Composition for improving skin blood circulation

Abstract

The present disclosure relates to a composition for improving skin blood circulation. The composition for improving skin blood circulation of the present disclosure activates an adenosine receptor when applied to the skin, thereby promoting the formation of new blood vessels and the branching of capillaries, leading to a significant improvement in skin blood circulation. The composition for improving skin blood circulation of the present disclosure has a remarkable synergistic effect on the improvement of skin blood circulation by using as active ingredients: aescin; and panthenol, niacinamide, or a combination of a mixture thereof. The composition for improving skin blood circulation of the present disclosure can be effectively used for improving skin blood circulation, as a skin external preparation, cosmetic composition, or quasi-drug composition targeting skin tissue.

Description

Composition for improving skin blood circulation

[0001] This application claims priority to Republic of Korea Application No. 10-2024-0006084, filed January 15, 2024, the entire disclosure of which is incorporated herein by reference.

[0002] The present disclosure relates to a composition for improving skin blood circulation.

[0003] The skin is a vital organ responsible for various physiological functions, including protecting the body from the external environment, acting as a barrier to prevent the loss of internal moisture and beneficial substances, regulating body temperature, and excreting nutrients. However, skin cell activity can decline and skin condition worsen for the following reasons.

[0004] Collagen and elastin, found in the dermal layer of the skin, play a significant role in skin composition, providing mechanical strength, connective tissue resistance, maintaining tissue cohesion, and supporting cell adhesion. Collagen is depleted by stress, aging, and photoaging caused by UV exposure. Elastin, on the other hand, is known to lose its three-dimensional structure and activity after exposure to UV rays, due to elastase, a degrading enzyme whose activity increases. This loss of collagen and elastin activity can cause skin tissue to become loose and lose elasticity.

[0005] Furthermore, as epidermal cellular function declines, metabolism becomes impeded and dead skin cells may not shed properly. When exposed to UV rays while excessive dead skin cells accumulate, skin elasticity decreases, leading to wrinkles. Furthermore, if a sebum barrier is not formed on the epidermis, moisture and sebum secretion decrease, leading to dryness and the formation of wrinkles.

[0006] Blood circulation refers to the flow of blood through blood vessels to all parts of the body. Blood circulation is influenced not only by physical factors like blood cell count, viscosity, and shear stress, but also by changes in blood lipid composition and blood cells. Poor blood circulation can lead to stiff shoulders and neck, numbness in the extremities, cold hands and feet, and edema in the lower extremities, and can even contribute to cerebral or cardiovascular disease. Furthermore, improving blood circulation in the skin can transform dull, inelastic skin into vibrant, clear, and transparent skin, creating a more radiant, healthy complexion.

[0007] However, existing medications aimed at improving blood flow have side effects such as gastrointestinal upset and elevated blood pressure, making them difficult to take. Therefore, there is a need to develop products using natural ingredients that are safe for the human body with minimal side effects and can fundamentally improve blood flow.

[0008] The problem that the present disclosure seeks to solve is to provide a composition for improving skin blood circulation that is safe for the human body, has no side effects, and has an excellent effect of improving skin blood circulation.

[0009] To solve the above problems, the inventors of the present invention have diligently researched and made efforts to develop a composition that can improve problems such as side effects and precautions for use of conventional skin treatments, and can effectively improve skin blood circulation without the disadvantages such as weak effects of skin improvement agents, while being safe for the human body. As a result, the inventors of the present invention have discovered that although the skin blood circulation improvement effect of panthenol and niacinamide individually was minimal, when escin; and a combination of panthenol, niacinamide, or a mixture thereof was administered (applied) to the skin, skin blood circulation was significantly improved, and surprisingly, the combination of the above ingredients unexpectedly exhibited a remarkable synergistic effect in improving skin blood circulation, thereby completing the present invention.

[0010] The present disclosure provides a composition for improving skin blood circulation, comprising escin, panthenol, niacinamide, or a mixture thereof as active ingredients. This composition for improving skin blood circulation may be a composition for external application to the skin.

[0011] In one aspect of the present disclosure, the panthenol used in the present invention may be d-panthenol.

[0012] In one aspect of the present disclosure, "improving skin blood circulation" may refer to increasing blood flow by facilitating blood circulation in skin blood vessels. This improved skin blood circulation can help improve skin condition to make it more vibrant and healthy.

[0013] In one aspect of the present disclosure, “skin” may mean human tissue composed of a stratum corneum, an epidermis layer, and a dermis layer, and may specifically include the face, ears, scalp, back, palms, soles, etc. depending on the region, and a particularly preferred region may be the scalp.

[0014] In one aspect of the present disclosure, "administering" to the skin may mean introducing the composition for improving skin blood circulation of the present disclosure into the skin via an appropriate method commonly used in the art. The administration route may be any common route as long as it can reach the target tissue. Preferably, the composition may be administered transdermally, and topical application may be preferred. The frequency of application of the composition of the present disclosure may be determined according to prescription or need. The amount of the composition may be appropriately adjusted depending on individual differences such as age or lesion, or the formulation, and may typically be applied to the skin once or several times a day in an appropriate amount for use for one week to several months. In Experimental Example 2 of the present disclosure, it was confirmed that an excellent skin blood circulation effect was observed after use of the composition for improving skin blood circulation.

[0015] In one aspect of the present disclosure, the composition for improving skin blood circulation may contain escin, panthenol, or niacinamide in an amount of 0.00001 to 50 wt%, preferably 0.0001 to 5 wt%, based on the total weight of the composition. When the components are used within the above range, the effect is excellent and the composition may be preferable in terms of formulation stability.

[0016] In one aspect of the present disclosure, the composition for improving skin blood circulation may include all of escin, panthenol, and niacinamide, and the weight ratio of escin:panthenol:niacinamide may be 1:0.1 to 400:0.1 to 400, preferably 1:0.5 to 300:0.5 to 300, and more preferably 1:1 to 200:1 to 200 (escin:panthenol:niacinamide). When the three components are included in the weight ratio, the effect of improving skin blood circulation is remarkably excellent, and this is specifically described in the skin blood circulation improvement effect experiment of Experimental Example 2.

[0017] In one aspect of the present disclosure, the external skin composition for improving skin blood circulation of the present disclosure may be a solid, semi-solid, or liquid external skin composition. The external skin composition may be a formulation prepared by mixing an active ingredient with various carriers such as fats, petrolatum, lanolin, or glycerol so that it can be easily applied to the skin. The formulation of the external skin composition is not particularly limited, but may be a powder, gel, ointment, cream, liquid, or aerosol.

[0018] In one aspect of the present disclosure, the composition for improving skin blood circulation of the present disclosure may be a cosmetic composition or a quasi-drug composition. The cosmetic composition may include conventional adjuvants in the cosmetic field, such as fatty substances, organic solvents, solubilizers, thickeners, gelling agents, emollients, antioxidants, suspending agents, stabilizers, foaming agents, fragrances, surfactants, water, ionic or non-ionic emulsifiers, fillers, sequestering agents, chelating agents, preservatives, vitamins, blocking agents, humectants, essential oils, dyes, pigments, hydrophilic or lipophilic active agents, or lipid vesicles. In addition, the cosmetic composition of the present disclosure may be used as a component of general cosmetics or functional cosmetics together with other adjuvants conventionally used in the fields of cosmetology or dermatology.

[0019] In addition, the present disclosure can provide a functional cosmetic comprising the cosmetic composition. The functional cosmetic is a product having specialized functionality with an emphasis on physiologically active effects, and may include a product that helps whiten the skin, a product that helps improve skin wrinkles, or a cosmetic that helps gently tan the skin or protect the skin from ultraviolet rays. The functional cosmetic of the present disclosure can exhibit a skin improvement effect through the effect of promoting the synthesis of functional substances such as collagen, elastin, laminin, or HAS2. The formulation of such functional cosmetics is not particularly limited, but may be manufactured in the form of, for example, a solution, an emulsion, a suspension, a paste, a cream, a lotion, a gel, a powder, a spray, a surfactant-containing cleanser, an oil, a soap, a liquid detergent, a bath agent, a foundation, a makeup base, an essence, a toner, a foam, a pack, an softener, a sunscreen cream, or a sun oil. Preferably, the functional cosmetic can be manufactured in the form of a skin ointment, emollient toner, nourishing toner, nourishing cream, massage cream, essence, pack, emulsion, or oil gel.

[0020] In one aspect of the present disclosure, the quasi-drug composition for improving skin blood circulation according to the present disclosure may further include, in addition to the above-mentioned effective ingredient, a pharmaceutically acceptable carrier, excipient, or diluent, as needed. The pharmaceutically acceptable carrier, excipient, or diluent is not limited as long as it does not impair the effect of the composition of the present disclosure, and may include, for example, fillers, extenders, binders, wetting agents, disintegrants, surfactants, lubricants, sweeteners, fragrances, or preservatives. Representative examples of pharmaceutically acceptable carriers, excipients or diluents include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, maltitol, starch, gelatin, glycerin, gum acacia, alginate, calcium phosphate, calcium carbonate, calcium silicate, cellulose, methyl cellulose, microcrystalline cellulose, polyvinyl pyrrolidone, water, methyl hydroxybenzoate, propyl hydroxybenzoate, talc, magnesium stearate, mineral oil, propylene glycol, polyethylene glycol, vegetable oil, injectable esters, withepsol, macrogol, Tween 61, cacao butter, or lauric acid. The above-mentioned pharmaceutical composition may include, but is not limited to, a disinfectant, a shower foam, an ointment, a wet tissue, or a coating agent, and the method of formulation, dosage, method of use, components, etc. of the above-mentioned pharmaceutical composition may be appropriately selected from conventional techniques known in the art.

[0021] The present disclosure also provides a method for improving skin blood circulation, comprising applying to the skin a composition comprising escin, panthenol, niacinamide, or a combination thereof. The contents of the composition for improving skin blood circulation can be equally applied to the method.

[0022] In addition, the present disclosure provides a method for promoting skin penetration of a drug or substance using a combination of escin and panthenol, niacinamide, or a mixture thereof. The method may include the steps of (s1) preparing a composition comprising a desired substance together with a combination of escin and panthenol, niacinamide, or a mixture thereof; and (s2) applying the composition comprising the substance to the skin. Any substance that does not decrease its original activity when used together with escin, panthenol, or niacinamide may be used. The substance may be, but is not limited to, a physiologically active protein.

[0023] In one aspect of the present disclosure, the composition used in the method may be appropriately selected in dosages of the active ingredient or excipient depending on the patient. The composition may include a physiologically acceptable medium, which may include, but is not limited to, an aqueous or hydro-alcoholic solution, a water-in-oil emulsion, an oil-in-water emulsion, a microemulsion, an aqueous gel, anhydrous gel, serum, a dispersion of vesicles, or a powder. The term "physiologically acceptable" means that the composition is suitable for topical or transdermal use when in contact with a mucous membrane, appendage (nails, hair), or skin of a mammal, particularly a human. A composition including a physiologically acceptable medium can be ingested or injected into the skin without toxicity, incompatibility, instability, allergic reaction, or other risks.

[0024] In one aspect of the present disclosure, the topical skin preparation for improving skin circulation according to the present disclosure can be combined with other active ingredients that can act synergistically or additionally to enhance the desired effects described herein. Such active ingredients can include anti-aging, anti-fine lines and wrinkles, whitening, pre-pigmentation, hydrating, humectant, moisturizing, slimming, exfoliating, anti-acne, anti-redness, anti-inflammatory, anti-oxidant / radical scavenger, complexion whitening, anti-glycation, volumizing, reconstructing, anti-carbonylation, skin softening, anti-hair regrowth, action on the stratum corneum, dermal-epidermal adhesion, HSP protein production, firmness, elasticity and skin tone, hair growth (eyelashes and eyebrows), eye contouring (dark circles and under-eye bags), blood circulation promotion, or vitamin preparations.

[0025] All ingredients described in this disclosure preferably do not exceed the maximum usage levels stipulated in relevant laws and regulations of Korea, China, the United States, Europe, Japan, etc. (e.g., Regulations on Cosmetic Safety Standards (Korea), or Cosmetic Safety Technical Standards (China)). That is, preferably, the external skin preparation, cosmetic, or quasi-drug composition according to this disclosure contains the ingredients according to this disclosure within the content limits permitted by the relevant laws and regulations of each country.

[0026] When the composition for improving skin blood circulation of the present disclosure is applied to the skin, adenosine receptors are activated, thereby promoting the creation of new blood vessels and branching of capillaries, thereby significantly improving skin blood circulation.

[0027] The composition for improving skin blood circulation of the present disclosure has a remarkable synergistic effect on improving skin blood circulation by combining the active ingredient escin; and panthenol, niacinamide, or a mixture thereof.

[0028] The composition for improving skin blood circulation of the present disclosure can be effectively used as a skin external preparation, cosmetic composition, or quasi-drug composition targeting skin tissue for the purpose of improving skin blood circulation.

[0029] Hereinafter, the present invention will be described in detail, using examples and the like, to aid understanding. However, the examples according to the present invention may be modified in various different forms, and the scope of the present invention should not be construed as being limited to the following examples. The examples of the present invention are provided to more fully explain the present invention to those of average skill in the art.

[0030]

[0031] Manufacturing Example: Cosmetic composition for improving skin blood circulation (skin lotion)

[0032] A skin lotion was prepared using escin, panthenol, niacinamide, or a mixture of two or more selected thereof as active ingredients in a conventional manner according to the prescription described in Table 1 below.

[0033] Ingredients Number Cetostearyl Alcohol Stearyl Chloride Triethyl Ammonium Hydroxyethyl Cellulose Essin Panthenol Niacinamide Flavoring and Color Purified Water Comparative Example 1220.5000 Quantity Residual Amount (Total 100) Comparative Example 200.20.1 Comparative Example 300.10.2 Comparative Example 40.00100 Example 10.0010.20 Example 20.00100.2 Example 30.0010.20.1 Example 40.0010.10.2 Comparative Example 50.12 Comparative Example 60.21 Comparative Example 70.200 Example 50.212 Example 60.221 Comparative Example 80.500 Example 70.512 Example 80.521 Comparative Example 9100 Embodiment 9120 Embodiment 10102 Embodiment 11112 Embodiment 12121

[0034]

[0035] Experimental Example 1: Effect of regulating angiogenesis-promoting signals (adenosine receptor pathway)

[0036] Adenosine receptor pathway signals, which are generally activated in vascular cells, play a key role in the formation of new blood vessels and the branching of capillaries. Therefore, this experiment examined how the combination of the present invention's escin and panthenol, niacinamide, or a mixture thereof contributes to the amplification of adenosine receptor pathway signals.

[0037] NECA was used as a positive control to amplify adenosine receptor pathway signals, and DMSO was used as a negative control. 3x10 CREB Reporter HEK293A cells were cultured in a 96-well plate. 4 After seeding each well, the dogs were treated with the escin, panthenol, niacinamide, or a mixture thereof according to the present invention at the treatment concentrations listed in Table 2 below. Reporter analysis was performed using the Luciferase assay kit (E1960) from Promega. The analysis was performed according to the manufacturer's experimental method, and adenosine receptor activity was measured using a luminometer Victor (PerkinElmer, Waltham, Massachusetts, USA).

[0038] Treatment group Treatment concentration Adenosine receptor signaling activation ability to promote blood flow (%) Untreated group -100.0% NECA 100 μM 420.8% Essin 30 μg / ml 372.4% Panthenol 30 μg / ml 101.1% Niacinamide 30 μg / ml 106.3% Essin + Panthenol 15 μg / ml + 15 μg / ml 492.0% Essin + Niacinamide 15 μg / ml + 15 μg / ml 399.9% Essin + Panthenol + Niacinamide 10 μg / ml + 10 μg / ml + 10 μg / ml 507.7%

[0039] As shown in the experimental results described in Table 2 above, when Escin and panthenol, niacinamide, or a mixture thereof were combined, the activity of the adenosine receptor signaling system, one of the main targets for improving blood flow, was significantly increased. Through this, it was confirmed that Escin and panthenol, niacinamide, or a mixture thereof had a remarkably excellent effect on improving blood flow.

[0040]

[0041] Experimental Example 2: Effect of a composition for improving skin blood circulation (skin lotion) on improving skin blood circulation

[0042] The skin blood circulation improvement effect of the composition for improving skin blood circulation of the present disclosure was tested on a total of 36 men and women. Using Comparative Examples 1 to 9 and Examples 1 to 12 described in Table 1 above, the skin blood circulation improvement efficacy test of each composition was conducted.

[0043] The test sequence for the composition for improving skin blood circulation was divided into 15-minute intervals: before and after skin application. Furthermore, during the human application test period, the use of any cosmetics containing active ingredients that could influence the test results (e.g., functional cosmetics for whitening or wrinkle improvement) other than the test composition was prohibited.

[0044] To measure the improvement in skin blood flow, the skin was washed and left for 10 to 15 minutes under constant temperature and humidity conditions (25°C, 40% relative humidity). Measurements were made around the hairline between the forehead and scalp using a Periflux System 5000 (Perimed, Jarfalla, Sweden). The compositions of the examples were applied to the measurement area and measurements were made 15 minutes later. This experiment was repeated three times, and the average value was calculated. The change in skin blood flow after use compared to before use was indicated. The measurement results are shown in Table 3 below.

[0045] Treatment group Skin blood flow number Material concentration Skin blood flow change rate (%) Essin Panthenol Niacinamide Comparative example 100099.8% Comparative example 200.20.1102.2% Comparative example 300.10.2100.8% Comparative example 40.00100120.7% Example 10.0010.20127.0% Example 20.00100.2129.1% Example 30.0010.20.1134.6% Example 40.0010.10.2131.5% Comparative example 5012103.4% Comparative example 6021101.9% Comparative example 70.200125.1% Example 50.212137.6% Example 60.221132.9%Comparative Example 80.500135.2%Example 70.512165.8%Example 80.521154.4%Comparative Example 9100148.6%Example 9120162.3%Example 10102168.5%Example 11112197.0%Example 12121170.1%

[0046] In view of the above results, it was confirmed that the skin blood circulation improvement effect was remarkably excellent in Examples 1 to 12 containing escin; and panthenol, niacinamide, or a mixture thereof. Through this, it was confirmed that the skin blood circulation improvement composition of the present disclosure containing escin; and panthenol, niacinamide, or a mixture thereof as active ingredients can be very effectively used to promote skin blood circulation.

[0047] In the above experimental example, the composition for improving skin blood circulation according to the present disclosure was prepared in the form of a skin lotion, and the skin blood circulation-improving effect was confirmed. However, this formulation example is merely one example of the composition for improving skin blood circulation according to the present disclosure, and it will be apparent to those skilled in the art that the scope of the composition of the present disclosure is not limited to the formulation alone.

Claims

1. A cosmetic composition for improving skin blood circulation, comprising escin; and panthenol, niacinamide, or a mixture thereof as active ingredients.

2. In the first paragraph, the cosmetic composition is a cosmetic composition for improving skin blood circulation that activates adenosine receptor signals.

3. A cosmetic composition for improving skin blood circulation, characterized in that the cosmetic composition in claim 1 is for improving scalp blood circulation.

4. A cosmetic composition for improving skin blood circulation, wherein the escin, panthenol, or niacinamide is contained in an amount of 0.00001 to 50 wt% based on the total weight of the composition in paragraph 1.

5. In the first paragraph, the composition is a cosmetic composition for improving skin blood circulation, which contains all of escin, panthenol, and niacinamide.

6. A cosmetic composition for improving skin blood circulation in the fifth paragraph, wherein the weight ratio of escin, panthenol, and niacinamide is 1:0.1 to 400:0.1 to 400 (escin:panthenol:niacinamide).

7. A pharmaceutical composition for improving skin blood circulation, comprising escin, panthenol, niacinamide, or a mixture thereof as active ingredients.