Nicotine liquid preparation, and preparation method therefor and use thereof

Abstract

A nicotine liquid preparation, and a preparation method therefor and the use thereof. The raw material components of the nicotine liquid preparation comprise nicotine, an additive capable of simulating the head-rush feeling of nicotine, an atomization solvent and an organic acid. The additive capable of simulating the head-rush feeling of nicotine is selected from at least one of cytisine, magnolol and 6-methylnicotine. The nicotine liquid preparation has a nicotine content of 10-20 mg / g.

Description

Nicotine liquid preparation, preparation method and application thereof

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS

[0002] This application claims priority to the Chinese patent application filed with the China Patent Office on December 8, 2023, with application number 202311690126.1 and invention name “A nicotine liquid preparation, its preparation method and application”, the entire contents of which are incorporated by reference into this application. Technical Field

[0003] The present application relates to the field of electronic atomization technology, and specifically to a nicotine liquid preparation, a preparation method, and an application thereof. Background Art

[0004] An electronic atomization system is a smoking alternative that delivers nicotine without tobacco smoke. This system delivers nicotine into the bloodstream, effectively reducing tobacco intake and helping smokers quit, similar to nicotine replacement therapy. An electronic atomization system primarily consists of a cartridge, an atomizer, and a power supply. The cartridge is a container for liquid nicotine preparations, which primarily contain nicotine, propylene glycol, glycerin, and flavors. The atomizer, powered by a battery, atomizes the liquid nicotine in the cartridge into a scented aerosol for the user.

[0005] The core ingredient in nicotine liquid preparations is nicotine. When the power supply heats the atomizer, the nicotine in the nicotine liquid preparation is atomized into an aerosol and then inhaled by the human body, thereby bringing a sense of satisfaction. However, nicotine is highly toxic and addictive, and long-term inhalation can affect human health. To prevent nicotine abuse and protect public health and safety, countries currently strictly regulate nicotine, basically limiting nicotine content to 20mg / g or less. However, a decrease in nicotine content will lead to a decrease in satisfaction. To improve consumer satisfaction, existing technologies generally use low-content nicotine in the form of nicotine salts. The organic acid commonly used to form nicotine salts is benzoic acid. By compounding benzoic acid with low-content nicotine, satisfaction is improved, but the improvement effect is still limited.

[0006] Summary of the Invention

[0007] The purpose of this application is to overcome the defects in the prior art that nicotine has high toxicity and addictiveness, and long-term inhalation can affect human health, while the combination of low-content nicotine and benzoic acid has limited effect on improving user satisfaction, and thus provide a nicotine liquid preparation and its preparation method and application.

[0008] To achieve the above objectives, this application adopts the following technical solutions:

[0009] The present application provides a nicotine liquid preparation, wherein the raw material components of the nicotine liquid preparation include nicotine, a nicotine head-feeling simulating additive, an atomizing solvent, and an organic acid;

[0010] The nicotine high-sensation simulating additive is selected from at least one of cytisine, magnolol, and 6-methylnicotine;

[0011] The nicotine content in the nicotine liquid preparation is 10-20 mg / g.

[0012] Optionally, the mass ratio of the nicotine-high-feeling simulating additive to nicotine is (0.1-3.7):(1-2);

[0013] Optionally, the mass ratio of the nicotine-high-feeling simulating additive to nicotine is (1-3.7):(1-2).

[0014] Optionally, the nicotine head feeling simulating additive is selected from at least two of cytisine, magnolol, and 6-methylnicotine.

[0015] Optionally, the nicotine high-sensation simulating additives are cytisine and magnolol;

[0016] The mass ratio of cytisine to magnolol is (1-20): (1-10);

[0017] Optionally, the mass of the cytisine accounts for 0.1-2% of the mass of the nicotine liquid preparation;

[0018] The mass of the magnolol accounts for 0.1-1% of the mass of the nicotine liquid preparation.

[0019] Optionally, the nicotine high-sensation simulating additives are cytisine, magnolol and 6-methylnicotine;

[0020] The mass ratio of cytisine, magnolol and 6-methylnicotine is (1-20): (1-10): (1-10);

[0021] Optionally, the mass of the cytisine accounts for 0.1-2% of the mass of the nicotine liquid preparation;

[0022] The mass of the magnolol accounts for 0.1-1% of the mass of the nicotine liquid preparation;

[0023] The mass of the 6-methylnicotine accounts for 0.1-1% of the mass of the nicotine liquid preparation.

[0024] Optionally, the mass ratio of the atomizing solvent to nicotine is (40-97.8): (1-2).

[0025] Optionally, the atomizing solvent includes at least one of propylene glycol, glycerol, water, ethanol, triacetin, and sorbitol.

[0026] Optionally, the atomizing solvent is propylene glycol and glycerol;

[0027] The mass ratio of the propylene glycol to the glycerol is (1-50): (1-50).

[0028] Optionally, the organic acid comprises at least one of C3-C8 organic carboxylic acids;

[0029] Optionally, the organic acid includes at least one of C3-C8 monobasic organic carboxylic acid, C3-C8 dibasic organic carboxylic acid, and C3-C8 tribasic organic carboxylic acid.

[0030] Optionally, the organic acid includes at least one of salicylic acid, citric acid, malic acid, benzoic acid, levulinic acid, tartaric acid, and succinic acid;

[0031] Optionally, the organic acid is benzoic acid.

[0032] Optionally, the organic acid is calculated based on the carboxyl group, and the molar ratio of the organic acid to the nicotine is (1-2): (1-2);

[0033] Optionally, the organic acid is calculated based on the carboxyl group, and the molar ratio of the organic acid to the nicotine is 1:1.

[0034] Optionally, the organic acid is calculated based on carboxyl groups, and the molar ratio of the total molar amount of nicotine and 6-methylnicotine to the organic acid is (0.98-2):(0.98-2);

[0035] Optionally, the organic acid is calculated based on carboxyl groups, and the molar ratio of the total molar amount of nicotine and 6-methylnicotine to the molar amount of the organic acid is 1:1.

[0036] Optionally, the molar amount of the organic acid is calculated based on the carboxyl group, and the molar amount ratio of the organic acid to 6-methylnicotine is (1-2):(1-2).

[0037] Optionally, in the nicotine liquid preparation, the nicotine and the organic acid may exist in the form of nicotine organic acid salt, and the 6-methylnicotine and the organic acid may exist in the form of 6-methylnicotine organic acid salt.

[0038] Optionally, the raw material components of the nicotine liquid preparation further include flavors.

[0039] Optionally, the flavor includes at least one of tobacco flavor, fruit flavor, and mint flavor;

[0040] Optionally, the fruit flavor includes at least one of blueberry flavor, strawberry flavor, and watermelon flavor.

[0041] Optionally, the mass ratio of the flavor to nicotine is (20-50):(1-2).

[0042] The nicotine liquid preparation described in this application is used to enhance satisfaction and, further, to improve the consumer's smoking experience.

[0043] The present application provides a method for preparing the above-mentioned nicotine liquid preparation, comprising the following steps:

[0044] The nicotine, the nicotine high-feeling simulating additive, the atomizing solvent and the organic acid are mixed, and then heated and stirred to obtain the product.

[0045] Optionally, the method for preparing the nicotine liquid preparation further comprises the step of adding flavoring.

[0046] The present application does not specifically limit the stirring method. Optionally, the stirring method is selected from mechanical stirring, mechanical oscillation or ultrasonic oscillation.

[0047] The present application provides a use of the above-mentioned nicotine liquid preparation or the nicotine liquid preparation prepared by the above-mentioned preparation method in an atomization device.

[0048] Optionally, the atomization device is an electronic atomization device.

[0049] Beneficial effects of this application:

[0050] The nicotine liquid preparation provided by the present application comprises raw material components including nicotine, a nicotine head-feeling simulating additive, an atomizing solvent, and an organic acid; the nicotine head-feeling simulating additive is selected from at least one of cytisine, magnolol, and 6-methylnicotine; and the nicotine content in the nicotine liquid preparation is 10-20 mg / g. The present application uses a nicotine head-feeling simulating additive (at least one of cytisine, magnolol, and 6-methylnicotine) to induce a head-feeling effect similar to that of nicotine in the brain, partially replacing the activating effect of nicotine, and using a low content (10-20 mg / g) of nicotine to provide a throat hit; the nicotine liquid preparation formed by compounding a specific nicotine head-feeling simulating additive and nicotine, under the synergistic effect of each component, is conducive to enhancing the user's satisfaction with the low-nicotine content liquid preparation, and reducing toxicity and addictiveness and health damage under the same puffing experience. BRIEF DESCRIPTION OF THE DRAWINGS

[0051] In order to more clearly illustrate the specific implementation methods of the present application or the technical solutions in the prior art, the following is a brief introduction to the drawings required for use in the specific implementation methods or the description of the prior art. Obviously, the drawings described below are some implementation methods of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without any creative work.

[0052] Figure 1 is a normalized heart rate diagram of Example 2, Example 6, Example 12, Example 13 and Comparative Example 1 of the present application;

[0053] Figure 2 is a graph of the average normalized heart rates of Examples 2, 6, 12, 13 and Comparative Example 1 of the present application. DETAILED DESCRIPTION

[0054] The following examples are provided to further better understand the present application, but are not limited to the best implementation mode described herein, and do not limit the content and protection scope of the present application. Any product identical or similar to the present application obtained by anyone under the inspiration of the present application or by combining the features of the present application with other prior arts shall fall within the scope of protection of the present application.

[0055] If no specific experimental steps or conditions are specified in the examples, the conventional experimental steps or conditions described in the literature in this field can be used. If the manufacturer of the reagents or instruments is not specified, they are all commercially available conventional reagents.

[0056] The core ingredient in nicotine liquid preparations is nicotine. When the power source heats the atomizer, the nicotine in the nicotine liquid preparation is atomized into an aerosol and then inhaled by the human body. Part of the aerosol is transmitted to the throat, which is also distributed with acetylcholine receptors. The nicotine deposited in the throat can bind to the acetylcholine receptors, causing a throat hit. Another part of the aerosol enters the lungs and participates in the pulmonary venous circulation. Then it enters the arterial circulation, rapidly transmitting nicotine to the brain, where it binds to the acetylcholine receptors in the brain and promotes the release of neurotransmitters (dopamine). Dopamine release is a pleasurable experience that will enhance the brain's reward function, produce a feeling of being high, and give the smoker a sense of satisfaction. Satisfaction is a comprehensive evaluation of the feeling of being high and the throat hit. The appropriate throat hit can help improve the overall sense of satisfaction. However, if the throat hit is too strong, it will cause excessive inhalation irritation and physical discomfort, reducing satisfaction. Nicotine is highly toxic and addictive, and long-term inhalation can affect human health. To prevent nicotine abuse and protect public health and safety, countries currently strictly regulate nicotine in e-cigarette products, limiting nicotine content to 20mg / g or less. However, a decrease in nicotine content can lead to a decrease in consumer satisfaction. To enhance consumer satisfaction, existing technologies generally use nicotine in the form of nicotine salts. Benzoic acid is a common organic acid used to form nicotine salts. Combining nicotine with benzoic acid to achieve increased satisfaction, but the effect remains limited.

[0057] Cytisine, a leguminous plant extract, has been shown to have a high affinity for the α4β2 subtype of nicotinic acetylcholine receptors, acting as a low-nonspecific partial agonist. The inventors discovered that cytisine can interact with acetylcholine receptors in the brain, producing a nicotine-like activation effect, synergizing with nicotine to enhance satisfaction.

[0058] Magnolia officinalis is an active ingredient in Magnolia officinalis plant extracts, exhibiting sedative, hypnotic, anxiolytic, and antiepileptic properties. Magnolia officinalis can increase the 5-hydroxyindoleacetic acid / 5-hydroxytryptamine (5-HIAA / 5-HT) ratio in the frontal cortex, striatum, and nucleus accumbens, inhibit increases in serum corticosterone levels, and reverse the decrease in platelet adenylate cyclase activity induced by chronic mild stress (CMS), exerting an antidepressant effect. Magnolia officinalis can counteract the inhibitory effect of exogenous morphine on endogenous enkephalin release, alleviating withdrawal symptoms. Magnolia officinalis can also counteract the excitatory effects of the central nervous system excitatory neurotransmitters glutamate and N-methyl-D-aspartate (NMDA) by promoting β-endorphin release and stimulating cannabinoid receptors. Magnolia officinalis primarily counteracts the damage caused by excitatory neurotransmitters to nerve cells by promoting the biosynthesis of γ-aminobutyric acid (GABA), increasing GABA levels, and enhancing GABA binding to receptors.

[0059] 6-Methylnicotine (CAS: 13270-56-9) is an organic intermediate and a nicotine analog. The affinity of nicotine analogs for nicotinic acetylcholine receptors (nAChRs) is reportedly related to the lipophilicity of the 6-substituent. Related research further demonstrates that affinity decreases with increasing substituent size. The affinity of nicotine analogs is determined by the lipophilicity of the 6-substituent, which is also related to the size of the substituent. Among them, 6-methylnicotine has the smallest 6-substituent and is highly lipophilic, exhibiting strong affinity for nAChR receptors and promising pharmaceutical prospects.

[0060] The inventors unexpectedly discovered that compounding nicotine with a nicotine-high-mimicking additive (at least one of cytisine, magnolol, and 6-methylnicotine) results in a synergistic effect between nicotine and the nicotine-high-mimicking additive, which helps enhance user satisfaction while maintaining a nicotine content of no more than 20 mg / g.

[0061] The present application provides a nicotine liquid preparation, the raw material components of which include nicotine, a nicotine head-feeling simulating additive, an atomizing solvent, and an organic acid; the nicotine head-feeling simulating additive is selected from at least one of cytisine, magnolol, and 6-methylnicotine; and the nicotine content in the nicotine liquid preparation is 10-20 mg / g. The present application uses a nicotine head-feeling simulating additive (at least one of cytisine, magnolol, and 6-methylnicotine) to make the brain produce a head-feeling effect similar to that of nicotine, which can partially replace the activating effect of nicotine and use a low content (10-20 mg / g) of nicotine to provide a throat hit; the nicotine liquid preparation formed by the compounding of a specific nicotine head-feeling simulating additive and nicotine, under the synergistic effect of each component, is conducive to enhancing the user's satisfaction with the low-nicotine content liquid preparation, while reducing toxicity and addictiveness and reducing health damage under the same experience. Alternatively, in some optional embodiments, the nicotine content in the nicotine liquid preparation is 10 mg / g, 11 mg / g, 12 mg / g, 13 mg / g, 14 mg / g, 15 mg / g, 16 mg / g, 17 mg / g, 18 mg / g, 19 mg / g, or 20 mg / g.

[0062] In some optional embodiments, the mass ratio of the nicotine head feeling simulation additive to nicotine is (0.1-3.7): (1-2); for example, the mass ratio of the nicotine head feeling simulation additive to nicotine can be selected as 0.1:1, 0.2:1, 0.3:1, 0.5:1, 0.7:1, 0.9:1, 1:1, 1.3:1, 1.4:1, 1.5:1, 1.7:1, 1.8:1, 1.9:1, 2:1, 2.1:1, 2.3:1, 2.5:1, 2.8:1, 3:1, 3.1:1, 3.3:1, 3.4:1, 3.5:1, 3.7:1, 0.1:1.25, 0.2:1.25, 0.3:1 0.25, 0.5:1.25, 0.7:1.25, 0.9:1.25, 1:1.25, 1.3:1.25, 1.4:1.25, 1.5:1.25, 1.7:1.25, 1.8:1.25, 1.9:1.25, 2:1.25, 2.1:1.25, 2.3:1.25, 2.5:1.25, 2.8:1.25, 3:1.25, 3.1:1.25, 3.3:1.25, 3.4:1.25, 3.5:1.25, 3.7:1.25, 0.1:1.5, 0.2:1.5, 0.3:1.5, 0.5:1.5, 0.7:1.5, 0.9:1.5, 1:1.5 , 1.3:1.5, 1.4:1.5, 1.5:1.5, 1.7:1.5, 1.8:1.5, 1.9:1.5, 2:1.5, 2.1:1.5, 2.3:1.5, 2.5:1.5, 2.8:1.5, 3:1.5, 3.1:1.5, 3.3:1.5, 3.4:1.5, 3.5:1.5, 3.7:1.5, 0.1:1.75, 0.2:1.75, 0.3:1.75, 0.5:1.75, 0.7:1.75, 0.9:1.75, 1:1.75, 1.3:1.75, 1.4:1.75, 1.5:1.75, 1.7:1.75, 1.8:1.75, 1 .9:1.75, 2:1.75, 2.1:1.75, 2.3:1.75, 2.5:1.75, 2.8:1.75, 3:1.75, 3.1:1.75, 3.3:1.75, 3.4:1.75, 3.5:1.75, 3.7:1.75, 0.1:2, 0.2:2, 0.3:2, 0.5:2, 0.7:2, 0.9:2, 1:2, 1.3:2, 1.4:2, 1.5:2, 1.7:2, 1.8:2, 1.9:2, 2:2, 2.1:2, 2.3:2, 2.5:2, 2.8:2, 3:2, 3.1:2, 3.3:2, 3.4:2, 3.5:2, 3.7:2.Optionally, the mass ratio of the nicotine high-feeling simulating additive to nicotine is (1-3.7): (1-2). The inventors found that by controlling the mass ratio of the nicotine high-feeling simulating additive to nicotine within the range of (1-3.7): (1-2), the user's satisfaction is further improved under their synergistic effect.

[0063] In some optional embodiments, the nicotine high-stimulating additive is selected from at least two of cytisine, magnolol, and 6-methylnicotine. The inventors have discovered that when at least two of these additives are selected, user satisfaction is significantly improved compared to using only one of these additives alone, and can even achieve a satisfaction level comparable to or better than that of a commercially available nicotine liquid formulation containing benzoic acid as the organic acid and containing 30 mg / g of nicotine.

[0064] In some optional embodiments, the nicotine head feeling simulating additive is cytisine and magnolol; the mass ratio of cytisine and magnolol is (1-20): (1-10); for example, the mass ratio of cytisine and magnolol can be selected as 1:1, 3:1, 4:1, 5:1, 7:1, 8:1, 9:1, 10:1, 11:1, 13:1, 15:1, 17:1, 19:1, 20:1, 1:3, 3:3, 4:3, 5:3, 7:3, 8:3, 9:3, 10:3, 11:3, 13:3, 15:3, 17:3, 19:3, : 7, 3: 7, 4: 7, 5: 7, 7: 7, 8: 7, 9: 7, 10: 7, 11: 7, 13: 7, 15: 7, 17: 7, 19: 7, 20: 7, 1: 10, 3: 10, 4: 10, 5: 10, 7: 10, 8: 10, 9: 10, 10: 10, 11: 10, 13: 10, 15: 10, 17: 10, 19: 7, 20: 7, 1: 10, 3: 10, 4: 10, 5: 10, 7: 10, 8: 10, 9: 10, 10: 10, 11: 10, 13: 10, 15: 10, 17: 10, 19: 10, 20: 10. Optionally, the mass of cytisine accounts for 0.1-2% of the mass of the nicotine liquid preparation; the mass of magnolol accounts for 0.1-1% of the mass of the nicotine liquid preparation. For example, the mass of cytisine can be selected to account for 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, or 2% of the mass of the nicotine liquid preparation; the mass of magnolol accounts for 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1% of the mass of the nicotine liquid preparation.

[0065] In some optional embodiments, the nicotine high-sensation simulating additive is cytisine, magnolol, and 6-methylnicotine. The inventors have found that when the nicotine high-sensation simulating additive is selected from cytisine, magnolol, and 6-methylnicotine and used synergistically, the user's satisfaction is most significantly improved, and the satisfaction can even reach the satisfaction of a nicotine liquid preparation on the market with benzoic acid as the organic acid and a nicotine content of 50 mg / g. Under the condition of the same experience, the toxicity and addictiveness can be effectively reduced, and the health damage can be reduced. The mass ratio of cytisine, magnolol and 6-methylnicotine is (1-20): (1-10): (1-10); for example, the mass ratio of cytisine and magnolol can be selected as 1:1:1, 3:1:2, 4:1:1, 5:1:5, 7:1:9, 8:1:10, 9:1:1, 10:1:9, 11:1:1, 13:1:6, 15:1:6, 17:1:2, 19:1:1, 20:1:9, 1:3, 3:3:1, 4:3:1, 5:3:4, 7:3:6, 8:3:1, 9:3:8, 10:3:10, 11:3:10, 13:3:3, 15:3:1, 17:3:9, 19:3:2, 20:3:10, 1:5:1, 3:5:10, 4:5:2, 5:5:5 , 7:5:6, 8:5:9, 9:5:10, 10:5:1, 11:5:6, 13:5:9, 15:5:10, 17:5:8, 19:5:8, 20:5:9, 1:7:8, 3:7:9, 4:7:10, 5:7:10, 7:7:1, 8:7:1, 9:7:2, 10:7:10, 11:7:9, 13:7:10, 15:7:1, 17:7:1, 19:7:10, 20:7:5, 1:10:1, 3:10:2, 4:10:10, 5:10:10, 7:10:1, 8:10:5, 9:10:9, 10:10:5, 11:10:4, 13:10:3, 15:10:7, 17:10:10, 19:10:8, 20:10:8. Optionally, the mass of the cytisine accounts for 0.1-2% of the mass of the nicotine liquid preparation; the mass of the magnolol accounts for 0.1-1% of the mass of the nicotine liquid preparation; and the mass of the 6-methylnicotine accounts for 0.1-1% of the mass of the nicotine liquid preparation.For example, it can be selected that the mass of the cytisine accounts for 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.1%, 1.2%, 1.3%, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9%, or 2% of the mass of the nicotine liquid preparation; the mass of the magnolol accounts for 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1% of the mass of the nicotine liquid preparation; and the mass of the 6-methylnicotine accounts for 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, or 1% of the mass of the nicotine liquid preparation.

[0066] In some optional embodiments, the atomizing solvent may be a conventional atomizing solvent in the art, including but not limited to at least one of propylene glycol, glycerol, water, ethanol, triacetin, and sorbitol; optionally, the mass ratio of the atomizing solvent to nicotine is (40-97.8): (1-2), for example, the mass ratio of the atomizing solvent to nicotine that can be selected is 40:1, 45:1, 47:1, 50:1, 60:1, 70:1, 80:1, 90:1, 97.8:1, 40:1.5, 45:1.5, 47:1.5, 50:1.5, 60:1.5, 70:1.5, 80:1.5, 90:1.5, 97.8:1.5, 40:2, 45:2, 47:2, 50:2, 60:2, 70:2, 80:2, 90:2, 97.8:2. Optionally, the atomizing solvent is propylene glycol and glycerol. The mass ratio of propylene glycol to glycerol is (1-50): (1-50). For example, the mass ratio of propylene glycol to glycerol can be selected from 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7, 1:8, 1:9, 1:10, 1:13, 1:15, 1:20, 1:25, 1:30, 1:35, 1:40, 1:45, 1:50, 2:1, 2:3, 2:5, 2:7, 2:9, 2:1 0, 2:13, 2:15, 2:20, 2:25, 2:30, 2:35, 2:40, 2:45, 2:50, 3:1, 4:1, 5:1, 6:1, 7:1, 8:1, 9:1, 10:1, 12:1, 13:1, 15:1, 18:1, 20:1, 22:1, 25:1, 29:1, 30:1, 32:1, 35:1, 40:1, 43:1, 45:1, 47:1, 50:1. The addition of the atomizing solvent in this application can better dissolve the raw material components, effectively improve the atomization efficiency of nicotine, and increase the sense of satisfaction.

[0067] In some optional embodiments, the atomizing solvent is propylene glycol, glycerol and ethanol. For example, the mass ratio of propylene glycol, glycerol and ethanol can be selected to be (1-50): (1-50): (1-2).

[0068] In some optional embodiments, the organic acid comprises at least one of a C3-C8 organic carboxylic acid; further optionally, the organic acid comprises at least one of a C3-C8 monocarboxylic acid, a C3-C8 dicarboxylic acid, or a C3-C8 tricarboxylic acid. Further optionally, the organic acid comprises at least one of salicylic acid, citric acid, malic acid, benzoic acid, levulinic acid, tartaric acid, and succinic acid; and further optionally, the organic acid is benzoic acid. By further adding a specific organic acid to the raw material components to form the nicotine salt, the present application can further ensure user satisfaction.

[0069] In some optional embodiments, the molar amount of the organic acid is calculated based on the carboxyl group, and the molar amount ratio of the organic acid to nicotine is (1-2): (1-2); for example, the molar amount of the organic acid is calculated based on the carboxyl group, and the molar amount ratio of the organic acid to nicotine is 1:1, 1.1:1, 1.2:1, 1.3:1, 1.4:1, 1.5:1, 1.6:1, 1.7:1, 1.8:1, 1.9:1, 2:1, 1:1.2, 1.1:1.2, 1.2:1.2, 1.3:1.2, 1.4:1.2, 1.5:1.2, 1.6:1.2, 1.7:1.2, 1.8:1.2, 1.9:1.2, 2:1.2, 1:1.5, 1.1:1.5, 1.2:1.5, 1.3:1.5, 1.4:1.5, 1.5:1.5, 1.6:1.5, 1.7:1.5, 1.8 The following are the ratios of organic acid to nicotine: 1.5, 1.9:1.5, 2:1.5, 1:1.7, 1.1:1.7, 1.2:1.7, 1.3:1.7, 1.4:1.7, 1.5:1.7, 1.6:1.7, 1.7:1.7, 1.8:1.7, 1.9:1.7, 2:1.7, 1:2, 1.1:2, 1.2:2, 1.3:2, 1.4:2, 1.5:2, 1.6:2, 1.7:2, 1.8:2, 1.9:2, and 2:2. After adding a synergistic substance, a nicotine high-dose simulating additive, the inventors further discovered that the amount of organic acid added affects satisfaction. Benzoic acid and nicotine combine to form a salt state. Changing the molar ratio of organic acid to nicotine can change the acid-base environment in the throat, affecting the intensity of the throat hit during the aerosol's entry into the lungs. The inventors discovered that when the molar ratio of the organic acid, calculated as the carboxyl group, to the molar ratio of nicotine is (1-2):(1-2), both the heady feeling and the throat hit during inhalation change, resulting in a high overall sense of satisfaction.

[0070] In some optional embodiments, the organic acid is calculated based on the carboxyl group, and the molar ratio of the organic acid to the 6-methylnicotine is (1-2): (1-2); for example, the organic acid can be selected based on the carboxyl group, and the molar ratio of the organic acid to the 6-methylnicotine is 1:1, 1.1:1, 1.2:1, 1.3:1, 1.4:1, 1.5:1, 1.6:1, 1.7:1, 1.8:1, 1.9:1, 2:1, 1:1.2, 1.1:1.2, 1.2:1.2, 1.3:1.2, 1.4:1.2, 1.5:1.2, 1.6:1.2, 1.7:1.2, 1.8:1.2, 1.9:1.2, : 1.7, 1.4: 1.7, 1.5: 1.7, 1.6: 1.7, 1.8: 1.7, 1.9: 1.7, 2: 1.7, 1: 2, 1.1: 2, 1.2: 2, 1.3: 2, 1.4: 2, 1.5: 2, 1.6: 2, 1.7: 2, 1.8: 2, 1.9: 2, 2: 2.

[0071] In some optional embodiments, the molar ratio of the total molar amount of nicotine and 6-methylnicotine to the organic acid is (0.98-2): (0.98-2) based on the carboxyl group of the organic acid. For example, the molar ratio of the total molar amount of nicotine and 6-methylnicotine to the organic acid is 0.98:0.99, 0.99:0.98, 0.98:1, 0.99:1, 1:1, 1.1:1, 1.2:1, 1.3:1, 1.4:1, 1.5:1, 1.6:1, 1.7:1, 1.8:1, 1.9:1, 1.9:1, 1.9:1, 1.9:1, 1.9:1, 1.9:1, 1.9:1, 1.9:1, 1.9:1, 1.9:1, 1.9:1, 1.9:1, 1.9:1 :1, 2:1, 0.98:1.2, 0.99:1.2, 1:1.2, 1.1:1.2, 1.2:1.2, 1.3:1.2, 1.4:1.2, 1.5:1.2, 1.6:1.2, 1.7:1.2, 1.8:1.2, 1.9:1.2, 2:1.2, 0.98:1.5, 0.99:1.5, 1:1.5, 1. 1:1.5, 1.2:1.5, 1.3:1.5, 1.4:1.5, 1.5:1.5, 1.6:1.5, 1.7:1.5, 1.8:1.5, 1.9:1.5, 2:1.5, 0.98:1.7, 0.99:1.7, 1:1.7, 1.1:1.7, 1.2:1.7, 1.3:1.7, 1.4:1.7, 1.5 The ratios of organic acids were 1:1.7, 1.6:1.7, 1.7:1.7, 0.98:1.8, 0.99:1.8, 1.8:1.7, 1.9:1.7, 2:1.7, 0.98:2, 0.99:2, 1:2, 1.1:2, 1.2:2, 1.3:2, 1.4:2, 1.5:2, 1.6:2, 1.7:2, 1.8:2, 1.9:2, and 2:2. After adding a synergistic nicotine high-mimicking additive, the inventors further discovered that the amount of organic acid added affects satisfaction. Nicotine and 6-methylnicotine both combine with benzoic acid to form salts. Changing the molar ratio of the total molar amount of nicotine and 6-methylnicotine to the molar amount of the organic acid can alter the acid-base environment in the throat, affecting the intensity of the throat hit during aerosol entry into the lungs. The inventors discovered that when the molar ratio of the total molar amount of nicotine and 6-methylnicotine to the molar amount of the organic acid, calculated as the carboxyl group, is (0.98-2):(0.98-2), both the heady feeling and the throat hit during inhalation are changed, resulting in a higher overall sense of satisfaction.

[0072] In some optional embodiments, the raw material components of the nicotine liquid preparation also include flavors. The flavors can be conventional existing flavor materials in the field, which can be obtained commercially or prepared by conventional preparation methods. For example, they can be selected from monomeric flavor raw materials or a variety of extracts. Including but not limited to tobacco flavors, fruit flavors, mint flavors. Furthermore, the fruit flavors include at least one of blueberry flavors, strawberry flavors, and watermelon flavors; optionally, the mass ratio of the flavor to nicotine is (20-50): (1-2), for example, the mass ratio of flavor to nicotine can be selected to be 20:1, 22:1, 25:1, 27:1, 30:1, 32:1, 35:1, 37:1, 39:1, 40:1, 42:1. :1, 45:1, 47:1, 49:1, 50:1, 20:1.2, 22:1.2, 25:1.2, 27:1.2, 30:1.2, 32:1.2, 35:1.2, 37:1.2, 39:1.2, 40:1.2, 42:1.2, 45:1.2, 47:1.2, 49:1.2, 50:1.2, 20:1.5, 22: 1.5, 25:1.5, 27:1.5, 30:1.5, 32:1.5, 35:1.5, 37:1.5, 39:1.5, 40:1.5, 42:1.5, 45:1.5, 47:1.5, 49:1.5, 50:1.5, 20:1.7, 22:1.7, 25:1.7, 27:1.7, 30:1.7, 32:1.7, 35:1.7, 37:1.7, 39:1.7, 40:1.7, 42:1.7, 45:1.7, 47:1.7, 49:1.7, 50:1.7, 20:2, 22:2, 25:2, 27:2, 30:2, 32:2, 35:2, 37:2, 39:2, 40:2, 42:2, 45:2, 47:2, 49:2, 50:2.

[0073] The present application also provides a method for preparing the above-mentioned nicotine liquid preparation, comprising the following steps: mixing nicotine, a nicotine head-feeling simulating additive, an atomizing solvent, and an organic acid, and then heating and stirring the mixture until uniform.

[0074] In some optional embodiments, the method for preparing the nicotine liquid preparation further comprises the step of adding flavoring.

[0075] This application does not impose any specific restrictions on the heating and stirring temperature and time, as long as the raw materials can be dissolved. Optionally, the dissolution temperature is not higher than 100°C. Optionally, the heating and stirring temperature is 40-65°C, and the heating and stirring time is 20-30 minutes. In this application, all the raw materials can be mixed and then heated to dissolve, or some of the raw materials can be mixed and dissolved first, and then the remaining raw materials can be mixed and dissolved. In some optional embodiments, the preparation method of the nicotine liquid preparation comprises the following steps: mixing nicotine, a nicotine head-feeling simulating additive, an organic acid and an atomizing solvent, heating at 40-65°C for 20-30 minutes to dissolve and mix evenly, and then adding flavoring at 10-40°C and stirring for 5-40 minutes to mix evenly to obtain the nicotine liquid preparation.

[0076] The present application also provides a use of the aforementioned nicotine liquid preparation or the nicotine liquid preparation prepared by the aforementioned preparation method in an atomization device. Optionally, the atomization device is an electronic atomization device.

[0077] Example 1

[0078] This embodiment provides a method for preparing a nicotine liquid preparation, comprising the following steps:

[0079] 2 g of nicotine was mixed with 1.50 g of benzoic acid, 0.1 g of cytisine, 0.3 g of magnolol, 11.1 g of propylene glycol, and 40 g of glycerol. The mixture was heated and stirred in a 60° C. water bath for 20 min to dissolve and mix uniformly. After cooling to room temperature, 45 g of blueberry flavor was added, and stirring was continued for 20 min to mix uniformly to obtain the nicotine liquid preparation.

[0080] Example 2

[0081] This embodiment provides a method for preparing a nicotine liquid preparation, comprising the following steps:

[0082] 2 g of nicotine was mixed with 1.50 g of benzoic acid, 0.7 g of cytisine, 0.3 g of magnolol, 10.5 g of propylene glycol, and 40 g of glycerol. The mixture was heated and stirred in a 60° C. water bath for 20 min to dissolve and mix uniformly. After cooling to room temperature, 45 g of blueberry flavor was added, and stirring was continued for 20 min to mix uniformly to obtain the nicotine liquid preparation.

[0083] Example 3

[0084] This embodiment provides a method for preparing a nicotine liquid preparation, comprising the following steps:

[0085] 2 g of nicotine was mixed with 1.50 g of benzoic acid, 1.5 g of cytisine, 0.3 g of magnolol, 9.7 g of propylene glycol, and 40 g of glycerol. The mixture was heated and stirred in a 60° C. water bath for 20 min to dissolve and mix uniformly. After cooling to room temperature, 45 g of blueberry flavor was added, and stirring was continued for 20 min to mix uniformly to obtain the nicotine liquid preparation.

[0086] Example 4

[0087] This embodiment provides a method for preparing a nicotine liquid preparation, comprising the following steps:

[0088] 2 g of nicotine was mixed with 1.50 g of benzoic acid, 2 g of cytisine, 0.3 g of magnolol, 9.2 g of propylene glycol, and 40 g of glycerol. The mixture was heated and stirred in a 60° C. water bath for 20 min to dissolve and mix uniformly. After cooling to room temperature, 45 g of blueberry flavor was added, and stirring was continued for 20 min to mix uniformly to obtain the nicotine liquid preparation.

[0089] Example 5

[0090] This embodiment provides a method for preparing a nicotine liquid preparation, comprising the following steps:

[0091] 2 g of nicotine was mixed with 1.50 g of benzoic acid, 2.0 g of cytisine, 1 g of magnolol, 8.5 g of propylene glycol, and 40 g of glycerol. The mixture was heated and stirred in a 60° C. water bath for 20 min to dissolve and mix uniformly. After cooling to room temperature, 45 g of blueberry flavor was added, and stirring was continued for 20 min to mix uniformly to obtain the nicotine liquid preparation.

[0092] Example 6

[0093] This embodiment provides a method for preparing a nicotine liquid preparation, comprising the following steps:

[0094] 2 g of nicotine was mixed with 1.50 g of benzoic acid, 0.4 g of cytisine, 0.3 g of magnolol, 0.3 g of 6-methylnicotine, 10.5 g of propylene glycol, and 40 g of glycerol. The mixture was heated and stirred in a 60° C. water bath for 20 min to dissolve and mix uniformly. After cooling to room temperature, 45 g of blueberry flavor was added, and stirring was continued for 20 min to mix uniformly to obtain the nicotine liquid preparation.

[0095] Example 7

[0096] This embodiment provides a method for preparing a nicotine liquid preparation, comprising the following steps:

[0097] 1.5 g of nicotine, 1.48 g of benzoic acid, 0.7 g of cytisine, 0.3 g of magnolol, 0.5 g of 6-methylnicotine, 10.52 g of propylene glycol, and 40 g of glycerol were mixed, heated and stirred in a 60° C. water bath for 20 min to dissolve and mix uniformly. After cooling to room temperature, 45 g of blueberry flavor was added, and stirring was continued for 20 min to mix uniformly to obtain the nicotine liquid preparation.

[0098] Example 8

[0099] This embodiment provides a method for preparing a nicotine liquid preparation, comprising the following steps:

[0100] 1.3 g of nicotine, 1.48 g of benzoic acid, 0.7 g of cytisine, 0.3 g of magnolol, 0.7 g of 6-methylnicotine, 10.52 g of propylene glycol, and 40 g of glycerol were mixed, heated and stirred in a 60° C. water bath for 20 minutes to dissolve and mix uniformly. After cooling to room temperature, 45 g of blueberry flavor was added, and stirring was continued for 20 minutes to mix uniformly to obtain the nicotine liquid preparation.

[0101] Example 9

[0102] This embodiment provides a method for preparing a nicotine liquid preparation, comprising the following steps:

[0103] 1.3 g of nicotine, 1.46 g of benzoic acid, 1.5 g of cytisine, 0.3 g of magnolol, 0.7 g of 6-methylnicotine, 9.74 g of propylene glycol, and 40 g of glycerol were mixed, heated and stirred in a 60° C. water bath for 20 min to dissolve and mix uniformly. After cooling to room temperature, 45 g of blueberry flavor was added, and stirring was continued for 20 min to mix uniformly to obtain the nicotine liquid preparation.

[0104] Example 10

[0105] This embodiment provides a method for preparing a nicotine liquid preparation, comprising the following steps:

[0106] 1.3 g of nicotine, 1.46 g of benzoic acid, 2.0 g of cytisine, 1.0 g of magnolol, 0.7 g of 6-methylnicotine, 8.54 g of propylene glycol, and 40 g of glycerol were mixed, heated and stirred in a 60° C. water bath for 20 min to dissolve and mix uniformly. After cooling to room temperature, 45 g of blueberry flavor was added, and stirring was continued for 20 min to mix uniformly to obtain the nicotine liquid preparation.

[0107] Example 11

[0108] This embodiment provides a method for preparing a nicotine liquid preparation, comprising the following steps:

[0109] 1.0 g of nicotine, 1.45 g of benzoic acid, 1.5 g of cytisine, 0.3 g of magnolol, 1.0 g of 6-methylnicotine, 9.75 g of propylene glycol, and 40 g of glycerol were mixed, heated and stirred in a 60° C. water bath for 20 min to dissolve and mix uniformly. After cooling to room temperature, 45 g of blueberry flavor was added, and stirring was continued for 20 min to mix uniformly to obtain the nicotine liquid preparation.

[0110] Example 12

[0111] This embodiment provides a method for preparing a nicotine liquid preparation, comprising the following steps:

[0112] 2 g of nicotine, 1.50 g of benzoic acid, 1 g of cytisine, 10.5 g of propylene glycol, and 40 g of glycerol were mixed, heated and stirred in a 60° C. water bath for 20 min to dissolve and mix uniformly. After cooling to room temperature, 45 g of blueberry flavor was added, and stirring was continued for 20 min to mix uniformly to obtain the nicotine liquid preparation.

[0113] Example 13

[0114] This embodiment provides a method for preparing a nicotine liquid preparation, comprising the following steps:

[0115] 2 g of nicotine, 1.50 g of benzoic acid, 1 g of magnolol, 10.5 g of propylene glycol, and 40 g of glycerol were mixed, heated and stirred in a 60° C. water bath for 20 min to dissolve and mix uniformly. After cooling to room temperature, 45 g of blueberry flavor was added, and stirring was continued for 20 min to mix uniformly to obtain the nicotine liquid preparation.

[0116] Comparative Example 1

[0117] This comparative example provides a method for preparing a nicotine liquid preparation, comprising the following steps:

[0118] 2.0 g of nicotine, 1.50 g of benzoic acid, 11.5 g of propylene glycol, and 40 g of glycerol were mixed, heated and stirred in a 60° C. water bath for 20 min to dissolve and mix uniformly. After cooling to room temperature, 45 g of blueberry flavor was added, and stirring was continued for 20 min to mix uniformly to obtain the nicotine liquid preparation.

[0119] Comparative Example 2

[0120] This comparative example provides a method for preparing a nicotine liquid preparation, comprising the following steps:

[0121] 3.0 g of nicotine, 2.26 g of benzoic acid, 9.74 g of propylene glycol, and 40 g of glycerol were mixed, heated and stirred in a 60° C. water bath for 20 min to dissolve and mix uniformly. After cooling to room temperature, 45 g of blueberry flavor was added, and stirring was continued for 20 min to mix uniformly to obtain the nicotine liquid preparation.

[0122] Comparative Example 3

[0123] This comparative example provides a method for preparing a nicotine liquid preparation, comprising the following steps:

[0124] 4.0 g of nicotine, 3 g of benzoic acid, 8.0 g of propylene glycol, and 40 g of glycerol were mixed, heated and stirred in a 60° C. water bath for 20 min to dissolve and mix uniformly. After cooling to room temperature, 45 g of blueberry flavor was added, and stirring was continued for 20 min to mix uniformly to obtain the nicotine liquid preparation.

[0125] Comparative Example 4

[0126] This comparative example provides a method for preparing a nicotine liquid preparation, comprising the following steps:

[0127] 5.0 g of nicotine, 3.76 g of benzoic acid, 6.24 g of propylene glycol, and 40 g of glycerol were mixed, heated and stirred in a 60° C. water bath for 20 minutes to dissolve and mix uniformly. After cooling to room temperature, 45 g of blueberry flavor was added, and stirring was continued for 20 minutes to mix uniformly to obtain the nicotine liquid preparation.

[0128] Test Case

[0129] This application uses a subjective smoking method to score various smoking indicators of the nicotine liquid preparations of Examples 1-13 and Comparative Examples 1-4. The smoking team consists of 12 people, all of whom have more than 5 years of traditional cigarette smoking experience or more than 3 years of e-cigarette smoking experience and have undergone nicotine withdrawal 12 hours before smoking.

[0130] Each smoker completed a smoke evaluation form and used a blind scoring method. Different examples and comparative examples were randomly coded with three-digit numbers. The evaluators began smoking at 10:00 AM and continued to smoke the next random sample after an interval of one hour. The smoke evaluation method was as follows: During each sample, smokers took a total of eight puffs (3 seconds per puff, with a 27-second interval between each puff). The smoke remained in the mouth for a short time before being swallowed into the lungs. Smokers were not allowed to discuss their experience. They each scored their evaluation according to the evaluation criteria in Table 1 and recorded their results on the smoke evaluation form. The test results are shown in Table 2 (the scoring value is the average score).

[0131] Table 1 Evaluation indicators

[0132] Table 2 Product absorption scoring data

[0133] Heart rate testing was performed during the smoking process on the nicotine liquid preparations prepared in Examples 2, 6, 12, 13, and Comparative Example 1 (hereinafter referred to as "samples"). The testing method was as follows: the smokers underwent nicotine withdrawal the night before the smoking test and underwent the smoking process heart rate test at 9:00 AM on the day of the smoking test. Before smoking, the heart rate monitoring device (the Lepu Xinanbao ER1) was worn, and the real-time changes in heart rate were monitored throughout the smoking process. After the heart rate device was worn and debugged, a 2-minute baseline heart rate test was performed. After the heart rate stabilized, heart rate monitoring during the smoking process began. Using a RELX5 cigarette holder (with samples from different Examples and Comparative Examples), a total of 5 puffs of smoke were taken (3 seconds per puff, with a 27-second interval between adjacent puffs). The total smoking time was approximately 2.5 minutes, and the start time of each puff was recorded. After the smoking was completed, the heart rate changes were monitored for an additional 1 minute, and then the experiment was terminated. After finishing one sample, abstain from smoking for 2 hours before repeating the heart rate test for the next sample. The test results are shown in Figures 1 and 2. The normalized heart rate in Figure 1 is the ratio of the real-time monitored heart rate during smoking to the average baseline heart rate over the 2-minute period, while the average normalized heart rate in Figure 2 is the ratio of the average monitored heart rate during smoking to the average baseline heart rate.

[0134] Obviously, the above embodiments are merely examples for clarity of explanation and are not intended to limit the implementation methods. Those skilled in the art will readily appreciate that other variations or modifications based on the above descriptions are possible. It is not necessary and impossible to enumerate all implementation methods here. Obvious variations or modifications arising therefrom remain within the scope of protection of the present invention.

Claims

1. A nicotine liquid preparation, characterized in that, the raw material components of the nicotine liquid preparation include nicotine, a nicotine head rush simulation additive, an atomization solvent, and an organic acid; the nicotine head rush simulation additive is selected from at least one of cytisine, magnolol, and 6-methylnicotine; the nicotine content in the nicotine liquid preparation is 10-20 mg / g.

2. The nicotine liquid preparation according to claim 1, characterized in that, the mass ratio of the nicotine head rush simulation additive to nicotine is (0.1-3.7):(1-2); optionally, the mass ratio of the nicotine head rush simulation additive to nicotine is (1-3.7):(1-2).

3. The nicotine liquid preparation according to claim 1 or 2, characterized in that, the nicotine head rush simulation additive is selected from at least two of cytisine, magnolol, and 6-methylnicotine.

4. The nicotine liquid preparation according to any one of claims 1-3, characterized in that, the nicotine head rush simulation additive is cytisine and magnolol; the mass ratio of cytisine to magnolol is (1-20):(1-10); optionally, the mass of cytisine accounts for 0.1-2% of the mass of the nicotine liquid preparation; the mass of magnolol accounts for 0.1-1% of the mass of the nicotine liquid preparation.

5. The nicotine liquid preparation according to any one of claims 1-3, characterized in that, the nicotine head rush simulation additive is cytisine, magnolol, and 6-methylnicotine; the mass ratio of cytisine, magnolol, and 6-methylnicotine is (1-20):(1-10):(1-10); optionally, the mass of cytisine accounts for 0.1-2% of the mass of the nicotine liquid preparation; the mass of magnolol accounts for 0.1-1% of the mass of the nicotine liquid preparation; the mass of 6-methylnicotine accounts for 0.1-1% of the mass of the nicotine liquid preparation.

6. The nicotine liquid preparation according to any one of claims 1-5, characterized in that, the mass ratio of the atomization solvent to nicotine is (40-97.8):(1-2).

7. The nicotine liquid preparation according to any one of claims 1-6, characterized in that, the atomization solvent includes at least one of propylene glycol, glycerol, water, ethanol, triacetin, and sorbitol.

8. The nicotine liquid preparation according to any one of claims 1-7, characterized in that, the atomization solvent is propylene glycol and glycerol; the mass ratio of propylene glycol to glycerol is (1-50):(1-50).

9. The nicotine liquid preparation according to any one of claims 1-8, characterized in that, the organic acid includes at least one of C3-C8 organic carboxylic acids; optionally, the organic acid includes at least one of C3-C8 monobasic organic carboxylic acids, C3-C8 dibasic organic carboxylic acids, and C3-C8 tribasic organic carboxylic acids.

10. The nicotine liquid preparation according to any one of claims 1-9, characterized in that, The organic acid includes at least one of salicylic acid, citric acid, malic acid, benzoic acid, levulinic acid, tartaric acid, and succinic acid; Optionally, the organic acid is benzoic acid.

11. The nicotine liquid preparation according to any one of claims 1-10, characterized in that Calculated by carboxyl group, the molar ratio of the organic acid to nicotine is (1-2):(1-2); Optionally, calculated by carboxyl group, the molar ratio of the organic acid to nicotine is 1:

1.

12. The nicotine liquid preparation according to any one of claims 1-10, characterized in that Calculated by carboxyl group, the total molar amount of nicotine and 6-methylnicotine and the molar amount of the organic acid is (0.98-2):(0.98-2); Optionally, calculated by carboxyl group, the total molar amount of nicotine and 6-methylnicotine and the molar amount of the organic acid is 1:

1.

13. The nicotine liquid preparation according to any one of claims 1-12, characterized in that The raw material components of the nicotine liquid preparation further include essence.

14. The nicotine liquid preparation according to claim 13, characterized in that The essence includes at least one of tobacco essence, fruit essence, and mint essence; Optionally, the fruit essence includes at least one of blueberry essence, strawberry essence, and watermelon essence.

15. The nicotine liquid preparation according to any one of claims 13-14, characterized in that The mass ratio of the essence to nicotine is (20-50):(1-2).

16. A method for preparing the nicotine liquid preparation according to any one of claims 1-15, characterized in that comprises the following steps: Mix nicotine, nicotine head-feeling simulation additive, atomization solvent and organic acid, and then heat and stir evenly to obtain.

17. The method for preparing the nicotine liquid preparation according to claim 16, characterized in that It further includes the step of adding essence.

18. Application of the nicotine liquid preparation according to any one of claims 1-15 or the nicotine liquid preparation prepared by the preparation method according to any one of claims 16 or 17 in an atomization device.

19. The application according to claim 18, characterized in that The atomization device is an electronic atomization device.

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