Pharmaceutical equipment, pharmaceutical method, and medicament for sanhuang qingjie capsules

Abstract

The present invention relates to the technical field of pharmaceutical equipment, and specifically relates to pharmaceutical equipment, a pharmaceutical method and a medicament for Sanhuang Qingjie capsules, and comprises the pharmaceutical equipment and pharmaceutical raw materials for the pharmaceutical equipment for Sanhuang Qingjie capsules. In the present invention, during the production of Sanhuang Qingjie capsules, when drug powders are sampled in the drying process, drug powders of different specifications can be conveniently extracted, such that the detection of the raw materials is performed more comprehensively, the accuracy of the detection results are improved, and the detection work is also performed more efficiently and conveniently. In addition, the raw materials required for 1000 capsules are as follows: 67 g of Coptidis rhizoma, 100 g of Scutellariae radix, 67 g of Phellodendri chinensis cortex, 133 g of Lonicerae japonica flos, 133 g of Forsythiae fructus, an appropriate amount of 95% ethanol, an appropriate amount of drinking water, and an appropriate amount of purified water.

Description

Pharmaceutical equipment, pharmaceutical method and medicament of Sanhuang Qingjie capsule Technical Field

[0001] The present invention relates to the technical field of pharmaceutical equipment, and in particular to pharmaceutical equipment, a pharmaceutical method and a medicament of Sanhuang Qingjie capsule. Background Art

[0002] Medicines are products that are made of synthetic materials or raw materials to purposefully prevent, treat, and diagnose diseases of the human body. They come in various forms, such as tablets and capsules. The production process of medicines involves many links and equipment. For example, a lot of equipment and machinery are used in the production of Sanhuang Qingjie Capsules.

[0003] Sanhuang Qingjie Capsules are generally hard capsules with brown granules and powder as the contents. They taste bitter and can clear away heat and detoxify. They are used for wind-heat fever, fever, cough and asthma, mouth sores and swollen throat, hot stranguria and dysentery. Technical issues

[0004] During the production of Sanhuang Qingjie Capsules, a lot of raw materials will be decocted, and will also go through steps such as filtration, concentration, mixing and drying. In the process, equipment such as reactors, dryers, and mixers will be used. In the production of Sanhuang Qingjie Capsules, the drug powder in the production process will be sampled and tested to check whether the specifications and quality of the drugs and other data meet the standards. The inventors found in daily use that the existing drug powder sampling device is difficult to accurately control the extracted drug samples when sampling drugs, so that the staff needs to perform screening work before testing, which will lead to a decrease in the work efficiency of the drug production, and to a certain extent reduce the accuracy and reliability of the test results. Technical Solutions

[0005] The purpose of the present invention is to solve the problem in the prior art that the existing drug powder sampling device is difficult to accurately control the extracted drug samples when sampling drugs, so that the staff need to perform screening work before testing, which will lead to a decrease in the work efficiency during drug production and to a certain extent reduce the accuracy and reliability of the test results. A pharmaceutical equipment, pharmaceutical method and medicine for Sanhuang Qingjie Capsules are proposed.

[0006] In order to achieve the above-mentioned objectives, the present invention adopts the following technical solutions: a pharmaceutical equipment, pharmaceutical method and medicine for Sanhuang Qingjie Capsules, including a sampler, a controller fixedly connected to the surface of the sampler, two handles fixedly connected to the arc surface of the sampler, a partition net fixedly connected to the inner wall of the sampler, an auxiliary conveying component provided on the inner wall of the sampler, a plurality of evenly distributed ventilation holes provided on the arc surface of the sampler, an auxiliary positioning component provided on the surface of the sampler, an installation port provided on the surface of the sampler, a filter component provided on the inner wall of the installation port, a pipe network, an inner diameter of the pipe network is adjustable, and the drug passes through the installation port on the surface of the sampler through the filter component, the auxiliary positioning component fixes the inner diameter of the pipe network through the auxiliary conveying component, and a collecting device is provided on the arc surface of the sampler on the side of the partition net close to the installation port.

[0007] The effect achieved by the above components is: when using a sampler to extract the powder of the drug during the drying process, first insert the sampler into the drying equipment, then install the collecting device on the arc surface of the sampler, then operate and debug the controller on the sampler, regulate the equipment on the controller, and then operate the filter component to adjust the inner diameter of the pipe network on the filter component. After the adjustment is completed, operate the auxiliary positioning component to fix the inner diameter of the pipe network, and under the operation of the auxiliary positioning component, the auxiliary conveying component will be operated to generate a negative pressure wind field, so that the drug powder accumulated in the pipe network and the sampler is not easy to be blocked and accumulated, and can enter the collecting device more conveniently. At this time, when producing Sanhuang Qingjie Capsules, when sampling the drug powder in the drying process, drug powder of different specifications can be conveniently extracted, thereby more comprehensively testing the raw materials, improving the accuracy of the test results, and making the testing work more efficient and convenient.

[0008] Preferably, the filter assembly includes a mounting frame, the mounting frame is fixedly connected to the inner wall of the mounting port, the pipe network is fixedly connected to the inner wall of the mounting frame, the inner wall of the pipe network is hollow, a connecting pipe is provided on one side surface of the pipe network, the other end of the connecting pipe is fixedly connected to a needle tube, a syringe is fixedly connected to the circular arc surface of the sampler, evenly distributed scale lines are provided on the circular arc surface of the syringe, and one end of the syringe is fixedly connected to the needle tube.

[0009] The effect achieved by the above components is: when the inner diameter of the pipe network is adjusted, first push the syringe according to the specifications of the sampled medicinal powder and the indication of the scale line, so that the water in the syringe enters the pipe network through the connecting pipe, causing the pipe network to expand and deform under the action of water. At this time, the holes in the pipe network will shrink and change, so that the size of the holes is adapted to the specifications of the medicinal powder particles to be extracted. At this time, when the sampler is in use, it can better extract samples of different specifications and sizes, further improving the use effect and functionality of the sampler, and also improving the work efficiency of the staff and the efficiency of drug production.

[0010] Preferably, the auxiliary positioning component includes a liquid nitrogen tank, an inlet pipe is fixedly connected to the arc surface of the liquid nitrogen pipe, the liquid nitrogen pipe is fixedly connected to the arc surface of the sampler, one end of the liquid nitrogen tank is fixedly connected to a circulation pump, the input end of the circulation pump is fixedly connected to the liquid nitrogen tank, the circulation pump is fixedly connected to the arc surface of the sampler, the output end of the circulation pump is fixedly connected to a delivery pipe, the other end of the delivery pipe is fixedly connected to an input pipe, a copper pipe is provided on the inner wall of the pipe network, the other end of the input pipe is connected to the copper pipe, and the other end of the copper pipe is fixedly connected to the output pipe.

[0011] The effect achieved by the above components is: when the auxiliary positioning component is used to fix the inner diameter of the pipeline network, the circulation pump and the liquid nitrogen tank are started under the action of the controller, and the liquid nitrogen in the liquid nitrogen tank will enter the delivery pipe through the circulation pump, and then enter the input pipe through the delivery pipe, and then enter the copper pipe in the pipeline network. Because the copper pipe has an energy conducting effect, the water in the pipeline network is solidified under the low temperature of liquid nitrogen, and the inner diameter of the pipeline network is adjusted and fixed. At this time, the inner diameter of the pipeline network is better adjusted, and it is not easy to change abnormally, which improves the practicality of the filter component. Then the liquid nitrogen enters the auxiliary delivery component, which operates the auxiliary delivery component and improves the functionality of the auxiliary positioning component.

[0012] Preferably, the auxiliary conveying assembly includes a mounting box, two connecting plates are fixedly connected to the arc surface of the mounting box, the two connecting plates are respectively fixedly connected to the inner wall of the sampler, a connecting shaft is passed through the surface of the mounting box, one end of the connecting shaft is located at the inner wall position of the mounting box and is fixedly connected to an impeller, the other end of the connecting shaft is clamped with a fan blade group, the end of the connecting shaft away from the impeller is threadedly connected to a positioning block, the positioning block is in contact with the fan blade group, an assembly tube is connected to the arc surface of the mounting box, the assembly tube is fixedly connected to the output tube, and the inlet tube is fixedly connected to the arc surface of the mounting box.

[0013] The effect achieved by the above components is: when the auxiliary output component is in operation, the liquid nitrogen will enter the assembly tube on the installation box from the output pipe, and then fall into the installation box through the assembly tube, and hit the blades of the impeller, causing the impeller to rotate, thereby driving the fan blade group at one end of the impeller connecting shaft to rotate, and because of the presence of the vent, negative pressure wind is generated inside the sampler, and because the partition net can only allow wind to pass through, it can also isolate the passage of drug powder, thereby causing the drug powder accumulated under the installation port to move, and finally enter the collection device to improve the use effect of the sampler.

[0014] Preferably, a reinforcement block is rotatably connected to the arc surface of the connecting shaft, and three evenly distributed reinforcement rods are fixedly connected to the surface of the reinforcement block, and the three reinforcement rods are respectively fixed on the arc surface of the sampler.

[0015] The effect achieved by the above components is: through the setting of the reinforcement rod and the reinforcement block, the connecting shaft obtains a certain support effect, and the connecting shaft is not easy to consume too much rotational energy of the impeller due to the gravity of the fan blade group, so that the fan blade group rotates faster under the drive of the impeller, and can generate a larger negative pressure wind field, so as to better move the drug powder accumulated inside the sampler and enter the collection device, further improving the use effect of the auxiliary conveying component.

[0016] Preferably, the collecting device includes a sampling bottle, a socket is provided on the arc surface of the sampler, the sampling bottle is inserted into the inner wall of the socket, two clamps are fixedly connected to the position of the socket on the arc surface of the sampler, and the two clamps are respectively abutted against the arc surface of the sampling bottle, a slide is slidably connected to the position of the socket on the arc surface of the sampler, a groove is provided on the surface of the slide, a slider is slidably connected to the inner wall of the groove, the surface of the slider is fixedly connected to a limiting frame, and the limiting frame is fixedly connected to the arc surface of the sampler.

[0017] The effect achieved by the above components is: when using a collecting device to collect the medicinal powder extracted by the sampler, first slide the slide to expose the socket on the sampler, and make the slider on the limit frame slide on the inner wall of the slide groove of the slide, and then insert the extraction bottle into the socket, and fix it in the limit position under the contact and extrusion of the two card plates. At this time, the powder particles collected inside the sampler will enter the sampling bottle through the socket.

[0018] Preferably, the filter assembly also includes an assembly frame, the assembly frame is fixed on the inner wall of the installation port, the inner wall of the assembly frame is fixedly connected to a filter screen, the inner wall of the sampler is located at the position of the installation port and is fixedly connected to two fixed blocks, the two fixed blocks are fixedly connected to a connecting frame on one side close to each other, the surface of the connecting frame is fixedly connected to a plurality of balloons, one side surface of the connecting frame is connected to the connecting pipe, the inner wall of the connecting frame is provided with a copper tube, the copper tube is fixedly connected to the input pipe, the other side surface of the copper tube is fixedly connected to the output pipe, the surface of the assembly frame is fixedly connected to a stabilizing frame, the surface of the stabilizing frame is fixedly connected to a plurality of evenly distributed stabilizing columns, and a plurality of the stabilizing columns are respectively fixedly connected to the surfaces of a plurality of balloons.

[0019] The effect achieved by the above components is as follows: when the aperture size of the filter is adjusted, water is injected into the hollow connecting frame through a syringe and a connecting tube, and then continues to be injected into several balloons on the connecting frame, so that a specified amount of water is injected into the balloons, causing the balloons to expand and change. Because the balloons are in the holes of the filter, the inner diameter of the holes changes until it changes to the specified specifications. At this time, liquid nitrogen is poured in to solidify the water in the connecting frame and the balloons. At the same time, the stabilizing column on the stabilizing frame will keep the balloons in the hole position of the filter, and it is not easy to deviate. At this time, the sampler can extract the required drug powder particles of different specifications and sizes, thereby conveniently testing the raw materials of the capsules when they are produced, improving the convenience and efficiency of the sampling work.

[0020] Preferably, the filter assembly also includes a combination frame, which is fixedly connected to the installation port on the inner wall of the sampler. The surface of the combination frame is connected to a number of evenly distributed bellows, and the surfaces of the several bellows are respectively fixedly connected with adjustment blocks. The cross-section of the adjustment block is conical, and the inner wall of the combination frame is provided with a copper tube. The surface of the combination frame is connected to the connecting pipe.

[0021] The effect achieved by the above components is: when the aperture size of the filter is adjusted, water is injected into the hollow combination frame through a syringe and then poured into the bellows, so that the bellows is deformed and extended under the injection of water, thereby driving the adjustment block to gradually insert into the holes of the filter, causing the aperture size of the filter to change, and then under the action of the auxiliary positioning component, the water in the bellows is solidified to keep the aperture size of the filter fixed. At this time, when the sampler samples the drug powder, it can more conveniently sample and extract powder particles of different specifications, thereby improving the efficiency of the sampling work.

[0022] Preferably, the surface of the sampler is fixedly connected to two fixed plates at the position of the mounting port, the surfaces of the two fixed plates are respectively fixedly connected to electric telescopic rods, the surfaces of the electric telescopic rods are fixedly connected to positioning frames, the surface of the positioning frames are fixedly connected to a number of evenly distributed positioning columns, the surface of the positioning columns is provided with a positioning groove on the side close to the adjustment block, and the inner wall of the positioning groove abuts against the adjustment block.

[0023] The effect achieved by the above components is: when the adjusting block on the bellows moves to change the aperture size of the filter screen, the positioning groove on the positioning column will be stuck on the adjusting block, and will move stably under the drive of the electric telescopic rod and will not easily separate. At this time, the adjusting block will not easily shake when adjusting the aperture of the filter screen, thereby keeping the aperture stable and not prone to abnormal changes.

[0024] Preferably, a pharmaceutical method of Sanhuang Qingjie Capsule is provided:

[0025] S1. When sampling the powder medicine during the drying process of Sanhuang Qingjie Capsules, first hold the handle on the sampler and insert the sampler on the surface of the dryer, then operate the controller to debug and set the setting parameters on the sampler;

[0026] S2. Then slide the slide and insert the sampling bottle into the socket on the arc surface of the sampler so that the sample is fixed by the two clamping plates;

[0027] S3. Then, push the syringe in the filter assembly to inject a certain amount of water into the pipe network according to the scale line, adjust the inner diameter of the pipe network at the installation port, and start the circulation pump and liquid nitrogen tank at the same time. The liquid nitrogen will be transported into the copper pipe in the pipe network through the pipeline, so that the water will condense into a solid state under the low temperature of the liquid nitrogen, thereby fixing the inner diameter of the pipe network;

[0028] S4. At this time, liquid nitrogen will be transported through the output pipe and the assembly pipe to the installation box, thereby hitting the impeller, causing the impeller to rotate, thereby driving the fan blade group to rotate, generating a negative pressure wind field, and the liquid nitrogen is then output from the inlet pipe and re-enters the liquid nitrogen tank to form a cycle, so that the wind field remains stable. At this time, the drug powder of specific specifications in the dryer will enter the sampler under the action of the wind field, and it is not easy to form accumulation on the pipe network. At the same time, the drug powder accumulated under the installation port inside the sampler will also approach the fan blade under the action of the wind field, and enter the sampling bottle when the powder is separated by the partition net to complete the sampling.

[0029] A raw material, a pharmaceutical raw material for the pharmaceutical equipment of the Sanhuang Qingjie Capsule, the raw materials required for 1000 capsules are as follows: 67g of Coptis chinensis; 100g of Scutellaria baicalensis; 67g of Phellodendron chinense; 133g of Honeysuckle; 133g of Forsythia suspensa; an appropriate amount of 95% ethanol;

[0030] Drinking water in appropriate amounts; purified water in appropriate amounts.

[0031] Specifically, according to the above medicament, forsythia suspensa and honeysuckle are decocted twice with 12 times the amount of water, the first time for 1.5 hours and the second time for 1 hour. Phellodendron chinense is decocted twice with 8 times the amount of water, each time for 2 hours. The decoctions are combined, filtered, and the filtrate is concentrated under reduced pressure (vacuum degree 0.07 MPa, 80°C) to a thick paste with a relative density of 1.30-1.35 (50°C). Coptis chinensis and Scutellaria baicalensis are pulverized into fine powder, added to the thick paste, mixed, dried under reduced pressure (vacuum degree 0.07 MPa, 80°C), pulverized, passed through a 16-mesh sieve, granulated, dried, and encapsulated into 1000 capsules. Beneficial effects

[0032] In summary, the beneficial effects of the present invention are:

[0033] In the production of Sanhuang Qingjie Capsules, when sampling the drug powder during the drying process, drug powder of different specifications can be easily extracted, thereby conducting a more comprehensive test on the raw materials, improving the accuracy of the test results, and making the testing work more efficient and convenient.

[0034] The pore size of the filter component can be better adjusted, and abnormal changes are less likely to occur, which improves the practicality of the filter component. Then the liquid nitrogen enters the auxiliary conveying component, which operates the auxiliary conveying component and improves the functionality of the auxiliary positioning component.

[0035] The negative pressure wind force of the auxiliary conveying component moves the drug powder accumulated below the installation port and on the filter component, and finally enters the collection device, thereby improving the use effect of the sampler. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] FIG1 is a schematic diagram of the three-dimensional structure of the present invention;

[0037] FIG2 is a schematic diagram of a cross-sectional three-dimensional structure of a sampler according to the present invention;

[0038] FIG3 is a schematic diagram of the three-dimensional structure of some components of the present invention;

[0039] FIG4 is a schematic diagram of a cross-sectional three-dimensional structure of a copper tube and a pipe network according to Example 1 of the present invention;

[0040] FIG5 is a schematic diagram of a partial three-dimensional structure of Example 2 of the present invention;

[0041] FIG6 is a schematic diagram of a partial three-dimensional structure of FIG5 of the present invention;

[0042] FIG7 is a schematic cross-sectional perspective view of the copper tube and the connecting frame according to Example 2 of the present invention;

[0043] FIG8 is a schematic diagram of a partial three-dimensional structure of Example 3 of the present invention;

[0044] FIG9 is a schematic diagram of a partial three-dimensional structure of FIG8 of the present invention;

[0045] FIG10 is a schematic cross-sectional perspective view of the copper tube and assembly frame according to Example 3 of the present invention;

[0046] FIG11 is a schematic diagram of the exploded three-dimensional structure of the auxiliary conveying assembly of the present invention;

[0047] FIG12 is a schematic diagram of the three-dimensional structure of the collecting device of the present invention.

[0048] Legend: 1. Sampler; 2. Filter assembly; 21. Mounting frame; 22. Pipe network; 23. Copper tube; 24. Output tube; 25. Input tube; 26. Connecting tube; 27. Needle tube; 28. Syringe; 29. ​​Scale line; 210. Assembly frame; 211. Filter screen; 212. Connecting frame; 213. Fixing block; 214. Balloon; 215. Stabilizing frame; 216. Stabilizing column; 217. Combination frame; 218. Bellows; 219. Adjusting block; 220. Positioning frame; 221. Positioning column; 222. Positioning slot; 223. Fixing plate; 22 4. Electric rope telescopic rod; 3. Auxiliary positioning assembly; 31. Circulation pump; 32. Liquid nitrogen tank; 33. Delivery pipe; 34. Inlet pipe; 4. Auxiliary delivery assembly; 41. Installation box; 42. Connecting plate; 43. Assembly pipe; 44. Impeller; 45. Connecting shaft; 46. Fan blade group; 47. Positioning block; 48. Reinforcement block; 49. Reinforcement rod; 5. Collection device; 51. Socket; 52. Sampling bottle; 53. Card plate; 54. Slide plate; 55. Limiting frame; 56. Slider; 57. Slide; 6. Partition net; 7. Controller; 8. Ventilation port; 9. Installation port. Modes for Carrying Out the Invention

[0049] As shown in Figure 1, the present invention provides a technical solution: a pharmaceutical equipment, pharmaceutical method and medicine for Sanhuang Qingjie Capsules, including a sampler 1, a controller 7 is fixedly connected to the surface of the sampler 1, two handles are fixedly connected to the arc surface of the sampler 1, a partition net 6 is fixedly connected to the inner wall of the sampler 1, an auxiliary conveying component 4 is provided on the inner wall of the sampler 1, a number of evenly distributed ventilation holes 8 are opened on the arc surface of the sampler 1, an auxiliary positioning component 3 is provided on the surface of the sampler 1, a mounting port 9 is opened on the surface of the sampler 1, a filter component 2 is provided on the inner wall of the mounting port 9, the filter component 2 includes a pipe network 22, the inner diameter of the pipe network 22 is adjustable, and the drug passes through the mounting port 9 on the surface of the sampler 1 through the filter component 2, the auxiliary positioning component 3 fixes the inner diameter of the pipe network 22 through the auxiliary conveying component 4, and a collecting device 5 is provided on the arc surface of the sampler 1 on the side of the partition net 6 close to the mounting port 9. Example 1,

[0050] 2, in this embodiment: when the sampler 1 is used to extract the powder of the drug during the drying process, the sampler 1 is first inserted into the drying equipment, and then the collecting device 5 is installed on the arc surface of the sampler 1, and then the controller 7 on the debugger sampler 1 is operated to regulate the equipment on the controller 7, and then the filter component 2 is operated to adjust the inner diameter of the pipe network 22 on the filter component 2. After the adjustment is completed, the auxiliary positioning component 3 is operated to fix the inner diameter of the pipe network 22, and under the operation of the auxiliary positioning component 3, the auxiliary conveying component is operated to generate a negative pressure wind field, so that the drug powder accumulated in the pipe network 22 and the sampler 1 inside is not easily blocked and accumulated, and can enter the collecting device 5 more conveniently. At this time, when the Sanhuang Qingjie Capsule is produced, when sampling the drug powder in the drying process, drug powder of different specifications can be conveniently extracted, thereby more comprehensively testing the raw materials, improving the accuracy of the test results, and making the detection work more efficient and convenient. The filter component 2 includes a mounting frame 21, and the mounting frame 21 is fixedly connected to the inner wall of the mounting port 9, the pipe network 22 is fixedly connected to the inner wall of the mounting frame 21, the inner wall of the pipe network 22 is hollow, one side surface of the pipe network 22 is connected with a connecting pipe 26, the other end of the connecting pipe 26 is fixedly connected with a needle tube 27, the arc surface of the sampler 1 is fixedly connected with a syringe 28, the arc surface of the syringe 28 is provided with evenly distributed scale lines 29, one end of the syringe 28 is fixedly connected to the needle tube 27, when the inner diameter of the pipe network 22 is adjusted, first according to the specifications of the sampled drug powder, and According to the indication of the scale line 29, push the syringe 28 so that the water in the syringe 28 enters the pipe network 22 through the connecting tube 26, causing the pipe network 22 to expand and deform under the action of water. At this time, the holes in the pipe network 22 will shrink and change, so that the size of the holes is adapted to the size of the required drug powder particles to be extracted. At this time, when the sampler 1 is in use, it can better extract samples of different sizes, further improving the use effect and functionality of the sampler 1, and also improving the work efficiency of the staff and the efficiency of drug production.

[0051] 1 , 3 and 4 , in this embodiment: the auxiliary positioning component 3 includes a liquid nitrogen tank 32, an inlet pipe 34 is fixedly connected to the arc surface of the liquid nitrogen pipe, the liquid nitrogen pipe is fixedly connected to the arc surface of the sampler 1, one end of the liquid nitrogen tank 32 is fixedly connected to a circulation pump 31, the input end of the circulation pump 31 is fixedly connected to the liquid nitrogen tank 32, the circulation pump 31 is fixedly connected to the arc surface of the sampler 1, the output end of the circulation pump 31 is fixedly connected to a delivery pipe 33, the other end of the delivery pipe 33 is fixedly connected to an input pipe 25, the inner wall of the pipe network 22 is provided with a copper pipe 23, the other end of the input pipe 25 is connected to the copper pipe 23, and the other end of the copper pipe 23 is fixedly connected to the output pipe 24. When the auxiliary positioning component is used When component 3 fixes the inner diameter of the pipe network 22, the circulation pump 31 and the liquid nitrogen tank 32 are started under the action of the controller 7. The liquid nitrogen in the liquid nitrogen tank 32 will enter the delivery pipe 33 through the circulation pump 31, and then enter the input pipe 25 through the delivery pipe 33, and then enter the copper tube 23 in the pipe network 22. Because the copper tube 23 has an energy conducting effect, the water in the pipe network 22 is solidified under the low temperature of the liquid nitrogen, and the inner diameter of the pipe network 22 is adjusted and fixed. At this time, the inner diameter of the pipe network 22 is better adjusted, and it is not easy to change abnormally, thereby improving the practicality of the filter component 2. Then the liquid nitrogen enters the auxiliary delivery component 4, operates the auxiliary delivery component 4, and improves the functionality of the auxiliary positioning component 3.

[0052] 1, 3 and 11, in this embodiment: the auxiliary conveying assembly 4 includes a mounting box 41, and two connecting plates 42 are fixedly connected to the arc surface of the mounting box 41. The two connecting plates 42 are respectively fixedly connected to the inner wall of the sampler 1. A connecting shaft 45 is passed through the surface of the mounting box 41. One end of the connecting shaft 45 is located at the inner wall position of the mounting box 41 and is fixedly connected to an impeller 44. The other end of the connecting shaft 45 is clamped with a fan blade group 46. The end of the connecting shaft 45 away from the impeller 44 is threadedly connected to a positioning Block 47, the positioning block 47 is in contact with the fan blade group 46, and the arc surface of the mounting box 41 is connected with an assembly pipe 43, which is fixedly connected to the output pipe 24, and the inlet pipe 34 is fixedly connected to the arc surface of the mounting box 41. When the auxiliary output component is running, liquid nitrogen will enter the assembly pipe 43 on the mounting box 41 from the output pipe 24, and then fall into the mounting box 41 through the assembly pipe 43, and hit the blades of the impeller 44, causing the impeller 44 to rotate, thereby driving the impeller 44 to connect the shaft 45 The fan blade group 46 at one end rotates, and because of the existence of the vent 8, a negative pressure wind is generated inside the sampler 1. Because the partition net 6 can only allow wind to pass through, it can also block the passage of drug powder, thereby causing the drug powder accumulated below the installation port 9 to move and finally enter the collecting device 5 to improve the use effect of the sampler 1. A reinforcement block 48 is rotatably connected to the arc surface of the connecting shaft 45, and three evenly distributed reinforcement rods 49 are fixedly connected to the surface of the reinforcement block 48. The three reinforcement rods 49 are respectively fixed on the arc surface of the sampler 1. Through the arrangement of the reinforcement rods 49 and the reinforcement block 48, the connecting shaft 45 obtains a certain support effect. The connecting shaft 45 is not easy to consume too much rotational energy of the impeller 44 due to the gravity of the fan blade group 46, so that the fan blade group 46 rotates faster under the drive of the impeller 44, which can generate a larger negative pressure wind field, better move the drug powder accumulated inside the sampler 1, and enter the collecting device 5, further improving the use effect of the auxiliary conveying component 4.

[0053] 1, 2 and 12, in this embodiment: the collecting device 5 includes a sampling bottle 52, a socket 51 is provided on the arc of the sampler 1, the sampling bottle 52 is plugged into the inner wall of the socket 51, and two clamping plates 53 are fixedly connected to the position of the socket 51 on the arc surface of the sampler 1, and the two clamping plates 53 are respectively in contact with the arc surface of the sampling bottle 52, and a slide plate 54 is slidably connected to the position of the socket 51 on the arc surface of the sampler 1, and a slide groove 57 is provided on the surface of the slide groove 57, and a slider 56 is slidably connected to the inner wall of the slider groove 57. The surface of block 56 is fixedly connected to the limiting frame 55, and the limiting frame 55 is fixedly connected to the arc surface of the sampler 1. When the collecting device 5 is used to collect the medicinal powder extracted by the sampler 1, first slide the slide 54 to expose the socket 51 on the sampler 1, and make the slider 56 on the limiting frame 55 slide on the inner wall of the slide groove 57 of the slide 54, and then insert the extraction bottle into the socket 51, and fix it under the contact and extrusion of the two clamping plates 53. At this time, the powder particles collected inside the sampler 1 will enter the sampling bottle 52 through the socket 51. Example 2,

[0054] 1 and 5-7, in this embodiment: the filter assembly 2 also includes a combination frame 217, the combination frame 217 is fixedly connected to the position of the mounting port 9 at the inner wall position of the sampler 1, the surface of the combination frame 217 is connected with a number of evenly distributed bellows 218, the surfaces of the several bellows 218 are respectively fixedly connected with adjustment blocks 219, the cross-section of the adjustment block 219 is conical, the inner wall of the combination frame 217 is provided with a copper tube 23, the surface of the combination frame 217 is connected to the connecting pipe 26, when the aperture size of the filter screen 211 is adjusted, the syringe 2 is used to adjust the filter screen 211. 8 Water is injected into the hollow combination frame 217 and into the bellows 218, so that the bellows 218 is deformed and extended under the injection of water, thereby driving the adjustment block 219 to gradually insert into the holes of the filter 211, so that the aperture size of the filter 211 changes, and then under the action of the auxiliary positioning component 3, the water in the bellows 218 is solidified to keep the aperture size of the filter 211 fixed. At this time, when the sampler 1 samples the drug powder, it can more conveniently sample and extract powder particles of different specifications, thereby improving the efficiency of the sampling work. Example 3,

[0055] 1 and 8-10, in this embodiment: the filter assembly 2 also includes a combination frame 217, the combination frame 217 is fixedly connected to the position of the mounting port 9 at the inner wall position of the sampler 1, the surface of the combination frame 217 is connected with a number of evenly distributed bellows 218, the surfaces of the several bellows 218 are respectively fixedly connected with adjustment blocks 219, the cross section of the adjustment block 219 is tapered, the inner wall of the combination frame 217 is provided with a copper tube 23, the surface of the combination frame 217 is connected to the connecting pipe 26, when the aperture size of the filter screen 211 is adjusted When the water is injected into the hollow assembly frame 217 through the syringe 28, and then poured into the bellows 218, the bellows 218 is deformed and extended under the injection of water, thereby driving the adjustment block 219 to gradually insert into the hole of the filter 211, so that the pore size of the filter 211 changes. Then, under the action of the auxiliary positioning component 3, the water in the bellows 218 is solidified, so that the pore size of the filter 211 remains fixed. At this time, when the sampler 1 passes through the sample of the drug powder, it can The sampling and extraction of powder particles of different specifications can be carried out more conveniently, thereby improving the working efficiency of the sampling work. The surface of the sampler 1 is fixedly connected to the two fixing plates 223 at the position of the mounting port 9. The surfaces of the two fixing plates 223 are respectively fixedly connected with the electric telescopic rods 224. The surface of the electric telescopic rods 224 is fixedly connected with the positioning frame 220. The surface of the positioning frame 220 is fixedly connected with a number of evenly distributed positioning columns 221. The surface of the positioning column 221 is provided with a positioning groove 222 on the side close to the adjusting block 219. The inner wall of the positioning groove 222 abuts against the adjusting block 219. When the adjusting block 219 on the bellows 218 moves and the aperture size of the filter screen 211 changes, the positioning groove 222 on the positioning column 221 will be stuck on the adjusting block 219, and will move stably under the drive of the electric telescopic rod 224, and will not easily separate. At this time, when the adjusting block 219 adjusts the aperture of the filter screen 211, it is not easy to shake, thereby keeping the aperture stable and not prone to abnormal changes.

[0056] In addition, the present invention also provides a raw material, which is the pharmaceutical raw material of the pharmaceutical equipment of the Sanhuang Qingjie Capsules. The raw materials required for 1,000 capsules are as follows: 67g of Coptis chinensis; 100g of Scutellaria baicalensis; 67g of Phellodendron chinense; 133g of Honeysuckle; 133g of Forsythia suspensa; an appropriate amount of 95% ethanol; an appropriate amount of drinking water; and an appropriate amount of purified water.

[0057] Specifically, according to the above medicament, forsythia suspensa and honeysuckle are decocted twice with 12 times the amount of water, the first time for 1.5 hours and the second time for 1 hour. Phellodendron chinense is decocted twice with 8 times the amount of water, each time for 2 hours. The decoctions are combined, filtered, and the filtrate is concentrated under reduced pressure (vacuum degree 0.07 MPa, 80°C) to a thick paste with a relative density of 1.30-1.35 (50°C). Coptis chinensis and Scutellaria baicalensis are pulverized into fine powder, added to the thick paste, mixed, dried under reduced pressure (vacuum degree 0.07 MPa, 80°C), pulverized, passed through a 16-mesh sieve, granulated, dried, and encapsulated into 1000 capsules.

[0058] Working principle: When sampling the powder medicine during the drying period in the pharmaceutical process of Sanhuang Qingjie Capsules, first hold the handle on the sampler 1 and insert the sampler 1 on the surface of the dryer. Then operate the controller 7 to debug and set the setting parameters on the sampler 1. Then slide the slide 54 and insert the sampling bottle 52 into the socket 51 on the arc surface of the sampler 1 so that the sample is fixed by the two clamping plates 53. Then push the syringe 28 in the filter assembly 2 and inject a certain amount of water into the pipe network 22 according to the scale line 29. Adjust the inner diameter of the pipe network 22 at the installation port 9 and start the circulation pump 31 and the liquid nitrogen tank 32 at the same time. The liquid nitrogen will be transported into the copper pipe 23 in the pipe network 22 through the pipeline, so that the water is in the liquid nitrogen. Under the action of low temperature, it condenses into a solid state and fixes the inner diameter of the pipe network 22. At this time, the liquid nitrogen will be transported to the installation box 41 through the output pipe 24 and the assembly pipe 43, thereby hitting the impeller 44, causing the impeller 44 to rotate, thereby driving the fan blade group 46 to rotate, generating a negative pressure wind field, and the liquid nitrogen is then output from the inlet pipe 34 and re-enters the liquid nitrogen tank 32 to form a cycle, so that the wind field remains stable. At this time, the drug powder of specific specifications in the dryer will enter the sampler 1 under the action of the wind field, and it is not easy to form accumulation on the pipe network 22. At the same time, the drug powder accumulated below the installation port 9 inside the sampler 1 will also approach the fan blades under the action of the wind field, and enter the sampling bottle 52 when the powder is isolated by the partition net 6 to complete the sampling.

Claims

1. A pharmaceutical device for Sanhuang Qingjie capsules, including a sampler (1), characterized in that: A controller (7) is fixedly connected to the surface of the sampler (1). Two handles are fixedly connected to the arc surface of the sampler (1). A partition net (6) is fixedly connected to the inner wall of the sampler (1). An auxiliary conveying component (4) is arranged on the inner wall of the sampler (1). A number of uniformly distributed ventilation openings (8) are formed in the arc surface of the sampler (1). An auxiliary positioning component (3) is arranged on the surface of the sampler (1). An installation opening (9) is formed in the surface of the sampler (1). A filtering component (2) is arranged on the inner wall of the installation opening (9). The filtering component (2) includes a pipe network (22). The inner diameter of the pipe network (22) is adjustable, and the drug passes through the filtering component (2) and passes through the installation opening (9) on the surface of the sampler (1). The auxiliary positioning component (3) fixes the inner diameter of the pipe network (22) through the auxiliary conveying component (4). A collecting device (5) is arranged on the arc surface of the sampler (1) on the side of the partition net (6) close to the installation opening (9).

2. The pharmaceutical equipment for the Sanhuang Qingjie Capsule according to claim 1, characterized in that: The filtering component (2) includes an installation frame (21). The installation frame (21) is fixedly connected to the inner wall of the installation opening (9). The pipe network (22) is fixedly connected to the inner wall of the installation frame (21). The inner wall of the pipe network (22) is hollow. A connecting pipe (26) is communicated and arranged on one side surface of the pipe network (22). The other end of the connecting pipe (26) is fixedly connected to a syringe needle (27). A syringe (28) is fixedly connected to the arc surface of the sampler (1). Uniformly distributed scale lines (29) are formed in the arc surface of the syringe (28). One end of the syringe (28) is fixedly connected to the syringe needle (27).

3. The pharmaceutical equipment for a Sanhuang Qingjie capsule according to claim 2, characterized in that: The auxiliary positioning component (3) includes a liquid nitrogen tank (32). An inlet pipe (34) is fixedly connected to the arc surface of the liquid nitrogen pipe. The liquid nitrogen pipe is fixedly connected to the arc surface of the sampler (1). One end of the liquid nitrogen tank (32) is fixedly connected to a circulation pump (31). The input end of the circulation pump (31) is fixedly connected to the liquid nitrogen tank (32). The circulation pump (31) is fixedly connected to the arc surface of the sampler (1). The output end of the circulation pump (31) is fixedly connected to a delivery pipe (33). The other end of the delivery pipe (33) is fixedly connected to an input pipe (25). A copper pipe (23) is arranged on the inner wall of the pipe network (22). The other end of the input pipe (25) is communicated and arranged with the copper pipe (23). The other end of the copper pipe (23) is fixedly connected to an output pipe (24).

4. The pharmaceutical equipment for Sihuang Qingjie Capsules according to claim 3, characterized in that: The auxiliary conveying component (4) includes an installation box (41). Two connecting plates (42) are fixedly connected to the arc surface of the installation box (41). The two connecting plates (42) are respectively fixedly connected to the inner wall of the sampler (1). A connecting shaft (45) penetrates through the surface of the installation box (41). One end of the connecting shaft (45) is fixedly connected with an impeller (44) at the position of the inner wall of the installation box (41). A fan blade group (46) is clamped at the other end of the connecting shaft (45). A positioning block (47) is threadedly connected to the end of the connecting shaft (45) away from the impeller (44). The positioning block (47) abuts against the fan blade group (46). An assembly pipe (43) is communicated with the arc surface of the installation box (41). The assembly pipe (43) is fixedly connected with the output pipe (24). The inlet pipe (34) is fixedly connected to the arc surface of the installation box (41). A reinforcing block (48) is rotatably connected to the arc surface of the connecting shaft (45). Three uniformly distributed reinforcing rods (49) are fixedly connected to the surface of the reinforcing block (48). The three reinforcing rods (49) are respectively fixed on the arc surface of the sampler (1).

5. The pharmaceutical equipment for Sanhuang Qingjie capsules according to claim 4, characterized in that: The collection device (5) includes a sampling bottle (52). An insertion opening (51) is formed in the arc surface of the sampler (1). The sampling bottle (52) is inserted into the inner wall of the insertion opening (51). Two clamping plates (53) are fixedly connected to the arc surface of the sampler (1) at the position of the insertion opening (51). The two clamping plates (53) respectively abut against the arc surface of the sampling bottle (52). A sliding plate (54) is slidably connected to the arc surface of the sampler (1) at the position of the insertion opening (51). A sliding groove (57) is formed in the surface of the sliding plate (54). A sliding block (56) is slidably connected to the inner wall of the sliding groove (57). A limiting frame (55) is fixedly connected to the surface of the sliding block (56). The limiting frame (55) is fixedly connected to the arc surface of the sampler (1).

6. The pharmaceutical equipment for the Sanhuang Qingjie Capsule according to claim 5, characterized in that: The filtering component (2) further includes an assembly frame. The assembly frame (210) is fixed to the inner wall of the installation opening (9). A filter screen (211) is fixedly connected to the inner wall of the assembly frame (210). Two fixing blocks (213) are fixedly connected to the inner wall of the sampler (1) at the position of the installation opening (9). A connecting frame (212) is fixedly connected to the side of the two fixing blocks (213) close to each other. A plurality of balloons (214) are fixedly connected to the surface of the connecting frame (212). One side surface of the connecting frame (212) is communicated with the connecting pipe (26). A copper pipe (23) is arranged in the inner wall of the connecting frame (212). The copper pipe (23) is fixedly connected with the input pipe (25). The other side surface of the copper pipe (23) is fixedly connected with the output pipe (24). A stabilizing frame (215) is fixedly connected to the surface of the assembly frame (210). A plurality of uniformly distributed stabilizing columns (216) are fixedly connected to the surface of the stabilizing frame (215). The plurality of stabilizing columns (216) are respectively fixedly connected to the surfaces of the plurality of balloons (214).

7. The pharmaceutical equipment for Sihuang Qingjie capsules according to claim 6, characterized in that: The filtering component (2) further includes a combined rack (217), the combined rack (217) is fixedly connected to the position of the mounting port (9) on the inner wall of the sampler (1), and a number of uniformly distributed corrugated pipes (218) are communicatively arranged on the surface of the combined rack (217). Adjusting blocks (219) are fixedly connected to the surfaces of the number of corrugated pipes (218) respectively. The cross-section of the adjusting block (219) is conical. A copper pipe (23) is arranged on the inner wall of the combined rack (217), and the surface of the combined rack (217) is communicatively connected to a connecting pipe (26).

8. The pharmaceutical equipment for Sanhuang Qingjie capsules according to claim 7, characterized in that: Two fixing plates (223) are fixedly connected to the surface of the sampler (1) at the position of the mounting port (9). Electric telescopic rods (224) are fixedly connected to the surfaces of the two fixing plates (223) respectively. A positioning rack (220) is fixedly connected to the surface of the electric telescopic rod (224). A number of uniformly distributed positioning columns (221) are fixedly connected to the surface of the positioning rack (220). A positioning groove (222) is formed on one side of the surface of the positioning column (221) close to the adjusting block (219), and the inner wall of the positioning groove (222) abuts against the adjusting block (219).

9. A method, characterized in that: The pharmaceutical method of the pharmaceutical equipment for Sanhuang Qingjie capsules according to claims 1-8 further includes the following steps: S1. When sampling during the drying of the powder medicine in the process of manufacturing Sanhuang Qingjie capsules, first hold the handle on the sampler (1), insert the sampler (1) on the surface of the dryer, and then operate the controller (7) to debug and set the set parameters on the sampler (1). S2. Then slide the slide plate (54), insert the sampling bottle (52) on the socket (51) on the arc surface of the sampler (1), so that the sampled product is limited and fixed by the two clamping plates (53). S3. Then push the syringe (28) in the filtering component (2), inject a quantitative amount of water into the pipe network (22) according to the scale line (29) to adjust the inner diameter of the pipe network (22) at the mounting port (9). At the same time, start the circulation pump (31) and the liquid nitrogen tank (32). The liquid nitrogen will be transported through the pipeline into the copper pipe (23) in the pipe network (22), so that the water condenses into a solid state under the low temperature action of the liquid nitrogen to fix the inner diameter of the pipe network (22). S4. At this time, the liquid nitrogen will be transported through the output pipe (24) and the assembly pipe (43) into the installation box (41), thereby hitting the impeller (44) to make the impeller (44) rotate, thereby driving the fan blade group (46) to rotate, generating a negative pressure wind field. The liquid nitrogen then outputs from the inlet pipe (34) and re-enters the liquid nitrogen tank (32) to form a cycle to keep the wind field stable. At this time, the drug powder of a specific specification in the dryer will enter the sampler (1) under the action of the wind field, and it is not easy to form a pile on the pipe network (22). At the same time, the drug powder accumulated below the mounting port (9) inside the sampler (1) will also move closer to the fan blades under the action of the wind field. In the case of being blocked by the partition net (6) from the powder, it enters the sampling bottle (52) to complete the sampling.

10. A medicament for a pharmaceutical device of the Sanhuang Qingjie Capsule according to any one of claims 1-8, characterized in that: 1000 doses of the medicament include 67 g of Coptis chinensis, 100 g of Scutellaria baicalensis, 67 g of Phellodendron amurense, 133 g of Lonicera japonica, 133 g of Forsythia suspense, appropriate amount of 95% ethanol, appropriate amount of drinking water and appropriate amount of purified water.

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