Ultrasonic transducer-based penetration enhancing system and method

Abstract

The present application provides an ultrasonic transducer-based penetration enhancing system and method and belongs to the technical field of ultrasonic introduction. The system comprises: a penetration enhancing housing, a wearing apparatus, at least one air-coupled ultrasonic transducer, and a control system, wherein the wearing apparatus is arranged outside the penetration enhancing housing, each air-coupled ultrasonic transducer is arranged in the penetration enhancing housing and used for emitting ultrasonic waves to a target area, each air-coupled ultrasonic transducer is in a sheet shape, the control system is electrically connected to the penetration enhancing housing and used for sending a control instruction to each air-coupled ultrasonic transducer, and the control instruction is used for instructing each air-coupled ultrasonic transducer to emit ultrasonic waves. The ultrasonic transducer-based penetration enhancing system of the present application improves the safety and penetration effect of ultrasonic-mediated transdermal penetration of drugs.

Description

Ultrasonic transducer-based penetration enhancement system and method

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS

[0002] This application claims priority to Chinese patent application No. 202311844759.3, filed on December 28, 2023, entitled “Permeation enhancement system and method based on ultrasonic transducer”, which is incorporated herein by reference in its entirety. Technical Field

[0003] The present application relates to the field of ultrasonic transduction technology, and in particular to an ultrasonic transducer-based penetration enhancement system and method. Background Art

[0004] Ultrasound has the effect of promoting the transdermal penetration of drugs. In biological tissues, it improves the permeability of skin cells, opens the gaps between skin cells, dilates skin blood vessels, accelerates blood circulation, promotes cell metabolism, etc. by utilizing multiple biological effects such as cavitation effect, sonoporous effect, mechanical effect, and thermal effect, thereby promoting the transdermal absorption of drugs.

[0005] In the prior art, ultrasound introduction equipment is used to promote drug penetration and transdermal absorption.

[0006] Existing ultrasonic introduction equipment is large in size and lacks portability. The ultrasonic transducer needs to be immersed in water or other acoustic coupling media for use, and needs to be tightly fitted for use, resulting in poor penetration-enhancing effect of ultrasonic penetration and low safety. Summary of the Invention

[0007] In response to the problems existing in the prior art, the present application provides a penetration enhancement system and method based on an ultrasonic transducer.

[0008] The present application provides an ultrasonic transducer-based penetration-enhancing system, comprising: a penetration-enhancing housing, a wearing device, at least one air-coupled ultrasonic transducer, and a control system, wherein:

[0009] The wearing device is arranged outside the penetration-promoting shell;

[0010] Each of the air-coupled ultrasonic transducers is disposed in the penetration-promoting housing and is used to transmit ultrasonic waves to the target area; each of the air-coupled ultrasonic transducers is in the form of a sheet;

[0011] The control system is electrically connected to the penetration-promoting shell and is used to send control instructions to each of the air-coupled ultrasonic transducers; the control instructions are used to instruct each of the air-coupled ultrasonic transducers to emit ultrasonic waves.

[0012] According to the ultrasonic transducer-based penetration enhancement system provided in the present application, the ultrasonic transducer-based penetration enhancement system also includes at least one LED lamp bead.

[0013] According to the ultrasonic transducer-based penetration enhancement system provided in the present application, the ultrasonic transducer-based penetration enhancement system further includes at least one heating device.

[0014] According to the ultrasonic transducer-based penetration enhancement system provided in the present application, each of the LED lamp beads and each of the heating devices are evenly arranged around each of the air-coupled ultrasonic transducers.

[0015] According to the ultrasonic transducer-based penetration-enhancing system provided in the present application, the penetration-enhancing shell is of an arch bridge type or a fitted type.

[0016] According to the ultrasonic transducer-based penetration enhancement system provided in the present application, the wearing device is a fixed structure that fits the physiological skin.

[0017] According to the ultrasonic transducer-based permeation enhancement system provided in the present application, the control system is also used to adjust the ultrasonic energy and operating frequency of each of the air-coupled ultrasonic transducers.

[0018] The present application also provides an ultrasonic transducer-based penetration enhancement method, which is applied to any of the above-mentioned ultrasonic transducer-based penetration enhancement systems, comprising:

[0019] receiving penetration-enhancing instructions;

[0020] Based on the penetration-enhancing instruction, a control instruction is sent to each of the air-coupled ultrasonic transducers; the control instruction is used to instruct each of the air-coupled ultrasonic transducers to emit ultrasonic waves.

[0021] The present application also provides an electronic device, comprising a memory, a processor, and a computer program stored in the memory and executable on the processor, wherein when the processor executes the program, the ultrasonic transducer-based penetration enhancement method as described above is implemented.

[0022] The present application also provides a non-transitory computer-readable storage medium having a computer program stored thereon. When the computer program is executed by a processor, the ultrasonic transducer-based penetration enhancement method as described above is implemented.

[0023] The present application also provides a computer program product, comprising a computer program, which, when executed by a processor, implements any of the above-described methods for enhancing penetration based on an ultrasonic transducer.

[0024] The present application provides a penetration-enhancing system based on an ultrasonic transducer, comprising: a penetration-enhancing shell, a wearing device, at least one air-coupled ultrasonic transducer and a control system, wherein the wearing device is arranged outside the penetration-enhancing shell, and each of the air-coupled ultrasonic transducers is arranged inside the penetration-enhancing shell to transmit ultrasonic waves to the target area; each air-coupled ultrasonic transducer is sheet-shaped; and the control system is electrically connected to the penetration-enhancing shell and is used to send a control instruction to each air-coupled ultrasonic transducer to instruct each air-coupled ultrasonic transducer to transmit ultrasonic waves. The penetration-enhancing system based on an ultrasonic transducer of the present application does not need to be in direct contact with the site of action, nor does it need to ensure close contact with the target site. Ultrasonic waves can be applied to the surface or deep part of human skin, thereby increasing the absorption rate of skin care products or drugs and improving the efficacy of skin care products or drugs. By setting up an air-coupled ultrasonic transducer, the risks of poor penetration effect and skin damage caused by the loose fit of existing ultrasonic penetration-enhancing products are avoided, thereby improving the safety and penetration effect of ultrasound-enhanced drug percutaneous penetration. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] In order to more clearly illustrate the technical solutions in the present application or the prior art, a brief introduction will be given below to the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without any creative work.

[0026] FIG1 is a schematic diagram of a structure of an ultrasonic transducer-based penetration enhancement system provided by the present application;

[0027] FIG2 is a second structural schematic diagram of an ultrasonic transducer-based penetration enhancement system provided by the present application;

[0028] FIG3 is a third structural schematic diagram of the penetration-enhancing system based on ultrasonic transducers provided in the present application;

[0029] FIG4 is a schematic diagram of a flow chart of an ultrasonic transducer-based penetration enhancement method provided by the present application;

[0030] FIG5 is a schematic structural diagram of the electronic device provided in this application. DETAILED DESCRIPTION

[0031] To make the objectives, technical solutions, and advantages of this application more clear, the technical solutions of this application will be clearly and completely described below in conjunction with the accompanying drawings. Obviously, the embodiments described are only part of the embodiments of this application, not all of them. Based on the embodiments of this application, all other embodiments obtained by ordinary technicians in this field without making any creative efforts are within the scope of protection of this application.

[0032] To facilitate understanding of the ultrasonic transducer-based penetration enhancement system and method according to the embodiments of the present application, the following background technology is introduced:

[0033] Ultrasound promotes transdermal drug penetration. In biological tissues, it utilizes various biological effects, including cavitation, sonoporation, mechanical effects, and thermal effects, to increase the permeability of skin cells, open the intercellular spaces between them, dilate skin blood vessels, accelerate blood circulation, and promote cellular metabolism, thereby enhancing transdermal drug absorption. While there are currently some products on the market that promote the transdermal absorption of skincare products and pharmaceutical agents, most of them are small, handheld ultrasound delivery devices that require continuous reciprocating movement across the face to achieve full-face penetration. Alternatively, some larger ultrasound delivery devices are generally bulky, heavy, and lack portability.

[0034] Current ultrasonic permeation devices still require the ultrasonic transducer to be immersed in water or other ultrasonic coupling media for use, and it needs to fit tightly with the facial drug mask to ensure that the ultrasonic waves enter the human skin and achieve the effect of promoting the percutaneous penetration of drugs or skin care products. If the fit is not tight, there is a risk of not being able to achieve the effect of promoting drug penetration, and there is also a risk of causing damage to the human skin. In addition, if the ultrasonic coupling medium leaks out during use, it will directly contact the human skin, posing a risk of damaging the skin and a risk of leakage, which reduces the safety of the ultrasonic permeation device.

[0035] Furthermore, when using current ultrasound infusion devices, a skincare product or serum is typically applied to the infusion site first. Ultrasound then enhances infusion. Ultrasound opens the skin's stratum corneum through various biological effects, including mechanical, cavitation, sonoporation, and thermal effects, thereby promoting absorption of the drug or skincare product. However, opening the stratum corneum takes time, requiring the skincare product to remain on the skin surface for a long time to ensure efficient absorption. Furthermore, moisture in skincare products typically evaporates quickly, and if the skin surface dries after evaporation, the infusion effect is significantly affected. Consequently, this restricts the product's form, evaporation rate, and duration of application, limiting its applicability. Furthermore, the product must be reapplied frequently, leading to rapid product depletion and considerable cumbersomeness. Furthermore, the opened stratum corneum takes over two hours to recover, during which time moisture can evaporate from the skin. Consequently, long-term use of ultrasound infusion devices can increase transepidermal water loss and skin barrier permeability, leading to dry skin and increased allergies.

[0036] The current solution to this problem is to first apply a layer of skin care product to the face after the drug or skin care product is introduced, and then apply a layer of skin care product to the introduction site to repair the stratum corneum barrier. However, this method uses a large amount of skin care product or drug reagent, resulting in waste of skin care product and increasing the cost of introduction and penetration enhancement. To solve the above problem, the embodiments of the present application provide a penetration enhancement system and method based on an ultrasonic transducer.

[0037] The following describes the ultrasonic transducer-based penetration enhancement system and method of the present application in conjunction with Figures 1 to 4.

[0038] FIG1 is one of the structural schematic diagrams of the ultrasonic transducer-based penetration-enhancing system provided by the present application. As shown in FIG1 , the ultrasonic transducer-based penetration-enhancing system of an embodiment of the present application includes a penetration-enhancing housing 10, a wearing device 11, at least one air-coupled ultrasonic transducer 20, and a control system 30, wherein:

[0039] The wearing device is arranged outside the penetration-promoting shell;

[0040] Specifically, in a specific implementation, the shape of the penetration-promoting shell in the penetration-promoting system based on an ultrasonic transducer is not fixed, and can be designed accordingly according to the shape of the part that actually needs to be promoted. The penetration-promoting system based on an ultrasonic transducer shown in FIG1 is used for facial penetration. Therefore, the penetration-promoting shell is presented in the form of a mask. The wearing device is in the form of an ear hook, which is arranged on the outside of the penetration-promoting shell, and there are two of them. In a specific implementation, if the part to be promoted is not the face, the shape of the corresponding penetration-promoting shell may also change. For example, if the target part of the penetration is a flat part, the shape of the penetration-promoting shell may be an arch bridge type. In this case, the shape of the wearing device corresponding to the penetration-promoting shell will also change.

[0041] Furthermore, the material of the wearing device can be a fixing device that fits physiological skin, which can help improve the comfort of the skin in the target area that contacts the wearing device.

[0042] Each of the air-coupled ultrasonic transducers is disposed in the penetration-promoting housing and is used to transmit ultrasonic waves to the target area; each of the air-coupled ultrasonic transducers is in the form of a sheet;

[0043] Specifically, a plurality of air-coupled ultrasonic transducers are provided on the inner surface of the penetration-enhancing housing. Taking the penetration-enhancing housing shown in FIG1 as an example, when the target area for penetration enhancement is the face, that is, when the penetration-enhancing housing is in the form of a mask, the plurality of air-coupled ultrasonic transducers are fixedly attached to the inner surface of the penetration-enhancing housing.

[0044] For example, air-coupled ultrasonic transducers can be arranged at a certain interval on the forehead, cheeks on both sides, chin, etc., and the interval distance can be set to 2-10 mm. Furthermore, the air-coupled ultrasonic transducer is in the form of a sheet, specifically a disc-shaped transducer arranged on the inner surface of the penetration-promoting shell. It should be noted that when the form of the penetration-promoting shell changes, for example, the target part of the penetration-promoting shell is a flat part, the form of the penetration-promoting shell can be an arch bridge type. In this case, the air-coupled ultrasonic transducer arranged on the inner surface of the penetration-promoting shell can be a cylindrical air-coupled ultrasonic transducer with a square bottom surface, and the layout diameter or side length of the disc-shaped air-coupled ultrasonic transducer or the cylindrical ultrasonic transducer with a square bottom surface can be 1-2 cm.

[0045] It should be noted that when the target area for penetration promotion is the face, that is, when the penetration promotion shell is in the form of a mask, in order to ensure that all key areas of the face can receive effective ultrasonic irradiation, 3-10 air-coupled ultrasonic transducers can be arranged on the forehead, 3-10 air-coupled ultrasonic transducers can be arranged on each side of the cheek, and 1-5 air-coupled ultrasonic transducers can be arranged on the chin.

[0046] The control system is electrically connected to the penetration-promoting shell and is used to send control instructions to each of the air-coupled ultrasonic transducers; the control instructions are used to instruct each of the air-coupled ultrasonic transducers to emit ultrasonic waves.

[0047] Specifically, the control system is electrically connected to the penetration-promoting shell, and is used to send control instructions to multiple air-coupled ultrasonic transducers provided on the inner surface of the penetration-promoting shell after receiving the penetration-promoting instruction issued by the user. The control instruction can be used to instruct each air-coupled ultrasonic transducer to transmit ultrasonic waves to the target area. In a specific implementation, the penetration-promoting instruction issued by the user can be selected and issued through the front-end display screen, and can specifically indicate the penetration-promoting type, that is, corresponding to different functions, such as whitening, introduction, cleaning, etc. Different penetration-promoting instructions correspond to different penetration-promoting parameters. Furthermore, the penetration-promoting parameters and working modes are synchronously displayed on the front-end display screen, which are not specifically limited here.

[0048] Specifically, while instructing each air-coupled ultrasonic transducer to emit ultrasonic waves, the control instructions can also control the ultrasonic energy intensity, emission frequency, and emission time of the ultrasonic waves emitted by each air-coupled ultrasonic transducer. For example, the control system drives the air-coupled ultrasonic transducer to emit ultrasonic waves to the target site and continuously act for a period of time. Specifically, the ultrasonic waves can be continuously emitted at the target site for 1-50 minutes, preferably 5-30 minutes. The ultrasonic energy intensity is about 0.1-2W / cm2. In order to achieve a better ultrasonic penetration effect, the frequency of the air-coupled ultrasonic transducer 20 can be selected between 20kHz and 5MHz. The mechanical effect, sonoporous effect, cavitation effect, etc. of ultrasonic waves in biological tissues are used to destroy cell membranes, form drug molecule channels, and promote the absorption of chemical reagents or drugs.

[0049] The present application provides a penetration-enhancing system based on an ultrasonic transducer, comprising: a penetration-enhancing shell, a wearing device, at least one air-coupled ultrasonic transducer and a control system, wherein the wearing device is arranged outside the penetration-enhancing shell, and each of the air-coupled ultrasonic transducers is arranged inside the penetration-enhancing shell to transmit ultrasonic waves to the target area; each air-coupled ultrasonic transducer is sheet-shaped; and the control system is electrically connected to the penetration-enhancing shell and is used to send a control instruction to each air-coupled ultrasonic transducer to instruct each air-coupled ultrasonic transducer to transmit ultrasonic waves. The penetration-enhancing system based on an ultrasonic transducer of the present application does not need to be in direct contact with the site of action, nor does it need to ensure close contact with the target site. Ultrasonic waves can be applied to the surface or deep part of human skin, thereby increasing the absorption rate of skin care products or drugs and improving the efficacy of skin care products or drugs. By setting up an air-coupled ultrasonic transducer, the risks of poor penetration effect and skin damage caused by the loose fit of existing ultrasonic penetration-enhancing products are avoided, thereby improving the safety and penetration effect of ultrasound-enhanced drug percutaneous penetration.

[0050] Optionally, according to an ultrasonic transducer-based penetration enhancement system provided by the present application, the ultrasonic transducer-based penetration enhancement system further includes at least one LED lamp bead. FIG2 is a second structural schematic diagram of the ultrasonic transducer-based penetration enhancement system provided by the present application. As shown in FIG2 , the ultrasonic transducer-based penetration enhancement system of the embodiment of the present application may further include a plurality of LED lamp beads 40.

[0051] Specifically, a plurality of LED lamp beads are evenly arranged around each of the air-coupled ultrasonic transducers.

[0052] Optionally, according to the ultrasonic transducer-based penetration enhancement system provided in the present application, the ultrasonic transducer-based penetration enhancement system further includes at least one heating device. As shown in FIG2 , the ultrasonic transducer-based penetration enhancement system of the embodiment of the present application may further include multiple heating devices 50 .

[0053] Specifically, LED lamp beads and heating devices can be alternately arranged at intervals of 2-10 mm between different air-coupled ultrasonic transducers 20. The sizes of LED lamp beads and heating devices can be selected to be 1-5 mm so as to facilitate their arrangement between the air-coupled ultrasonic transducers, thereby further enhancing the penetration and absorption of drugs or skin care products and improving the efficacy of drugs or skin care products.

[0054] Optionally, according to an ultrasonic transducer-based permeation promotion system provided by the present application, each of the LED lamp beads and each of the heating devices are evenly arranged around each of the air-coupled ultrasonic transducers.

[0055] Specifically, in the specific implementation of the present application, multiple LED lamp beads and heaters are evenly arranged around each of the air-coupled ultrasonic transducers and can be arranged in an alternating manner.

[0056] The present application provides a penetration-enhancing system based on an ultrasonic transducer, comprising: a penetration-enhancing shell, a wearing device, at least one air-coupled ultrasonic transducer and a control system, wherein the wearing device is arranged outside the penetration-enhancing shell, and each of the air-coupled ultrasonic transducers is arranged inside the penetration-enhancing shell to transmit ultrasonic waves to the target area; each air-coupled ultrasonic transducer is sheet-shaped; and the control system is electrically connected to the penetration-enhancing shell and is used to send a control instruction to each air-coupled ultrasonic transducer to instruct each air-coupled ultrasonic transducer to transmit ultrasonic waves. The penetration-enhancing system based on an ultrasonic transducer of the present application does not need to be in direct contact with the site of action, nor does it need to ensure close contact with the target site. Ultrasonic waves can be applied to the surface or deep part of human skin, thereby increasing the absorption rate of skin care products or drugs and improving the efficacy of skin care products or drugs. By setting up an air-coupled ultrasonic transducer, the risks of poor penetration effect and skin damage caused by the loose fit of existing ultrasonic penetration-enhancing products are avoided, thereby improving the safety and penetration effect of ultrasound-enhanced drug percutaneous penetration.

[0057] Furthermore, by arranging LED lamp beads and heating devices between different air-coupled ultrasonic transducers, the penetration and absorption of drugs or skin care products are further improved, thereby enhancing the efficacy of drugs or skin care products.

[0058] Optionally, according to the ultrasonic transducer-based penetration-enhancing system provided in the present application, the penetration-enhancing shell is of an arch bridge type or a fitted type.

[0059] It should be noted that the penetration-enhancing shell in the penetration-enhancing system based on ultrasonic transducers of the present application will be adjusted according to the specific part of use. For example, when the part of use is the knee, an arch bridge type can be used. When the part of use is the face or waist, the penetration-enhancing shell can be a fitting type.

[0060] Figure 3 is the third structural schematic diagram of the penetration-enhancing system based on ultrasonic transducers provided in the present application. As shown in Figure 3, the penetration-enhancing shell of the penetration-enhancing system based on ultrasonic transducers can be designed in shape according to actual conditions. For example, the arch-bridge-shaped penetration-enhancing shell shown in Figure 3 can be designed in an arch-bridge shape according to the shape of the human waist and legs.

[0061] Specifically, a plurality of air-coupled ultrasonic transducers are provided on the inner surface of the arch-bridge-shaped permeation-promoting shell, and a plurality of LED lamp beads and heating devices are evenly and alternately arranged in the middle of each air ultrasonic transducer.

[0062] The present application provides a penetration-enhancing system based on an ultrasonic transducer, comprising: a penetration-enhancing shell, a wearing device, at least one air-coupled ultrasonic transducer and a control system, wherein the wearing device is arranged outside the penetration-enhancing shell, and each of the air-coupled ultrasonic transducers is arranged inside the penetration-enhancing shell to transmit ultrasonic waves to the target area; each air-coupled ultrasonic transducer is sheet-shaped; and the control system is electrically connected to the penetration-enhancing shell and is used to send a control instruction to each air-coupled ultrasonic transducer to instruct each air-coupled ultrasonic transducer to transmit ultrasonic waves. The penetration-enhancing system based on an ultrasonic transducer of the present application does not need to be in direct contact with the site of action, nor does it need to ensure close contact with the target site. Ultrasonic waves can be applied to the surface or deep part of human skin, thereby increasing the absorption rate of skin care products or drugs and improving the efficacy of skin care products or drugs. By setting up an air-coupled ultrasonic transducer, the risks of poor penetration effect and skin damage caused by the loose fit of existing ultrasonic penetration-enhancing products are avoided, thereby improving the safety and penetration effect of ultrasound-enhanced drug percutaneous penetration.

[0063] Furthermore, the air-coupled transducer does not need to be in direct contact with the site of action, so it can be adapted to the ultrasonic circulator-based penetration enhancement system of the present application. The form of cosmetics can be diversified, and can be used for smears, masks, etc., and there are no requirements for the viscosity of the cosmetics, which expands the application scenarios.

[0064] Furthermore, the penetration-promoting shell in the penetration-promoting system based on the ultrasonic transducer of the embodiment of the present application can be conformally designed to the shape of the ultrasonic penetration-promoting system product according to the shape of different parts, thereby achieving penetration adaptation to various parts such as the face, legs, waist, etc., expanding the scope of application of ultrasonic penetration-promoting products. The auxiliary wearing device can fix the penetration-promoting shell to the introduction part, avoiding the operator's fatigue from repeated hand-held circular operations, and also solving the problem of rapid evaporation of skin care products caused by repeated circular operations of the handheld introduction instrument and the need for continuous replenishment of skin care products.

[0065] Optionally, according to the ultrasonic transducer-based penetration enhancement system provided in the present application, the wearing device is a fixing device that fits the physiological skin.

[0066] Specifically, in a specific implementation, the shape of the penetration-promoting shell in the penetration-promoting system based on an ultrasonic transducer is not fixed. It can be designed accordingly according to the shape of the part that actually needs to be promoted, and is presented in the form of a mask on the penetration-promoting shell. The wearing device is in the form of an ear hook, which is arranged on the outside of the penetration-promoting shell, and there are two of them. In a specific implementation, if the part to be promoted is not the face, the shape of the corresponding penetration-promoting shell can also be changed. For example, if the target part of the penetration is a flat part, the shape of the penetration-promoting shell can be an arch bridge type. In this case, the shape of the wearing device corresponding to the penetration-promoting shell will also change.

[0067] Furthermore, the material of the wearing device can be a fixing device that fits physiological skin, which can help improve the comfort of the skin in the target area that contacts the wearing device.

[0068] The present application provides a penetration-enhancing system based on an ultrasonic transducer, comprising: a penetration-enhancing shell, a wearing device, at least one air-coupled ultrasonic transducer, and a control system. The wearing device is arranged outside the penetration-enhancing shell, and each of the air-coupled ultrasonic transducers is arranged inside the penetration-enhancing shell to transmit ultrasonic waves to the target area; each air-coupled ultrasonic transducer is sheet-shaped; the control system is electrically connected to the penetration-enhancing shell and is used to send control instructions to each air-coupled ultrasonic transducer to instruct each air-coupled ultrasonic transducer to transmit ultrasonic waves. The shape of the penetration-enhancing shell in the penetration-enhancing system based on an ultrasonic transducer of the present application can be adjusted based on the actual site of action, and is equipped with a fixing device that fits the physiological skin, thereby improving the usability of the system.

[0069] Optionally, according to the ultrasonic transducer-based permeation enhancement system provided by the present application, the control system is also used to adjust the ultrasonic energy and operating frequency of each of the air-coupled ultrasonic transducers.

[0070] Specifically, while instructing each air-coupled ultrasonic transducer to emit ultrasonic waves, the control instructions can also control the ultrasonic energy intensity, emission frequency, and emission time of the ultrasonic waves emitted by each air-coupled ultrasonic transducer. For example, the control system drives the air-coupled ultrasonic transducer to emit ultrasonic waves to the target site and continuously act for a period of time. Specifically, the ultrasonic waves can be continuously emitted at the target site for 1-50 minutes, preferably 5-30 minutes. The ultrasonic energy intensity is about 0.1-2W / cm2. In order to achieve a better ultrasonic permeation effect, the frequency of the air-coupled ultrasonic transducer 20 can be selected between 20kHz and 5MHz. The mechanical effect, sonoporous effect, cavitation effect, etc. of ultrasonic waves in biological tissues are used to destroy cell membranes, form drug molecule channels, and promote the absorption of chemical reagents or drugs.

[0071] The present application also provides an ultrasonic transducer-based penetration enhancement method, which is applied to any of the ultrasonic transducer-based penetration enhancement systems described above. FIG4 is a flow chart of the ultrasonic transducer-based penetration enhancement method provided by the present application. As shown in FIG4 , the ultrasonic transducer-based penetration enhancement method of the embodiment of the present application includes the following steps:

[0072] Step 410: receiving a penetration-enhancing instruction;

[0073] Specifically, a receiving module can be set in the control module of the ultrasonic transducer-based permeation promotion system. The function of the receiving module is human-computer interaction, and it receives the permeation promotion instructions sent by the user. Specifically, the user can select the permeation promotion type and permeation promotion parameters on the front display screen.

[0074] Step 420: Based on the penetration-enhancing instruction, a control instruction is sent to each of the air-coupled ultrasonic transducers; the control instruction is used to instruct each of the air-coupled ultrasonic transducers to emit ultrasonic waves.

[0075] Furthermore, based on the penetration-enhancing instruction sent by the user received by the receiving module, a control instruction is sent to the multiple air-coupled ultrasonic transducers, the control instruction being used to instruct each air-coupled ultrasonic transducer to emit ultrasonic waves toward the target area. It should also be noted that after the air-coupled ultrasonic transducers receive the control instruction and begin operating, the LED lamp beads and heating devices arranged between the air-coupled ultrasonic transducers will begin to operate in sequence.

[0076] It should be noted that the ultrasonic transducer is used to open the channel of the target skin area, the LED lamp beads are used for cosmetic effects, and the heating device is used to promote the absorption of cosmetics in the target skin area after applying cosmetics to the target skin area.

[0077] Furthermore, based on the penetration-promoting instruction, the ultrasonic energy intensity, operating frequency, and emission time emitted by the air-coupled ultrasonic transducer can also be controlled by control instructions.

[0078] The ultrasonic transducer-based penetration promotion method of the embodiment of the present application is implemented on a penetration promotion system based on an ultrasonic transducer. By receiving the penetration promotion instructions issued by the user, a control instruction is issued to the air-coupled ultrasonic transducer provided on the penetration promotion shell, instructing the air-coupled ultrasonic transducer to transmit ultrasonic waves to the skin of the target area, and the ultrasonic energy, emission frequency and action time can be controlled, thereby improving the flexibility of the penetration promotion work and the practicality of ultrasonic penetration promotion.

[0079] Furthermore, the specific method of using the ultrasonic transducer-based penetration enhancement system provided in the embodiment of the present application is described as follows:

[0080] When using the ultrasonic transducer-based penetration enhancement system of the embodiment of the present application, the drug agent or skin care product to be introduced can be evenly applied to the target action area first, such as niacinamide, sodium hyaluronate, amino acids, carnosine, etc. Taking the target action area as the face as an example, an ordinary drug mask or application of agents and skin care products can be applied to the face, and no specific limitation is made here.

[0081] Furthermore, the ultrasonic transducer-based penetration-enhancing system is worn on the target area. Specifically, the penetration-enhancing shell is placed on top of a common medicated facial mask and can be fixed with a wearing device. The user then selects the corresponding penetration-enhancing type and penetration-enhancing parameters through the front-end display, that is, selects the appropriate ultrasonic energy, and issues a penetration-enhancing instruction.

[0082] The controller of the ultrasonic transducer-based penetration-enhancing system, after receiving the penetration-enhancing instruction, sends a control instruction to the air-coupled ultrasonic transducer in the ultrasonic transducer-based penetration-enhancing system, and the air-coupled ultrasonic transducer transmits ultrasonic waves to the skin area to be introduced. For example, the ultrasonic waves can be continuously emitted at the target site for 1-50 minutes, preferably 5-30 minutes, and the ultrasonic energy intensity is about 0.1-2W / cm2. In order to achieve a better ultrasonic penetration-enhancing effect, the frequency of the air-coupled ultrasonic transducer 20 can be selected between 20kHz and 5MHz, and the mechanical effect, cavitation effect, sonoporous effect, thermal effect, etc. of the ultrasonic wave and biological tissue are used to open the skin stratum corneum. In addition, when the air-coupled ultrasonic transducer starts working, the LED lamp beads and heating devices arranged between the air-coupled ultrasonic transducers will also start working to assist the introduction and penetration, thereby promoting the absorption of drug agents or skin care products.

[0083] It should be noted that in actual use, the above-mentioned usage method can be flexibly changed in order. That is, it can be directly worn on the face or the target area to be introduced without applying pharmaceutical agents or skin care products, nor applying a medicated mask. The ultrasonic energy intensity is adjusted to about 0.1-2W / cm2. After the ultrasonic wave is introduced into the skin for a period of time, the ultrasonic wave action time is about 5-30 minutes. The mechanical effect, cavitation effect, sonoporation effect, thermal effect and other biological effects of ultrasound in biological tissues are used to open the skin stratum corneum and ion channels. After use, the pharmaceutical agent or skin care product is evenly applied on the target skin.

[0084] The ultrasonic transducer-based penetration enhancement system of the embodiment of the present application, in addition to applying the medicine first and then using the penetration enhancement system, can also be worn directly on the face, and after the stratum corneum channel is opened, the drug agent or skin care product can be applied or a drug mask can be applied. This can achieve rapid transdermal absorption of the drug agent or skin care product, reduce the repeated application of supplementary skin care products during the introduction process, and eliminate the traditional subsequent operation of applying skin care products again to repair the stratum corneum barrier. It saves time, reduces the complexity of ultrasonic penetration introduction, avoids the multiple use of drug agents or skin care products, reduces the cost of ultrasonic introduction penetration enhancement, and has a wide applicability and can be applied to skin care products of different types, different forms, and different absorption or volatilization rates.

[0085] Figure 5 is a schematic diagram of the structure of an electronic device provided in this application. Figure 5 illustrates a schematic diagram of the physical structure of an electronic device. As shown in Figure 5, the electronic device may include: a processor 510, a communication interface 520, a memory 530 and a communication bus 540, wherein the processor 510, the communication interface 520, and the memory 530 communicate with each other through the communication bus 540. The processor 510 can call the logic instructions in the memory 530 to execute the above-mentioned ultrasonic transducer-based penetration enhancement method, which includes:

[0086] receiving penetration-enhancing instructions;

[0087] Based on the penetration-enhancing instruction, a control instruction is sent to each of the air-coupled ultrasonic transducers; the control instruction is used to instruct each of the air-coupled ultrasonic transducers to emit ultrasonic waves.

[0088] In addition, the logic instructions in the above-mentioned memory 830 can be implemented in the form of a software functional unit and can be stored in a computer-readable storage medium when sold or used as an independent product. Based on this understanding, the technical solution of the present application, or the part that contributes to the prior art, or the part of the technical solution, can be embodied in the form of a software product, which is stored in a storage medium and includes several instructions for enabling a computer device (which can be a personal computer, a server, or a network device, etc.) to execute all or part of the steps of the method described in each embodiment of the present application. The aforementioned storage medium includes: various media that can store program codes, such as a USB flash drive, a mobile hard disk, a read-only memory (ROM), a random access memory (RAM), a magnetic disk or an optical disk.

[0089] On the other hand, the present application also provides a computer program product, which includes a computer program. The computer program can be stored on a non-transitory computer-readable storage medium. When the computer program is executed by a processor, the computer can perform the ultrasonic transducer-based penetration enhancement method provided by the above methods, which includes:

[0090] receiving penetration-enhancing instructions;

[0091] Based on the penetration-enhancing instruction, a control instruction is sent to each of the air-coupled ultrasonic transducers; the control instruction is used to instruct each of the air-coupled ultrasonic transducers to emit ultrasonic waves.

[0092] In another aspect, the present application further provides a non-transitory computer-readable storage medium having a computer program stored thereon, which, when executed by a processor, is implemented to perform the ultrasonic transducer-based penetration enhancement method provided by the above methods, the method comprising:

[0093] receiving penetration-enhancing instructions;

[0094] Based on the penetration-enhancing instruction, a control instruction is sent to each of the air-coupled ultrasonic transducers; the control instruction is used to instruct each of the air-coupled ultrasonic transducers to emit ultrasonic waves.

[0095] The device embodiments described above are merely illustrative. The units described as separate components may or may not be physically separate, and the components shown as units may or may not be physical units, i.e., they may be located in one location or distributed across multiple network units. Some or all of the modules may be selected based on actual needs to achieve the objectives of the present embodiment. Persons of ordinary skill in the art will be able to understand and implement the present invention without inventive effort.

[0096] Through the description of the above embodiments, those skilled in the art can clearly understand that each embodiment can be implemented by means of software plus a necessary general hardware platform, or of course, by hardware. Based on this understanding, the essence of the above technical solution or the part that contributes to the existing technology can be embodied in the form of a software product. The computer software product can be stored in a computer-readable storage medium, such as ROM / RAM, a magnetic disk, an optical disk, etc., and includes a number of instructions for enabling a computer device (which can be a personal computer, a server, or a network device, etc.) to execute the methods described in each embodiment or certain parts of the embodiments.

[0097] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present application, rather than to limit them. Although the present application has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present application.

Claims

1. An ultrasound transducer-based transdermal drug delivery system, comprising: An enhanced permeability shell, a wearing device, at least one air-coupled ultrasonic transducer, and a control system, wherein: The wearing device is arranged outside the enhanced permeability shell; Each of the air-coupled ultrasonic transducers is arranged inside the enhanced permeability shell and is used for emitting ultrasonic waves to a target area; each of the air-coupled ultrasonic transducers is in a sheet shape; The control system is electrically connected to the enhanced permeability shell and is used for sending control instructions to each of the air-coupled ultrasonic transducers; the control instructions are used for instructing each of the air-coupled ultrasonic transducers to emit ultrasonic waves.

2. The ultrasound transducer-based penetration enhancement system according to claim 1, wherein, The enhanced permeability system based on ultrasonic transducers further includes at least one LED lamp bead.

3. The ultrasound transducer-based penetration enhancing system according to claim 1 or 2, wherein, The enhanced permeability system based on ultrasonic transducers further includes at least one heating device.

4. The ultrasound transducer-based penetration enhancement system according to claim 3, wherein, Each of the LED lamp beads and each of the heating devices are uniformly arranged around each of the air-coupled ultrasonic transducers.

5. The ultrasound transducer-based transdermal drug delivery system according to any one of claims 1 to 4, wherein The enhanced permeability shell is in an arch shape or a conforming shape.

6. The ultrasound transducer-based permeation enhancement system according to any one of claims 1 to 5, wherein, The wearing device is a fixed structure that conforms to the physiological skin.

7. The ultrasound transducer-based penetration enhancement system according to any one of claims 1 to 6, wherein, The control system is further used for adjusting the ultrasonic energy and working frequency of each of the air-coupled ultrasonic transducers.

8. An enhanced permeability method based on ultrasonic transducers, applied to the enhanced permeability system based on ultrasonic transducers according to any one of claims 1-7, includes: Receiving an enhanced permeability instruction; Based on the enhanced permeability instruction, sending control instructions to each of the air-coupled ultrasonic transducers; The control instructions are used for instructing each of the air-coupled ultrasonic transducers to emit ultrasonic waves.

9. An electronic device, comprising a memory, a processor, and a computer program stored on the memory and executable on the processor, wherein, The processor implements the enhanced permeability method based on ultrasonic transducers according to claim 8 when executing the program.

10. A non-transitory computer-readable storage medium having a computer program stored thereon, wherein, The computer program implements the enhanced permeability method based on ultrasonic transducers according to claim 8 when executed by the processor.

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