3D technology-based neutron capture shielding apparatus and preparation method therefor

Abstract

Disclosed in the present invention are a 3D technology-based neutron capture shielding apparatus and a preparation method therefor, relating to the technical field of radiation protection. The neutron capture shielding apparatus comprises a body surface skin 3D model, a tumor 3D model, and a forming combined mold. The forming combined mold is obtained by injection molding of a basic combined mold. A central hollow structure and an injection hole structure are designed in the basic combined mold. The basic combined mold comprises a neutron irradiation plan navigation guide plate, a skin fit apparatus, a connecting apparatus, and a radioactive source receiving apparatus. One side of the radioactive source receiving apparatus is connected to a neutron radioactive source, and the other side of the radioactive source receiving apparatus is connected to the connecting apparatus. The skin fit apparatus is embedded in the connecting apparatus. The skin fit apparatus is sequentially connected to the neutron irradiation plan navigation guide plate and the tumor 3D model, and is configured for fitting with the body surface skin 3D model. Based on the present invention, an individualized shielding protection apparatus can be designed according to the actual situation of tumor radiotherapy of a patient, and the design is simple and easy to implement.

Description

A neutron capture shielding device based on 3D technology and its preparation method Technical Field

[0001] The present invention relates to the field of radiation protection technology, and more particularly to a neutron capture shielding device based on 3D technology and a preparation method thereof. Background Art

[0002] Neutron capture therapy (NCT) is a dual chemo-radiation cancer treatment method that uses non-radioactive elements ( 10 Neutron capture therapy is a treatment method that uses charged secondary particles produced by neutron capture reactions between gamma-rays (B or Gd) and neutrons to kill cancer cells. Although the neutrons used in neutron capture therapy have a short range, their emission paths are complex and varied. These secondary particles can interact with other normal tissue cells, causing harm to human health and radioactive contamination of the environment. Therefore, effective shielding and protection against neutrons and gamma rays has become a key factor in the new generation of neutron capture therapy.

[0003] Among the existing neutron shielding materials, boron carbide (B4C) has the best neutron shielding performance. 10 The absorption cross section of boron for thermal neutrons is 3837 targets. Boron steel, lead plates and large concrete with boron as the main absorber have been used as the main materials for nuclear protection. Boron-containing polyethylene sheet is the current conventional neutron shielding material. 10 Element B can efficiently absorb low-energy neutrons. However, commercially available boron-polyethylene materials are produced in batches, making them difficult to re-mold into complex components in practical applications. This makes personalized shielding in complex scenarios impossible, resulting in unsatisfactory results.

[0004] Therefore, how to solve the application shortcomings of existing neutron shielding materials and achieve more personalized shielding protection is an urgent problem that technical personnel in this field need to solve. Summary of the Invention

[0005] In view of this, in order to solve the problems in the background technology, the present invention provides a neutron capture shielding device based on 3D technology and a preparation method thereof.

[0006] In order to achieve the above object, the present invention provides the following technical solutions:

[0007] A neutron capture shielding device based on 3D technology, comprising a 3D model of the skin, a 3D model of the tumor, and a molding assembly mold;

[0008] The forming assembly mold is obtained by performing injection molding on the basic assembly mold, and the basic assembly mold is designed with a central hollow and injection hole structure;

[0009] The basic combination mold includes a neutron irradiation planning navigation guide, a skin fitting device, a connecting device, and a radiation source receiving device. One side of the radiation source receiving device is connected to the neutron radiation source, and the other side is connected to the connecting device. A skin fitting device is embedded in the connecting device. The skin fitting device is connected to the neutron irradiation planning navigation guide and the tumor 3D model in sequence for fitting with the 3D model of the skin on the body surface.

[0010] Optionally, the skin fitting device is designed according to the neutron irradiation planning navigation guide, and the body surface skin 3D model, tumor 3D model, and neutron irradiation planning navigation guide are designed as a set, and are designed according to the neutron radiation source and tumor 3D model.

[0011] Optionally, the injection molding process uses a mixture of silicone and silicone curing agent and boron carbide solution, wherein the silicone and silicone curing agent mixed with boron carbide solution are uniformly stirred and mixed in a ratio of boron carbide: silicone: silicone curing agent = 0.1:1:0.1, and heated and dried at 60°C for 12-20 hours.

[0012] Optionally, the skin-fitting device, connecting device, and radiation source receiving device are designed as adjustable replaceable assembly devices.

[0013] Optionally, a lead shielding shell is further provided outside the basic combined mold.

[0014] Optionally, the basic combined mold is made by 3D printing, the printing material is QSY white resin: high-density polyethylene resin, the printing accuracy is: ±0.15 / 100mm, and the minimum wall thickness requirement is: 0.3mm.

[0015] A method for preparing a neutron capture shielding device based on 3D technology comprises the following steps:

[0016] Reconstruct the patient's tumor and skin based on the patient's imaging data;

[0017] Design neutron irradiation plan navigation guide based on the irradiation area centered on the patient's tumor;

[0018] Design skin-fitting device based on neutron irradiation plan navigation guide;

[0019] Based on the neutron radiation source and tumor 3D model, design the connection device and radiation source receiving device to form the basic assembly mold;

[0020] Design the center hollowing and pouring holes of the basic combination mold and perform 3D printing;

[0021] Prepare a boron carbide solution mixed with silicone and silicone curing agent, and perform pouring and drying molding on the basic assembly mold to obtain a molding assembly mold;

[0022] The 3D model of the skin surface, the 3D model of the tumor and the molding combination mold together constitute the neutron capture shielding device.

[0023] From the above technical solutions, it can be seen that the present invention provides a neutron capture shielding device based on 3D technology and a preparation method thereof, which has the following beneficial effects compared with the prior art:

[0024] The present invention can solve the application shortcomings of existing neutron shielding materials, promote the application of 3D technology to the field of neutron radiation protection, overcome the limitations of existing boron-containing polyethylene shielding materials, and design personalized shielding protection devices based on the actual situation of radiotherapy for patient tumors.

[0025] The neutron capture shielding device designed based on the individualized patient tumor shape using the scheme of the present invention is simple and easy to implement, has multiple components and flexible assembly models, can be independently designed and manufactured, can integrate individualization and mass production, and has broad application prospects and economic value. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are merely embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the provided drawings without paying any creative work.

[0027] Figure 1(a) is a schematic diagram of the irradiation navigation guide with the neutron capture shielding device aligned with the patient's irradiation position;

[0028] Figure 1(b) is a schematic diagram of a 3D tumor model with the neutron capture shielding device fitted to the patient's irradiation position;

[0029] FIG2 is a schematic structural diagram of a neutron capture shielding device;

[0030] FIG3 is a schematic diagram of a transmitting source receiving device;

[0031] Figure 4 is a schematic diagram of a connecting device;

[0032] FIG5 is a schematic diagram of a skin-fitting device;

[0033] FIG6 is a schematic diagram of a neutron irradiation plan navigation guide;

[0034] Figure 7 is a schematic diagram of a 3D tumor model;

[0035] FIG8 is a schematic diagram of a 3D model of the skin surface;

[0036] Figure 9(a) is a schematic diagram of the patient's DICOM image data;

[0037] Figure 9(b) is a schematic diagram of a multimodal display of a patient's tumor target area;

[0038] FIG9( c ) is a schematic diagram of the reconstructed patient skin tissue and tumor tissue;

[0039] Figure 10(a) is a schematic diagram of the guide plate planning based on skin and tumor tissue;

[0040] Figure 10(b) is a schematic diagram of the designed neutron irradiation plan navigation guide;

[0041] FIG11( a ) is a CAD black and white line elevation view of the neutron capture shielding device of FIG2 ;

[0042] FIG11( b ) is a CAD black and white line drawing of the neutron capture shielding device of FIG2 ;

[0043] FIG11( c ) is a CAD black and white line drawing of the neutron capture shielding device in FIG2 from another angle;

[0044] FIG11( d ) is a CAD black and white line top view of the neutron capture shielding device in FIG2 ;

[0045] Among them, 1 represents the 3D tumor model, 2 represents the neutron irradiation planning navigation guide, 3 represents the skin fitting device, 4 represents the connecting device, and 5 represents the radiation source receiving device. DETAILED DESCRIPTION

[0046] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0047] 3D printing technology, a representative example of current advanced manufacturing technologies, is widely used in aerospace, defense, military, jewelry, biomedicine, and other fields. Based on medical 3D reconstruction technology, individualized modeling is performed using patient imaging data, enabling the design and production of personalized preoperative models, surgical guides, rehabilitation braces, and more.

[0048] An embodiment of the present invention discloses a neutron capture shielding device based on 3D technology, including a 3D model of the skin on the surface of the body, a 3D model of a tumor 1, and a forming combination mold; the forming combination mold is obtained by perfusion molding the basic combination mold, see Figure 2, Figure 11 (a)-Figure 11 (d) are CAD black and white line schematic diagrams of the neutron capture shielding device.

[0049] Referring to Figure 2, the basic combination mold includes a neutron irradiation planning navigation guide 2, a skin fitting device 3, a connecting device 4, and a radiation source receiving device 5. One side of the radiation source receiving device 5 is connected to the neutron radiation source, and the other side is connected to the connecting device 4. The connecting device 4 is embedded with a skin fitting device 3. The skin fitting device 3 is connected to the neutron irradiation planning navigation guide 2 and the tumor 3D model 1 in sequence for fitting with the 3D model of the skin on the body surface.

[0050] The skin-fitting device 3 is designed based on the positioning and planning of the neutron irradiation planning navigation guide 2 using the 3D tumor model 1. The 3D skin model, 3D tumor model 1, and neutron irradiation planning navigation guide 2 are designed as a set based on Sketch, and are designed based on the neutron radiation source equipment and the 3D tumor model 1.

[0051] The skin-fitting device 3, connecting device 4, and radiation source receiving device 5 are designed as adjustable, interchangeable assemblies. The connecting device 4 is available in various sizes, including 10cm*5cm, 10cm*10cm, 15cm*10cm, 20cm*15cm, and 30cm*20cm. The diameter of the radiation source receiving device 5 can be tailored to the machine model.

[0052] In the specific implementation process, the skin fitting device 3 is 15 cm high, the connecting device 4 is designed according to different models, with a wall thickness of 1 cm and a height of 15 cm, and the radiation source receiving device 5 is set with a diameter according to the machine model, a wall thickness of 1 cm, and a height of 15 cm.

[0053] The basic combined mold is made by 3D printing, and the printing material is QSY white resin: high-density polyethylene resin, the printing accuracy is: ±0.15 / 100mm, and the minimum wall thickness requirement is: 0.3mm.

[0054] During the specific implementation process, considering that neutrons and boron carbide may react to produce a certain amount of secondary gamma rays, a lead shielding shell is provided outside the basic assembly mold, and the thickness of the lead shielding shell can be set to 5-20 mm.

[0055] A central hollow and infusion hole structure is designed in the obtained basic combined mold, and infusion molding is performed using a mixture of silicone and silicone curing agent and a boron carbide solution. The silicone and silicone curing agent are mixed with the boron carbide solution in a ratio of boron carbide: silicone: silicone curing agent = 0.1:1:0.1, and then heated and dried at 60°C for 12-20 hours.

[0056] Another embodiment of the present invention further provides a method for preparing a neutron capture shielding device based on 3D technology, comprising the following steps:

[0057] Reconstruct the patient's tumor and skin: See Figure 9(a) for the patient's DICOM image data, and Figure 9(b) for a multimodal display of the patient's tumor target area. Using mainstream medical 3D reconstruction mimics software, the threshold tool "Thresholding" was used to select appropriate tumor and skin thresholds based on the patient's DICOM image data. The mask segmentation tool "Split Mask" was used to segment the appropriate region of interest. Editing and optimization were performed using tools such as "Edit Mask". Finally, "Caculate 3D from Mask" was used to complete the 3D reconstruction of the tumor and skin, as shown in Figure 9(c).

[0058] Design of neutron irradiation plan navigation guide 2: See Figure 10(a) and Figure 10(b). (1) Design and generation of the bottom surface guide of the sheet: Use the "lasso Area Mark" tool to lasso mark the irradiation area centered on the tumor. The area outline of this area follows the design principles of the radiotherapy plan to achieve optimal radiotherapy shielding. Then copy the marked area to part to separate the sheet that can be edited separately. (2) Optimization of the bottom surface navigation guide: Use "Design" and "Offset, Uniform Offset" to offset the sheet by 5mm to form a closed entity. Use "Trim", "Fix", "Fill Hole Free" and other commands to repair and optimize the design to complete the design of the neutron irradiation plan navigation guide 2.

[0059] Design of skin-fitting device 3: (1) Personalized skin-fitting design: ① Vertical Sketch design and optimization under irradiation viewing angle: Select "Sketch" to build a new design sketch, set up a mask in the vertical direction of the proposed irradiation viewing angle, and build a sketch. According to the relative direction between the neutron irradiation plan navigation guide 2 and the sketch, perform "Align" movement according to the object coordinate system of the neutron irradiation plan navigation guide 2 to separate it from the guide, so as to achieve vertical stretching operation. According to the relative size of the neutron irradiation plan navigation guide 2 and the sketch, perform sketch size design and optimization. ② Personalized design based on the outline planning of the neutron irradiation plan navigation guide 2: Select "Import References to Sketch" in Sketch to select the "outline" of the neutron irradiation plan navigation guide 2 based on the sketch to realize personalized outline planning and display the outline line in a physical form. (2) Design of skin-fitting device 3 based on inner contour line: Design skin-fitting device 3 based on the outline of neutron irradiation plan navigation guide 2 planned in the sketch. Design a regular rectangle based on the sketch, the size of which is required to effectively irradiate the tumor. Based on the inner and outer contour lines, use "Design-Extrude" to expand and stretch 150mm upward in the irradiation direction to form a three-dimensional model. Display the chest model, move the above-mentioned cylindrical model so that it overlaps with the patient contour model, and then use the "Design-Subtraction" tool to Boolean subtract the patient contour from the cylindrical model, thus completing the first part of the personalized irradiation device based on the patient's skin and the contour line of the radiotherapy planning guide.

[0060] Design Connector 4: Different models of Connector 4 were designed based on the tumor's condition and the diameter of the machine's emission source. This device was designed to be reusable and configured to push and pull with the skin-adhesive device 3, ensuring a tight fit based on the sketch design to prevent radiation leakage. Based on the outer contour of the skin-adhesive device 3, the device was offset and expanded outward by 5mm using "Sketch-Tools-Offest." The newly obtained contour and the original outer contour were then subjected to "Design-Extrude," stretching the original contour by 180mm and the newly obtained contour by 150mm. A Boolean operation "Design-Subtraction" was then performed on both to create the middle portion of Connector 4.

[0061] Design the radiation source receiving device 5: Based on the radiation source device, that is, the irradiation equipment model, design a receiving device of the same size as the radiation source with the center of the Sketch as the center of the circle. Use "Design-Extrude" on the sketch to stretch it to a height of 150mm, and use "Sketch-Tools-Offest" on the sketch to offset it inward by 5mm to complete the stretching of the inner cylinder. Use "Align" to move the inner cylinder to 1 / 2 of the outer cylinder. Use the Boolean operation "Design-Subtraction" to realize the shear calculation of the inner and outer cylinders and the connecting device 4, thereby completing the design of the receiving device.

[0062] Design the center hollowing and pouring holes of the basic combination mold: Based on the basic combination mold obtained above, the center hollowing design is designed through Hollow software to enable subsequent pouring, and pouring holes are set at appropriate positions. The diameter of the pouring hole is slightly smaller than the wall thickness and will not cause mold perforation. Multiple pouring holes can be set to facilitate quick pouring.

[0063] 3D printing: The basic combination mold designed above is exported in "STL" format, pre-processed in 3D printing slicing software, the relevant model is repaired, support is generated, and printing is completed in a light-curing printer using QSY white resin material. The printed mold is de-supported, cleaned, polished, and UV-cured. The mold is checked for hollowing and whether the injection holes are unobstructed, etc. 3D printing model quality control.

[0064] A boron carbide solution mixed with silicone and silicone curing agent is prepared, and the basic assembly mold is poured and dried to form a molding assembly mold. The body surface skin 3D model, the tumor 3D model 1 and the molding assembly mold together constitute a neutron capture shielding device.

[0065] Considering the potential for neutrons and boron carbide to react and produce a certain amount of secondary gamma rays, a 5-20mm thick lead shielding shell is designed for the main device. This shielding material is shaped and fixed to the components of the main device, such as the radiation source receiving device 5 and the connecting device 4, to shield impure radiation and gamma rays.

[0066] The device and preparation method of the present invention can be used in neutron capture therapy, and can also be used in other radiotherapy or shielding material design.

[0067] The various embodiments in this specification are described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the various embodiments can be referenced to each other.

[0068] The above description of the disclosed embodiments is intended to enable one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be readily apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention is not limited to the embodiments shown herein but is intended to conform to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A neutron capture shielding device based on 3D technology, characterized in that, It includes a 3D model of the body surface skin, a 3D model of the tumor, and a forming combined mold; The forming combined mold is obtained by perfusion molding of a basic combined mold, and a central hollow and perfusion hole structure is designed in the basic combined mold; The basic combined mold includes a neutron irradiation plan navigation guide plate, a skin fitting device, a connecting device, and a radiation source receiving device. One side of the radiation source receiving device is connected to a neutron radiation source, and the other side is connected to the connecting device. The skin fitting device is embedded in the connecting device, and the skin fitting device is sequentially connected to the neutron irradiation plan navigation guide plate and the tumor 3D model for fitting with the 3D model of the body surface skin.

2. The neutron capture shielding device based on 3D technology according to claim 1, characterized in that The skin fitting device is designed according to the neutron irradiation plan navigation guide plate. The 3D model of the body surface skin, the 3D model of the tumor, and the neutron irradiation plan navigation guide plate are designed as a set, and are designed according to the neutron radiation source and the 3D model of the tumor.

3. A neutron capture shielding device based on 3D technology according to claim 1, characterized in that The process of the perfusion molding uses a mixture of silica gel and silica gel curing agent and boron carbide solution. The mixture of silica gel and silica gel curing agent and boron carbide solution is uniformly stirred and mixed according to the ratio of boron carbide: silica gel: silica gel curing agent = 0.1: 1: 0.1, and is heated and dried at 60 °C. The time of the heating and drying is 12 - 20 h.

4. A neutron capture shielding device based on 3D technology according to claim 1, characterized in that, The skin fitting device, the connecting device, and the radiation source receiving device are designed as adjustable, replaceable, and assembled devices.

5. A neutron capture shielding device based on 3D technology according to claim 1, characterized in that, A lead shielding outer shell is also provided outside the basic combined mold.

6. A neutron capture shielding device based on 3D technology according to claim 1, characterized in that, The basic combined mold is made by 3D printing. The printing material is QSY white resin: high-density polyethylene resin, the printing accuracy is ±0.15 / 100 mm, and the minimum wall thickness requirement is 0.3 mm.

7. A preparation method of a neutron capture shielding device based on 3D technology, characterized in that, It includes the following steps: Reconstruct the patient's tumor and body surface skin according to the patient's imaging data; Design a neutron irradiation plan navigation guide plate according to the irradiation area centered on the patient's tumor; Design a skin fitting device according to the neutron irradiation plan navigation guide plate; Design a connecting device and a radiation source receiving device according to the neutron radiation source and the 3D model of the tumor to form a basic combined mold; Perform a central hollow and perfusion hole design on the basic combined mold and perform 3D printing; Configure a mixture of silica gel and silica gel curing agent and boron carbide solution, perform perfusion and drying molding on the basic combined mold to obtain a forming combined mold; The 3D model of the body surface skin, the 3D model of the tumor, and the forming combined mold together constitute a neutron capture shielding device.

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