Oral care composition

Abstract

Described herein is an oral care composition. The oral care composition includes at least two thickening polymers selected from xanthan gum, tara gum, glucomannan, carrageenan, and algin; and glycerin, wherein the oral care composition has a viscosity of about 0.1 to about 1000 Paꞏs. The oral care composition of the present disclosure has improved rheology properties.

Description

ORAL CARE COMPOSITIONCROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims the benefit of priority from U.S. Provisional Patent Application No. 63 / 545,816, filed October 26, 2023, the disclosure of which is incorporated herein by reference.FIELD OF THE INVENTION

[0002] The present invention relates to an oral care composition.BACKGROUND OF THE INVENTION

[0003] Thickening polymers are commonly present in compositions for teeth cleaning products, such as a toothpaste formulation. A thickening polymer helps creates a smooth, creamy texture that is easy to brush with, prevents separation of the formulation, and / or improve the delivery of active ingredients. Xanthan gum is one of the most widely used thickening polymers because of its strong thickening capacity and great stability. However, the usage of xanthan gum has several side effects including increasing stringiness in the formulation. If a formulation is stringy, the formulation is normally messier during usage, and overall is less preferred to a consumer. Thus, there is a need for an oral care composition having an improved texture that may signal premiumization and creates a unique experience to a user.SUMMARY OF THE INVENTION

[0004] It has been found that combining at least two thickening polymers improves the rheology, reduce stringiness and / or provide consumer relevant benefits.

[0005] In some embodiments, an oral care composition may include at least two thickening polymers selected from xanthan gum, tara gum, glucomannan, carrageenan, and algin; and glycerin, wherein the oral care composition has a viscosity of about 0. 1 to about 1000 Pa s.

[0006] In some embodiments, the oral care composition may have a storage modulus of about 1 Pa to about 1000 Pa. In some embodiments, the oral care composition may have a loss modulus of about 10 Pa to about 1000 Pa.

[0007] In some embodiments, the oral care composition may further include an emulsifier. In some embodiments, the emulsifier may include stearyl alcohol, cetearyl alcohol, cetyl alcohol, sodium lauryl sulfate, sodium lauryl glucose carboxylate, lauryl glucoside, or a combination thereof.

[0008] In some embodiments, the at least two thickening polymers may include xanthan gum in an amount of about 0. 1 wt% to about 10 wt%, based on total weight of the composition.

[0009] In some embodiments, the at least two thickening polymers may include tara gum in an amount ofabout 0. 1 wt% to about 10 wt%, based on total weight of the composition.

[0010] In some embodiments, the at least two thickening polymers may include glucomannan in an amount of about 0. 1 wt% to about 10 wt%, based on total weight of the composition.

[0011] In some embodiments, the at least two thickening polymers may include carrageenan in an amount of about 0. 1 wt% to about 10 wt%, based on total weight of the composition.

[0012] In some embodiments, the at least two thickening polymers may include algin in an amount of about 0. 1 wt% to about 10 wt%, based on total weight of the composition.

[0013] In some embodiments, the at least two thickening polymers may include xanthan gum and tara gum.

[0014] In some embodiments, the oral care composition may further include sorbitol. In some embodiments, the sorbitol may be included in an amount of about 20 wt% to about 60 wt%, based on total weight of the composition. In some embodiments, the oral care composition may further include an antioxidant. In some embodiments, the antioxidant comprises panthenol, ascorbic acid, tocopherol, or a combination thereof.

[0015] In some embodiments, the oral care composition may further include sodium fluoride, sodium benzoate, sodium saccharin, or a combination thereof.

[0016] In some embodiments, the oral care composition may further include at least one ingredient selected from the group consisting of desensitizing agents, chelating agents, whitening agents, tartar control agents, detergents, adhesion agents, an abrasive, foam modulators, pH modifying agents, mouth-feel agents, sweeteners, flavoring agents, colorants, preservatives, humectant, or a combination thereof.

[0017] In some embodiments, the oral care composition may further include an abrasive. In some embodiments, the abrasive may include silica, polyorganosileequioxane, calcium pyrophosphate, poly(methyl methacrylate), calcium carbonate, dicalcium phosphate, barium sulfate, or a combination thereof. In some embodiments, the silica may be hydrated silica.

[0018] In some embodiments, the composition may further include a surfactant. In some embodiments, the surfactant may include sodium lauryl glucose carboxylate, lauryl glucoside, coco glucoside, decyl glucoside, capylyl / capyl glucoside, sodium cocyl glutamate, potassium cocoyl glycinate, disodium 2- sulfolaurate, or a combination thereof.

[0019] In some embodiments, the oral care composition is a product selected from an oral gel or a liquid paste.

[0020] In another embodiment, a method of cleaning may incldue applying to a surface of a mammalian tooth the oral care composition according to the present disclosure.

[0021] BRIEF DESCRIPTION OF THE DRAWINGS

[0022] The disclosure described herein is illustrated by way of example and not by way of limitation in the accompanying figures.

[0023] Figure 1 is a comparison of viscosity over a range of shear stress for a variety of thickening polymers according to the Example;

[0024] Figure 2 is a comparison of cohesion properties for the variety of thickening polymers according to the Example;

[0025] Figure 3 is a comparison of adhesion properties for the variety of thickening polymers according to the Example;

[0026] Figure 4 is the viscosity profile comparing Sample and a benchmark of the Example;

[0027] Figure 5 is a stringiness comparison demonstration of the Example; andFigure 6 is sensory evaluation result by a consumer panel of the Example. Pairwise comparison of product Polymer Toothpaste Prototype with reference product Pacebo Toothpaste in different variables. Each line shows a pairwise comparison in a variable (median & weighted dev.). Filled symbol: Wilcoxon test. P-value: see legend to the figure. Empty symbol: lower 90%-confidence bound (l.c.b.) for zero values. Square (□): l.c.b. >0.66667; Circle (o): l.c.b. <0.66667.DETAILED DESCRIPTION OF THE INVENTION

[0028] Oral care compositions can include fluoride, peroxide, abrasives, flavors and other ingredients to provide benefits like reducing plaque and tartar, preventing cavities, preventing and reversing gingivitis, building protection against sensitivity, freshening bad breath, and whitening teeth. Oral care compositions also include a thickening polymer, particularly xanthan gum, to thicken the composition. Oral care compositions including xanthan gum have issues in stability and texture of the composition.

[0029] Embodiments of the present invention advantageously provide an oral care composition including xanthan gum in combination with at least one thickening polymer for improved rheology, with a reduction in stringiness in the texture of the composition. The at least one thickening polymer is selected from tara gum, glucomannan, alginate, or carrageenan. Embodiments further advantageously utilize a xanthan gum in a combination with at least one additional thickening polymer to improve the overall texture of the oral care composition.

[0030] In one embodiment, the oral care composition includes at least two thickening polymers. The at least two thickening polymers may be selected from xanthan gum, tara gum, glucomannan, carrageenan, and algin. The oral care composition may further include glycerin. The oral care composition may have a viscosity of about 0.1 to about 1000 Pa s. In some embodiments, the oral care composition may have a stable viscosity. A stable viscosity may include maintain a viscosity range of about 1000 Pa s to about25,000 Pa s. In some embodiments, the oral care composition may have a pH of about 5.5 to about 10.

[0031] Various embodiments are described hereinafter. It should be noted that the specific embodiments are not intended as an exhaustive description or as a limitation to the broader aspects discussed herein. One aspect described in conjunction with a particular embodiment is not necessarily limited to that embodiment and can be practiced with any other embodiment(s).

[0032] As used herein, “about” will be understood by persons of ordinary skill in the art and will vary to some extent depending upon the context in which it is used. If there are uses of the term which are not clear to persons of ordinary skill in the art, given the context in which it is used, “about” will mean up to plus or minus 10% of the particular term.

[0033] The articles “a”, “an”, and “the” are used herein to refer to one or to more than one (i.e., to at least one) of the grammatical object of the article. By way of an example, “a filter” means one filter or more than one filter.

[0034] Unless explicitly stated otherwise, all percentages stated in connection with the compositions herein described refer to a weight percent, respectively based on the mixture or composition in question.

[0035] Recitation of ranges of values herein are merely intended to serve as a shorthand method of referring individually to each separate value falling within the range, unless otherwise indicated herein, and each separate value is incorporated into the specification as if it were individually recited herein. All methods described herein can be performed in any suitable order unless otherwise indicated herein or otherwise clearly contradicted by context.

[0036] The use of any and all examples, or exemplary language (e.g., “such as”) provided herein, is intended merely to illuminate certain materials and methods and does not pose a limitation on scope. No language in the specification should be construed as indicating any non-claimed element as essential to the practice of the disclosed materials and methods.

[0037] The composition can contain, consist of, or consist essentially of, the essential elements and limitations of the invention described herein, as well as any additional or optional ingredients, components, or limitations described herein or otherwise useful in oral care compositions.

[0038] As used herein, “oral care composition” is meant as a product, which in the ordinary course of usage, is not intentionally swallowed for purposes of systemic administration of particular therapeutic agents but is rather retained in the oral cavity for a time sufficient to contact dental surfaces or oral tissues. Examples of oral care compositions include dentifrice, mouth rinse, mousse, foam, mouth spray, lozenge, chewable tablet, chewing gum, tooth whitening strips, whitening gels, toothpaste, floss and floss coatings, breath freshening dissolvable strips, denture care, or adhesive product. The oral care composition may also be incorporated into strips or films for direct application or attachment to oral surfaces.

[0039] As used herein, the term “dentifrice” includes tooth or subgingival paste, gel or liquid formulationsunless otherwise specified. The dentifrice composition may be a single phase composition or may be a combination of two or more separate dentifrice compositions. The dentifrice composition may be in any desired form, such as deep striped, surface striped, multilayered, having a gel surrounding a paste, or any combination thereof. Each dentifrice composition in a dentifrice comprising two or more separate dentifrice compositions may be contained in a physically separated compartment of a dispenser and dispensed side- by-side.

[0040] As used herein, the term “dispenser” refers to any pump, tube or container suitable for dispensing compositions such as dentifrices.

[0041] As used herein, the term “teeth” refers to natural teeth, artificial teeth or dental prosthesis.

[0042] In one embodiment, the oral care composition includes at least two thickening polymers. The at least two thickening polymers may be selected from xanthan gum, tara gum, glucomannan, carrageenan, and algin. The oral care composition may further include glycerin. The oral care composition may have a viscosity of about 0. 1 to about 1000 Pa- s. In some embodiments, the viscosity of the oral care composition may be about 0.5 to about 950 Pa s, about 1 to about 900 Pa s, about 5 to about 850 Pa s, about 10 to about 800 Pa s, about 20 to about 750 Pa s, about 30 to about 700 Pa s, about 40 to about 650 Pa s, about 50 to about 600 Pa s, about 60 to about 550 Pa s, about 70 to about 500 Pa s, about 80 to about 450 Pa s, about 90 to about 400 Pa s, about 100 to about 350 Pa s, about 150 to about 300 Pa s, or about 200 to about 250 Pa s, or any value or sub-range herein.

[0043] It has been found that including at least two thickening polymers achieves a unique viscosity profile of the oral care composition. In some embodiments, the at least two thickening polymers may include xanthan gum in combination with at least one thickening polymer, which was found to form a unique viscosity profiles of the oral care composition, forming new textures of the oral care composition.

[0044] It was found that including an emulsifier in the oral care composition balanced the viscosity and texture of the composition.

[0045] In an embodiment of the present disclosure, the oral care composition may have a storage modulus of about 1 Pa to about 1000 Pa. In some embodiments, the storage modulus of the oral care composition may be about 5 Pa to about 975 Pa, about 10 Pa to about 950 Pa, about 25 Pa to about 925 Pa, about 50 Pa to about 900 Pa, about 75 Pa to about 875 Pa, about 100 Pa to about 850 Pa, about 125 Pa to about 825 Pa, about 150 Pa to about 800 Pa, about 175 Pa to about 775 Pa, about 200 Pa to about 750 Pa, about 225 Pa to about 725 Pa, about 250 Pa to about 700 Pa, about 275 Pa to about 675 Pa, about 300 Pa to about 650 Pa, about 325 Pa to about 625 Pa, about 350 Pa to about 600 Pa, about 375 Pa to about 575 Pa, about 400 Pa to about 550 Pa, or about 425 Pa to about 525 Pa, or any value or sub-range herein.

[0046] In an embodiment of the present disclosure, the oral care composition may have a loss modulus of about 10 Pa to about 1000 Pa. In some embodiments, the loss modulus of the oral care composition maybe about 25 Pa to about 975 Pa, about 50 Pa to about 950 Pa, about 75 Pa to about 925 Pa, about 100 Pa to about 900 Pa, about 125 Pa to about 875 Pa, about 150 Pa to about 850 Pa, about 175 Pa to about 825 Pa, about 200 Pa to about 800 Pa, about 225 Pa to about 775 Pa, about 250 Pa to about 750 Pa, about 275 Pa to about 725 Pa, about 300 Pa to about 700 Pa, about 325 Pa to about 675 Pa, about 350 to about 650 Pa, about 375 Pa to about 625 Pa, about 400 Pa to about 600 Pa, or about 450 Pa to about 550 Pa, or any value or subrange herein.

[0047] In some embodiments, the oral care composition may further include an emulsifier. The emulsifier may include stearyl alcohol, cetearyl alcohol, cetyl alcohol, stearyl alcohol and sodium lauryl sulfate, sodium lauryl glucose carboxylate, lauryl glucoside, or a combination thereof. In some embodiments, the emulsifier may be sodium lauryl glucose carboxylate and lauryl glycoside.

[0048] In some embodiments, the at least two thickening polymers may include xanthan gum in an amount of about 0. 1 wt% to about 10 wt%, based on total weight of the composition. In other embodiments, the xanthan gum may be included in an amount of about 0.5 wt% to about 9.5 wt%, about 1 wt% to about 9 wt%, about 1.5 wt% to about 8.5 wt%, about 2 wt% to about 8 wt%, about 2.5 wt% to about 7.5 wt%, about 3 wt% to about 7 wt%, about 4.5 wt% to about 6.5 wt%, or about 5 wt% to about 6 wt%, or any value or sub-range herein, based on total weight of the composition.

[0049] In some embodiments, the at least two thickening polymers may include tara gum. The tara gum may be included in an amount of about 0. 1 wt% to about 10 wt%, based on total weight of the composition. In other embodiments, the tara gum may be included in an amount of about 0.5 wt% to about 9.5 wt%, about 1 wt% to about 9 wt%, about 1.5 wt% to about 8.5 wt%, about 2 wt% to about 8 wt%, about 2.5 wt% to about

[0050] 7.5 wt%, about 3 wt% to about 7 wt%, about 4.5 wt% to about 6.5 wt%, or about 5 wt% to about 6 wt%, or any value or sub-range herein, based on total weight of the composition.

[0051] In some embodiments, the at least two thickening polymers may include glucomannan. The glucomannan may be included in an amount of about 0. 1 wt% to about 10 wt%, based on total weight of the composition. In other embodiments, the glucomannan may be included in an amount of about 0.5 wt% to about 9.5 wt%, about 1 wt% to about 9 wt%, about 1.5 wt% to about 8.5 wt%, about 2 wt% to about 8 wt%, about 2.5 wt% to about 7.5 wt%, about 3 wt% to about 7 wt%, about 4.5 wt% to about

[0052] 6.5 wt%, or about 5 wt% to about 6 wt%, or any value or sub-range herein, based on total weight of the composition.

[0053] In some embodiments, the at least two thickening polymers may include carrageenan. The carrageenan may be included in an amount of about 0.1 wt% to about

[0054] 10 wt%, based on total weight of the composition. In other embodiments, the carrageenan may be included in an amount of about 0.5 wt% to about 9.5 wt%, about 1 wt% to about 9 wt%, about 1.5 wt% toabout 8.5 wt%, about 2 wt% to about 8 wt%, about 2.5 wt% to about 7.5 wt%, about 3 wt% to about 7 wt%, about 4.5 wt% to about

[0055] 6.5 wt%, or about 5 wt% to about 6 wt%, or any value or sub-range herein, based on total weight of the composition.

[0056] In some embodiments, the at least two thickening polymers may include algin. The algin may be included in an amount of about 0.1 wt% to about 10 wt%, based on total weight of the composition. In other embodiments, the algin may be included in an amount of about 0.5 wt% to about 9.5 wt%, about 1 wt% to about 9 wt%, about 1.5 wt% to about 8.5 wt%, about 2 wt% to about 8 wt%, about 2.5 wt% to about 7.5 wt%, about 3 wt% to about 7 wt%, about 4.5 wt% to about 6.5 wt%, or about 5 wt% to about 6 wt%, or any value or sub-range herein, based on total weight of the composition.

[0057] In some embodiments, the at least two thickening polymers of the oral care composition may include xanthan gum and tara gum.

[0058] In some embodiments, the oral care composition may further include sorbitol. In some embodiments, the sorbitol may be included in an amount of about 20 wt% to about 60 wt%, based on total weight of the composition. In another embodiment, the sorbitol may be included in an amount of about 25 wt% to about 55 wt%, about 30 wt% to about 50 wt%, or about 35 wt% to about 45 wt%, based on total weight of the composition.

[0059] In some embodiments, the oral care composition may further include an antioxidant. The antioxidant may include panthenol, ascorbic acid, tocopherol, and other polyphenols. In some embodiments, the other polyphenol may include resveratrol, phenolic acid, quercetin, catechin, epigallocatechin gallate, anthocyanins, flavonols, curcumin, isoflavones, gallic acid, lignan, flavanones, stilbenoid, flavones, flavanols, chlorogenic acid, kaempferol, tannin, tannic acid, or epigallocatechin gallate. In another embodiment, the other polyphenols may include tannic acid, catechin, resveratrol, gallic acid, or epigallocatechin gallate. In an embodiment, the antioxidant is panthenol.

[0060] In an embodiment, the antioxidant is included in an amount of about 0.1 wt% to about 10 wt%. In other embodiments, the antioxidant may be included in an amount of about 0.25 wt% to about 9.5 wt%, about 0.75 wt% to about 9 wt%, about 1 wt% to about 8.5 wt%, about 1.5 wt% to about 8 wt%, about 2 wt% to about 7.5 wt%, about 3 wt% to about 7 wt%, about 4.5 wt% to about 6.5 wt%, or about 5 wt% to about 6 wt%, or any value or sub-range herein, based on total weight of the composition.

[0061] In some embodiments, the oral care composition may further include sodium fluoride, sodium benzoate, sodium saccharin, or a combination thereof. In some embodiments, the sodium fluoride may be included in an amount of about 0.01 wt% to about 5 wt%, based on total weight of the composition. In some embodiments, the sodium benzoate may be included in an amount of about 0. 1 wt% to about 10 wt%, based on total weight of the composition. In some embodiments, the sodium saccharin may be included inan amount of about 0.01 wt% to about 5 wt%, based on total weight of the composition.

[0062] In some embodiments, the oral care composition may include at least one excipient. Excipients suitable for use include any compound that is conventionally used in oral care compositions. Suitable excipients for an oral composition may be selected from preservatives, abrasives (smoothing agents), antibacterial agents, inflammation- inhibiting agents, irritation-preventing agents, irritation-inhibiting agents, antimicrobial agents, antioxidants, binders, (mineral) fillers, buffers, carrier materials, chelating agents, cleaning agents, care agents, surface-active substances, enzymes, foam-forming agents, foam stabilizers, foam boosters, gelling agents, gel-forming agents, bleaching agents, smell-and / or tastemodulating agents, smell-and / or taste reducing agents, smell and / or taste enhancing agents, plasticizers, skin cooling agents, skin soothing agents, skin cleansing agents, skin care agents, skin healing agents, mucous membrane- protecting agents, stabilizers, suspending agents, vitamins, colorants, color-protecting agents, pigments, surfactants, electrolytes, silicone derivatives, polyols, calcium carbonate, calcium hydrogen phosphate, aluminum oxide, fluorides, zinc, tin, potassium, sodium and strontium salts, pyrophosphates, or hydroxyapatites.

[0063] In some embodiments, an oral care composition in accordance with the present invention includes at least one excipient, wherein the at least one excipient is chosen from: surfactants, desensitizing agents, whitening agents, tartar control agents, antibacterial agents, abrasives, chelants including silica, binders and thickening agents, detergents, adhesion agents, foam modulators, pH modifying agents, mouth-feel agents, sweeteners, flavoring agents, colorants, preservatives, combinations thereof, and the like.

[0064] In some embodiments, the oral care composition may further include a surfactant. In some embodiments of the present disclosure, the surfactant may be an anionic surfactant, a non-ionic surfactant or a combination thereof. In some embodiments, the surfactant may also include zwitterionic, amphoteric, or cationic surfactants. In some embodiments, the anionic surfactant may be sodium lauryl sulfate, sodium lauryl glucose carboxylate, lauryl glucoside, disodium 2-sulfolaurate, or a combination thereof. In some embodiments, the non-ionic surfactant may include an alkyl polyglucoside, or lauryl glucoside.

[0065] The surfactant may be prepared in a solvent. The solvent may include water, edible polyhydric alcohol such as glycerin, diglycerin, triglycerin, sorbitol, xylitol, butylene glycol, erythritol, polyethylene glycol, propylene glycol, or combinations thereof.

[0066] In some embodiments, the surfactant may include anionic surfactants such as organophosphate, which include alkyl phosphates, alkyl or alkenyl phosphate esters. The organophospate surfactant has a strong affinity for enamel surface and sufficient surface binding propensity to desorb pellicle proteins and remain affixed to enamel surfaces. Examples of suitable surfactants include alkyl and alkyl (poly)alkoxy phosphates such as lauryl phosphate; PPG5 ceteareth-10 phosphate; Laureth-1 phosphate; Laureth-3 phosphate; Laureth-9 phosphate; Trilaureth-4 phosphate; C12-C18 PEG 9 phosphate; Sodium dilaureth-10phosphate. In one example, the alkyl phosphate is polymeric. Examples of polymeric alkyl phosphates include those containing repeating alkoxy groups as the polymeric portion, in particular 3 or more ethoxy, propoxy, isopropoxy or butoxy groups.

[0067] Zwitterionic or amphoteric surfactants may include derivatives of aliphatic quaternary ammonium, phosphonium, and sulfonium compounds, in which the aliphatic radicals can be straight chain or branched, and wherein one of the aliphatic substituents contains from about 8 to 18 carbon atoms and one contains an anionic water-solubilizing group, such as carboxy, sulfonate, sulfate, phosphate or phosphonate. Amphoteric surfactants may include amine oxide surfactants.

[0068] Additional suitable polymeric organophosphates may include dextran phosphate, poly glucoside phosphate, alkyl polyglucoside phosphate, polyglyceryl phosphate, alkyl polyglyceryl phosphate, polyether phosphates and alkoxylated polyol phosphates. Some examples include polyethylene glycol (PEG) PEG phosphate, polypropylene glycol (PPG) phosphate, alkyl PPG phosphate, PEG / PPG phosphate, alkyl PEG / PPG phosphate, PEG / PPG / PEG phosphate, dipropylene glycol phosphate, PEG glyceryl phosphate, polybutylene glycol (PBG) phosphate, PEG cyclodextrin phosphate, PEG sorbitan phosphate, PEG alkyl sorbitan phosphate, and PEG methyl glucoside phosphate. Suitable non-polymeric phosphates include alkyl mono glyceride phosphate, alkyl sorbitan phosphate, alkyl methyl glucoside phosphate, and alkyl sucrose phosphates.

[0069] In some embodiments, the oral care composition may further include an abrasive. The abrasive may include silica, such as a gel or precipitate, alumina, phosphates including orthophosphates, polymetaphosphates, pyrophosphates, or combinations thereof. Specific example may include silicone microspheres such as polyorganosilsequioxane particles, dicalcium orthophosphate dihydrate, calcium pyrophosphate, tricalcium phosphate, calcium polymetaphosphate, insoluble sodium polymetaphosphate, rice hull silica, hydrated alumina, beta calcium pyrophosphate, calcium carbonate, and resinous abrasive materials such as particulate condensation products of urea and formaldehye. In some embodiments, the abrasive may be silica, polyorganoosilsquioxane, calcium pyrophosphate, poly(methyl methacrylate), calcium carbonate, dicalcium phosphate, barium sulfate or combinations thereof. In some embodiments, the silica may be hydrated silica.

[0070] In some embodiments, the amount of abrasive included in the oral care composition may be about 20 wt% based on the total weight of the oral care composition. In some embodiments, the amount of abrasive included may be about 10 wt% to about 30 wt%, about 12 wt% to about 28 wt%, about 15 wt% to about 25 wt%, or about 17 wt% to about 22 wt%, based on total weight of the oral care composition.

[0071] In other embodiments, the oral care composition may also include at least one ingredient from the group consisting of desensitizing agents, chelating agents, whitening agents, tartar controlagents, detergents, adhesion agents, foam modulators, pH modifying agents, mouth-feel agents, sweeteners, flavoring agents, colorants, preservatives, humectant and combinations thereof.

[0072] In some embodiments, the oral care composition may include a flavoring agent. The flavoring agent is a member chosen from: mucous membrane cooling agents, mucous membrane warming agents, sharptasting substances, sweeteners, sugar substitutes, organic or inorganic acidifiers (e.g., malic acid, acetic acid, citric acid, tartaric acid, phosphoric acid), bitter principles (e.g., quinine, caffeine, limonine, amarogentine, humolones, lupolones, catechols, tannins), edible mineral salts (e.g., sodium chloride, potassium chloride, magnesium chloride and sodium phosphates), essential oils (e.g., oils of spearmint, peppermint, wintergreen, sassafras, clove, sage, eucalyptus, marjoram, cinnamon, lemon, lime, grapefruit, and orange), menthol, carvone, anethole, and combinations thereof.

[0073] Anti -microbial agents may include nonionic antibacterial agents, including halogenated diphenyl ether compounds such as 2,4,4'-trichloro-2'- hydroxydiphenyl ether (Triclosan) and 2,2'-dihydroxy-5,5'- dibromodiphenyl ether. Other useful nonionic antibacterial agents may include phenolic compounds including phenol and its homologs, mono and polyalkyl and aromatic halophenols, resorcinol and its derivatives and bisphenolic compounds, such phenolic compounds being more fully disclosed in U.S. Pat. No. 5,368,844, the disclosure of which is incorporated herein by reference.

[0074] In some embodiments, an oral care composition in accordance with the present disclosure includes an anti-microbial agent. In some embodiments, the anti-microbial agent is a member chosen from: triclosan, chlorhexidine and its salts (e.g., its acetate, gluconate or hydrochloride), peroxides, phenols and their salts, domiphen bromide (phenododecinium bromide), bromochlorophene, Zn salts, stannous fluoride, chlorophylls, Cu salts, Cu gluconate, Cu chlorophyll, sodium lauryl sulfate, polylysine, quarternary monoammonium salts such as cocoaliphaticbenzyldimethylammonium chloride, homopolymers of arginine, arginine salts or complexes, or also pyridinium salts such as cetyl pyridinium chloride, and combinations thereof.

[0075] Thymol, menthol, methyl salicylate and eucalyptol and mixtures thereof are well known as antimicrobials and active against plaque.

[0076] In some embodiments, the anti-microbial agent is a nonionic antibacterial agent. In some embodiments, the nonionic antibacterial agent is included in a oral care composition at a concentration of about 0.001 wt. % to about 5 wt. %. In some embodiments, the nonionic antibacterial agent is present in an amount of about 0.01 wt. % to about 1.5 wt. %.

[0077] Anti-microbial agents of particular interest are quarternary monoammonium salts such as cocoaliphaticbenzyldimethylammonium chloride or also pyridinium salts such as cetyl pyridinium chloride, polylysine, thymol, menthol, methyl salicylate and eucalyptol triclosan, chlorhexidine and its salts (e.g., its acetate, gluconate or hydrochloride) and combinations thereof.

[0078] In some embodiments, an oral care composition may include an anti-caries agent. In some embodiments, the anti-caries agent is a fluoride ion source chosen from: inorganic fluoride salts, such as soluble alkali metal, alkaline earth metal salts (e.g., sodium fluoride, stannous fluoride, potassium fluoride, ammonium fluoride, calcium fluoride), a copper fluoride such as cuprous fluoride, zinc fluoride, barium fluoride, sodium fluorosilicate, ammonium fluorosilicate, sodium fluorozirconate, ammonium fluorozirconate, sodium monofluorphosphate, aluminum mono- and di- fluorophosphate, fluorinated sodium calcium pyrophosphate, and combinations thereof.

[0079] In some embodiments, an oral care composition may include an anti-tartar agent. In some embodiments, the anti -tartar agent is chosen from: pyrophosphate salts including dialkali or tetraalkali metal pyrophosphate salts such as Na4P207, K4P207, Na2K2P207, Na2H2P207 and K2H2P2O7, sodium tripolyphosphate; long chain polyphosphates such as sodium hexametaphosphate; and cyclic phosphates such as sodium trimetaphosphate. In some embodiments, an anti-tartar agent is present in an oral care composition at a concentration of about 1 wt. % to about 5 wt. %.

[0080] In some embodiments, the oral care composition may further contain desensitizing agents. For example, nitrate salts, a bicarbonate salts, potassium nitrate, arg / n / ne-bicarbonate-phytate complex, potassium citrate or oxalate and arginine.

[0081] In some embodiments, an oral care composition may include a thickening agent. In some embodiments, the thickener is selected from the group consisting of, but not limited to: calcium carbonate, titanium dioxide, silicon dioxide, talcum, aluminium oxide, dicalcium phosphate, tricalcium phosphate, magnesium hydroxide, cellulose thickeners such as carboxymethyl cellulose, hyroxyalkyl celluloses such as hydroxypropyl cellulose hydroxyethyl cellulose, polyglycols and polyethylene glycol, inorganic thickeners (e.g., amorphous silica compounds, natural and synthetic clays, lithium magnesium silicate and magnesium aluminum silicate), and combinations thereof.

[0082] In some embodiments, the thickening agent is an organic thickener chosen from: colloids including cellulose thickeners such as carboxymethyl cellulose; hyroxyalkyl celluloses such as hydroxypropyl cellulose hydroxyethyl cellulose; polyglycols of varying molecular weights sold under the tradename Polyox.TM.; and polyethylene glycol. In some embodiments, the thickening agent is an inorganic thickener chosen from: amorphous silica compounds such as colloidal silicas compounds available under the trade designation Cab-o-Sil® (manufactured by Cabot Corporation and distributed by Lenape Chemical, Bound Brook, N.J.); Zeodent® 165 (J.M. Huber Chemicals Division, Havre de Grace, Md. 21078); Sylodent® 15 (Davison Chemical Division of W.R. Grace Corporation, Baltimore, Md. 21203); natural and synthetic clays; lithium magnesium silicate (Laponite); and magnesium aluminum silicate (Veegum). In some embodiments, the thickening agent is present in an oral care composition in amounts of about 0. 1 wt. % to about 10 wt. %. In some embodiments, the thickening agent is present in anamount of about 0.5 wt. % to about 4.0 wt. %.

[0083] In some embodiments, an oral care composition may include an antioxidant. In some embodiments, the anti-oxidant is chosen from: naturally occurring tocopherols and their derivatives (e.g., Vitamin E acetate), Vitamin C and its salts and derivatives (e.g., ascorbyl palmitate, Mg ascorbyl phosphate, ascorbyl acetate), Vitamin A and derivatives (Vitamin A palmitate), tocotrienols, flavonoids, alpha-hydroxy acids (e.g., citric acid, lactic acid, malic acid, tartaric acid) and their Na, Ka and Ca salts, flavonoids, quercetin, phenolic benzylamines, propyl gallate, octyl gallate, dodecyl gallate, butylhydroxyanisole (BHA, E320), butylhydroxytoluene (BHT, 2,6-di-tert.- butyl -4-methylphenol, E321 ), lecithins, mono- and diglycerides of edible fatty acids esterified with citric acid, carotenoids, carotenes (e.g.,o carotene, [3- carotene, lycopene) and their derivatives, phytic acid, lactoferrin, EDTA, EGTA), folic acid and its derivatives, ubiquinone and ubiquinol and their derivatives, ferulic acid and its derivatives, zinc and its derivatives (e.g., ZnO, ZnS04), selenium and its derivatives (e.g., selenium methionine), orthophosphates and Na, K and Ca salts of mono- phosphoric acids, and constituents, extracts and fractions thereof isolated from plants, (e.g., tea, green tea, algae, grapeseeds, wheat germ, chamomile, rosemary, oregano), and combinations thereof.

[0084] Light stabilizers may also be included in the oral care compositions. A good example of a Benzotriazole light stabilizers is 2-(5-chloro-2H-benzotriazol-2-yl)-6-(l , 1 dimethylethyl)-4-methyl phenol.

[0085] The oral care composition of the present disclosure may be a product selected from the group consisting of toothpastes, oral gel, or liquid paste.

[0086] In an embodiment of the present disclosure, a method for cleaning is also provided. The method includes applying an oral care composition as described herein to a surface of a mammalian tooth.EXAMPLES

[0087] The present invention will now be more fully described with reference to the accompanying examples. It should be understood, however, that the following description is illustrative only and should not be taken in any way as a restriction of the invention.Rheology Study

[0088] A study was conducted to compare the rheology of different thickening polymers in the oral care composition. This study was conducted to understand the rheology profile difference of tara gum, glucomannan and alginate when compared to xanthan gum. To perform this study, simple solutions of the gums were made by adding 1% of the gum to 19% of glycerin, which was mixed well before adding to DI water. For the alginate sample, 0.01% of CaC12 powder was added to the DI water before adding the gummixture, which was found to help reach the target viscosity. The rheology of these gels was analyzed using a TA instrument HR rheometer.

[0089] As shown in Figure 1, the sample containing xanthan gum held a stead viscosity at low shear stress, and then sharply dropped after high shear stress. The sample including glucomannan appeared to have similar viscosity at the lower end of shear stress but started to drop at a less steep rate earlier than the xanthan gum sample. The sample with tara gum had a lower viscosity when compared to xanthan gum and glucomannan, but the tara gum sample exhibited higher viscosity than them at high shear stress. The unique behavior of the tara gum sample enables a late and smooth breaking of the polymer structure, where the xanthan gum sample showed an earlier and abrupt breaking. The sample including carrageenan had the lowest viscosity among all the samples. The sample including alginate demonstrated a unique profile where higher viscosity was only detected at high shear stress. Because of the unique viscosity profiles of these gums, the present inventors found that combinations of the gums created new formula textures.Adhesion and Cohesion Study

[0090] The Samples prepared for the rheology study discussed above, were further tested to study the adhesion and cohesion properties. Adhesion is also referred to loss modulus of the composition, and cohesion is also referred to as storage modulus. Both of these properties are important for application of the oral care composition. A higher adhesion indicates the potential of better mouth coating and delivery of an active agent to the oral surface, while cohesion suggests better structure integrity of the composition.

[0091] As can be seen in Figures 2 and 3, the sample of tara gum had lower storage modulus and higher loss modulus, indicating better spreadability than xanthan gum. The glucomannan sample had similar storage modulus and higher loss modulus which outlined better coating effect than xanthan gum. The sample including alginate had both higher adhesion and cohesion when compared to xanthan gum, implying better gel structure and coating effect to oral surfaces. The sample including carrageenan on the other hand showed lower adhesion and cohesion when compared to xanthan gum, indicating a weaker gel structure that can spread easily.Example 1

[0092] An oral care composition in accordance with the present disclosure was prepared. The oral care composition was prepared including both xanthan gum and tara gum was to show the effect of the combination of thickening polymers. The viscosity profile of this composition was studied with the rheometer and compared with a marketed benchmark toothpaste (Aquafresh Extreme Clean), which utilizes only xanthan gum as a thickener.Table 1 Oral Care Composition Formulation including 0.5% Xanthan Gum and 0.25% Tara Gum

[0093] As can been seen in Figure 4, the composition of the present disclosure held a similar viscosity profile as the benchmark toothpaste, where they both maintained higher viscosity at low shear stress then significantly dropped as shear stress increased. This viscosity profile enables a unique property of the oral care composition, where the oral care composition holds shape when being placed on a toothbrush but then rapidly dissociates during brushing. When compared to the benchmark formulation, the sample of the present disclosure dissociates / breaks up at a lower shear stress.

[0094] In terms of stringiness, a demonstration was designed to showcase the stringiness difference between the sample and benchmark. The bottom of a glass beaker was pressed against the samples and was then pulled up. As can be seen in Figure 5, the benchmark composition (on left side) pulls out significant longer string when compared to the composition of the present disclosure. Thus, the usage of tara gum in combination with xanthan gum significantly reduced the stringiness of a toothpaste prepared with xanthan gum alone.Examples 2 to 7

[0095] An oral care compositions in accordance with the present disclosure were prepared with xanthan gum, tar a gum, glucomannan, and algin to show the effect of the combination of thickening polymers. The viscosity profile of this composition was studied with the rheometer and compared with a marketed benchmark toothpaste (Aquafresh Extreme Clean), which utilizes only xanthan gum as a thickener.Table 2 Oral Care Composition Formulation having Tara Gum With Another Thickeniung PolymerTable 3 Oral Care Composition Formulation having Xanthan Gum With Another Thickening PolymerConsumer Panel

[0096] A small consumer panel was also conducted to evaluate the sample composition compared to the benchmark in view of the consumer perspective. Ten selected panelists familiar with sensory testing evaluations were given the sample composition of Table 1 and the benchmark toothpaste containing only xanthan gum. The compositions were given in random order. The sensory evaluation results of the consumer panel are presented in Figure 6. When rated in pairwise comparison, the sample of Table 1 was rated as exhibiting more foaminess. While other parameters, particularly clean feel after brushing and overall preference seem to trend higher for the examples, the differences are not statistically significant. On the other hand, toothpaste standup was another important attribute to the consumer experience. Morepanelist favored the standup / shape of the composition of Table 1 verse the benchmark.

[0097] Thus, preparing a composition including xanthan gum and an additional thickening polymer built structure to the formula while offering different rheology profiles when compared to oral care compositions including only xanthan gum. Based on these tests, the present inventors theorize that the addition of tara gum, glucomannan and / or alginate have the potential to provide positive attributes to oral care composition, like standup, foaminess and clean feel after brushing.

[0098] The dimensions and values disclosed herein are not to be understood as being strictly limited to the exact numerical values recited. Instead, unless otherwise specified, each such dimension is intended to mean both the recited value and a functionally equivalent range surrounding that value. For example, a value disclosed as “5 wt%” is intended to mean “about 5 wt% ”

[0099] While particular embodiments of the present invention have been illustrated and described, it would be obvious to those skilled in the art that various other changes and modifications can be made without departing from the spirit and scope of the invention. It is therefore intended to cover in the appended claims all such changes and modifications that are within the scope of this invention.

Claims

WHAT IS CLAIMED IS:

1. An oral care composition comprising: at least two thickening polymers selected from xanthan gum, tara gum, glucomannan, carrageenan, and algin; and glycerin, wherein the oral care composition has a viscosity of about 0. 1 to about 1000 Pa s.

2. The oral care composition of claim 1, wherein the composition has a storage modulus of about 1 Pa to about 1000 Pa.

3. The oral care composition of claim 1, wherein the composition has a loss modulus of about 10 Pa to about 1000 Pa.

4. The oral care composition of any of the preceding claims, wherein the composition further comprises an emulsifier.

5. The oral care composition of claim 4, wherein the emulsifier comprises stearyl alcohol, cetearyl alcohol, cetyl alcohol, sodium lauryl sulfate, sodium lauryl glucose carboxylate, lauryl glucoside, or a combination thereof.

6. The oral care composition of claim 1, wherein the at least two thickening polymers include xanthan gum in an amount of about 0. 1 wt% to about 10 wt%, based on total weight of the composition.

7. The oral care composition of claim 1, wherein the at least two thickening polymers include tara gum in an amount of about 0. 1 wt% to about 10 wt%, based on total weight of the composition.

8. The oral care composition of claim 1, wherein the at least two thickening polymers include glucomannan in an amount of about 0. 1 wt% to about 10 wt%, based on total weight of the composition.

9. The oral care composition of claim 1, wherein the at least two thickening polymers include carrageenan in an amount of about 0. 1 wt% to about 10 wt%, based on total weight of the composition.

10. The oral care composition of claim 1, wherein the at least two thickening polymers include algin in an amount of about 0.1 wt% to about 10 wt%, based on total weight of the composition.

11. The oral care composition of claim 1, wherein the at least two thickening polymers includes xanthan gum and tara gum.

12. The oral care composition of any one of claims 1-11, wherein the composition further comprises sorbitol.

13. The oral care composition of claim 12, wherein the sorbitol is included in an amount of about 20 wt% to about 60 wt%, based on total weight of the composition.

14. The oral care composition of any one of claims 1-11, wherein the composition further comprises an antioxidant.

15. The oral care composition of claim 14, wherein the antioxidant comprises panthenol, ascorbic acid, tocopherol, or a combination thereof.

16. The oral care composition of any one of claims 1-11, wherein the composition further comprises sodium fluoride, sodium benzoate, sodium saccharin, or a combination thereof.

17. The oral care composition of any one of claims 1-16, wherein the composition further comprises at least one ingredient selected from the group consisting of desensitizing agents, chelating agents, whitening agents, tartar control agents, detergents, adhesion agents, an abrasive, foam modulators, pH modifying agents, mouth-feel agents, sweeteners, flavoring agents, colorants, preservatives, humectant, or a combination thereof.

18. The oral care composition of claim 1, wherein the composition further comprises an abrasive.

19. The oral care composition of claim 18, wherein the abrasive comprises silica, polyorganosileequioxane, calcium pyrophosphate, poly(methyl methacrylate), calcium carbonate, dicalcium phosphate, barium sulfate, or a combination thereof.

20. The oral care composition of claim 19, wherein the silica is hydrated silica.

21. The oral care composition of claim 1, wherein the composition further comprises a surfactant.

22. The oral care composition of claim 21, wherein the surfactant comprises sodium lauryl glucose carboxylate, lauryl glucoside, coco glucoside, decyl glucoside, capylyl / capyl glucoside, sodium cocyl glutamate, potassium cocoyl glycinate, disodium 2-sulfolaurate, or a combination thereof.

23. The oral care composition of claim 1, wherein the composition is a product selected from an oral gel or a liquid paste.

24. A method of cleaning comprising applying to a surface of a mammalian tooth the oral care composition according to one of claims 1-23.

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