Sensitive-skin Anti-acne repairing composition containing guaiacum officinale extract and preparation method therefor

Abstract

A sensitive-skin anti-acne repairing composition containing a Guaiacum officinale extract and a preparation method therefor. The present invention pertains to the technical field of cosmetics. The composition comprises: a Guaiacum officinale extract, an Isatidis folium extract, a chamomile extract, the antimicrobial peptide LL-37, acetyl tetrapeptide-40, modified palmitoyl tripeptide-8, and modified acetyl hexapeptide-49. The surface of the modified palmitoyl tripeptide-8 and the surface of the modified acetyl hexapeptide-49 are coated with the Guaiacum officinale extract and Sethic G57. The composition uses the plant extract and the antimicrobial peptide to inhibit bacteria and resist inflammation and uses the anti-allergy peptide and the repair peptide to repair the skin barrier, achieving a good effect of repairing acne-prone and sensitive skin without recurrence. In addition, the composition is mild and not irritating. Particularly, the anti-allergy peptide and the repair peptide are modified, so that the composition can soothe the skin, resist allergy, increase the skin's tolerance threshold, and reduce skin discomforts such as various irritations and pain.

Description

A sensitive skin acne-repairing composition containing guaiac extract and preparation method thereof Technical Field

[0001] The present invention belongs to the technical field of cosmetics, and in particular relates to a sensitive skin acne-repairing composition containing a guaiac extract and a preparation method thereof. Background Art

[0002] Acne-sensitive skin refers to acne-prone skin combined with sensitive skin. Common manifestations of acne-sensitive skin include facial acne, red papules, nodules, cysts, and other acne-prone rashes, accompanied by allergic rashes such as redness, dilated capillaries, and scaling. In our daily lives, we often consume foods with harmful additives, stay up late, get angry, use inappropriate cosmetics, suffer from medication side effects, hormonal imbalances, and a deteriorating natural environment. These factors can all contribute to acne and lead to the development of acne-sensitive skin.

[0003] When acne-sensitive skin is stimulated by mental, physical, chemical and other factors, the face will experience bursts of burning, redness, itching, tightness, and even pain. Acne-sensitive skin is difficult to eradicate and cure. Skin sensitivity and acne affect each other, making skin repair more difficult.

[0004] Currently, there are relatively few products on the market specifically designed to repair acne-prone skin. Typical acne-removing products focus on oil control and killing Propionibacterium acnes. Antibacterial skincare products can be highly irritating to already acne-prone skin and have side effects on sensitive skin. Therefore, acne-prone skin requires soothing and anti-allergic treatments before acne treatment to achieve a complete cure. However, current acne-repair products still lack effective results.

[0005] Summary of the Invention

[0006] The problem that most acne removal products on the market are antibacterial and sterilizing, while the repair effect of acne-sensitive skin is not ideal is addressed by these acne removal products. The present invention provides a sensitive skin acne repairing composition containing guaiac extract and a preparation method thereof, which uses plant extracts and antimicrobial peptides to inhibit bacteria and inflammation, and uses anti-sensitive peptides and repair peptides to repair the skin barrier, thereby achieving a good effect of repairing acne-sensitive skin without recurrence, and being mild and non-irritating; in particular, the anti-sensitive peptides and repair peptides are modified to be soothing and anti-allergic, and to increase the skin's tolerance threshold, thereby reducing the skin's discomfort to various stimuli, pain, etc., and during use, the mild ingredients will not cause serious irritation, thus preventing skin absorption disorders and preventing new inflammation. The specific technical scheme is as follows:

[0007] A guaiac extract-containing acne-sensitive skin repair composition comprises, by weight, 3 to 6 parts of guaiac extract, 0.5 to 1 part of isatis indigotica extract, 2 to 4 parts of chamomile extract, 0.5 to 2 parts of antimicrobial peptide LL-37, 1 to 3 parts of acetyl tetrapeptide-40, 1 to 3 parts of modified palmitoyl tripeptide-8, and 1 to 3 parts of modified acetyl hexapeptide-49; the surfaces of the modified palmitoyl tripeptide-8 and the modified acetyl hexapeptide-49 are coated with guaiac extract and Senting G57; the composition further comprises 0.5 to 1 part of a thickener, 0.5 to 1 part of an emulsifier, 1 to 1.5 parts of a penetrant, 2 to 5 parts of a moisturizer, and 4 to 10 parts of purified water.

[0008] In the above technical solution, the guaiac extract, the isatis leaf extract and the chamomile extract are ethanol extracts.

[0009] In the above technical solution, the thickener is one or more combinations of xanthan gum, carbomer and acrylic acid copolymer.

[0010] In the above technical solution, the emulsifier is one or more combinations of poloxamer, lecithin and Tween 80.

[0011] In the above technical solution, the penetrant is an alkyl glycoside.

[0012] In the above technical solution, the moisturizer is one or more combinations of glycerin, propylene glycol, butylene glycol, and ceramide.

[0013] The preparation method of the acne-sensitive skin repairing composition containing guaiac extract comprises the following steps:

[0014] Step 1: freeze-dry palmitoyl tripeptide-8 with liquid nitrogen, then add it to an ethanol solution containing guaiac extract and Santing G57, stir evenly, and vacuum dry to remove ethanol and water to obtain modified palmitoyl tripeptide-8;

[0015] Step 2: lyophilize acetyl hexapeptide-49 with liquid nitrogen, then add it to an ethanol solution containing guaiac extract and Santing G57, stir evenly, and vacuum dry to remove ethanol and water to obtain modified acetyl hexapeptide-49;

[0016] Step 3: First, according to the mass ratio, the purified water, thickener, emulsifier, penetrant and moisturizer are mixed uniformly at 80°C to 85°C, and then cooled to 50°C to 55°C, and then the guaiac extract, the isatis leaf extract and the chamomile extract are added and mixed uniformly, and then cooled to 38°C to 41°C, and the antimicrobial peptide LL-37 and acetyl tetrapeptide-40 are added and mixed uniformly, and finally, the modified palmitoyl tripeptide-8 and the modified acetyl hexapeptide-49 are added and stirred at a low speed to obtain a composition.

[0017] In step 1 of the above preparation method, the ethanol solution containing guaiac extract and Santing G57 is water: ethanol: guaiac extract: Santing G57 = (60-80): (20-30): (20-25): (10-15); the liquid nitrogen freeze-drying time is 20 min to 40 min; the low-temperature stirring time is 30 s to 60 s, and the temperature is 5°C to 10°C; the vacuum degree of vacuum drying is 0.2 MPa to 0.3 MPa, and the temperature is 38°C to 40°C.

[0018] In step 2 of the above preparation method, the ethanol solution containing guaiac extract and Cinnamomum camphora G57 is as follows: water:ethanol:guaiac extract:Cinnamomum camphora G57=(60-80):(20-30):(20-25):(10-15); the liquid nitrogen freeze-drying time is 20 min to 40 min; the low-temperature stirring time is 30 s to 60 s, and the temperature is 5°C to 10°C; the vacuum degree of vacuum drying is 0.2 MPa to 0.3 MPa, and the temperature is 38°C to 40°C.

[0019] In step 3 of the above preparation method, the low-speed mixing speed is 12 rpm to 14 rpm, and the time is 2 min to 3 min.

[0020] Compared with the prior art, the sensitive skin acne-repairing composition containing guaiac extract of the present invention and its preparation method have the following beneficial effects:

[0021] 1. The composition of the present invention is added with the ethanol extract of Guaiac wood, which has the bactericidal and antiviral effects of the Guaiac wood extract, can reduce inflammation caused by harmful bacteria on the skin and reduce the occurrence of new acne.

[0022] 2. The composition of the present invention is added with the ethanol extract of Folium Isatidis, which has a good anti-inflammatory effect. When used in combination with the extract of Guaiac, it can inhibit the inflammation caused by bacteria.

[0023] 3. The composition of the present invention is added with ethanol extract of chamomile, which has a good anti-allergic effect, can improve blood vessel rupture, effectively repair blood vessel walls, restore and enhance blood vessel elasticity, improve the sensitivity of facial skin to stimuli, and relieve skin allergies.

[0024] Fourth, the composition of the present invention contains the antimicrobial peptide LL-37, which has antimicrobial effects and activates TLR3 to induce angiogenesis, thereby repairing necrotic capillaries. However, the antimicrobial peptide LL-37 also has the side effect of causing inflammation. Therefore, the composition of the present invention also contains acetyl tetrapeptide-40 at a higher dose than the antimicrobial peptide LL-37. Acetyl tetrapeptide-40 can inhibit the inflammatory response caused by the antimicrobial peptide LL-37, reduce the release of interleukins IL-6 and IL-8, reduce cell damage and skin inflammatory damage, and reduce facial redness, swelling, and capillary dilation caused by inflammation.

[0025] Fifth, the composition of the present invention contains palmitoyl tripeptide-8, which has a soothing and anti-allergic effect. Palmitoyl tripeptide-8 has an affinity similar to that of α-MSH and readily binds to MC1-R, while exhibiting only weak melanin activity. In keratinocytes, palmitoyl tripeptide-8 effectively reduces UVB-induced inflammatory mediators by binding to and activating the MC1-R receptor. Furthermore, palmitoyl tripeptide-8 can interfere with the production of TNF-α, preventing neurodermatitis symptoms such as edema and redness.

[0026] 6. The composition of the present invention contains acetyl hexapeptide-49, a peptide that reduces inflammation and relieves itching by inhibiting PAR-2 ​​activity, while also improving cell proliferation and differentiation. Acetyl hexapeptide-49, when used in conjunction with chamomile extract, can repair the skin's blocked stratum corneum, promote its growth, and form the body's own natural barrier, preventing allergies and preventing recurrence.

[0027] 7. Sensitive skin is characterized by impaired skin barrier function, increased transdermal water loss, and enhanced transdermal absorption of chemicals, which allows external irritants to penetrate easily. This leads to enhanced sensory nerve signal transmission in the skin and a lowered tolerance threshold, resulting in an overreaction to even mild irritants in cosmetics. The present invention modifies palmitoyl tripeptide-8 and acetyl hexapeptide-49, and the surfaces of the modified palmitoyl tripeptide-8 and modified acetyl hexapeptide-49 are coated with guaiac extract and Sentin G57. On the one hand, the coating of Senting G57 has a sustained-release effect on palmitoyl tripeptide-8 and acetyl hexapeptide-49, delaying their absorption. Each ingredient is absorbed at different times, which does not cause skin absorption disorder, prevents inflammation, and achieves a better soothing and repairing effect. On the other hand, the use of guaiac extract combined with palmitoyl tripeptide-8 and acetyl hexapeptide-49 for absorption can achieve long-lasting antibacterial effect without deterioration or inflammation. After the ingredients are absorbed, they can gently repair the skin to form a natural anti-allergic barrier, which can increase the skin's tolerance threshold and reduce the skin's discomfort such as various irritations and pain. Moreover, during use, the mild ingredients will not cause severe irritation. DETAILED DESCRIPTION

[0028] The present invention will be further described below with reference to specific implementation cases, but the present invention is not limited to these embodiments.

[0029] Example 1

[0030] A acne-sensitive skin repairing composition containing guaiac extract, comprising the following components by weight: 5 parts of guaiac extract, 0.8 parts of isatis indigotica extract, 3 parts of chamomile extract, 1 part of antimicrobial peptide LL-37, 2 parts of acetyl tetrapeptide-40, 2 parts of modified palmitoyl tripeptide-8, and 2 parts of modified acetyl hexapeptide-49; the surfaces of the modified palmitoyl tripeptide-8 and the modified acetyl hexapeptide-49 are coated with guaiac extract and Senting G57; the composition also comprises 0.8 parts of a thickener, 0.8 parts of an emulsifier, 1.2 parts of a penetrant, 3 parts of a moisturizer, and 5 parts of purified water.

[0031] Among them, the guaiac extract, the isatis leaf extract and the chamomile extract are ethanol extracts.

[0032] In the composition of this embodiment, the thickener is carbomer. The emulsifier is Tween 80. The penetrant is an alkyl glycoside. The humectant is a combination of glycerin, butylene glycol, and ceramide, with a mass ratio of glycerin:butylene glycol:ceramide = 3:1:3.

[0033] The preparation method of the acne-sensitive skin repairing composition containing guaiac extract comprises the following steps:

[0034] Step 1: Palmitoyl tripeptide-8 was freeze-dried in liquid nitrogen for 30 minutes, and then palmitoyl tripeptide-8 was added to an ethanol solution containing guaiac extract and cinting G57 at a mass ratio of 1:1. After stirring at 8°C for 40 seconds, the ethanol and water were removed by vacuum drying at a vacuum degree of 0.25 MPa and a temperature of 39°C to obtain modified palmitoyl tripeptide-8;

[0035] Among them, in the ethanol solution containing guaiac extract and Cinnamomum camphora G57, the ratio of water:ethanol:guaiac extract:Cinnamomum camphora G57 is 70:25:23:12.

[0036] Step 2: Acetyl hexapeptide-49 was freeze-dried with liquid nitrogen for 30 minutes, and then acetyl hexapeptide-49 was added to an ethanol solution containing guaiac extract and cinting G57 at a mass ratio of 1:1, stirred at 8°C for 40 seconds, and then vacuum-dried to remove ethanol and water under vacuum conditions of 0.25 MPa and 39°C to obtain modified acetyl hexapeptide-49;

[0037] Among them, in the ethanol solution containing guaiac extract and Cinnamomum camphora G57, the ratio of water:ethanol:guaiac extract:Cinnamomum camphora G57 is 70:25:23:12.

[0038] Step 3: First, according to the mass ratio, the purified water, thickener, emulsifier, penetrant and moisturizer were mixed uniformly at 83 ° C, and then cooled to 52 ° C, and the guaiac extract, isatis leaf extract and chamomile extract were added and mixed uniformly, and then cooled to 40 ° C, and the antimicrobial peptide LL-37 and acetyl tetrapeptide-40 were added and mixed uniformly, and finally, modified palmitoyl tripeptide-8 and modified acetyl hexapeptide-49 were added and stirred at a low speed of 12 rpm for 2 min to obtain a composition.

[0039] Preparation of the composition of Comparative Example 1: Palmitoyl tripeptide-8 and acetyl hexapeptide-49 were not modified, and palmitoyl tripeptide-8 and acetyl hexapeptide-49 were directly added. Other parameters were the same as those in this example.

[0040] The composition of Comparative Example 2 was prepared without adding acetyl tetrapeptide-40, and other parameters were the same as those of this embodiment.

[0041] The composition of Comparative Example 3 was prepared: no guaiac extract was added, and no guaiac extract was added to the modified palmitoyl tripeptide-8 and the modified acetyl hexapeptide-49. Other parameters were the same as those in this example.

[0042] The compositions of this example, comparative example 1, comparative example 2 and comparative example 3 were tested.

[0043] 1. Safety tests were conducted on the compositions of this embodiment, comparative example 1, comparative example 2, and comparative example 3 respectively according to conventional testing methods. The raw materials of the compositions are all raw materials allowed to be added to cosmetics and are safe and non-toxic.

[0044] 2. Experiment on the repair effect of acne-sensitive skin:

[0045] 40 subjects with acne-sensitive skin who were positive for lactic acid stinging were selected and randomly divided into 4 groups, with 10 subjects in each group. The subjects were treated with the composition of this example, the composition of comparative example 1, the composition of comparative example 2, and the composition of comparative example 3, respectively. The compositions were applied to the face once in the morning and once in the evening, and the repair effects on acne-sensitive skin were observed and tested. The results are shown in the following table:

[0046] As can be seen from the experimental results, the composition of the present embodiment has a good effect on repairing acne-sensitive muscle. After 7 days of use, there is no pain sensation, and the anti-allergic effect is very good. The anti-allergic effect of the composition of Comparative Example 1 is slightly worse. After 7 days of use, there is still a slight stimulation pain sensation, and the acne-sensitive muscle is slowly repaired, indicating that palmitoyl tripeptide-8 and acetyl hexapeptide-49 will affect the repair progress if they are not modified. The composition of Comparative Example 2 is used for 7 days to increase the pain sensation, and there are newly added repeated acne, indicating that the simple addition of antimicrobial peptide LL-37 without acetyl tetrapeptide-40 inhibition has produced certain inflammation. The composition of Comparative Example 3 is used for 7 days and there is still a slight stimulation pain sensation, and there are newly added repeated acne, indicating that the antibacterial property of the guaiac extract is lacking and there is bacterial infection.

[0047] Example 2

[0048] A acne-sensitive skin repairing composition containing guaiac extract, comprising, by weight, 3.5 parts of guaiac extract, 0.6 parts of isatis indigotica extract, 2.5 parts of chamomile extract, 0.8 parts of antimicrobial peptide LL-37, 1.2 parts of acetyl tetrapeptide-40, 1.2 parts of modified palmitoyl tripeptide-8, and 1.2 parts of modified acetyl hexapeptide-49; the surfaces of the modified palmitoyl tripeptide-8 and the modified acetyl hexapeptide-49 are coated with guaiac extract and Senting G57; the composition further comprises 0.6 parts of a thickener, 0.6 parts of an emulsifier, 1.1 parts of a penetrant, 2.5 parts of a moisturizer, and 4.5 parts of purified water.

[0049] Among them, the guaiac extract, the isatis leaf extract and the chamomile extract are ethanol extracts.

[0050] In the composition of this embodiment, the thickener is a combination of xanthan gum and carbomer, with a mass ratio of xanthan gum:carbomer = 1:2. The emulsifier is poloxamer. The penetrant is an alkyl glycoside. The humectant is a combination of glycerin, propylene glycol, and ceramide, with a mass ratio of glycerin:propylene glycol:ceramide = 2:2:3.

[0051] The preparation method of the acne-sensitive skin repairing composition containing guaiac extract comprises the following steps:

[0052] Step 1: Palmitoyl tripeptide-8 was freeze-dried with liquid nitrogen for 25 minutes, and then palmitoyl tripeptide-8 was added to an ethanol solution containing guaiac extract and cinting G57 at a mass ratio of 1:1. After stirring at 6°C for 35 seconds, the ethanol and water were removed by vacuum drying at a vacuum degree of 0.2 MPa and a temperature of 38.2°C to obtain modified palmitoyl tripeptide-8;

[0053] Among them, in the ethanol solution containing guaiac extract and Cinnamomum camphora G57, the ratio of water:ethanol:guaiac extract:Cinnamomum camphora G57 is 65:22:21:11.

[0054] Step 2: Acetyl hexapeptide-49 was freeze-dried with liquid nitrogen for 25 minutes, and then acetyl hexapeptide-49 was added to an ethanol solution containing guaiac extract and cinting G57 at a mass ratio of 1:1, stirred at 6°C for 35 seconds, and then vacuum-dried to remove ethanol and water under vacuum conditions of 0.2 MPa and 38.2°C to obtain modified acetyl hexapeptide-49;

[0055] Among them, in the ethanol solution containing guaiac extract and Cinnamomum camphora G57, the ratio of water:ethanol:guaiac extract:Cinnamomum camphora G57 is 65:22:21:11.

[0056] Step 3: First, according to the mass ratio, the purified water, thickener, emulsifier, penetrant and moisturizer were mixed uniformly at 81 ° C, and then cooled to 51 ° C, and the guaiac extract, isatis leaf extract and chamomile extract were added and mixed uniformly, and then cooled to 38.5 ° C, and the antibacterial peptide LL-37 and acetyl tetrapeptide-40 were added and mixed uniformly, and finally, modified palmitoyl tripeptide-8 and modified acetyl hexapeptide-49 were added and stirred at a low speed of 12 rpm for 2.5 min to obtain a composition.

[0057] Example 3

[0058] A guaiac extract-containing acne-sensitive skin repair composition comprises, by weight, 5.5 parts of guaiac extract, 0.9 parts of isatis indigotica extract, 3.5 parts of chamomile extract, 1.8 parts of antimicrobial peptide LL-37, 2.5 parts of acetyl tetrapeptide-40, 2.5 parts of modified palmitoyl tripeptide-8, and 2.5 parts of modified acetyl hexapeptide-49; the surfaces of modified palmitoyl tripeptide-8 and modified acetyl hexapeptide-49 are coated with guaiac extract and Senting G57; the composition also comprises 0.9 parts of a thickener, 0.9 parts of an emulsifier, 1.4 parts of a penetrant, 4.5 parts of a moisturizer, and 8 parts of purified water.

[0059] Among them, the guaiac extract, the isatis leaf extract and the chamomile extract are ethanol extracts.

[0060] In the composition of this embodiment, the thickener is a combination of carbomer and acrylic acid copolymer, with a mass ratio of carbomer to acrylic acid copolymer of 2:1.5. The emulsifier is a combination of lecithin and polysorbate 80, with a mass ratio of lecithin to polysorbate 80 of 1:1. The penetrant is an alkyl glycoside. The humectant is a combination of butylene glycol and ceramide, with a mass ratio of butylene glycol to ceramide of 2:1.

[0061] The preparation method of the acne-sensitive skin repairing composition containing guaiac extract comprises the following steps:

[0062] Step 1: Palmitoyl tripeptide-8 was freeze-dried with liquid nitrogen for 35 minutes, and then palmitoyl tripeptide-8 was added to an ethanol solution containing guaiac extract and cinting G57 at a mass ratio of 1:1. After stirring at 9°C for 50 seconds, the mixture was vacuum-dried to remove ethanol and water at a vacuum degree of 0.3 MPa and a temperature of 39.5°C to obtain modified palmitoyl tripeptide-8;

[0063] Among them, in the ethanol solution containing guaiac extract and Cinnamomum camphora G57, the ratio of water:ethanol:guaiac extract:Cinnamomum camphora G57 is 75:28:24:14.

[0064] Step 2: Acetyl hexapeptide-49 was freeze-dried with liquid nitrogen for 35 minutes, and then acetyl hexapeptide-49 was added to an ethanol solution containing guaiac extract and cinting G57 at a mass ratio of 1:1, stirred at 9°C for 50 seconds, and then vacuum-dried to remove ethanol and water under vacuum conditions of 0.3 MPa and 39.5°C to obtain modified acetyl hexapeptide-49;

[0065] Among them, in the ethanol solution containing guaiac extract and Cinnamomum camphora G57, the ratio of water:ethanol:guaiac extract:Cinnamomum camphora G57 is 75:28:24:14.

[0066] Step 3: First, according to the mass ratio, the purified water, thickener, emulsifier, penetrant and moisturizer were mixed uniformly at 84 ° C, and then cooled to 54 ° C, and the guaiac extract, isatis leaf extract and chamomile extract were added and mixed uniformly, and then cooled to 40.5 ° C, and the antimicrobial peptide LL-37 and acetyl tetrapeptide-40 were added and mixed uniformly, and finally, modified palmitoyl tripeptide-8 and modified acetyl hexapeptide-49 were added and stirred at a low speed of 14 rpm for 3 minutes to obtain a composition.

[0067] Example 4

[0068] A guaiac extract-containing acne-sensitive skin repair composition, comprising, by weight, 3 parts of guaiac extract, 1 part of isatis indigo leaf extract, 2 parts of chamomile extract, 2 parts of antimicrobial peptide LL-37, 2.5 parts of acetyl tetrapeptide-40, 3 parts of modified palmitoyl tripeptide-8, and 1 part of modified acetyl hexapeptide-49; the surfaces of modified palmitoyl tripeptide-8 and modified acetyl hexapeptide-49 are coated with guaiac extract and Senting G57; the composition also includes 1 part of a thickener, 0.5 parts of an emulsifier, 1.5 parts of a penetrant, 2 parts of a moisturizer, and 10 parts of purified water.

[0069] Among them, the guaiac extract, the isatis leaf extract and the chamomile extract are ethanol extracts.

[0070] In the composition of this embodiment, the thickener is xanthan gum. The emulsifier is lecithin. The penetrant is an alkyl glycoside. The humectant is a combination of glycerol and butylene glycol, with a mass ratio of glycerol:butylene glycol = 1:1.5.

[0071] The preparation method of the acne-sensitive skin repairing composition containing guaiac extract comprises the following steps:

[0072] Step 1: Palmitoyl tripeptide-8 was freeze-dried with liquid nitrogen for 20 minutes, and then palmitoyl tripeptide-8 was added to an ethanol solution containing guaiac extract and cinting G57 at a mass ratio of 1:1. After stirring at 10°C for 30 seconds, the ethanol and water were removed by vacuum drying at a vacuum degree of 0.3 MPa and a temperature of 38°C to obtain modified palmitoyl tripeptide-8;

[0073] Among them, in the ethanol solution containing guaiac extract and Cinnamomum camphora G57, the ratio of water:ethanol:guaiac extract:Cinnamomum camphora G57 is 80:20:25:10.

[0074] Step 2: Acetyl hexapeptide-49 was freeze-dried with liquid nitrogen for 20 minutes, and then acetyl hexapeptide-49 was added to an ethanol solution containing guaiac extract and cinting G57 at a mass ratio of 1:1. After stirring at 10°C for 30 seconds, the mixture was vacuum-dried to remove ethanol and water at a vacuum degree of 0.3 MPa and a temperature of 38°C to obtain modified acetyl hexapeptide-49;

[0075] Among them, in the ethanol solution containing guaiac extract and Cinnamomum camphora G57, the ratio of water:ethanol:guaiac extract:Cinnamomum camphora G57 is 80:20:25:10.

[0076] Step 3: First, according to the mass ratio, the purified water, thickener, emulsifier, penetrant and moisturizer were mixed uniformly at 85 ° C, and then cooled to 50 ° C, and the guaiac extract, isatis leaf extract and chamomile extract were added and mixed uniformly, and then cooled to 41 ° C, and the antimicrobial peptide LL-37 and acetyl tetrapeptide-40 were added and mixed uniformly, and finally, modified palmitoyl tripeptide-8 and modified acetyl hexapeptide-49 were added and stirred at a low speed of 12 rpm for 3 minutes to obtain a composition.

[0077] Example 5

[0078] A guaiac extract-containing acne-sensitive skin repair composition comprises, by weight, 6 parts of guaiac extract, 0.5 parts of isatis indigo leaf extract, 4 parts of chamomile extract, 0.5 parts of antimicrobial peptide LL-37, 3 parts of acetyl tetrapeptide-40, 1 part of modified palmitoyl tripeptide-8, and 3 parts of modified acetyl hexapeptide-49; the surfaces of modified palmitoyl tripeptide-8 and modified acetyl hexapeptide-49 are coated with guaiac extract and Senting G57; the composition also comprises 0.5 parts of a thickener, 1 part of an emulsifier, 1 part of a penetrant, 5 parts of a moisturizer, and 4 parts of purified water.

[0079] Among them, the guaiac extract, the isatis leaf extract and the chamomile extract are ethanol extracts.

[0080] In the composition of this embodiment, the thickener is a combination of xanthan gum and acrylic acid copolymer, with a mass ratio of xanthan gum:acrylic acid copolymer = 1:2. The emulsifier is a combination of poloxamer and lecithin, with a mass ratio of poloxamer:lecithin = 1:1. The penetrant is an alkyl glycoside. The humectant is a combination of butylene glycol and ceramide, with a mass ratio of butylene glycol:ceramide = 2:1.

[0081] The preparation method of the acne-sensitive skin repairing composition containing guaiac extract comprises the following steps:

[0082] Step 1: Palmitoyl tripeptide-8 was freeze-dried with liquid nitrogen for 40 minutes, and then palmitoyl tripeptide-8 was added to an ethanol solution containing guaiac extract and cinting G57 at a mass ratio of 1:1. After stirring at 5°C for 60 seconds, the ethanol and water were removed by vacuum drying at a vacuum degree of 0.2 MPa and a temperature of 40°C to obtain modified palmitoyl tripeptide-8;

[0083] Among them, in the ethanol solution containing guaiac extract and Cinnamomum camphora G57, the ratio of water:ethanol:guaiac extract:Cinnamomum camphora G57 is 60:30:20:15.

[0084] Step 2: Acetyl hexapeptide-49 was freeze-dried with liquid nitrogen for 40 minutes, and then acetyl hexapeptide-49 was added to an ethanol solution containing guaiac extract and cinting G57 at a mass ratio of 1:1, stirred at 5°C for 60 seconds, and then vacuum-dried to remove ethanol and water under a vacuum degree of 0.2 MPa and a temperature of 40°C to obtain modified acetyl hexapeptide-49;

[0085] Among them, in the ethanol solution containing guaiac extract and Cinnamomum camphora G57, the ratio of water:ethanol:guaiac extract:Cinnamomum camphora G57 is 60:30:20:15.

[0086] Step 3: First, according to the mass ratio, the purified water, thickener, emulsifier, penetrant and moisturizer were mixed uniformly at 80 ° C, and then cooled to 55 ° C, and the guaiac extract, isatis leaf extract and chamomile extract were added and mixed uniformly, and then cooled to 38 ° C, and the antimicrobial peptide LL-37 and acetyl tetrapeptide-40 were added and mixed uniformly, and finally, modified palmitoyl tripeptide-8 and modified acetyl hexapeptide-49 were added and stirred at a low speed of 14 rpm for 2 min to obtain a composition.

[0087] Example 6

[0088] A guaiac extract-containing acne-sensitive skin repair composition comprises, by weight, 3 parts of guaiac extract, 0.5 parts of isatis leaf extract, 2 parts of chamomile extract, 0.5 parts of antimicrobial peptide LL-37, 1 part of acetyl tetrapeptide-40, 1 part of modified palmitoyl tripeptide-8, and 1 part of modified acetyl hexapeptide-49; the surfaces of the modified palmitoyl tripeptide-8 and the modified acetyl hexapeptide-49 are coated with guaiac extract and Senting G57; the composition also comprises 0.5 parts of a thickener, 0.5 parts of an emulsifier, 1 part of a penetrant, 2 parts of a moisturizer, and 4 parts of purified water.

[0089] Among them, the guaiac extract, the isatis leaf extract and the chamomile extract are ethanol extracts.

[0090] In the composition of this embodiment, the thickener is a combination of xanthan gum, carbomer, and acrylic acid copolymer, with a mass ratio of xanthan gum:carbomer:acrylic acid copolymer = 1:2:1. The emulsifier is poloxamer. The penetrant is an alkyl glycoside. The humectant is a combination of glycerin, propylene glycol, butylene glycol, and ceramide, with a mass ratio of glycerin:propylene glycol:butylene glycol:ceramide = 2:1:1:2.

[0091] The preparation method of the acne-sensitive skin repairing composition containing guaiac extract comprises the following steps:

[0092] Step 1: Palmitoyl tripeptide-8 was freeze-dried with liquid nitrogen for 20 minutes, and then palmitoyl tripeptide-8 was added to an ethanol solution containing guaiac extract and cinting G57 at a mass ratio of 1:1. After stirring at 5°C for 30 seconds, the ethanol and water were removed by vacuum drying at a vacuum degree of 0.2 MPa and a temperature of 38°C to obtain modified palmitoyl tripeptide-8;

[0093] Among them, in the ethanol solution containing guaiac extract and Cinnamomum camphora G57, the ratio of water:ethanol:guaiac extract:Cinnamomum camphora G57 is 60:20:20:10.

[0094] Step 2: Acetyl hexapeptide-49 was freeze-dried with liquid nitrogen for 20 minutes, and then acetyl hexapeptide-49 was added to an ethanol solution containing guaiac extract and cinting G57 at a mass ratio of 1:1, stirred at 5°C for 30 seconds, and then vacuum-dried to remove ethanol and water under a vacuum degree of 0.2 MPa and a temperature of 38°C to obtain modified acetyl hexapeptide-49;

[0095] Among them, in the ethanol solution containing guaiac extract and Cinnamomum camphora G57, the ratio of water:ethanol:guaiac extract:Cinnamomum camphora G57 is 60:20:20:10.

[0096] Step 3: First, according to the mass ratio, the purified water, thickener, emulsifier, penetrant and moisturizer were mixed uniformly at 80 ° C, and then cooled to 50 ° C, and the guaiac extract, isatis leaf extract and chamomile extract were added and mixed uniformly, and then cooled to 38 ° C, and the antimicrobial peptide LL-37 and acetyl tetrapeptide-40 were added and mixed uniformly, and finally, modified palmitoyl tripeptide-8 and modified acetyl hexapeptide-49 were added and stirred at a low speed of 12 rpm for 2 min to obtain a composition.

[0097] Example 7

[0098] A acne-sensitive skin repairing composition containing guaiac extract, comprising the following components by weight: 6 parts of guaiac extract, 1 part of isatis indigo leaf extract, 4 parts of chamomile extract, 2 parts of antimicrobial peptide LL-37, 3 parts of acetyl tetrapeptide-40, 3 parts of modified palmitoyl tripeptide-8, and 3 parts of modified acetyl hexapeptide-49; the surfaces of the modified palmitoyl tripeptide-8 and the modified acetyl hexapeptide-49 are coated with guaiac extract and Senting G57; the composition also comprises 1 part of a thickener, 1 part of an emulsifier, 1.5 parts of a penetrant, 5 parts of a moisturizer, and 10 parts of purified water.

[0099] Among them, the guaiac extract, the isatis leaf extract and the chamomile extract are ethanol extracts.

[0100] In the composition of this embodiment, the thickener is a combination of carbomer and acrylic acid copolymer, with a mass ratio of carbomer to acrylic acid copolymer of 1:1.2. The emulsifier is a combination of lecithin and polysorbate 80, with a mass ratio of lecithin to polysorbate 80 of 2:1. The penetrant is an alkyl glycoside. The humectant is a combination of glycerin, butylene glycol, and ceramide, with a mass ratio of glycerin to butylene glycol to ceramide of 2:2:1.

[0101] The preparation method of the acne-sensitive skin repairing composition containing guaiac extract comprises the following steps:

[0102] Step 1: Palmitoyl tripeptide-8 was freeze-dried with liquid nitrogen for 40 minutes, and then palmitoyl tripeptide-8 was added to an ethanol solution containing guaiac extract and cinting G57 at a mass ratio of 1:1. After stirring at 10°C for 60 seconds, the ethanol and water were removed by vacuum drying at a vacuum degree of 0.3 MPa and a temperature of 40°C to obtain modified palmitoyl tripeptide-8;

[0103] Among them, in the ethanol solution containing guaiac extract and Cinnamomum camphora G57, the ratio of water:ethanol:guaiac extract:Cinnamomum camphora G57 is 80:30:25:15.

[0104] Step 2: Acetyl hexapeptide-49 was freeze-dried with liquid nitrogen for 40 minutes, and then acetyl hexapeptide-49 was added to an ethanol solution containing guaiac extract and cinting G57 at a mass ratio of 1:1, stirred at 10°C for 60 seconds, and then vacuum-dried to remove ethanol and water under a vacuum degree of 0.3 MPa and a temperature of 40°C to obtain modified acetyl hexapeptide-49;

[0105] Among them, in the ethanol solution containing guaiac extract and Cinnamomum camphora G57, the ratio of water:ethanol:guaiac extract:Cinnamomum camphora G57 is 80:30:25:15.

[0106] Step 3: First, according to the mass ratio, the purified water, thickener, emulsifier, penetrant and moisturizer were mixed uniformly at 85 ° C, and then cooled to 55 ° C, and the guaiac extract, isatis leaf extract and chamomile extract were added and mixed uniformly, and then cooled to 41 ° C, and the antimicrobial peptide LL-37 and acetyl tetrapeptide-40 were added and mixed uniformly, and finally, modified palmitoyl tripeptide-8 and modified acetyl hexapeptide-49 were added and stirred at a low speed of 14 rpm for 3 minutes to obtain a composition.

[0107] Example 8

[0108] A guaiac extract-containing acne-sensitive skin repair composition comprises, by weight, 3.5 parts of guaiac extract, 0.8 parts of isatis indigotica extract, 2.5 parts of chamomile extract, 1.8 parts of antimicrobial peptide LL-37, 3 parts of acetyl tetrapeptide-40, 1.2 parts of modified palmitoyl tripeptide-8, and 2.5 parts of modified acetyl hexapeptide-49; the surfaces of the modified palmitoyl tripeptide-8 and the modified acetyl hexapeptide-49 are coated with guaiac extract and Senting G57; the composition also comprises 0.6 parts of a thickener, 0.8 parts of an emulsifier, 1.2 parts of a penetrant, 4 parts of a moisturizer, and 5.5 parts of purified water.

[0109] Among them, the guaiac extract, the isatis leaf extract and the chamomile extract are ethanol extracts.

[0110] In the composition of this embodiment, the thickener is carbomer. The emulsifier is poloxamer. The penetrant is an alkyl glycoside. The moisturizer is a combination of butylene glycol and ceramide, with a mass ratio of butylene glycol to ceramide of 2:1.

[0111] The preparation method of the acne-sensitive skin repairing composition containing guaiac extract comprises the following steps:

[0112] Step 1: Palmitoyl tripeptide-8 was freeze-dried with liquid nitrogen for 25 minutes, and then palmitoyl tripeptide-8 was added to an ethanol solution containing guaiac extract and cinting G57 at a mass ratio of 1:1. After stirring at 8°C for 40 seconds, the ethanol and water were removed by vacuum drying at a vacuum degree of 0.3 MPa and a temperature of 40°C to obtain modified palmitoyl tripeptide-8;

[0113] Among them, in the ethanol solution containing guaiac extract and Cinnamomum camphora G57, the ratio of water:ethanol:guaiac extract:Cinnamomum camphora G57 is 65:25:20:12.

[0114] Step 2: Acetyl hexapeptide-49 was freeze-dried with liquid nitrogen for 25 minutes, and then acetyl hexapeptide-49 was added to an ethanol solution containing guaiac extract and cinting G57 at a mass ratio of 1:1, stirred at 9°C for 40 seconds, and then vacuum-dried to remove ethanol and water under a vacuum degree of 0.3 MPa and a temperature of 40°C to obtain modified acetyl hexapeptide-49;

[0115] Among them, in the ethanol solution containing guaiac extract and Cinnamomum camphora G57, the ratio of water:ethanol:guaiac extract:Cinnamomum camphora G57 is 65:25:20:12.

[0116] Step 3: First, according to the mass ratio, the purified water, thickener, emulsifier, penetrant and moisturizer were mixed uniformly at 85 ° C, and then cooled to 54 ° C, and the guaiac extract, isatis leaf extract and chamomile extract were added and mixed uniformly, and then cooled to 40 ° C, and the antimicrobial peptide LL-37 and acetyl tetrapeptide-40 were added and mixed uniformly, and finally, modified palmitoyl tripeptide-8 and modified acetyl hexapeptide-49 were added and stirred at a low speed of 14 rpm for 2 min to obtain a composition.

[0117] The compositions of Examples 2 to 8 were tested.

[0118] 1. Safety tests were conducted on the compositions of Examples 2 to 8 respectively according to conventional testing methods. The raw materials of the compositions were all raw materials allowed to be added to cosmetics and were safe and non-toxic.

[0119] 2. Experiment on the repair effect of acne-sensitive skin:

[0120] 70 subjects with acne-sensitive skin who were positive for lactic acid stinging were randomly divided into 7 groups, with 10 subjects in each group. The compositions of Examples 2 to 8 were applied to the face once in the morning and once in the evening. The effects of acne-sensitive skin repair were observed and tested, as shown in the following table:

[0121] The experimental results show that the repairing effects of the compositions of Examples 2 to 8 on acne-sensitive skin are comparable to that of the composition of Example 1.

Claims

1. A acne-sensitive skin repairing composition containing guaiac extract, characterized in that: The composition comprises 3 to 6 parts by weight of guaiac extract, 0.5 to 1 part of isatis leaf extract, 2 to 4 parts of chamomile extract, 0.5 to 2 parts of antimicrobial peptide LL-37, 1 to 3 parts of acetyl tetrapeptide-40, 1 to 3 parts of modified palmitoyl tripeptide-8 and 1 to 3 parts of modified acetyl hexapeptide-49; the surfaces of the modified palmitoyl tripeptide-8 and the modified acetyl hexapeptide-49 are coated with guaiac extract and Senting G57; the composition further comprises 0.5 to 1 part of thickener, 0.5 to 1 part of emulsifier, 1 to 1.5 parts of penetrant, 2 to 5 parts of moisturizer and 4 to 10 parts of purified water; The guaiac extract, the isatis leaf extract and the chamomile extract are ethanol extracts; the thickener is one or more combinations of xanthan gum, carbomer and acrylic acid copolymer; the emulsifier is one or more combinations of poloxamer, lecithin and Tween 80; the penetrant is an alkyl glycoside; The preparation method of the composition comprises the following steps: Step 1: freeze-dry palmitoyl tripeptide-8 with liquid nitrogen, then add palmitoyl tripeptide-8 to an ethanol solution containing guaiac extract and Cinnamomum camphora G57 at a mass ratio of 1:1, stir evenly at a low temperature of 5°C to 10°C, and vacuum dry to remove ethanol and water to obtain modified palmitoyl tripeptide-8; In the ethanol solution containing the guaiac extract and the centenary G57, water:ethanol:guaiac extract:centenary G57=(60-80):(20-30):(20-25):(10-15); Step 2: freeze-dry acetyl hexapeptide-49 with liquid nitrogen, then add acetyl hexapeptide-49 to an ethanol solution containing guaiac extract and Cinnamyl G57 at a mass ratio of 1:1, stir evenly at a low temperature of 5°C to 10°C, and vacuum dry to remove ethanol and water to obtain modified acetyl hexapeptide-49; In the ethanol solution containing the guaiac extract and the centenary G57, water:ethanol:guaiac extract:centenary G57=(60-80):(20-30):(20-25):(10-15); Step 3: First, according to the mass ratio, the purified water, thickener, emulsifier, penetrant and moisturizer are mixed uniformly at 80°C to 85°C, then cooled to 50°C to 55°C, and then the guaiac extract, the isatis leaf extract and the chamomile extract are added and mixed uniformly, and then the antimicrobial peptide LL-37 and acetyl tetrapeptide-40 are added and mixed uniformly after cooling to 38°C to 41°C, and finally the modified palmitoyl tripeptide-8 and the modified acetyl hexapeptide-49 are added and stirred at a low speed to obtain a composition.

2. The acne-sensitive skin repairing composition containing guaiac extract according to claim 1, characterized in that: The moisturizing agent is one or more combinations of glycerin, propylene glycol, butylene glycol and ceramide.

3. The acne-sensitive skin repairing composition containing Guaiac extract according to claim 1, characterized in that: In step 1, the liquid nitrogen freeze-drying time is 20 min to 40 min; the low-temperature stirring time is 30 s to 60 s.

4. The acne-sensitive skin repairing composition containing Guaiac extract according to claim 1, characterized in that: In step 2, the liquid nitrogen freeze-drying time is 20 min to 40 min; the low-temperature stirring time is 30 s to 60 s.

5. The acne-sensitive skin repairing composition containing Guaiac extract according to claim 1, characterized in that: In step 3, the low-speed mixing speed is 12 rpm to 14 rpm, and the time is 2 min to 3 min.

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