluid rises above the lower end of the transport tube (256), when the pressure reducing valve (148) connected to the receiving vessel (220) is opened, the mixed fluid contained in the heating reactor (210) moves to the receiving vessel (220) in a liquid state through the transport tube (256) and can rise by passing through the filter (253).

[0059] When the mixed fluid rises, the reagent and the mixed fluid can react inside the receiving vessel (220), and the mixed fluid can develop color due to the reaction. When the mixed fluid develops color, the concentration of the target substance contained in the mixed solution can be detected by using the detection unit (230).

[0060] As described above, according to the present embodiment, a filter (253) that moves a fluid according to a change in pressure is installed so that when the pressure reducing valve (148) is opened after the pressure inside the heating reactor (210) rises, the fluid contained inside the heating reactor (210) can easily move to the receiving vessel (220). In addition, the installation of the filter (253) not only prevents foreign substances from moving to the receiving vessel, but also prevents the fluid located at the top from moving to the bottom. In addition, by including a transport tube (256), a liquid-state sample and reagent mixed fluid can also be easily moved when the pressure inside the heating reactor (210) rises.

[0061] Below, a liquid sample automatic measuring device according to a second embodiment of the present invention is described.

[0062] FIG. 2 is a drawing showing a state in which a mixed fluid is received in a heating reactor of a liquid sample analysis preprocessing device according to a second embodiment of the present invention, and FIG. 3 is a drawing showing a state in which a mixed fluid has moved to a receiving container of a liquid sample analysis preprocessing device according to a second embodiment of the present invention.

[0063] Referring to FIGS. 2 and 3, the automatic liquid sample measuring device (310) according to the present embodiment has the same structure as the automatic liquid sample measuring device according to the first embodiment described above, except for the liquid sample analysis preprocessing device (202), so a duplicate description of the same configuration is omitted.

[0064] The liquid sample analysis preprocessing device (202) does not have a separate tube connected and can be formed in the form of a cartridge. The liquid sample analysis preprocessing device (202) can be inserted and installed into an automatic liquid sample measurement device (310) equipped with a heater (320).

[0065] The liquid sample analysis preprocessing device (202) can be mounted on a mobile vehicle such as a drone. When the liquid sample analysis preprocessing device (202) is mounted on a drone, the drone can move to a site, collect samples, and analyze water quality on site.

[0066] The liquid sample analysis preprocessing device (202) may include a heating reactor (210) for heating a sample, a receiving vessel (220) for receiving the heated sample, and a connector (250) for connecting the heating reactor (210) and the receiving vessel (220).

[0067] The heating reactor (210) accommodates reagents and samples, and the reagents and samples can be mixed within the heating reactor (210). The heating reactor (210) is formed in a tubular shape to accommodate the samples and reagents, and can be formed of heat-resistant glass, plastic, metal, ceramic, etc. that has light transparency.

[0068] The heating reactor (210) can be inserted into the automatic liquid sample measuring device (310) with the sample injected into it, and the sample can be injected after being inserted into the automatic liquid sample measuring device (310).

[0069] The heating reactor (210) is provided with an injection port (212) for injecting a sample, and the injection port (212) may be formed of a plug that blocks the injection hole. The injection port (212) may be formed of a soft plug having elasticity. Accordingly, a sample can be injected by penetrating the injection port (212) with a syringe or the like. At this time, the syringe may include an injection needle (262) for injecting a sample and an exhaust needle (263) for exhausting air.

[0070] The injection portion (212) may be formed on the periphery of the heating reactor and may be positioned higher than the heater (320). However, the present invention is not limited thereto.

[0071] The connector (250) connects the heating reactor (210) and the receiving vessel (220), and transfers the heated fluid from the heating reactor (210) to the receiving vessel (220). The connector (250) may include a lower protrusion (251) inserted into the heating reactor (210) and an upper protrusion (252) inserted into the receiving vessel (220).

[0072] A filter (253) that allows fluid to pass through according to pressure changes may be installed in the connector (250). The filter (253) may be formed in a membrane form, but the present invention is not limited thereto, and may be formed in various forms such as a block, a plate, or a tube. The filter (253) may be formed of a hydrophobic or hydrophilic material, and may include a material having properties opposite to those of a reagent contained in the container (220). That is, the filter (253) may include a material that impedes the movement of the reagent.

[0073] For example, if the reagent contained in the receiving container (220) is hydrophilic, the filter may include a material having hydrophobic properties. Furthermore, if the reagent contained in the receiving container (220) is hydrophobic, the filter may include a material having hydrophilic properties. Accordingly, the reagent stored in the receiving container (220) cannot pass through the filter, while the fluid, which is a mixture of the sample and the reagent, can pass through the filter.

[0074] A connecting passage (254) penetrating the inside of the connector (250) is formed, and a filter (253) can be positioned between the connecting passages (254). Meanwhile, a transport tube (256) for moving a fluid contained inside the heating reactor (210) can be installed in the connector (250). The transport tube (256) is connected to the connecting passage (254) and sucks in the heated fluid inside the heating reactor (210). The lower end of the transport tube (256) is positioned higher than the upper surface of the mixture of the sample and the reagent, and when the volume of the heated liquid sample expands in a sealed state and the water level rises higher than the lower end of the transport tube (256), the liquid fluid can move through the transport tube (256).

[0075] The receiving vessel (220) receives the fluid heated in the heating reactor (210). The receiving vessel (220) includes a cover (223) installed on the upper portion, and the cover (223) may be made of elastic rubber, silicone, synthetic resin, or the like. A pressure reducing needle (261) for pressure reduction may penetrate the cover (223) to control the pressure inside the receiving vessel (220).

[0076] The detection unit (234) is composed of an electrode installed inside the receiving container (220), and the concentration of the detection target substance contained in the sample can be detected by the electrode.

[0077] After the heating reactor (210) containing the reagent is installed in the liquid sample automatic measuring device (310) equipped with the heater (320), when the sample is injected through the injection unit (212), the heater (320) can heat the mixed fluid of the sample and the reagent. When the mixed fluid is heated, the pressure inside the heating reactor (210) increases, and when the mixed fluid is heated in a sealed space, the volume of the mixed fluid expands and the level of the mixed fluid can rise higher than the lower end of the transport tube (256). As illustrated in FIG. 3, when the receiving vessel (220) is connected to atmospheric pressure by the pressure reducing needle (261), the liquid fluid moves to the receiving vessel (220) through the transport tube (256) and can rise by passing through the filter (253). When the mixed fluid is received in the receiving vessel (220), the concentration of the target substance included in the sample can be detected by the detection unit (234).

[0078] Below, a liquid sample automatic measurement device according to a third embodiment of the present invention is described.

[0079] FIG. 4 is a drawing illustrating a liquid sample analysis preprocessing device according to a third embodiment of the present invention.

[0080] Referring to FIG. 4, the automatic liquid sample measuring device (330) according to the present embodiment has the same structure as the automatic liquid sample measuring device according to the second embodiment described above, except for the liquid sample analysis preprocessing device (203), so a duplicate description of the same configuration is omitted.

[0081] The liquid sample analysis preprocessing device (203) is formed in the form of a cartridge and can be inserted and mounted in an automatic measuring device (330) in which a heater (320) is installed.

[0082] The liquid sample analysis preprocessing device (203) may include a heating reactor (210) for heating a sample, a receiving vessel (220) for receiving the heated sample, and a connector (250) for connecting the heating reactor (210) and the receiving vessel (220).

[0083] The heating reactor (210) accommodates reagents and samples, and the reagents and samples can be mixed within the heating reactor (210). The heating reactor (210) is formed in a tubular shape to accommodate the sample and reagent, and can be formed of heat-resistant glass having light transparency, or plastic, metal, ceramic, or the like.

[0084] The heating reactor (210) can be inserted into the automatic liquid sample measuring device (330) with the sample injected into it, and the sample can be injected after being inserted into the automatic liquid sample measuring device (330).

[0085] The heating reactor (210) is provided with an injection port (212) for injecting a sample, and the injection port (212) may be formed with a stopper that blocks the injection hole. The injection port (212) may be formed on the periphery of the heating reactor and may be positioned higher than the heater. However, the present invention is not limited thereto.

[0086] The connector (250) connects the heating reactor (210) and the receiving vessel (220), and transfers the heated fluid from the heating reactor (210) to the receiving vessel (220). The connector (250) may include a lower protrusion (251) inserted into the heating reactor (210) and an upper protrusion (252) inserted into the receiving vessel (220).

[0087] A filter (253) that allows fluid to pass through depending on pressure changes may be installed in the connector (250). The filter (253) may be formed of hydrophobic or hydrophilic properties and may include a material having properties opposite to those of a reagent contained in the container (220).

[0088] A connecting passage (254) penetrating the inside of the connector (250) is formed, and a filter (253) can be positioned between the connecting passages. Meanwhile, a transport tube (256) for moving a fluid contained inside the heating reactor (210) can be installed in the connector (250). The transport tube (256) is connected to the connecting passage (254) and sucks in the heated fluid inside the heating reactor (210). The lower end of the transport tube (256) is positioned lower than the upper surface of the mixture of the sample and the reagent, so that the liquid-state sample can be moved to the receiving container (220).

[0089] The receiving vessel (220) receives the fluid heated in the heating reactor (210). The receiving vessel (220) includes a cover (223) installed on the top, and the cover (223) may be made of elastic rubber, silicone, synthetic resin, or the like.

[0090] The detection unit (235) is installed adjacent to the heating reactor (210) and may include a light source (236) and a photodetector (237). However, the present invention is not limited thereto, and the detection unit (235) can detect the concentration of the target substance by various methods such as absorption method, fluorescence method, and electrochemical method, and the present invention is not limited with respect to the configuration of the detector.

[0091] After the heating reactor (210) containing the reagent is installed in the liquid sample automatic measuring device (330) equipped with a heater, when the sample is injected through the injection part (212), the heater (320) can heat the mixed fluid of the sample and the reagent. When the mixed fluid is heated, the pressure inside the heating reactor (210) increases, and when the mixed fluid is heated in a sealed space, the volume of the mixed fluid expands. Thereafter, when the receiving vessel (220) is connected to atmospheric pressure, the liquid fluid moves to the receiving vessel (220) through the transport tube (256) and can rise by passing through the filter (253).

[0092] The mixed fluid that has moved upward can react with the reagent stored inside the receiving vessel (220). Afterwards, when the heating reactor (210) is cooled, the pressure inside the heating reactor (210) becomes lower than the atmospheric pressure, and the sample moves from the receiving vessel (220) back to the heating reactor (210). The detection unit (235) can measure the concentration of the target substance in the sample that has moved from the receiving vessel (220) to the heating reactor (210).

[0093] Below, a liquid sample automatic measurement device according to the fourth embodiment of the present invention is described.

[0094] Figure 5 is a top view of an automatic liquid sample measuring device according to a fourth embodiment of the present invention.

[0095] The automatic liquid sample measuring device (401) according to the present embodiment has the same structure as the automatic liquid sample measuring device according to the second embodiment described above, except for the transfer table (410), so a duplicate description of the same configuration is omitted.

[0096] The liquid sample automatic measuring device (401) may include a transfer table (410), a liquid sample pretreatment reaction device (202), and a detection unit (230).

[0097] The transfer table (410) is formed in a circular or oval shape, and a plurality of liquid sample pretreatment reaction devices (202) can be installed on the transfer table (410). The transfer table (410) can move the liquid sample pretreatment reaction devices (202) along a circular or oval track.

[0098] The detection unit (230) includes a light source (231) and a photodetector (232), and the light source (231) and the photodetector (232) are spaced apart from each other on a transfer table (410) with a pretreatment reaction device (202) therebetween. The concentration of a plurality of pretreatment reaction devices (202) can be measured by the detection unit (230) while moving by the transfer table (410).

[0099] As described above, according to this embodiment, the concentration of a sample accommodated in a plurality of liquid sample pretreatment reaction devices (202) can be quickly measured by the detection unit (230) while moving.

[0100] Below, a liquid sample automatic measuring device according to the fifth embodiment of the present invention is described.

[0101] Figure 6 is a top view of an automatic liquid sample measuring device according to the fifth embodiment of the present invention.

[0102] The automatic liquid sample measuring device (402) according to the present embodiment has the same structure as the automatic liquid sample measuring device according to the fourth embodiment described above, except for the transfer table (420), so a duplicate description of the same configuration is omitted.

[0103] The liquid sample automatic measurement device (402) may include a transfer table (420), a liquid sample pretreatment reaction device (202), and a detection unit (230).

[0104] The transfer table (420) is formed in a straight line, and a plurality of liquid sample pretreatment reaction devices (202) can be installed on the transfer table (420). The transfer table (410) can move the liquid sample pretreatment reaction devices (202) along a straight track.

[0105] The detection unit (230) includes a light source (231) and a photodetector (232), and the light source (231) and the photodetector (232) are spaced apart from each other on a transfer table (410) with a pretreatment reaction device (202) therebetween. The concentration of a plurality of pretreatment reaction devices (202) can be measured by the detection unit (230) while moving by the transfer table (410).

[0106] As described above, according to this embodiment, the concentration of a sample accommodated in a plurality of liquid sample pretreatment reaction devices (202) can be quickly measured by the detection unit (230) while moving.

[0107] Above, one embodiment of the present invention has been described, but a person having ordinary skill in the art will be able to modify and change the present invention in various ways by adding, changing, deleting or adding components, etc., within the scope that does not depart from the spirit of the present invention described in the claims, and this will also be considered to be included within the scope of the rights of the present invention.

Claims

1. A heating reactor that accommodates reagents and samples; A receiving vessel for receiving the heated fluid in the above heating reactor; and A filter disposed between the heating reactor and the receiving vessel and passing fluid according to pressure changes; A liquid sample analysis preprocessing device for liquid sample analysis, characterized in that it includes.

2. In paragraph 1, A liquid sample analysis preprocessing device for liquid sample analysis, characterized in that it further includes a connector connecting the heating reactor and the receiving vessel, and the filter is installed inside the connector.

3. In paragraph 2, A liquid sample analysis preprocessing device for liquid sample analysis, characterized in that the connector has a transport tube installed therein for moving the fluid contained inside the heating reactor.

4. In paragraph 3, A liquid sample analysis preprocessing device for liquid sample analysis, characterized in that the lower end of the above transport tube is positioned higher than the upper surface of the mixture of the above sample and the above reagent.

5. In paragraph 1, A liquid sample analysis preprocessing device for liquid sample analysis, characterized in that the reagent is accommodated in the above-mentioned receiving container, and the filter includes a substance that impedes the movement of the reagent.

6. In paragraph 1, A liquid sample analysis preprocessing device for liquid sample analysis, characterized in that the above transport tube has an injection portion formed on the outer surface of the heating reactor for injecting a sample or reagent.

7. In paragraph 6, A liquid sample analysis preprocessing device for liquid sample analysis, characterized in that the above injection part is made of a soft stopper having elasticity and blocking the injection hole.

8. In any one of paragraphs 1 to 7, A liquid sample analysis preprocessing device for liquid sample analysis, characterized in that the liquid sample analysis preprocessing device is formed in the form of a cartridge.

9. A manifold including a plurality of inlets for introducing reagents and a valve installed in the inlets to control the movement of the reagents and the cleaning solution; A liquid sample analysis preprocessing device including a heating reactor connected to the manifold and supplied with a sample, a receiving vessel for receiving a fluid heated in the heating reactor, and a filter disposed between the heating reactor and the receiving vessel for passing the fluid according to pressure changes; and A detector that receives a sample from the above liquid sample analysis preprocessing device and detects it; An automatic liquid sample measuring device characterized by including a .

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