Pyrazole compounds for combating phytopathogenic fungi

Abstract

The present invention relates to a compound of formula (I), wherein, B, D, R1a, R2, R3, R4, R10, R11 and Z1-Z3 are as defined in the detailed description and to a process for preparing the compound of formula (I). The present invention also relates to a method for combating phytopathogenic fungi.

Description

[0001] Tile: PYRAZOLE COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI FIELD OF THE INVENTION: The present invention relates to novel fungicidal pyrazole compounds of formula (I) which are useful in combating phytopathogenic fungi, and to a process for preparing these novel pyrazole compounds of formula (I). The present invention also relates to compositions and to combinations comprising these novel pyrazole compounds of formula (I) and to a method for combating phytopathogenic fungi using the same. BACKGROUND OF THE INVENTION: Pyrazole-based compounds are described as fungicidal agents in WO2023012044 and WO2023110871. The pyrazole based compounds reported in the above cited literature have disadvantages in certain aspects, such as that they exhibit a narrow spectrum of efficacy or that they do not have a satisfactory fungicidal activity, particularly at low application rates. Therefore, the need remains for the development of new fungicidal compounds, which can be effective against a broader spectrum of fungi, having a lower toxicity, a higher selectivity, and being used at lower dosage rates to reduce or avoid unfavorable environmental or toxicological effects whilst still allowing an effective and long-lasting control of said fungi. Therefore, it is an objective of the present invention to provide compounds having an improved / enhanced activity and / or a broader efficacy spectrum against phytopathogenic fungi. This objective is achieved by using a compound of formula (I) of the present invention for combating phytopathogenic fungi. SUMMARY OF THE INVENTION: The present invention relates to a compound of formula (I) or an agriculturally acceptable salt, N- oxide, isomer, tautomer or polymorph thereof,

[0002] Formula (I) wherein, D is selected from the group consisting of phenyl or 5- or 6-membered heteroaryl ring, wherein said 5- or 6-membered heteroaryl ring comprises 1, 2, 3 or 4 heteroatoms each independently selected from N, O, and S(O)0-2, and wherein said phenyl or 5- or 6-membered heteroaryl ring may be further substituted with one or more different or identical substituents selected from R1band / or R1c; R1ais selected from the group consisting of hydrogen, halogen, hydroxyl, cyano, nitro, C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, C3-C8- cycloalkyl, C3-C8-halocycloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C2-C6-alkenyloxy, C2-C6- haloalkenyloxy, C2-C6-alkynyloxy, C2-C6-haloalkynyloxy, C3-C6-cycloalkyloxy, C1-C6-alkylthio, C1-C6-haloalkylthio, C3-C6-cycloalkylthio, C1-C6- C1-C6-haloalkylsulphinyl, C1-C6- lkylsulfonyl, C1-C6-haloalkylsulfonyl, -N(R7 a )2, -CO-N 2, -S(O)(R8)=NR9, -N=S(O)(R8)2, - P(O)(R8)2, Si(R8)3, or phenyl which may be optionally substituted with one or more different or identical substituents selected from halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C3-C8-cycloalkyl, C1-C6-alkoxy or C1-C6-haloalkoxy ; R1bis selected from the group consisting of hydrogen, halogen, hydroxyl, cyano, C1-C6-alkyl, C1- C6-haloalkyl, C3-C8-cycloalkyl, C1-C6-alkoxy and C1-C6-haloalkoxy; R1cis selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C8- cycloalkyl, hydroxyl and cyano; R2is selected from the group consisting of hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C3-C8-cycloalkyl, C1-C6-alkoxy, and C1-C6-haloalkoxy; R3is selected from the group consisting of hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-cyanoalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, C3-C8- cycloalkyl, C1-C6-alkoxy, and C1-C6-haloalkoxy; R4is selected from the group consisting of hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C3-C8-cycloalkyl, C1-C6-alkoxy or C1-C6-haloalkoxy; Z1, Z2and Z3are each independently selected from CR5or N; R5is selected from the group consisting of hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy and C3-C8-cycloalkyl; B represents a phenyl ring or a 5- or 6-membered aromatic heterocyclic ring, wherein the 5- or 6- membered aromatic heterocyclic ring comprises 1 to 4 heteroatoms selected from oxygen, nitrogen or S(O)0-2,wherein the ring B is unsubstituted or substituted with one or more different or identical substituents selected from R6; R6can be selected from the group consisting of hydrogen, halogen, cyano, hydroxyl, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C3-C8-cycloalkyl, C3-C8-cycloalkyl, C6-C10-aryl which may be substituent with 1 to 2 same or different substitutent selected from the group consisting of C1-C6-alkyl, C1-C6-haloalkyl, halogen, C1-C6-alkoxy and C1-C6-haloalkoxyl, or - N(R7)2; R7represents hydrogen, C1-C6-alkyl, C3-C8-cycloalkyl, C1-C6-alkylcarbonyl, C3-C8- cycloalkylcarbonyl, C1-C6-alkoxycarbonyl or C1-C6-alkylsulfonyl; R8is selected from the group consisting of hydrogen, halogn, eC1-C6-alkyl, C1-C6-haloalkyl, C2-C6- alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, C3-C8-cycloalkyl, C1-C6-alkoxy and C1-C6-haloalkoxy; R9is selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6-haloalkyl and C3-C8- cycloalkyl; R10and R11are independently selected from hydrogen or C1-C6-alkyl or together can form an oxo group (=O) or a 3- to 6-membered carbocyclic ring; R1aand R1b, optionally together along with the phenyl or 5- or 6-membered heteroaryl ring, may form an 8- to 10-membered bicyclic carbocyclic or heterocyclic ring system that can be optionally substituted with one or more different or identical substituents selected from R1band / or R1c, wherein the bicyclic heterocyclic ring system comprises one or more heteroatoms selected from nitrogen, oxygen or S(O)0-2, and wherein one or more carbon atom of the bicyclic carbocyclic or heterocyclic ring system may be replaced with C(O). The present invention also relates to a process for preparing the compound of formula (I). The compounds of formula (I) have been found to be advantageous over the compounds reported in the literature in either of improved fungicidal activity, broader spectrum of biological efficacy, lower application rates, more favourable biological and / or environmental properties, or enhanced plant compatibility. The present invention further relates to agrochemical compositions comprising a compound of formula (I) or a compound of formula (I) in combination with one or more further pesticidally active substance(s) for controlling and / or preventing plant diseases, particularly caused by phytopathogenic fungi. The present invention still further relates to a method for controlling or preventing an infestation of useful plants by phytopathogenic microorganisms, wherein a fungicidally effective amount of a compound of formula (I), a composition or a combination thereof, is applied to the plants, to parts thereof or the locus thereof. DETAILED DESCRIPTION OF THE INVENTION: DEFINITIONS: The definitions provided herein for the terminologies used in the present disclosure are for illustrative purpose only and in no manner limit the scope of the present invention disclosed in the present disclosure. As used herein, the terms “comprises”, “comprising”, “includes”, “including”, “has”, “having”, “contains”, “containing”, “characterized by” or any other variation thereof, are intended to cover a non-exclusive inclusion, subject to any limitation explicitly indicated. For example, a composition, mixture, process or method that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, mixture, process or method. The transitional phrase “consisting of” excludes any element, step or ingredient not specified. If in the claim, such would close the claim to the inclusion of materials other than those recited except for impurities ordinarily associated therewith. When the phrase “consisting of” appears in a clause of the body of a claim, rather than immediately following the preamble, it limits only the element set forth in that clause; other elements are not excluded from the claim as a whole. The transitional phrase “consisting essentially of” is used to define a composition or method that includes materials, steps, features, components or elements, in addition to those literally disclosed, provided that these additional materials, steps, features, components or elements do not materially affect the basic and novel characteristic(s) of the claimed invention. The term “consisting essentially of” occupies a middle ground between “comprising” and “consisting of”. Further, unless expressly stated to the contrary, “or” refers to an inclusive “or” and not to an exclusive “or”. For example, a condition A “or” B is satisfied by any one of the following: A is true (or present) and B is false (or not present), A is false (or not present) and B is true (or present), and both A and B are true (or present). Also, the indefinite articles “a” and “an” preceding an element or component of the present invention are intended to be nonrestrictive regarding the number of instances (i.e. occurrences) of the element or component. Therefore “a” or “an” should be read to include one or at least one, and the singular word form of the element or component also includes the plural unless the number is obviously meant to be singular. As referred to in this disclosure, the term “invertebrate pests” includes but is not limited to fungi, stramenopiles (oomycetes), bacteria, nematodes, mites, ticks, insects and nematodes of economic importance. In the context of this disclosure “pest control” means inhibition of invertebrate pest development (including necrosis, retarded growth and / or death), and related expressions are defined analogously. The term “agronomic” refers to the production of field crops such as for food, feed and fiber and includes the growth of corn, soybeans and other legumes, rice, cereal (e.g., wheat, oats, barley, rye, rice, maize), leafy vegetables (e.g., lettuce, cabbage, and other cole crops), fruiting vegetables (e.g., tomatoes, pepper, eggplant, crucifers and cucurbits), potatoes, sweet potatoes, grapes, cotton, tree fruits (e.g., pome, stone and citrus), small fruit (berries, cherries) and other specialty crops (e.g., canola, sunflower, olives). The term “nonagronomic” refers to other than field crops, such as horticultural crops (e.g., greenhouse, nursery or ornamental plants not grown in a field), residential, agricultural, commercial and industrial structures, turf (e.g., sod farm, pasture, golf course, lawn, sports field, etc.), wood products, stored product, agro-forestry and vegetation management, public health (i.e. human) and animal health (e.g., domesticated animals such as pets, livestock and poultry, undomesticated animals such as wildlife) applications. Nonagronomic applications include protecting an animal from an invertebrate parasitic pest by administering a parasiticidally effective (i.e. biologically effective) amount of a compound of the present invention, typically in the form of a composition formulated for veterinary use, to the animal to be protected. As referred to in the present disclosure and claims, the terms “parasiticidal” and “parasiticidally” refers to observable effects on an invertebrate parasite pest to provide protection of an animal from the pest. Parasiticidal effects typically relate to diminishing the occurrence or activity of the target invertebrate parasitic pest. Such effects on the pest include necrosis, death, retarded growth, diminished mobility or lessened ability to remain on or in the host animal, reduced feeding and inhibition of reproduction. These effects on invertebrate parasite pests provide control (including prevention, reduction or elimination) of parasitic infestation or infection of the animal. The meaning of various terms used in the description shall now be illustrated. The term “C1-C6alkyl”, used either alone or in compound words such as “alkylthio” or “haloalkyl” refers to a straight-chain or branched C1to C6alkyl. Non-limiting examples of “C1-C6alkyl” include methyl, ethyl, propyl, 1-methylethyl, butyl, 1-methylpropyl, 2-methylpropyl, 1,1-dimethylethyl, pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, 1-ethylpropyl, hexyl, 1,1- dimethylpropyl, 1,2-dimethylpropyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4- methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3- dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, 1,1,2-trimethylpropyl, 1,2,2- trimethylpropyl, 1-ethyl-1-methylpropyl and l-ethyl-2-methylpropyl or the different isomers. The term “C2-C6-alkenyl”, used either alone or in compound words refers to straight-chain or branched C2 to C6 alkenes. Non-limiting examples of C2-C6-alkenyl include ethenyl, 1-propenyl, 2- propenyl, 1-methylethenyl, 1-butenyl, 2-butenyl, 3-butenyl, 1-methyl-1-propenyl, 2-methyl-l- propenyl, l-methyl-2 -propenyl, 2-methyl-2-propenyl, 1-pentenyl, 2-pentenyl, 3-pentenyl, 4- pentenyl, 1-methyl-1-butenyl, 2-methyl-1-butenyl, 3-methyl-1-butenyl, l-methyl-2-butenyl, 2- methyl-2-butenyl, 3-methyl-2-butenyl, l-methyl-3-butenyl, 2-methyl-3-butenyl, 3-methyl-3- butenyl, 1,1-dimethyl-2-propenyl, 1,2-dimethyl-1-propenyl, 1,2-dimethyl-2 -propenyl, 1-ethyl-1- propenyl, l-ethyl-2-propenyl, 1-hexenyl, 2-hexenyl, 3-hexenyl, 4-hexenyl, 5-hexenyl, 1-methyl-1- pentenyl, 2-methyl-1-pentenyl, 3-methyl-1-pentenyl, 4-methyl-1-pentenyl, 1-methyl-2-pentenyl, 2- methyl-2-pentenyl, 3-methyl-2-pentenyl, 4-methyl-2-pentenyl, l-methyl-3-pentenyl, 2-methyl-3- pentenyl, 3-methyl-3-pentenyl, 4-methyl-3-pentenyl, 1-methyl-4-pentenyl, 2-methyl-4-pentenyl, 3- methyl-4-pentenyl, 4-methyl-4-pentenyl, 1,1-dimethyl-2-butenyl, l,l-dimethyl-3-butenyl, 1,2- dimethyl-l-butenyl, 1,2-dimethyl-2-butenyl, 1,2-dimethyl-3-butenyl, 1,3-dimethyl-1-butenyl, l,3- dimethyl-2-butenyl, l,3-dimethyl-3-butenyl, 2,2-dimethyl-3-butenyl, 2,3-dimethyl-1-butenyl, 2,3- dimethyl-2-butenyl, 2,3-dimethyl-3-butenyl, 3,3-dimethyl-l-butenyl, 3,3-dimethyl-2-butenyl, 1- ethyl-1-butenyl, 1-ethyl-2-butenyl, l-ethyl-3-butenyl, 2-ethyl- 1-butenyl, 2-ethyl-2-butenyl, 2-ethyl- 3-butenyl, l,l,2-trimethyl-2-propenyl, 1-ethyl-l-methyl-2-propenyl, l-ethyl-2-methyl-l-propenyl and l-ethyl-2-methyl-2-propenyl and the different isomers. “Alkenyl” also includes polyenes such as 1,2-propadienyl and 2,4-hexadienyl. This definition also applies to alkenyl as a part of a composite substituent, for example haloalkenyl, alkenyloxy, haloalkenyloxy and the like, unless defined specifically elsewhere. The term “C2-C6-alkynyl”, used either alone or in compound words refers to straight-chain or branched C2to C6alkynes. Non-limiting examples of C2-C6-alkynes include ethynyl, 1-propynyl, 2- propynyl, 1-butynyl, 2-butynyl, 3-butynyl, 1-methyl-2-propynyl, 1-pentynyl, 2-pentynyl, 3- pentynyl, 4-pentynyl, l-methyl-2-butynyl, l-methyl-3-butynyl, 2-methyl-3-butynyl, 3-methyl-l- butynyl, 1,1-dimethyl-2-propynyl, 1-ethyl -2-propynyl, 1-hexynyl, 2-hexynyl, 3-hexynyl, 4- hexynyl, 5-hexynyl, 1-methyl-2-pentynyl, l-methyl-3-pentynyl, 1-methyl-4-pentynyl, 2-methyl-3- pentynyl, 2-methyl-4-pentynyl, 3-methyl-l-pentynyl, 3-methyl-4-pentynyl, 4-methyl-l-pentynyl, 4- methyl-2-pentynyl, 1,1-dimethyl-2-butynyl, l,l-dimethyl-3-butynyl, l,2-dimethyl-3-butynyl, 2,2- dimethyl-3-butynyl, 3,3-dimethyl-l-butynyl, l-ethyl-2-butynyl, l-ethyl-3-butynyl, 2-ethyl-3-butynyl and 1-ethyl-l-methyl-2-propynyl and the different isomers. This definition also applies to alkynyl as a part of a composite substituent, for example haloalkynyl, alkynyloxy, haloalkynyloxy etc., unless specifically defined elsewhere. The term “alkynyl” can also include moieties comprised of multiple triple bonds such as 2,5-hexadiynyl. The term “C3-C8-cycloalkyl” means a saturated carbocyclic ring containing 3 to 8 carbon atoms. Non-limiting examples of C3-C8-cycloalkyl include cyclopropyl, cyclopentyl and cyclohexyl. This definition also applies to cycloalkyl as a part of a composite substituent, for example C3-C8- halocycloalkyl, cycloalkylalkyl etc., unless specifically defined elsewhere. The term “C3-C6-cycloalkoxy”, and “C3-C6-cycloalkylthio” and the like are defined analogously. Non limiting examples of C3-C6-cycloalkoxy or C3-C6-cycloalkylthio include cyclopropyloxy, cyclopentyloxy, cyclohexyloxy, cyclopropylthio, cyclopentylthio and cyclohexylthio. The term “halogen”, either alone or in compound words such as “haloalkyl”, includes fluorine, chlorine, bromine or iodine. Further, when used in compound words such as “C1-C6-haloalkyl”, said C1-C6-alkyl may be partially or fully substituted with halogen atoms which may be the same or different. Non-limiting examples of “C1-C6-haloalkyl” include chloromethyl, bromomethyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoromethyl, trifluoromethyl, chlorofluoromethyl, dichlorofluoromethyl, chlorodifluoromethyl, 1-chloroethyl, 1-bromoethyl, 1- fluoroethyl, 2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 2-chloro-2-fluoroethyl, 2-chloro- 2,2-difluoroethyl, 2,2-dichloro-2-fluoroethyl, 2,2,2-trichloroethyl, pentafluoroethyl, 1,1-dichloro- 2,2,2-trifluoroethyl, and 1,1,1-trifluoroprop-2-yl. The terms “C2-C6-haloalkenyl”, “C2-C6-haloalkynyl” are defined analogously except that, instead of C1-C6-alkyl groups, C2-C6-alkenyl and C2-C6-alkynyl groups are present as a part of the substituent. The term “C1-C6-alkoxy” used either alone or in compound words includes a straight or branched chain C1-C6-alkoxy. Examples of C1-C6-alkoxy include methoxy, ethoxy, propoxy, 1-methylethoxy, butoxy, 1-methylpropoxy, 2-methylpropoxy, 1,1-dimethylethoxy, pentoxy, 1-methylbutoxy, 2- methylbutoxy, 3-methylbutoxy, 2,2-dimethylpropoxy, 1-ethylpropoxy, hexyloxy, 1,1- dimethylpropoxy, 1,2-dimethylpropoxy, 1-methylpentoxy, 2-methylpentoxy, 3-methylpentoxy, 4- methylpentoxy, 1,1-dimethylbutoxy, 1,2-dimethylbutoxy, 1,3-dimethylbutoxy, 2,2-dimethylbutoxy, 2,3-dimethylbutoxy, 3,3-dimethylbutoxy, 1-ethylbutoxy, 2-ethylbutoxy, 1,1,2-trimethylpropoxy, 1,2,2-trimethylpropoxy, 1-ethyl-1-methylpropoxy and l-ethyl-2-methylpropoxy and the different isomers. This definition also applies to alkoxy as a part of a composite substituent, for example haloalkoxy, etc., unless specifically defined elsewhere. The term “C1-C6-haloalkoxy” means straight-chain or branched C1-C6-alkoxy groups where some or all of the hydrogen atoms in these groups may be replaced by halogen atoms as specified above. Non-limiting examples of C1-C6-haloalkoxy include chloromethoxy, bromomethoxy, dichloromethoxy, trichloromethoxy, fluoromethoxy, difluoromethoxy, trifluoromethoxy, chlorofluoromethoxy, dichlorofluoromethoxy, chlorodifluoromethoxy, 1-chloroethoxy, 1- bromoethoxy, 1-fluoroethoxy, 2-fluoroethoxy, 2,2-difluoroethoxy, 2,2,2-trifluoroethoxy, 2-chloro- 2-fluoroethoxy, 2-chloro-2,2-difluoroethoxy, 2,2-dichloro-2-fluoroethoxy, 2,2,2-trichloroethoxy, pentafluoroethoxy and l,l,l-trifluoroprop-2-oxy. This definition also applies to haloalkoxy as a part of a composite substituent, for example haloalkoxyalkyl etc., unless specifically defined elsewhere. The term “C1-C6-alkylthio” includes branched or straight-chain alkylthio moieties with 1 to 6 carbon atoms. Non-limiting examples of C1-C6-alkylthio includes methylthio, ethylthio, propylthio, 1- methylethylthio, butylthio, 1-methylpropylthio, 2-methylpropylthio, 1,1-dimethylethylthio, pentylthio, 1-methylbutylthio, 2-methylbutylthio, 3-methylbutylthio, 2,2-dimethylpropylthio, 1- ethylpropylthio, hexylthio, 1,1-dimethylpropylthio, 1,2-dimethylpropylthio, 1-methylpentylthio, 2- methylpentylthio, 3-methylpentylthio, 4-methylpentylthio, 1,1-dimethylbutylthio, 1,2- dimethylbutylthio, 1,3-dimethylbutylthio, 2,2-dimethylbutylthio, 2,3-dimethylbutylthio, 3,3- dimethylbutylthio, 1-ethylbutylthio, 2-ethylbutylthio, 1,1,2-trimethylpropylthio, 1,2,2- trimethylpropylthio, 1-ethyl-1-methylpropylthio and l-ethyl-2-methylpropylthio and the different isomers. The term “C1-C6-haloalkylthio” means straight-chain or branched C1-C6-alkylthio group where some or all of the hydrogen atoms in these groups may be replaced by halogen atoms as specified above. Non-limiting examples of haloalkylthio include chloromethylthio, bromomethylthio, dichloromethylthio, trichloromethylthio, fluoromethylthio, difluoromethylthio, trifluoromethylthio, chlorofluoromethylthio, dichlorofluoromethylthio, chlorodifluoromethylthio, 1-chloroethylthio, 1- bromoethylthio, 1- fluoroethylthio, 2-fluoroethylthio, 2,2-difluoroethylthio, 2,2,2-trifluoroethylthio, 2-chloro-2- fluoroethylthio, 2-chloro-2,2-difluoroethylthio, 2,2-dichloro-2-fluoroethylthio, 2,2,2- trichloroethylthio, pentafluoroethylthio and l,l,l-trifluoroprop-2-ylthio. This definition also applies to haloalkylthio as a part of a composite substituent, for example haloalkylthioalkyl etc., unless specifically defined elsewhere. The term “C1-C6-alkylsulphinyl” includes branched or straight-chain alkylsulphinyl moiety with 1 to 6 carbon atoms. Non-limiting examples of C1-C6-alkylsulfinyl include methylsulphinyl, ethylsulphinyl, propylsulphinyl, 1-methylethylsulphinyl, butylsulphinyl, 1-methylpropylsulphinyl, 2-methylpropylsulphinyl, 1,1-dimethylethylsulphinyl, pentylsulphinyl, 1-methylbutylsulphinyl, 2- methylbutylsulphinyl, 3-methylbutylsulphinyl, 2,2-dimethylpropylsulphinyl, 1- ethylpropylsulphinyl, hexylsulphinyl, 1,1-dimethylpropylsulphinyl, 1,2- 1-methylpentylsulphinyl, 2-methylpentylsulphinyl, 3-methylpentylsulphinyl, 4- methylpentylsulphinyl, 1,1-dimethylbutylsulphinyl, 1,2-dimethylbutylsulphinyl, 1,3- dimethylbutylsulphinyl, 2,2-dimethylbutylsulphinyl, 2,3-dimethylbutylsulphinyl, 3,3- dimethylbutylsulphinyl, 1-ethylbutylsulphinyl, 2-ethylbutylsulphinyl, 1,1,2- trimethylpropylsulphinyl, 1,2,2-trimethylpropylsulphinyl, 1-ethyl-1-methylpropylsulphinyl and 1- ethyl-2-methylpropylsulphinyl and the different isomers. The term “C1-C6-alkylsulfonyl” includes branched or straight-chain alkylsulfonyl moiety with 1 to 6 carbon atoms. Non-limiting examples of C1-C6-alkylsulfonyl include methylsulfonyl, ethylsulfonyl, propylsulfonyl, 1-methylethylsulfonyl, butylsulfonyl, 1-methylpropylsulfonyl, 2- methylpropylsulfonyl, 1,1-dimethylethylsulfonyl, pentylsulfonyl, 1-methylbutylsulfonyl, 2- methylbutylsulfonyl, 3-methylbutylsulfonyl, 2,2-dimethylpropylsulfonyl, 1-ethylpropylsulfonyl, hexylsulfonyl, 1,1-dimethylpropylsulfonyl, 1,2-dimethylpropylsulfonyl, 1-methylpentylsulfonyl, 2- methylpentylsulfonyl, 3-methylpentylsulfonyl, 4-methylpentylsulfonyl, 1,1-dimethylbutylsulfonyl, 1,2-dimethylbutylsulfonyl, 1,3-dimethylbutylsulfonyl, 2,2-dimethylbutylsulfonyl, 2,3- dimethylbutylsulfonyl, 3,3-dimethylbutylsulfonyl, 1-ethylbutylsulfonyl, 2-ethylbutylsulfonyl, 1,1,2-trimethylpropylsulfonyl, 1,2,2-trimethylpropylsulfonyl, 1-ethyl-1-methylpropylsulfonyl and l-ethyl-2-methylpropylsulfonyl and the different isomers. The term “C1-C6-alkylcarbonyl” includes branched or straight-chain alkylcarbonyl moiety with 1 to 6 carbon atoms. Non-limiting examples of C1-C6-alkylcarbonyl include methylcarbonyl, ethylcarbonyl, propylcarbonyl, 1-methylethylcarbonyl, butylcarbonyl, 1-methylpropylcarbonyl, 2- methylpropylcarbonyl, 1,1-dimethylethylcarbonyl, pentylcarbonyl, 1-methylbutylcarbonyl, 2- methylbutylcarbonyl, 3-methylbutylcarbonyl, 2,2-dimethylpropylcarbonyl, 1-ethylpropylcarbonyl, hexylcarbonyl, 1,1-dimethylpropylcarbonyl, 1,2-dimethylpropylcarbonyl, 1-methylpentylcarbonyl, 2-methylpentylcarbonyl, 3-methylpentylcarbonyl, 4-methylpentylcarbonyl, 1,1- dimethylbutylcarbonyl, 1,2-dimethylbutylcarbonyl, 1,3-dimethylbutylcarbonyl, 2,2- dimethylbutylcarbonyl, 2,3-dimethylbutylcarbonyl, 3,3-dimethylbutylcarbonyl, 1- ethylbutylcarbonyl, 2-ethylbutylcarbonyl, 1,1,2-trimethylpropylcarbonyl, 1,2,2- trimethylpropylcarbonyl, 1-ethyl-1-methylpropylcarbonyl and l-ethyl-2-methylpropylcarbonyl and the different isomers. The term “C6-C10aryl” refers to mono or bicyclic aromatic carbocyclic ring containing 6 to 10 carbon atoms. Non-limiting examples of “C6-C10aryl” includes phenyl, indenyl, indanyl, naphthyl. The term “5- or 6-membered aromatic heterocyclic ring or 5- or 6-membered heteroaromatic ring” refers to a mono cyclic aromatic heterocyclic ring comprising at least one heteroatom selected from nitrogen, oxygen, or suphur or a group selected from S(O) or S(O)2. Non-limiting examples for said term includes furanyl, pyrrolyl, thiophenyl (thienyl), oxazolyl, thiazolyl, imidazolyl, pyrazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, thiadiazolyl, triazolyl, tetrazolyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazinyl etc. The term "heterocyclic ring” includes "aromatic or non-aromatic heterocyclic ring comprising at least one heteroatom selected from N, O, and S(O)0-2. When a compound is substituted with a substituent bearing a subscript that indicates the number of said substituents can exceed 1, said substituents (when they exceed 1) are independently selected from the group of defined substituents. Further, when the subscript m in (R)m indicates an integer ranging from for example 0 to 4 then the number of substituents may be selected from the integers between 0 and 4 inclusive. When a group contains a substituent which can be hydrogen, then, when this substituent is taken as hydrogen, it is recognized that said group is being un-substituted. Optionally substituted groups may be mono- or polysubstituted, where the substituents in the case of polysubstitutions may be the same or different. The embodiments herein and the various features and advantageous details thereof are explained with reference to the non-limiting embodiments in the description. Descriptions of well-known components and processing techniques are omitted so as to not unnecessarily obscure the embodiments herein. The examples used herein are intended merely to facilitate an understanding of ways in which the embodiments herein may be practiced and to further enable those of skilled in the art to practice the embodiments herein. Accordingly, the examples should not be construed as limiting the scope of the embodiments herein. The description of the specific embodiments will so fully reveal the general nature of the embodiments herein that others can, by applying current knowledge, readily modify and / or adapt for various applications such specific embodiments without departing from the generic concept, and, therefore, such adaptations and modifications should and are intended to be comprehended within the meaning and range of equivalents of the disclosed embodiments. It is to be understood that the phraseology or terminology employed herein is for the purpose of description and not of limitation. Therefore, while the embodiments herein have been described in terms of preferred embodiments, those skilled in the art will recognize that the embodiments herein can be practiced with modification within the spirit and scope of the embodiments as described herein. Any discussion of documents, acts, materials, devices, articles and the like that has been included in this specification is solely for the purpose of providing a context for the disclosure. It is not to be taken as an admission that any or all these matters form a part of the prior art base or were common general knowledge in the field relevant to the disclosure as it existed anywhere before the priority date of this application. The numerical values mentioned in the description and the description / claims though might form a critical part of the present invention, any deviation from such numerical values shall still fall within the scope of the present invention if that deviation follows the same scientific principle as that of the present invention disclosed in the present invention. The inventive compound of the present invention may, if appropriate, be present as mixtures of different possible isomeric forms, especially of stereoisomers, for example E and Z, threo and erythro, and also optical isomers, but if appropriate also of tautomers. Both the E and the Z isomers, but also the threo and erythro isomers, and the optical isomers, and any desired mixtures of these isomers and the possible tautomeric forms are disclosed and claimed. The term "polymorph" refers to a particular crystalline form of a chemical compound that can crystallize in different crystalline forms, these forms having different arrangements and / or conformations of the molecules in the crystal lattice. Although polymorphs can have the same chemical composition, they can also differ in composition due to the presence or absence of co- crystallized water or other molecules, which can be weakly or strongly bound in the lattice. Polymorphs can differ in such chemical, physical and biological properties as crystal shape, density, hardness, color, chemical stability, melting point, hygroscopicity, suspensibility, dissolution rate and biological availability. One skilled in the art will appreciate that a polymorph of a compound represented by formula (I), formula (I-A) or Formula (I-B) can exhibit beneficial effects (e.g., suitability for preparation of useful formulations, improved biological performance) relative to another polymorph or a mixture of polymorphs of the same compound represented by formula (I), formula (I-A) or Formula (I-B). The preparation and isolation of a particular polymorph of a compound represented by formula (I), formula (I-A) or Formula (I-B) can be achieved by methods known to those skilled in the art including, for example, crystallization using selected solvents and temperatures. The term “pest” for the purpose of the present disclosure includes but is not limited to fungi, stramenopiles (oomycetes) and bacteria. The term “plant” is understood here to mean all plants and plant populations, such as desired and undesired wild plants or crop plants (including naturally occurring crop plants). Crop plants may be plants which can be obtained by conventional breeding and optimization methods or by biotechnological and genetic engineering methods or combinations of these methods, including transgenic plants and including the plant cultivars which are protectable and non-protectable by plant breeders’ rights. For the purpose of the present disclosure the term “plant” includes a living organism of the kind exemplified by trees, shrubs, herbs, grasses, ferns, and mosses, typically growing in a site, absorbing water and required substances through its roots, and synthesizing nutrients in its leaves by photosynthesis. Examples of “plant” for the purpose of the present invention include but are not limited to agricultural crops such as wheat, rye, barley, triticale, oats or rice; beet, e.g. sugar beet or fodder beet; fruits and fruit trees, such as pomes, stone fruits or soft fruits, e.g. apples, pears, plums, peaches, almonds, cherries, strawberries, raspberries, blackberries or gooseberries; leguminous plants, such as lentils, peas, alfalfa or soybeans; oil plants, such as rape, mustard, olives, sunflowers, coconut, cocoa beans, castor oil plants, oil palms, ground nuts or soybeans; cucurbits, such as squashes, cucumber or melons; fiber plants, such as cotton, flax, hemp or jute; citrus fruit and citrus trees, such as oranges, lemons, grapefruits or mandarins; any horticultural plants, vegetables, such as spinach, lettuce, asparagus, cabbages, carrots, onions, tomatoes, potatoes, cucurbits or paprika; lauraceous plants, such as avocados, cinnamon or camphor; cucurbitaceae; oleaginous plants; energy and raw material plants, such as cereals, corn, soybean, other leguminous plants, rape, sugar cane or oil palm; tobacco; nuts; coffee; tea; cacao; bananas; peppers; vines (table grapes and grape juice grape vines); hop; turf; sweet leaf (also called Stevia); natural rubber plants or ornamental and forestry plants, such as flowers, shrubs, broad-leaved trees or evergreens, e.g. conifers; and on the plant propagation material, such as seeds, and the crop material of these plants. Preferably, the plant for the purpose of the present invention includes but is not limited to cereals, corn, rice, soybean and other leguminous plants, fruits and fruit trees, grapes, nuts and nut trees, citrus and citrus trees, any horticultural plants, cucurbitaceae, oleaginous plants, tobacco, coffee, tea, cacao, sugar beet, sugar cane, cotton, potato, tomato, onions, peppers and vegetables, ornamentals, any floricultural plants and other plants for use of humans and animals. The term “plant parts” is understood to mean all parts and organs of plants above and below the ground. For the purpose of the present disclosure the term plant parts include but is not limited to cuttings, leaves, twigs, tubers, flowers, seeds, branches, roots including taproots, lateral roots, root hairs, root apex, root cap, rhizomes, slips, shoots, fruits, fruit bodies, bark, stem, buds, auxillary buds, meristems, nodes and internodes. The term “locus thereof” includes soil, surroundings of plant or plant parts and equipment or tools used before, during or after sowing / planting a plant or a plant part. Application of the compounds of the present disclosure or the compound of the present disclosure in a composition optionally comprising other compatible compounds to a plant or a plant material or locus thereof includes application by a technique known to a person skilled in the art which includes but is not limited to spraying, coating, dipping, fumigating, impregnating, injecting and dusting. The term “applied” means adhered to a plant or plant part either physically or chemically including impregnation. The present invention relates to a compound of formula (I) or an agriculturally acceptable salt, N- oxide, isomer, tautomer or polymorph thereof, wherein, D is selected from the group consisting of phenyl or 5- or 6-membered heteroaryl ring, wherein said 5- or 6-membered heteroaryl ring comprises 1, 2, 3 or 4 heteroatoms each independently selected from N, O, and S(O)0-2, and wherein said phenyl or 5- or 6-membered heteroaryl ring may be further substituted with one or more different or identical substituents selected from R1band / or R1c; R1ais selected from the group consisting of hydrogen, halogen, hydroxyl, cyano, nitro, C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, C3-C8- cycloalkyl, C3-C8-halocycloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C2-C6-alkenyloxy, C2-C6- haloalkenyloxy, C2-C6-alkynyloxy, C2-C6-haloalkynyloxy, C3-C6-cycloalkyloxy, C1-C6-alkylthio, C1-C6-haloalkylthio, C3-C6-cycloalkylthio, C1-C6-alkylsulphinyl, C1-C6-haloalkylsulphinyl, C1-C6- alkylsulfonyl, C1-C6-haloalkylsulfonyl, -N(R7 )2, -CO- 2, -S(O)(R8)=NR9, -N=S(O)(R8)2, P(O)(R8)2, Si(R8)3 or phenyl which may be optionally substituted with one or more different or identical substituents selected from halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C3-C8-cycloalkyl, C1-C6-alkoxy or C1-C6-haloalkoxy ; R1bis selected from the group consisting of hydrogen, halogen, hydroxyl, cyano, C1-C6-alkyl, C1- C6-haloalkyl, C3-C8-cycloalkyl, C1-C6-alkoxy and C1-C6-haloalkoxy; R1cis selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C8- cycloalkyl, hydroxyl and cyano; R2is selected from the group consisting of hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C3-C8-cycloalkyl, C1-C6-alkoxy, and C1-C6-haloalkoxy; R3is selected from the group consisting of hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-cyanoalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, C3-C8- cycloalkyl, C1-C6-alkoxy, and C1-C6-haloalkoxy; R4is selected from the group consisting of hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C3-C8-cycloalkyl, C1-C6-alkoxy, and C1-C6-haloalkoxy; Z1, Z2and Z3are each independently selected from CR5or N; R5is selected from the group consisting of hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy and C3-C8-cycloalkyl; B represents a phenyl ring or a 5- or 6-membered aromatic heterocyclic ring, wherein the 5- or 6- membered aromatic heterocyclic ring comprises 1 to 4 heteroatoms selected from oxygen, nitrogen or S(O)0-2, wherein the ring B is unsubstituted or substituted with one or more different or identical substituents selected from R6; R6can be selected from the group consisting of hydrogen, halogen, cyano, hydroxyl, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C3-C8-cycloalkyl, C3-C8-cycloalkyl, C6-C10-aryl which may be substituent with 1 to 2 same or different substitutent selected from the group consisting of C1-C6-alkyl, C1-C6-haloalkyl, halogen, C1-C6-alkoxy and C1-C6-haloalkoxyl, or - N(R7)2; R7represents hydrogen, C1-C6-alkyl, C3-C8-cycloalkyl, C1-C6-alkylcarbonyl, C3-C8- cycloalkylcarbonyl, C1-C6-alkoxycarbonyl or C1-C6-alkylsulfonyl; R8is selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C2-C6- alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, C3-C8-cycloalkyl, C1-C6-alkoxy and C1-C6-haloalkoxy; R9is selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6-haloalkyl and C3-C8- cycloalkyl; R10and R11are independently selected from hydrogen or C1-C6-alkyl or together can form an oxo group (=O) or a 3- to 6-membered carbocyclic ring; R1aand R1boptionally together along with the phenyl or 5- or 6-membered heteroaryl ring may form an 8- to 10-membered bicyclic carbocyclic or heterocyclic ring system that can be optionally substituted with one or more different or identical substituents selected from R1band / or R1c, wherein the bicyclic heterocyclic ring system comprises one or more heteroatoms selected from nitrogen, oxygen or S(O)0-2, and wherein one or more carbon atom of the bicyclic carbocyclic or heterocyclic ring system may be replaced with C(O). In a preferred embodiment of the present invention, it provides, a compound of formula (I) or an agriculturally acceptable salt, N-oxide, isomer, tautomer or polymorph thereof, wherein, D is selected from the group consisting of phenyl or 5- or 6-membered heteroaryl ring, wherein said 5- or 6-membered heteroaryl ring comprises 1, 2, 3 or 4 heteroatoms each independently selected from N, O, and S(O)0-2, and wherein said phenyl or 5- or 6-membered heteroaryl ring may be further substituted with one or more different or identical substituents selected from R1band / or R1c; R1ais selected from the group consisting of hydrogen, halogen, hydroxyl, cyano, nitro, C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, C3-C8- cycloalkyl, C3-C8-halocycloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C2-C6-alkenyloxy, C2-C6- haloalkenyloxy, C2-C6-alkynyloxy, C2-C6-haloalkynyloxy, C3-C6-cycloalkyloxy, C1-C6-alkylthio, C1-C6-haloalkylthio, C3-C6-cycloalkylthio, C1-C6-alkylsulphinyl, C1-C6-haloalkylsulphinyl, C1-C6- lkylsulfonyl, C1-C6-haloalkylsulfonyl, -N(R7 a )2, -CO- 2, -S(O)(R8)=NR9, -N=S(O)(R8)2, P(O)(R8)2, Si(R8)3 or phenyl which may be optionally substituted with one or more different or identical substituents selected from halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C3-C8-cycloalkyl, C1-C6-alkoxy or C1-C6-haloalkoxy ; R1bis selected from the group consisting of hydrogen, halogen, hydroxyl, cyano, C1-C6-alkyl, C1- C6-haloalkyl, C3-C8-cycloalkyl, C1-C6-alkoxy and C1-C6-haloalkoxy; R1cis selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C8- cycloalkyl, hydroxyl and cyano; R2is selected from the group consisting of hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C3-C8-cycloalkyl, C1-C6-alkoxy, and C1-C6-haloalkoxy; R3is selected from the group consisting of hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-cyanoalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, C3-C8- cycloalkyl, C1-C6-alkoxy, and C1-C6-haloalkoxy; R4is selected from the group consisting of hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C3-C8-cycloalkyl, C1-C6-alkoxy, and C1-C6-haloalkoxy; Z1, Z2and Z3are each independently selected from CR5or N; R5is selected from the group consisting of hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy and C3-C8-cycloalkyl; B represents a 5-membered aromatic heterocyclic ring, wherein the 5-membered aromatic heterocyclic ring comprises 1 to 4 heteroatoms selected from oxygen, nitrogen or S(O)0-2, wherein the ring B is unsubstituted or substituted with one or more different or identical substituents selected from R6; R6can be selected from the group consisting of hydrogen, halogen, cyano, hydroxyl, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C3-C8-cycloalkyl, C3-C8-cycloalkyl, C6-C10-aryl which may be substituent with 1 to 2 same or different substitutent selected from the group consisting of C1-C6-alkyl, C1-C6-haloalkyl, halogen, C1-C6-alkoxy and C1-C6-haloalkoxyl, or - N(R7)2; R7represents hydrogen, C1-C6-alkyl, C3-C8-cycloalkyl, C1-C6-alkylcarbonyl, C3-C8- cycloalkylcarbonyl, C1-C6-alkoxycarbonyl or C1-C6-alkylsulfonyl; R8is selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C2-C6- alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, C3-C8-cycloalkyl, C1-C6-alkoxy and C1-C6-haloalkoxy; R9is selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6-haloalkyl and C3-C8- cycloalkyl; R10and R11are independently selected from hydrogen or C1-C6-alkyl or together can form an oxo group (=O) or a 3- to 6-membered carbocyclic ring; R1aand R1boptionally together along with the phenyl or 5- or 6-membered heteroaryl ring may form an 8- to 10-membered bicyclic carbocyclic or heterocyclic ring system that can be optionally substituted with one or more different or identical substituents selected from R1band / or R1c, wherein the bicyclic heterocyclic ring system comprises one or more heteroatoms selected from nitrogen, oxygen or S(O)0-2, and wherein one or more carbon atom of the bicyclic carbocyclic or heterocyclic ring system may be replaced with C(O). In another preferred embodiment of the present invention, it provides the compound of formula (I) or an agriculturally acceptable salt, N-oxide, isomer, tautomer or polymorph thereof,

[0003] wherein, B is a 5-membered aromatic heterocyclic ring which can be selected from thiophenyl (thienyl), thiazolyl, isothiazolyl, or thiadiazolyl, wherein each ring is unsubstituted or substituted with one or more same or different substituents selected from R6; and R1a-R1c, R2, R3, R4, R6, R10, R11and Z1-Z3are as defined above for the compound of formula (I). In an embodiment of the present invention, it provides the compound of formula (I) which represents a compound of formula (I-A): wherein n = 1-3, B, R1a-R1c, R2, R3, R4, R10, R11and Z1-Z3are as defined above for the compound of formula (I). In a preferred embodiment of the present invention, it provides the compound of formula (I) which represents a compound of formula (I-B): wherein n = 1-3, preferably n = 1; B is a pyridyl, thiophenyl (thienyl), thiazolyl, isothiazolyl, or thiadiazolyl ring, wherein said ring is unsubstituted or substituted with one or more different or identical substituents selected from R6; and R1a-R1c, R2, R3, R4, R6, R10, R11and Z1-Z3are as defined above for the compound of formula (I). In a more preferred embodiment of the present invention, the compound of formula (I) is a compound of formula (I-B): wherein n = 1-3, preferably n = 1; B is thiophenyl (thienyl), thiazolyl, isothiazolyl, or thiadiazolyl most preferably B is thiazolyl ring or thiophenyl (thienyl) ring, wherein said ring is unsubstituted or substituted with one or more different or identical substituents selected from R6; and R1a-R1c, R2, R3, R4, R6, R10, R11and Z1-Z3are as defined above for the compound of formula (I). In another preferred embodiment of the present invention, it provides the compound of formula (I) which represents a compound of formula (I-C): wherein n = 1-3, preferably n = 1; R1a-R1c, R2, R3, R4, R6, R10, R11and Z1-Z3are as defined above for the compound of formula (I). In another preferred embodiment of the present invention, it provides the compound of formula (I) which represents a compound of formula (I-D): wherein n = 1-3, preferably n = 1; R1a-R1c, R2, R3, R4, R6, R10, R11and Z1-Z3are as defined above for the compound of formula (I). In another preferred embodiment of the present invention, the compound of formula (I-D) is a compound of formula (I-D-a) or formula (I-D-b) or formula (I-D-c): for the compound of formula (I). In another preferred embodiment of the present invention, it provides the compound of formula (I) which represents a compound of formula (I-E): , wherein n = 1-3, preferably n = and Z1-Z3are as defined above for the compound of formula (I). In another preferred embodiment of the present invention, the compound of formula (I-E) is a compound of formula (I-E-a) or formula (I-E-b): wher d above for the compound of formula (I). In yet another preferred embodiment of the present invention, the compound of formula (I), or formula (I-A) to formula (I-E), wherein the ring C is selected from one of the following rings C-1 to C-7: wherein R5 cyano, C1- C6-alkyl, C1-C6-haloalkyl and C3-C8-cycloalkyl, and R5can be same or different in the C-7 imidazolyl ring. In another preferred embodiment of the present invention, the compound of formula (I), or formula (I-A) to formula (I-E) wherein, R1ais selected from the group consisting of hydrogen, halogen, hydroxyl, cyano, nitro, C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, C3-C8- cycloalkyl, C3-C8-halocycloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C2-C6-alkenyloxy, C2-C6- haloalkenyloxy, C2-C6-alkynyloxy, C2-C6-haloalkynyloxy, C3-C6-cycloalkyloxy, C1-C6-alkylthio, C1-C6-haloalkylthio, C3-C6-cycloalkylthio, C1-C6-alkylsulphinyl, C1-C6-haloalkylsulphinyl, C1-C6- alkylsulfonyl, C1-C6-haloalkylsulfonyl, -N(R7)2, -CO-N(R9)2, -S(O)(R8)=NR9, -N=S(O)(R8)2, P(O)(R8)2,Si(R8)3, or phenyl which may be optionally substituted with one or more different or identical substituents selected from halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C3-C8-cycloalkyl , C1-C6-alkoxy or C1-C6-haloalkoxy, ; R1bis selected from the group consisting of hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C3-C8-cycloalkyl, C1-C6-alkoxy and C1-C6-haloalkoxy; R1cis selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C1-C6-haloalkyl, cyano and C3-C8-cycloalkyl; R2is selected from the group consisting of hydrogen, C1-C6-alkyl, and C1-C6-haloalkyl; R3is selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-alkoxy, and C1-C6-haloalkoxy; R4is selected from the group consisting of hydrogen, C1-C6-alkyl and C1-C6-haloalkyl;the ring C is preferably selected from one of the following rings C-1 to C-7: halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl and C3-C8-cycloalkyl and R5can be same or different in the C-7 imidazolyl ring; R6can be selected from the group consisting of hydrogen, halogen, cyano, hydroxyl, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C3-C8-cycloalkyl, or -N(R7)2; R7represents hydrogen, C1-C6-alkyl, C3-C8-cycloalkyl, C1-C6-alkylcarbonyl, or C3-C8- cycloalkylcarbonyl; R8is selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy and C1-C6-haloalkoxy; R9is selected from the group consisting of hydrogen, C1-C6-alkyl and C3-C8-cycloalkyl; R10and R11are independently selected from hydrogen or C1-C6-alkyl; R1aand R1boptionally together along with the phenyl ring may form an 8- to 10-membered bicyclic carbocyclic or heterocyclic ring system that can be optionally substituted with one or more different or identical substituents selected from R1band / or R1c, wherein the bicyclic heterocyclic ring system comprises one or more heteroatoms selected from nitrogen, oxygen or S(O)0-2, and n is 1-3, preferably n = 1-2 and more preferably n = 1. In yet another preferred embodiment of the present invention, the compound of formula (I), or formula (I-A) to formula (I-E) wherein, R1ais selected from the group consisting of hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C3-C8-cycloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C3-C6-cycloalkyloxy, C1-C6-alkylthio, C1-C6- haloalkylthio, or C1-C6-alkylsulfonyl, more preferably fluoro, chloro, bromo, iodo, cyano, methyl, ethyl, isopropyl, trifluoromethyl, methoxy, ethoxy, isopropoxy or cyclopropyl; R1bis selected from the group consisting of hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, and C3-C8-cycloalkyl, more preferably hydrogen, fluoro, chloro, bromo, cyano, methyl, trifluoromethyl or cyclopropyl; R1cis selected from the group consisting of hydrogen, halogen, cyano, C1-C6-alkyl and C1-C6- haloalkyl, more preferably hydrogen, cyano or halogen such as fluoro, chloro or bromo; R2is hydrogen; R3is selected from the group consisting of hydrogen, halogen or C1-C6-alkyl, more preferably hydrogen, chloro or methyl; R4is selected from the group consisting of hydrogen and C1-C6-alkyl, more preferably hydrogen or methyl; the ring C = selected from one of the following rings C-1 to C-7:

[0004] wherein R5is independently selected from the group consisting of hydrogen, halogen, C1- C6-alkyl, C1-C6-haloalkyl, and C3-C8-cycloalkyl and R5can be same or different in the C-7 imidazolyl ring. More preferably hydrogen, chloro, methyl, ethyl, trifluoromethyl and cyclopropyl; R6is selected from hydrogen, halogen or C1-C6-alkyl, more preferably from hydrogen, fluoro, chloro, bromo, or methyl; R10and R11are each independently selected from hydrogen, and n is 1-3, preferably n = 1-2 and more preferably n = 1. In one more preferred embodiment of the present invention, the compound of formula (I) or (I-D) can be selected from a compound of formula (I-D-d), wherein, R2is hydrogen; R3is selected from the group consisting of hydrogen, halogen, and C1-C6-alkyl; R4is selected from C1-C6-alkyl; R6is selected from the group consisting of hydrogen, halogen, and C1-C6-alkyl; R1ais selected from the group consisting of halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C3-C8- cycloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C3-C6-cycloalkyloxy, C1-C6-alkylthio, C1-C6- haloalkylthio, and C1-C6-alkylsulfonyl; R1bis selected from the group consisting of hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, and C3-C8-cycloalkyl; R1cis selected from the group consisting of hydrogen, halogen, cyano, C1-C6-alkyl and C1-C6- haloalkyl; R12is selected from hydrogen or halogen; and 7: C1-C6-alkyl, C1-C6-haloalkyl, and C3-C8-cycloalkyl and R5can be same or different in the C-7 imidazolyl ring. In another preferred embodiment of the present invention, for the compound of formula (I-D-d), wherein R2is hydrogen; R3is selected from the group consisting of hydrogen, chloro and methyl; R4is methyl; R6is selected from the group consisting of hydrogen, chloro or bromo, and methyl; R1ais selected from the group consisting of hydrogen, fluoro, chloro or bromo, cyano, methyl, ethyl, isopropyl, CF3, methoxy, ethoxy or isopropoxy; R1bis selected from the group consisting of hydrogen, fluoro, chloro or bromo, cyano, methyl, and CF3; R1cis selected from the group consisting of hydrogen, fluoro or chloro, and methyl; R12is selected from hydrogen or chloro; and the ring C = selected from one of the following rings C-1 to C-7: wherein R5is methyl, CF3 , and cyclopropyl, and R5can be same or different in the C-7 imidazolyl ring. In yet another preferred embodiment of the present invention, the compound of formula (I) or (I-E) can be selected from a compound of formula (I-E-c), wherein, R2is hydrogen; R3is selected from the group consisting of hydrogen, halogen, and C1-C6-alkyl; R4is selected from C1-C6-alkyl; R1ais selected from the group consisting of halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C3-C8- cycloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C3-C6-cycloalkyloxy, C1-C6-alkylthio, C1-C6- haloalkylthio, and C1-C6-alkylsulfonyl; R1bis selected from the group consisting of hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6-haloalkyl, and C3-C8-cycloalkyl; R1cis selected from the group consisting of hydrogen, halogen, cyano, C1-C6-alkyl and C1-C6- haloalkyl; and 7: C1-C6 -alkyl, C1-C6-haloalkyl, and C3-C8-cycloalkyl and R5can be same or different in the C-7 imidazolyl ring. In yet another preferred embodiment of the present invention, for the compound of formula (I-E-c), wherein, R2is hydrogen; R3is selected from the group consisting of hydrogen, chloro, and methyl; R4is methyl; R1ais selected from the group consisting of hydrogen, fluoro, chloro, bromo, cyano, methyl, ethyl, isopropyl, CF3, methoxy, ethoxy or isopropoxy; R1bis selected from the group consisting of hydrogen, fluoro, chloro, bromo, cyano, methyl, and CF3; R1cis selected from the group consisting of hydrogen, fluoro, chloro, and methyl; the ring C = selected from one of the following rings C-1 to C-7:

[0005] wherein R5is independently selected from the group consisting of hydrogen, halogen, methyl, CF3, and cyclopropyl, and R5can be same or different in the C-7 imidazolyl ring. In one preferred embodiment of the present invention, D in Formula (I) or Formula (I-A) to Formula (I-E) is selected from: D-2 D-1 D-3 D-4 D-5 D-6 D-11 D-12 D-7 D-8 D-9 D-10 D-13 D-14 D-18 D-15 D-16 D-17 D-19 D-20 D-21 D-22 D-23 D-24 In another preferred embodiment, the present invention provided the compound of formula (I-A) to formula (I-E), is particularly described in the below table A: Table A describes the the compounds of formula (I-A) to formula (I- E). Table A: Comp.R1a R1bR1cA.24 3-OCHF2 H H No. A.1 2-F H H A.25 4-OCHF2H H A.2 3-F H H A.26 2-OCF3 H H A.3 4-F H H A.27 3-OCF3H H A.4 2-Cl H H A.28 4-OCF3 H H A.5 3-Cl H H A.29 2-OCH2CF3H H A.6 4-Cl H H A.30 3-OCH2CF3 H H A.7 2-Br H H A.31 4-OCH2CF3H H A.8 3-Br H H A.32 2-SCF3 H H A.9 4-Br H H A.33 3-SCF3H H A.10 4-I H H A.34 4-SCF3 H H A.11 2-CH3H H A.35 2-CN H H A.12 3-CH3 H H A.36 3-CN H H A.13 4-CH3H H A.37 4-CN H H A.14 2-OCH3 H H A.38 3-SO2CH3H H A.15 3-OCH H H A.39 4-SO2CH3 3 H H A.16 4-OCH3 H H A.40 2-Cyclopropyl H H A.17 2-CHF2H H A.41 3-Cyclopropyl H H A.18 3- CHF2 H H A.42 4-Cyclopropyl H H A.19 4- CHF H H A.43 2-N(Me)2 2 H H A.20 2-CF A.44 3-N(Me)2H H 3 H H A.21 3- CF3H H A.45 4-N(Me)2 H H A.22 4- CF H H A.46 2-NO2H H 3 A.23 2-OCHF2H H A.47 3-NO2 H H A.48 4-NO2 H H A.80 3-F 5-F H A.49 2-SMe H H A.81 2-Cl 3-Cl H A.50 3-SMe H H A.82 2-Cl 4-Cl H A.51 4-SMe H H A.83 2-Cl 5-Cl H A.52 3-OCH2(C≡CH) H H A.84 2-Cl 6-Cl HA.533-H H A.85 3-Cl 4-Cl H OCH2(CH=CH2) A.54 4-O-cyclopropyl H H A.86 3-Cl 5-Cl H A.55 4-(C≡C(Me)) H H A.87 2-F 3-Cl H A.56 3-C≡C(CyPr) H H A.88 2-F 4-Cl H A.57 3-NH(COMe) H H A.89 2-F 5-Cl H A.58 4-NH(COCyPr) H H A.90 3-F 4-Cl H A.59 3-NHMe H H A.91 3-F 5-Cl H A.60 4-NH(CyPr) H H A.92 2-Cl 3-F H A.61 3-CONHMe H H A.93 2-Cl 4-F H A.62 4-CON(Me)2 H H A.94 2-Cl 5-F H A.63 3-CONH(CyPr) H H A.95 3-Cl 4-F H A.64 4-CONMe(CyPr) H H A.96 3-Cl 5-Cl H A.65 3-S(O)Me(=NH) H H A.97 3-Cl 5-CF3 HA.663-H H A.98 2-F 4-Br H S(O)Me(=NCyPr) A.99 2-F 5-Br H A.67 3-S(O)Me(=NMe) H H A.100 3-F 4-Br H A.68 4-S(O)Et(=NH) H H A.101 2-Cl 4-Br H A.69 4-S(O)Et(=NMe) H H A.102 2-Cl 5-Br HA.704-H H S(O)Et(=NCyPr) A.103 3-Cl 4-Br H A.71 3-N=S(O)Me2 H H A.104 2-Br 4-F H A.72 3-N=S(O)MeCyPr H H A.105 3-Br 4-F H A.73 4-N=S(O)Me2 H H A.106 2-Br 5-Cl H A.74 4-N=S(O)MeCyPr H H A.107 3-Br 4-Cl H A.75 2-F 3-F H A.108 2-F 3-CH3H A.76 2-F 4-F H A.109 2-F 4-CH3 H A.77 2-F 5-F H A.110 2-F 5-CH3H A.78 2-F 6-F H A.111 2-F 6-CH3 H A.79 3-F 4-F H A.112 2-Cl 3-CH3H A.113 2-Cl 4-Me H A.146 3-CF3 4-Br H A.114 2-CH34-Cl H A.147 3-CF35-Me H A.115 2-F 5-CH3 H A.148 2-Me 4-CF3 H A.116 2-F 6-CH3H A.149 2-Me 5-CF3H A.117 2-Br 5-CH3 H A.150 3-CF3 4-Me H A.118 2-CH33-Br H A.151 3-CF35-CN H A.119 3-CH3 5-Br H A.152 3-CN 4-CF3 H A.120 2-CH3 4-Br H A.153 2-OCHF2 4-Cl H A.121 3-CN 4-F H A.154 2-OCHF24-F H A.122 3-CN 4-Cl H A.155 4-OCF32-Cl H A.123 2-F 5-CN H A.156 S-CF32-Cl H A.124 2-Cl 5-CN H A.157 S-CF3 3-Cl H A.125 2-F 4-CN H A.158 3-CF34-Cl H A.126 2-Cl 4-CN H A.159 4-SCH3 2-F H A.127 3-F 4-CN H A.160 4-SCH32-Cl H A.128 3-Cl 4-CN H A.161 4- SO2CH3 2-F H A.129 3-Cl 5-CN H A.162 4-SO2CH32-Cl H A.130 2-Br 5-CN H A.163 4-SO2CH3 3-F H A.131 2-CN 3-Br H A.164 4-SO2CH33-Cl H A.132 3-CN 5-Br H A.165 3-SO2CH3, 4-F H A.133 2-CN 4-Br H A.166 3-SO2CH34-Cl H A.134 3-Br 4-CN H A.167 5-SO2CH3 2-F H A.135 2-Br 4-CN H A.168 5-SO2CH32-Cl H A.136 2-F 3-CF3 H A.169 2-OCH3 4-Cl H A.137 2-F 4-CF3H A.170 3-OCH32-F H A.138 S-CF3 2-F H A.171 4-OCH3 2-Cl H A.139 3-F 4-CF3H A.172 3-OCH34-Br H A.140 S-CF3 3-F H A.173 5-OCH3 3-Br H A.141 4-F 3-CF3H A.174 2-Cl 4-Cl H A.142 2-Cl 3-CF3 H A.176 2-F 3-F 4-F A.143 2-Cl 4-CF3H A.177 2-F 3-F 5-F A.144 3-CF3 5-Br H A.178 2-F 3-F 6-F A.145 3-CF3 5-CF3 H A.179 3-F 4-F 5-F PI External A.180 2-F 4-F 6-F A.189 4-OMe 3-F 5-F A.181 2-Cl 4-F 5-F A.190 2-Cl 4-Cl 6-Cl A.182 3-Cl 4-F 5-Cl A.191 2-Cl 4-Cl 6-Me A.183 S-CF33-F 4-F A.192 2-O-CF2-O-3 H A.184 4-Me 3-Cl 5-Cl A.193 3-O-CF2-O-4 H A.185 4-Me 3-F 5-F A.194 4-O-CF2-O-5 2-Cl A.186 3-Me 5-Me 4-Cl A.195 2-CH2-CH2-CH2-3 H A.187 3-Me 5-Me 4-F A.195 3-CH2-CH2-CH2-4 H A.188 4-OMe 3-Cl 5-Cl A.196 2-CH2-CH2-CH2-3, 4-F * CyPr =cyclopropyl. The agriculturally acceptable salts of the compounds of formula (I), or formula (I-A) to formula (I-E) encompass especially the salts of those cations or the acid addition salts of those acids whose cations and anions, respectively, have no adverse effect on the fungicidal action of the compounds of formula 5 (I). or formula (I-A) to formula (I-E). The salts obtainable in this way likewise have fungicidal properties. Anions of useful acid addition salts are primarily chloride, bromide, fluoride, hydrogensulfate, sulfate, dihydrogenphosphate, hydrogenphosphate, phosphate, nitrate, bicarbonate, carbonate, hexafluorosilicate, hexafluorophosphate, benzoate, and the anions of C1-C4-alkanoic acids, preferably 10 formate, acetate, propionate and butyrate. They can be formed by reacting a compound of formula (I) or any one of the formula (I-A) to formula (I-E), with an acid of the corresponding anion, preferably of hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, or nitric acid. The compounds of the present invention may be present either in pure form or as mixtures of different possible isomeric forms such as stereoisomers e.g. a racemate, individual stereoisomers, or 15 constitutional isomers or as an optically active form. The various stereoisomers include enantiomers, diastereomers, chiral isomers, atropisomers, conformers, rotamers, tautomers, optical isomers, polymorphs, and geometric isomers. Any desired mixtures of these isomers fall within the scope of the claims of the present disclosure. One skilled in the art will appreciate that one stereoisomer may be more active and / or may exhibit beneficial effects when enriched relative to the other isomer(s) or when 20 separated from the other isomer(s). Additionally, the person skilled in the art knows processes or methods or technologies to separate, enrich, and / or to selectively prepare said isomers. The compounds of formula (I) or formula (I-A) to formula (I-E) can be present in different crystal modifications whose biological activity may differ. They also form part of the subject matter of the PI External present invention. The compounds of formula (I) or formula (I-A) to formula (I-E) can be present in atropisomers arising from restricted rotation about a single bond of asymmetric groups. They also form part of the subject matter of the present invention. The compounds selected from formula (I), or formula (I-A) to formula (I-E) (including all 5 stereoisomers, N-oxides, and salts thereof), may typically exist in more than one form. The compounds of formula (I), or formula (I-A) to formula (I-E) thus include all crystalline and non-crystalline forms of the compound that formula (I), or formula (I-A) to formula (I-E) represents. Non-crystalline forms include embodiments which are solids such as waxes and gums as well as embodiments which are liquids such as solutions and melts. Crystalline forms include embodiments which represent essentially 10 a single crystal type and embodiments which represent a mixture of polymorphs (i.e. different crystalline types). The following schemes illustrate approaches for preparing compounds of formula (I), or formula (I-A) to formula (I-E). The following descriptions and examples are provided for illustrative purposes and 15 should not be construed as limiting in terms of substituents or substitution patterns. Further, the mentioned reagents, solvents and reaction conditions are intended for the purpose of exemplification only and should not be construed as limiting. In one embodiment, the present invention provides a process for the synthesis of compounds of formula (I), or formula (I-A) to formula (I-E). 20 The following schemes illustrate approaches for preparing the compounds of formula (I), or formula (I- A) to formula (I-E). The following descriptions and examples are provided for illustrative purposes and should not be construed as limiting in terms of substituents or substitution patterns. Further, the mentioned reagents, solvents and reaction conditions are intended for the purpose of exemplification only and should not be construed as limiting. 25 The compounds of the present invention as defined by formula (I), or formula (I-A) to formula (I-E) and / or in the table 1 may be prepared, in a known manner, in a variety of ways as described in the schemes 1-6. The definitions of B, R1a-R1c, R2, R3, R4, R9, R10and Z1-Z3in the compounds of formulae (I), (I-A to I-E), are as defined above in the detailed description of the invention unless otherwise stated specifically. 30 Scheme-1: PI External In one of the preferred embodiments, the compounds of general formula (I-A) can be prepared by acid- amine coupling reactions between an amine compound of formula 1 and a compound of general formula 2 wherein X represents -OH or -halo group in the presence or absence of coupling reagents such as 1- 5 propanephosphonic acid cyclic anhydride, hexafluorophosphate azabenzotriazole tetramethyl uronium, N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride, and the like or alkyl chloroformates such as ethyl chloroformate, isobutylchloroformate, etc and a solvent such as dichloromethane, tetrahydrofuran, N,N-dimethyl formamide and the like. These transformations are typically carried out at a temperature in the range of 0 °C to 25 °C. 10 Scheme-2: As shown in scheme 2, the compounds of general formula (I-A) can also be prepared by ester-amine coupling reactions between an amine compound of formula 1 and a compound of general formula 3, 15 wherein R is alkyl or aryl group in the presence or absence of a base such as LiHMDS, KOt-Bu, and the like and in the presence or absence of activating reagents such as Lewis acids. These reactions are carried out in various solvents such as toluene, tetrahydrofuran, methanol and the like. These transformations are typically carried out at a temperature in the range of 0 °C to 120 °C. 20 Scheme-3: PI External According to scheme 3, the compounds represented by general formula (I-A) can also be prepared by metal catalyzed C-N coupling of an amine of formula 4 and aryl halide or pseudo-halide compound of formula 5. The compounds of formula 5 with required substitution pattern can either be purchased from commercial sources or can be prepared using literature protocols. Another requisite coupling partner of 5 general formula 4 can be constructed via acid-amine coupling reaction between an acid or acyl halide of formula 10 and an amine of general formula 1. The C-N coupling reactions are usually carried out in the presence of solvents, while the solvents which can be used for this reaction are not particularly limited as long as they do not adversely affect the reaction. For example, ethers such as 1,4-dioxane, tetrahydrofuran, ethylene glycol, dimethyl ether and10 diethylene glycol dimethyl ether; aromatic hydrocarbons such as benzene, toluene and xylene; N- amides such as N,N-dimethylformamide, N-dimethylacetamide and 1-methyl-2-pyrrolidone; alcohols such as methanol, ethanol, propanol, butanol, 2-propanol and 2-methyl-2-propanol; nitriles such as acetonitrile; or water or a mixture thereof may serve this purpose. Preferable solvents include aromatic hydrocarbons such as toluene and xylene; and ethers such as 1,4-dioxane, tetrahydrofuran; out of which 15 toluene and 1,4-dioxane are the most preferable ones. The C-N coupling reaction is carried out in the presence of a base selected from, but not limited to, metal alkoxides such as sodium methoxide, sodium ethoxide, potassium tert-butoxide, and sodium tert- butoxide; inorganic bases such as sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, cesium carbonate, sodium phosphate, tribasic potassium phosphate, potassium20 hydrogenphosphate, and potassium hydride; organic bases such as triethylamine, N,N- diisopropylethylamine and pyridine. Preferred bases include metal alkoxides such as potassium tert- butoxide, sodium tert-butoxide and inorganic bases such as cesium carbonate and tribasic potassium phosphate. The palladium catalysts that can be used for this C-N coupling reaction include, but are not limited to, 25 inorganic palladium salts such as palladium chloride; organic palladium complexes such as palladium acetate; tetrakis(triphenylphosphine)palladium(0), bis (triphenylphosphine)palladium(II) chloride, 1,1'- bis (diphenylphosphino) phenylpalladium (II) chloride, and tris(dibenzylidene acetone)dipalladium(0). Palladium catalysts such as palladium chloride, palladium acetate, tetrakis (triphenylphosphine) palladium (0), bis (triphenylphosphine) palladium (II) chloride, 1'- bis (diphenylphosphino) 30 phenylpalladium (II) chloride and tris (dibenzylidene acetone) dipalladium (0) are more preferable. The C-N coupling reaction can also be carried out using further ligands in combination with the above- mentioned catalysts for a fruitful transformation. A list of possible ligands for this transformation include, but are not limited to, tris(o-tolyl)phosphine, tricyclohexylphosphine, tri-tert- butylphosphonium tetrafluoroborate, (oxydi-2,1-phenylene)bis[dicyclohexyl] phosphine, 4,5-35 bis(diphenylphosphino)-9,9-dimethylxanthene, 2-dicyclohexylphosphino-2′-(N,N- PI External dimethylamino)biphenyl, 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl, 2- dicyclohexylphosphino-2′,6′-dimethoxybiphenyl, 2-dicyclohexylphosphino-2′,6′- diisopropoxybiphenyl, 2-di-tert-butylphosphino-2′,4′,6′-triisopropylbiphenyl, 2-di-tert- butylphosphino-3,4,5,6-tetramethyl-2′,4′,6′-triisopropyl-1,1′-biphenyl, (2-biphenylyl) di-tert- 5 butylphosphine; 2-(di-tert-butylphosphino)biphenyl, 2-di-tert-butylphosphino-3,4,5,6-tetramethyl- 2′,4′,6′-triisopropyl-1,1′-biphenyl, 1,1′-ferrocenediyl-bis(diphenylphosphine), 2-di-tert- butylphosphino-2′-methylbiphenyl, 2-methyl-2′-dicyclohexylphosphinobiphenyl and [1,1′-biphenyl]- 3-sulfonic acid, 2′-(dicyclohexylphosphino)-2,6-dimethoxy- sodium salt. The preferred ligands include 2-(di-tert-butylphosphino)biphenyl, 2-dicyclohexylphosphino-2′,4′,6′-triisopropylbiphenyl, 2-di-tert-10 butylphosphino-3,4,5,6-tetramethyl-2′,4′,6′-triisopropyl-1,1′-biphenyl (Oxydi-2,1- phenylene)bis[dicyclohexyl] phosphine, 1,1′-ferrocenediyl-bis(diphenylphosphine and 4,5- bis(diphenylphosphino)-9,9-dimethylxanthene. Pre-catalysts can also be utilized for such transformations. A list of possible pre-catalysts include, but are not limited to, (SP-4-3)-[dicyclohexyl[3,6-dimethoxy-15 2′,4′,6′-tris(1-methylethyl)[1,1′-biphenyl]-2-yl]phosphine-κP](methanesulfonato-κO)[2′- (methylamino-κN)[1,1′-biphenyl]-2-yl-κC], [(2-di-cyclohexylphosphino-3,6-dimethoxy-2′,4′,6′- triisopropyl-1,1′-biphenyl)-2-(2′-amino-1,1′ -biphenyl)]palladium(II) methanesulfonate methanesulfonate, [(2-di-tert-butylphosphino-3,6-dimethoxy-2′,4′,6′-triisopropyl-1,1′-biphenyl)-2-(2′- amino-1,1′-biphenyl)]palladium(II) methanesulfonate, [2-(di-1-adamantylphosphino)-2′,4′,6′-20 triisopropyl-3,6-dimethoxybiphenyl][2-(2′-amino-1,1′-biphenyl)]palladium(II) methanesulfonate, [2′- (amino-κN)[1,1′-biphenyl]-2-yl-κC][2′-[(1,1-dimethylethyl)phenylphosphino-κP]-N2, N2, N6, N6- tetramethyl[1,1′-biphenyl]-2,6-diamine](methanesulfonato-κO)palladium, [dicyclohexyl[3-(1- methylethoxy)-2′,4′,6′-tris(1-methylethyl)[1,1′-biphenyl]-2-yl]phosphine-κP](methanesulfonato- κO)[2′-(methylamino-κN)[1,1′-biphenyl]-2-yl-κC] palladium. 25 Halogens, such as, chloro-, bromo-, and iodo-, are the trivial leaving groups (LG) that are used in this transformation. However, it is also possible to use tosylates, mesylates, and triflates, in somewhat similar manner, as leaving groups allowing fruitful transformations. The reactions can be performed at a temperature range of 0-200 °C, preferably at a temperature range of 50-150 °C for a duration of time between 30 minutes to 24 hours. 30 Scheme-4: PI External As shown in scheme 4, the compound denoted by general formula (I-A) can also be synthesized through oxidation of active methylene group (for instance benzylic -CH2-) as present in compound of formula 7 in the presence or absence of metal oxides such as Iron oxide, Manganese oxide, Selenium dioxide etc or in presence of oxygen atmosphere. These types of transformations are typically carried out in 5 solvents such as water, ethyl acetate, acetonitrile, dimethyl sulfoxide and the like at a temperature in the range of such as 25°C to 100 °C. Scheme-5: In one of the preferred embodiments, the compound represented by formula (I-C) can be prepared via 10 acid-amine coupling reaction of an amine of formula 8 and an acid or acyl halide denoted by general formula 2 in the presence of commonly used coupling reagents and conditions. Scheme-6: 15 In another preferred embodiment, the compound represented by formula (I-D-a) can also be prepared via amide coupling reaction of an amine of formula 9 and an acid or acyl halide denoted by general formula 2 under commonly used coupling reaction conditions. Scheme-7: PI External wherein R2, R3, R4, R6and R12are as defined above for the compound of formula (I-D-a) or formula (I-E-a); and X is selected from Cl, Br, I, tosylate (OSO2-p-tolyl), mesylate (OSO2Me) or triflate (OSO2CF3). In another embodiment of the present invention, an amine intermediate compound of formula 15 can 5 be prepared according to scheme-7, wherein a compound of formula 10 is reacted with tosylmesyl isocyanide and a base in one or more solvents to obtain a compound of formula 11. The compound of formula 11 is then treated with a compound of formula 12 or formula 14 and a base preferably lithium based organic base in a solvent to obtain a compound of formula 13. The compound of formula 13 is subjected to nitrile reduction using a combination of a transition metal salt such as cobalt (II) chloride 10 and sodium borohydride in a solvent to obtain the intermediate compound of formula 15. Scheme-8: In another preferred embodiment, the compound represented by formula (I-D-d) or formula (I-E-c) can be prepared via reacting an amine of formula 15 with an acid or acyl halide denoted by general formula15 2A in the presence of an optional coupling reagent and a solvent, wherein R2, R3, R4, ring C and R1a- R1care as described for the compound of formula (I-D-d) / formula (I-E-c) in the description. The compounds of the present disclosure may be applied by a variety of known techniques, either as the compounds themselves or as formulations comprising these compounds. For example, the compounds may be applied to the roots or foliage of plants for the control of various fungi, without 20 damaging the commercial value of the plants. The materials may be applied in the form of any of the generally used formulation types, for example, as solutions, dusts, wettable powders, flowable concentrates, or emulsifiable concentrates. Preferably, the compounds of the present disclosure are applied in the form of a formulation, comprising one or more of the compounds of formula (I), or formula (I-A) to formula (I-E) together with a 25 phytologically acceptable carrier. Concentrated formulations may be dispersed in water, or other liquids, for application, or formulations may be dust-like or granular, which may then be applied without further treatment. The formulations can be prepared according to procedures that are conventional in the agricultural chemical art. PI External The present disclosure contemplates all vehicles by which one or more of the compounds may be formulated for delivery and use as a fungicide. Typically, formulations are applied as aqueous suspensions or emulsions. Such suspensions or emulsions may be produced from water-soluble, water- suspendible, or emulsifiable formulations which are solids, usually known as wettable powders; or 5 liquids, usually known as emulsifiable concentrates, aqueous suspensions, or suspension concentrates. As will be readily appreciated, any material to which these compounds may be added may be used, provided it yields the desired utility without significant interference with the activity of these compounds as antifungal agents. In one embodiment, the present invention provides an agrochemical composition comprising a 10 compound of formula (I), or formula (I-A) to formula (I-E), agriculturally acceptable salts, constitutional isomers, stereo-isomers, diastereoisomers, enantiomers, chiral isomers, atropisomers, conformers, rotamers, tautomers, optical isomers, polymorphs, geometric isomers, or N-oxides thereof, optionally with one or more additional active ingredient(s), and optionally together with an auxiliary such as an inert carrier or any other essential ingredient(s) such as surfactants, additives, solid diluents 15 and liquid diluents. An agrochemical composition comprises a fungicidally effective amount of a compound of formula (I), or formula (I-A) to formula (I-E). The term "effective amount" denotes an amount of the composition or of the compound of formula (I), or formula (I-A) to formula (I-E), which is sufficient for controlling harmful fungi on cultivated plants or in the protection of materials and which does not result in a 20 substantial damage to the treated plants. Such an amount can vary in a broad range and is dependent on various factors, such as the fungal species to be controlled, the treated cultivated plant or material, the climatic conditions and the specific compound of formula (I), or formula (I-A) to formula (I-E) being used. In another embodiment, the present invention provides a composition comprising at least one compound 25 of formula (I), or formula (I-A) to formula (I-E) and seeds. The amount of the compound of formula (I), or formula (I-A) to formula (I-E) in the composition ranges from 0.1 g ai (gram per active ingredient) to 1 kg ai (kilogram per active ingredient) per 100 kg of seeds. The compounds of formula (I), or formula (I-A) to formula (I-E), their N-oxides, isomers, polymophs or the agriculturally acceptable salts thereof can be converted into customary types of agrochemical 30 compositions, e. g. into solutions, emulsions, suspensions, dusts, powders, pastes, granules, pressings, capsules, and mixtures thereof. Examples for such composition types are suspensions (e. g. SC, OD, FS), emulsifiable concentrates (e. g. EC), emulsions (e. g. EW, EO, ES, ME), capsules (e. g. CS, ZC), pastes, pastilles, wettable powders or dusts (e. g. WP, SP, WS, DP, DS), pressings (e. g. BR, TB, DT), granules (e. g. WG, SG, GR, FG, GG, MG), insecticidal articles (e. g. LN), as well as gel formulations 35 for the treatment of plant propagation materials such as seeds (e. g. GF). These and further composition PI External types are defined in the "Catalogue of pesticide Formulation types and international coding system", Technical Monograph No.2, 6thEd. May 2008, CropLife International. The mentioned compositions are prepared in a known manner, such as described by Mollet and Grubemann, “Formulation Technology”, Wiley VCH, Weinheim, 2001; or Knowles, “New 5 Developments in Crop Protection product Formulation”, Agrow Reports DS243, T&F Informa, London, 2005. Examples for suitable auxiliaries for formulations and / or agrochemical compositions according to the invention are solvents, liquid carriers, solid carriers or fillers, surfactants, dispersants, emulsifiers, wetters, adjuvants, solubilizers, penetration enhancers, protective colloids, adhesion agents, thickeners, 10 humectants, repellents, attractants, feeding stimulants, compatibilizers, bactericides, anti-freezing agents, anti-foaming agents, colorants, tackifiers and binders. The agrochemical compositions generally comprise between 0.01 and 95%, preferably between 0.1 and 90%, and in particular between 0.5 and 75%, by weight of active ingredient (ai). The active ingredients (ai) are employed in a purity from 90% to 100%, preferably from 95% to 100% (according to NMR 15 spectrum). For the purposes of treatment of plant propagation materials, particularly seeds, solutions for seed treatment (LS), suspoemulsions (SE), flowable concentrates (FS), powders for dry treatment (DS), water-dispersible powders for slurry treatment (WS), water-soluble powders (SS), emulsions (ES), emulsifiable concentrates (EC), and gels (GF) are usually employed. The compositions in question give, 20 after two-to-tenfold dilution, active substance concentrations from 0.01 to 60% by weight, preferably from 0.1 to 40%, in the ready-to-use preparations. When employed in plant protection, the amounts of active substances applied are, depending on the kind of effect desired, from 0.001 to 2 kg per ha, preferably from 0.005 to 2 kg per ha, more preferably from 0.05 to 1.0 kg per ha, and in particular from 0.1 to 0.5 kg per ha. 25 In the treatment of plant propagation materials such as seeds, e. g. by dusting, coating or drenching seed, the generally required amounts of active substance are ranging from 0.1 to 1000 g, preferably from 1 to 1000 g, more preferably from 1 to 100 g and most preferably from 5 to 100 g, per 100 kg of plant propagation material (preferably seeds). When used in the protection of materials or stored products, the amount of active substance applied 30 depends on the kind of application area and on the desired effect. Amounts customarily applied in the protection of materials are ranging from 0.001 g to 2 kg, preferably from 0.005 g to 1 kg, of active substance per cubic meter of treated material. PI External Various types of oils, wetters, adjuvants, fertilizer, or micronutrients, and further pesticides (e. g. herbicides, insecticides, fungicides, growth regulators, safeners, biopesticides) may be added to the active substances or the compositions comprising them as premix or, if appropriate not until immediately prior to use (tank mix). These agents can be mixed with the composition according to the 5 invention in a weight ratio of 1:100 to 100:1, preferably 1:20 to 20:1. A pesticide is generally a chemical or biological agent (such as pesticidally active ingredient, compound, composition, virus, bacterium, antimicrobial or disinfectant) that through its effect deters, incapacitates, kills or otherwise discourages pests. Target pests can include insects, plant pathogens, weeds, mollusks, birds, mammals, fish, nematodes (roundworms), and microbes that destroy property, 10 cause nuisance, spread disease or are vectors for disease. The term "pesticide" includes also plant growth regulators that alter the expected growth, flowering, or reproduction rate of plants; defoliants that cause leaves or other foliage to drop from a plant, usually to facilitate harvest; desiccants that promote drying of living tissues, such as unwanted plant tops; plant activators that activate plant physiology for defense against certain pests; safeners that reduce unwanted 15 herbicidal action of pesticides on crop plants; and plant growth promoters that affect plant physiology e.g. to increase plant growth, biomass, yield or any other quality parameter of the harvestable goods of a crop plant. The user applies the composition according to the invention usually from a predosage device, a knapsack sprayer, a spray tank, a spray plane, or an irrigation system. Usually, the agrochemical 20 composition is made up with water, buffer, and / or further auxiliaries to the desired application concentration and the ready-to-use spray liquor or the agrochemical composition according to the invention is thus obtained. Usually, 20 to 2000 liters, preferably 50 to 400 liters, of the ready-to-use spray liquor are applied per hectare of agricultural useful area. In one embodiment, the present invention provides a combination comprising the compounds of 25 formula (I), or formula (I-A) to formula (I-E) and at least one further pesticidally active substance selected from the group consisting of fungicides, insecticides, nematicides, acaricides, biopesticides, herbicides, safeners, plant growth regulators, antibiotics, fertilizers and nutrients. The compounds of formula (I), or formula (I-A) to formula (I-E), the combinations and the compositions thereof comprising them in the use as fungicides with other fungicides may result in an expansion of 30 the fungicidal spectrum of activity being obtained or in a prevention of fungicide resistance development. Furthermore, in many cases, extraordinary and unexpected effects are obtained. The present invention also relates to agrochemical combinations comprising at least one compound of formula (I), or formula (I-A) to formula (I-E), and at least one further pesticidally active substance selected from the group of fungicides, insecticides, nematicides, acaricides, biopesticides, herbicides, PI External safeners, plant growth regulators, antibiotics, fertiliers and nutrients. The pesticidally active substances reported in WO2015185485 pages 36-43 and WO2017093019 pages 42-56 can be used in conjunction with the compounds of formula (I), or formula (I-A) to formula (I-E). The active substances referred to as component 2, their preparation and their activity e. g. against 5 harmful fungi is known (cf.: http: / / www.alanwood.net / pesticides / ); these substances are commercially available. The compounds described by IUPAC nomenclature, their preparation and their pesticidal activity are also known in prior art. The present invention furthermore relates to agrochemical mixtures comprising at least one compound of formula (I), or formula (I-A) to formula (I-E) (component 1) and at least one further active substance 10 useful for plant protection. By applying the compounds of formula (I), or formula (I-A) to formula (I-E) together with at least one pesticidally active compound an additional effect can be obtained. This can be obtained by applying the compounds of formula (I), or formula (I-A) to formula (I-E) and at least one further pesticidally active substance simultaneously, either jointly (e. g. as tank-mix) or 15 separately, or in succession, wherein the time interval between the individual applications is selected to ensure that the active substance applied first still occurs at the site of action in a sufficient amount at the time of application of the further pesticidally active substance(s). The order of application is not essential for working of the present invention. When applying the compounds of formula (I), or formula (I-A) to formula (I-E) and a pesticidally active 20 substance sequentially the time between both applications may vary e. g. between 2 hours to 7 days. Also, a broader range is possible ranging from 0.25 hour to 30 days, preferably from 0.5 hour to 14 days, particularly from 1 hour to 7 days or from 1.5 hours to 5 days, even more preferred from 2 hours to 1 day. In the binary mixtures and the composition according to the invention the weight ratio of the component 1) and the component 2) generally depends on the properties of the active components used, 25 usually it is in the range of 1:1000 to 1000:1, often in the range of 1:100 to 100:1, regularly in the range of 1:50 to 50:1, preferably in the range of 1:20 to 20:1, more preferably in the range of 1:10 to 10:1, even more preferably in the range of 1:4 to 4:1 and in particular in the range of 1:2 to 2:1. According to a further embodiment of the binary mixtures and the composition thereof, the weight ratio of the component 1) and the component 2) usually is in the range of 1000:1 to 1:1000, often in the range 30 of 100:1 to 1:100, regularly in the range of 50:1 to 1:50, preferably in the range of 20:1 to 1:20, more preferably in the range of 10:1 to 1:10, even more preferably in the range of 4:1 to 1:4 and in particular in the range of 2:1 to 1:2. In the ternary mixtures, i.e. the composition according to the invention comprising the (component 1 and component 2) and a compound III (component 3), the weight ratio of component 1) and component PI External 2) depend of the properties of the active substances being used. Usually it is in the range of 1:100 to 100:1, regularly in the range of 1:50 to 50:1, preferably in the range of 1:20 to 20:1, more preferably in the range of 1:10 to 10:1 and in particular in the range of 1:4 to 4:1 and 1:2 to 2:1, and the weight ratio of component 1) and component 3) usually is in the range of 1:100 to 100:1, regularly in the range of 5 1:50 to 50:1, preferably in the range of 1:20 to 20:1, more preferably in the range of 1:10 to 10:1 and in particular in the range of 1:4 to 4:1 as well as 1:2 to 2:1. Any further active components are, if desired, added in a ratio of 20:1 to 1:20 to the component 1. These ratios are also suitable for inventive mixtures applied by seed treatment. According to one embodiment, individual components of the composition according to the invention 10 such as parts of a kit or parts of a binary or ternary mixture may be mixed by the user himself in a spray tank or any other kind of vessel used for applications (e. g. seed treater drums, seed pelleting machinery, knapsack sprayer). Further auxiliaries may be added, if appropriate. Consequently, one embodiment of the invention is a kit for preparing a usable pesticidal composition, comprising a) a composition comprising component 1) as defined herein and at least one auxiliary; and 15 b) a composition comprising component 2) as defined herein and at least one auxiliary; and optionally c) a composition comprising at least one auxiliary and optionally a further active component 3) as defined herein. Application of the compounds of formula (I) or formula (I-A) to formula (I-E), the combinations and the compositions thereof can be carried out before or during sowing. Methods for applying the 20 compounds of formula (I), the combinations and the compositions thereof, respectively, are application onto plant propagation material, especially seeds, including dressing, coating, pelleting, dusting, and soaking as well as in-furrow application methods. Preferably, the compounds of formula (I) or formula (I-A) to formula (I-E), the combinations and the compositions thereof, respectively, are applied on to the plant propagation material by a method such 25 that germination is not induced, e. g. by seed dressing, pelleting, coating and dusting. In one embodiment, the present invention provides a method for controlling or preventing infestation of plants by phytopathogenic microorganisms in agricultural crops and / or horticultural crops wherein an effective amount of at least one compound of formula (I) or formula (I-A) to formula (I-E) or the combinations or the composition, is applied to the plants, to parts thereof or to a locus thereof. 30 In another embodiment, the present invention provides a method for controlling or preventing infestation of plants by phytopathogenic microorganisms in agricultural crops and or horticultural crops wherein an effective amount of at least one compound of formula (I) or the combination or the composition, is applied to the seeds of plants. PI External The compounds of formula (I), or formula (I-A) to formula (I-E) and the compositions according to the invention, respectively, are suitable as fungicides. They are distinguished by an outstanding effectiveness against a broad spectrum of phytopathogenic fungi, including soil-borne fungi, which derive especially from the classes of the Plasmodiophoromycetes, Peronosporomycetes (syn. 5 Oomycetes), Chytridiomycetes, Zygomycetes, Ascomycetes, Basidiomycetes and Deuteromycetes (syn. Fungi imperfecti). Some are systemically active and they can be used in crop protection as foliar fungicides, fungicides for seed dressing and soil fungicides. Moreover, they are suitable for controlling harmful fungi, which inter alia occur in wood or roots of plants. The compounds of formula (I), or formula (I-A) to formula (I-E) and the compositions according to the 10 invention are particularly important in the control of a multitude of phytopathogenic fungi on various cultivated plants, such as cereals, e. g. wheat, rye, barley, triticale, oats or rice; beet, e. g. sugar beet or fodder beet; fruits, such as pomes, stone fruits or soft fruits, e. g. apples, pears, plums, peaches, almonds, cherries, strawberries, raspberries, blackberries or gooseberries; leguminous plants, such as lentils, peas, alfalfa or soybeans; oil plants, such as rape, mustard, olives, sunflowers, coconut, cocoa beans, castor 15 oil plants, oil palms, ground nuts or soybeans; cucurbits, such as squashes, cucumber or melons; fiber plants, such as cotton, flax, hemp or jute; citrus fruit, such as oranges, lemons, grapefruits or mandarins; vegetables, such as spinach, lettuce, asparagus, cabbages, carrots, onions, tomatoes, potatoes, cucurbits or paprika; lauraceous plants, such as avocados, cinnamon or camphor; energy and raw material plants, such as corn, soybean, rape, sugar cane or oil palm; corn; tobacco; nuts; coffee; tea; bananas; vines 20 (table grapes, grape juice and grape vines); hop; turf; sweet leaf (also called Stevia); natural rubber plants or ornamental and forestry plants, such as flowers, shrubs, broad-leaved trees or evergreens, e. g. conifers; and on the plant propagation material, such as seeds, and the crop material of these plants. Particularly, the compounds of formula (I), or formula (I-A) to formula (I-E) and the composition according to the invention are important in the control of phytopathogenic fungi on cereals (e. g. wheat, 25 rye, barley, triticale, oats or rice) and soybeans and on the plant propagation material, such as seeds, and the crop material of cereals and soybeans. Preferably, the compounds of formula (I), or formula (I-A) to formula (I-E) and composition thereof, respectively are used for controlling a multitude of fungi on field crops, such as potatoes sugar beets, tobacco, wheat, rye, barley, oats, rice, corn, cotton, soybeans, rape, legumes, sunflowers, coffee or sugar 30 cane; fruits; vines; ornamentals; or vegetables, such as cucumbers, tomatoes, beans or squashes. The term "plant propagation material" is to be understood to denote all the generative or reproductive parts of the plant such as seeds and vegetative plant material such as cuttings and tubers (e. g. potatoes), which can be used for the multiplication of the plant. This includes seeds, roots, fruits, tubers, bulbs, rhizomes, shoots, sprouts, twigs, flowers, and other parts of plants, including seedlings and young 35 plants, which are to be transplanted after germination or after emergence from soil. PI External These young plants may also be protected before transplantation by a total or partial treatment by immersion or pouring. Preferably, treatment of plant propagation materials with the compounds of formula (I), or formula (I- A) to formula (I-E), the combinations and or the compositions thereof, respectively, is used for 5 controlling a multitude of fungi on cereals, such as wheat, rye, barley and oats; on rice, corn, cotton and soybeans. The term "cultivated plants" is to be understood as including plants which have been modified by breeding, mutagenesis or genetic engineering including but not limiting to agricultural biotech products on the market or in development (cf. http: / / cera-gmc.org / , see GM crop database therein). Genetically 10 modified plants are plants, which genetic material has been so modified by recombinant DNA techniques that otherwise cannot readily be obtained by cross breeding under natural circumstances, mutations or natural recombination. Typically, one or more genes have been integrated into the genetic material of a genetically modified plant to improve certain properties of the plant. Such genetic modifications also include but are not limited to targeted post-translational modification of protein(s), 15 oligo-or polypeptides e. g. by glycosylation or polymer additions such as prenylated, acetylated or farnesylated moieties or PEG moieties. Plants that have been modified by breeding, mutagenesis or genetic engineering, e. g. have been rendered tolerant to applications of specific classes of herbicides, such as auxin herbicides such as dicamba or 2,4-D; bleacher herbicides such as hydroxylphenylpyruvate dioxygenase (HPPD) inhibitors or phytoene desaturase (PDS) inhibitors; acetolactate synthase (ALS) 20 inhibitors such as sulfonyl ureas or imidazolinones; enolpyruvylshikimate-3-phosphate synthase (EPSPS) inhibitors, such as glyphosate; glutamine synthetase (GS) inhibitors such as glufosinate; protoporphyrinogen-IX oxidase inhibitors; lipid biosynthesis inhibitors such as acetyl CoA carboxylase (ACCase) inhibitors; or oxynil (i. e. bromoxynil or ioxynil) herbicides as a result of conventional methods of breeding or genetic engineering. Furthermore, plants have been made resistant to multiple 25 classes of herbicides through multiple genetic modifications, such as resistance to both glyphosate and glufosinate or to both glyphosate and a herbicide from another class such as ALS inhibitors, HPPD inhibitors, auxin herbicides, or ACCase inhibitors. These herbicide resistance technologies are e. g. described in Pest Managem. Sci.61, 2005, 246; 61, 2005, 258; 61, 2005, 277; 61, 2005, 269; 61, 2005, 286; 64, 2008, 326; 64, 2008, 332; Weed Sci.57, 2009, 108; Austral. J. Agricult. Res.58, 2007, 708; 30 Science 316, 2007, 1185; and references quoted therein. Several cultivated plants have been rendered tolerant to herbicides by conventional methods of breeding (mutagenesis), e. g. Clearfield®summer rape (Canola, BASF SE, Germany) being tolerant to imidazolinones, e. g. imazamox, or ExpressSun®sunflowers (DuPont, USA) being tolerant to sulfonyl ureas, e. g. tribenuron. Genetic engineering methods have been used to render cultivated plants such as soybean, cotton, corn, beets and 35 rape, tolerant to herbicides such as glyphosate and glufosinate, some of which are commercially available under the trade names RoundupReady®(glyphosate-tolerant, Bayer CropScience), PI External Cultivance®(imidazolinone tolerant, BASF SE, Germany) and LibertyLink®(glufosinate-tolerant, BASF, Germany). Furthermore, plants capable to synthesize one or more insecticidal proteins, especially those known from the bacterial genus (Bacillus), by use of recombinant DNA techniques are within the scope of the 5 present invention. The Bacillus are particularly from Bacillus thuringiensis, such as δ-endotoxins, e. g. CrylA(b), CrylA(c), CrylF, CrylF(a2), CryllA(b), CrylllA, CrylllB(bl) or Cry9c; vegetative insecticidal proteins (VIP), e. g. VIP1, VIP2, VIP3 or VIP3A; insecticidal proteins of bacteria colonizing nematodes, e. g. Photorhabdus spp. or Xenorhabdus spp.; toxins produced by animals, such as scorpion toxins, arachnid toxins, wasp toxins, or other insect-specific neurotoxins; toxins produced by fungi, 10 such Streptomycetes toxins, plant lectins, such as pea or barley lectins; agglutinins; proteinase inhibitors, such as trypsin inhibitors, serine protease inhibitors, patatin, cystatin or papain inhibitors; ribosome-inactivating proteins (RIP), such as ricin, maize-RIP, abrin, luffin, saporin or bryodin; steroid metabolism enzymes, such as 3-hydroxysteroid oxidase, ecdysteroid-IDP-glycosyl-transferase, cholesterol oxidases, ecdysone inhibitors or HMG-CoA-reductase; ion channel blockers, such as 15 blockers of sodium or calcium channels; juvenile hormone esterase; diuretic hormone receptors (helicokinin receptors); stilbene synthase, bibenzyl synthase, chitinases or glucanases. In the context of the present invention these insecticidal proteins or toxins are to be understood expressly also as pre- toxins, hybrid proteins, truncated or otherwise modified proteins. Hybrid proteins are characterized by a new combination of protein domains, (see, e. g. WO02 / 015701). Further examples of such toxins or 20 genetically modified plants capable of synthesizing such toxins are disclosed, e. g., in EP374753, WO93 / 007278, WO95 / 34656, EP427529, EP451878, WO03 / 18810 und WO03 / 52073. The methods for producing such genetically modified plants are generally known to the person skilled in the art and are described, e. g. in the publications mentioned above. These insecticidal proteins contained in the genetically modified plants impart to the plants, producing these proteins, tolerance to harmful pests 25 from all taxonomic groups of arthropods, especially to beetles (Coeloptera), two-winged insects (Diptera), and moths (Lepidoptera) and to nematodes (Nematoda). Genetically modified plants capable to synthesize one or more insecticidal proteins are, e. g., described in the publications mentioned above, and some of which are commercially available such as YieldGard®(corn cultivars producing the CrylAb toxin), YieldGard®Plus (corn cultivars producing CrylAb and Cry3Bb1 toxins), Starlink®(corn 30 cultivars producing the Cry9c toxin), Herculex®RW (corn cultivars producing Cry34Ab1, Cry35Ab1 and the enzyme phosphinothricin-N-acetyltransferase [PAT]); NuCOTN®33B (cotton cultivars producing the CrylAc toxin), Bollgard®I (cotton cultivars producing the Cry1 Ac toxin), Bollgard®II (cotton cultivars producing CrylAc and Cry2Ab2 toxins); VIPCOT®(cotton cultivars producing a VIP- toxin); NewLeaf®(potato cultivars producing the Cry3A toxin); Bt-Xtra®, NatureGard®, KnockOut®, 35 BiteGard®, Protecta®, Bt11 (e. g. Agrisure®CB) and Bt176 from Syngenta Seeds SAS, France, (corn cultivars producing the CrylAb toxin and PAT enyzme), MIR604 from Syngenta Seeds SAS, France PI External (corn cultivars producing a modified version of the Cry3A toxin, c.f. WO 03 / 018810), MON 863 from Monsanto Europe S.A., Belgium (corn cultivars producing the Cry3Bb1 toxin), IPC 531 from Monsanto Europe S.A., Belgium (cotton cultivars producing a modified version of the CrylAc toxin) and 1507 from Pioneer Overseas Corporation, Belgium (corn cultivars producing the Cry1 F toxin and PAT 5 enzyme). Furthermore, plants capable to synthesize one or more proteins to increase the resistance or tolerance of those plants to bacterial, viral or fungal pathogens by the use of recombinant DNA techniques are also within the scope of the present invention. Examples of such proteins are the so-called "pathogenesis-related proteins" (PR proteins, see, e. g. EP392225), plant disease resistance genes (e. g. 10 potato cultivars, which express resistance genes acting against Phytophthora infestans derived from the Mexican wild potato Solanum bulbocastanum) or T4-lysozym (e. g. potato cultivars capable of synthesizing these proteins with increased resistance against bacteria such as Erwinia amylvora). The methods for producing such genetically modified plants are generally known to the person skilled in the art and are described, e. g. in the publications mentioned above. 15 Furthermore, plants capable to synthesize one or more proteins, by use of recombinant DNA techniques, to increase the productivity (e. g. biomass production, grain yield, starch content, oil content or protein content), tolerance to drought, salinity or other growth-limiting environmental factors or tolerance to pests and fungal, bacterial or viral pathogens of those plants are within the scope of the present invention. 20 Furthermore, plants that contain a modified quantity of substances of content or new substances of content, by the use of recombinant DNA techniques, to improve human or animal nutrition, e. g. oil crops that produce health-promoting long-chain omega-3 fatty acids or unsaturated omega-9 fatty acids (e. g. Nexera®rape, DOW Agro Sciences, Canada) are also within the scope of the present invention. Furthermore, plants that contain a modified quantity of substances of content or new substances of 25 content, by the use of recombinant DNA techniques, to improve raw material production, e. g. potatoes that produce increased amounts of amylopectin (e. g. Amflora®potato, BASF SE, Germany) are also within the scope of the present invention. The compounds of formula (I), or formula (I-A) to formula (I-D) may be, for example, effective against fungi and fungal vectors of disease as well as phytopathogenic bacteria and viruses. These fungi and 30 fungal vectors of disease as well as phytopathogenic bacteria and viruses are for example: Absidia corymbifera, Alternaria spp, Aphanomyces spp, Ascochyta spp, Aspergillus spp. including A. flavus, A. fumigatus, A. nidulans, A. niger, A. terms, Aureobasidium spp. including A. pullulans, Blastomyces dermatitidis, Blumeria graminis, Bremia lactucae, Botryosphaeria spp. including B. dothidea, B. obtusa, Botrytis spp. inclusing B. cinerea, Candida spp. including C. albicans, C. glabrata, 35 C. krusei, C. lusitaniae, C. parapsilosis, C. tropicalis, Cephaloascus fragrans, Ceratocystis spp, PI External Cercospora spp. including C. arachidicola, Cercosporidium personatum, Cladosporium spp, Claviceps purpurea, Coccidioides immitis, Cochliobolus spp, Colletotrichum spp. including C. musae, Cryptococcus neoformans, Colletotrichum capsici, Diaporthe spp, Didymella spp, Drechslera spp, Elsinoe spp, Epidermophyton spp, Erwinia amylovora, Erysiphe spp. including E. cichoracearum, 5 Eutypa lata, Fusarium spp. including F. culmorum, F. graminearum, F. langsethiae, F. moniliforme, F. oxysporum, F. proliferatum, F. subglutinans, F. solani, Gaeumannomyces graminis, Gibberella fujikuroi, Gloeodes pomigena, Gloeosporium musarum, Glomerella cingulate, Guignardia bidwellii, Gym nosporangium juniperi-virginianae, Helminthosporium spp, Hemileia spp, Histoplasma spp. including H. capsulatum, Laetisaria fuciformis, Leptographium lindbergi, Leveillula taurica, 10 Lophodermium seditiosum, Microdochium nivale, Microsporum spp, Monilinia spp, Mucor spp, Mycosphaerella spp. including M. graminicola, M. pomi, Oncobasidium theobromaeon, Ophiostoma piceae, Paracoccidioides spp, Penicillium spp. including P. digitatum, P. italicum, Petriellidium spp, Peronosclerospora spp. Including P. maydis, P. philippinensis and P. sorghi, Peronospora spp, Parastagonospora nodorum, Phaeosphaeria nodorum, Phakopsora pachyrhizi, Phellinus igniarus, 15 Phialophora spp, Phoma spp, Phomopsis viticola, Phytophthora spp. including P. infestans, Plasmopara spp. including P. halstedii, P. viticola, Pleospora spp., Podosphaera spp. including P. leucotricha, Polymyxa graminis, Polymyxa betae, Pseudocercosporella herpotrichoides, Pseudomonas spp, Pseudoperonospora spp. including P. cubensis, P. humuli, Pseudopeziza tracheiphila, Puccinia spp. including P. hordei, P. recondita, P. striiformis, P. triticina, Pyrenopeziza spp, Pyrenophora spp, 20 Pyricularia spp. including P. oryzae, Pythium spp. including P. ultimum, Ramularia spp, Rhizoctonia spp, Rhizomucor pusillus, Rhizopus arrhizus, Rhynchosporium spp, Scedosporium spp. including S. apiospermum and S. prolificans, Schizothyrium pomi, Sclerotinia spp, Sclerotium spp, Septoria spp, including S. nodorum, S. tritici, Septoria lycopersici, Sphaerotheca macularis, Sphaerotheca fusca (Sphaerotheca fuliginea), Sporothorix spp, Stagonospora nodorum, Stemphylium spp., Stereum 25 hirsutum, Thanatephorus cucumeris, Thielaviopsis basicola, Tilletia spp, Trichoderma spp., including T. harzianum, T. pseudokoningii, T. viride, Trichophyton spp, Typhula spp, Uncinula necator, Urocystis spp, Ustilago spp, Venturia spp. including V. inaequalis, Verticillium spp., and Xanthomonas spp, Ustilaginales such as Ustilaginoidea virens, Ustilago nuda, Ustilago tritici, Ustilago zeae, Cerotelium fici, Chrysomyxa arctostaphyli, Coleosporium ipomoeae, Hemileia vastatrix, Puccinia arachidis, 30 Puccinia cacabata, Puccinia graminis, Puccinia sorghi, Puccinia striiformis f.sp. Hordei, Puccinia striiformis f.sp. Secalis, Pucciniastrum coryli, or Uredinales such as Cronartium ribicola, Gymnosporangium juniperi-viginianae, Melampsora medusae, Phragmidium mucronatum, Physopella ampelosidis, Tranzschelia discolor and Uromyces viciae-fabae, Cryptococcus spp., Exobasidium vexans, Marasmiellus inoderma, Mycena spp., Sphacelotheca reiliana, Typhula ishikariensis, Urocystis 35 agropyri, ltersonilia perplexans, Corticium invisum, Waitea circinata, Rhizoctonia solani, Thanetephorus cucurmeris, Entyloma dahliae, Entylomella microspora, Neovossia moliniae and PI External Tilletia caries, Blastocladiomycetes, such as Physoderma maydis, Mucoromycetes, such as Choanephora cucurbitarum. Non-limiting examples of pathogens of fungal diseases which can be treated in accordance with the invention include the diseases caused by rust disease pathogens, for example Gymnosporangium 5 species, for example Gymnosporangium sabinae; Hemileia species, for example Hemileia vastatrix; Phakopsora species, for example Phakopsora pachyrhizi or Phakopsora meibomiae; Puccinia species, for example Puccinia recondita, Puccinia graminis oder Puccinia striiformis; Uromyces species, for example Uromyces appendiculatus. In particular, Cronartium ribicola (White pine blister rust); Gymnosporangium juniperi-virginianae (Cedar-apple rust); Hemileia vastatrix (Coffee rust); 10 Phakopsora meibomiae and P. pachyrhizi (Soybean rust); Puccinia coronata (Crown Rust of Oats and Ryegrass); Puccinia graminis (Stem rust of wheat and Kentucky bluegrass, or black rust of cereals); Puccinia hemerocallidis (Daylily rust); Puccinia persistens subsp. triticina (wheat rust or 'brown or red rust'); Puccinia sorghi (rust in corn); Puccinia striiformis ('Yellow rust' in cereals); Uromyces appendiculatus (rust of beans); Uromyces phaseoli (Bean rust); Puccinia melanocephala ('Brown rust' 15 in sugarcane); Puccinia kuehnii ('Orange rust' in sugarcane). The present invention further relates to the use of the compounds of formula (I), the combinations or the compositions thereof for controlling or preventing against phytopathogenic fungi such as Septoria spp., Blumeria spp., Podosphaera spp., Sphaerotheca spp., Uncinula spp., Erysiphe spp., Erysiphe spp., Microsphaera diffusa spp., Botrytis spp., Colletotrichum spp, Alternaria spp., Venturia inaequalis spp., 20 and Monilinia spp. of agricultural crops and or horticultural crops. The present invention further relates to the use of the compounds of formula (I), the combinations or the compositions thereof for controlling or preventing against phytopathogenic fungi such as Septoria spp., Blumeria spp., Podosphaera spp., Sphaerotheca spp., Uncinula spp., Erysiphe spp., Erysiphe spp., Microsphaera diffusa spp., Botrytis spp., Colletotrichum spp, Alternaria spp., Venturia inaequalis spp., 25 and Monilinia spp. in cereals, grapevines, fruits, nuts and vegetables. Plants which can be treated in accordance with the invention include the following: cotton, flax, grapevine, fruits, vegetables, such as Rosaceae sp (for example pome fruits such as apples, pears, apricots, cherries, almonds and peaches), Ribesioidae sp., Juglandaceae sp., Betulaceae sp., Anacardiaceae sp., Fagaceae sp., Moraceae sp., Oleaceae sp., Actinidaceae sp., Lauraceae sp., 30 Musaceae sp. (for example banana trees and plantations), Rubiaceae sp. (for example coffee), Theaceae sp., Sterculiceae sp., Rutaceae sp. (for example lemons, oranges and grapefruit); Vitaceae sp. (for example grapes); Solanaceae sp. (for example tomatoes, peppers), Liliaceae sp., Asteraceae sp. (for example lettuce), Umbelliferae sp., Cruciferae sp., Chenopodiaceae sp., Cucurbitaceae sp. (for example cucumber), Alliaceae sp. (for example leek, onion), Papilionaceae sp. (for example peas); 35 major crop plants, such as Poaceae / Gramineae sp. (for example maize, turf, cereals such as wheat, rye, PI External rice, barley, oats, millet and triticale), Asteraceae sp. (for example sunflower), Brassicaceae sp. (for example white cabbage, red cabbage, broccoli, cauliflower, Brussels sprouts, pak choi, kohlrabi, radishes, and oilseed rape, mustard, horseradish and cress), Fabacae sp. (for example bean, peanuts), Papilionaceae sp. (for example soya bean), Solanaceae sp. (for example potatoes), Chenopodiaceae sp. 5 (for example sugar beet, fodder beet, swiss chard, beetroot); Malvaceae (for example cotton); useful plants and ornamental plants for gardens and wooded areas; and genetically modified varieties of each of these plants. More preference is given to controlling the following diseases of soya beans: Fungal diseases on leaves, stems, pods and seeds caused, for example, by Altemaria leaf spot (Altemaria spec. atrans tenuissima), 10 Anthracnose (Colletotrichum gloeosporoides dematium var. truncatum), brown spot (Septoria glycines ), cercospora leaf spot and blight ( Cercospora kikuchii), choanephora leaf blight (Choanephora infundibulifera trispora (Syn.)), dactuliophora leaf spot (Dactuliophora glycines), downy mildew (Peronospora manshurica), drechslera blight (Drechslera glycini), frogeye leaf spot (Cercospora sojina), leptosphaerulina leaf spot (Leptosphaerulina trifolii), phyllostica leaf spot (Phyllosticta 15 sojaecola), pod and stem blight (Phomopsis sojae), powdery mildew (Microsphaera diffusa), pyrenochaeta leaf spot (Pyrenochaeta glycines), rhizoctonia aerial, foliage, and web blight (Rhizoctonia solani), rust (Phakopsora pachyrhizi, Phakopsora meibomiae), scab (Sphaceloma glycines), stemphylium leaf blight (Stemphylium botryosum), target spot (Corynespora cassiicola). Fungal diseases on roots and the stem base caused, for example, by black root rot (Calonectiia 20 crotalariae), charcoal rot (Macrophomina phaseolina), fusarium blight or wilt, root rot, and pod and collar rot (Fusarium oxysporum, Fusarium orthoceras, Fusarium semitectum, Fusarium equiseti), mycoleptodiscus root rot (Mycoleptodiscus terrestris), neocosmospora (Neocosmospora vasinfecta), pod and stem blight (Diaporthe phaseolorum), stem canker (Diaporthe phaseolorum var. caulivora), phytophthora rot (Phytophthora megasperma), brown stem rot (Phialophora gregata), pythium rot 25 (Pythium aphanidennatum, Pythium irregulare, Pythium debaryanum, Pythium myriotylum, Pythium ultimum), rhizoctonia root rot, stem decay, and damping-off (Rhizoctonia solani), sclerotinia stem decay (Sclerotinia sclerotiorum), sclerotinia southern blight (Sclerotinia rolfsii), thielaviopsis root rot (Thielaviopsis basicola). The present invention also relates to the use of the compounds of formula (I), the combinations or the 30 compositions thereof for controlling or preventing the following plant diseases: Puccinia spp. (rusts) on various plants, for example, but not limited to P. triticina (brown or leaf rust), P. striiformis (stripe or yellow rust), P. hordei (dwarf rust), P. graminis (stem or black rust) or P. recondita (brown or leaf rust) on cereals, such as e. g. wheat, barley or rye and Phakopsoraceae spp. on various plants, in particular Phakopsora pachyrhizi and P. meibomiae (soybean rust) on soybeans, Hemileia PI External vastatrix (Coffee rust), Uromyces appendiculatus, Uromyces fabae and Uromyces phaseoli (rust of beans). The compounds, the combinations and the compositions of the present invention can be used for controlling or preventing plant diseases. The compounds of formula (I), or formula (I-A) to formula (I- 5 E), the combinations and / or the compositions thereof, respectively, are particularly suitable for controlling the following plant diseases: Albugo spp. (white rust) on ornamentals, vegetables (e. g. A. Candida) and sunflowers (e. g. A. tragopogonis); Altemaria spp. (Alternaria leaf spot) on vegetables, rape (A. brassicola or brassicae), sugar beets (A. tenuis), fruits, rice, soybeans, potatoes (e. g. A. solani or A. alternata), tomatoes (e. g. 10 A. solani or A. alternata) and wheat; Aphanomyces spp. on sugar beets and vegetables; Ascochyta spp. on cereals and vegetables, e. g. A. tritici (anthracnose) on wheat and A. hordei on barley; Bipolaris and Drechslera spp. (teleomorph: Cochliobolus spp.), e. g. Southern leaf blight (D. maydis) or Northern leaf blight (B. zeicola) on corn, e. g. spot blotch (C. sorokiniana) on cereals and e. g. B. oryzae on rice and turfs; Blumeria (formerly Erysiphe) graminis (powdery mildew) on cereals (e. g. on wheat or 15 barley); Botrytis cinerea (teleomorph: Botryotinia fuckeliana: grey mold) on fruits and berries (e. g. strawberries), vegetables (e. g. lettuce, carrots, celery and cabbages), rape, flowers, vines, forestry plants and wheat; Bremia lactucae (downy mildew) on lettuce; Ceratocystis (syn. Ophiostoma) spp. (rot or wilt) on broad-leaved trees and evergreens, e. g. C. ulmi (Dutch elm disease) on elms; Cercospora spp. (Cercospora leaf spots) on corn (e. g. Gray leaf spot: C. zeae-maydis), rice, sugar beets (e. g. C. 20 beticola), sugar cane, vegetables, coffee, soybeans (e. g. C. sojina or C. kikuchii) and rice; Cladosporium spp. on tomatoes (e. g. C. fulvum: leaf mold) and cereals, e. g. C. herbarum (black ear) on wheat; Claviceps purpurea (ergot) on cereals; Cochliobolus (anamorph: Helminthosporium of Bipolaris) spp. (leaf spots) on corn (C. carbonum), cereals (e. g. C. sativus, anamorph: B. sorokiniana) and rice (e. g. C. miyabeanus, anamorph: H. oryzae); Colletotrichum (teleomorph: Glomerella) spp. 25 (anthracnose) on cotton (e. g. C. gossypii), corn (e. g. C. graminicola: Anthracnose stalk rot), soft fruits, potatoes (e. g. C. coccodes: black dot), beans (e. g. C. lindemuthianum) and soybeans (e. g. C. truncatum or C. gloeosporioides); Corticium spp., e. g. C. sasakii (sheath blight) on rice; Corynespora cassiicola (leaf spots) on soybeans and ornamentals; Cycloconium spp., e. g. C. oleaginum on olive trees; Cylindrocarpon spp. (e. g. fruit tree canker or young vine decline, teleomorph: Nectria or Neonectria 30 spp.) on fruit trees, vines (e. g. C. liriodendri, teleomorph: Neonectria liriodendri: Black Foot Disease) and ornamentals; Dematophora (teleomorph: Rosellinia) necatrix (root and stem rot) on soybeans; Diaporthe spp., e. g. D. phaseolorum (damping off) on soybeans; Drechslera (syn. Helminthosporium, teleomorph: Pyrenophora) spp. on corn, cereals, such as barley (e. g. D. teres, net blotch) and wheat (e. g. D. tritici-repentis: tan spot), rice and turf; Esca (dieback, apoplexy) on vines, caused by Formitiporia 35 (syn. Phellinus) punctata, F. mediterranea, Phaeomoniella chlamydospora (earlier Phaeoacremonium chlamydosporum), Phaeoacremonium aleophilum and / or Botryosphaeria obtusa; Elsinoe spp. on pome PI External fruits (E. pyri), soft fruits (E. veneta: anthracnose) and vines (E. ampelina: anthracnose); Entyloma oryzae (leaf smut) on rice; Epicoccum spp. (black mold) on wheat; Erysiphe spp. (powdery mildew) on sugar beets (£. betae), vegetables (e. g. E. pisi), such as cucurbits (e. g. E. cichoracearum), cabbages, rape (e. g. E. cruciferarum); Eutypa lata (Eutypa canker or dieback, anamorph: Cytosporina lata, syn. 5 Libertella blepharis) on fruit trees, vines and ornamental woods; Exserohilum (syn. Helminthosporium) spp. on corn (e. g. E. turcicum); Fusarium (teleomorph: Gibberella) spp. (wilt, root or stem rot) on various plants, such as F. graminearum or F. culmorum (root rot, scab or head blight) on cereals (e. g. wheat or barley), F. oxysporum on tomatoes, F. solani (f. sp. glycines now syn. F. virguliforme) and F. tucumaniae and F. brasiliense each causing sudden death syndrome on soybeans, and F. verticillioides 10 on corn; Gaeumannomyces graminis (take-all) on cereals (e. g. wheat or barley) and corn; Gibberella spp. on cereals (e. g. G. zeae) and rice (e. g. G. fujikuroi: Bakanae disease); Glomerella cingulata on vines, pome fruits and other plants and G. gossypii on cotton; Grainstaining complex on rice; Guignardia bidwellii (black rot) on vines; Gymnosporangium spp. on rosaceous plants and junipers, e. g. G. sabinae (rust) on pears; Helminthosporium spp. (syn. Drechslera, teleomorph: Cochliobolus) on 15 corn, cereals and rice; Hemileia spp., e. g. H. vastatrix (coffee leaf rust) on coffee; Isariopsis clavispora (syn. Cladosporium vitis) on vines; Macrophomina phaseolina (syn. phaseoli) (root and stem rot) on soybeans and cotton; Microdochium (syn. Fusarium) nivale (pink snow mold) on cereals (e. g. wheat or barley); Microsphaera diffusa (powdery mildew) on soybeans; Monilinia spp., e. g. M. laxa, M. fructicola and M. fructigena (bloom and twig blight, brown rot) on stone fruits and other rosaceous 20 plants; Mycosphaerella spp. on cereals, bananas, soft fruits and ground nuts, such as e. g. M. graminicola (anamorph: Septoria tritici, Septoria blotch) on wheat or M. fijiensis (black Sigatoka disease) on bananas; Peronospora spp. (downy mildew) on cabbage (e. g. P. brassicae), rape (e. g. P. parasitica), onions (e. g. P. destructor), tobacco (P. tabacina) and soybeans (e. g. P. manshurica); Phakopsora pachyrhizi and P. meibomiae (soybean rust) on soybeans; Phialophora spp. e. g. on vines 25 (e. g. P. tracheiphila and P. tetraspora) and soybeans (e. g. P. gregata: stem rot); Phoma lingam (root and stem rot) on rape and cabbage and P. betae (root rot, leaf spot and damping-off) on sugar beets; Phomopsis spp. on sunflowers, vines (e. g. P. viticola: can and leaf spot) and soybeans (e. g. stem rot: P. phaseoli, teleomorph: Diaporthe phaseolorum); Physoderma maydis (brown spots) on corn; Phytophthora spp. (wilt, root, leaf, fruit and stem root) on various plants, such as paprika and cucurbits 30 (e. g. P. capsici), soybeans (e. g. P. megasperma, syn. P. sojae), soybeans, potatoes and tomatoes (e. g. P. infestans: late blight) and broad-leaved trees (e. g. P. ramorum: sudden oak death); Plasmodiophora brassicae (club root) on cabbage, rape, radish and other plants; Plasmopara spp., e. g. P. viticola (grapevine downy mildew) on vines and P. halstedii on sunflowers; Podosphaera spp. (powdery mildew) on rosaceous plants, hop, pome and soft fruits, e. g. P. leucotricha on apples; Polymyxa spp., 35 e. g. on cereals, such as barley and wheat (P. graminis) and sugar beets (P. betae) and thereby transmitted viral diseases; Pseudocercosporella herpotrichoides (eyespot, teleomorph: Tapesia yallundae) on cereals, e. g. wheat or barley; Pseudoperonospora (downy mildew) on various plants, e. PI External g. P. cubensis on cucurbits or P. humili on hop; Pseudopezicula tracheiphila (red fire disease or .rotbrenner', anamorph: Phialophora) on vines; Puccinia spp. (rusts) on various plants, e. g. P. triticina (brown or leaf rust), P. striiformis (stripe or yellow rust), P. hordei (dwarf rust), P. graminis (stem or black rust) or P. recondita (brown or leaf rust) on cereals, such as e. g. wheat, barley or rye, P. kuehnii 5 (orange rust) on sugar cane and P. asparagi on asparagus; Pyrenophora (anamorph: Drechslera) tritici- repentis (tan spot) on wheat or P. teres (net blotch) on barley; Pyricularia spp., e. g. P. oryzae (teleomorph: Magnaporthe grisea, rice blast) on rice and P. grisea on turf and cereals; Pythium spp. (damping-off) on turf, rice, corn, wheat, cotton, rape, sunflowers, soybeans, sugar beets, vegetables and various other plants (e. g. P. ultimum or P. aphanidermatum); Ramularia spp., e. g. R. collo-cygni 10 (Ramularia leaf spots, Physiological leaf spots) on barley and R. beticola on sugar beets; Rhizoctonia spp. on cotton, rice, potatoes, turf, corn, rape, potatoes, sugar beets, vegetables and various other plants, e. g. R. solani (root and stem rot) on soybeans, R. solani (sheath blight) on rice or R. cerealis (Rhizoctonia spring blight) on wheat or barley; Rhizopus stolonifer (black mold, soft rot) on strawberries, carrots, cabbage, vines and tomatoes; Rhynchosporium secalis (scald) on barley, rye and 15 triticale; Sarocladium oryzae and S. attenuatum (sheath rot) on rice; Sclerotinia spp. (stem rot or white mold) on vegetables and field crops, such as rape, sunflowers (e. g. S. sclerotiorum) and soybeans (e. g. S. rolfsii or S. sclerotiorum); Septoria spp. on various plants, e. g. S. glycines (brown spot) on soybeans, S. tritici (Septoria blotch) on wheat and S. (syn. Stagonospora) nodorum (Stagonospora blotch) on cereals; Uncinula (syn. Erysiphe) necator (powdery mildew, anamorph: Oidium tuckeri) on 20 vines; Setospaeria spp. (leaf blight) on corn (e. g. S. turcicum, syn. Helminthosporium turcicum) and turf; Sphacelotheca spp. (smut) on corn, (e. g. S. reiliana: head smut), sorghum und sugar cane; Sphaerotheca fuliginea (powdery mildew) on cucurbits; Spongospora subterranea (powdery scab) on potatoes and thereby transmitted viral diseases; Stagonospora spp. on cereals, e. g. S. nodorum (Stagonospora blotch, teleomorph: Leptosphaeria [syn. Phaeosphaeria] nodorum) on wheat; 25 Synchytrium endobioticum on potatoes (potato wart disease); Taphrina spp., e. g. T. deformans (leaf curl disease) on peaches and T. pruni (plum pocket) on plums; Thielaviopsis spp. (black root rot) on tobacco, pome fruits, vegetables, soybeans and cotton, e. g. T. basicola (syn. Chalara elegans); Tilletia spp. (common bunt or stinking smut) on cereals, such as e. g. T. tritici (syn. T. caries, wheat bunt) and T. controversa (dwarf bunt) on wheat; Typhula incarnata (grey snow mold) on barley or wheat; 30 Urocystis spp., e. g. U. occulta (stem smut) on rye; Uromyces spp. (rust) on vegetables, such as beans (e. g. U. appendiculatus, syn. U. phaseoli) and sugar beets (e. g. U. betae); Ustilago spp. (loose smut) on cereals (e. g. U. nuda and U. avaenae), corn (e. g. U. maydis: corn smut) and sugar cane; Venturia spp. (scab) on apples (e. g. V. inaequalis) and pears; and Verticillium spp. (wilt) on various plants, such as fruits and ornamentals, vines, soft fruits, vegetables and field crops, e. g. V. dahliae on strawberries, 35 rape, potatoes and tomatoes. PI External In one embodiment, the compounds of formula (I) or formula (I-A) to formula (I-E) have broad ranges of activity against fungal pathogens. Exemplary pathogens may include, but are not limited to, causing agent of wheat leaf blotch (Zymoseptoria tritici), wheat brown rust (Puccinia triticina), wheat stripe rust (Puccinia striiformis), scab of apple (Venturia inaequalis), powdery mildew of grapevine 5 (Uncinula necator), barley scald (Rhynchosporium secalis), blast of rice (Pyricularia oryzae), rust of soybean (Phakopsora pachyrhizi), glume blotch of wheat (Leptosphaeria nodorum), powdery mildew of wheat (Blumeria graminis f. sp. tritici), powdery mildew of barley (Blumeria graminis f. sp. hordei), powdery mildew of cucurbits (Erysiphe cichoracearum), anthracnose of cucurbits (Colletotrichum lagenarium), leaf spot of beet (Cercospora beticola), early blight of tomato (Alternaria solani), and 10 spot blotch of barley (Cochliobolus sativus). The exact amount of the active material to be applied is dependent not only on the specific active material being applied, but also on the particular action desired, the fungal species to be controlled, and the stage of growth thereof, as well as the parts of the plant or other products to be contacted with the compound. Thus, all the compounds, and formulations containing the same, may not be equally 15 effective at similar concentrations or against the same fungal species. The compound of formula (I), or formula (I-A) to formula (I-E), the combinations and the compositions thereof, respectively, are also suitable for controlling harmful fungi in the protection of stored products or harvest and in the protection of materials. The term "protection of materials" is to be understood to denote the protection of technical and non-living materials, such as adhesives, glues, wood, paper and 20 paperboard, textiles, leather, paint dispersions, plastics, cooling lubricants, fibre or fabrics, against the infestation and destruction by harmful microorganisms, such as fungi and bacteria. As to the protection of wood and other materials, the particular attention is paid to the following harmful fungi: Ascomycetes such as Ophiostoma spp., Ceratocystis spp., Aureobasidium pullulans, Sclerophoma spp., Chaetomium spp., Humicola spp., Petriella spp., Trichurus spp.; Basidiomycetes 25 such as Coniophora spp., Coriolus spp., Gloeophyllum spp., Lentinus spp., Pleurotus spp., Pora spp., Serpula spp. and Tyromyces spp., Deuteromycetes such as Aspergillus spp., Cladosporium spp., Penicillium spp., Trichoderma spp., Altemaria spp., Paecilomyces spp. and Zygomycetes such as Mucor spp., and in addition in the protection of stored products and harvest the following yeast fungi are worthy of note: Candida spp. and Saccharomyces cerevisae. 30 In one embodiment, the present invention provides a method for controlling or preventing phytopathogenic fungi. The method comprises treating the fungi or the materials, plants, plant parts, locus thereof, soil or seeds to be protected against fungal attack, with an effective amount of at least one compound of formula (I), or formula (I-A) to formula (I-E), or a combination or a composition comprising at least one compound of formula (I), or formula (I-A) to formula (I-E). PI External The method of treatment according to the invention can also be used in the field of protecting stored products or harvest against attack of fungi and microorganisms. According to the present invention, the term "stored products" is understood to denote natural substances of plant or animal origin and their processed forms, which have been taken from the natural life cycle and for which long-term protection 5 is desired. Stored products of crop plant origin, such as plants or parts thereof, for example stalks, leafs, tubers, seeds, fruits or grains, can be protected in the freshly harvested state or in processed form, such as pre-dried, moistened, comminuted, ground, pressed or roasted, which process is also known as post- harvest treatment. Also falling under the definition of stored products is timber, whether in the form of crude timber, such as construction timber, electricity pylons and barriers, or in the form of finished 10 articles, such as furniture or objects made from wood. Stored products of animal origin are hides, leather, furs, hairs and the like. The combinations according to the present invention can prevent disadvantageous effects such as decay, discoloration or mold. Preferably "stored products" is understood to denote natural substances of plant origin and their processed forms, more preferably fruits and their processed forms, such as pomes, stone fruits, soft fruits and citrus fruits and their processed 15 forms. It is also possible to use the compounds of formula (I), or formula (I-A) to formula (I-D) as a fungicide. The term “fungicide” as used herein means a compound that controls, modifies, or prevents the growth of fungi. The compounds of formula (I), or formula (I-A) to formula (I-E), the combinations and the compositions 20 thereof, respectively, may be used for improving the health of a plant. The invention also relates to a method for improving plant health by treating a plant, its propagation material and / or the locus where the plant is growing or is to grow with an effective amount of compound of formula (I), or formula (I- A) to formula (I-E) and the composition thereof, respectively. The term "plant health" is to be understood to denote a condition of the plant and / or its products which 25 is determined by several indicators alone or in combination with each other such as yield (e. g. increased biomass and / or increased content of valuable ingredients), plant vigor (e. g. improved plant growth and / or greener leaves ("greening effect")), quality (e. g. improved content or composition of certain ingredients) and tolerance to abiotic and / or biotic stress. The above identified indicators for the health condition of a plant may be interdependent or may result from each other. 30 The compounds of formula (I), or formula (I-A) to formula (I-E) are employed as such or in the form of a composition for treating the fungi or the plants, plant propagation materials, such as seeds, soil, surfaces, materials or rooms to be protected from fungal attack with a fungicidally effective amount of the active substances. The application can be carried out both before and after the infection of the plants, plant propagation materials, such as seeds, soil, surfaces, materials, or rooms by the fungi. PI External Plant propagation material may be treated with the compounds of formula (I), the combinations and the compositions thereof protectively either at or before planting or transplanting. The compounds of the invention can be used in combination with models e.g. embedded in computer programs for site specific crop management, satellite farming, precision farming or precision 5 agriculture. Such models support the site specific management of agricultural sites with data from various sources such as soils, weather, crops (e.g. type, growth stage, plant health), weeds (e.g. type, growth stage), diseases, pests, nutrients, water, moisture, biomass, satellite data, yield etc. with the purpose to optimize profitability, sustainability and protection of the environment. In particular, such models can help to optimize agronomical decisions, control the precision of pesticide applications and 10 record the work performed. As an example, the compounds of the invention can be applied to a crop plant according to an appropriate dose regime if a model models the development of a pest and calculates that a threshold has been reached for which it is recommendable to apply the compound of the invention to the crop plant. Commercially available systems which include agronomic models are e.g. FieldScriptsTM from The 15 Climate Corporation, XarvioTM from BASF, AGLogicTM from John Deere, etc. The compounds of the invention can also be used in combination with smart spraying equipment such as e.g. spot spraying or precision spraying equipment attached to or housed within a farm vehicle such as a tractor, robot, helicopter, airplane, unmanned aerial vehicle (UAV) such as a drone, etc. Such an equipment usually includes input sensors (such as e.g. a camera) and a processing unit configured to 20 analyze the input data and configured to provide a decision based on the analysis of the input data to apply the compound of the invention to the crop plants (respectively the weeds) in a specific and precise manner. The use of such smart spraying equipment usually also requires positions systems (e.g. GPS receivers) to localize recorded data and to guide or to control farm vehicles; geographic information systems (GIS) to represent the information on intelligible maps, and appropriate farm vehicles to 25 perform the required farm action such as the spraying. In an example, pests can be detected from imagery acquired by a camera. In an example the pests can be identified and / or classified based on that imagery. Such identification and / classification can make use of image processing algorithms. Such image processing algorithms can utilize machine learning algorithms, such as trained neutral networks, decision trees and utilize artificial intelligence algorithms. 30 In this manner, the compounds described herein can be applied only where needed. Any range or desired value given herein may be extended or altered without losing the effects sought, as is apparent to the skilled person for an understanding of the teachings herein. The invention disclosed in the present disclosure shall now be elaborated with the help of non-limiting examples. PI External CHEMISTRY EXAMPLES: Experimental Procedure: The acid intermediates such as 1-(2,4-difluorophenyl)-1H-1,2,3-triazole-4-carboxylic acid, and 2-(2,4- difluorophenyl)-2H-1,2,3-triazole-4-carboxylic acid are prepared according to the procedure reported 5 in WO2018019929Al and WO2021094434A1 respectively. The amine compounds such as 2-(4- chlorothiazol-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propan-1-amine and 2-(1-methyl-1H-pyrazol-4-yl)- 2-(4-methylthiazol-2-yl)propan-1-amine are prepared according to the procedure described in scheme- 7 using 2,4-dichlorothiazole and Example 5 respectively. All other starting materials, reagents and solvents are purchased from commercial sources. 10 Example 1: Synthesis of 1-(2,4-difluorophenyl)-1H-1,2,3-triazole-4-carboxylic acid Step 1: Synthesis of ethyl 1-(2,4-difluorophenyl)-1H-1,2,3-triazole-4-carboxylate A solution of 1-azido-2,4-difluorobenzene (2 g, 12.9 mmol) and ethyl propiolate (1.9 g, 19.3 mmol) in tetrahydrofuran (20 mL) was treated with Copper (I) iodide (0.25 g, 1.3 mmol) at 25 °C, and stirred for 12 h. After the completion of the reaction, the reaction mixture was poured into ice water and the15 precipitated solid product was separated by filtration to obtain ethyl 1-(2,4-difluorophenyl)-1H-1,2,3- triazole-4-carboxylate (2.1 g, 8.3 mmol, 64% yield) as an off-white solid. Step 2: Synthesis of 1-(2,4-difluorophenyl)-1H-1,2,3-triazole-4-carboxylic acid A solution of ethyl 1-(2,4-difluorophenyl)-1H-1,2,3-triazole-4-carboxylate (3 g, 11.8 mmol) in tetrahydrofuran (21 mL) and water (9 mL) was treated with lithium hydroxide monohydrate (1.5 g, 35.5 20 mmol) at 25°C, and stirred for 3h. After the completion of the reaction, tetrahydrofuran was evaporated under reduced pressure and pH of the residual material was adjusted to 5 - 6 with 10% aqueous hydrochloric acid. The precipitated solid product was separated by filtration and dried under reduced pressure to obtain 1-(2,4-difluorophenyl)-1H-1,2,3-triazole-4-carboxylic acid (2.5 g, 11.1 mmol, 94% yield) as an off-white solid. 25 Example 2: Synthesis of 1-(2,4-difluorophenyl)-1H-pyrazole-4-carboxylic acid Step 1: Synthesis of ethyl 1-(2,4-difluorophenyl)-1H-pyrazole-4-carboxylate A solution of (2,4-difluorophenyl) hydrazine hydrochloride (1 g, 5.54 mmol) in ethanol (20 mL) was treated with ethyl 2-formyl-3-oxopropanoate (1.04 g, 7.2 mmol) and sodium acetate (0.45 g, 5.54 mmol) at 25 °C, stirred for 30 minutes, heated to 80 °C, and then stirred for 3 h at the same temperature. After 30 the completion of the reaction, ethanol was removed under reduced pressure. The residue obtained was diluted with water (50 mL) and extracted with ethyl acetate (3 x 50 mL). The combined organic extracts were dried over anhydrous sodium sulphate and evaporated under reduced pressure to isolate a crude PI External material which was then purified by CombiFlash® chromatography on silica gel (0-10% ethyl acetate in hexane) to obtain ethyl 1-(2,4-difluorophenyl)-1H-pyrazole-4-carboxylate (1 g, 3.96 mmol, 72% yield) as a yellow solid. Step 2: Synthesis of 1-(2,4-difluorophenyl)-1H-pyrazole-4-carboxylic acid 5 A solution of ethyl 1-(2,4-difluorophenyl)-1H-pyrazole-4-carboxylate (1 g, 3.96 mmol) in tetrahydrofuran (10 mL) and water (5 mL) was treated with lithium hydroxide monohydrate (0.25 g, 5.95 mmol) at 25 °C, and stirred for 18 h. After the completion of the reaction, the volatiles were evaporated under reduced pressure and the residue was acidified with 10% aqueous hydrochloric acid. The precipitated solid product was filtered off and dried under reduced pressure to obtain 1-(2,4- 10 difluorophenyl)-1H-pyrazole-4-carboxylic acid (600 mg, 2.68 mmol, 67% yield) as an off white solid. Example 3: Synthesis of 2-(2,4-difluorophenyl)-2H-1,2,3-triazole-4-carboxylic acid Step 1: Synthesis of ethyl (E)-2-(2-(2,4-difluorophenyl)hydrazineylidene)-3-oxopropanoate A solution of 2,4-difluoroaniline (7.9 mL, 77 mmol) in water (100 mL) and 12M hydrochloric acid (20 15 mL) was treated slowly with a solution of sodium nitrite (5.34 g, 77 mmol) in water (50 mL) at 0 °C. After stirring for 5 minutes at the same temperature, this solution was added dropwise into a solution of ethyl (E)-3-(dimethylamino)acrylate (12.2 g, 85 mmol) and potassium acetate (11.4 g, 116 mmol) in ethanol (150 mL) at 0 °C. The resulting reaction mixture was warmed up to 25 °C and stirred for 10 minutes. After the completion of the reaction, the reaction mixture was diluted with ethyl acetate (400 20 mL), washed with water (150 mL) and with saturated brine solution (100 mL). The combined organic layers were dried over anhydrous sodium sulfate, filtered and evaporated under reduced pressure to obtain the crude ethyl (E)-2-(2-(2,4-difluorophenyl)hydrazineylidene)-3-oxopropanoate (18.92 g, 73.8 mmol, 95% yield). Step 2: Synthesis of ethyl (2E)-2-(2-(2,4-difluorophenyl)hydrazineylidene)-3-(hydroxyimino) 25 propanoate PI External A solution of ethyl (E)-2-(2-(2,4-difluorophenyl)hydrazineylidene)-3-oxopropanoate (18 g, 70 mmol) in ethanol (150 mL) was treated with hydroxylamine hydrochloride (5.86 g, 84 mmol) and potassium acetate (17.24 g, 176 mmol) at 25 °C. The resulting reaction mixture was heated to 80 °C, and stirred for 30 min. After the completion of the reaction, the reaction mixture was diluted with ethyl acetate 5 (500 mL), washed with water (150 mL) and saturated brine solution (100 mL). The separated organic layer was dried over anhydrous sodium sulphate, filtered and evaporated to obtain the crude ethyl (2E)- 2-(2-(2,4-difluorophenyl)hydrazineylidene)-3-(hydroxyimino)propanoate (16 g, 59 mmol, 84% yield). Step 3: Synthesis of ethyl 2-(2,4-difluorophenyl)-2H-1,2,3-triazole-4-carboxylate A solution of ethyl (2E)-2-(2-(2,4-difluorophenyl)hydrazineylidene)-3-(hydroxyimino) propanoate (1 10 g, 3.69 mmol) in acetic anhydride (10 mL) was heated at 140 °C and stirred for 30 minutes. After the completion of the reaction, the reaction mixture was cooled to 25 °C and diluted with water (50 mL). The resulting dark solution was extracted with ethyl acetate (3 x 30 mL). The combined organic layers were dried over anhydrous sodium sulphate and evaporated under reduced pressure to isolate a crude material which was then purified by CombiFlash® chromatography on silica gel (0-20% ethyl acetate 15 in hexane) to obtain ethyl 2-(2,4-difluorophenyl)-2H-1,2,3-triazole-4-carboxylate (0.7 g, 2.76 mmol, 75% yield). Step 4: Synthesis of 2-(2,4-difluorophenyl)-2H-1,2,3-triazole-4-carboxylic acid A solution of ethyl 2-(2,4-difluorophenyl)-2H-1,2,3-triazole-4-carboxylate (9 g, 35.5 mmol) in tetrahydrofuran (100 mL) and water (10 mL) was treated with lithium hydroxide (1.49 g, 35.5 mmol) 20 at 25 °C, and stirred for 2 h. After the completion of the reaction, tetrahydrofuran was evaporated under reduced pressure, and the residue was acidified with 1M aqueous hydrochloric acid to adjust pH 2. The precipitated solid product was filtered, washed with hexane (50 mL) and dried under reduced pressure to afford 2-(2,4-difluorophenyl)-2H-1,2,3-triazole-4-carboxylic acid (6 g, 26.6 mmol, 75% yield) as an off white solid. 25 Example 4: Synthesis of 2-(2,4-difluorophenyl)-2H-tetrazole-5-carboxylic acid Step 1: Synthesis of ethyl 2-(2,4-difluorophenyl)-2H-tetrazole-5-carboxylate A solution of 2,4-difluoroaniline (1 g, 7.75 mmol) in a 1:1 mixture of ethanol and water (10 mL) was treated slowly with 12M hydrochloric acid (4.6 mL, 56 mmol) and sodium nitrite (0.59 g, 8.52 mmol) 30 at 0 °C, and stirred for 30 minutes to obtain the corresponding diazonium salt solution. In another PI External reaction flask, a solution of ethyl 2-oxoacetate (2.45 g, 24 mmol) in ethanol (5 mL) was treated with 4- methylbenzenesulfonohydrazide (1.44 g, 7.75 mmol) at 0 °C. The resulting reaction mixture was warmed up to 25 °C, and stirred for 30 minutes. The reaction mixture was evaporated under reduced pressure to remove ethanol. The resulting residual material was dissolved in pyridine (30 mL), cooled 5 to 0 °C. To this cold reaction mixture, the diazonium salt solution (prepared above) was added slowly. The reaction mixture was warmed to 25 °C and stirred for 3 h. After the completion of the reaction, the reaction mixture was diluted with water (60 mL) and extracted with ethyl acetate (2 x 50 mL). The combined organic extracts were washed with saturated brine solution (30 mL), dried over anhydrous sodium sulphate and evaporated under reduced pressure. The residual material thus obtained was 10 purified by CombiFlash® chromatography on silica gel (0-10% ethyl acetate in hexane) to isolate ethyl 2-(2,4-difluorophenyl)-2H-tetrazole-5-carboxylate (0.6 g, 2.36 mmol, 31% yield) as a brown coloured solid. Step 2: Synthesis of 2-(2,4-difluorophenyl)-2H-tetrazole-5-carboxylic acid A solution of ethyl 2-(2,4-difluorophenyl)-2H-tetrazole-5-carboxylate (0.6 g, 2.36 mmol) in 1:1:1 15 mixture of ethanol, tetrahydrofuran and water (6 mL) was treated with LiOH (226 mg, 9.44 mmol) at 25 °C, and stirred for 16 h. After the completion of the reaction, the volatiles were removed under reduced pressure. The residue obtained was acidified with 10% aqueous hydrochloric acid to adjust pH 4. The precipitated solid product was filtered off and dried under reduced pressure to obtain 2-(2,4- difluorophenyl)-2H-tetrazole-5-carboxylic acid (0.3 g, 1.33 mmol, 56% yield) as an off white solid. 20 Example 5: 2-(1-methyl-1H-pyrazol-4-yl)-2-(4-methylthiazol-2-yl)propan-1-amine Step a: Synthesis of 2-(1-methyl-1H-pyrazol-4-yl)propanenitrile A solution of tosylmethyl isocyanide (12.3 g, 62.8 mmol) in dimethyl sulfoxide (60 mL) was treated with potassium tert-butoxide (19 g, 169 mmol) at 0 °C under stirring. To this reaction mixture, methanol 25 (6.0 mL) followed by 1-(1-methyl-1H-pyrazol-4-yl)ethan-1-one (6 g, 48.3 mmol) was added and stirred at 25 °C for 4 h. After the completion of the reaction, the reaction mixture was poured into ice water and extracted with ethyl acetate (3 x 80 mL). The combined organic layer was dried over anhydrous sodium sulphate and evaporated under reduced pressure. The obtained residue was purified by flash chromatography to obtain 2-(1-methyl-1H-pyrazol-4-yl)propanenitrile (3.4 g, 25.2 mmol, 52% yield) 30 as a brown oil. GCMS (m / z): 135.2. PI External Step b: Synthesis of 2-(1-methyl-1H-pyrazol-4-yl)-2-(4-methylthiazol-2-yl)propanenitrile To a solution of 2-(1-methyl-1H-pyrazol-4-yl)propanenitrile (15 g, 111 mmol) in tetrahydrofuran (300 mL), n-hexyllithium (63.5 mL, 111 mmol) was added at -78 °C and stirred further for 10 mins. The resulting reaction mixture was further treated with a solution of 2-chloro-4-methylthiazole (11.9 g, 89 5 mmol) in THF (20 mL). The reaction mixture was stirred at -78 °C for 10 mins and then gradually warmed to 0 °C and stirred further for 30 min. After the completion of the reaction, the reaction mixture was poured into water (10 mL) and extracted with ethyl acetate (2 x 200 mL). The combined organic layer was washed with brine solution (100 mL), dried over anhydrous sodium sulphate and evaporated under reduced pressure to obtain crude 2-(1-methyl-1H-pyrazol-4-yl)-2-(4-methylthiazol-2- 10 yl)propanenitrile (13.2 g, 57 mmol, 51% yield) as pale yellow solid. LCMS (m / z): 232.85. Step c: Synthesis of 2-(1-methyl-1H-pyrazol-4-yl)-2-(4-methylthiazol-2-yl)propan-1-amine To a solution of 2-(1-methyl-1H-pyrazol-4-yl)-2-(4-methylthiazol-2-yl)propanenitrile (1 g, 4.3 mmol) in methanol (20 mL), Cobalt(II) chloride (0.84 g, 6.5 mmol) and Sodium borohydride (0.57 g, 15.1 mmol) were added at 0 °C and stirred for 30 min. After the completion of the reaction, the reaction 15 mixture was acidified with 1 N HCl and stirred for 15 mins and then basified with 2 N NaOH solution to pH~10 and filtered through celite pad. The filtrate was extracted with dichloromethane (3 x 20 mL). The combined organic layer was dried over anhydrous sodium sulfate and evaporated under reduced pressure to obtain 2-(1-methyl-1H-pyrazol-4-yl)-2-(4-methylthiazol-2-yl)propan-1-amine (0.63 g, 2.7 mmol, 63% yield). LCMS (m / z): 237.00. 20 Example 5 (step-d): Synthesis of N-(2-(6-chloropyridin-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propyl)-1- (2,4-difluorophenyl)-1H-1,2,3-triazole-4-carboxamide (compound 1) A solution of 1-(2,4-difluorophenyl)-1H-1,2,3-triazole-4-carboxylic acid (350 mg, 1.55 mmol) and 2- (6-chloropyridin-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propan-1-amine (409 mg, 1.63 mmol) in25 dichloromethane (10 mL) was treated sequentially with triethylamine (0.6 mL, 4.66 mmol) and 1- propanephosphonic acid cyclic anhydride (1.48 g, 2.33 mmol) at 25 °C, and stirred for 18 h. After the completion of the reaction, water (60 mL) was added to the reaction mixture and extracted with dichloromethane (3 x 40 mL). The combined organic layers were washed with saturated brine solution (50 mL), dried over anhydrous sodium sulphate, filtered and evaporated under reduced pressure. The 30 crude material thus obtained was purified by reverse phase preparative-high performance liquid PI External chromatography to isolate N-(2-(6-chloropyridin-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propyl)-1-(2,4- difluorophenyl)-1H-1,2,3-triazole-4-carboxamide 1 (200 mg, 0.44 mmol, 28% yield) as a white solid. LCMS (m / Z): 457.9 1H-NMR (400 MHz, DMSO-D6) δ 9.02 (d, J = 1.5 Hz, 1H), 8.15 (t, J = 6.4 Hz, 1H), 7.91 (td, J = 8.8, 5 5.9 Hz, 1H), 7.78 (t, J = 7.8 Hz, 1H), 7.73-7.67 (m, 1H), 7.62 (s, 1H), 7.39-7.34 (m, 3H), 7.27 (dd, J = 7.9, 0.6 Hz, 1H), 4.04 (q, J = 6.5 Hz, 1H), 3.87 (q, J = 6.6 Hz, 1H), 3.77 (s, 3H), 1.63 (s, 3H) Example 6 (step-d): Synthesis of N-(2-(4-chlorothiazol-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propyl)-1- (2,4-difluorophenyl)-1H-1,2,3-triazole-4-carboxamide (compound 2) 10 A solution of 1-(2,4-difluorophenyl)-1H-1,2,3-triazole-4-carboxylic acid (275 mg, 1.22 mmol) and 2- (4-chlorothiazol-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propan-1-amine (314 mg, 1.22 mmol) in dichloromethane (5 mL) was treated with triethylamine (0.5 mL, 3.66 mmol) and 1-propanephosphonic acid cyclic anhydride (0.972 g, 1.53 mmol) at 25 °C, and stirred for 18 h. After the completion of the 15 reaction, water (60 mL) was added to the reaction mixture and, extracted with dichloromethane (3 x 50 mL). The combined organic extracts were washed with saturated brine solution (40 mL), dried over anhydrous sodium sulphate, filtered and evaporated under reduced pressure. The crude material thus obtained was purified by a reverse phase preparative-high performance liquid chromatography to isolate N-(2-(4-chlorothiazol-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propyl)-1-(2,4-difluorophenyl)-1H-1,2,3- 20 triazole-4-carboxamide 2 (200 mg, 0.43 mmol, 35% yield) as an off white solid. LCMS (m / z): 463.85 1H-NMR (400 MHz, DMSO-D6) δ 9.04 (d, J = 1.5 Hz, 1H), 8.35 (t, J = 6.4 Hz, 1H), 7.92 (td, J = 8.9, 5.8 Hz, 1H), 7.80 (s, 1H), 7.73-7.67 (m, 1H), 7.61 (s, 1H), 7.51 (d, J = 0.9 Hz, 1H), 7.39-7.34 (m, 1H), 4.01 (q, J = 6.5 Hz, 1H), 3.87 (q, J = 6.6 Hz, 1H), 3.81 (s, 3H), 1.69 (s, 3H) 25 Example 7 (step-d): Synthesis of N-(2-(6-chloropyridin-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propyl)-1- (2,4-difluorophenyl)-1H-pyrazole-4-carboxamide (compound 3) PI External A solution of 1-(2,4-difluorophenyl)-1H-pyrazole-4-carboxylic acid (300 mg, 1.34 mmol) and 2-(6- chloropyridin-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propan-1-amine (336 mg, 1.34 mmol) in dichloromethane (5 mL) was treated with triethylamine (0.56 mL, 4.01 mmol) and 1- propanephosphonic acid cyclic anhydride (1.07 g, 1.67 mmol) at 25 °C, and stirred for 18 h. After the 5 completion of the reaction, water (60 mL) was added to the reaction mixture and extracted with dichloromethane (3 x 60 mL). The combined organic extracts were washed with saturated brine solution (40 mL), dried over anhydrous sodium sulphate, filtered, and evaporated under reduced pressure. The crude material thus obtained was purified by a reverse phase preparative-high performance liquid chromatography to isolate N-(2-(6-chloropyridin-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propyl)-1-(2,4- 10 difluorophenyl)-1H-pyrazole-4-carboxamide 3 (205 mg, 0.45 mmol, 33% yield) as a white solid. LCMS (m / z): 457 1H-NMR (400 MHz, DMSO-D6) δ 8.60 (d, J = 2.0 Hz, 1H), 8.10 (s, 1H), 7.89 (t, J = 6.2 Hz, 1H), 7.82 (td, J = 9.0, 6.0 Hz, 1H), 7.75 (t, J = 7.8 Hz, 1H), 7.61-7.55 (m, 2H), 7.33-7.24 (m, 4H), 3.98 (dd, J = 13.4, 6.1 Hz, 1H), 3.83 (q, J = 6.6 Hz, 1H), 3.76 (s, 3H), 1.63 (s, 3H) 15 Example 8 (step-d): Synthesis of N-(2-(4-chlorothiazol-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propyl)-1- (2,4-difluorophenyl)-1H-pyrazole-4-carboxamide (compound 4) A solution of 1-(2,4-difluorophenyl)-1H-pyrazole-4-carboxylic acid (250 mg, 1.12 mmol) and 2-(4- 20 chlorothiazol-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propan-1-amine (286 mg, 1.12 mmol) in dichloromethane (5 mL) was treated with triethylamine (0.339 g, 3.35 mmol) and 1-propanephosphonic acid cyclic anhydride (0.887 g, 1.394 mmol) at 25 °C, and stirred for 18 h. After the completion of the reaction, water (60 mL) was added to the reaction mixture and extracted with dichloromethane (3 x 50 mL). The combined organic extracts were washed with saturated brine solution (40 mL), dried over 25 anhydrous sodium sulphate, filtered and evaporated under reduced pressure. The crude material thus obtained was purified by a reverse phase preparative-high performance liquid chromatography to isolate N-(2-(4-chlorothiazol-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propyl)-1-(2,4-difluorophenyl)-1H- pyrazole-4-carboxamide 4 (290 mg, 0.67 mmol, 56% yield) as a white solid. LCMS (m / z): 463.05 PI External 1H-NMR (400 MHz, DMSO-D6) δ 8.63 (d, J = 2.0 Hz, 1H), 8.13 (s, 1H), 8.10 (t, J = 6.4 Hz, 1H), 7.83 (td, J = 9.0, 5.9 Hz, 1H), 7.75 (s, 1H), 7.62-7.56 (m, 2H), 7.47 (d, J = 0.7 Hz, 1H), 7.30-7.25 (m, 1H), 3.93 (q, J = 6.5 Hz, 1H), 3.83 (t, J = 6.7 Hz, 1H), 3.80 (s, 3H), 1.68 (s, 3H) 5 Example 9 (step-d): N-(2-(6-chloropyridin-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propyl)-2-(2,4- difluorophenyl)-2H-1,2,3-triazole-4-carboxamide (compound 5) A solution of 2-(2,4-difluorophenyl)-2H-1,2,3-triazole-4-carboxylic acid (0.3 g, 1.33 mmol) and 2-(6- chloropyridin-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propan-1-amine (334 mg, 1.33 mmol) in 10 dichloromethane (5 mL) was treated with triethylamine (0.6 mL, 4 mmol) and 1-propanephosphonic acid cyclic anhydride (1.06 g, 1.67 mmol) at 25 °C, and stirred for 18 h. After the completion of the reaction, water (60 mL) was added to the reaction mixture and extracted with dichloromethane (3 x 50 mL). The combined organic exracts were washed with saturated brine solution (40 mL), dried over anhydrous sodium sulphate, filtered and evaporated under reduced pressure. The crude material thus 15 obtained was purified by a reverse phase preparative-high performance liquid chromatography to isolate N-(2-(6-chloropyridin-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propyl)-2-(2,4-difluorophenyl)-2H-1,2,3- triazole-4-carboxamide 5 (310 mg, 0.68 mmol, 51% yield) as a pale-yellow gum. LCMS (m / z): 458 1H-NMR (400 MHz, DMSO-D6) δ 8.46 (s, 1H), 8.24 (t, J = 6.5 Hz, 1H), 7.93 (td, J = 8.8, 5.9 Hz, 1H), 20 7.76 (t, J = 7.8 Hz, 1H), 7.69-7.63 (m, 1H), 7.59 (s, 1H), 7.37-7.32 (m, 3H), 7.26 (dd, J = 7.7, 0.6 Hz, 1H), 4.01 (q, J = 6.6 Hz, 1H), 3.85 (q, J = 6.7 Hz, 1H), 3.76 (s, 3H), 1.62 (s, 3H) Example 10 (step-d): N-(2-(4-chlorothiazol-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propyl)-2-(2,4- difluorophenyl)-2H-1,2,3-triazole-4-carboxamide (compound 6) 25 A solution of 2-(2,4-difluorophenyl)-2H-1,2,3-triazole-4-carboxylic acid (0.25 g, 1.11 mmol) and 2-(4- chlorothiazol-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propan-1-amine (285 mg, 1.11 mmol) in PI External dichloromethane (5 mL) was treated with triethylamine (0.5 mL, 3.33 mmol) and 1-propanephosphonic acid cyclic anhydride (0.88 g, 1.39 mmol) at 25 °C, and stirred for 18 h. After the completion of the reaction, water (60 mL) was added to the reaction mixture and extracted with ethyl acetate (2 x 50 mL). The combined organic extracts were dried over anhydrous sodium sulphate and evaporated under 5 reduced pressure to obtain a crude compound, which was then purified by reverse phase preparative- high performance liquid chromatography to isolate N-(2-(4-chlorothiazol-2-yl)-2-(1-methyl-1H- pyrazol-4-yl)propyl)-2-(2,4-difluorophenyl)-2H-1,2,3-triazole-4-carboxamide 6 (240 mg, 0.52 mmol, 47% yield) as a pale-yellow solid. LCMS (m / z): 464.15 101H-NMR (400 MHz, DMSO-D6) δ 8.47 (s, 1H), 8.43 (t, J = 6.4 Hz, 1H), 7.94 (td, J = 8.8, 5.9 Hz, 1H), 7.78 (s, 1H), 7.70-7.64 (m, 1H), 7.59 (s, 1H), 7.49 (d, J = 0.7 Hz, 1H), 7.38-7.34 (m, 1H), 3.98 (q, J = 6.6 Hz, 1H), 3.84 (q, J = 6.6 Hz, 1H), 3.80 (s, 3H), 1.69 (s, 3H) Example 11 (step-d): N-(2-(4-chlorothiazol-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propyl)-2-(2,4- 15 difluorophenyl)-2H-tetrazole-5-carboxamide (compound 7) A solution of 2-(2,4-difluorophenyl)-2H-tetrazole-5-carboxylic acid (300 mg, 1.33 mmol) and 2-(4- chlorothiazol-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propan-1-amine (307 mg, 1.19 mmol) in dichloromethane (10 mL) was treated with triethylamine (0.6 ml, 3.98 mmol) and 1-propanephosphonic 20 acid cyclic anhydride (1.06 g, 1.66 mmol) at 25 °C, and stirred for 18 h. After the completion of the reaction, water (50 mL) was added to the reaction mixture and extracted with ethyl acetate (2 x 60 mL). The combined organic extracts were dried over anhydrous sodium sulphate and evaporated under reduced pressure to obtain a crude compound, which was then purified by reverse phase preparative- high performance liquid chromatography to isolate N-(2-(4-chlorothiazol-2-yl)-2-(1-methyl-1H- 25 pyrazol-4-yl)propyl)-2-(2,4-difluorophenyl)-2H-tetrazole-5-carboxamide 7 (200 mg, 0.43 mmol, 32% yield) as a brown solid. LCMS (m / z): 465.1 1H-NMR (400 MHz, DMSO-D6) δ 8.96 (t, J = 6.5 Hz, 1H), 8.07 (td, J = 8.8, 5.8 Hz, 1H), 7.82-7.77 (m, 2H), 7.61 (s, 1H), 7.51 (d, J = 1.0 Hz, 1H), 7.47-7.42 (m, 1H), 4.07-3.98 (m, 1H), 3.89 (q, J = 6.6 30 Hz, 1H), 3.81 (s, 3H), 1.71 (s, 3H) PI External Example 12 (step-d): N-(2-(6-chloropyridin-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propyl)-2-(2,4- difluorophenyl)-2H-tetrazole-5-carboxamide (compound 8) A solution of 2-(2,4-difluorophenyl)-2H-tetrazole-5-carboxylic acid (300 mg, 1.33 mmol) and 2-(6- 5 chloropyridin-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propan-1-amine (333 mg, 1.33 mmol) in dichloromethane (5 mL) was treated with triethylamine (0.6 mL, 3.98 mmol) and 1-propanephosphonic acid cyclic anhydride (1.06 g, 1.66 mmol) at 25 °C, and stirred for 18 h. After the completion of the reaction, water (40 mL) was added to the reaction mixture and extracted with ethyl acetate (2 x 50 mL). The combined organic extracts were dried over anhydrous sodium sulphate and evaporated under10 reduced pressure to obtain a crude compound, which was then purified by a reverse phase preparative- high performance liquid chromatography to isolate N-(2-(6-chloropyridin-2-yl)-2-(1-methyl-1H- pyrazol-4-yl)propyl)-2-(2,4-difluorophenyl)-2H tetrazole-5-carboxamide 8 (150 mg, 0.33 mmol, 25% yield) as a pale-yellow gum. LCMS (m / z): 459.25 151H-NMR (400 MHz, DMSO-D6) δ 8.74 (t, J = 6.5 Hz, 1H), 8.06 (td, J = 8.7, 5.9 Hz, 1H), 7.82-7.76 (m, 2H), 7.61 (s, 1H), 7.47-7.42 (m, 1H), 7.37 (dd, J = 7.8, 0.7 Hz, 1H), 7.34 (d, J = 0.7 Hz, 1H), 7.28 (dd, J = 7.8, 0.5 Hz, 1H), 4.07 (q, J = 6.6 Hz, 1H), 3.90 (q, J = 6.6 Hz, 1H), 3.77 (s, 3H), 1.65 (s, 3H). Example 13 (step-d): Synthesis of N-(2-(1-methyl-1H-pyrazol-4-yl)-2-(4-methylthiazol-2-yl)propyl)- 2-phenyl-2H-tetrazole-5-carboxamide (compound 140) 20 To a solution of 2-phenyl-2H-tetrazole-5-carboxylic acid (0.14 g, 0.74 mmol) in dichloromethane (4 mL) was treated with triethyl amine (0.21 mL, 1.48 mmol) and 2-(1-methyl-1H-pyrazol-4-yl)-2-(4- methylthiazol-2-yl)propan-1-amine (0.25 g, 0.740 mmol) were added at 0 °C. This reaction mass was further treated with 1-Propanephosphonic acid cyclic anhydride (0.5 mL, 0.82 mmol) and stirred at 25 25 °C for 8 h. After the completion of the reaction, the reaction mixture was poured into water and extracted with dichloromethane (3 x 25 mL). The combined organic layer was washed with brine solution (25 mL), dried over anhydrous sodium sulphate, filtered and evaporated under reduced pressure. The residual material was purified by reverse phase preparative-high performance liquid chromatography PI External to isolate N-(2-(1-methyl-1H-pyrazol-4-yl)-2-(4-methylthiazol-2-yl)propyl)-2-phenyl-2H-tetrazole-5- carboxamide (235 mg, 0.56 mmol, 78% yield). Table 1: Representative compounds of the present disclosure were prepared according to the methods as described above by employing the suitable starting materials: Comp. No IUPAC Name Analytical Data 1 1-(2-chloro-4-methylphenyl)-N- H-NMR (400 MHz, DMSO-D6) δ 8.61-8.58 (m, 1H), 7.78 (2-(6-chloropyridin-2-yl)-2-(1- (t, J = 7.8 Hz, 1H), 7.73 (d, J = 8.1 Hz, 1H), 7.66 (d, J = 1.0 methyl-1H-pyraz Hz, 1H), 7.61 (s, 1H), 7.43 (dd, J = 8.2, 1.1 Hz, 1H), 7.37 9 ol-4- yl)propyl)-5-(trifluoromethyl)- (dd, J = 7.8, 0.7 Hz, 1H), 7.35 (d, J = 0.7 Hz, 1H), 7.29 (dd, 1H-1,2,3-triazole-4- J = 7.7, 0.6 Hz, 1H), 4.06 (d, J = 32.0 Hz, 1H), 3.96-3.84 carboxamide (m, 1H), 3.77 (s, 3H), 2.43 (s, 3H), 1.65 (s, 3H); LCMS (m / z): 538.15 N-(2-(6-chloropyridin-2-yl)-2-1H-NMR (400 MHz, DMSO-D6) δ 8.15-8.12 (m, 3H), 7.79 (1-methyl-1H-pyrazol-4- (t, J = 7.9 Hz, 1H), 7.63 (d, J = 0.5 Hz, 1H), 7.39-7.36 (m, 10 yl)propyl)-5-methyl-1-(2,4,6- 2H), 7.28 (dd, J = 7.8, 0.7 Hz, 1H), 4.03 (dd, J = 13.3, 6.3 trichlorophenyl)-1H-1,2,3- Hz, 1H), 3.86 (q, J = 6.7 Hz, 1H), 3.78 (s, 3H), 2.33 (s, 3H), triazole-4-carboxamide 1.63 (s, 3H); LCMS (m / z): 539.9 1H-NMR (400 MHz, DMSO-D6) δ 8.08 (t, J = 6.4 Hz, 1H), 1-(2-chloro-4-fluorophenyl)-N- 7.90-7.85 (m, 2H), 7.79 (t, J = 7.8 Hz, 1H), 7.62 (d, J = 0.6 (2-(6-chloropyridin-2-yl)-2-(1- Hz, 1H), 7.53 (td, J = 8.4, 2.9 Hz, 1H), 7.38 (dd, J = 7.9, 0.6 11 methyl-1H-pyrazol-4- Hz, 1H), 7.35 (d, J = 0.6 Hz, 1H), 7.29-7.27 (m, 1H), 4.03 yl)propyl)-5-ethyl-1H-1,2,3- (dd, J = 13.1, 6.1 Hz, 1H), 3.89-3.84 (m, 1H), 3.77 (s, 3H), triazole-4-carboxamide 2.74 (d, J = 4.9 Hz, 2H), 1.63 (s, 3H), 0.95 (t, J = 7.6 Hz, 3H); LCMS (m / z): 502.25 1H-NMR (400 MHz, DMSO-D6) δ 8.04 (t, J = 6.4 Hz, 1H), 1-(2-chloro-4-methylphenyl)-N- 7.79 (t, J = 7.8 Hz, 1H), 7.64 (d, J = 0.9 Hz, 1H), 7.63 (s, (2-(6-chloropyridin-2-yl)-2-(1- 1H), 7.56 (d, J = 8.3 Hz, 1H), 7.43-7.40 (m, 1H), 7.39-7.37 12 methyl-1H-pyrazol-4- (m, 1H), 7.36 (d, J = 0.9 Hz, 1H), 7.29-7.27 (m, 1H), 4.03 yl)propyl)-5-methyl-1H-1,2,3- (q, J = 6.5 Hz, 1H), 3.86 (q, J = 6.7 Hz, 1H), 3.78 (s, 3H), triazole-4-carboxamide 2.42 (s, 3H), 2.30 (s, 3H), 1.63 (s, 3H); LCMS (m / z): 484.15 1-(3,5-1H-NMR (400 MHz, DMSO-D6) δ 9.61 (s, 1H), 8.69 (s, bis(trifluoromethyl)phenyl)-N- 2H), 8.31 (s, 1H), 8.24 (t, J = 6.4 Hz, 1H), 7.78 (t, J = 7.8 13 (2-(6-chloropyridin-2-yl)-2-(1- Hz, 1H), 7.62 (s, 1H), 7.40-7.38 (m, 1H), 7.34 (d, J = 0.7 methyl-1H-pyrazol-4- Hz, 1H), 7.27 (d, J = 7.1 Hz, 1H), 4.05 (q, J = 6.5 Hz, 1H), yl)propyl)-1H-1,2,3-triazole-4- 3.88 (q, J = 6.6 Hz, 1H), 3.77 (s, 3H), 1.63 (s, 3H); LCMS carboxamide (m / z): 558.2 N-(2-(6-chloropyridin-2-yl)-2-1(1-methyl-1H-pyrazol-4- H-NMR (400 MHz, DMSO-D6) δ 8.62 (s, 1H), 8.09 (d, J yl)propyl)-1- = 2.2 Hz, 1H), 7.97 (d, J = 8.6 Hz, 1H), 7.80-7.76 (m, 2H), 14 (2,4- dichlorophenyl)-5- 7.61 (s, 1H), 7.38-7.36 (m, 1H), 7.35 (d, J = 0.7 Hz, 1H), (trifluoromethyl)-1H-1,2,3- 7.28 (d, J = 7.8 Hz, 1H), 4.06 (d, J = 34.7 Hz, 1H), 3.94 (s, triazole-4-carboxamide 1H), 3.77 (s, 3H), 1.65 (s, 3H); LCMS (m / z): 560 1H-NMR (400 MHz, DMSO-D6) δ 8.08 (t, J = 6.4 Hz, 1H), N-(2-(6-chloropyridin-2-yl)-2- 7.87 (d, J = 2.2 Hz, 1H), 7.79 (td, J = 7.8, 0.7 Hz, 1H), 7.70 (1-methyl-1H-pyrazol-4- (t, J = 1.1 Hz, 1H), 7.63 (d, J = 1.5 Hz, 1H), 7.38 (d, J = 7.8 15 yl)propyl)-1-(2,4-dichloro-6- Hz, 1H), 7.36 (t, J = 1.1 Hz, 1H), 7.30-7.27 (m, 1H), 4.03 methylphenyl)-5-methyl-1H- (q, J = 6.5 Hz, 1H), 3.85 (q, J = 6.7 Hz, 1H), 3.78 (s, 3H), 1,2,3-triazole-4-carboxamide 2.30 (s, 3H), 1.97-1.95 (m, 3H), 1.63 (s, 3H); LCMS (m / z): 518.25 PI External 1 1-(4-chloro-2-fluorophenyl)-N- H-NMR (400 MHz, DMSO-D6) δ 8.07 (t, J = 6.5 Hz, 1H), (2-(6-chloropyridin-2-yl)-2-(1- 7.90 (dd, J = 10.0, 2.2 Hz, 1H), 7.81-7.75 (m, 2H), 7.62 (d, 16 methyl-1H-pyrazol-4- J = 0.5 Hz, 1H), 7.61-7.58 (m, 1H), 7.38 (dd, J = 7.8, 0.5 yl)propyl)-5-methyl-1H-1,2,3- Hz, 1H), 7.35 (d, J = 1.0 Hz, 1H), 7.27 (dd, J = 7.8, 0.5 Hz, triazole-4-carboxamide 1H), 4.03 (q, J = 6.5 Hz, 1H), 3.86 (q, J = 6.7 Hz, 1H), 3.78 (s, 3H), 2.39 (s, 3H), 1.62 (s, 3H); LCMS (m / z): 488.1 1-(3-chloro-5-1H-NMR (400 MHz, DMSO-D6) δ 9.50 (s, 1H), 8.44 (t, J = (trifluoromethyl)phenyl)-N-(2- 1.7 Hz, 1H), 8.34 (s, 1H), 8.21 (t, J = 6.5 Hz, 1H), 8.06 (s, 17 (6-chloropyridin-2-yl)-2-(1- 1H), 7.78 (t, J = 7.8 Hz, 1H), 7.61 (s, 1H), 7.38 (dd, J = 7.8, methyl-1H-pyrazol-4- 0.7 Hz, 1H), 7.34 (d, J = 0.7 Hz, 1H), 7.27 (dd, J = 7.7, 0.6 yl)propyl)-1H-1,2,3-triazole-4- Hz, 1H), 4.04 (q, J = 6.6 Hz, 1H), 3.87 (q, J = 6.6 Hz, 1H), carboxamide 3.77 (s, 3H), 1.63 (s, 3H); LCMS (m / z): 524.15 1H-NMR (400 MHz, DMSO-D6) δ 8.05 (t, J = 6.4 Hz, 1H), 1-(2-chloro-4-fluorophenyl)-N- 7.88-7.85 (m, 2H), 7.78 (t, J = 7.8 Hz, 1H), 7.61 (s, 1H), (2-(6-chloropyridin-2-yl)-2-(1- 7.52 (td, J = 8.4, 2.7 Hz, 1H), 7.37 (dd, J = 7.8, 0.7 Hz, 1H), 18 methyl-1H-pyrazol-4- 7.34 (d, J = 0.7 Hz, 1H), 7.28 (d, J = 7.8 Hz, 1H), 4.02 (q, J yl)propyl)-5-cyclopropyl-1H- = 6.4 Hz, 1H), 3.85 (q, J = 6.6 Hz, 1H), 3.78 (s, 3H), 1.83- 1,2,3-triazole-4-carboxamide 1.76 (m, 1H), 1.62 (s, 3H), 0.90-0.79 (m, 4H); LCMS (m / z): 514.1 1 N-(2-(6-chloropyridin-2-yl)-2- H-NMR (400 MHz, DMSO-D6) δ 8.06 (t, J = 6.4 Hz, 1H), (1-methyl-1H-pyrazol-4- 7.84-7.77 (m, 2H), 7.74-7.68 (m, 1H), 7.62 (d, J = 0.6 Hz, 19 yl)propyl)-1-(2,4- 1H), 7.42-7.37 (m, 2H), 7.35 (d, J = 0.9 Hz, 1H), 7.27 (dd, J difluorophenyl)-5-methyl-1H- = 7.8, 0.8 Hz, 1H), 4.03 (q, J = 6.5 Hz, 1H), 3.86 (q, J = 6.6 1,2,3-triazole-4-carboxamide Hz, 1H), 3.78 (s, 3H), 2.38 (s, 3H), 1.62 (s, 3H) LCMS (m / z): 471.9 (1-(2,4-difluorophenyl)-5-1H-NMR (400 MHz, DMSO-D6) δ 7.83 (td, J = 15.0, 8.8 methyl-1H-1,2,3-triazol-4-yl)(4- Hz, 1H), 7.75-7.69 (m, 1H), 7.48-7.30 (m, 2H), 7.25 (t, J = 20 (1-methyl-1H-pyrazol-4-yl)-3,4- 7.5 Hz, 1H), 7.19-6.99 (m, 4H), 5.27-5.09 (m, 1H), 4.73 (d, dihydroisoquinolin-2(1H)- J = 17.1 Hz, 1H), 4.41-4.16 (m, 2H), 4.06-3.95 (m, 1H), yl)methanone 3.66 (s, 3H), 2.09 (s, 3H); LCMS (m / z): 435.25 1H-NMR (400 MHz, DMSO-D6) δ 9.03 (d, J = 1.5 Hz, N-(2-(6-chloropyridin-2-yl)-2- 1H), 8.15 (t, J = 6.4 Hz, 1H), 7.83 (td, J = 7.8, 1.5 Hz, 1H), (1-methyl-1H-pyrazol-4- 7.78 (t, J = 7.9 Hz, 1H), 7.67-7.55 (m, 3H), 7.46-7.42 (m, 21 yl)propyl)-1-(2-fluorophenyl)- 1H), 7.38 (d, J = 7.9 Hz, 1H), 7.35 (d, J = 0.6 Hz, 1H), 7.28 1H-1,2,3-triazole-4- (dd, J = 7.6, 0.6 Hz, 1H), 4.05 (q, J = 6.6 Hz, 1H), 3.87 (q, J carboxamide = 6.6 Hz, 1H), 3.77 (s, 3H), 1.63 (s, 3H); LCMS (m / z): 440.15 1H-NMR (400 MHz, DMSO-D6) δ 9.28 (s, 1H), 8.11 (t, J = N-(2-(6-chloropyridin-2-yl)-2- 6.4 Hz, 1H), 7.95-7.92 (m, 2H), 7.78 (t, J = 7.8 Hz, 1H), 22 (1-methyl-1H-pyrazol-4- 7.62-7.57 (m, 3H), 7.53-7.49 (m, 1H), 7.38 (dd, J = 7.9, 0.6 yl)propyl)-1-phenyl-1H-1,2,3- Hz, 1H), 7.34 (d, J = 0.6 Hz, 1H), 7.27 (dd, J = 7.6, 0.6 Hz, triazole-4-carboxamide 1H), 4.05 (q, J = 6.6 Hz, 1H), 3.87 (q, J = 6.6 Hz, 1H), 3.77 (s, 3H), 1.63 (s, 3H); LCMS (m / z): 422.05 1 N-(2-(4-chlorothiazol-2-yl)-2- H-NMR (400 MHz, DMSO-D6) δ 9.05 (d, J = 1.8 Hz, (1-methyl-1H-pyrazol-4- 1H), 8.34 (t, J = 6.6 Hz, 1H), 7.84 (td, J = 7.9, 1.6 Hz, 1H), 23 yl)propyl)-1-(2-fluorophenyl)- 7.81 (s, 1H), 7.67-7.56 (m, 3H), 7.51 (d, J = 0.6 Hz, 1H), 1H-1,2,3-triazole-4- 7.45 (td, J = 7.7, 1.0 Hz, 1H), 4.01 (q, J = 6.6 Hz, 1H), 3.87 carboxamide (q, J = 6.6 Hz, 1H), 3.81 (s, 3H), 1.70 (s, 3H); LCMS (m / z): 445.9 N-(2-(4-chlorothiazol-2-yl)-2-1H-NMR (400 MHz, DMSO-D6) δ 7.86 (t, J = 6.4 Hz, 1H), 24 (1-methyl-1H-pyrazol-4- 7.77 (s, 1H), 7.69 (td, J = 8.9, 6.1 Hz, 1H), 7.63-7.52 (m, yl)propyl)-1-(2,4- 2H), 7.48 (d, J = 0.6 Hz, 1H), 7.33-7.28 (m, 1H), 6.64 (d, J PI External difluorophenyl)-5-methyl-1H- = 0.6 Hz, 1H), 3.93 (q, J = 6.6 Hz, 1H), 3.81-3.77 (m, 4H), pyrazole-3-carboxamide 2.15 (s, 3H), 1.64 (s, 3H); LCMS (m / z): 476.95 N-(2-(6-chloropyridin-2-yl)-2-1H-NMR (400 MHz, DMSO-D6) δ 7.77-7.73 (m, 2H), 7.68 (1-methyl-1H-pyrazol-4- (td, J = 8.9, 6.1 Hz, 1H), 7.62-7.57 (m, 2H), 7.34-7.27 (m, 25 yl)propyl)-1-(2,4- 3H), 7.24 (d, J = 7.6 Hz, 1H), 6.62 (d, J = 0.6 Hz, 1H), 3.95 difluorophenyl)-5-methyl-1H- (q, J = 6.5 Hz, 1H), 3.79 (t, J = 6.6 Hz, 1H), 3.75 (s, 3H), pyrazole-3-carboxamide 2.14 (s, 3H), 1.58 (s, 3H); LCMS (m / z): 471.25 1H-NMR (400 MHz, DMSO-D6) δ 8.55 (d, J = 2.4 Hz, N-(2-(6-chloropyridin-2-yl)-2- 1H), 8.08 (t, J = 6.4 Hz, 1H), 7.95-7.90 (m, 2H), 7.79 (t, J = (1-meth 7.8 Hz, 1H), 7.60 (d, J = 0.6 Hz, 1H), 7.42-7.36 (m, 3H), 26 yl-1H-pyrazol-4- yl)propyl)-1-(4-fluorophenyl)- 7.33 (d, J = 0.9 Hz, 1H), 7.26 (dd, J = 7.6, 0.6 Hz, 1H), 6.86 1H-pyrazole-3-carboxamide (d, J = 2.4 Hz, 1H), 3.96 (dd, J = 13.4, 6.1 Hz, 1H), 3.82 (q, J = 6.8 Hz, 1H), 3.77 (s, 3H), 1.61 (s, 3H); LCMS (m / z): 439 1 N-(2-(4-chlorothiazol-2-yl)-2- H-NMR (400 MHz, DMSO-D6) δ 8.56 (d, J = 2.8 Hz, (1-methyl-1H- 1H), 8.18 (t, J = 6.4 Hz, 1H), 7.97-7.93 (m, 2H), 7.79 (s, 27 pyrazol-4- yl)propyl)-1-(4-fluorophenyl)- 1H), 7.62 (s, 1H), 7.51 (d, J = 0.9 Hz, 1H), 7.42-7.38 (m, 1H-pyrazole-3-carboxamide 2H), 6.87 (d, J = 2.4 Hz, 1H), 3.94 (q, J = 6.4 Hz, 1H), 3.87-3.81 (m, 4H), 1.68 (s, 3H); LCMS (m / z): 444.95 1H-NMR (400 MHz, DMSO-D6) δ 8.86 (s, 1H), 8.07 (s, N-(2-(6-chloropyridin-2-yl)-2- 1H), 7.86-7.79 (m, 3H), 7.75 (t, J = 7.8 Hz, 1H), 7.58 (s, 28 (1-methyl-1H-pyrazol-4- 1H), 7.38-7.32 (m, 4H), 7.29 (d, J = 7.6 Hz, 1H), 3.98 (dd, J yl)propyl)-1-(4-fluorophenyl)- = 13.4, 6.1 Hz, 1H), 3.83 (q, J = 6.6 Hz, 1H), 3.76 (s, 3H), 1H-pyrazole-4-carboxamide 1.64 (s, 3H) LCMS (m / z): 439.25 1 N-(2-(4-chlorothiazol-2-yl)-2- H-NMR (400 MHz, DMSO-D6) δ 8.89 (s, 1H), 8.11 (s, (1-methyl-1H-pyrazol-4 1H), 8.03 (t, J = 6.3 Hz, 1H), 7.88-7.83 (m, 2H), 7.75 (d, J = 29 - yl)propyl)-1-(4-fluorophenyl)- 2.8 Hz, 1H), 7.57 (s, 1H), 7.47 (d, J = 0.9 Hz, 1H), 7.39- 1H-pyrazole-4-carboxamide 7.32 (m, 2H), 3.97-3.91 (m, 1H), 3.84 (t, J = 6.7 Hz, 1H), 3.80 (s, 3H), 1.69 (s, 3H); LCMS (m / z): 444.95 1 N-(2-(6-chloropyridin-2-yl)-2- H-NMR (400 MHz, DMSO-D6) δ 8.46 (s, 1H), 8.24 (t, J = (1-methyl-1H-pyrazol-4- 6.4 Hz, 1H), 7.86 (td, J = 7.9, 1.5 Hz, 1H), 7.77 (t, J = 7.8 30 yl)propyl)-2-(2-fluorophenyl)- Hz, 1H), 7.63-7.52 (m, 3H), 7.43 (td, J = 7.6, 1.1 Hz, 1H), 2H-1,2,3-triazole-4- 7.35 (td, J = 8.1, 0.7 Hz, 2H), 7.26 (dd, J = 7.8, 0.5 Hz, 1H), carboxamide 4.01 (dd, J = 13.2, 6.1 Hz, 1H), 3.85 (q, J = 6.6 Hz, 1H), 3.76 (s, 3H), 1.63 (s, 3H); LCMS (m / z): 440 N-(2-(4-chlorothiazol-2-yl)-2-1H-NMR (400 MHz, DMSO-D6) δ 8.47 (s, 1H), 8.42 (t, J = (1-methyl-1H-pyrazol-4- 6.4 Hz, 1H), 7.87 (td, J = 7.9, 1.5 Hz, 1H), 7.78 (s, 1H), 31 yl)propyl)-2-(2-fluorophenyl)- 7.64-7.53 (m, 3H), 7.50 (d, J = 0.7 Hz, 1H), 7.43 (td, J = 2H-1,2,3-triazole-4- 7.6, 0.8 Hz, 1H), 3.99 (q, J = 6.6 Hz, 1H), 3.84 (q, J = 6.6 carboxamide Hz, 1H), 3.80 (s, 3H), 1.69 (s, 3H); LCMS (m / z): 445.95 N-(2-(4-bromothiazol-2-yl)-2-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.49 (s, 1H), (1-methyl-1H-pyrazol-4- 7.89-7.83 (m, 2H), 7.41 (d, J = 33.0 Hz, 2H), 7.14 (s, 1H), 32 yl)propyl)-1-(2,4- 7.08 (t, J = 7.9 Hz, 2H), 4.11-4.05 (m, 2H), 3.87 (s, 3H), difluorophenyl)-1H-1,2,3- 1.80 (s, 3H) triazole-4-carboxamide LCMS (m / z): 510.05 1 N-(2-(6-chloropyridin-2-yl)-2- H-NMR (400 MHz, DMSO-D6) δ 8.42 (s, 1H), 8.35 (t, J = (1-methyl-1H-pyrazol-4- 6.4 Hz, 1H), 8.09-8.05 (m, 2H), 7.78 (t, J = 7.8 Hz, 1H), 33 yl)propyl)-2-(4-fluorophenyl)- 7.60 (s, 1H), 7.49-7.44 (m, 2H), 7.38 (dd, J = 7.8, 0.5 Hz, 2H-1,2,3-triazole-4- 1H), 7.33 (d, J = 1.0 Hz, 1H), 7.27 (dd, J = 7.8, 0.7 Hz, 1H), carboxamide 4.00 (dd, J = 13.4, 6.1 Hz, 1H), 3.85 (q, J = 6.7 Hz, 1H), 3.77 (s, 3H), 1.64 (s, 3H); LCMS (m / z): 440.3 34 N-(2-(4-chlorothiazol-2-yl)-2-1H-NMR (400 MHz, DMSO-D6) δ 8.50 (t, J = 6.4 Hz, 1H), (1-methyl-1H-pyrazol-4- 8.43 (s, 1H), 8.10-8.07 (m, 2H), 7.79 (s, 1H), 7.61 (s, 1H), PI External yl)propyl)-2-(4-fluorophenyl)- 7.51-7.45 (m, 3H), 3.98 (dd, J = 13.3, 6.2 Hz, 1H), 3.85 (q, 2H-1,2,3-triazole-4- J = 6.7 Hz, 1H), 3.81 (s, 3H), 1.70 (s, 3H) carboxamide LCMS (m / z): 446.15 N-(2-(4-chlorothiazol-2-yl)-2-1(1-methyl-1H-pyrazol-4- H-NMR (400 MHz, CHLOROFORM-D) δ 8.51 (s, 1H), 35 yl)propyl)-1-(4-fluorophenyl)- 8.07 (s, 1H), 7.72 (d, J = 3.4 Hz, 2H), 7.44 (d, J = 16.5 Hz, 1H-1,2,4-triazole-3- 2H), 7.21 (t, J = 7.9 Hz, 2H), 7.03 (s, 1H), 4.09 (s, 2H), 3.89 carboxamide (s, 3H), 1.81 (s, 3H); LCMS (m / z): 445.9 1 N-(2-(4-chlorothiazol-2-yl)-2- H-NMR (400 MHz, DMSO-D6) δ 8.95 (t, J = 6.4 Hz, 1H), (1-me 7.98 (td, J = 7.7, 1.6 Hz, 1H), 7.80 (s, 1H), 7.79-7.73 (m, 36 thyl-1H-pyrazol-4- yl)propyl)-2-(2-fluorophenyl)- 1H), 7.69-7.64 (m, 1H), 7.61 (s, 1H), 7.54-7.50 (m, 2H), 2H-tetrazole-5-carboxamide 4.05 (q, J = 6.6 Hz, 1H), 3.89 (q, J = 6.6 Hz, 1H), 3.81 (s, 3H), 1.72 (s, 3H); LCMS (m / z): 446.9 1H-NMR (400 MHz, DMSO-D6) δ 8.73 (d, J = 6.4 Hz, N-(2-(6-chloropyridin-2-yl)-2- 1H), 7.97 (td, J = 7.8, 1.5 Hz, 1H), 7.80-7.72 (m, 2H), 7.69- 37 (1-methyl-1H-pyrazol-4- 7.63 (m, 1H), 7.61 (s, 1H), 7.52 (t, J = 8.2 Hz, 1H), 7.36 (td, yl)propyl)-2-(2-fluorophenyl)- J = 7.6, 0.7 Hz, 2H), 7.29-7.27 (m, 1H), 4.07 (dd, J = 13.3, 2H-tetrazole-5-carboxamide 6.2 Hz, 1H), 3.91 (q, J = 6.6 Hz, 1H), 3.77 (s, 3H), 1.65 (s, 3H); LCMS (m / z):441.15 1 N-(2-(4-chlorothiazol-2-yl)-2- H-NMR (400 MHz, DMSO-D6) δ 8.46 (t, J = 6.4 Hz, 1H), (1-methyl-1H-pyrazol-4- 7.79-7.77 (m, 1H), 7.71 (d, J = 5.5 Hz, 1H), 7.56 (d, J = 4.0 38 yl)propyl)-1-(2,4- Hz, 1H), 7.50 (td, J = 8.8, 6.0 Hz, 1H), 7.43-7.37 (m, 2H), difluorophenyl)-1H-pyrazole-3- 7.21-7.16 (m, 1H), 6.97 (d, J = 1.8 Hz, 1H), 3.83 (q, J = 6.5 carboxamide Hz, 1H), 3.79 (s, 3H), 3.75-3.68 (m, 1H), 1.62 (s, 3H); LCMS (m / z): 462.85 1H-NMR (400 MHz, DMSO-D6) δ 8.61 (d, J = 2.7 Hz, 1H), 1-(4-chlorophenyl)-N-(2-(4- 8.23 (t, J = 6.4 Hz, 1H), 7.97-7.94 (m, 2H), 7.80 (d, J = 0.5 39 chlorothiazol-2-yl)-2-(1-methyl- Hz, 1H), 7.63-7.59 (m, 3H), 7.51 (d, J = 0.7 Hz, 1H), 6.89 (d, 1H-pyrazol-4-yl)propyl)-1H- J = 2.4 Hz, 1H), 3.94 (dd, J = 13.3, 6.0 Hz, 1H), 3.85 (t, J = pyrazole-3-carboxamide 6.7 Hz, 1H), 3.81 (d, J = 4.2 Hz, 3H), 1.69 (s, 3H); LCMS (m / z): 461.2 1-(4-chloro-2-fluorophenyl)-N-1H-NMR (400 MHz, DMSO-D6) δ 8.67 (d, J = 2.1 Hz, 1H), 40 (2-(4-chlorothiazol-2-yl)-2-(1- 8.15-8.12 (m, 2H), 7.84 (t, J = 8.6 Hz, 1H), 7.77 (dd, J = 11.3, methyl-1H-pyrazol-4- 2.1 Hz, 2H), 7.57 (s, 1H), 7.46 (dq, J = 8.4, 1.2 Hz, 2H), 3.93 yl)propyl)-1H-pyrazole-4- (q, J = 6.5 Hz, 1H), 3.85-3.76 (m, 4H), 1.68 (s, 3H); LCMS carboxamide (m / z): 478.85 1 N-(2-(4-chlorothiazol-2-yl)-2- H-NMR (400 MHz, DMSO-D6) δ 8.54 (s, 1H), 8.16 (d, J = 1 (1-methyl- 0.6 Hz, 1H), 8.08 (t, J = 6.4 Hz, 1H), 7.76 (d, J = 0.6 Hz, 1H), 4 1H-pyrazol-4- yl)propyl)-1-(2,6- 7.66-7.59 (m, 1H), 7.58 (d, J = 3.7 Hz, 1H), 7.47 (d, J = 0.6 difluorophenyl)-1H-pyrazole-4- Hz, 1H), 7.41-7.36 (m, 2H), 3.93 (q, J = 6.6 Hz, 1H), 3.83 (t, carboxamide J = 6.7 Hz, 1H), 3.78 (d, J = 15.0 Hz, 3H), 1.68 (s, 3H); LCMS (m / z): 462.85 N-(2-(4-chlorothiazol-2-yl)-2-1H-NMR (400 MHz, DMSO-D6) δ 8.54 (d, J = 1.7 Hz, 1H), 42 (1-methyl-1H-pyrazol-4- 8.07 (t, J = 6.0 Hz, 2H), 7.75 (s, 1H), 7.65 (t, J = 9.0 Hz, 1H), yl)propyl)-1-(2-fluoro-4- 7.57 (s, 1H), 7.47 (d, J = 0.7 Hz, 1H), 7.11 (dd, J = 13.2, 2.7 methoxyphenyl)-1H-pyrazole-4- Hz, 1H), 6.93 (dt, J = 9.0, 1.5 Hz, 1H), 3.92 (q, J = 6.6 Hz, carboxamide 1H), 3.84-3.76 (m, 7H), 1.68 (s, 3H); LCMS (m / z): 474.9 1 1-(2-chlorophenyl)-N-(2-(4- H-NMR (400 MHz, DMSO-D6) δ 8.56 (s, 1H), 8.10 (s, 1H), 43 chlorothiazol-2-yl)-2-(1-methyl- 8.04 (t, J = 6.4 Hz, 1H), 7.76 (s, 1H), 7.71-7.66 (m, 1H), 7.63- 1H-pyrazol-4-yl)propyl)-1H- 7.59 (m, 1H), 7.58 (d, J = 4.3 Hz, 1H), 7.55-7.49 (m, 2H), pyrazole-4-carboxamide 7.49-7.47 (m, 1H), 3.97-3.90 (m, 1H), 3.86-3.76 (m, 4H), 1.68 (s, 3H); LCMS (m / z): 460.9 44 1-(2-chloro-4-methylphenyl)-N-1H-NMR (400 MHz, DMSO-D6) δ 8.50 (s, 1H), 8.08 (s, 1H), (2-(4-chlorothiazol-2-yl)-2-(1- 8.03 (t, J = 6.4 Hz, 1H), 7.75 (s, 1H), 7.57 (s, 1H), 7.52 (s, PI External methyl-1H-pyrazol-4- 1H), 7.48-7.46 (m, 2H), 7.32-7.30 (m, 1H), 3.94-3.82 (m, yl)propyl)-1H-pyrazole-4- 2H), 3.80 (s, 3H), 2.37 (s, 3H), 1.68 (s, 3H); LCMS carboxamide (M / Z):LCMS (M / Z): 475.05 1 N-(2-(4-chlorothiazol-2-yl)-2- H-NMR (400 MHz, CHLOROFORM-D) δ 8.30 (d, J = 0.5 (1-methyl-1H-pyraz Hz, 1H), 8.01 (d, J = 0.5 Hz, 1H), 7.57-7.52 (m, 2H), 7.48- 45 ol-4- yl)propyl)-1-(2,4- 7.45 (m, 2H), 7.39 (dd, J = 8.7, 2.3 Hz, 1H), 7.36 (s, 1H), dichlorophenyl)-1H-pyrazole-4- 7.04 (s, 1H), 4.03 (q, J = 6.8 Hz, 1H), 3.94 (dd, J = 13.3, 5.0 carboxamide Hz, 1H), 3.90 (s, 3H), 1.79 (s, 3H); LCMS (M / Z):LCMS (M / Z): 496.7 1 1-(3-chloro-2-fluorophenyl)-N- H-NMR (400 MHz, CHLOROFORM-D) δ 8.43-8.43 (m, (2-(4-c 1H), 8.03 (s, 1H), 7.83-7.79 (m, 1H), 7.48-7.45 (m, 2H), 46 hlorothiazol-2-yl)-2-(1- methyl-1H-pyrazol-4- 7.43-7.39 (m, 1H), 7.36 (d, J = 0.5 Hz, 1H), 7.22 (td, J = 8.2, yl)propyl)-1H-pyrazole-4- 1.6 Hz, 1H), 7.04 (s, 1H), 4.03 (q, J = 6.8 Hz, 1H), 3.95 (dd, carboxamide J = 13.4, 5.1 Hz, 1H), 3.90 (s, 3H), 1.79 (s, 3H); LCMS (M / Z):LCMS (M / Z): 480.65 1 N-(2-(4-chlorothiazol-2-yl)-2- H-NMR (400 MHz, CHLOROFORM-D) δ 8.28 (d, J = 0.7 ( Hz, 1H), 7.95 (d, J = 0.5 Hz, 1H), 7.62-7.58 (m, 2H), 7.45 (d, 47 1-methyl-1H-pyrazol-4- yl)propyl)-1-(4- J = 1.0 Hz, 1H), 7.41 (t, J = 5.9 Hz, 1H), 7.36 (d, J = 0.7 Hz, (trifluoromethyl)phenyl)-1H- 1H), 7.04 (s, 1H), 7.00-6.96 (m, 2H), 4.05-4.00 (m, 1H), 3.94 pyrazole-4-carboxamide (dd, J = 13.4, 4.9 Hz, 1H), 3.89 (s, 3H), 1.79 (s, 3H); LCMS (M / Z):LCMS (M / Z): 495.2 1 N-(2-(4-chlorothiazol-2-yl)-2- H-NMR (400 MHz, CHLOROFORM-D) δ 8.28 (d, J = 0.5 (1-methyl-1H-pyrazol-4- Hz, 1H), 7.95 (d, J = 0.5 Hz, 1H), 7.62-7.58 (m, 2H), 7.45 (d, 48 yl)propyl)-1-(4- J = 0.7 Hz, 1H), 7.42-7.39 (m, 1H), 7.36 (d, J = 0.5 Hz, 1H), methoxyphenyl)-1H-pyrazole-4- 7.04 (s, 1H), 7.00-6.96 (m, 2H), 4.05-4.00 (m, 1H), 3.94 (dd, carboxamide J = 13.3, 5.0 Hz, 1H), 3.89 (s, 3H), 3.85 (s, 3H), 1.79 (s, 3H); LCMS (M / Z):LCMS (M / Z): 457.15 1H-NMR (400 MHz, CHLOROFORM-D) δ 8.46 (s, 1H), N-(2-(4-chlorothiazol-2-yl)-2- 8.03 (s, 1H), 7.87 (dt, J = 9.0, 2.0 Hz, 2H), 7.79 (dt, J = 8.8, 49 (1-methyl-1H-pyrazol-4- 2.1 Hz, 2H), 7.60 (t, J = 5.9 Hz, 1H), 7.44 (d, J = 1.0 Hz, 1H), yl)propyl)-1-(4-cyanophenyl)- 7.36 (s, 1H), 7.05 (s, 1H), 4.02 (q, J = 6.8 Hz, 1H), 3.94 (dd, 1H-pyrazole-4-carboxamide J = 13.4, 4.9 Hz, 1H), 3.90 (s, 3H), 1.79 (s, 3H); LCMS (M / Z): 451.8 N-(2-(4-chlorothiazol-2-yl)-2-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.36 (d, J = 0.7 50 (1-methyl-1H-pyrazol-4- Hz, 1H), 7.99 (s, 1H), 7.90 (q, J = 1.0 Hz, 1H), 7.58-7.52 (m, yl)propyl)-1-(3,4- 3H), 7.45 (d, J = 1.0 Hz, 1H), 7.36 (d, J = 0.7 Hz, 1H), 7.05 dichlorophenyl)-1H-pyrazole-4- (s, 1H), 4.02 (q, J = 6.8 Hz, 1H), 3.93 (dd, J = 13.4, 4.9 Hz, carboxamide 1H), 3.90 (s, 3H), 1.79 (s, 3H); LCMS (M / Z): 494.75 1H-NMR (400 MHz, CHLOROFORM-D) δ 8.42 (d, J = 0.5 N-(2-(4-chlorothiazol-2-yl)-2- Hz, 1H), 8.08 (q, J = 1.2 Hz, 1H), 8.02 (s, 1H), 7.98-7.92 (m, 51 (1-methyl-1H-pyrazol-4- 1H), 7.64-7.53 (m, 3H), 7.45-7.44 (m, 1H), 7.36 (d, J = 3.2 yl)propyl)-1-(3-cyanophenyl)- Hz, 1H), 7.05 (d, J = 2.4 Hz, 1H), 4.08-4.00 (m, 1H), 3.94 1H-pyrazole-4-carboxamide (dd, J = 13.3, 4.8 Hz, 1H), 3.90 (d, J = 3.4 Hz, 3H), 1.79 (d, J = 3.7 Hz, 3H); LCMS (M / Z): 451.95 N-(2-(4-bromothiazol-2-yl)-2-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.26 (s, 1H), 52 (1-methyl-1H-pyrazol-4- 8.01 (s, 1H), 7.47-7.42 (m, 3H), 7.36-7.35 (m, 2H), 7.19 (dd, yl)propyl)-1-(2-chloro-4- J = 8.1, 1.1 Hz, 1H), 7.16 (s, 1H), 4.04 (dd, J = 13.4, 7.3 Hz, methylphenyl)-1H-pyrazole-4- 1H), 3.94 (dd, J = 13.4, 4.9 Hz, 1H), 3.89 (d, J = 5.5 Hz, 3H), carboxamide 2.41 (s, 3H), 1.80 (s, 3H); LCMS (M / Z): 520.55 N-(2-(4-bromothiazol-2-yl)-2-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.32 (d, J = 0.5 (1-methyl-1H-pyrazol-4- Hz, 1H), 8.03 (d, J = 0.5 Hz, 1H), 7.60-7.57 (m, 1H), 7.56- 53 yl)propyl)-1-(2-chlorophenyl)- 7.53 (m, 1H), 7.51-7.48 (m, 1H), 7.45 (d, J = 0.7 Hz, 1H), 1H-pyrazole-4-carboxamide 7.43-7.38 (m, 2H), 7.36 (s, 1H), 7.17 (s, 1H), 4.04 (q, J = 6.8 PI External Hz, 1H), 3.94 (dd, J = 13.4, 4.9 Hz, 1H), 3.89 (d, J = 5.4 Hz, 3H), 1.80 (s, 3H); LCMS (M / Z): 506.7 N-(2-(4-chlorothiazol-2-yl)-2-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.50 (d, J = 2.0 54 (1-methyl-1H-pyrazol-4- Hz, 1H), 8.02 (s, 1H), 7.74-7.69 (m, 1H), 7.53 (t, J = 5.9 Hz, yl)propyl)-1-(2,5- 1H), 7.46 (d, J = 0.7 Hz, 1H), 7.37 (s, 1H), 7.25-7.20 (m, 1H), difluorophenyl)-1H-pyrazole-4- 7.05-6.99 (m, 2H), 4.05-3.93 (m, 2H), 3.91 (s, 3H), 1.79 (s, carboxamide 3H); LCMS (M / Z): 463.15 1 1-(5-chloro-2-fluorophenyl)-N- H-NMR (400 MHz, CHLOROFORM-D) δ 8.47 (d, J = 2.1 Hz, 1H), 8.03 (s, 1H), 7.98 (dd, J = 6.7, 2.4 Hz, 1H), 7.58 (t, 55 (2-(4-chlorothiazol-2-yl)-2-(1- methyl-1H-pyrazol-4- J = 5.8 Hz, 1H), 7.47 (d, J = 0.6 Hz, 1H), 7.38 (s, 1H), 7.29 yl)propyl)-1H-pyrazole-4- (qd, J = 4.3, 2.6 Hz, 1H), 7.24-7.19 (m, 1H), 7.06 (s, 1H), carboxamide 4.02-3.96 (m, 2H), 3.91 (s, 3H), 1.80 (s, 3H); LCMS (M / Z): 478.85 1H-NMR (400 MHz, CHLOROFORM-D) δ 8.44 (d, J = 2.0 1-(5-chloro-2-fluorophenyl)-N- Hz, 1H), 7.99 (s, 1H), 7.95 (dd, J = 6.8, 2.7 Hz, 1H), 7.80- 56 (2-(1-methyl-1H-pyrazol-4-yl)- 7.76 (m, 2H), 7.44 (d, J = 0.7 Hz, 1H), 7.35 (s, 1H), 7.32 (d, 2-(thiazol-2-yl)propyl)-1H- J = 3.4 Hz, 1H), 7.30-7.27 (m, 1H), 7.20 (dd, J = 10.8, 8.8 pyrazole-4-carboxamide Hz, 1H), 4.08-3.93 (m, 2H), 3.90 (s, 3H), 1.83 (s, 3H); LCMS (M / Z): 444.95 1H-NMR (400 MHz, CHLOROFORM-D) δ 8.50 (d, J = 2.7 1-(2,4-difluorophenyl)-N-(2-(1- Hz, 1H), 8.20 (t, J = 6.5 Hz, 1H), 7.93-7.87 (m, 1H), 7.82 (d, 57 ( methyl-1H-pyrazol-4-yl)-2- J = 3.2 Hz, 1H), 7.46 (d, J = 0.7 Hz, 1H), 7.34 (d, J = 0.5 Hz, (thiazol-2-yl)propyl)-1H-1,2,3- 1H), 7.28 (d, J = 3.2 Hz, 1H), 7.12-7.06 (m, 2H), 4.12 (ddd, triazole-4-carboxamide J = 22.2, 13.4, 6.4 Hz, 2H), 3.87 (s, 3H), 1.85 (s, 3H); LCMS (M / Z): 430.65 N-(2-(4-chlorothiazol-2-yl)-2-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.22-8.20 (m, 58 (1-methyl-1H-pyrazol-4- 3H), 7.61-7.52 (m, 3H), 7.46 (s, 1H), 7.39 (s, 1H), 7.05 (s, yl)propyl)-2-phenyl-2H- 1H), 4.15 (d, J = 6.4 Hz, 2H), 3.89 (s, 3H), 1.83 (s, 3H); tetrazole-5-carboxamide LCMS (M / Z): 428.95 1 N-(2-(4-chlorothiazol-2-yl)-2- H-NMR (400 MHz, CHLOROFORM-D) δ 8.38 (s, 1H), 59 (1-methyl-1H-pyrazol-4- 7.99 (s, 1H), 7.70 (t, J = 7.5 Hz, 2H), 7.52-7.43 (m, 4H), 7.36- yl)propyl)-1-phenyl-1H- 7.33 (m, 2H), 7.04 (s, 1H), 4.07-4.01 (m, 1H), 3.95 (dd, J = pyrazole-4-carboxamide 13.4, 4.9 Hz, 1H), 3.89 (s, 3H), 1.79 (s, 3H); LCMS (M / Z): 426.95 1H-NMR (400 MHz, CHLOROFORM-D) δ 8.21 (d, J = 0.7 1-(2-chloro-4-methylphenyl)-N- Hz, 1H), 7.95 (d, J = 0.5 Hz, 1H), 7.77 (d, J = 3.4 Hz, 1H), 60 (2-(1-methyl-1H-pyrazol-4-yl)- 7.58 (t, J = 5.9 Hz, 1H), 7.43-7.41 (m, 2H), 7.34 (d, J = 1.0 2-(thiazol-2-yl)propyl)-1H- Hz, 1H), 7.32 (d, J = 0.5 Hz, 1H), 7.28 (d, J = 3.2 Hz, 1H), pyrazole-4-carboxamide 7.18 (dq, J = 8.1, 0.9 Hz, 1H), 4.00 (d, J = 5.9 Hz, 2H), 3.88 (d, J = 6.4 Hz, 3H), 2.40 (s, 3H), 1.82 (s, 3H); LCMS (M / Z): 441 1H-NMR (400 MHz, CHLOROFORM-D) δ 8.27 (d, J = 0.7 1-(2-chlorophenyl)-N-(2-(1- Hz, 1H), 7.97 (d, J = 0.5 Hz, 1H), 7.78 (d, J = 3.4 Hz, 1H), 61 methyl-1H-pyrazol-4-yl)-2- 7.61 (t, J = 6.0 Hz, 1H), 7.58-7.52 (m, 2H), 7.43-7.36 (m, (thiazol-2-yl)propyl)-1H- 3H), 7.32 (d, J = 0.5 Hz, 1H), 7.29 (d, J = 3.4 Hz, 1H), 4.01 pyrazole-4-carboxamide (d, J = 5.9 Hz, 2H), 3.88 (s, 3H), 1.83 (s, 3H); LCMS (M / Z): 426.9 N-(2-(4-bromothiazol-2-yl)-2-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.31-8.30 (m, 62 (1-methyl-1H-pyrazol-4- 1H), 8.00 (s, 1H), 7.73-7.69 (m, 1H), 7.48-7.44 (m, 2H), 7.36 yl)propyl)-1-(2-fluoro-4- (s, 1H), 7.17 (s, 1H), 6.82-6.77 (m, 2H), 4.03 (q, J = 6.8 Hz, methoxyphenyl)-1H-pyrazole-4- 1H), 3.94 (dd, J = 13.4, 4.9 Hz, 1H), 3.89 (d, J = 3.9 Hz, 3H), carboxamide 3.85 (d, J = 2.0 Hz, 3H), 1.79 (s, 3H); LCMS (M / Z): 520.85 PI External 1H-NMR (400 MHz, CHLOROFORM-D) δ 8.46 (d, J = 0.5 N-(2-(4-bromothiazol-2-yl)-2- Hz, 1H), 8.05 (s, 1H), 7.88 (dt, J = 9.0, 2.1 Hz, 2H), 7.78 (qd, 63 (1-methyl-1H-pyrazol-4- J = 4.4, 2.1 Hz, 2H), 7.72-7.69 (m, 1H), 7.44 (d, J = 1.0 Hz, yl)propyl)-1-(4-cyanophenyl)- 1H), 7.35 (d, J = 0.5 Hz, 1H), 7.19 (s, 1H), 4.02 (q, J = 6.8 1H-pyrazole-4-carboxamide Hz, 1H), 3.95-3.92 (m, 1H), 3.90 (s, 3H), 1.79 (s, 3H); LCMS (M / Z): 497.85 1 N-(2-(4-bromothiazol-2-yl)-2- H-NMR (400 MHz, CHLOROFORM-D) δ 8.37 (d, J = 0.5 Hz, 1H), 8.01 (d, J = 0.5 Hz, 1H), 7.91 (q, J = 1.0 Hz, 1H), 64 (1-methyl-1H-pyrazol-4- yl)propyl)-1-(3,4- 7.68-7.65 (m, 1H), 7.59-7.53 (m, 2H), 7.44 (d, J = 0.7 Hz, dichlorophenyl)-1H-pyrazole-4- 1H), 7.36 (d, J = 0.5 Hz, 1H), 7.18 (s, 1H), 4.02 (q, J = 6.8 carboxamide Hz, 1H), 3.94-3.91 (m, 1H), 3.90 (s, 3H), 1.79 (s, 3H); LCMS (M / Z): 540.85 1 1-(2,4-difluorophenyl)-N-(2-(1- H-NMR (400 MHz, CHLOROFORM-D) δ 7.82 (s, 1H), 65 methyl-1H-pyrazol-4-yl)-2- 7.72-7.63 (m, 2H), 7.46 (dd, J = 14.3, 8.4 Hz, 1H), 7.33 (s, (thiazol-2-yl)propyl)-1H- 1H), 7.27-7.17 (m, 2H), 6.97-6.87 (m, 2H), 6.71 (s, 1H), pyrazole-3-carboxamide 3.95-3.86 (m, 2H), 3.83 (d, J = 9.0 Hz, 3H), 1.74 (s, 3H); LCMS (M / Z): 429.05 1H-NMR (400 MHz, CHLOROFORM-D) δ 8.39 (s, 1H), 1-(3-cyanophenyl)-N-(2-(1- 8.07 (t, J = 1.3 Hz, 1H), 7.97 (s, 1H), 7.93 (td, J = 4.7, 2.4 methyl-1H-pyrazol-4-yl)-2- Hz, 1H), 7.80 (d, J = 3.4 Hz, 1H), 7.74 (t, J = 5.9 Hz, 1H), 66 (thiazol-2-yl)propyl)-1H- 7.64-7.58 (m, 2H), 7.41 (d, J = 1.0 Hz, 1H), 7.32-7.30 (m, pyrazole-4-carboxamide 2H), 4.06-3.96 (m, 2H), 3.88 (s, 3H), 1.82 (s, 3H); LCMS (M / Z): 417.95 1 1-(3,4-dichlorophenyl)-N-(2-(1- H-NMR (400 MHz, CHLOROFORM-D) δ 8.32 (s, 1H), 67 methyl-1H-pyrazol-4-yl)-2- 7.94 (s, 1H), 7.88 (q, J = 1.0 Hz, 1H), 7.79 (d, J = 3.4 Hz, (thiazol-2-yl)propyl)-1H- 1H), 7.68 (t, J = 5.9 Hz, 1H), 7.54 (t, J = 1.0 Hz, 2H), 7.41 pyrazole-4-carboxamide (d, J = 0.7 Hz, 1H), 7.30 (t, J = 2.9 Hz, 2H), 4.00 (q, J = 2.9 Hz, 2H), 3.88 (s, 3H), 1.81 (s, 3H); LCMS (M / Z): 460.95 1H-NMR (400 MHz, CHLOROFORM-D) δ 8.35 (d, J = 0.5 N-(2-(1-methyl-1H-pyrazol-4- Hz, 1H), 7.94 (s, 1H), 7.81-7.78 (m, 1H), 7.71-7.68 (m, 2H), 68 yl)-2-(thiazol-2-yl)propyl)-1- 7.60 (t, J = 5.6 Hz, 1H), 7.50-7.45 (m, 2H), 7.42 (d, J = 0.7 phenyl-1H-pyrazole-4- Hz, 1H), 7.37-7.32 (m, 1H), 7.32 (s, 1H), 7.29 (d, J = 3.4 Hz, carboxamide 1H), 4.02-4.00 (m, 2H), 3.88 (s, 3H), 1.82 (s, 3H); LCMS (M / Z): 392.95 1 2-(2,4-difluorophenyl)-N-(2-(1- H-NMR (400 MHz, CHLOROFORM-D) δ 8.27 (s, 1H), 69 methyl-1H-pyrazol-4-yl)-2- 8.00 (t, J = 6.1 Hz, 1H), 7.84-7.76 (m, 2H), 7.42 (d, J = 0.7 (thiazol-2-yl)propyl)-2H-1,2,3- Hz, 1H), 7.32 (s, 1H), 7.27 (d, J = 3.4 Hz, 1H), 7.09-7.01 (m, triazole-4-carboxamide 2H), 4.07 (dd, J = 6.4, 2.2 Hz, 2H), 3.87 (s, 3H), 1.83 (s, 3H); LCMS (M / Z): 430.2 1-(2-chloro-6-fluorophenyl)-N-1(2-(4-chloro H-NMR (400 MHz, CHLOROFORM-D) δ 8.06 (s, 2H), 70 thiazol-2-yl)-2-(1- methyl-1H-pyrazol-4- 7.45-7.35 (m, 5H), 7.22-7.18 (m, 1H), 7.03 (s, 1H), 4.04 (q, yl)propyl)-1H-pyrazole-4- J = 6.8 Hz, 1H), 3.95 (dd, J = 13.4, 4.9 Hz, 1H), 3.90 (s, 3H), carboxamide 1.80 (s, 3H); LCMS (M / Z): 478.85 N-(2-(4-bromothiazol-2-yl)-2-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.08 (d, J = 3.1 71 (1-methyl-1H-pyrazol-4- Hz, 2H), 7.52-7.50 (m, 1H), 7.45 (d, J = 0.9 Hz, 1H), 7.35 (s, yl)propyl)-1-(2,4,6- 1H), 7.17 (d, J = 3.4 Hz, 1H), 6.91-6.85 (m, 2H), 4.07-4.01 trifluorophenyl)-1H-pyrazole-4- (m, 1H), 3.96-3.92 (m, 1H), 3.90 (s, 3H), 1.79 (s, 3H); LCMS carboxamide (M / Z): 526.85 1-(2,5-difluorophenyl)-N-(2-(1-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.47 (d, J = 1.7 72 methyl-1H-pyrazol-4-yl)-2- Hz, 1H), 7.99 (s, 1H), 7.80 (d, J = 3.4 Hz, 1H), 7.78 (d, J = (thiazol-2-yl)propyl)-1H- 6.1 Hz, 1H), 7.71-7.67 (m, 1H), 7.44 (d, J = 0.7 Hz, 1H), 7.36 pyrazole-4-carboxamide (s, 1H), 7.32 (d, J = 3.4 Hz, 1H), 7.25-7.20 (m, 1H), 7.04- PI External 6.99 (m, 1H), 4.06 (dd, J = 13.4, 5.6 Hz, 1H), 3.98-3.97 (m, 1H), 3.90 (s, 3H), 1.83 (s, 3H); LCMS (M / Z): 429 1 N-(2-(4-bromothiazol-2-yl)-2- H-NMR (400 MHz, CHLOROFORM-D) δ 8.50 (d, J = 2.0 (1-methyl-1H Hz, 1H), 8.04 (s, 1H), 7.74-7.70 (m, 1H), 7.58 (t, J = 5.7 Hz, 73 -pyrazol-4- yl)propyl)-1-(2,5- 1H), 7.44 (d, J = 1.0 Hz, 1H), 7.36 (d, J = 0.5 Hz, 1H), 7.25- difluorophenyl)-1H-pyrazole-4- 7.20 (m, 1H), 7.17 (s, 1H), 7.04-6.99 (m, 1H), 4.03 (q, J = carboxamide 6.8 Hz, 1H), 3.94 (dd, J = 13.4, 4.9 Hz, 1H), 3.90 (s, 3H), 1.79 (s, 3H); LCMS (M / Z): 508.55 1H-NMR (400 MHz, CHLOROFORM-D) δ 8.47 (d, J = 2.0 N-(2-(4-bromothiazol-2-yl)-2- Hz, 1H), 8.04 (s, 1H), 7.99 (dd, J = 6.8, 2.4 Hz, 1H), 7.58 (t, 74 (1-methyl-1H-pyrazol-4- J = 5.7 Hz, 1H), 7.44 (d, J = 0.7 Hz, 1H), 7.36 (d, J = 0.5 Hz, yl)propyl)-1-(5-chloro-2- 1H), 7.28 (qd, J = 4.4, 2.6 Hz, 1H), 7.21 (dd, J = 10.9, 8.9 fluorophenyl)-1H-pyrazole-4- Hz, 1H), 7.18 (s, 1H), 4.03 (q, J = 6.8 Hz, 1H), 3.93 (dd, J = carboxamide 13.4, 4.9 Hz, 1H), 3.90 (s, 3H), 1.79 (s, 3H); LCMS (M / Z): 524.65 1 1-(2,6-difluorophenyl)-N-(2-(1- H-NMR (400 MHz, DMSO-D6) δ 8.55 (s, 1H), 8.16 (s, 1H), 75 methyl-1H-pyrazol-4-yl)-2- 8.02 (t, J = 6.4 Hz, 1H), 7.75 (d, J = 3.4 Hz, 1H), 7.69 (s, 1H), (thiazol-2-yl)propyl)-1H- 7.66-7.59 (m, 1H), 7.57 (d, J = 3.2 Hz, 1H), 7.42-7.36 (m, pyrazole-4-carboxamide 3H), 3.91 (ddd, J = 24.5, 13.2, 6.4 Hz, 2H), 3.78 (s, 3H), 1.71 (s, 3H); LCMS (M / Z): 429.1 N-(2-(4-chlorothiazol-2-yl)-2-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.07 (s, 1H), (1-methyl-1H-pyrazol-4- 8.06 (s, 1H), 7.45-7.41 (m, 2H), 7.36 (s, 1H), 7.03 (s, 1H), 76 yl)propyl)-1-(2,4,6- 6.90-6.85 (m, 2H), 4.03 (q, J = 6.8 Hz, 1H), 3.94 (dd, J = trifluorophenyl)-1H-pyrazole-4- 13.4, 5.1 Hz, 1H), 3.90 (s, 3H), 1.79 (s, 3H); LCMS (M / Z): carboxamide 480.95 1 2-(5-chloro-2-fluorophenyl)-N- H-NMR (400 MHz, CHLOROFORM-D) δ 8.64 (t, J = 5.9 77 (2-(1-methyl-1H-pyrazol-4-yl)- Hz, 1H), 7.96 (dd, J = 6.0, 2.6 Hz, 1H), 7.80 (t, J = 3.2 Hz, 2-(thiazol-2-yl)propyl)-2H- 1H), 7.55-7.50 (m, 1H), 7.41 (d, J = 2.4 Hz, 1H), 7.36-7.32 tetrazole-5-carboxamide (m, 2H), 7.29 (t, J = 3.1 Hz, 1H), 4.19-4.09 (m, 2H), 3.87 (s, 3H), 1.85 (s, 3H); LCMS (M / Z): 447.05 N-(2-(4-bromothiazol-2-yl)-2-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.31 (d, J = 0.6 78 (1-methyl-1H-pyrazol-4- Hz, 1H), 8.03 (s, 1H), 7.57-7.52 (m, 3H), 7.45 (d, J = 0.6 Hz, yl)propyl)-1-(2,4- 1H), 7.39 (dt, J = 8.6, 2.1 Hz, 1H), 7.36 (s, 1H), 7.17 (s, 1H), dichlorophenyl)-1H-pyrazole-4- 4.07-4.01 (m, 1H), 3.93 (dd, J = 13.3, 4.7 Hz, 1H), 3.90 (s, carboxamide 3H), 1.79 (s, 3H); LCMS (M / Z): 540.75 1 N-(2-(4-bromothiazol-2-yl)-2- H-NMR (400 MHz, CHLOROFORM-D) δ 8.44 (d, J = 2.4 (1-methyl-1H-pyraz Hz, 1H), 8.05 (s, 1H), 7.83-7.79 (m, 1H), 7.57-7.54 (m, 1H), 79 ol-4- yl)propyl)-1-(3-chloro-2- 7.44 (d, J = 3.7 Hz, 1H), 7.40 (tt, J = 6.3, 1.9 Hz, 1H), 7.36 fluorophenyl)-1H-pyrazole-4- (s, 1H), 7.24-7.20 (m, 1H), 7.17 (s, 1H), 4.07-4.01 (m, 1H), carboxamide 3.94 (dd, J = 13.4, 4.9 Hz, 1H), 3.90 (d, J = 3.1 Hz, 3H), 1.80 (d, J = 4.0 Hz, 3H); LCMS (M / Z): 524.75 N-(2-(4-bromothiazol-2-yl)-2-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.29 (d, J = 0.6 80 (1-methyl-1H-pyrazol-4- Hz, 1H), 7.97 (s, 1H), 7.63-7.59 (m, 2H), 7.52-7.49 (m, 1H), yl)propyl)-1-(4- 7.45 (d, J = 0.9 Hz, 1H), 7.36 (s, 1H), 7.17 (s, 1H), 7.01-6.97 methoxyphenyl)-1H-pyrazole-4- (m, 2H), 4.06-4.01 (m, 1H), 3.93 (dd, J = 13.4, 4.9 Hz, 1H), carboxamide 3.90 (s, 3H), 3.85 (s, 3H), 1.79 (s, 3H); LCMS (M / Z): 502.8 N-(2-(4-bromothiazol-2-yl)-2-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.46 (s, 1H), 81 (1-methyl-1H-pyrazol-4- 8.04 (s, 1H), 7.87 (d, J = 8.6 Hz, 2H), 7.75 (d, J = 8.6 Hz, yl)propyl)-1-(4- 2H), 7.68-7.65 (m, 1H), 7.45 (d, J = 0.9 Hz, 1H), 7.36 (s, 1H), (trifluoromethyl)phenyl)-1H- 7.19 (s, 1H), 4.03 (q, J = 6.8 Hz, 1H), 3.93 (dd, J = 13.4, 4.6 pyrazole-4-carboxamide Hz, 1H), 3.90 (s, 3H), 1.79 (s, 3H); LCMS (M / Z): 540.75 1 82 N-(2-(4-bromothiazol-2-yl)-2- H-NMR (400 MHz, CHLOROFORM-D) δ 8.40 (s, 1H), (1-methyl-1H-pyrazol-4- 8.03 (s, 1H), 7.56-7.49 (m, 2H), 7.46 (d, J = 10.1 Hz, 1H), yl)propyl)-1-(2-chloro-5- 7.41 (dd, J = 8.7, 2.9 Hz, 1H), 7.36 (s, 1H), 7.17 (s, 1H), 7.14- PI External fluorophenyl)-1H-pyrazole-4- 7.08 (m, 1H), 4.07-4.01 (m, 1H), 3.94 (dd, J = 13.4, 4.9 Hz, carboxamide 1H), 3.91-3.86 (m, 3H), 1.79 (s, 3H); LCMS (M / Z): 524.85 1H-NMR (400 MHz, CHLOROFORM-D) δ 8.43 (s, 1H), N-(2-(4-bromothiazol-2-yl)-2- 8.09 (t, J = 1.2 Hz, 1H), 8.04 (s, 1H), 7.96 (td, J = 4.6, 2.3 83 (1-methyl-1H-pyrazol-4- Hz, 1H), 7.68 (t, J = 5.7 Hz, 1H), 7.65-7.59 (m, 2H), 7.45 (d, yl)propyl)-1-(3-cyanophenyl)- J = 0.6 Hz, 1H), 7.36 (s, 1H), 7.19 (s, 1H), 4.02 (q, J = 6.8 1H-pyrazole-4-carboxamide Hz, 1H), 3.95-3.92 (m, 1H), 3.90 (s, 3H), 1.79 (s, 3H); LCMS (M / Z): 497.75 1H-NMR (400 MHz, CHLOROFORM-D) δ 8.39 (s, 1H), N-(2-(4-bromothiazol-2-yl)-2- 8.01 (s, 1H), 7.80 (t, J = 2.0 Hz, 1H), 7.64-7.59 (m, 2H), 7.45 84 (1-methyl-1H-pyrazol-4- (d, J = 0.6 Hz, 1H), 7.41 (t, J = 8.1 Hz, 1H), 7.36 (s, 1H), 7.32 yl)propyl)-1-(3-chlorophenyl)- (dq, J = 8.1, 1.0 Hz, 1H), 7.18 (s, 1H), 4.02 (q, J = 6.8 Hz, 1H-pyrazole-4-carboxamide 1H), 3.95-3.92 (m, 1H), 3.90 (s, 3H), 1.79 (s, 3H); LCMS (M / Z): 506.9 1H-NMR (400 MHz, CHLOROFORM-D) δ 8.36 (s, 1H), 1-(2-chloro-5-fluorophenyl)-N- 7.98 (s, 1H), 7.78 (d, J = 3.4 Hz, 1H), 7.67 (t, J = 5.5 Hz, 1H), 85 (2-(1-methyl-1H-pyrazol-4-yl)- 7.50 (dd, J = 9.0, 5.3 Hz, 1H), 7.41 (d, J = 0.6 Hz, 1H), 7.38 2-(thiazol-2-yl)propyl)-1H- (dd, J = 8.6, 3.1 Hz, 1H), 7.32 (s, 1H), 7.29 (d, J = 3.4 Hz, pyrazole-4-carboxamide 1H), 7.13-7.08 (m, 1H), 4.00 (d, J = 5.8 Hz, 2H), 3.87 (s, 3H), 1.82 (s, 3H); LCMS (M / Z): 445 1 1-(3-chlorophenyl)-N-(2-(1- H-NMR (400 MHz, CHLOROFORM-D) δ 8.35 (d, J = 0.7 methyl-1H- Hz, 1H), 7.94 (s, 1H), 7.79 (d, J = 3.4 Hz, 1H), 7.76 (t, J = 86 pyrazol-4-yl)-2- (thiazol-2-yl)propyl)-1H- 2.0 Hz, 1H), 7.65 (t, J = 5.7 Hz, 1H), 7.57 (dq, J = 8.1, 1.1 pyrazole-4-carboxamide Hz, 1H), 7.42-7.38 (m, 2H), 7.33-7.29 (m, 3H), 4.05-3.96 (m, 2H), 3.87 (s, 3H), 1.81 (s, 3H); LCMS (M / Z): 427.15 1-(4-cyanophenyl)-N-(2-(1-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.43 (s, 1H), 87 methyl-1H-pyrazol-4-yl)-2- 7.98 (s, 1H), 7.87-7.83 (m, 2H), 7.79-7.74 (m, 4H), 7.40 (s, (thiazol-2-yl)propyl)-1H- 1H), 7.31-7.30 (m, 2H), 4.02-3.99 (m, 2H), 3.87 (s, 3H), 1.81 pyrazole-4-carboxamide (s, 3H); LCMS (M / Z): 417.8 1H-NMR (400 MHz, CHLOROFORM-D) δ 8.26 (dd, J = 1-(2-fluoro-4-methoxyphenyl)- 2.3, 0.6 Hz, 1H), 7.94 (s, 1H), 7.77 (d, J = 3.2 Hz, 1H), 7.71- 88 N-(2-(1-methyl-1H-pyrazol-4- 7.66 (m, 1H), 7.57 (t, J = 5.7 Hz, 1H), 7.41 (d, J = 0.7 Hz, yl)-2-(thiazol-2-yl)propyl)-1H- 1H), 7.32 (d, J = 0.5 Hz, 1H), 7.28 (d, J = 3.4 Hz, 1H), 6.81- pyrazole-4-carboxamide 6.76 (m, 2H), 4.02-3.99 (m, 2H), 3.87 (s, 3H), 3.84 (s, 3H), 1.81 (s, 3H); LCMS (M / Z): 441.2 1 2-(2,4-dichlorophenyl)-N-(2-(1- H-NMR (400 MHz, DMSO-D6) δ 8.92 (t, J = 6.4 Hz, 1H), 89 methyl-1H-pyrazol-4-yl)-2- 8.11 (d, J = 2.2 Hz, 1H), 7.97 (d, J = 8.8 Hz, 1H), 7.80-7.78 (thiazol-2-yl)propyl)-2H- (m, 2H), 7.73 (s, 1H), 7.61 (d, J = 3.4 Hz, 1H), 7.45 (d, J = tetrazole-5-carboxamide 0.7 Hz, 1H), 4.06 (dd, J = 13.3, 6.2 Hz, 1H), 3.94 (q, J = 6.7 Hz, 1H), 3.79 (s, 3H), 1.74 (s, 3H); LCMS (M / Z): 463.1 N-(2-(4-chlorothiazol-2-yl)-2-1H-NMR (400 MHz, DMSO-D6) δ 9.00 (t, J = 6.4 Hz, 1H), 90 (1-methyl-1H-pyrazol-4- 8.11 (d, J = 2.2 Hz, 1H), 7.98-7.94 (m, 1H), 7.80-7.77 (m, yl)propyl)-2-(2,4- 2H), 7.61 (s, 1H), 7.51 (d, J = 0.7 Hz, 1H), 4.04 (q, J = 6.5 dichlorophenyl)-2H-tetrazole-5- Hz, 1H), 3.89 (q, J = 6.7 Hz, 1H), 3.81 (s, 3H), 1.71 (s, 3H); carboxamide LCMS (M / Z): 499 1H-NMR (400 MHz, CHLOROFORM-D) δ 8.48 (d, J = 5.6 1-(4-fluorophenyl)-N-(2-(1- Hz, 1H), 8.28 (t, J = 6.1 Hz, 1H), 7.80 (d, J = 3.2 Hz, 1H), 91 methyl-1H-pyrazol-4-yl)-2- 7.73-7.68 (m, 2H), 7.42 (d, J = 0.7 Hz, 1H), 7.35 (d, J = 0.7 (thiazol-2-yl)propyl)-1H-1,2,4- Hz, 1H), 7.27 (d, J = 3.4 Hz, 1H), 7.24-7.18 (m, 2H), 4.11 triazole-3-carboxamide (dd, J = 6.4, 2.4 Hz, 2H), 3.86 (s, 3H), 1.84 (s, 3H); LCMS (M / Z): 411.85 1 92 1-(2,3-difluorophenyl)-N-(2-(1- H-NMR (400 MHz, CHLOROFORM-D) δ 8.41 (d, J = 2.2 methyl-1H-pyrazol-4-yl)-2- Hz, 1H), 8.00 (s, 1H), 7.79-7.76 (m, 1H), 7.71-7.65 (m, 2H), 7.41 (d, J = 0.7 Hz, 1H), 7.32 (s, 1H), 7.29 (d, J = 3.4 Hz, PI External (thiazol-2-yl)propyl)-1H- 1H), 7.24-7.14 (m, 2H), 4.05-3.96 (m, 2H), 3.89 (d, J = 8.1 pyrazole-4-carboxamide Hz, 3H), 1.82 (s, 3H); LCMS (M / Z): 429.15 1 1-(4-chlorophenyl)-N-(2-(1- H-NMR (400 MHz, CHLOROFORM-D) δ 7.91 (t, J = 6.2 93 methyl-1H-pyrazol-4-yl)-2- Hz, 1H), 7.88 (d, J = 2.4 Hz, 1H), 7.79 (d, J = 3.2 Hz, 1H), (thiazol-2-yl)propyl)-1H- 7.64-7.59 (m, 2H), 7.46-7.42 (m, 3H), 7.34 (s, 1H), 7.27 (d, pyrazole-3-carboxamide J = 3.2 Hz, 1H), 6.99-6.97 (m, 1H), 4.10-4.04 (m, 2H), 3.86 (s, 3H), 1.84 (s, 3H); LCMS (M / Z): 427.7 N-(2-(4-chlorothiazol-2-yl)-2-1H-NMR (400 MHz, DMSO-D6) δ 8.92 (t, J = 6.4 Hz, 1H), 94 (1-methyl-1H-pyrazol-4- 7.87 (t, J = 8.7 Hz, 1H), 7.80 (s, 1H), 7.60 (s, 1H), 7.51 (d, J yl)propyl)-2-(2-fluoro-4- = 0.7 Hz, 1H), 7.28 (dd, J = 12.7, 2.7 Hz, 1H), 7.06 (dt, J = methoxyphenyl)-2H-tetrazole-5- 9.0, 1.3 Hz, 1H), 4.07-3.98 (m, 1H), 3.91-3.86 (m, 4H), 3.77 carboxamide (d, J = 28.6 Hz, 3H), 1.71 (s, 3H); LCMS (M / Z): 477.2 N-(2-(4-chlorothiazol-2-yl)-2-1H-NMR (400 MHz, DMSO-D6) δ 8.87 (t, J = 6.4 Hz, 1H), 95 (1-methyl-1H-pyrazol-4- 8.05-8.00 (m, 2H), 7.80 (s, 1H), 7.61 (s, 1H), 7.51 (d, J = 0.7 yl)propyl)-2-(4- Hz, 1H), 7.23-7.19 (m, 2H), 4.04 (q, J = 6.5 Hz, 1H), 3.88 (q, methoxyphenyl)-2H-tetrazole-5- J = 6.8 Hz, 4H), 3.81 (s, 3H), 1.71 (s, 3H); LCMS (M / Z): carboxamide 459.10 1H-NMR (400 MHz, DMSO-D6) δ 8.98 (t, J = 6.4 Hz, 1H), 2-(2-chlorophenyl)-N-(2-(4- 7.91 (dd, J = 7.9, 1.6 Hz, 1H), 7.86 (dd, J = 8.2, 1.3 Hz, 1H), 96 chlorothiazol-2-yl)-2-(1-methyl- 7.81 (s, 1H), 7.76 (td, J = 7.8, 1.7 Hz, 1H), 7.69-7.63 (m, 1H), 1H-pyrazol-4-yl)propyl)-2H- 7.59 (d, J = 11.5 Hz, 1H), 7.52 (d, J = 0.7 Hz, 1H), 4.07-3.98 tetrazole-5-carboxamide (m, 1H), 3.89 (q, J = 6.6 Hz, 1H), 3.81 (s, 3H), 1.72 (s, 3H); LCMS (M / Z): 463 N-(2-(4-chlorothiazol-2-yl)-2-1H-NMR (400 MHz, DMSO-D6) δ 8.95 (t, J = 6.5 Hz, 1H), 97 (1-methyl-1H-pyrazol-4- 7.80 (s, 1H), 7.79-7.75 (m, 1H), 7.66-7.62 (m, 1H), 7.61 (s, yl)propyl)-2-(2-fluoro-3- 1H), 7.51 (d, J = 0.7 Hz, 1H), 7.40 (t, J = 7.9 Hz, 1H), 4.05 methylphenyl)-2H-tetrazole-5- (q, J = 6.6 Hz, 1H), 3.89 (q, J = 6.5 Hz, 1H), 3.81 (s, 3H), carboxamide 2.37 (d, J = 2.2 Hz, 3H), 1.71 (s, 3H); LCMS (M / Z): 461.1 1H-NMR (400 MHz, DMSO-D6) δ 9.00 (s, 1H), 8.14 (s, 1H), 1-(3-chlorophenyl)-N-(2-(4- 8.04 (t, J = 6.4 Hz, 1H), 7.93 (t, J = 2.0 Hz, 1H), 7.84-7.82 98 chlorothiazol-2-yl)-2-(1-methyl- (m, 1H), 7.76 (s, 1H), 7.58 (s, 1H), 7.54 (t, J = 8.2 Hz, 1H), 1H-pyrazol-4-yl)propyl)-1H- 7.48 (d, J = 0.7 Hz, 1H), 7.43-7.40 (m, 1H), 3.94 (q, J = 6.6 pyrazole-4-carboxamide Hz, 1H), 3.86-3.80 (m, 4H), 1.70 (s, 3H); LCMS (M / Z): 461.1 1H-NMR (400 MHz, CHLOROFORM-D) δ 8.26 (d, J = 0.6 1-(2,4-dichlorophenyl)-N-(2-(1- Hz, 1H), 7.97 (d, J = 0.6 Hz, 1H), 7.77 (d, J = 3.4 Hz, 1H), 99 methyl-1H-pyrazol-4-yl)-2- 7.65 (t, J = 5.8 Hz, 1H), 7.57-7.55 (m, 1H), 7.53-7.51 (m, (thiazol-2-yl)propyl)-1H- 1H), 7.41 (d, J = 0.6 Hz, 1H), 7.38 (dd, J = 8.6, 2.1 Hz, 1H), pyrazole-4-carboxamide 7.32 (s, 1H), 7.29 (t, J = 3.2 Hz, 1H), 4.00 (d, J = 5.8 Hz, 2H), 3.87 (s, 3H), 1.82 (s, 3H); LCMS (M / Z): 461.05 1 1-(3-chloro-2-fluorophenyl)-N- H-NMR (400 MHz, CHLOROFORM-D) δ 8.40-8.39 (m, 100 (2-(1-methyl-1H-pyrazol-4-yl)- 1H), 8.00 (s, 1H), 7.82-7.77 (m, 2H), 7.66 (t, J = 5.7 Hz, 1H), 2-(thiazol-2-yl)propyl)-1H- 7.42-7.38 (m, 2H), 7.32 (d, J = 0.6 Hz, 1H), 7.29 (d, J = 3.4 pyrazole-4-carboxamide Hz, 1H), 7.22 (td, J = 8.2, 1.6 Hz, 1H), 4.03-3.96 (m, 2H), 3.87 (s, 3H), 1.81 (s, 3H); LCMS (M / Z): 445.05 1 1-(4-methoxyphenyl)-N-(2-(1- H-NMR (400 MHz, CHLOROFORM-D) δ 8.25 (s, 1H), 101 methyl-1H-pyrazol-4-yl)-2- 7.90 (s, 1H), 7.78 (d, J = 3.4 Hz, 1H), 7.60-7.54 (m, 3H), 7.41 (thiazol-2-yl)propyl)-1H- (s, 1H), 7.31 (s, 1H), 7.28 (d, J = 3.4 Hz, 1H), 7.00-6.96 (m, pyrazole-4-carboxamide 2H), 4.01 (d, J = 6.1 Hz, 2H), 3.86 (d, J = 9.8 Hz, 6H), 1.81 (s, 3H); LCMS (M / Z): 423.05 N-(2-(1-methyl-1H-pyrazol-4-1102 yl)-2-(thiazol-2-yl)propyl)-1-(4- H-NMR (400 MHz, CHLOROFORM-D) δ 8.42 (s, 1H), (trifluoromethyl)phenyl)-1H- 7.97 (s, 1H), 7.84 (d, J = 8.6 Hz, 2H), 7.79 (d, J = 3.4 Hz, pyrazole-4-carboxamide 1H), 7.76-7.70 (m, 3H), 7.41 (d, J = 0.6 Hz, 1H), 7.31 (s, 1H), PI External 7.30 (d, J = 3.4 Hz, 1H), 4.05-3.96 (m, 2H), 3.87 (s, 3H), 1.81 (s, 3H); LCMS (M / Z): 461.2 1H-NMR (400 MHz, DMSO-D6) δ 8.88 (t, J = 6.4 Hz, 1H), 2-(2-fluoro-3-methylphenyl)-N- 7.79-7.75 (m, 2H), 7.73 (s, 1H), 7.65 (d, J = 6.8 Hz, 1H), 7.61 103 (2-(1-methyl-1H-pyrazol-4-yl)- (d, J = 3.2 Hz, 1H), 7.45 (d, J = 0.7 Hz, 1H), 7.40 (t, J = 7.8 2-(thiazol-2-yl)propyl)-2H- Hz, 1H), 4.06 (dd, J = 13.3, 6.2 Hz, 1H), 3.94 (q, J = 6.6 Hz, tetrazole-5-carboxamide 1H), 3.79 (s, 3H), 2.38 (d, J = 2.0 Hz, 3H), 1.74 (s, 3H); LCMS (M / Z): 427.2 1H-NMR (400 MHz, DMSO-D6) δ 8.91 (t, J = 6.2 Hz, 1H), 2-(2-chlorophenyl)-N-(2-(1- 7.91 (dd, J = 7.8, 1.7 Hz, 1H), 7.87 (dd, J = 8.1, 1.5 Hz, 1H), 104 methyl-1H-pyrazol-4-yl)-2- 7.81-7.74 (m, 2H), 7.73 (s, 1H), 7.67 (td, J = 7.7, 1.3 Hz, 1H), (thiazol-2-yl)propyl)-2H- 7.61 (d, J = 3.4 Hz, 1H), 7.45 (d, J = 0.5 Hz, 1H), 4.06 (dd, J tetrazole-5-carboxamide = 13.2, 6.1 Hz, 1H), 3.94 (q, J = 6.6 Hz, 1H), 3.79 (s, 3H), 1.75 (s, 3H); LCMS (M / Z): 429.15 1 2-(4-methoxyphenyl)-N-(2-(1- H-NMR (400 MHz, DMSO-D6) δ 8.81 (t, J = 6.2 Hz, 1H), 105 methyl-1H-pyrazol-4-yl)-2- 8.03-8.00 (m, 2H), 7.80 (d, J = 3.4 Hz, 1H), 7.73 (s, 1H), 7.62 (thiazol-2-yl)propyl)-2H- (d, J = 3.4 Hz, 1H), 7.44 (s, 1H), 7.22-7.19 (m, 2H), 4.05 (dd, tetrazole-5-carboxamide J = 13.2, 6.1 Hz, 1H), 3.93 (q, J = 6.6 Hz, 1H), 3.86 (s, 3H), 3.79 (s, 3H), 1.74 (s, 3H); LCMS (M / Z): 425.05 1H-NMR (400 MHz, DMSO-D6) δ 8.86 (t, J = 6.4 Hz, 1H), 2-(2-fluoro-4-methoxyphenyl)- 7.87 (t, J = 8.8 Hz, 1H), 7.78 (d, J = 3.2 Hz, 1H), 7.73 (s, 1H), 106 N-(2-(1-methyl-1H-pyrazol-4- 7.61 (d, J = 3.4 Hz, 1H), 7.44 (s, 1H), 7.28 (dd, J = 12.6, 2.6 yl)-2-(thiazol-2-yl)propyl)-2H- Hz, 1H), 7.06 (dt, J = 9.0, 1.3 Hz, 1H), 4.06 (dd, J = 13.3, 6.2 tetrazole-5-carboxamide Hz, 1H), 3.93 (q, J = 6.6 Hz, 1H), 3.88 (s, 3H), 3.79 (s, 3H), 1.74 (s, 3H); LCMS (M / Z): 443 1 N-(2-(4-chlorothiazol-2-yl)-2- H-NMR (400 MHz, DMSO-D6) δ 8.10 (t, J = 1.6 Hz, 1H), 107 (1-methyl-1H-pyrazol-4- 8.05 (t, J = 1.5 Hz, 1H), 7.80 (d, J = 0.5 Hz, 1H), 7.76-7.68 yl)propyl)-1-(2-fluorophenyl)- (m, 2H), 7.61 (s, 1H), 7.52-7.48 (m, 3H), 7.39-7.35 (m, 1H), 1H-imidazole-4-carboxamide 3.99 (q, J = 6.7 Hz, 1H), 3.86-3.82 (m, 4H), 1.66 (s, 3H); LCMS (M / Z): 445.45 N-(2-(4-chlorothiazol-2-yl)-2-1H-NMR (400 MHz, DMSO-D6) δ 8.27 (d, J = 1.5 Hz, 1H), 108 (1-methyl-1H-pyrazol-4- 8.24 (d, J = 1.5 Hz, 1H), 7.79-7.71 (m, 4H), 7.61 (s, 1H), 7.50 yl)propyl)-1-(4-fluorophenyl)- (d, J = 0.7 Hz, 1H), 7.41-7.35 (m, 2H), 3.99 (q, J = 6.7 Hz, 1H-imidazole-4-carboxamide 1H), 3.86-3.82 (m, 4H), 1.66 (s, 3H); LCMS (M / Z): 444.65 1 2-(4-chlorophenyl)-N-(2-(4- H-NMR (400 MHz, DMSO-D6) δ 8.93 (t, J = 6.4 Hz, 1H), 109 chlorothiazol-2-yl)-2-(1-methyl- 8.13 (dt, J = 9.5, 2.6 Hz, 2H), 7.80 (s, 1H), 7.78-7.75 (m, 2H), 1H-pyrazol-4-yl)propyl)-2H- 7.61 (s, 1H), 7.51 (d, J = 0.5 Hz, 1H), 4.04 (q, J = 6.6 Hz, tetrazole-5-carboxamide 1H), 3.89 (q, J = 6.6 Hz, 1H), 3.81 (s, 3H), 1.72 (s, 3H); LCMS (M / Z): 462.95 N-(2-(4-chlorothiazol-2-yl)-2-1H-NMR (400 MHz, DMSO-D6) δ 8.86 (t, J = 6.4 Hz, 1H), 110 (1-methyl-1H-pyrazol-4- 8.01-7.97 (m, 2H), 7.80 (s, 1H), 7.61 (s, 1H), 7.51 (d, J = 0.7 yl)propyl)-2-(4- Hz, 1H), 7.20-7.16 (m, 2H), 4.77-4.71 (m, 1H), 4.04 (q, J = isopropoxyphenyl)-2H- 6.6 Hz, 1H), 3.88 (q, J = 6.6 Hz, 1H), 3.81 (s, 3H), 1.71 (s, tetrazole-5-carboxamide 3H), 1.30 (d, J = 5.9 Hz, 6H); LCMS (M / Z): 487.05 N-(2-(4-chlorothiazol-2-yl)-2-1H-NMR (400 MHz, 11 (1-methyl-1 DMSO-D6) δ 8.06 (d, J = 1.5 Hz, 1H), 1 H-pyrazol-4- yl)propyl)-1-(2,4- 8.03 (d, J = 1.2 Hz, 1H), 7.79-7.72 (m, 3H), 7.64-7.58 (m, difluorophenyl)-1H-imidazole- 2H), 7.50 (s, 1H), 7.31-7.27 (m, 1H), 3.99 (q, J = 6.7 Hz, 1H), 4-carboxamide 3.86-3.81 (m, 4H), 1.66 (s, 3H); LCMS (M / Z): 463 1-(3,5-1H-NMR (400 MHz, DMSO-D6) δ 9.62 (s, 1H), 8.69 (s, 2H), 112 bis(trifluoromethyl)phenyl)-N- 8.42 (t, J = 6.5 Hz, 1H), 8.30 (s, 1H), 7.80 (s, 1H), 7.61 (s, (2-(4-chlorothiazol-2-yl)-2-(1- 1H), 7.51 (s, 1H), 4.02 (q, J = 6.5 Hz, 1H), 3.88 (q, J = 6.6 methyl-1H-pyrazol-4- Hz, 1H), 3.81 (s, 3H), 1.70 (s, 3H); LCMS (M / Z): 565 PI External yl)propyl)-1H-1,2,3-triazole-4- carboxamide 1-(3-chloro-5-1(trifluoromethyl)phenyl)-N-(2- H-NMR (400 MHz, DMSO-D6) δ 9.51 (s, 1H), 8.45 (s, 1H), 113 (4-chlorothiazol-2-yl)-2-(1- 8.39 (t, J = 6.6 Hz, 1H), 8.35 (s, 1H), 8.06 (s, 1H), 7.80 (s, methyl-1H-pyrazol-4- 1H), 7.61 (s, 1H), 7.51 (s, 1H), 4.02 (q, J = 6.6 Hz, 1H), 3.87 yl)propyl)-1H-1,2,3-triazole-4- (q, J = 6.7 Hz, 1H), 3.81 (s, 3H), 1.70 (s, 3H); LCMS (M / Z): carboxamide 531.95 1-(2-chloro-4-fluorophenyl)-N-1H-NMR (400 MHz, DMSO-D6) δ 8.23 (t, J = 6.4 Hz, 1H), (2-(4-chlorothiazol-2-yl)-2-(1- 7.87 (td, J = 5.7, 3.0 Hz, 2H), 7.80 (s, 1H), 7.61 (s, 1H), 7.55- 114 methyl-1H-pyrazol-4- 7.51 (m, 2H), 4.04-3.97 (m, 1H), 3.87-3.74 (m, 4H), 1.83- yl)propyl)-5-cyclopropyl-1H- 1.76 (m, 1H), 1.69 (s, 3H), 0.90-0.80 (m, 4H); LCMS (M / Z): 1,2,3-triazole-4-carboxamide 521.45 1-(2-chloro-4- (trifluoromethyl)phenyl)-N-(2-1(4-chlorothiazol-2-yl) H-NMR (400 MHz, DMSO-D6) δ 8.86 (s, 1H), 8.37 (d, J = 115 -2-(1- methyl-1H-pyrazol-4- 1.7 Hz, 1H), 8.22 (d, J = 8.1 Hz, 1H), 8.10 (dd, J = 8.4, 1.6 yl)propyl)-5-(trifluoromethyl)- Hz, 1H), 7.80 (s, 1H), 7.61 (s, 1H), 7.52 (d, J = 0.7 Hz, 1H), 1H-1,2,3-triazole-4- 4.06-3.80 (m, 5H), 1.72 (s, 3H); LCMS (M / Z): 598.95 carboxamide 1-(2-chloro-4-1(trifluoromethyl)phenyl)-N-(2- H-NMR (400 MHz, DMSO-D6) δ 8.32 (d, J = 1.5 Hz, 1H), 8.28 (t, J = 6.5 Hz, 1H), 8.05 (dd, J 16 (4-ch = 8.6, 1.7 Hz, 1H), 8.00 1 lorothiazol-2-yl)-2-(1- methyl-1H-pyrazol-4- (d, J = 8.1 Hz, 1H), 7.82 (s, 1H), 7.61 (s, 1H), 7.53 (d, J = 0.7 yl)propyl)-5-methyl-1H-1,2,3- Hz, 1H), 4.04-3.99 (m, 1H), 3.89-3.79 (m, 4H), 2.35 (d, J = triazole-4-carboxamide 11.0 Hz, 3H), 1.70 (s, 3H); LCMS (M / Z): 545.35 1 N-(2-(4-chlorothiazol-2-yl)-2- H-NMR (400 MHz, DMSO-D6) δ 8.89 (t, J = 6.3 Hz, 1H), 117 (1-methyl-1H-pyrazol-4- 8.01 (d, J = 8.6 Hz, 2H), 7.80 (s, 1H), 7.61 (s, 1H), 7.52 (d, J yl)propyl)-2-(4-ethylphenyl)- = 7.3 Hz, 3H), 4.04 (q, J = 6.6 Hz, 1H), 3.89 (q, J = 6.6 Hz, 2H-tetrazole-5-carboxamide 1H), 3.81 (s, 3H), 2.72 (q, J = 7.5 Hz, 2H), 1.71 (s, 3H), 1.22 (t, J = 7.6 Hz, 3H); LCMS (M / Z): 457.15 N-(2-(4-chlorothiazol-2-yl)-2-1H-NMR (400 MHz, DMSO-D6) δ 8.91 (t, J = 6.4 Hz, 1H), 118 (1-methyl-1H-pyrazol-4- 7.95-7.92 (m, 2H), 7.81 (s, 1H), 7.63-7.59 (m, 2H), 7.55-7.51 yl)propyl)-2-(4- (m, 2H), 4.04 (q, J = 6.6 Hz, 1H), 3.89 (q, J = 6.5 Hz, 1H), isopropylphenyl)-2H-tetrazole- 3.81 (s, 3H), 3.10-3.03 (m, 1H), 1.71 (s, 3H), 1.26 (d, J = 7.0 5-carboxamide Hz, 6H); LCMS (M / Z): 471.15 N-(2-(4-chlorothiazol-2-yl)-2-1H-NMR (400 MHz, DMSO-D6) δ 8.92 (t, J = 6.1 Hz, 1H), 119 (1-methyl-1H-pyrazol-4- 7.99 (d, J = 7.9 Hz, 2H), 7.80-7.72 (m, 2H), 7.61 (s, 1H), yl)propyl)-2-(3-fluorophenyl)- 7.55-7.51 (m, 2H), 4.07-4.01 (m, 1H), 3.90 (q, J = 6.5 Hz, 2H-tetrazole-5-carboxamide 1H), 3.81 (s, 3H), 1.72 (s, 3H); LCMS (M / Z): 447.3 N-(2-(4-chlorothiazol-2-yl)-2-1(1-methyl-1H-pyrazol-4 H-NMR (400 MHz, DMSO-D6) δ 8.22 (t, J = 6.9 Hz, 1H), 120 - yl)propyl)-1-(3,5- 7.92 (s, 1H), 7.83-7.80 (m, 3H), 7.61 (s, 1H), 7.51 (s, 1H), dichlorophenyl)-5-methyl-1H- 4.05-3.97 (m, 1H), 3.87 (t, J = 6.7 Hz, 1H), 3.81 (s, 3H), 2.52 1,2,3-triazole-4-carboxamide (s, 3H), 1.69 (s, 3H); LCMS (M / Z): 512 N-(2-(4-chlorothiazol-2-yl)-2- (1-methyl-1H-pyrazol-4-1H-NMR (400 MHz, DMSO-D6) δ 8.81 (s, 1H), 8.09 (d, J = 121 yl)propyl)-1-(2,4- 1.8 Hz, 1H), 7.98 (d, J = 8.6 Hz, 1H), 7.79-7.76 (m, 2H), 7.60 dichlorophenyl)-5- (s, 1H), 7.51 (s, 1H), 4.05-3.87 (m, 2H), 3.81 (s, 3H), 1.71 (s, (trifluoromethyl)-1H-1,2,3- 3H); LCMS (M / Z): 565.95 triazole-4-carboxamide 122 N-(2-(4-chlorothiazol-2-yl)-2-1H-NMR (400 MHz, DMSO-D6) δ 8.92 (t, J = 6.3 Hz, 1H), (1-methyl-1H-pyrazol-4- 7.93 (t, J = 7.5 Hz, 2H), 7.81 (s, 1H), 7.59 (t, J = 8.4 Hz, 2H), PI External yl)propyl)-2-(3-ethylphenyl)- 7.52-7.48 (m, 2H), 4.04 (q, J = 6.5 Hz, 1H), 3.89 (q, J = 6.6 2H-tetrazole-5-carboxamide Hz, 1H), 3.81 (s, 3H), 2.75 (q, J = 7.5 Hz, 2H), 1.72 (s, 3H), 1.23 (t, J = 7.5 Hz, 3H); LCMS (M / Z): 457.1 1 2-(3-bromophenyl)-N-(2-(4- H-NMR (400 MHz, DMSO-D6) δ 8.96 (t, J = 6.5 Hz, 1H), 123 chlorothiazol-2-yl)-2-(1-methyl- 8.29 (t, J = 2.0 Hz, 1H), 8.14 (dd, J = 7.7, 1.6 Hz, 1H), 7.86 1H-pyrazol-4-yl)propyl)-2H- (d, J = 9.0 Hz, 1H), 7.80 (s, 1H), 7.65 (t, J = 8.2 Hz, 1H), 7.61 tetrazole-5-carboxamide (s, 1H), 7.51 (s, 1H), 4.04 (q, J = 6.6 Hz, 1H), 3.89 (q, J = 6.7 Hz, 1H), 3.81 (s, 3H), 1.72 (s, 3H); LCMS (M / Z): 508.95 N-(2-(4-chlorothiazol-2-yl)-2-1H-NMR (400 MHz, DMSO-D6) δ 8.89 (t, J = 6.4 Hz, 1H), 124 (1-methyl-1H-pyrazol-4- 7.99 (d, J = 8.3 Hz, 2H), 7.80 (s, 1H), 7.61 (s, 1H), 7.51-7.48 yl)propyl)-2-(p-tolyl)-2H- (m, 3H), 4.06-4.01 (m, 1H), 3.89 (q, J = 6.6 Hz, 1H), 3.81 (s, tetrazole-5-carboxamide 3H), 2.41 (s, 3H), 1.71 (s, 3H); LCMS (M / Z): 443.4 N-(2-(4-chlorothiazol-2-yl)-2-1(1-methyl-1H-pyraz H-NMR (400 MHz, DMSO-D6) δ 8.95 (t, J = 6.3 Hz, 1H), 125 ol-4- yl)propyl)-2-(3,5- 7.91 (d, J = 5.2 Hz, 2H), 7.80 (s, 1H), 7.65-7.61 (m, 2H), 7.51 difluorophenyl)-2H-tetrazole-5- (s, 1H), 4.04 (q, J = 6.5 Hz, 1H), 3.90 (q, J = 6.5 Hz, 1H), carboxamide 3.81 (s, 3H), 1.72 (s, 3H); LCMS (M / Z): 465.25 N-(2-(4-chlorothiazol-2-yl)-2-1H-NMR (400 MHz, DMSO-D6) δ 8.91 (t, J = 6.4 Hz, 1H), (1-methyl-1H-pyrazol-4- 7.81 (s, 1H), 7.74 (s, 2H), 7.61 (s, 1H), 7.51 (d, J = 0.7 Hz, 126 yl)propyl)-2-(3,5- 1H), 7.27 (s, 1H), 4.04 (q, J = 6.6 Hz, 1H), 3.89 (q, J = 6.6 dimethylphenyl)-2H-tetrazole-5- Hz, 1H), 3.81 (s, 3H), 2.38 (d, J = 20.5 Hz, 6H), 1.71 (s, 3H); carboxamide LCMS (M / Z): 455.15 N-(2-(4-chlorothiazol-2-yl)-2-1H-NMR (400 MHz, DMSO-D6) δ 8.98 (t, J = 6.4 Hz, 1H), (1-methyl-1H-pyrazol-4- 8.35 (d, J = 8.6 Hz, 2H), 8.09 (d, J = 8.6 Hz, 2H), 7.81 (s, 127 yl)propyl)-2-(4- 1H), 7.61 (s, 1H), 7.52 (d, J = 0.7 Hz, 1H), 4.05 (q, J = 6.6 (trifluoromethyl)phenyl)-2H- Hz, 1H), 3.90 (q, J = 6.6 Hz, 1H), 3.81 (s, 3H), 1.72 (s, 3H); tetrazole-5-carboxamide LCMS (M / Z): 498.25 N-(2-(5-chloro-1-methyl-1H-1H-NMR (400 MHz, DMSO-D6) δ 9.02 (d, J = 1.5 Hz, 1H), 128 pyrazol-4-yl)-2-(4- 8.48 (t, J = 6.6 Hz, 1H), 7.92 (td, J = 8.8, 5.9 Hz, 1H), 7.76 chlorothiazol-2-yl)propyl)-1- (s, 1H), 7.73-7.67 (m, 2H), 7.39-7.35 (m, 1H), 4.10 (q, J = (2,4-difluorophenyl)-1H-1,2,3- 6.6 Hz, 1H), 3.98 (q, J = 6.6 Hz, 1H), 3.77 (s, 3H), 1.71 (s, triazole-4-carboxamide 3H); LCMS (M / Z): 498.2 1 N-(2-(4-chlorothiazol-2-yl)-2- H-NMR (400 MHz, DMSO-D6) δ 8.87 (t, J = 6.4 Hz, 1H), 7.80 (s, 1H), 7.74 (dd, J = 8.8, 6.1 Hz, 1H), 7.60 (s, 1H), 7.51 129 (1-methyl-1H-pyrazol-4- yl)propyl)-2-(2-ethoxy-4- (s, 1H), 7.33 (dd, J = 10.9, 2.6 Hz, 1H), 7.03 (td, J = 8.4, 2.6 fluorophenyl)-2H-tetrazole-5- Hz, 1H), 4.15 (q, J = 6.9 Hz, 2H), 4.03 (q, J = 6.6 Hz, 1H), carboxamide 3.88 (q, J = 6.6 Hz, 1H), 3.81 (s, 3H), 1.71 (s, 3H), 1.17 (t, J = 7.0 Hz, 3H); LCMS (M / Z): 490.9 N-(2-(5-chloro-1-methyl-1H-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.38 (t, J = 6.2 pyrazol-4-yl)-2-(4- Hz, 1H), 8.24-8.18 (m, 2H), 7.51 (d, J = 4.2 Hz, 1H), 7.30- 130 chlorothiazol-2-yl)propyl)-2-(4- 7.27 (m, 1H), 7.25 (d, J = 3.4 Hz, 1H), 7.09 (s, 1H), 4.29 (dd, fluorophenyl)-2H-tetrazole-5- J = 13.6, 5.5 Hz, 1H), 4.17 (dd, J = 13.7, 7.3 Hz, 1H), 3.83 carboxamide (s, 3H), 1.85 (s, 3H); LCMS (M / Z): 480.75 N-(2-(5-chloro-1-methyl-1H-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.36 (t, J = 6.1 131 pyrazol-4-yl)-2-(4- Hz, 1H), 8.22-8.20 (m, 2H), 7.60-7.53 (m, 3H), 7.51 (s, 1H), chlorothiazol-2-yl)propyl)-2- 7.09 (s, 1H), 4.30 (dd, J = 13.6, 5.5 Hz, 1H), 4.18 (dd, J = phenyl-2H-tetrazole-5- 13.4, 7.3 Hz, 1H), 3.83 (s, 3H), 1.86 (s, 3H); LCMS (M / Z): carboxamide 462.8 N-(2-(5-chloro-1-methyl-1H-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.42 (s, 1H), 132 pyrazol-4-yl)-2-(4- 7.92 (t, J = 6.1 Hz, 1H), 7.73-7.70 (m, 2H), 7.52 (s, 1H), 7.28 chlorothiazol-2-yl)propyl)-1-(4- (d, J = 3.4 Hz, 1H), 7.25-7.23 (m, 1H), 7.07 (s, 1H), 4.28 (dd, fluorophenyl)-1H-1,2,3-triazole- J = 13.6, 6.0 Hz, 1H), 4.17 (dd, J = 13.6, 7.2 Hz, 1H), 3.83 4-carboxamide (s, 3H), 1.85 (s, 3H); LCMS (M / Z): 479.7 PI External N-(2-(5-chloro-1-methyl-1H-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.35 (t, J = 6.1 133 pyrazol-4-yl)-2-(4- Hz, 1H), 7.93-7.87 (m, 1H), 7.51 (s, 1H), 7.17-7.10 (m, 2H), chlorothiazol-2-yl)propyl)-2- 7.09 (d, J = 3.2 Hz, 1H), 4.30 (dd, J = 13.6, 5.5 Hz, 1H), 4.18 (2,4-difluorophenyl)-2H- (dd, J = 13.7, 7.3 Hz, 1H), 3.83 (s, 3H), 1.86 (s, 3H); LCMS tetrazole-5-carboxamide (M / Z): 499.05 N-(2-(5-chloro-1-methyl-1H-1pyrazol-4-yl)-2-(4- H-NMR (500 MHz, CHLOROFORM-D) δ 8.28 (d, J = 5.1 134 chlorothiazol-2-yl)propyl)-2- Hz, 1H), 8.03-8.00 (m, 1H), 7.91-7.86 (m, 1H), 7.51 (s, 1H), (2,4-difluorophenyl)-2H-1,2,3- 7.09-7.02 (m, 3H), 4.22-4.07 (m, 2H), 3.82 (s, 3H), 1.83 (s, triazole-4-carboxamide 3H); LCMS (M / Z): 498 N-(2-(5-chloro-1-methyl-1H-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.56 (d, J = 2.7 135 pyrazol-4-yl)-2-(4- Hz, 1H), 7.96-7.92 (m, 2H), 7.53-7.46 (m, 2H), 7.37-7.30 (m, chlorothiazol-2-yl)propyl)-1-(2- 2H), 7.07 (s, 1H), 4.28 (dd, J = 13.7, 5.9 Hz, 1H), 4.18 (dd, J fluorophenyl)-1H-1,2,3-triazole- = 13.6, 7.2 Hz, 1H), 3.83 (s, 3H), 1.85 (s, 3H); LCMS (M / Z): 4-carboxamide 480.05 1 N-(2-(5-chloro-1-methyl-1H- H-NMR (400 MHz, CHLOROFORM-D) δ 8.43 (t, J = 6.1 pyrazol-4-yl)-2-(4- Hz, 1H), 8.04 (dd, J = 8.2, 1.6 Hz, 1H), 7.97 (dt, J = 9.0, 2.2 136 chlorothiazol-2-yl)propyl)-2-(3- Hz, 1H), 7.57 (td, J = 8.3, 5.6 Hz, 1H), 7.51 (d, J = 3.9 Hz, fluorophenyl)-2H-tetrazole-5- 1H), 7.25-7.23 (m, 1H), 7.10 (s, 1H), 4.29 (dd, J = 13.6, 5.5 carboxamide Hz, 1H), 4.17 (dd, J = 13.4, 7.3 Hz, 1H), 3.83 (s, 3H), 1.85 (s, 3H); LCMS (M / Z): 481 N-(2-(5-chloro-1-methyl-1H-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.48 (d, J = 4.2 pyrazol-4-yl)-2-(4- Hz, 1H), 7.91 (t, J = 6.4 Hz, 1H), 7.75-7.72 (m, 2H), 7.57- 137 chlorothiazol-2-yl)propyl)-1- 7.52 (m, 3H), 7.51-7.47 (m, 1H), 7.07 (s, 1H), 4.28 (dd, J = phenyl-1H-1,2,3-triazole-4- 13.6, 6.0 Hz, 1H), 4.18 (dd, J = 13.6, 7.2 Hz, 1H), 3.83 (s, carboxamide 3H), 1.85 (s, 3H); LCMS (M / Z): 461.9 N-(2-(5-chloro-1-methyl-1H-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.47 (s, 1H), pyrazol-4-yl)-2-(4- 7.98 (t, J = 6.5 Hz, 1H), 7.52 (s, 1H), 7.36 (dd, J = 7.2, 2.3 138 chlorothiazol-2-yl)propyl)-1- Hz, 2H), 7.07 (s, 1H), 6.95 (tt, J = 8.6, 2.2 Hz, 1H), 4.27 (dd, (3,5-difluorophenyl)-1H-1,2,3- J = 13.4, 5.9 Hz, 1H), 4.16 (dd, J = 13.6, 7.2 Hz, 1H), 3.84 triazole-4-carboxamide (s, 3H), 1.84(s, 3H); LCMS (M / Z): 498 N-(2-(5-chloro-1-methyl-1H-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.33 (t, J = 6.2 pyrazol-4-yl)-2-(4- Hz, 1H), 7.92-7.88 (m, 1H), 7.60-7.55 (m, 1H), 7.52 (s, 1H), 139 chlorothiazol-2-yl)propyl)-2-(2- 7.41-7.35 (m, 2H), 7.09 (s, 1H), 4.30 (dd, J = 13.6, 5.5 Hz, fluorophenyl)-2H-tetrazole-5- 1H), 4.19 (dd, J = 13.7, 7.3 Hz, 1H), 3.83 (s, 3H), 1.86 (s, carboxamide 3H); LCMS (M / Z): 480.95 1 N-(2-(1-methyl-1H-pyrazol-4- H-NMR (400 MHz, CHLOROFORM-D) δ 8.72 (d, J = 6.1 140 yl)-2-(4-methylthiazol-2- Hz, 1H), 8.21-8.18 (m, 2H), 7.60-7.52 (m, 3H), 7.44 (d, J = yl)propyl)-2-phenyl-2H- 7.6 Hz, 2H), 6.85 (d, J = 1.0 Hz, 1H), 4.17 (ddd, J = 37.8, tetrazole-5-carboxamide 13.4, 6.2 Hz, 2H), 3.89 (s, 3H), 2.55 (d, J = 1.0 Hz, 3H), 1.87 (s, 3H); LCMS (M / Z): 409.05 1 2-(2-fluorophenyl)-N-(2-(1- H-NMR (400 MHz, CHLOROFORM-D) δ 8.64 (s, 1H), methyl-1H 7.93-7.88 (m, 1H), 7.60-7.54 (m, 2H), 7.49 (s, 1H), 7.41-7.35 141 -pyrazol-4-yl)-2-(4- methylthiazol-2-yl)propyl)-2H- (m, 2H), 6.89 (s, 1H), 4.30 (q, J = 6.6 Hz, 1H), 4.15 (q, J = tetrazole-5-carboxamide 6.8 Hz, 1H), 3.93 (s, 3H), 2.57 (s, 3H), 1.93 (s, 3H); LCMS (M / Z): 427.05 1H-NMR (400 MHz, CHLOROFORM-D) δ 8.73-8.70 (m, 2-(3-fluorophenyl)-N-(2-(1- 1H), 8.03 (dd, J = 8.1, 1.7 Hz, 1H), 7.95 (dt, J = 9.1, 2.3 Hz, 142 methyl-1H-pyrazol-4-yl)-2-(4- 1H), 7.59-7.52 (m, 1H), 7.47 (d, J = 1.7 Hz, 2H), 7.25-7.22 methylthiazol-2-yl)propyl)-2H- (m, 1H), 6.88 (d, J = 1.0 Hz, 1H), 4.25 (dd, J = 13.4, 6.1 Hz, tetrazole-5-carboxamide 1H), 4.15-4.08 (m, 1H), 3.91 (s, 3H), 2.57 (d, J = 1.0 Hz, 3H), 1.89 (s, 3H); LCMS (M / Z): 427.15 143 2-(4-fluorophenyl)-N-(2-(1-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.68 (t, J = 5.7 methyl-1H-pyrazol-4-yl)-2-(4- Hz, 1H), 8.22-8.16 (m, 2H), 7.46 (s, 2H), 7.28 (dd, J = 7.5, PI External methylthiazol-2-yl)propyl)-2H- 1.6 Hz, 2H), 6.87 (d, J = 0.7 Hz, 1H), 4.27-4.10 (m, 2H), 3.90 tetrazole-5-carboxamide (s, 3H), 2.56 (d, J = 0.7 Hz, 3H), 1.89 (s, 3H); LCMS (M / Z): 427.25 1 2-(2,4-difluorophenyl)-N-(2-(1- H-NMR (400 MHz, CHLOROFORM-D) δ 8.47 (s, 1H), 144 methyl-1H-pyrazol-4-yl)-2-(4- 7.93-7.89 (m, 1H), 7.67 (s, 1H), 7.54 (s, 1H), 7.16-7.10 (m, methylthiazol-2-yl)propyl)-2H- 2H), 6.96 (s, 1H), 4.44-4.39 (m, 1H), 4.19 (dd, J = 13.6, 6.2 tetrazole-5-carboxamide Hz, 1H), 3.97 (s, 3H), 2.62 (s, 3H), 2.01 (s, 3H); LCMS (M / Z): 445.10 1 N-(2-(1-methyl-1H-pyrazol-4- H-NMR (400 MHz, CHLOROFORM-D) δ 8.47 (d, J = 2.4 145 yl)-2-(4-methylthiazol-2- Hz, 1H), 8.21 (t, J = 6.5 Hz, 1H), 7.75-7.71 (m, 2H), 7.57- yl)propyl)-1-phenyl-1H-1,2,3- 7.52 (m, 2H), 7.50-7.46 (m, 2H), 7.41 (s, 1H), 6.83 (d, J = triazole-4-carboxamide 1.0 Hz, 1H), 4.19-4.03 (m, 2H), 3.89 (s, 3H), 2.54 (d, J = 0.9 Hz, 3H), 1.85 (s, 3H); LCMS (M / Z): 408.05 1H-NMR (400 MHz, CHLOROFORM-D) δ 8.56 (d, J = 2.8 1-(2-fluorophenyl)-N-(2-(1- Hz, 1H), 8.11 (t, J = 6.0 Hz, 1H), 7.95-7.91 (m, 1H), 7.56 (s, 146 methyl-1H-pyrazol-4-yl)-2-(4- 1H), 7.52-7.51 (m, 1H), 7.50-7.46 (m, 1H), 7.37-7.30 (m, methylthiazol-2-yl)propyl)-1H- 2H), 6.88 (d, J = 1.2 Hz, 1H), 4.22 (ddd, J = 31.4, 13.6, 6.5 1,2,3-triazole-4-carboxamide Hz, 2H), 3.93 (s, 3H), 2.59 (d, J = 1.0 Hz, 3H), 1.92 (s, 3H); LCMS (M / Z): 426.2 1H-NMR (400 MHz, CHLOROFORM-D) δ 8.43 (d, J = 3.4 1-(4-fluorophenyl)-N-(2-(1- Hz, 1H), 8.23 (t, J = 6.0 Hz, 1H), 7.74-7.69 (m, 2H), 7.46 (d, 147 methyl-1H-pyrazol-4-yl)-2-(4- J = 4.4 Hz, 1H), 7.40 (s, 1H), 7.28-7.22 (m, 2H), 6.83 (d, J = methylthiazol-2-yl)propyl)-1H- 1.0 Hz, 1H), 4.13 (ddd, J = 26.1, 13.4, 6.4 Hz, 2H), 3.89 (s, 1,2,3-triazole-4-carboxamide 3H), 2.54 (d, J = 1.0 Hz, 3H), 1.85 (s, 3H); LCMS (M / Z): 426.05 1H-NMR (400 MHz, CHLOROFORM-D) δ 8.50 (d, J = 2.4 1-(2,4-difluorophenyl)-N-(2-(1- Hz, 1H), 8.17 (d, J = 6.1 Hz, 1H), 7.90 (td, J = 8.6, 5.8 Hz, 148 methyl-1H-pyrazol-4-yl)-2-(4- 1H), 7.52-7.48 (m, 2H), 7.12-7.07 (m, 2H), 6.87 (d, J = 1.0 methylthiazol-2-yl)propyl)-1H- Hz, 1H), 4.24 (q, J = 6.6 Hz, 1H), 4.16 (q, J = 6.7 Hz, 1H), 1,2,3-triazole-4-carboxamide 3.92 (s, 3H), 2.58 (d, J = 1.0 Hz, 3H), 1.90 (s, 3H); LCMS (M / Z): 444.05 1H-NMR (400 MHz, CHLOROFORM-D) δ 8.51 (d, J = 8.1 1-(3,5-difluorophenyl)-N-(2-(1- Hz, 1H), 8.27 (t, J = 6.1 Hz, 1H), 7.48 (s, 1H), 7.46 (s, 1H), 149 methyl-1H-pyrazol-4-yl)-2-(4- 7.37 (dq, J = 12.5, 2.5 Hz, 2H), 6.94 (tt, J = 8.6, 2.3 Hz, 1H), methylthiazol-2-yl)propyl)-1H- 6.85 (d, J = 1.0 Hz, 1H), 4.20 (q, J = 6.6 Hz, 1H), 4.11 (q, J 1,2,3-triazole-4-carboxamide = 6.7 Hz, 1H), 3.90 (s, 3H), 2.56 (d, J = 1.0 Hz, 3H), 1.87 (s, 3H); LCMS (M / Z): 444.1 1H-NMR (400 MHz, CHLOROFORM-D) δ 8.27 (t, J = 2.6 2-(2,4-difluorophenyl)-N-(2-(1- Hz, 1H), 8.13 (d, J = 6.6 Hz, 1H), 7.87 (td, J = 8.9, 5.8 Hz, 150 methyl-1H-pyrazol-4-yl)-2-(4- 1H), 7.58 (s, 1H), 7.51 (s, 1H), 7.09-7.02 (m, 2H), 6.90 (d, J methylthiazol-2-yl)propyl)-2H- = 1.0 Hz, 1H), 4.25 (dd, J = 13.7, 6.4 Hz, 1H), 4.11 (q, J = 1,2,3-triazole-4-carboxamide 6.7 Hz, 1H), 3.94 (s, 3H), 2.57 (d, J = 1.0 Hz, 3H), 1.95 (s, 3H); LCMS (M / Z): 444.1 1 1-(2,4-difluorophenyl)-N-(2-(1- H-NMR (400 MHz, CHLOROFORM-D) δ 8.72 (s, 1H), 151 methyl-1H-pyrazol-4-yl)-2-(4- 8.21 (s, 1H), 8.10 (d, J = 7.1 Hz, 1H), 7.73-7.68 (m, 1H), 7.54 methylthiazol-2-yl)propyl)-1H- (s, 1H), 7.50 (s, 1H), 7.23-7.19 (m, 1H), 7.03-6.97 (m, 1H), pyrazole-3-carboxamide 6.95 (s, 1H), 4.29-4.26 (m, 1H), 3.92 (dd, J = 14.4, 4.2 Hz, 4H), 2.59 (s, 3H), 2.01 (s, 3H); LCMS (M / Z): 443.25 N-(2-(5-chloro-1-methyl-1H-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.51 (d, J = 2.4 152 pyrazol-4-yl)-2-(4,5- Hz, 1H), 7.94-7.89 (m, 1H), 7.83 (t, J = 6.6 Hz, 1H), 7.53 (s, dichlorothiazol-2-yl)propyl)-1- 1H), 7.13-7.07 (m, 2H), 4.24 (dd, J = 13.7, 6.1 Hz, 1H), 4.16 (2,4-difluorophenyl)-1H-1,2,3- (dd, J = 13.7, 7.3 Hz, 1H), 3.85 (s, 3H), 1.82 (s, 3H); LCMS triazole-4-carboxamide (M / Z): 533.7 PI External N-(2-(5-chloro-1-methyl-1H-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.43 (s, 1H), 153 pyrazol-4-yl)-2-(4,5- 7.81 (t, J = 6.5 Hz, 1H), 7.73-7.69 (m, 2H), 7.53 (d, J = 5.4 dichlorothiazol-2-yl)propyl)-1- Hz, 1H), 7.28-7.27 (m, 1H), 7.25-7.23 (m, 1H), 4.24 (dd, J = (4-fluorophenyl)-1H-1,2,3- 13.7, 6.1 Hz, 1H), 4.15 (dd, J = 13.7, 7.3 Hz, 1H), 3.85 (s, triazole-4-carboxamide 3H), 1.82 (s, 3H); LCMS (M / Z): 513.65 N-(2-(5-chloro-1-methyl-1H-1pyrazol-4-yl)-2-(4,5- H-NMR (400 MHz, CHLOROFORM-D) δ 8.27 (s, 1H), 154 dichlorothiazol-2-yl)propyl)-2- 7.89-7.81 (m, 2H), 7.52 (d, J = 2.7 Hz, 1H), 7.10-7.02 (m, (2,4-difluorophenyl)-2H-1,2,3- 2H), 4.18-4.07 (m, 2H), 3.84 (s, 3H), 1.81 (s, 3H); LCMS triazole-4-carboxamide (M / Z): 533.7 N-(2-(5-chloro-1-methyl-1H- pyrazol-4-yl)-2-(4,5-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.23-8.17 (m, 155 dichlorothiazol-2-yl)propyl)-2- 3H), 7.52 (d, J = 2.9 Hz, 1H), 7.31-7.25 (m, 2H), 4.28-4.15 (4-fluorophenyl)-2H-tetrazole-5- (m, 2H), 3.84 (s, 3H), 1.83 (s, 3H); LCMS (M / Z): 514.90 carboxamide N-(2-(5-chloro-1-methyl-1H-1pyrazol-4-yl)-2-(4,5- H-NMR (400 MHz, CHLOROFORM-D) δ 8.23 (t, J = 6.4 dichlorothiazol-2-yl)propyl)-2- Hz, 1H), 8.04 (dd, J = 8.1, 1.7 Hz, 1H), 7.97 (dt, J = 9.0, 2.2 156 (3-fluorophenyl)-2H-tetrazole-5- Hz, 1H), 7.60-7.52 (m, 2H), 7.28-7.23 (m, 1H), 4.28-4.15 (m, carboxamide 2H), 3.84 (s, 3H), 1.83 (s, 3H); LCMS (M / Z): 514.65 1 N-(2-(1,5-dimethyl-1H-pyrazol- H-NMR (400 MHz, CHLOROFORM-D) δ 8.87-8.84 (m, 157 4-yl)-2-(4-methylthiazol-2- 1H), 8.21-8.17 (m, 2H), 7.41 (s, 1H), 7.30-7.27 (m, 1H), 7.25 yl)propyl)-2-(4-fluorophenyl)- (s, 1H), 6.83 (d, J = 1.0 Hz, 1H), 4.16-4.05 (m, 2H), 3.75 (s, 2H-tetrazole-5-carboxamide 3H), 2.52 (d, J = 1.0 Hz, 3H), 1.96 (s, 3H), 1.81 (s, 3H); LCMS (M / Z): 441.35 1H-NMR (400 MHz, CHLOROFORM-D) δ 8.92-8.89 (m, N-(2-(1,5-dimethyl-1H-pyrazol- 1H), 8.03 (dd, J = 8.2, 1.6 Hz, 1H), 7.95 (dt, J = 9.1, 2.3 Hz, 158 4-yl)-2-(4-methylthiazol-2- 1H), 7.56 (td, J = 8.3, 5.9 Hz, 1H), 7.41 (s, 1H), 7.24 (ddd, J yl)propyl)-2-(3-fluorophenyl)- = 8.3, 2.5, 0.8 Hz, 1H), 6.83 (d, J = 1.0 Hz, 1H), 4.16-4.05 2H-tetrazole-5-carboxamide (m, 2H), 3.75 (s, 3H), 2.53 (d, J = 1.0 Hz, 3H), 1.96 (s, 3H), 1.81 (s, 3H); LCMS (M / Z): 441.3 N-(2-(1,5-dimethyl-1H-pyrazol-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.85 (s, 1H), 159 4-yl)-2-(4-methylthiazol-2- 8.21-8.18 (m, 2H), 7.60-7.53 (m, 3H), 7.42 (s, 1H), 6.83 (d, yl)propyl)-2-phenyl-2H- J = 1.2 Hz, 1H), 4.17-4.07 (m, 2H), 3.75 (s, 3H), 2.52 (d, J = tetrazole-5-carboxamide 1.0 Hz, 3H), 1.96 (s, 3H), 1.81 (s, 3H); LCMS (M / Z): 423.35 1 2-(3,5-difluorophenyl)-N-(2- H-NMR (400 MHz, CHLOROFORM-D) δ 8.98-8.95 (m, 160 (1,5-dimethyl-1H-pyrazol-4-yl)- 1H), 7.81 (dq, J = 12.5, 2.5 Hz, 2H), 7.40 (s, 1H), 7.00 (tt, J 2-(4-methylthiazol-2-yl)propyl)- = 8.6, 2.3 Hz, 1H), 6.83 (d, J = 1.0 Hz, 1H), 4.15-4.05 (m, 2H-tetrazole-5-carboxamide 2H), 3.75 (s, 3H), 2.52 (d, J = 1.0 Hz, 3H), 1.96 (s, 3H), 1.81 (s, 3H), 1.66 (s, 3H); LCMS (M / Z): 459.40 1-(2,4-difluorophenyl)-N-(2-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.50 (d, J = 2.7 161 (1,5-dimethyl-1H-pyrazol-4-yl)- Hz, 1H), 8.45-8.42 (m, 1H), 7.93-7.87 (m, 1H), 7.44 (s, 1H), 2-(4-methylthiazol-2-yl)propyl)- 7.12-7.06 (m, 2H), 6.81 (d, J = 1.0 Hz, 1H), 4.14-4.04 (m, 1H-1,2,3-triazole-4- 2H), 3.75 (s, 3H), 2.51 (d, J = 1.0 Hz, 3H), 1.94 (s, 3H), 1.80 carboxamide (s, 3H); LCMS (M / Z): 458.15 N-(2-(1,5-dimethyl-1H-pyrazol-14-yl)-2-(4 H-NMR (400 MHz, CHLOROFORM-D) δ 8.43 (s, 2H), 162 -methylthiazol-2- yl)propyl)-1-(4-fluorophenyl)- 7.73-7.70 (m, 2H), 7.44 (s, 1H), 7.25-7.23 (m, 2H), 6.81 (d, 1H-1,2,3-triazole-4- J = 1.0 Hz, 1H), 4.11-4.07 (m, 2H), 3.75 (s, 3H), 2.52 (d, J = carboxamide 1.0 Hz, 3H), 1.94 (s, 3H), 1.80 (s, 3H); LCMS (M / Z): 440.25 N-(2-(1,5-1163 dimethyl-1H-pyrazol- H-NMR (400 MHz, CHLOROFORM-D) δ 8.56 (d, J = 2.7 4-yl)-2-(4-methylthiazol-2- Hz, 1H), 8.42 (t, J = 6.1 Hz, 1H), 7.95-7.91 (m, 1H), 7.52- yl)propyl)-1-(2-fluorophenyl)- 7.46 (m, 1H), 7.45 (d, J = 2.4 Hz, 1H), 7.37-7.34 (m, 1H), PI External 1H-1,2,3-triazole-4- 7.33-7.30 (m, 1H), 6.81 (d, J = 1.2 Hz, 1H), 4.15-4.04 (m, carboxamide 2H), 3.75 (s, 3H), 2.52 (d, J = 1.0 Hz, 3H), 1.94 (s, 3H), 1.81 (s, 3H); LCMS (M / Z): 440.45 1 N-(2-(1,5-dimethyl-1H-pyrazol- H-NMR (400 MHz, CHLOROFORM-D) δ 8.48 (s, 1H), 164 4-yl)-2-(4-methylthiazol-2- 8.42-8.39 (m, 1H), 7.75-7.72 (m, 2H), 7.57-7.53 (m, 2H), yl)propyl)-1-phenyl-1H-1,2,3- 7.50-7.45 (m, 2H), 6.81 (d, J = 1.0 Hz, 1H), 4.15-4.04 (m, triazole-4-carboxamide 2H), 3.75 (s, 3H), 2.52 (d, J = 1.0 Hz, 3H), 1.94 (s, 3H), 1.80 (s, 3H); LCMS (M / Z): 422.3 2-(2,4-difluorophenyl)-N-(2-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.46 (dd, J = (1,5-dimethyl-1H-pyrazol-4-yl)- 6.7, 4.8 Hz, 1H), 8.27 (s, 1H), 7.88-7.82 (m, 1H), 7.43 (s, 165 2-(4-methylthiazol-2-yl)propyl)- 1H), 7.10-7.00 (m, 2H), 6.81 (d, J = 1.0 Hz, 1H), 4.09-3.96 2H-1,2,3-triazole-4- (m, 2H), 3.75 (s, 3H), 2.47 (d, J = 1.0 Hz, 3H), 1.93 (s, 3H), carboxamide 1.78 (s, 3H); LCMS (M / Z): 458.5 N-(2-(1,5-dimethyl-1H-pyrazol-1H-NMR (500 MHz, CHLOROFORM-D) δ 8.47 (s, 1H), 4-yl)-2-(4-methylthiazol-2- 8.45 (dd, J = 6.6, 5.4 Hz, 1H), 7.57-7.50 (m, 3H), 7.45 (s, 166 yl)propyl)-1-(3-fluorophenyl)- 1H), 7.21-7.17 (m, 1H), 6.81 (d, J = 1.1 Hz, 1H), 4.14-4.04 1H-1,2,3-triazole-4- (m, 2H), 3.75 (s, 3H), 2.52 (d, J = 1.0 Hz, 3H), 1.94 (s, 3H), carboxamide 1.80 (s, 3H); LCMS (M / Z): 440.20 1H-NMR (500 MHz, CHLOROFORM-D) δ 8.93 (dd, J = 2-(3-bromophenyl)-N-(2-(1,5- 6.9, 4.7 Hz, 1H), 8.41 (t, J = 2.0 Hz, 1H), 8.17 (ddd, J = 8.2, 167 dimethyl-1H-pyrazol-4-yl)-2-(4- 2.1, 0.5 Hz, 1H), 7.68-7.66 (m, 1H), 7.46 (t, J = 8.1 Hz, 1H), methylthiazol-2-yl)propyl)-2H- 7.41 (s, 1H), 6.83 (d, J = 0.9 Hz, 1H), 4.16-4.06 (m, 2H), 3.75 tetrazole-5-carboxamide (s, 3H), 2.53 (d, J = 0.7 Hz, 3H), 1.96 (s, 3H), 1.81 (s, 3H); LCMS (M / Z): 502.5 1H-NMR (400 MHz, DMSO-D6) δ 8.31 (t, J = 6.2 Hz, 1H), 1-(2,4-difluorophenyl)-N-(2- 7.77 (d, J = 2.0 Hz, 1H), 7.49 (td, J = 8.8, 5.9 Hz, 1H), 7.44- 168 (1,5-dimethyl-1H-pyrazol-4-yl)- 7.38 (m, 1H), 7.33 (s, 1H), 7.20-7.16 (m, 1H), 7.12 (d, J = 2-(4-methylthiazol-2-yl)propyl)- 1.0 Hz, 1H), 6.91 (d, J = 2.0 Hz, 1H), 3.85 (dd, J = 8.4, 6.7 1H-pyrazole-3-carboxamide Hz, 2H), 3.64 (s, 3H), 2.33 (d, J = 1.0 Hz, 3H), 1.87 (s, 3H), 1.58 (s, 3H); LCMS (M / Z): 457.2 1H-NMR (400 MHz, DMSO-D6) δ 8.25-8.20 (m, 2H), 7.84 1-(2,4-difluorophenyl)-N-(2- (td, J = 8.9, 6.0 Hz, 1H), 7.64-7.58 (m, 1H), 7.39 (s, 1H), 169 (1,5-dimethyl-1H-pyrazol-4-yl)- 7.34-7.29 (m, 1H), 7.17 (d, J = 1.2 Hz, 1H), 6.87 (d, J = 2.4 2-(4-methylthiazol-2-yl)propyl)- Hz, 1H), 3.95 (dd, J = 13.4, 5.6 Hz, 1H), 3.83 (q, J = 6.8 Hz, 1H-pyrazole-4-carboxamide 1H), 3.66 (s, 3H), 2.35 (d, J = 0.7 Hz, 3H), 1.87 (s, 3H), 1.64 (s, 3H); LCMS (M / Z): 457.35 1H-NMR (400 MHz, CHLOROFORM-D) δ 8.49 (s, 1H), N-(2-(1-methyl-1H-pyrazol-4- 7.74-7.71 (m, 2H), 7.57-7.52 (m, 2H), 7.50-7.46 (m, 1H), 170 yl)-2-(thiophen-2-yl)propyl)-1- 7.45 (d, J = 1.0 Hz, 1H), 7.30-7.28 (m, 1H), 7.24 (d, J = 6.1 phenyl-1H-1,2,3-triazole-4- Hz, 1H), 7.22 (dd, J = 5.0, 1.3 Hz, 1H), 6.99-6.95 (m, 2H), carboxamide 4.05-3.96 (m, 2H), 3.88 (s, 3H), 1.77 (s, 3H); LCMS (M / Z): 393 1-(3-fluorophenyl)-N-(2-(1-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.50 (s, 1H), 171 methyl-1H-pyrazol-4-yl)-2- 7.56-7.50 (m, 3H), 7.45 (d, J = 0.7 Hz, 1H), 7.29 (d, J = 0.5 (thiophen-2-yl)propyl)-1H- Hz, 1H), 7.24-7.17 (m, 3H), 7.00-6.95 (m, 2H), 4.05-3.96 (m, 1,2,3-triazole-4-carboxamide 2H), 3.88 (s, 3H), 1.77 (s, 3H); LCMS (M / Z): 410.95 1 1-(4-fluorophenyl)-N-(2-(1- H-NMR (400 MHz, CHLOROFORM-D) δ 8.43 (s, 1H), 172 methyl-1H-pyrazol-4-yl)-2- 7.73-7.68 (m, 2H), 7.45 (d, J = 0.7 Hz, 1H), 7.29 (d, J = 6.1 (thiophen-2-yl)propyl)-1H- Hz, 1H), 7.25 (d, J = 1.0 Hz, 2H), 7.23-7.19 (m, 2H), 7.00- 1,2,3-triazole-4-carboxamide 6.95 (m, 2H), 4.05-3.96 (m, 2H), 3.88 (d, J = 3.7 Hz, 3H), 1.77 (s, 3H); 410.95 173 1-(2,4-difluorophenyl)-N-(2-(1-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.27 (s, 1H), methyl-1H-pyrazol-4-yl)-2- 7.80-7.74 (m, 1H), 7.44 (d, J = 1.0 Hz, 1H), 7.29 (s, 1H), 7.22 PI External (thiophen-2-yl)propyl)-1H- (dd, J = 5.1, 1.2 Hz, 1H), 7.08-7.00 (m, 2H), 7.00-6.97 (m, 1,2,3-triazole-4-carboxamide 1H), 6.95 (dd, J = 3.4, 1.2 Hz, 1H), 6.83 (t, J = 6.2 Hz, 1H), 4.02-3.92 (m, 2H), 3.88 (s, 3H), 1.76 (s, 3H); LCMS (M / Z): 429.15 1 2-(3,5-difluorophenyl)-N-(2-(1- H-NMR (400 MHz, CHLOROFORM-D) δ 7.79 (dq, J = 174 methyl-1H-pyrazol-4-yl)-2- 12.5, 2.6 Hz, 2H), 7.45 (d, J = 1.0 Hz, 1H), 7.31 (d, J = 0.7 (thiophen-2-yl)propyl)-2H- Hz, 1H), 7.24 (dd, J = 5.1, 1.2 Hz, 1H), 7.19 (t, J = 6.1 Hz, tetrazole-5-carboxamide 1H), 7.03-6.96 (m, 3H), 4.11-4.01 (m, 2H), 3.89 (s, 3H), 1.78 (s, 3H); LCMS (M / Z): 430.1 1H-NMR (400 MHz, CHLOROFORM-D) δ 8.00 (dd, J = 2-(3-fluorophenyl)-N-(2-(1- 8.1, 1.7 Hz, 1H), 7.93 (dt, J = 9.0, 2.2 Hz, 1H), 7.56 (td, J = 175 methyl-1H-pyrazol-4-yl)-2- 8.3, 5.9 Hz, 1H), 7.45 (d, J = 0.7 Hz, 1H), 7.32 (d, J = 0.7 Hz, (thiophen-2-yl)propyl)-2H- 1H), 7.26-7.23 (m, 2H), 7.20 (t, J = 5.7 Hz, 1H), 7.00 (dd, J tetrazole-5-carboxamide = 5.1, 3.7 Hz, 1H), 6.97 (dd, J = 3.5, 1.3 Hz, 1H), 4.06 (dq, J = 20.8, 6.6 Hz, 2H), 3.89 (s, 3H), 1.79 (s, 3H); LCMS (M / Z): 412.05 1H-NMR (500 MHz, CHLOROFORM-D) δ 8.05 (dd, J = 2-(4-isopropoxyphenyl)-N-(2- 7.0, 2.2 Hz, 2H), 7.45 (d, J = 0.8 Hz, 1H), 7.32 (d, J = 0.6 Hz, 176 (1-methyl-1H-pyrazol-4-yl)-2- 1H), 7.23 (dd, J = 5.1, 1.2 Hz, 1H), 7.19 (s, 1H), 7.02-6.98 (thiophen-2-yl)propyl)-2H- (m, 3H), 6.96 (dd, J = 3.6, 1.2 Hz, 1H), 4.63 (t, J = 6.1 Hz, tetrazole-5-carboxamide 1H), 4.05 (ddd, J = 25.0, 13.5, 6.3 Hz, 2H), 3.89 (s, 3H), 1.78 (s, 3H), 1.39-1.37 (m, 6H); LCMS (M / Z): 451.9 1 N-(2-(1-methyl-1H-pyrazol-4- H-NMR (400 MHz, CHLOROFORM-D) δ 8.17 (dt, J = 6.5, 177 yl)-2-(thiophen-2-yl)propyl)-2- 1.7 Hz, 2H), 7.60-7.52 (m, 3H), 7.45 (d, J = 1.0 Hz, 1H), 7.32 phenyl-2H-tetrazole-5- (s, 1H), 7.24 (dd, J = 5.0, 1.3 Hz, 1H), 7.20 (d, J = 8.3 Hz, carboxamide 1H), 7.01-6.96 (m, 2H), 4.06 (dq, J = 21.5, 6.6 Hz, 2H), 3.89 (s, 3H), 1.79 (s, 3H); LCMS (M / Z): 393.95 1-(3,5-difluorophenyl)-N-(2-(1-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.53 (s, 1H), 178 methyl-1H-pyrazol-4-yl)-2- 7.45 (d, J = 0.7 Hz, 1H), 7.39-7.34 (m, 2H), 7.29 (d, J = 0.7 (thiophen-2-yl)propyl)-1H- Hz, 1H), 7.23-7.20 (m, 2H), 6.99-6.92 (m, 3H), 4.05-3.96 (m, 1,2,3-triazole-4-carboxamide 2H), 3.88 (s, 3H), 1.77 (s, 3H); LCMS (M / Z): 428.85 1 1-(2-fluorophenyl)-N-(2-(1- H-NMR (400 MHz, CHLOROFORM-D) δ 8.56 (d, J = 2.7 179 methyl-1H-pyrazol-4-yl)-2- Hz, 1H), 7.94-7.90 (m, 1H), 7.51-7.45 (m, 2H), 7.37-7.30 (m, (thiophen-2-yl)propyl)-1H- 3H), 7.22 (dd, J = 5.0, 1.3 Hz, 2H), 6.99-6.96 (m, 2H), 4.06- 1,2,3-triazole-4-carboxamide 3.97 (m, 2H), 3.89 (s, 3H), 1.78 (s, 3H); LCMS (M / Z): 410.85 1 2-(4-fluorophenyl)-N-(2-(1- H-NMR (400 MHz, CHLOROFORM-D) δ 8.19-8.16 (m, 180 methyl-1H-pyrazol-4-yl)-2- 2H), 7.45 (d, J = 0.7 Hz, 1H), 7.32 (s, 1H), 7.29-7.27 (m, 1H), (thiophen-2-yl)propyl)-2H- 7.25-7.23 (m, 2H), 7.20 (d, J = 5.4 Hz, 1H), 6.99 (dd, J = 5.0, tetrazole-5-carboxamide 3.5 Hz, 1H), 6.97 (dd, J = 3.5, 1.3 Hz, 1H), 4.06 (dq, J = 20.8, 6.6 Hz, 2H), 3.89 (s, 3H), 1.78 (s, 3H); LCMS (M / Z): 411.9 1H-NMR (400 MHz, CHLOROFORM-D) δ 7.64 (ddd, J = 2-(2-chlorophenyl)-N-(2-(1- 7.9, 4.8, 1.5 Hz, 2H), 7.57 (td, J = 7.8, 1.7 Hz, 1H), 7.49 (td, 181 methyl-1H-pyrazol-4-yl)-2- J = 7.6, 1.4 Hz, 1H), 7.45 (d, J = 0.7 Hz, 1H), 7.33 (s, 1H), (thiophen-2-yl)propyl)-2H- 7.24 (dd, J = 4.9, 1.5 Hz, 1H), 7.20 (d, J = 6.8 Hz, 1H), 6.99 tetrazole-5-carboxamide (dd, J = 4.9, 3.4 Hz, 1H), 6.97 (dd, J = 3.5, 1.3 Hz, 1H), 4.07 (ddd, J = 21.0, 13.6, 6.4 Hz, 2H), 3.89 (s, 3H), 1.80 (s, 3H); LCMS (M / Z): 427.9 1 2-(3,5-dimethylphenyl)-N-(2-(1- H-NMR (400 MHz, CHLOROFORM-D) δ 7.79 (s, 2H), 182 methyl-1H-pyrazol-4-yl)-2- 7.45 (d, J = 1.0 Hz, 1H), 7.32 (s, 1H), 7.24 (dd, J = 5.1, 1.2 (thiophen-2-yl)propyl)-2H- Hz, 1H), 7.21-7.18 (m, 1H), 7.15 (s, 1H), 7.00-6.96 (m, 2H), tetrazole-5-carboxamide 4.06 (dq, J = 22.3, 6.6 Hz, 2H), 3.90-3.88 (m, 3H), 2.42 (d, J = 0.5 Hz, 6H), 1.79 (s, 3H); LCMS (M / Z): 421.9 PI External 1H-NMR (400 MHz, CHLOROFORM-D) δ 8.41 (t, J = 2.0 2-(3-bromophenyl)-N-(2-(1- Hz, 1H), 8.16 (dq, J = 8.2, 1.0 Hz, 1H), 7.70 (dq, J = 8.1, 0.9 183 methyl-1H-pyrazol-4-yl)-2- Hz, 1H), 7.50-7.46 (m, 2H), 7.34 (s, 1H), 7.27 (dd, J = 5.1, (thiophen-2-yl)propyl)-2H- 1.2 Hz, 1H), 7.23 (d, J = 5.9 Hz, 1H), 7.02 (dd, J = 5.0, 3.5 tetrazole-5-carboxamide Hz, 1H), 6.99 (dd, J = 3.7, 1.2 Hz, 1H), 4.09 (dq, J = 21.3, 6.6 Hz, 2H), 3.92 (s, 3H), 1.81 (s, 3H); LCMS (M / Z): 473.9 1H-NMR (400 MHz, CHLOROFORM-D) δ 8.05 (d, J = 2.0 N-(2-(1-methyl-1H-pyrazol-4- Hz, 1H), 8.03 (d, J = 1.7 Hz, 1H), 7.45 (d, J = 0.7 Hz, 1H), 184 yl)-2-(thiophen-2-yl)propyl)-2- 7.37 (s, 1H), 7.35 (d, J = 0.7 Hz, 1H), 7.32 (d, J = 0.5 Hz, (p-tolyl)-2H-tetrazole-5- 1H), 7.24 (dd, J = 5.0, 1.3 Hz, 1H), 7.20 (d, J = 5.9 Hz, 1H), carboxamide 7.00-6.96 (m, 2H), 4.06 (ddd, J = 21.9, 13.6, 6.4 Hz, 2H), 3.89 (s, 3H), 2.45 (s, 3H), 1.78 (s, 3H); LCMS (M / Z): 408.15 1 N-(2-(4-chlorothiazol-2-yl)-2- H-NMR (400 MHz, CHLOROFORM-D) δ 8.31-8.28 (m, 185 (1,5-dimethyl-1H-pyrazol-4- 1H), 8.22-8.19 (m, 2H), 7.60-7.53 (m, 3H), 7.45 (s, 1H), 7.07 yl)propyl)-2-phenyl-2H- (s, 1H), 4.22 (dd, J = 13.7, 7.8 Hz, 1H), 4.11 (dd, J = 13.7, tetrazole-5-carboxamide 4.9 Hz, 1H), 3.77 (s, 3H), 2.01 (s, 3H), 1.83 (s, 3H); LCMS (M / Z): 442.85 1H-NMR (400 MHz, CHLOROFORM-D) δ 8.35 (dd, J = N-(2-(4-chlorothiazol-2-yl)-2- 7.3, 4.9 Hz, 1H), 8.04 (dd, J = 8.1, 1.7 Hz, 1H), 7.97 (dt, J = 186 (1,5-dimethyl-1H-pyrazol-4- 9.1, 2.1 Hz, 1H), 7.57 (td, J = 8.3, 5.9 Hz, 1H), 7.44 (s, 1H), yl)propyl)-2-(3-fluorophenyl)- 7.25-7.23 (m, 1H), 7.07 (s, 1H), 4.21 (dd, J = 13.6, 7.9 Hz, 2H-tetrazole-5-carboxamide 1H), 4.10 (dd, J = 13.7, 4.9 Hz, 1H), 3.77 (s, 3H), 2.02 (s, 3H), 1.83 (s, 3H); LCMS (M / Z): 461.05 N-(2-(4-chlorothiazol-2-yl)-2-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.55 (d, J = 2.7 187 (1,5-dimethyl-1H-pyrazol-4- Hz, 1H), 7.96-7.94 (m, 1H), 7.92-7.90 (m, 1H), 7.51-7.45 (m, yl)propyl)-1-(2-fluorophenyl)- 2H), 7.36 (d, J = 7.6 Hz, 1H), 7.33-7.30 (m, 1H), 7.05 (s, 1H), 1H-1,2,3-triazole-4- 4.19-4.12 (m, 2H), 3.77 (s, 3H), 2.01 (s, 3H), 1.82 (s, 3H); carboxamide LCMS (M / Z): 459.8 1 N-(2-(4-chlorothiazol-2-yl)-2- H-NMR (400 MHz, CHLOROFORM-D) δ 8.49 (d, J = 2.0 (1,5-dimethyl- Hz, 1H), 8.02 (s, 1H), 7.74-7.69 (m, 1H), 7.51 (dd, J = 8.2, 188 1H-pyrazol-4- yl)propyl)-1-(2,4- 3.3 Hz, 1H), 7.44 (s, 1H), 7.24-7.20 (m, 1H), 7.05 (d, J = 7.6 difluorophenyl)-1H-pyrazole-3- Hz, 1H), 7.03-6.99 (m, 1H), 4.08 (dd, J = 13.7, 8.1 Hz, 1H), carboxamide 3.91 (dd, J = 13.4, 3.9 Hz, 1H), 3.78 (s, 3H), 2.01 (s, 3H), 1.79 (s, 3H); LCMS (M / Z): 476.8 1 1-(3-fluorophenyl)-N-(2-(1- H-NMR (400 MHz, CHLOROFORM-D) δ 8.47 (s, 1H), 189 methyl-1H-pyrazol-4-yl)-2-(4- 8.33 (s, 1H), 7.57-7.50 (m, 3H), 7.44 (d, J = 1.0 Hz, 1H), 7.32 methylthiazol-2-yl)propyl)-1H- (s, 1H), 7.22-7.17 (m, 1H), 6.80 (d, J = 1.0 Hz, 1H), 4.07 (td, 1,2,3-triazole-4-carboxamide J = 13.5, 6.9 Hz, 2H), 3.86 (s, 3H), 2.52 (d, J = 1.0 Hz, 3H), 1.81 (s, 3H); LCMS (M / Z): 426.35 1 2-(3,5-difluorophenyl)-N-(2-(1- H-NMR (400 MHz, CHLOROFORM-D) δ 8.96 (t, J = 5.6 190 methyl-1H-pyrazol-4-yl)-2-(4- Hz, 1H), 7.85-7.78 (m, 2H), 7.41 (d, J = 0.7 Hz, 1H), 7.33 (d, methylthiazol-2-yl)propyl)-2H- J = 0.5 Hz, 1H), 7.00 (tt, J = 8.5, 2.3 Hz, 1H), 6.82 (d, J = 1.0 tetrazole-5-carboxamide Hz, 1H), 4.16-4.03 (m, 2H), 3.87 (s, 3H), 2.53 (d, J = 1.0 Hz, 3H), 1.81 (s, 3H); LCMS (M / Z): 445.05 N-(2-(4-chlorothiazol-2-yl)-2-1(1,5-dimethyl H-NMR (400 MHz, CHLOROFORM-D) δ 8.52 (s, 1H), 191 -1H-pyrazol-4- yl)propyl)-1-(2,4- 7.96 (t, J = 6.4 Hz, 1H), 7.46 (s, 1H), 7.40-7.36 (m, 2H), 7.05 difluorophenyl)-1H-1,2,3- (s, 1H), 6.94 (tt, J = 8.6, 2.3 Hz, 1H), 4.18-4.09 (m, 2H), 3.77 triazole-4-carboxamide (s, 3H), 2.00 (s, 3H), 1.81 (s, 3H); LCMS (M / Z): 477.75 N-(2-(4-chlorothiazol-2-yl)-2-1(1,5-dimethyl-1H-pyrazo H-NMR (400 MHz, CHLOROFORM-D) δ 8.50 (d, J = 2.7 192 l-4- yl)propyl)-1-(3,5- Hz, 1H), 7.94-7.90 (m, 2H), 7.46 (s, 1H), 7.11 (d, J = 8.1 Hz, difluorophenyl)-1H-1,2,3- 1H), 7.09-7.07 (m, 1H), 7.05 (s, 1H), 4.16-4.13 (m, 2H), 3.77 triazole-4-carboxamide (s, 3H), 2.01 (s, 3H), 1.81 (s, 3H); LCMS (M / Z): 478 PI External 2-(4-chlorophenyl)-N-(2-(4-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.47 (s, 1H), chlorothiazol-2-yl)-2-(1,5- 8.33 (s, 1H), 7.57-7.50 (m, 1H), 7.44 (d, J = 1.0 Hz, 1H), 7.32 193 dimethyl-1H-pyrazol-4- (s, 1H), 7.22-7.17 (m, 1H), 6.80 (d, J = 1.0 Hz, 1H), 4.07 (td, yl)propyl)-2H-tetrazole-5- J = 13.5, 6.9 Hz, 2H), 3.86 (s, 3H), 2.52 (d, J = 1.0 Hz, 3H), carboxamide 1.81 (s, 3H); LCMS (M / Z): 476.7 N-(2-(4-chlorothiazol-2-yl)-2-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.48 (s, 1H), 194 (1,5-dimethyl-1H-pyrazol-4- 7.93 (t, J = 6.5 Hz, 1H), 7.57-7.54 (m, 1H), 7.54-7.50 (m, yl)propyl)-1-(3-fluorophenyl)- 2H), 7.46 (s, 1H), 7.22-7.17 (m, 1H), 7.05 (s, 1H), 4.15-4.13 1H-1,2,3-triazole-4- (m, 2H), 3.77 (s, 3H), 2.01 (s, 3H), 1.81 (s, 3H); LCMS carboxamide (M / Z): 459.75 1 N-(2-(4-chlorothiazol-2-yl)-2- H-NMR (400 MHz, CHLOROFORM-D) δ 8.47 (s, 1H), (1,5-dimethyl-1 7.90 (t, J = 6.4 Hz, 1H), 7.75-7.74 (m, 1H), 7.73-7.72 (m, 195 H-pyrazol-4- yl)propyl)-1-phenyl-1H-1,2,3- 1H), 7.57-7.53 (m, 2H), 7.50-7.48 (m, 1H), 7.46 (s, 1H), 7.04 triazole-4-carboxamide (s, 1H), 4.16-4.14 (m, 2H), 3.77 (s, 3H), 2.01 (s, 3H), 1.82 (s, 3H); LCMS (M / Z): 442.05 1 N-(2-(4-chlorothiazol-2-yl)-2- H-NMR (400 MHz, CHLOROFORM-D) δ 8.30 (dd, J = 196 (1,5-dimethyl-1H-pyrazol-4- 6.6, 4.9 Hz, 1H), 8.23-8.18 (m, 2H), 7.44 (s, 1H), 7.29-7.27 yl)propyl)-2-(4-fluorophenyl)- (m, 1H), 7.25 (s, 1H), 7.07 (s, 1H), 4.21 (dd, J = 13.7, 7.8 Hz, 2H-tetrazole-5-carboxamide 1H), 4.10 (dd, J = 13.7, 4.9 Hz, 1H), 3.77 (s, 3H), 2.02 (s, 3H), 1.83 (s, 3H) : LCMS (M / Z): 461.1 N-(2-(4-chlorothiazol-2-yl)-2-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.40 (dd, J = (1,5-dimethyl-1H-pyrazol-4- 7.2, 4.8 Hz, 1H), 7.86-7.80 (m, 2H), 7.43 (s, 1H), 7.07 (s, 197 yl)propyl)-2-(3,5- 1H), 7.00 (tt, J = 8.5, 2.3 Hz, 1H), 4.19 (dd, J = 13.6, 7.9 Hz, difluorophenyl)-2H-tetrazole-5- 1H), 4.08 (dd, J = 13.6, 4.8 Hz, 1H), 3.77 (s, 3H), 2.02 (s, carboxamide 3H), 1.82 (s, 3H) : LCMS (M / Z): 478.75 N-(2-(4-chlorothiazol-2-yl)-2-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.43 (s, 1H), 198 (1,5-dimethyl-1H-pyrazol-4- 7.90 (t, J = 6.4 Hz, 1H), 7.73-7.69 (m, 2H), 7.46 (s, 1H), 7.30- yl)propyl)-1-(4-fluorophenyl)- 7.27 (m, 1H), 7.25-7.23 (m, 1H), 7.05 (s, 1H), 4.18-4.10 (m, 1H-1,2,3-triazole-4- 2H), 3.77 (s, 3H), 2.01 (s, 3H), 1.81 (s, 3H) : LCMS (M / Z): carboxamide 459.75 N-(2-(4-chlorothiazol-2-yl)-2-1H-NMR (500 MHz, CHLOROFORM-D) δ 8.27 (s, 1H), 199 (1,5-dimethyl-1H-pyrazol-4- 7.96 (dd, J = 7.4, 5.0 Hz, 1H), 7.90-7.86 (m, 1H), 7.45 (s, yl)propyl)-2-(2,4- 1H), 7.09-7.02 (m, 3H), 4.12 (dd, J = 13.6, 7.9 Hz, 1H), 4.01 difluorophenyl)-2H-1,2,3- (dd, J = 13.6, 4.8 Hz, 1H), 3.77 (s, 3H), 1.99 (s, 3H), 1.80 (s, triazole-4-carboxamide 3H) : LCMS (M / Z): 478 N-(2-(5-chloro-4-methylthiazol-12-yl)-2-(1-methyl-1H-pyrazol-4- H-NMR (400 MHz, CHLOROFORM-D) δ 7.93-7.87 (m, 200 yl)propyl)-1-(2,4- 1H), 7.34 (d, J = 20.8 Hz, 1H), 7.18-7.10 (m, 2H), 6.60 (dd, difluorophenyl)-1H-1,2,3- J = 11.5, 5.1 Hz, 1H), 5.78 (dd, J = 179.4, 6.7 Hz, 1H), 4.96- triazole-4-carboxamide 3.21 (m, 7H), 1.85-1.68 (m, 3H) : LCMS (M / Z): 476.1 1 N-(2-(5-chloro-4-methylthiazol- H-NMR (400 MHz, CHLOROFORM-D) δ 8.52 (dd, J = 2-yl)-2-(1-methyl-1H-pyrazol-4- 38.8, 2.6 Hz, 1H), 7.95-7.88 (m, 1H), 7.25-7.06 (m, 4H), 6.71 201 yl)propyl)-2-(2,4- (dd, J = 28.9, 5.1 Hz, 1H), 5.74 (dd, J = 240.6, 16.6 Hz, 1H), difluorophenyl)-2H-tetrazole-5- 5.26-4.97 (m, 1H), 4.78-4.56 (m, 3H), 4.51-4.22 (m, 1H), carboxamide 3.92 (d, J = 16.1 Hz, 3H), 3.78-3.38 (m, 1H) : LCMS (M / Z): 474.80 1H-NMR (400 MHz, CHLOROFORM-D) δ 8.44 (d, J = 41.1 N-(2-(5-chloro-4-methylthiazol- Hz, 1H), 7.75-7.71 (m, 2H), 7.28 (d, J = 2.2 Hz, 1H), 7.24- 202 2-yl)-2-(1-methyl-1H-pyrazol-4- 7.13 (m, 3H), 6.71 (dd, J = 30.3, 5.1 Hz, 1H), 6.07-5.38 (m, yl)propyl)-2-(4-fluorophenyl)- 1H), 5.27-4.97 (m, 1H), 4.78-4.56 (m, 3H), 4.52-4.21 (m, 2H-tetrazole-5-carboxamide 1H), 3.94-3.88 (m, 3H), 3.84-3.40 (m, 1H) : LCMS (M / Z): 456.75 203 N-(2-(5-chloro-4-methylthiazol-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.22-8.13 (m, 2-yl)-2-(1-methyl-1H-pyrazol-4- 2H), 7.31-7.28 (m, 2H), 7.21 (d, J = 5.1 Hz, 1H), 7.15 (d, J = PI External yl)propyl)-2-(3-fluorophenyl)- 6.4 Hz, 1H), 6.70 (dd, J = 12.7, 5.1 Hz, 1H), 5.44 (dd, J = 2H-tetrazole-5-carboxamide 35.7, 16.4 Hz, 1H), 5.08-4.80 (m, 1H), 4.78-4.27 (m, 4H), 3.95-3.81 (m, 3H), 3.67-3.45 (m, 1H) : LCMS (M / Z): 457.8 N-(2-(5-chloro-4-methylthiazol-1H-NMR (400 MHz, CHLOROFORM-D) δ 7.92-7.85 (m, 204 2-yl)-2-(1-methyl-1H-pyrazol-4- 1H), 7.20 (d, J = 5.1 Hz, 1H), 7.18-7.10 (m, 3H), 6.70 (dd, J yl)propyl)-2-(3,5- = 12.7, 5.1 Hz, 1H), 5.44 (dd, J = 47.8, 16.8 Hz, 1H), 5.08- difluorophenyl)-2H-tetrazole-5- 4.78 (m, 1H), 4.77-4.27 (m, 4H), 3.95-3.83 (m, 3H), 3.67- carboxamide 3.46 (m, 1H) : LCMS (M / Z): 475.7 N-(2-(5-chloro-4-methylthiazol-12-yl)-2-(1-methyl-1H-pyrazol-4- H-NMR (400 MHz, CHLOROFORM-D) δ 8.53-8.38 (m, 205 yl)propyl)-1-(4-fluorophenyl)- 1H), 7.57-7.52 (m, 3H), 7.21-7.09 (m, 3H), 6.69 (q, J = 4.9 1H-1,2,3-triazole-4- Hz, 1H), 5.91-5.02 (m, 2H), 4.80-3.65 (m, 6H) : LCMS carboxamide (M / Z): 442.8 N-(2-(5-chloro-4-methylthiazol-1H-NMR (400 MHz, CHLOROFORM-D) δ 7.70-7.61 (m, 206 2-yl)-2-(1-methyl-1H-pyrazol-4- 1H), 7.43 (t, J = 6.7 Hz, 1H), 7.25-7.12 (m, 3H), 6.69 (dd, J yl)propyl)-2-(2,4- = 7.6, 5.1 Hz, 1H), 5.33-5.24 (m, 1H), 5.07 (dd, J = 27.9, 16.6 difluorophenyl)-2H-1,2,3- Hz, 1H), 4.31-3.66 (m, 6H), 2.43 (d, J = 2.0 Hz, 3H) : LCMS triazole-4-carboxamide (M / Z): 458 N-(2-(5-chloro-1-methyl-1H-1H-NMR (500 MHz, CHLOROFORM-D) δ 7.76-7.69 (m, 207 pyrazol-4-yl)-2-(5-chloro-4- 1H), 7.60-7.57 (m, 1H), 7.21-7.15 (m, 2H), 7.05-6.92 (m, methylthiazol-2-yl)propyl)-2- 2H), 6.69 (d, J = 2.5 Hz, 1H), 6.59-6.23 (m, 1H), 5.06-4.92 phenyl-2H-tetrazole-5- (m, 1H), 4.84-4.73 (m, 1H), 4.14-4.07 (m, 2H), 3.86-3.80 (m, carboxamide 3H), 3.63 (d, J = 8.4 Hz, 1H) : LCMS (M / Z): 459.85 1 N-(2-(5-chloro-1-methyl-1H- H-NMR (400 MHz, CHLOROFORM-D) δ 8.57 (dd, J = pyrazol-4-yl) 41.0, 2.6 Hz, 1H), 7.98-7.91 (m, 1H), 7.52-7.46 (m, 1H), 208 -2-(5-chloro-4- methylthiazol-2-yl)propyl)-1-(4- 7.38-7.31 (m, 2H), 7.25-7.13 (m, 2H), 6.71 (dd, J = 29.7, 5.0 fluorophenyl)-1H-1,2,3-triazole- Hz, 1H), 5.74 (dd, J = 250.0, 16.8 Hz, 1H), 5.25-4.98 (m, 4-carboxamide 1H), 4.79-4.56 (m, 3H), 4.53-4.22 (m, 1H), 3.94-3.85 (m, 3H), 3.79-3.40 (m, 1H) : LCMS (M / Z): 457 N-(2-(5-chloro-1-methyl-1H-1H-NMR (400 MHz, CHLOROFORM-D) δ 8.20-8.13 (m, pyrazol-4-yl)-2-(5-chloro-4- 2H), 7.61-7.53 (m, 3H), 7.24 (d, J = 5.1 Hz, 1H), 7.20-7.16 209 methylthiazol-2-yl)propyl)-2- (m, 1H), 6.72 (dd, J = 18.8, 5.1 Hz, 1H), 5.44-5.36 (m, 1H), (2,4-difluorophenyl)-2H-1,2,3- 5.13-4.84 (m, 1H), 4.65-4.25 (m, 2H), 3.95-3.88 (m, 3H), triazole-4-carboxamide 3.78-3.52 (m, 3H) : LCMS (M / Z): 431.1 * Compound names generated using Chemdraw Professional 19.1 BIOLOGY EXAMPLES: As described herein the compounds of the general formula (I) show fungicidal activity which is exerted 5 with respect to numerous phytopathogenic fungi which attack on important agricultural crops. The compounds of the present invention were assessed for their activity as described in the following tests: Example 1: Pyricularia oryzae (Rice blast): The compounds were dissolved in 0.3% dimethyl sulfoxide and then added to potato dextrose agar 10 medium just prior to dispensing it into petri dishes. 5 mL medium, with the compound in the desired test concentration, was dispensed into a 60 mm sterile petri-plate. After solidification, each plate was seeded with a 5 mm size mycelial disc taken from the periphery of an actively growing virulent culture plate of Pyricularia oryzae. The plates were incubated in growth chambers at 25oC temperature and PI External 60% relative humidity for seven days and the radial growth was measured and compared to the one of the untreated control. Compounds 1, 2, 3, 5, 6, 7, 8, 11, 13, 14, 15, 16, 21, 23, 26, 28, 29, 30, 31, 32, 33, 35, 36, 37, 39, 40, 41, 42, 43, 45, 46, 47, 50, 53, 55, 56, 57, 58, 59, 60, 61, 62, 64, 68, 71, 72, 73, 74, 76, 77, 82, 85, 86, 5 89, 90, 92, 94, 95, 96, 97, 98, 99, 100, 103, 104, 105, 107, 109, 110, 119, 123, 124, 125, 127, 128, 129, 130, 131, 132, 133, 135, 136, 139, 140, 141, 142, 143, 144, 146, 148, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 162, 163, 167, 169, 172, 174, 175, 177, 180, 183, 184, 185, 186, 187, 190, 191, 196, 197, 198, 200, 201, 202, 203 at 300 ppm gave more than or equal to 70 % control in these tests when compared to the untreated check which showed extensive pathogen growth. 10 Example 2: Alternaria solani (early blight of tomato / potato): The compounds were dissolved in 0.3% dimethyl sulfoxide and then added to potato dextrose agar medium just prior to dispensing it into petri dishes. 5 mL medium, with the compound in the desired concentration, was dispensed into a 60 mm sterile petri-plate. After solidification, each plate was seeded with a 5 mm size mycelial disc taken from the periphery of an actively growing virulent culture plate 15 of Alternaria solani. The plates were incubated in growth chambers at 25oC temperature and 60% relative humidity for seven days and the radial growth was measured and compared to the one of the untreated control. Compounds 1, 2, 5, 6, 7, 8, 21, 23, 32, 33, 35, 36, 37, 50, 57, 58, 64, 76, 89, 90, 94, 95, 96, 97, 103, 104, 109, 119, 124, 125, 128, 129, 130, 131, 132, 133, 136, 139, 140, 141, 142, 143, 144, 146, 148, 20 155, 157, 158, 159, 160, 161, 163, 165, 167, 174, 175, 177, 180, 184, 185, 186, 187, 190, 191, 195, 196, 197, 199, 201, 202 at 300 ppm gave more than or equal to 70 % control in these tests when compared to the untreated check which showed extensive pathogen growth. Example 3: Colletotrichum capsici (anthracnose): The compounds were dissolved in 0.3% dimethyl sulfoxide and then added to potato dextrose agar 25 medium just prior to dispensing it into petri dishes. 5 mL medium, with the compound in the desired concentration, was dispensed into a 60 mm sterile petri-plate. After solidification, each plate was seeded with a 5 mm size mycelial disc taken from the periphery of an actively growing virulent culture plate of Colletotrichum capsici. The plates were incubated in growth chambers at 25oC temperature and 60% relative humidity for seven days and the radial growth was measured and compared to the one of the 30 untreated control. Compounds 1, 2, 3, 4, 5, 6, 7, 8, 16, 21, 22, 23, 28, 29, 30, 31, 32, 33, 35, 36, 37, 38, 40, 55, 57, 58, 59, 74, 77, 89, 90, 94, 95, 96, 97, 98, 103, 104, 105, 106, 107, 108, 109, 117, 118, 119, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 150, 151, 152, 153, 155, 156, 157, 158, 159, 160, 161, 162, 163, 164, 166, 167, 175, 177, 35 180, 182, 183, 184, 185, 186, 187, 188, 189, 190, 191, 194, 195, 196, 197, 198, 200, 201, 202, 203, PI External 204, 205, 207 at 300 ppm gave more than or equal to 70 % control in these tests when compared to the untreated check which showed extensive pathogen growth. Example 4: Corynespora cassiicola (Leaf spot of tomato): The compounds were dissolved in 0.3% dimethyl sulfoxide and then added to potato dextrose agar 5 medium just prior to dispensing it into petri dishes. 5 mL medium, with the compound in the desired concentration, was dispensed into a 60 mm sterile petri-plate. After solidification, each plate was seeded with a 5 mm size mycelial disc taken from the periphery of an actively growing virulent culture plate of Corynespora cassiicola. The plates were incubated in growth chambers at 25oC temperature and 70% relative humidity for seven days and the radial growth was measured and compared to the one of 10 the untreated control. Compounds 1, 8, 21, 23, 32, 35, 36, 37, 38, 57, 58, 89, 94, 96, 103, 119, 130, 131, 132, 133, 139, 140, 141, 142, 143, 144, 148, 157, 158, 159, 161, 163, 174, 175, 177, 187, 190, 191, 195, 196, 197, 199, 201 at 300 ppm gave more than or equal to 70 % control in these tests when compared to the untreated check which showed extensive pathogen growth. 15 Example 5: Phytophthora infestans (Late blight of potato & tomato): The compounds were dissolved in 0.3% dimethyl sulfoxide and then added to Rye Agar medium just prior to dispensing it into petri dishes. 5 mL medium, with the compound in the desired test concentration, was dispensed into a 60 mm sterile petri-plate. After solidification, each plate was seeded with a 5 mm size mycelial disc taken from the periphery of an actively growing virulent culture plate 20 of Phytophthora infestans. The plates were incubated in growth chambers at 18 ºC temperature and 95% relative humidity for seven days and the radial growth was measured and compared to the one of the untreated control. Compounds 36 and 170 at 300 ppm gave more than or equal to 70 % control in these tests when compared to the untreated check which showed extensive pathogen growth. 25 Example 6: Botrytis cinerea (Gray mold): Liquid testing Yeast, bacterial peptone and sodium acetate (YBA) liquid medium containing a BOTRCI (104spores / mL) spore suspension was prepared. For the inhibition assay, each test compound was solved in dimethyl sulfoxide and 100 µl of the respective test solution was given into a well of a 96-well microtiter plate, consequently, the same volume (100 µl) of the media and spore suspension was added to each 30 well to obtain the final test concentration. The plates were incubated at 22 °C for 15-18 days. The growth inhibition was evaluated by measuring the OD600. Percent inhibition was calculated with the below formula: I= (C-B)-(T-B) / (C-B)*100 PI External where T=treatment, C=control, and B=blank Compounds 1, 2, 3, 5, 7, 8, 17, 19, 21, 23, 26, 27, 28, 33, 36, 37, 54, 58, 60, 62, 64, 69, 77, 94, 96, 97, 105, 106, 107, 109, 110, 119, 124, 125, 127, 128, 129, 130, 131, 132, 133, 135, 136, 138, 140, 141, 142, 143, 144, 145, 146, 147, 148, 150, 152, 155, 157, 158, 159, 160, 161, 162, 163, 164, 166, 167, 5 169, 172, 175, 177, 187, 190, 191, 193, 196 at 300 ppm gave more than or equal to 70 % control in these tests when compared to the untreated check which showed extensive pathogen growth Example 7: Fusarium culmorum (Foot rot / Head blight of cereals): Compounds were dissolved in 0.3% dimethyl sulfoxide and then added to Potato Dextrose Agar medium just prior to dispensing it into petri dishes. 5ml medium with compound in the desired 10 concentration was dispensed into 60mm sterile petri-plates. After solidification each plate was seeded with a 5mm size mycelial disc taken from the periphery of actively growing virulent culture plates. Plates were incubated in growth chambers at 25°C temperature and 60% relative humidity for seven days and radial growth was measured. Compounds 1, 2, 7, 8, 21, 23, 26, 27, 32, 37, 47, 58, 103, 119, 125, 128, 130, 131, 133, 140, 141, 142, 15 143, 144, 146, 148, 157, 158, 159, 160, 163, 167, 174, 175, 177, 180, 185, 186, 190, 191, 196, 197 at 300 ppm gave more than or equal to 70 % control in these tests when compared to the untreated check which showed extensive pathogen growth. Example 8: Sclerotinia sclerotiorum (White mold): Compounds were dissolved in 0.3% dimethyl sulfoxide and then added to potato dextrose agar medium 20 just prior to dispensing it into petri dishes. 5 mL medium with the compound in the desired test concentration was dispensed into 60 mm sterile petri-plates. After solidification, each plate was seeded with a 5 mm size mycelial disc taken from the periphery of an actively growing virulent culture plate. Plates were incubated in growth chambers at 20oC temperature and 70% relative humidity for seven days and the radial growth was measured and compared to the one of the untreated control. 25 Compounds 1, 2, 3, 5, 6, 7, 8, 16, 19, 21, 23, 25, 26, 27, 31, 32, 33, 35, 36, 37, 40, 45, 46, 47, 48, 49, 56, 58, 64, 71, 73, 76, 77, 81, 89, 90, 94, 96, 97, 103, 104, 105, 109, 117, 119, 123, 124, 125, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 139, 140, 141, 142, 143, 144, 146, 148, 150, 152, 153, 155, 156, 157, 158, 159, 161, 162, 163, 167, 169, 174, 175, 177, 180, 185, 186, 187, 190, 191, 195, 196, 197, 199, 200, 201, 202, 203 at 300 ppm gave more than or equal to 70 % control in these tests when 30 compared to the untreated check which showed extensive pathogen growth. Example 9: Rhizoctonia solani (Rice sheath blight / Potato black scurf): Compounds were dissolved in 0.3% dimethyl sulfoxide and then added to potato dextrose agar medium just prior to dispensing it into petri dishes. 5 mL medium with a compound in the desired test PI External concentration was dispensed into 60 mm sterile petri-plates. After solidification each plate was seeded with a 5 mm size mycelial disc taken from the periphery of an actively growing virulent culture plate. Plates were incubated in growth chambers at 25 ℃ temperature and 60% relative humidity for seven days and the radial growth was measured and compared to the one of the untreated control. 5 Compounds 8, 26, 130, 131, 143, 196 at 300 ppm gave more than or equal to 70% control in these tests when compared to the untreated check which showed extensive pathogen growth. Example 10: Septoria tritici Potato dextrose (PDB) liquid medium (Difco) containing a Septoria tritici (105 spores / mL) spore suspension was prepared. For the inhibition assay, each test compound was dissolved in dimethyl 10 sulfoxide.100 µL of the test media-solution was added to a 96-well microtiter plate, consequently, the same volume (100 µL) of spore suspension was added to the well making the final test concentrations and the plate was incubated at 18 °C for 15 to 18 days. After the period of incubation, the length of pycnidiospores were measured under a microscope using software for image acquisition and analysis. Then, for each condition of the test, a mean length of pycnidiospores is calculated by averaging the size 15 of pycnidiospores. From this mean length of pycnidiospores, the efficacy (E) of the product for each condition can be calculated by comparison to the mean length of pycnidiospores obtained in the control condition (untreated) according to the formula: E = 100 x [(C-T) / C] C is the mean length of pycnidiospores obtained for the control condition (untreated) and T is the mean 20 length of pycnidiospores for conditions treated with the specific concentration (c) of the fungicide. Compounds 1, 2, 7, 8, 19, 21, 22, 33, 35, 36, 37, 38, 107, 108, 118, 122 at 300 ppm gave more than or equal to 70 % control in these tests when compared to the untreated check which showed extensive disease development. 25 Green House Biological Activity: Example A: Phakopsora pachyrhizi test on soybean plants The compounds were dissolved in 2% dimethyl sulfoxide / acetone and then mixed with water containing emulsifier to the calibrated spray volume of 30 mL. Each spray solution was poured into a spray bottle for further application. 30 To test the preventive activity of the compound, healthy young soybean plants, raised in the greenhouse, were sprayed with the active compound preparation at the stated application rate inside the spray cabinets using hollow cone nozzles. One day after treatment, the plants were inoculated with a conidial suspension containing 2 x105Phakopsora pachyrhizi inoculum. The inoculated plants were then kept in a greenhouse chamber at 22-24 °C temperature and 80-90% relative humidity for disease expression. PI External A visual assessment of the compound’s performance was carried out by rating the disease severity (0- 100% scale) on treated plants 3, 7, 10 and 15 days after application. Efficacy (% control) of the compound was calculated by comparing the disease rating in the treatment with the one of the untreated control. The treated plants were also assessed for plant damage by recording symptoms like necrosis, 5 chlorosis and stunting. Compounds 1, 3, 4, 5, 6, 16, 23, 25, 27, 28, 33, 36, 38, 41, 42, 59, 60, 77, 89, 94, 103, 104, 105, 124, 125, 126 at 500 ppm gave more than or equal to 70 % control in these tests when compared to the untreated check which showed extensive disease development. Example B: Pseudoperonospora cubensis on cucumber plants 10 The compounds were dissolved in 2% dimethyl sulfoxide / acetone and then mixed with water containing emulsifier to the desired test concentration in a calibrated spray volume of 30ml. The test solutions were poured into the spray bottles for further applications. To test the preventive activity of compounds, healthy young cucumber plants, raised in the greenhouse were sprayed with the active compound preparation at the stated application rates 15 inside the spray cabinets using hallow cone nozzles. One day after treatment, the plants were inoculated with a conidial spore suspension containing 2x104Pseudoperonospora cubensis inoculum. The inoculated plants were then kept in a greenhouse chamber at 230C temperature & 80-90 % relative humidity for disease expression. A visual assessment of the performance of the compounds was carried out by rating the disease 20 severity (0-100% scale) on treated plants 3, 7, 10 and 15 days after application. Efficacy (% control) of the compounds was calculated by comparing the disease rating in the treatment with the one of the untreated control. The compounds were also assessed for their plant compatibility by recording symptoms like necrosis, chlorosis and stunting. Compounds 7, 8, 11, 12, 15, 23, 140 at 500 ppm gave more than or equal to 70% control in 25 these tests when compared to the untreated check which showed extensive disease development. Example 12: Septoria nodorum test in wheat The single compounds were dissolved in 2% DMSO / Acetone and then mixed with water containing an emulsifier to a calibrated spray volume of 30 mL. The spray solutions were poured into spray bottles 30 for further applications. PI External To test the preventive activity of the compounds and respective composition, healthy young wheat plants, raised in the greenhouse, were sprayed with the single compound or respective composition at the stated application rates inside the spray cabinets using hollow cone nozzles. One day after treatment, the plants were inoculated with a suspension containing 2.8x106 Septoria nodorum inoculum. The 5 inoculated plants were then kept in a greenhouse chamber at 22-25 °C temperature and 90-100 % relative humidity for disease expression. A visual assessment of the performance of the compounds and the respective composition was carried out by rating the disease severity (0-100% scale) on treated plants 3, 7 and 10 days after application. Efficacy (% control) of the compounds and composition was calculated by comparing the disease rating 10 in the treatment with the one of the untreated, inoculated control plants. The compounds and the respective compositions were also assessed for their plant compatibility by recording symptoms like necrosis, chlorosis & stunting. Compounds 1, 2, 7, 8, 23, 36, 37, 130, 131, 133, 134, 136, 139, 152, 153, 155, 156, 157, 158, 159, 160, 161, 162, 163 at 500 ppm gave more than or equal to 70% control in these tests when compared to the 15 untreated check which showed extensive disease development. Having described the invention with reference to certain preferred embodiments, other embodiments will become apparent to one skilled in the art from the consideration of the specification. It will be apparent to those skilled in the art that many modifications, both to materials and methods, may be practiced without departing from the scope of the invention. 20

Claims

PI External CLAIMS:

1. A compound of formula (I) or an agriculturally acceptable salt, N-oxide, isomer, tautomer or polymorph thereof, 5wherein, D is selected from the group consisting of phenyl or a 5- or 6-membered heteroaryl ring, wherein said 5- or 6-membered heteroaryl ring comprises 1, 2, 3 or 4 heteroatoms each independently selected from N, O, and S(O)0-2, and wherein said phenyl or 5- or 6-membered 10 heteroaryl ring may be further substituted with one or more different or identical substituents selected from R1band / or R1c; R1ais selected from the group consisting of hydrogen, halogen, hydroxyl, cyano, nitro, C1-C6- alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, C3-C8-cycloalkyl, C3-C8-halocycloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C2-C6-alkenyloxy,15 C2-C6-haloalkenyloxy, C2-C6-alkynyloxy, C2-C6-haloalkynyloxy, C3-C6-cycloalkyloxy, C1-C6- alkylthio, C1-C6-haloalkylthio, C3-C6-cycloalkylthio, C1-C6-alkylsulphinyl, C1-C6- haloalkylsulphinyl, C1-C6-alkylsulfonyl, C1-C6-haloalkylsulfonyl, -N(R7)2, -CO-N(R9)2, - S(O)(R8)=NR9, -N=S(O)(R8)2, -P(O)(R8)2, Si(R8)3 or phenyl which may be optionally substituted with one or more different or identical substituents selected from halogen, cyano, 20 C1-C6-alkyl, C1-C6-haloalkyl, C3-C8-cycloalkyl, C1-C6-alkoxy or C1-C6-haloalkoxy; R1bis selected from the group consisting of hydrogen, halogen, hydroxyl, cyano, C1-C6-alkyl, C1-C6-haloalkyl, C3-C8-cycloalkyl, C1-C6-alkoxy and C1-C6-haloalkoxy; R1cis selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C3-C8-cycloalkyl, hydroxyl and cyano; 25 R2is selected from the group consisting of hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6- haloalkyl, C3-C8-cycloalkyl, C1-C6-alkoxy, and C1-C6-haloalkoxy; R3is selected from the group consisting of hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6- haloalkyl, C1-C6-cyanoalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6- haloalkynyl, C3-C8-cycloalkyl, C1-C6-alkoxy, and C1-C6-haloalkoxy;PI External R4is selected from the group consisting of hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6- haloalkyl, C3-C8-cycloalkyl, C1-C6-alkoxy, and C1-C6-haloalkoxy; Z1, Z2and Z3are each independently selected from CR5or N; R5is selected from the group consisting of hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6- 5 haloalkyl, C1-C6-alkoxy and C3-C8-cycloalkyl; B represents a 5-membered aromatic heterocyclic ring, wherein the 5-membered aromatic heterocyclic ring comprises 1 to 4 heteroatoms selected from oxygen, nitrogen or S(O)0-2,wherein the ring B is unsubstituted or substituted with one or more different or identical substituents selected from R6; 10 R6can be selected from the group consisting of hydrogen, halogen, cyano, hydroxyl, C1-C6- alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C3-C8-cycloalkyl, C3-C8-cycloalkyl, C6-C10-aryl which may be substituent with 1 to 2 same or different substitutent selected from the group consisting of C1-C6-alkyl, C1-C6-haloalkyl, halogen, C1-C6-alkoxy and C1-C6- haloalkoxyl, or -N(R7)2; 15 R7represents hydrogen, C1-C6-alkyl, C3-C8-cycloalkyl, C1-C6-alkylcarbonyl, C3-C8- cycloalkylcarbonyl, C1-C6-alkoxycarbonyl or C1-C6-alkylsulfonyl; R8is selected from the group consisting of hydrogen, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C2-C6-alkenyl, C2-C6-haloalkenyl, C2-C6-alkynyl, C2-C6-haloalkynyl, C3-C8-cycloalkyl, C1-C6- alkoxy and C1-C6-haloalkoxy; 20 R9is selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6-haloalkyl and C3-C8- cycloalkyl; R10and R11are independently selected from hydrogen or C1-C6-alkyl or together can form an oxo group (=O) or a 3- to 6-membered carbocyclic ring; R1aand R1boptionally together along with the phenyl or 5- or 6-membered heteroaryl ring may 25 form an 8- to 10-membered bicyclic carbocyclic or heterocyclic ring system that can be optionally substituted with one or more different or identical substituents selected from R1band / or R1c, wherein the bicyclic heterocyclic ring system comprises one or more heteroatoms selected from nitrogen, oxygen or S(O)0-2, and wherein one or more carbon atom of the bicyclic carbocyclic or heterocyclic ring system may be replaced with C(O). 30 2. The compound as claimed in claim 1, wherein the compound of formula (I) is selected from a compound of formula (I-A),PI External, wherein n = 1-3, B, R1a-R1c, R2, R3, R4, R10, R11and Z1-Z3are as defined in claim 1.

3. The compound as claimed in claim 1 or claim 2, wherein the compound is selected from a compound of formula (I-B), 5wherein n = 1-3; B is thiophenyl (thienyl), thiazolyl, isothiazolyl, or thiadiazolyl ring, wherein said ring is unsubstituted or substituted with one or more different or identical substituents selected from R6; and R1a-R1c, R2, R3, R4, R6, R10, R11and Z1-Z3are as defined in claim 1.

4. The compound as claimed in any one of the claims 1-3, wherein 10 R1ais selected from the group consisting of hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6- haloalkyl, C3-C8-cycloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C3-C6-cycloalkyloxy, C1-C6- alkylthio, C1-C6-haloalkylthio, or C1-C6-alkylsulfonyl; R1bis selected from the group consisting of hydrogen, halogen, cyano, C1-C6-alkyl, C1-C6- haloalkyl, and C3-C8-cycloalkyl; 15 R1cis selected from the group consisting of hydrogen, halogen, cyano, C1-C6-alkyl and C1-C6- haloalkyl; R2is hydrogen; R3is selected from the group consisting of hydrogen, halogen or C1-C6-alkyl; R4is selected from the group consisting of hydrogen and C1-C6-alkyl;20 the ring C = is selected from one of the following rings C-1 to C-7:PI Externalwherein R5is independently selected from the group consisting of hydrogen, halogen, C1-C6- alkyl, C1-C6-haloalkyl, and C3-C8-cycloalkyl and R5can be same or different in the C-7 imidazolyl ring; 5 R6is selected from hydrogen, halogen or C1-C6-alkyl; R10and R11are hydrogen, and n is 1-3.

5. The compound as claimed in any one of the claims 1-3, wherein R1ais selected from the group consisting of hydrogen, fluoro, chloro, bromo, iodo, cyano, 10 methyl, ethyl, isopropyl, trifluoromethyl, methoxy, ethoxy, isopropoxy or cyclopropyl; R1bis selected from the group consisting of hydrogen, fluoro, chloro, bromo, cyano, methyl, trifluoromethyl or cyclopropyl; R1cis selected from the group consisting of hydrogen, fluoro, chloro or bromo; R2is hydrogen; 15 R3is selected from the group consisting of hydrogen, chloro or methyl; R4is selected from the group consisting of hydrogen or methyl;wherein R5is independently selected hydrogen, chloro, methyl, ethyl, trifluoromethyl and 20 cyclopropyl;PI External R6is selected from hydrogen, fluoro, chloro, bromo, or methyl; R10and R11are hydrogen, and n is 1-3.

6. A method for preparing the compound of formula (I-A), wherein said method comprising step-i or 5 steps ii-iii or steps iv-v: i. reacting an amine compound of formula 1 with a compound of formula 2 in the presence of an optional coupling / activating agent, base and in a solvent to obtain the compound of formula (I-A), ; 10ii. reacting an amine compound of formula 1 with a compound of formula 10 to obtain a compound of formula 4,iii. reacting the compound of formula 4 with a compound of formula 5 using a transition metal 15 catalyst and a base in a solvent, to obtain the compound of formula (I-A),iv. reacting an amine compound of formula 1 with a compound of formula 6 to obtain a compound of formula 7,PI External; and v. oxidizing the compound of formula 7 in the presence of metal oxide or oxygen atmosphere to obtain the compound of formula (I-A),, 5 wherein R1a-R1c, R2, R3, R4, R10, R11and Z1-Z3are as defined in claim 1.

7. A method for preparing an intermediate compound of formula 15, wherein said method comprising the steps of: a. reacting a compound of formula 10 with tosylmesyl isocyanide and a base in one or more solvent to obtain the compound of formula 10,10 ; b. treating the compound of formula 10 with a compound of formula 12 or formula 14 in the presence of a base and a solvent to obtain the compound of formula 13,; andPI External c. reducing the compound of formula 13 to the compound of formula 15 using a combination of a transition metal salt and sodium borohydride in a solvent,, wherein R2is hydrogen; R3is selected from hydrogen, halogen, or C1-C6-alkyl; R4is C1-C6- 5 alkyl; R6is selected from hydrogen, halogen or C1-C6-alkyl; R12is selected from hydrogen or halogen; and X is selected from Cl, Br, I, tosylate (OSO2-p-tolyl), mesylate (OSO2Me) or triflate (OSO2CF3).

8. A method for preparing a compound of formula (I), wherein the compound of formula (I) is selected from formula (I-D-d) or (I-E-c), said method comprising step-d: 10 d. reacting a compound of formula (15) with a compound of formula 2A in the presence of an optional coupling reagent and in a solvent,, wherein R2, R3, ring C, R6, R12and R1a-R1care as defined in claim 4; and R4is selected from C1-C6-alkyl. 15 9. A composition for controlling or preventing plant fungal diseases, wherein said composition comprising the compound of formula (I) as claimed in claim 1 and an agrochemically acceptable auxiliary.

10. The composition as claimed in claim 9, wherein said composition may further comprises an additional active ingredient selected from fungicide, insecticide, nematicide, acaricide, 20 biopesticide, herbicide, safener, plant growth regulator, antibiotics, fertilizer or nutrients.

11. The composition as claimed in claim 9, wherein said composition is applied to a seed and the amount of the compound of formula (I) as claimed in claim 1 in said composition is ranges from 0.1 gai to 10 kgai per 100 kg of seeds.PI External 12. The composition as claimed in claim 9, wherein the plant fungal disease is caused by rust pathogens selected from the group comprising of Hemileia vastatrix, Uromyces appendiculatus / fabae / phaseoli, Puccinia spp. on various plants, and Phakopsora spp. on various plants. 5 13. The composition as claimed in claim 12, wherein the Puccinia spp. on various plants is selected from P. triticina, P. striiformis, P. Hordei, P. graminis or P. recondita on cereals selected from wheat, barley or rye and Phakopsora spp. on various plants is selected from Phakopsora pachyrhizi and Phakopsora meibomiae on soybeans.

14. A combination comprising the compound of formula (I) as claimed in claim 1 and a pesticidally 10 active substance selected from the group consisting of fungicide, insecticide, nematicide, acaricide, biopesticide, herbicide, safener, plant growth regulator, antibiotic, fertilizer and nutrient.

15. A method for controlling or preventing phytopathogenic fungi, wherein the method comprises treating the fungi or the materials, plants, plant parts, locus thereof, soil or seeds to be protected against fungal attack, with an effective amount of the compound of formula (I) as claimed in claim 15 1 or the composition as claimed in claim 9 or the combination as claimed in claim 14.

16. A method for controlling or preventing infestation of plants by phytopathogenic micro-organisms in agricultural crops and or horticultural crops wherein an effective amount of the compound of formula (I) as claimed in claim 1 or the composition as claimed in claim 9 or the combination as claimed in claim 14, is applied to the seeds of plants. 20 17. A compound of formula (I-C) or an agriculturally acceptable salt, N-oxide, isomer, tautomer or polymorph thereof,Formula (I-C) wherein the compound is selected from: 25 N-(2-(6-chloropyridin-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propyl)-1-(2,4-difluorophenyl)-1H- pyrazole-4-carboxamide; 1-(2-chloro-4-methylphenyl)-N-(2-(6-chloropyridin-2-yl)-2-(1- methyl-1H-pyrazol-4-yl)propyl)-5-(trifluoromethyl)-1H-1,2,3-triazole-4-carboxamide (compound 9); N-(2-(6-chloropyridin-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propyl)-5-methyl-1- (2,4,6-trichlorophenyl)-1H-1,2,3-triazole-4-carboxamide (compound 10); 1-(2-chloro-4-PI External fluorophenyl)-N-(2-(6-chloropyridin-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propyl)-5-ethyl-1H- 1,2,3-triazole-4-carboxamide (compound 11); 1-(2-chloro-4-methylphenyl)-N-(2-(6- chloropyridin-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propyl)-5-methyl-1H-1,2,3-triazole-4- carboxamide (compound 12); 1-(3,5-bis(trifluoromethyl)phenyl)-N-(2-(6-chloropyridin-2-yl)- 5 2-(1-methyl-1H-pyrazol-4-yl)propyl)-1H-1,2,3-triazole-4-carboxamide (compound 13); N-(2- (6-chloropyridin-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propyl)-1-(2,4-dichlorophenyl)-5- (trifluoromethyl)-1H-1,2,3-triazole-4-carboxamide (compound 14); N-(2-(6-chloropyridin-2- yl)-2-(1-methyl-1H-pyrazol-4-yl)propyl)-1-(2,4-dichloro-6-methylphenyl)-5-methyl-1H- 1,2,3-triazole-4-carboxamide (compound 15); 1-(4-chloro-2-fluorophenyl)-N-(2-(6-10 chloropyridin-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propyl)-5-methyl-1H-1,2,3-triazole-4- carboxamide (compound 16); 1-(3-chloro-5-(trifluoromethyl)phenyl)-N-(2-(6-chloropyridin- 2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propyl)-1H-1,2,3-triazole-4-carboxamide (compound 17); 1-(2-chloro-4-fluorophenyl)-N-(2-(6-chloropyridin-2-yl)-2-(1-methyl-1H-pyrazol-4- yl)propyl)-5-cyclopropyl-1H-1,2,3-triazole-4-carboxamide (compound 18); N-(2-(6-15 chloropyridin-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propyl)-1-(2,4-difluorophenyl)-5-methyl- 1H-1,2,3-triazole-4-carboxamide (compound 19); N-(2-(6-chloropyridin-2-yl)-2-(1-methyl- 1H-pyrazol-4-yl)propyl)-1-(2,4-difluorophenyl)-5-methyl-1H-pyrazole-3-carboxamide (compound 25); N-(2-(6-chloropyridin-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propyl)-1-(4- fluorophenyl)-1H-pyrazole-3-carboxamide (compound 26); N-(2-(6-chloropyridin-2-yl)-2-(1- 20 methyl-1H-pyrazol-4-yl)propyl)-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide (compound 28); N-(2-(6-chloropyridin-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propyl)-2-(2-fluorophenyl)- 2H-1,2,3-triazole-4-carboxamide (compound 30); N-(2-(6-chloropyridin-2-yl)-2-(1-methyl- 1H-pyrazol-4-yl)propyl)-2-(4-fluorophenyl)-2H-1,2,3-triazole-4-carboxamide (compound 33); or N-(2-(6-chloropyridin-2-yl)-2-(1-methyl-1H-pyrazol-4-yl)propyl)-2-(2-fluorophenyl)-2H- 25 tetrazole-5-carboxamide (compound 37).

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