Calibration method and sample analysis system

Abstract

A calibration method and a sample analysis system. The method comprises: evaluating calibration states of detection reagents; and for a target detection reagent of which the calibration state conforms to a preset state, generating a calibration task for the target detection reagent by a control device of a sample analyzer. The calibration task can be generated in a timely manner for the target detection reagent of which the calibration state conforms to the preset state, without the need for a user to check which detection reagents need to be calibrated, and without the need for the user to manually generate a calibration task, thereby reducing user operations, and facilitating improvement of the timeliness of calibration for the detection reagents.

Description

Calibration methods and sample analysis systems

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS

[0002] The present invention claims priority to Chinese patent application CN202311792122.4, filed on December 22, 2023, entitled “Calibration Method and Sample Analysis System,” the entire contents of which are incorporated herein by reference. Technical Field

[0003] The present invention relates to the field of control technology, and in particular to a calibration method and a sample analysis system. Background Art

[0004] In related technologies, a sample analyzer is an instrument that uses test reagents to analyze blood samples. During the test, the concentration of the substance to be tested is determined using a test reagent corresponding to the substance to be tested in the blood sample. The test reagent mixes with the blood sample, producing a biochemical reaction that emits a light signal. The intensity of this light signal reflects the concentration of the substance to be tested. The concentration of the substance to be tested in the blood sample can be calculated using a conversion curve stored in the sample analyzer between the light signal intensity and the concentration of the substance to be tested.

[0005] The conversion curve is obtained by using a detection reagent to detect multiple calibrators of different standard concentrations. This process can be regarded as calibration of the detection reagent. When calibrating the detection reagent, a calibrator of known concentration is mixed with the detection reagent to generate a light signal, and the generated light signal is used as the standard signal value corresponding to the concentration of the calibrator. By using the detection reagent to sequentially detect calibrators of different concentration gradients to obtain a corresponding multiple light signal intensity values, these multiple light signal intensity values ​​are the light signal intensity values ​​generated when the detection reagent detects different concentrations of the test sample, thereby obtaining a conversion curve between the light signal intensity value and the concentration of the test sample. The obtained conversion curve is also called a calibration curve.

[0006] All detection reagents used in the sample analyzer must be calibrated before they can be used normally for testing the samples to be tested. Moreover, the calibration curve is not valid for a long time. Usually, a single calibration can only guarantee the validity of the test results within a certain period of time, such as 28 days. After the validity period of the calibration curve has expired, the same detection reagent needs to be calibrated again. In related technologies, users are required to manually check and identify which detection reagents need to be calibrated, manually generate and execute calibration tasks, which is cumbersome to operate, has a poor user experience, and cannot calibrate the detection reagents in a timely manner.

[0007] Therefore, a new calibration method is needed.

[0008] Summary of the Invention

[0009] The main purpose of the present invention is to provide a calibration method and a sample analysis system to achieve automatic calibration of detection reagents.

[0010] The present invention provides a calibration method for a sample analyzer that uses a detection reagent to detect the concentration of a specific substance in a blood sample, comprising: obtaining calibration information of the detection reagent loaded in a reagent compartment of the sample analyzer, and evaluating the calibration status of the detection reagent based on the calibration information; for a target detection reagent whose calibration status meets a preset status, a control device of the sample analyzer generates a calibration task for the target detection reagent.

[0011] In one embodiment, the method further includes: obtaining identification information of the detection reagent loaded in the reagent compartment of the sample analyzer through an identification reading device, and / or retrieving identification information of the detection reagent loaded in the reagent compartment of the sample analyzer from a database; obtaining calibration information of the detection reagent loaded in the reagent compartment of the sample analyzer includes: retrieving calibration information of the detection reagent loaded in the reagent compartment of the sample analyzer from a database according to the identification information.

[0012] In one embodiment, when a preset trigger event occurs, the calibration information of the detection reagent loaded in the reagent chamber of the sample analyzer is retrieved from the database based on the identification information, wherein the preset trigger event includes at least one of the following: obtaining the identification information of the detection reagent loaded in the reagent chamber of the sample analyzer for the first time after receiving the start signal of the control software; obtaining the identification information of the detection reagent loaded in the reagent chamber of the sample analyzer for the first time after receiving the power-on signal of the sample analyzer or after receiving the enable signal for switching the sample analyzer to an enable state; receiving a loading signal for newly loading the detection reagent in the reagent chamber of the sample analyzer; and receiving an enable signal for switching the detection reagent in the reagent chamber of the sample analyzer to an enable state.

[0013] In one embodiment, the calibration information includes a calibration curve for the detection reagent and the validity period of the calibration curve; the calibration status of the detection reagent is evaluated based on the calibration information, including: when the calibration curve is included in the calibration information and the validity period of the calibration curve is greater than 0 and does not exceed a preset time period, the calibration status of the detection reagent is evaluated as being about to expire; when the calibration curve is included in the calibration information and the validity period of the calibration curve does not exceed 0, or when the calibration curve is not included in the calibration information, the calibration status of the detection reagent is evaluated as invalid; the preset status includes at least one of the following: about to expire and invalid.

[0014] In one embodiment, for the target detection reagent whose calibration status meets the preset status, the control device of the sample analyzer generates a calibration task for the target detection reagent, including: when the calibration status is invalid, the control device of the sample analyzer generates a first calibration task for the target detection reagent; and / or when the calibration status is about to expire, the control device of the sample analyzer generates a second calibration task for the target detection reagent.

[0015] In one embodiment, the method further includes: after generating the second calibration task, monitoring the remaining validity period of the target detection reagent, and when the remaining validity period is equal to 0, switching the second calibration task of the target detection reagent to the first calibration task.

[0016] In one embodiment, the method further includes: when generating the first calibration task, setting the available status of the detection reagents having the same identification information as the target detection reagent corresponding to the first calibration task to a disabled status.

[0017] In one embodiment, it also includes: based on the first calibration task and / or the second calibration task to be executed, retrieving the standard samples and their position information corresponding to the first calibration task and / or the second calibration task loaded in the sample bin from the database; calling the standard samples according to the position information of the standard samples, executing the corresponding first calibration task and / or the second calibration task, and generating calibration information of the target detection reagent corresponding to the first calibration task and / or the second calibration task.

[0018] In one embodiment, the position information of the newly loaded standard sample in the sample chamber is acquired by a label reading device, and the position information of the newly loaded standard sample is associated with the corresponding standard sample and stored in the database.

[0019] In one embodiment, the calibration method is performed according to a preset period.

[0020] The present invention provides a sample analysis system, comprising: a computing device including a processor and a memory, wherein a computer program is stored in the memory, and when the computer program is executed by the processor, the steps of the above-mentioned calibration method are implemented; and at least one sample analyzer is used to perform calibration tasks according to control instructions of the computing device.

[0021] Through the calibration method of the present invention, calibration tasks can be generated in a timely manner for target detection reagents whose calibration status meets the preset status. There is no need for users to check which detection reagents need to be calibrated by themselves, nor is there a need for users to manually generate calibration tasks, which reduces user operations and is conducive to improving the timeliness of calibration of detection reagents. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] The accompanying drawings, which constitute a part of the present application, are intended to provide a further understanding of the present invention. The exemplary embodiments of the present invention and their descriptions are intended to explain the present invention and do not constitute an improper limitation of the present invention. In the accompanying drawings:

[0023] FIG1 is a flow chart of a calibration method according to an embodiment of the present application;

[0024] FIG2 is a schematic diagram of a calibration task display interface according to an embodiment of the present application;

[0025] FIG3 is a schematic diagram of a control for controlling execution of a calibration task on a calibration task display interface according to an embodiment of the present application;

[0026] FIG4 is a schematic structural diagram of a calibration system according to an embodiment of the present application. DETAILED DESCRIPTION

[0027] It should be noted that, in the absence of conflict, the embodiments and features of the embodiments in this application can be combined with each other. The present invention will be described in detail below with reference to the accompanying drawings and in combination with the embodiments.

[0028] In the related art, the calibration of the detection reagent is carried out according to the following steps:

[0029] 1. The user checks which test reagents on the sample analyzer need to be calibrated;

[0030] 2. The user manually adds the calibration task to be performed in the calibration interface of the software;

[0031] 3. After adding the calibration task, the user switches to the work order interface and places the corresponding calibration products in the designated location;

[0032] 4. The user manually clicks Submit;

[0033] 5. The sample analyzer performs the submitted calibration task;

[0034] 6. Generate a calibration curve after the calibration task is completed.

[0035] In the related art, users are required to personally check and determine which detection reagents need to be calibrated. For detection reagents that need to be calibrated, most steps of the calibration operation need to be performed by the user personally. The process is cumbersome, neither intelligent nor convenient, and the user experience is poor.

[0036] 1 , this embodiment provides a calibration method for a sample analyzer that uses a detection reagent to detect the concentration of a specific substance in a blood sample, which may include: obtaining calibration information of the detection reagent loaded in a reagent compartment of the sample analyzer, and evaluating the calibration status of the detection reagent based on the calibration information; for a target detection reagent whose calibration status meets a preset status, a control device of the sample analyzer generates a calibration task for the target detection reagent.

[0037] The sample analyzer can be a biochemical analyzer, a chemiluminescence analyzer, a cell analyzer, a urine analyzer, a coagulation analyzer, and the like. Furthermore, the sample analyzer can be a sample analyzer based on different detection methodologies, such as a biochemical analyzer based on latex turbidimetric detection, a chemiluminescence analyzer based on enzyme-linked immunosorbent assay, and a chemiluminescence analyzer based on photochemiluminescence. The control device of the sample analyzer may include one or more terminal devices, and each terminal device may control one or more sample analyzers. The terminal device may include any computing device with computing functions, such as a desktop computer, a laptop computer, a tablet computer, a mobile phone, etc. The method of the present invention can be applied to a sample analyzer, and can also be applied to other analytical detection instruments that require calibration of the detection reagents, and this application does not make specific limitations on this. Data communication connections between the terminal device and the sample analyzer, and between multiple terminal devices can be made in wired or wireless form through a local area network or a wide area network, and those skilled in the art can make specific settings as needed.

[0038] In the present embodiment, the calibration state of the detection reagent can be manually assessed, the calibration state of the detection reagent can be assessed according to the category of the detection reagent, and the calibration state of the detection reagent can also be assessed according to the loading time of the detection reagent, which is not limited here. The calibration state of the detection reagent can include, for example, about to be effective, effective, about to expire and invalid, etc., and the preset state can include, for example, about to be effective, expired and invalid, etc., and the present application is not limited thereto. The control device of the sample analyzer generates a calibration task for the target detection reagent, for example, it can generate a calibration task to be performed in the operating interface of the software, or it can directly generate a work order for the calibration task, which is not limited here.

[0039] In this embodiment, the calibration information of the detection reagent may include, for example, the number of the person who calibrated the detection reagent, the calibration date, the batch code of the standard sample used for calibration, etc., and may also include the calibration curve of the detection reagent and the validity period of the calibration curve, etc. The calibration status of the detection reagent is evaluated based on the calibration information. For example, the calibration status of detection reagents with certain batch codes may be specified as invalid, while the calibration status of detection reagents with certain person numbers may be specified as valid, etc., which are not limited here.

[0040] Through the calibration method of this embodiment, calibration tasks can be generated in a timely manner for target detection reagents whose calibration status meets the preset status. There is no need for users to check which detection reagents need to be calibrated by themselves, nor is there a need for users to manually generate calibration tasks, which reduces user operations and is conducive to improving the timeliness of calibration of detection reagents.

[0041] In one embodiment, the method may further include: retrieving calibration information of the detection reagent loaded in the reagent compartment of the sample analyzer from a database, and evaluating the calibration status of the detection reagent based on the calibration information.

[0042] In one embodiment, the method may further include: obtaining identification information of the detection reagent loaded in the reagent compartment of the sample analyzer through an identification reading device, and / or retrieving identification information of the detection reagent loaded in the reagent compartment of the sample analyzer from a database; obtaining calibration information of the detection reagent loaded in the reagent compartment of the sample analyzer, including: retrieving calibration information of the detection reagent loaded in the reagent compartment of the sample analyzer from the database according to the identification information.

[0043] In this embodiment, the identification information may include information indicating the production batch, manufacturer, place of origin, etc. of the detection reagent. For example, the identification information may be a batch code, etc. Even for detection reagents with the same composition, detection reagents with different batch codes may need to be calibrated separately. For detection reagents newly loaded in the reagent compartment of the sample analyzer, the identification information of the newly loaded detection reagents can be obtained through the identification reading device; for detection reagents originally loaded in the reagent compartment of the sample analyzer, it is possible that the identification information of these detection reagents has been read when these detection reagents were first loaded into the reagent compartment of the sample analyzer, so that the identification information of these detection reagents can be directly retrieved from the database, or the identification information of these detection reagents can be read through the identification reading device, which is not limited here.

[0044] In this embodiment, the identification information of the detection reagent can be obtained by scanning the barcode, QR code and other label information of the detection reagent loaded in the reagent compartment by an identification reading device, wherein the identification reading device may include, for example, a barcode scanner; the calibration information of the detection reagent can be obtained by scanning the barcode, QR code and other methods of the detection reagent, or the calibration information of the detection reagent can be directly retrieved from the database according to the identification information of the detection reagent, which is not specifically limited here.

[0045] In one embodiment, when a preset trigger event occurs, the calibration information of the detection reagent loaded in the reagent chamber of the sample analyzer is retrieved from the database based on the identification information, wherein the preset trigger event includes at least one of the following: obtaining the identification information of the detection reagent loaded in the reagent chamber of the sample analyzer for the first time after receiving the start signal of the control software; obtaining the identification information of the detection reagent loaded in the reagent chamber of the sample analyzer for the first time after receiving the power-on signal of the sample analyzer or after receiving the enable signal for switching the sample analyzer to an enable state; receiving a loading signal for newly loading the detection reagent in the reagent chamber of the sample analyzer; and receiving an enable signal for switching the detection reagent in the reagent chamber of the sample analyzer to an enable state.

[0046] In this embodiment, when the control software, sample analyzer, and detection reagents are newly activated or reactivated, the calibration information of the detection reagents is promptly retrieved and the calibration status of the detection reagents is evaluated. This facilitates timely detection of whether the detection reagents loaded on the sample analyzer need to be calibrated and timely generation of corresponding calibration tasks, thereby preparing for subsequent detection and analysis of the test samples, facilitating the normal detection and analysis of the sample analyzer, and improving the accuracy of the detection and analysis results. The control software may include software that controls the sample analyzer, which may be system software or application software, and is not limited here.

[0047] In one embodiment, the calibration information may include a calibration curve for the detection reagent and the validity period of the calibration curve; evaluating the calibration status of the detection reagent based on the calibration information may include: when the calibration information includes a calibration curve and the validity period of the calibration curve is greater than 0 and does not exceed a preset time period, evaluating the calibration status of the detection reagent as being about to expire; when the calibration information includes a calibration curve and the validity period of the calibration curve does not exceed 0, or when the calibration information does not include a calibration curve, evaluating the calibration status of the detection reagent as invalid; the preset status may include at least one of the following: about to expire and invalid.

[0048] Among them, the preset duration can be set by the user according to needs, for example, it can be 2 days, 10 days, etc., and this application does not make specific limitations on this.

[0049] In this embodiment, the validity period of the calibration curve is greater than 0 and less than the preset time length, indicating that the validity period of the calibration curve is short, so the calibration status of the detection reagent can be evaluated as about to expire; when the validity period of the calibration curve is less than or equal to 0, it means that the calibration curve has expired, so the calibration status of the detection reagent can be evaluated as invalid.

[0050] In other embodiments, the calibration status of the detection reagent can also be evaluated in other ways. For example, the calibration status of the detection reagent can be evaluated based on the batch code of the detection reagent, and certain specific batches of detection reagents can be evaluated as valid or invalid. This application does not limit this.

[0051] In one embodiment, for a target detection reagent whose calibration state conforms to a preset state, the control device of the sample analyzer generates a calibration task for the target detection reagent, which may include: when the calibration state is invalid, the control device of the sample analyzer generates a first calibration task for the target detection reagent; and / or when the calibration state is about to expire, the control device of the sample analyzer generates a second calibration task for the target detection reagent.

[0052] In this embodiment, a first calibration task is generated for an invalid detection reagent, and the first calibration task indicates that the detection reagent needs to be calibrated immediately, otherwise the detection result using the detection reagent is inaccurate. In one embodiment, when the first calibration task is generated, the available status of the detection reagents with the same identification information as the target detection reagent corresponding to the first calibration task can be set to a disabled state. A second calibration task is generated for the detection reagent that is about to expire, and the second calibration task indicates that the detection reagent is currently available, but needs to be calibrated within a certain time, otherwise it becomes unavailable after the time.

[0053] Simply put, the first calibration task takes priority over the second calibration task. Therefore, when scheduling calibration tasks, the first calibration task is prioritized to make any disabled test reagents available. After all available first calibration tasks are completed, the second calibration task is executed to extend the life of the calibration curve that is about to expire.

[0054] In this embodiment, different calibration tasks are generated for different calibration states of the target detection reagents, which is conducive to reasonably arranging the calibration order of the target detection reagents according to different calibration urgency levels and is conducive to orderly sample detection by the sample analyzer.

[0055] In specific operations, when the sample analyzer is idle, for example, after completing the daily startup routine maintenance procedure, or when the sample analyzer does not receive a new detection task, the sample analyzer automatically enters the calibration procedure to automatically execute the unfinished calibration task.

[0056] Continuing with reference to FIG1 , in one embodiment, after the second calibration task is generated, the remaining validity period of the target detection reagent is monitored, and when the remaining validity period is equal to 0, the second calibration task of the target detection reagent is switched to the first calibration task.

[0057] In this embodiment, for the detection reagent whose calibration curve is about to expire, after generating the second calibration task, the remaining validity period of the detection reagent can continue to be monitored. When the remaining validity period of the calibration curve is equal to 0, the second calibration task is promptly converted into the first calibration task to increase the urgency of the calibration task.

[0058] In one embodiment, the method may also include: based on the first calibration task and / or the second calibration task to be executed, retrieving the standard samples and their position information corresponding to the first calibration task and / or the second calibration task loaded in the sample bin from the database; calling the standard samples according to the position information of the standard samples, executing the corresponding first calibration task and / or the second calibration task, and generating calibration information of the target detection reagent corresponding to the first calibration task and / or the second calibration task.

[0059] In this embodiment, the sample bin can be the sample bin of the sample manager or the sample bin of the sample analyzer. When one control device controls multiple sample analyzers, multiple sample analyzers can share the sample bin of one sample manager, or each sample analyzer can have its own sample bin.

[0060] For example, based on the target detection reagent corresponding to the first calibration task, the database can be retrieved for the standard sample corresponding to the target detection reagent loaded in the sample compartment and its location information. Then, based on the location information of the standard sample, the first calibration task is executed and calibration information of the target detection reagent, such as a calibration curve and the validity period of the calibration curve, is generated. The second calibration task can be executed in the same manner and will not be described in detail here.

[0061] In this embodiment, by retrieving the position information of the standard sample from the database, the calibration task is automatically executed, eliminating the trouble of manual operation and improving the detection efficiency.

[0062] In one embodiment, the position information of the newly loaded standard sample in the sample chamber is acquired by a label reading device, and the position information of the newly loaded standard sample is associated with the corresponding standard sample and stored in the database.

[0063] In this embodiment, the tag reading device and the identification reading device may be the same device or two devices, and may be the same device or different devices.

[0064] In one embodiment, the calibration method of the present invention may be performed according to a preset period, which may be, for example, 1 day, 3 days, 10 days, 15 days, etc., but the present application is not limited thereto.

[0065] By performing calibration tasks regularly, the detection reagents can be calibrated in a timely manner, which is conducive to the smooth and efficient implementation of sample testing.

[0066] Referring to Figure 2, in one embodiment, when the first calibration task and the second calibration task are generated at the same time, the display device can be controlled to display the first calibration task and the second calibration task at the same time, and the first calibration task can be displayed before the second calibration task to reflect that the urgency of the first calibration task is greater than that of the second calibration task. In Figure 2, the content displayed by the display device includes information such as the project name, reagent batch number, calibration reason, calibration (sample) batch number, and module name. In other embodiments, more or less information can be displayed, and this application does not make specific limitations on this. Figure 3 is a schematic diagram of the control for controlling the execution of the calibration task on the calibration task display interface. The control shown in Figure 3 is only an example, and the control can also have other appearances.

[0067] This embodiment provides a calibration device, including: a status evaluation module, used to evaluate the calibration status of a detection reagent; and a task generation module, used to generate a calibration task for a target detection reagent whose calibration status meets a preset status by a control device of the sample analyzer.

[0068] The calibration device of this embodiment may further include a processor and a memory, wherein the processor is configured to execute the aforementioned program modules stored in the memory, so as to automatically generate calibration tasks for target detection reagents in a timely manner.

[0069] This embodiment provides a computing device, including a processor and a memory, wherein a computer program is stored in the memory. When the computer program is executed by the processor, the steps of the above-mentioned calibration method are implemented.

[0070] In one embodiment, the computing device may include one or more processors (CPUs), input / output interfaces, network interfaces, and memory.

[0071] Memory may include non-permanent storage in a computer-readable medium, random access memory (RAM) and / or non-volatile memory in the form of read-only memory (ROM) or flash memory (FLASH RAM). Memory is an example of a computer-readable medium.

[0072] This embodiment provides a computer-readable storage medium, in which a computer program is stored. When the computer program is executed by a processor, the steps of the above-mentioned calibration method are implemented.

[0073] The computer program may be implemented in any combination of one or more storage media, which may be readable signal media or readable storage media.

[0074] The readable storage medium may include, for example, an electrical, magnetic, optical, electromagnetic, infrared, or semiconductor system, device, or device, or any combination thereof. More specific examples of readable storage media (a non-exhaustive list) may include: an electrical connection having one or more conductors, a portable disk, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber, a portable compact disk read-only memory (CD-ROM), an optical storage device, a magnetic storage device, or any suitable combination thereof.

[0075] A readable signal medium may include a data signal propagated in baseband or as part of a carrier wave, which carries a readable computer program. This propagated data signal may take a variety of forms, including, for example, electromagnetic signals, optical signals, or any suitable combination thereof. A readable signal medium may also be any storage medium other than a readable storage medium that can transmit, propagate, or transfer a program for use by or in conjunction with an instruction execution system, apparatus, or device.

[0076] The computer program contained on the storage medium may be transmitted using any appropriate medium, including wireless, wired, optical cable, RF, etc., or any suitable combination of the above.

[0077] The computer program for performing the operations of the present invention may be written in any combination of one or more programming languages. The programming languages ​​may include object-oriented programming languages, such as Java, C++, and the like, and may also include conventional procedural programming languages, such as "C" or similar programming languages. The computer program may be executed entirely on the user computing device, partially on the user device, or entirely on a remote computing device or server. In cases involving a remote computing device, the remote computing device may be connected to the user computing device via any type of network (e.g., a local area network or a wide area network), or may be connected to an external computing device (e.g., via the Internet using an Internet service provider).

[0078] This embodiment provides a sample analysis system, which may include: the computing device described above and at least one sample analyzer, wherein the sample analyzer is configured to execute a calibration task according to control instructions of the computing device to calibrate a target detection reagent to be calibrated.

[0079] Referring to Figure 4, in one embodiment, the sample analysis system can be composed of a host computer, a sample manager, and four sample analyzers. The host computer can communicate with the sample manager and each sample analyzer separately, and control the sample manager and each sample analyzer separately so that each sample analyzer executes the calibration task generated by the host computer.

[0080] Among them, the sample bin of the sample manager can be loaded with standard samples, and the standard samples in the sample manager can be distributed to the target sample analyzers among multiple sample analyzers through devices such as tracks, slides, and conveyor belts, and the target sample analyzers perform calibration tasks.

[0081] It should be noted that the terms used herein are only for describing specific embodiments and are not intended to limit the exemplary embodiments according to the present application. When the terms "include" and / or "include" are used in this specification, they indicate the presence of features, steps, operations, devices, components and / or their combinations.

[0082] It should be noted that the terms "first," "second," etc. in the specification, claims, and drawings of this application are used to distinguish similar objects, and are not used to describe a specific order or sequence. It should be understood that the terms used in this manner are interchangeable under appropriate circumstances.

[0083] It should be understood that the exemplary embodiments in this specification can be implemented in a variety of different forms and should not be construed as being limited to the embodiments described herein. Additionally or alternatively, certain steps may be omitted, multiple steps may be combined into a single step, and / or a single step may be broken down into multiple steps. These embodiments are provided to make the disclosure of this application thorough and complete, and to fully convey the concepts of these exemplary embodiments to those of ordinary skill in the art, and should not be construed as limiting the present invention.

[0084] Although the spirit and principles of the present invention have been described with reference to several specific embodiments, it should be understood that the present invention is not limited to the specific embodiments disclosed, and the division into various aspects does not mean that the features of these aspects cannot be combined to benefit. Such division is only for the convenience of expression. The present invention is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the appended claims.

Claims

1. A calibration method for a sample analyzer that uses a detection reagent to detect the concentration of a specific substance in a blood sample, characterized in that: include: Acquiring calibration information of a detection reagent loaded in a reagent compartment of a sample analyzer, and evaluating a calibration status of the detection reagent according to the calibration information; For the target detection reagent whose calibration state conforms to the preset state, the control device of the sample analyzer generates a calibration task for the target detection reagent.

2. The calibration method according to claim 1, characterized in that: Also includes: Obtaining identification information of the detection reagent loaded in the reagent compartment of the sample analyzer through an identification reading device, and / or retrieving identification information of the detection reagent loaded in the reagent compartment of the sample analyzer from a database; Obtain calibration information of the test reagents loaded in the reagent compartment of the sample analyzer, including: The calibration information of the detection reagent loaded in the reagent compartment of the sample analyzer is retrieved from the database according to the identification information.

3. The calibration method according to claim 2, characterized in that: In the event of a preset trigger event, the calibration information of the detection reagent loaded in the reagent compartment of the sample analyzer is retrieved from the database according to the identification information, wherein the preset trigger event includes at least one of the following: After receiving a start signal from the control software, obtaining identification information of the detection reagent loaded in the reagent compartment of the sample analyzer for the first time; After receiving a power-on signal of the sample analyzer or after receiving an activation signal for the sample analyzer to switch to an activation state, obtaining identification information of a detection reagent loaded in a reagent compartment of the sample analyzer for the first time; receiving a loading signal for newly loading a detection reagent into a reagent compartment of a sample analyzer; and An activation signal is received to switch the detection reagent in the reagent compartment of the sample analyzer to an activation state.

4. The calibration method according to claim 1, characterized in that: The calibration information includes a calibration curve for the detection reagent and the validity period of the calibration curve; Evaluating the calibration status of the detection reagent according to the calibration information includes: When the calibration information includes a calibration curve and the validity period of the calibration curve is greater than 0 and does not exceed a preset time period, evaluating the calibration status of the detection reagent as being about to expire; When the calibration information includes a calibration curve and the validity period of the calibration curve does not exceed 0, or when the calibration information does not include a calibration curve, evaluating the calibration status of the detection reagent as invalid; The preset state includes at least one of the following: about to expire and invalid.

5. The calibration method according to claim 4, characterized in that: For the target detection reagent whose calibration state meets the preset state, the control device of the sample analyzer generates a calibration task for the target detection reagent, including: In the case where the calibration state is invalid, the control device of the sample analyzer generates a first calibration task for the target detection reagent; and / or When the calibration status is about to fail, the control device of the sample analyzer generates a second calibration task for the target detection reagent.

6. The calibration method according to claim 5, characterized in that: Also includes: After the second calibration task is generated, the remaining validity period of the target detection reagent is monitored, and when the remaining validity period is equal to 0, the second calibration task of the target detection reagent is switched to the first calibration task.

7. The calibration method according to claim 5 or 6, characterized in that: Also includes: When the first calibration task is generated, the available states of the detection reagents having the same identification information as the target detection reagent corresponding to the first calibration task are all set to a disabled state.

8. The calibration method according to claim 5 or 6, characterized in that: Also includes: Based on the first calibration task and / or the second calibration task to be performed, retrieving the standard samples and their position information corresponding to the first calibration task and / or the second calibration task loaded in the sample bin from the database; Call the standard sample according to the position information of the standard sample, execute the corresponding first calibration task and / or the second calibration task, and generate a calibration task corresponding to the first calibration task and / or the second calibration task. Calibration information for the corresponding target detection reagents.

9. The calibration method according to claim 8, characterized in that: The position information of the newly loaded standard sample in the sample chamber is acquired by a label reading device, and the position information of the newly loaded standard sample is associated with the corresponding standard sample and stored in the database.

10. A sample analysis system, characterized in that: include: A computing device, comprising a processor and a memory, wherein the memory stores a computer program, and when the computer program is executed by the processor, the steps of the calibration method according to any one of claims 1 to 9 are implemented; At least one sample analyzer is used to perform calibration tasks according to control instructions of the computing device.

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