Tooth whitening composition

Abstract

Provided according to an embodiment of the present invention is a liquid composition for tooth whitening, which comprises sodium metaphosphate and sodium fluoride (NaF), and has a pH of 4 to 6. The liquid composition for tooth whitening according to the present invention can provide excellent whitening effects while reducing oral irritation.

Description

Composition for teeth whitening

[0001] The present invention relates to a tooth whitening composition, and more particularly, to a tooth whitening composition capable of providing a tooth whitening effect with excellent whitening effect while reducing irritation in the oral cavity.

[0002]

[0003] A bright, white smile greatly contributes to confident interpersonal relationships. Furthermore, a confident smile creates a more positive first impression. Recently, with growing interest in teeth whitening beyond oral health, toothpaste formulations with teeth whitening effects are being released.

[0004] Teeth whitening is a dental treatment that whitens and brightens the color of teeth without damaging teeth that have become discolored due to various reasons. Recently, teeth whitening products that can be used at home have been developed.

[0005] There are various types and methods of teeth whitening, but most utilize high-concentration hydrogen peroxide to oxidize and whiten teeth. This method has been used in dentistry for over 100 years, and its whitening effects have been proven. Peroxides, such as hydrogen peroxide, act as oxidizing agents, altering or decomposing tooth discoloration to remove it, achieving tooth whitening. However, their high reactivity limits their storage. Furthermore, the oxidation reaction using peroxide is highly irritating, causing strong irritation when it comes into contact with the lips, gums, or tongue.

[0006] For this reason, active research is being conducted on sodium metaphosphate as an excellent ingredient for removing and preventing discoloration instead of peroxide. However, as the content of sodium metaphosphate increases, there is a problem that it causes irritation to the oral mucosa due to its unique astringent effect. In addition, pyrophosphate is also effective in removing discoloration, but depending on the type, if the pH conditions and dosage are not appropriate, there was a problem that the whitening effect was reduced, and the inherent sour taste deteriorated the usability.

[0007] Against this backdrop, the inventors of the present invention have conducted extensive research to solve the above-mentioned problems, and as a result, have derived the appropriate content of sodium hexametaphosphate and sodium acid pyrophosphate and the appropriate pH for the best whitening effect, thereby confirming the effect of improving whitening efficiency while reducing oral irritation and not reducing the feeling and satisfaction of use, and have completed the present invention.

[0008]

[0009] The present inventors have confirmed that a tooth whitening composition containing sodium hexametaphosphate and sodium acid pyrophosphate has the effect of improving whitening efficiency while reducing oral irritation and not reducing the feeling and satisfaction of use, and have completed the present invention.

[0010]

[0011] An object of the present invention is to provide a hypoallergenic liquid composition for tooth whitening comprising sodium hexametaphosphate, sodium fluoride (NaF), and sodium acid pyrophosphate.

[0012]

[0013] The liquid composition for tooth whitening according to the present invention has an excellent effect of removing staining components while causing less oral irritation and providing an excellent feeling of use.

[0014]

[0015] The liquid composition for tooth whitening according to the present invention has an excellent effect of removing staining components while causing less oral irritation and providing an excellent feeling of use.

[0016]

[0017] According to one embodiment of the present invention, a liquid composition for tooth whitening is provided, which comprises sodium metaphosphate and sodium fluoride (NaF) and has a pH of 4 to 6.

[0018] In addition, according to one embodiment of the present invention, a liquid composition for tooth whitening is provided, wherein the sodium metaphosphate includes sodium hexametaphosphate (SHMP), and the sodium hexametaphosphate (SHMP) is included in a ratio of 1 wt% to 3.5 wt% based on the total weight of the liquid composition for tooth whitening.

[0019] In addition, according to one embodiment of the present invention, a liquid composition for tooth whitening is provided, wherein the sodium fluoride (NaF) is included in a ratio of 0.01 wt% to 0.33 wt%, specifically 0.02 wt%, based on the total weight of the liquid composition for tooth whitening.

[0020] In addition, according to one embodiment of the present invention, a liquid composition for tooth whitening is provided, wherein an anionic surfactant or an amphoteric surfactant is further included in a ratio of 0.01 wt% or more and less than 1.5 wt% based on the total weight of the liquid composition for tooth whitening.

[0021] In addition, according to one embodiment of the present invention, a liquid composition for tooth whitening is provided, wherein the anionic surfactant includes sodium lauryl sulfate (SLS) or an amino acid-based surfactant, and the amphoteric surfactant includes cocamidopropyl betaine (CAPB).

[0022] Additionally, according to one embodiment of the present invention, a liquid composition for tooth whitening further comprising sodium acid pyrophosphate (SAPP) is provided.

[0023] In addition, according to one embodiment of the present invention, a liquid composition for tooth whitening is provided, wherein the sodium acid pyrophosphate (SAPP) is included in a ratio of 0.05 wt% to 0.45 wt% relative to the total weight of the liquid composition for tooth whitening.

[0024] In addition, according to one embodiment of the present invention, a liquid composition for tooth whitening further comprising zinc gluconate is provided.

[0025] In addition, according to one embodiment of the present invention, a liquid composition for tooth whitening is provided, wherein the zinc gluconate is included in a ratio of 0.1 wt% to 0.3 wt% relative to the total weight of the liquid composition for tooth whitening.

[0026] In addition, according to one embodiment of the present invention, a liquid composition for tooth whitening is provided, wherein the liquid composition for tooth whitening further includes at least one component selected from the group consisting of a humectant, a flavoring agent, a sweetener, a preservative, a binder, a foaming agent, a whitening agent, a fragrance, and a pigment.

[0027] In addition, according to one embodiment of the present invention, a liquid composition for tooth whitening is provided, which does not contain hydrogen peroxide.

[0028] In addition, according to one embodiment of the present invention, a liquid composition for tooth whitening is provided, which does not contain tetrasodium pyrophosphate (TSPP).

[0029] Additionally, according to one embodiment of the present invention, a tooth whitening product comprising the liquid composition for tooth whitening is provided.

[0030] In addition, according to one embodiment of the present invention, a tooth whitening product is provided, wherein the tooth whitening product is one selected from the group consisting of a liquid toothpaste, an oral spray, a mouthwash, an oral ointment, a mouthwash, and a gargling product.

[0031]

[0032] This is explained in detail as follows. Meanwhile, each description and embodiment disclosed in the present invention can also be applied to each other description and embodiment. In other words, all combinations of the various elements disclosed in the present invention fall within the scope of the present invention. Furthermore, the scope of the present invention should not be considered limited by the specific descriptions described below.

[0033] All ingredients described in the present invention preferably do not exceed the maximum usage levels specified in the Regulations on Cosmetic Safety Standards, etc. (Korean Regulations), Cosmetic Safety Technical Standards (Chinese Regulations), etc.

[0034] In the present invention, tooth whitening may mean removing a substance that causes a staining effect by attaching to or penetrating the tooth surface and enamel or modifying the chemical structure of the substance to remove the staining effect.

[0035] Additionally, in the present invention, the term "liquid composition" may refer to a composition provided in liquid form, containing water. Accordingly, those skilled in the art can add water to obtain a desired weight of the liquid composition for tooth whitening. The total weight of the composition used to describe the weight ratio of the liquid composition for tooth whitening described below refers to the weight of the composition with water added.

[0036] In addition, in the present invention, oral irritation may include all irritation phenomena, including swelling, redness, pain, etc., that may occur in teeth and gums due to the activation of a tooth whitening ingredient, particularly peroxide.

[0037] In addition, in the present invention, relief means that oral irritation, etc., as described above, is reduced or alleviated, and can be understood as a broad concept including improvement, prevention, treatment, etc.

[0038]

[0039] According to one embodiment of the present invention, a liquid composition for tooth whitening is provided, which comprises sodium metaphosphate and sodium fluoride (NaF) and has a pH of 4 to 6.

[0040] In the present invention, sodium metaphosphate generally refers to a compound represented by the molecular formula of (NaPO3)n. When sodium metaphosphate is included, it can be superior in the effect of removing staining components compared to other polyphosphates and can prevent staining. The sodium metaphosphate can include sodium hexametaphosphate (SHMP). Sodium hexametaphosphate (SHMP) can prevent staining by pushing out and removing staining substances on the tooth surface and then adsorbing to the tooth surface to block the staining substances. Although phosphates including sodium metaphosphate have been known for whitening-related uses, there have been problems in that they can cause a decrease in whitening efficacy, a decrease in usability, and oral irritation if the pH and dosage are not appropriate for the type. However, in one embodiment of the present invention, it was confirmed that sodium hexametaphosphate (SHMP) is superior in the effect of removing staining components and preventing staining while being less irritating compared to other phosphates.

[0041] The above sodium hexametaphosphate (SHMP) may be included in a ratio of 1 wt% to 3.5 wt%, specifically 1 wt% to 3.0 wt%, more specifically 1.5 wt% to 2.5 wt%, and most specifically 2 wt%, based on the total weight of the liquid composition for tooth whitening. When sodium hexametaphosphate (SHMP) is added to the liquid composition for tooth whitening in the above content ratio, the oral irritation may be reduced while the stain removal efficiency may be excellent.

[0042]

[0043] In the present invention, sodium fluoride (NaF) can help prevent tooth decay by forming a film on the tooth surface, preventing tooth decay caused by acid produced by cariogenic bacteria, and inhibiting the enzymatic action of bacteria. Therefore, when sodium fluoride (NaF) is included in a liquid tooth whitening composition, it can have effects such as strengthening tooth structure and increasing acid resistance.

[0044] In addition, the sodium fluoride may be included in a ratio of 0.01 wt% to 1.0 wt%, specifically 0.01 wt% to 0.5 wt%, more specifically 0.01 wt% to 0.4 wt%, more specifically 0.01 wt% to 0.33 wt%, and most specifically 0.01 wt% to 0.03 wt%, based on the total weight of the liquid composition for tooth whitening. By including sodium fluoride in the above-described range, the caries prevention effect can be enhanced.

[0045]

[0046] In the present invention, the pH of the liquid composition for tooth whitening may be 4 to 6, specifically 4 to 5.5, and more specifically 4 to 5. The liquid composition for tooth whitening of the present invention may have the best discoloration removal effect in the above pH range. In particular, the discoloration component removal effect and discoloration prevention effect of sodium hexametaphosphate (SHMP) included in the liquid composition for tooth whitening may be maximized in the above pH range. In the above pH range, the sodium ions or hydrogen ions of sodium hexametaphosphate (SHMP) have a strong affinity for calcium ions exposed on the tooth surface, so that they attach to the tooth enamel surface, destroy the pellicle on the enamel, push out and remove discolored contaminants, and form a sodium hexametaphosphate coating film on the tooth surface, thereby having an excellent effect of preventing new exogenous discoloration. Therefore, an appropriate pH environment is required for an appropriate binding force with metal ions. For example, when the pH of the liquid composition for teeth whitening is lower than 4, sodium hexametaphosphate (SHMP) may be decomposed, reducing the active ingredient that exerts the whitening effect, thereby reducing the ability of sodium hexametaphosphate (SHMP) to bind to metal ions, and when the pH of the liquid composition for teeth whitening is higher than 6, the binding of sodium hexametaphosphate (SHMP) may be inhibited due to increased competition for metal ions, so the whitening effect may be best within the pH range described above.

[0047] In addition, in order to implement a pH buffering system and maintain the pH of the formulation at 4 to 6, a pH adjuster may be additionally included. The pH adjuster is characterized by including one or more of citric acid, sodium citrate, tartaric acid, sodium tartrate, phosphoric acid, sodium phosphate, calcium lactate, sodium phosphate monobasic, sodium phosphate tribasic, potassium phosphate monobasic, potassium phosphate tribasic, sodium bicarbonate, potassium pyrophosphate, etc. The pH adjuster may be included in an amount of 0.01 wt% to 2.0 wt%, preferably 0.01 wt% to 1.0 wt%, and more preferably 0.01 wt% to 0.5 wt%, based on the total weight of the entire liquid composition for tooth whitening. If the pH adjuster of the composition is used in an amount of 0.01 wt% or less, a pH buffering effect cannot be expected, and if the content of the pH adjuster exceeds 2 wt%, a deterioration in usability may occur.

[0048]

[0049] In addition, according to one embodiment of the present invention, an anionic surfactant or an amphoteric surfactant may be further included in a proportion of 0.01 wt% or more and less than 4 wt%, specifically 0.01 wt% or more and less than 3 wt%, more specifically 0.01 wt% or more and less than 2 wt%, and most specifically 0.01 wt% or more and less than 1.5 wt%, based on the total weight of the liquid composition for tooth whitening.

[0050] The anionic surfactant is mainly a sulfate-based, glutamic acid-based, or taurine-based surfactant, and may include sodium lauryl sulfate (SLS), sodium myristoyl glutamate, sodium cocoyl glutamate, sodium methyl cocoyl glutamate, sodium methyl cocoyl taurate (SMCT), or an amino acid-based surfactant other than glutamic acid-based and taurine-based surfactants, preferably sodium lauryl sulfate (SLS) or an amino acid-based surfactant, and more preferably sodium lauryl sulfate (SLS) or sodium methyl taurate (SMCT). In addition, the amphoteric surfactant may include cocamidopropyl betaine (CAPB).

[0051] The above term surfactant is a component characterized by having both hydrophobic and hydrophilic properties in a single molecule, and is an component that effectively removes organic substances contaminated with oily foods, etc., and helps clean the pellicle. In the case of sodium hexametaphosphate, it has a high affinity for calcium ions present on the tooth surface, so it forms a coating film on the tooth surface. However, if there are organic contaminants, it acts to prevent effective contact with the tooth surface. Therefore, if a surfactant is used to remove them, the stain removal and suppression effect can be increased. Since surfactants have an affinity for contact with the oral mucosa as well as the tooth surface, using an excessive amount of 3.0 wt% or more can cause oral irritation. Therefore, when a surfactant is included in the above-mentioned range, the stain removal and suppression effect can be increased without oral irritation.

[0052] In addition, when the anionic surfactant and the amphoteric surfactant are included together, the functional group corresponding to the cation and the anionic part of the anionic surfactant form a complex through their combination, thereby offsetting the irritation caused by the ion interacting with the oral mucosa, thereby preventing irritation and excessive foaming, thereby providing excellent user satisfaction and increasing the efficiency of removing discoloration.

[0053]

[0054] Additionally, according to one embodiment of the present invention, the liquid composition for tooth whitening may further include sodium acid pyrophosphate (SAPP).

[0055] Additionally, according to one embodiment of the present invention, the liquid composition for tooth whitening may not contain tetrasodium pyrophosphate (TSPP).

[0056] When pyrophosphate is included in a tooth whitening composition, it can form a complex with metal ions that cause staining on the tooth surface, thereby increasing the tooth whitening effect. Sodium pyrophosphate, a type of pyrophosphate commonly used, has a pH of about 10, and a tooth whitening composition containing sodium pyrophosphate may generally have a relatively high pH. In contrast, the tooth whitening composition according to the present invention contains sodium metaphosphate and is provided to have a pH of 4 to 6, thereby enhancing the effect of removing staining substances. Therefore, when sodium pyrophosphate is used, the pH of the tooth whitening composition may increase, which may reduce the tooth whitening effect. At this time, when a large amount of acidic substances such as phosphoric acid / citric acid is used to lower the pH of the tooth whitening composition while using sodium pyrophosphate, the tooth whitening composition may have a sour taste, which may reduce the usability. For example, when using Tetrasodium Pyrophosphate (TSPP), it may be difficult to achieve a pH range of 4 to 6, and accordingly, when the content of phosphoric acid / citric acid is increased, a strong sour taste may be induced, which may significantly reduce the usability, and the overall teeth whitening function may also be reduced.

[0057] According to one embodiment of the present invention, by using sodium pyrophosphate as acid sodium pyrophosphate (SAPP), the amount of citric acid or phosphoric acid used to lower the pH can be reduced. This can prevent a sour taste, thereby increasing whitening efficacy without compromising usability.

[0058] Additionally, according to one embodiment of the present invention, the sodium acid pyrophosphate (SAPP) may be included in a ratio of 0.1 wt% to 0.45 wt% relative to the total weight of the liquid composition for tooth whitening. When the sodium acid pyrophosphate (SAPP) is added in the above-described range, the sour taste of the raw material itself may be prevented from being felt, thereby improving the usability of the product.

[0059]

[0060] Furthermore, according to one embodiment of the present invention, a liquid tooth whitening composition further comprising zinc gluconate may be provided. When zinc gluconate is included, the composition can inhibit the growth of harmful bacteria in the oral cavity, thereby preventing dental plaque formation and bad breath. In addition, a protective film can be formed on the tooth surface to protect against external stimuli. Furthermore, when zinc gluconate is included according to one embodiment of the present invention, the bad breath suppression effect can be enhanced compared to when zinc gluconate is included alone. Therefore, the zinc gluconate utilized in one embodiment of the present invention can exhibit an excellent bad breath reduction effect without affecting the whitening effect of a composition comprising sodium metaphosphate and sodium fluoride.

[0061] In addition, according to one embodiment of the present invention, the zinc gluconate may be included in a ratio of 0.1 wt% to 0.3 wt%, specifically 0.1 wt% to 0.25 wt%, more specifically 0.1 wt% to 0.2 wt%, and most specifically 0.15 wt%, relative to the total weight of the liquid composition for tooth whitening.

[0062]

[0063] In addition, according to one embodiment of the present invention, a liquid composition for tooth whitening may be provided, which further includes at least one component selected from the group consisting of a humectant, a flavoring agent, a solubilizer, a sweetener, a preservative, a foaming agent, a fragrance, a pigment, etc.

[0064] Additionally, according to one embodiment of the present invention, an abrasive that is not suitable for application to a liquid formulation because it is not normally dissolved or solubilized in water but simply dispersed may not be included.

[0065] A humectant is a component that prevents the toothpaste from drying out and maintains a moist state. The humectant may include, but is not limited to, any one selected from the group consisting of polyethylene glycol, glycerol, propylene glycol, ethylene glycol, polypropylene glycol, sorbitol, and mixtures thereof. Preferably, it may include any one selected from the group consisting of polyethylene glycol 200 to 600, glycerol, propylene glycol, ethylene glycol, polypropylene glycol, and mixtures thereof. Preferably, petroleum oil, animal or vegetable oil, synthetic lubricant, etc. may be used as a liquid humectant, and most preferably, a liquid polyol may be used in terms of the stability of the composition and excellent usability. Alternatively, the humectant is not limited to a liquid polyol, but may also include a high molecular weight polyol, such as polyethylene glycol or polypropylene glycol, which can exist in a solid state at room temperature due to the intramolecular interaction of polymers when the molecular weight is above a certain level, but can be liquefied by controlling the manufacturing temperature and can be manufactured into a product and maintained in a stable state.

[0066] Solubilizers are used to help dissolve ingredients that do not readily dissolve in water. Examples of solubilizers include liquid olive oil, polysorbate, and PEG-40 hydrogenated castor oil.

[0067] Flavoring agents remain in the mouth and continuously release a fragrance, providing a lasting freshness and helping to eliminate bad breath. Flavoring agents include mints like peppermint and spearmint, wintergreen, methyl salicylate, eugenol, melon, strawberry, orange, and vanillin.

[0068] Sweeteners can be added to overcome the basic taste of the formulation. Sweeteners can play a role in maintaining saliva production by providing a persistent taste while remaining in the oral cavity. Sweeteners include one or a mixture of two or more of saccharin, sucralose, sugar, xylitol, sorbitol, lactose, mannitol, maltitol, erythritol, aspartame, taurine, saccharin salts, D-tryptophan, stevioside, and enzyme-modified stevia.

[0069] Preservatives that can be used include benzoic acid, methylparaben, propylparaben, and sodium benzoate.

[0070] Surfactants can be used to improve usability and aid in cleansing.

[0071] The above-mentioned humectants, flavoring agents, sweeteners, preservatives, binders, surfactants, fragrances, and pigments can be determined in content and type by considering their effect on phosphate.

[0072] Additionally, according to one embodiment of the present invention, the liquid composition for tooth whitening may not contain hydrogen peroxide.

[0073]

[0074] Furthermore, according to one embodiment of the present invention, a tooth whitening product comprising the liquid composition for tooth whitening is provided. The formulation of the tooth whitening product manufactured using the liquid composition for tooth whitening of the present invention can be manufactured using a method commonly used in the industry. The tooth whitening product of the present invention may be in the form of a liquid, solid, suspension, gel, or aerosol, but is not limited thereto.

[0075] In addition, according to one embodiment of the present invention, a tooth whitening product is provided, characterized in that the tooth whitening product has at least one formulation selected from the group consisting of liquid toothpaste, oral spray, oral cleaner, oral hygiene product, and gargling product.

[0076] In order to apply the tooth whitening product of the present invention, appropriate additives, carriers, etc. may be additionally included in the liquid composition for tooth whitening, and a person having ordinary knowledge in the art may appropriately select and combine the additives, carriers, etc.

[0077]

[0078] The tooth whitening composition according to one embodiment of the present invention has been described above. Below, the advantageous effects of the present invention will be confirmed based on manufacturing examples and experimental results of tooth whitening compositions according to Examples and Comparative Examples.

[0079]

[0080] Manufacturing Example 1. Manufacturing of Examples 1 to 15 and Comparative Examples 1 to 8

[0081] The toothpaste compositions of Examples 1 to 15 were prepared with the ingredients and composition ratios shown in Table 1 below.

[0082] Specifically, a mouthwash was prepared by sufficiently stirring the fragrance, ethanol, and solubilizer to solubilize them, then adding the remaining ingredients and stirring for approximately 30 minutes. Poloxamer or HCO-40 was used as the solubilizer.

[0083]

[0084]

[0085] In addition, except for the inclusion or content of sodium metaphosphate, the inclusion or content of sodium acid pyrophosphate (SAPP), the inclusion or content of tetrasodium pyrophosphate (TSPP), and the inclusion or content of a surfactant, the gargle compositions of Comparative Examples 1 to 8 were prepared using the same method as in the preparation of the above examples, with the ingredients and composition ratios shown in Table 2 below.

[0086]

[0087] Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Comparative Example 7 Comparative Example 8 NaF 0.020.020.020.020.020.020.020.02 Glycerin 66666666 Ethanol 7777777 Fragrance 0.220.220.220.220.220.220.220.22 Phosphoric Acid 0.010.140.080.060.20.40.04 0.12 Sodium citrate 0.2 0.0 1 ...

[0088]

[0089] Experimental Example 1. In vitro whitening effect measurement

[0090] In order to confirm the discoloration removal effect of the composition according to the present application, a method was conducted to confirm how much of the discoloration substance was removed when the toothbrush of each example and comparative example was used after the discoloration of the teeth occurred due to the discoloration substance.

[0091] Specifically, specimens were prepared using artificial enamel powder (hydroxyapatite; HAP) and then colored using Stookey's method. The initial L, a, and b values ​​of the colored HAP specimens were measured using a colorimeter, and the lightness values ​​were distributed so that there was no significant difference among the experimental groups. The colored specimens were added to 15 mL of gargle solution and stirred at 300 rpm for 30 minutes at approximately 37°C. After the specimens were sufficiently dried, the chromaticity was measured using a colorimeter and compared with the initial value, and the color change (ΔE) was analyzed.

[0092] In-vitro whitening evaluation, a higher ΔE value indicates a greater effect in removing staining substances.

[0093]

[0094] Experimental Example 2. Evaluation of Satisfaction with Stimulus and Usability

[0095] To confirm the effect of the composition according to the present application on improving the stimulation and usability, 20 volunteers were asked to use the mouthwashes of each example and comparative example at sufficient intervals of 3 days, and then a questionnaire was administered to evaluate their satisfaction with the stimulation and usability. Each mouthwash was used at least twice a day, in an amount of approximately 20 mL, for 1 minute.

[0096] Specifically, each applicant was provided with a toothbrush composition manufactured in the above manufacturing example and allowed to use it. Then, the applicant was asked to express on a 5-point scale whether he or she felt any irritation when using it and how satisfied he or she was with the feeling of use.

[0097] The closer the stimulation evaluation is to 5 points, the higher the stimulation, and the closer the usability satisfaction evaluation is to 5 points, the higher the usability satisfaction.

[0098]

[0099] The results of Experimental Examples 1 and 2 and the pH of each composition are shown in Tables 3 and 4 below. Figure 1 is a graph showing the values ​​of color change analyzed to confirm the whitening effect of the examples and comparative examples of the present application.

[0100]

[0101] Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 Example 9 Example 10 Example 11 Example 12 Example 13 Example 14 Example 15 △E121913292213142527163030303032 Irritation 2.22.52.53.52.52.62.62.63.333.13.23.23.12.6 Satisfaction with use 3.13.83.32.93.43.13.34.12.83.143.83.73.84 pH 446446644644444

[0102] Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Comparative Example 7 Comparative Example 8 △E6 35 28 23 3 2 4 6 1 Stimulation 2.5 4.5 3.7 24.3 2.7 2.5 3.1 Satisfaction with use 31.5 1.7 2.5 1.9 1.3 3 pH 7 444446 4

[0103] Referring to Tables 1 to 4 and Fig. 1, it can be seen that Examples 1 to 4 using 1 to 3 wt% of sodium metaphosphate (SHMP) have superior color removal effects compared to Comparative Example 4 not using sodium metaphosphate (SHMP).

[0104] In addition, compared to Comparative Example 1 with a pH of 7, Examples 1 to 3 with a relatively low pH exhibited excellent discoloration removal effects, and better results were obtained as the pH decreased. Comparative Example 5, which used 4 wt% of sodium metaphosphate (SHMP), showed an increased discoloration removal effect, but it was confirmed that the irritation also increased significantly, making it unsuitable.

[0105] Through this, it can be confirmed that the liquid composition for tooth whitening contains sodium metaphosphate in an amount of 1 to 3.5 wt% based on the total weight of the liquid composition for tooth whitening, and has an excellent stain removal effect and low irritation under conditions where the pH is within 4 to 6.

[0106]

[0107] In addition, in the case of Examples 5 to 10, in which 0.05 to 0.45 wt% of sodium acid pyrophosphate (SAPP) was added, it was confirmed that the color removal effect was further increased. In the case of Comparative Example 3, in which the content of sodium acid pyrophosphate (SAPP) was high, the satisfaction with the feel of the product was low, because the characteristics of the raw material showing a sour taste also affected the product.

[0108] Therefore, it was confirmed that sodium acid pyrophosphate (SAPP) helps remove tooth stains, but if the content is high, the characteristic sour taste becomes an unfavorable factor in the usability, so it is desirable to limit the content to 0.45 wt% or less.

[0109]

[0110] In addition, Example 11, which used sodium lauryl sulfate (SLS), an anionic surfactant, showed the best color removal effect. This is thought to be because the color removal effect was enhanced by the cleansing power of sodium lauryl sulfate (SLS). However, in Comparative Example 2, which used 0.4 wt% of sodium lauryl sulfate (SLS), the satisfaction level was very low due to the irritation and excessive foaming caused by sodium lauryl sulfate (SLS), so it was confirmed that it is desirable to use less than 0.4 wt% of sodium lauryl sulfate (SLS).

[0111] Additionally, the results of Example 13, which used only 0.3 wt% of the anionic surfactant sodium methyl cocoyl taurate (SMCT), and Example 14, which used only 1.0 wt% of the amphoteric surfactant cocamidopropyl betaine (CAPB), were similar to those of Example 11, whereas Example 15, which used a combination of anionic and cationic surfactants, showed the lowest irritation and the best performance. In other words, the highest color removal ability, low irritation, and good satisfaction were confirmed.

[0112]

[0113] In addition, Comparative Example 6, which replaced sodium acid pyrophosphate (SAPP) with tetrasodium pyrophosphate (TSPP) and lowered the pH to 4, also had very low satisfaction with the feel of the product. This is because when tetrasodium pyrophosphate (TSPP) is included, the pH is approximately 10, and the content of citric acid or phosphoric acid increases to lower the pH to 4, which increases the sour taste.

[0114] In addition, in Comparative Example 7, where sodium acid pyrophosphate (SAPP) was replaced with tetrasodium pyrophosphate (TSPP) and the pH was lowered to 6, the effect was lower compared to the same amount of sodium acid pyrophosphate (SAPP). Therefore, it was confirmed that the use of tetrasodium pyrophosphate (TSPP) in a liquid composition for tooth whitening is not desirable in terms of usability and effect.

[0115]

[0116] Additionally, in the case of Example 12, in which zinc gluconate was added, it was confirmed that the tooth whitening effect was maintained at a similar level compared to Example 11.

[0117]

[0118] Experimental Example 3. Clinical Evaluation of Bad Breath

[0119] In order to confirm the bad breath removal effect of the composition according to the present application, a clinical evaluation of bad breath was performed before and after use of the mouthwashes of Examples 11 and 12 according to the present application and the mouthwashes of Comparative Examples 4 and 8.

[0120] Specifically, the initial bad breath level was measured using sensory evaluation and instrumental method (Halimeter) in a fasting state for healthy people who self-perceived bad breath. Fasting state means that the participants brushed their teeth with their usual product 12 hours prior to the visit and visited the morning of the test without brushing their teeth. They also abstained from all food, drink, smoking, water, and oral hygiene practices until the bad breath measurement. Afterwards, each experimental participant was asked to mix approximately 10-15 mL of mouthwash well for 30 seconds and use it. Bad breath 30 minutes to 1 hour after use was measured using the same method as before use. Oral gas was collected for approximately 30 seconds with a sterile syringe in the mouth, and 1 cc of gas was sampled and measured using a gas chromatograph.

[0121] The sensory evaluation was conducted on a 5-point scale, with 5 points indicating very strong bad breath, and the bad breath evaluation unit was measured in ppb.

[0122] The results of Experimental Example 3 are shown in Table 5 below.

[0123]

[0124] Sensory evaluation (intensity, 0-5)*Average Halimeter Before use After 30 minutes After 1 hour Before use After 30 minutes After 1 hour Comparative example 44.43.43.8368335397 Comparative example 84.33.33.5355200219 Example 114.23.23.5327193218 Example 124.32.73.134592109

[0125] Referring to Table 5, it can be confirmed that Example 11 according to the present application has an excellent bad breath removal effect by suppressing volatile sulfur compounds.

[0126] In addition, in the case of Comparative Example 8, which used zinc gluconate alone, a similar level of bad breath removal effect was shown as in Example 11, but in the case of Example 12, in which zinc gluconate was included in the combination of liquid compositions for whitening according to the present application, it was confirmed that the bad breath reduction effect was significantly increased.

[0127]

[0128] From the above description, those skilled in the art will understand that the present invention can be implemented in other specific forms without altering its technical spirit or essential characteristics. In this regard, it should be understood that the embodiments described above are illustrative in all respects and not restrictive. The scope of the present invention should be interpreted as encompassing all changes or modifications derived from the meaning and scope of the following claims and their equivalent concepts, rather than the detailed description above.

Claims

1. Contains sodium metaphosphate and sodium fluoride (NaF), A liquid composition for teeth whitening, having a pH of 4 to 6.

2. In paragraph 1, The above sodium metaphosphate includes sodium hexametaphosphate (SHMP), A liquid composition for tooth whitening, wherein the sodium hexametaphosphate (SHMP) is included in a ratio of 1 wt% to 3.5 wt% relative to the total weight of the liquid composition for tooth whitening.

3. In paragraph 1, A liquid composition for tooth whitening, wherein the sodium fluoride (NaF) is included in a ratio of 0.01 wt% to 0.33 wt% relative to the total weight of the liquid composition for tooth whitening.

4. In paragraph 1, A liquid composition for tooth whitening, wherein an anionic surfactant or an amphoteric surfactant is further included in a ratio of 0.01 wt% to less than 3.0 wt% based on the total weight of the liquid composition for tooth whitening.

5. In paragraph 4, The above anionic surfactant includes sodium lauryl sulfate (SLS) or an amino acid-based surfactant, The above amphoteric surfactant includes cocamidopropyl betaine (CAPB), A liquid composition for tooth whitening, wherein the sodium lauryl sulfate (SLS) is contained in an amount of less than 0.4 wt% based on the total weight of the liquid composition for tooth whitening.

6. In paragraph 1, A liquid composition for tooth whitening, further comprising sodium acid pyrophosphate (SAPP).

7. In paragraph 6, A liquid composition for tooth whitening, wherein the above sodium acid pyrophosphate (SAPP) is included in a ratio of 0.05 wt% to 0.45 wt% relative to the total weight of the liquid composition for tooth whitening.

8. In paragraph 1, A liquid composition for teeth whitening, further comprising zinc gluconate.

9. In paragraph 8, A liquid composition for tooth whitening, wherein the zinc gluconate is contained in a ratio of 0.1 wt% to 0.3 wt% relative to the total weight of the liquid composition for tooth whitening.

10. In paragraph 1, A liquid composition for tooth whitening, wherein the liquid composition for tooth whitening further comprises at least one component selected from the group consisting of a humectant, a flavoring agent, a sweetener, a preservative, a binder, a foaming agent, a whitening agent, a fragrance, and a pigment.

11. In paragraph 1, A liquid composition for teeth whitening, wherein the liquid composition for teeth whitening does not contain hydrogen peroxide.

12. In paragraph 1, A liquid composition for tooth whitening, wherein the liquid composition for tooth whitening does not contain tetrasodium pyrophosphate (TSPP).

13. A tooth whitening product comprising the tooth whitening liquid composition of paragraph 1.

14. In paragraph 13, The above teeth whitening product is any one selected from the group consisting of toothpaste, oral spray, mouthwash, oral ointment, mouthwash, and gargling product.

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