Fragrance composition for sleep improvement and cosmetic for sleep improvement
A fragrance composition with 1,4-dimethoxybenzene, phenethyl alcohol, and linalool, along with optional additives, addresses the inefficacy of existing sleep-enhancing fragrances by reducing sleep latency and enhancing sleep quality through chemical synthesis.
Patent Information
- Application Number
- PCT/JP2024/044165
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2023-12-27
- Filing Date
- 2024-12-13
- Publication Date
- 2025-07-03
AI Technical Summary
Existing fragrance compositions do not effectively improve sleep quality, particularly in terms of sleep induction time and efficiency, despite the known effects of aroma components on sleep.
A fragrance composition comprising specific ratios of 1,4-dimethoxybenzene, phenethyl alcohol, linalool, and optionally β-dihydroionone, anisaldehyde, indole, and vanillin, derived from chemical synthesis, which are blended to enhance sleep improvement effects.
The composition significantly reduces sleep latency by an average of 15% and provides an orchid-like fragrance, improving sleep onset and overall sleep quality.
Smart Images

Figure JP2024044165_03072025_PF_FP_ABST
Abstract
Description
Fragrance composition for improving sleep and cosmetic for improving sleep
[0001] The present invention relates to a fragrance composition for improving sleep and a cosmetic for improving sleep.
[0002] Scents are known to affect the quality of sleep.
[0003] For example, in Patent Document 1, the inventors have investigated the physiological effects of sleep-improving effects, such as shortening the time it takes to fall asleep and wake up, and improving sleep efficiency, using aroma components extracted from black teas. As a result, they have found that hotrienol or an aroma component containing specific proportions of (A) citrus flower-like aroma components, (B) sweet flower-like aroma components, (C) mellow flower-like aroma components, (D) woody-like aroma components, (E) green-like aroma components, and (F) cool-like aroma components exhibit extremely high sleep-improving effects.
[0004] Non-Patent Document 1 presents the results of an analysis of the fragrant components of actual orchid flowers. Non-Patent Document 1 shows that the fragrant component composition of, for example, Cattleya intermedia, a type of orchid, is composed of a large number of fragrant components, with the following fragrant components being the major components: 1,4-dimethoxybenzene 24.326 parts by mass, turns-β-ocimene 14.472 parts by mass, (E,E)-α-farnesene 7.958 parts by mass, β-myrcene 6.099 parts by mass, and cis-β-ocimene 4.166 parts by mass.
[0005] International Publication No. 2020 / 059808
[0006] "Fragrance Components and Their Effects in Orchids II: The Aroma of Cattleya Genus," AROMA RESEARCH No. 43 (Vol. 11 / No. 3 2010)
[0007] The present invention provides a novel fragrance composition for improving sleep and a novel cosmetic for improving sleep.
[0008] After extensive research, the present inventors have found that the above-mentioned problems can be solved by the following means, and have thus completed the present invention. Specifically, the present invention is as follows: <Aspect 1> A fragrance composition for improving sleep, comprising the following aroma components in the following mass ratios: 500 parts by mass of 1,4-dimethoxybenzene, 50 to 300 parts by mass of phenethyl alcohol, and 20 to 250 parts by mass of linalool. <Aspect 2> The fragrance composition according to Aspect 1, in which one or more of the 1,4-dimethoxybenzene, the phenethyl alcohol, and the linalool are derived from chemical synthesis. <Aspect 3> The fragrance composition according to Aspect 1 or 2, further comprising one or more of the following aroma components in the following parts by mass: 1 to 50 parts by mass of β-dihydroionone, 1 to 10 parts by mass of anisaldehyde, 0.1 to 5 parts by mass of indole, and 0.1 to 5 parts by mass of vanillin. Aspect 4: The fragrance composition according to any one of Aspects 1 to 3, wherein the sleep improvement is improvement in sleep onset. Aspect 5: The fragrance composition according to any one of Aspects 1 to 4, housed in a container or package bearing a label indicating that the composition is for improving sleep and / or for improving sleep onset. Aspect 6: The fragrance composition according to any one of Aspects 1 to 5, housed in a container or package bearing a label indicating that the composition is for improving sleep. Aspect 7: A cosmetic for improving sleep, comprising the fragrance composition according to any one of Aspects 1 to 4. Aspect 8: The cosmetic according to Aspect 7, wherein the sleep improvement is improvement in sleep onset. Aspect 9: The cosmetic according to Aspect 7 or 8, housed in a container or package bearing a label indicating that the composition is for improving sleep and / or for improving sleep onset. Aspect 10: The cosmetic according to any one of Aspects 7 to 9, housed in a container or package bearing a label indicating that the cosmetic is for improving sleep.
[0009] The present invention provides a novel fragrance composition for improving sleep and a cosmetic for improving sleep. In particular, the fragrance composition for improving sleep of the present invention can achieve a sleep-improving effect and / or provide an orchid-like scent by blending a small number of relatively easily available fragrance components, particularly fragrance components derived from chemical synthesis.
[0010] Fig. 1 is a graph showing the results of a questionnaire about the samples of the Example and the Reference Example. Fig. 2 is a graph showing the results of sleep onset latency measurement about the samples of the Example and the Reference Example.
[0011] The fragrance composition for improving sleep of the present invention contains the following fragrance components in the following mass ratio: 500 parts by mass of 1,4-dimethoxybenzene, 50 to 300 parts by mass, particularly 100 to 250 parts by mass, more particularly 100 to 200 parts by mass of phenethyl alcohol, and 20 to 250 parts by mass, particularly 50 to 200 parts by mass, more particularly 100 to 150 parts by mass of linalool.
[0012] The sleep-improving fragrance composition of the present invention can achieve a sleep-improving effect, particularly an effect of improving sleep onset, and / or can provide an orchid-like scent by blending a small number of relatively easily available fragrance ingredients, particularly fragrance ingredients of chemical synthesis origin. Specifically, one or more of 1,4-dimethoxybenzene, phenethyl alcohol, and linalool, particularly all of these, may be of chemical synthesis origin.
[0013] In the present invention, the term "fragrance component of chemical synthesis origin" is used to encompass both fragrance components that have been chemically totally synthesized and semi-synthesized fragrance components that are obtained by chemically treating extracts from natural products such as plants, and particularly refers to fragrance components that have been chemically totally synthesized.
[0014] Furthermore, the sleep-improving fragrance composition of the present invention may further contain one or more of the following fragrance components in the following parts by mass: β-dihydroionone 1 to 50 parts by mass, particularly 3 to 30 parts by mass, more particularly 5 to 20 parts by mass, anisaldehyde 1 to 10 parts by mass, particularly 2 to 8 parts by mass, more particularly 3 to 7 parts by mass, indole 0.1 to 5 parts by mass, particularly 0.3 to 3 parts by mass, more particularly 0.5 to 2 parts by mass, and vanillin 0.1 to 5 parts by mass, particularly 0.3 to 3 parts by mass, more particularly 0.5 to 2 parts by mass.
[0015] The sleep-improving fragrance composition of the present invention may further contain any component other than the above-mentioned fragrance component, as long as the component does not interfere with the effects of the sleep-improving fragrance composition. In particular, the sleep-improving fragrance composition of the present invention may contain any component other than the above-mentioned fragrance component that can promote and / or regulate the volatilization of the fragrance component. For example, the component other than the fragrance component may be a component known to be odorless, such as dipropylene glycol (DPG).
[0016] When using the fragrance composition for improving sleep of the present invention, the fragrance composition of the present invention can be dissolved in a solvent that can dissolve the fragrance composition of the present invention, or the fragrance of the present invention can be dispersed or floated in a liquid medium that does not dissolve the fragrance composition of the present invention, such as water or hot water.
[0017] Furthermore, the diffusion of the fragrance composition of the present invention itself, or the fragrance composition of the present invention combined with the above-mentioned solvent or liquid medium (hereinafter referred to as the "fragrance composition of the present invention, etc.") can be promoted using an aroma diffuser. Aroma diffusers can be used that naturally vaporize the fragrance composition of the present invention, or that vaporize it by heating, ultrasonic waves, airflow, spraying, or a combination thereof. Aroma diffusers that retain the fragrance composition of the present invention can be retained in a liquid state, or by retaining the fragrance composition impregnated in a fabric such as a nonwoven fabric, a stick made of a porous material such as wood, or a plate made of a porous inorganic material such as diatomaceous earth.
[0018] In order to effectively utilize the sleep-improving effect of the fragrance composition of the present invention, the fragrance composition of the present invention can be used for sleep learning, for example, in a bedroom. The fragrance composition of the present invention can be used not only by individuals at home but also in accommodation facilities such as hotels to provide a good sleeping space.
[0019] Furthermore, the sleep-improving fragrance composition of the present invention can be incorporated into cosmetics such as lotions, milky lotions, and creams to obtain the sleep-improving cosmetics of the present invention.
[0020] The sleep-improving fragrance composition and sleep-improving cosmetic of the present invention can be housed in a container or package bearing a label indicating that it is for improving sleep and / or for improving sleep onset, thereby making it clear that the sleep-improving fragrance composition and sleep-improving cosmetic of the present invention are for improving sleep and / or for improving sleep onset.
[0021] Furthermore, the sleep-improving fragrance composition and sleep-improving cosmetic of the present invention can be housed in a container or package bearing a label indicating that it has an orchid-like scent, thereby clearly indicating that the sleep-improving fragrance composition and sleep-improving cosmetic of the present invention have an orchid-like scent.
[0022] Evaluation Method In the samples of the examples, fragrance compositions having the following composition were used: 1,4-dimethoxybenzene 500 parts by mass, phenethyl alcohol 150 parts by mass, linalool 120 parts by mass, β-dihydroionone 10 parts by mass, anisaldehyde 5 parts by mass, indole 1 part by mass, vanillin 1 part by mass, dipropylene glycol (DPG), balance, total 1000 parts by mass.
[0023] 10 parts by mass of the fragrance composition described above was dissolved in the following room fragrance base and used as a sample in the example: water 13 parts by mass, 95% ethanol 45 parts by mass, 1,3-butylene glycol 32 parts by mass.
[0024] The reference sample was the same as the example sample, except that 95% ethanol was used instead of the fragrance composition (10 parts by mass).
[0025] The samples of the Examples and Reference Examples were evaluated for their sleep improvement effect using the following experimental protocol: Subjects: Men and women (10 people) in their 20s to 50s. Experimental date: The sample of the Reference Example was evaluated for one week, followed by the sample of the Examples for one week. Note that for both the sample of the Reference Example and the sample of the Examples, only data from three days, Tuesday, Wednesday, and Thursday, when lifestyle habits are stable, was used. Fragrance presentation: Cotton soaked in an appropriate amount of the sample was placed in the subject's bedroom from the time they went to bed until they woke up, and the scent was naturally dispersed throughout the room. Psychological indicators: Questionnaire upon waking up. Physiological / behavioral indicators: Sleep onset latency measured using a smartphone app (5 people).
[0026] The questionnaire was administered upon waking up in a visual analogue scale (VAS) format, with "agree" being "100" and "disagree" being "0."
[0027] <Evaluation Results> For the following questions, significant differences (p value less than 0.05) were found between the Example sample and the Reference Example sample, and for all of them, the Example sample provided favorable results (the results are also shown in Figure 1): "Overall, I slept well." "I feel refreshed in the morning." "Overall, I feel good in the morning." "I feel clear-headed when I wake up in the morning."
[0028] Furthermore, sleep onset latency measurements using a smartphone app as a physiological and behavioral indicator showed that the sample of the example reduced sleep onset time by an average of 15% compared to the sample of the reference example. In other words, the physiological and behavioral indicators confirmed that the sample of the example had an effect of improving sleep onset (the results are also shown in Figure 2).
[0029] <Fragrance note evaluation> Three expert panelists evaluated the fragrance notes of the samples of the examples, and all of them confirmed that the fragrance notes were orchid-like.
Claims
1. A fragrance composition for improving sleep, containing the following fragrance components in the following mass ratios: 1,4-dimethoxybenzene: 500 parts by mass, phenethyl alcohol: 50 to 300 parts by mass, and linalool: 20 to 250 parts by mass.
2. The fragrance composition according to claim 1, wherein one or more of the 1,4-dimethoxybenzene, the phenethyl alcohol, and the linalool are of chemically synthesized origin.
3. The fragrance composition according to claim 1 or 2, further containing one or more of the following fragrance components in the following parts by mass: β-dihydroionone: 1 to 50 parts by mass, anisaldehyde: 1 to 10 parts by mass, indole: 0.1 to 5 parts by mass, and vanillin: 0.1 to 5 parts by mass.
4. The fragrance composition according to any one of claims 1 to 3, wherein the improvement in sleep is improvement in falling asleep.
5. The fragrance composition according to any one of claims 1 to 4, contained in a container or package having a label indicating that it is for improving sleep and / or a label indicating that it is for improving falling asleep.
6. The fragrance composition according to any one of claims 1 to 5, contained in a container or package having a label indicating a floral tone.
7. A cosmetic for improving sleep, containing the fragrance composition according to any one of claims 1 to 4.
8. The cosmetic according to claim 7, wherein the improvement in sleep is improvement in falling asleep.
9. The cosmetic according to claim 7 or 8, contained in a container or package having a label indicating that it is for improving sleep and / or a label indicating that it is for improving falling asleep.
10. The cosmetic according to any one of claims 7 to 9, contained in a container or package having a label indicating a floral tone.
Citation Information
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