laryngoscope

Abstract

A laryngoscope, including: an elongated body having a long axis, a distal section, and a proximal section, wherein a wall of the elongated body defines and surrounds a working channel having at least one proximal opening at the proximal section, and at least one distal opening at the distal section; at least one optics channel positioned within the working channel, wherein the optics channel has at least one distal visualization aperture facing the distal opening of the working channel, and at least one proximal opening; at least one distal optics assembly, comprising at least one distal camera, positioned within the at least one optics channel and proximally to the distal opening of the working channel, to have a field of view (FOV) between the distal visualization aperture and the working channel distal opening, wherein the at least one camera is configured to acquire an image of the FOV.

Description

[0001] LARYNGOSCOPE

[0002] RELATED APPLICATION / S

[0003] This application claims the benefit of priority from Israeli Patent Application No. 312164 filed on 9 April 2024, the contents of which are incorporated herein by reference in their entirety.

[0004] FIELD AND BACKGROUND OF THE INVENTION

[0005] The present invention, in some embodiments thereof, relates to a working channel device for visualizing and / or accessing objects within the working channel and / or outside the working channel, and more particularly, but not exclusively, to a laryngoscope for visualizing and / or accessing tissue of the throat.

[0006] Direct laryngoscopy (DL) surgeries are performed routinely for the diagnoses and treatment of lesions in the larynx and hypopharynx. The surgeries are most commonly performed under general anesthesia and with intubation. The patient lies in a supine position with head extension. A dental guard is inserted into the mouth and placed over the upper teeth. In order to reach a direct vision of the deeper parts of the pharynx / larynx, a rigid, metal round tube (laryngoscope) with a light source is inserted through the mouth of the patient.

[0007] During surgery, the laryngoscope is directed down the throat until a good visualization of the lesion is achieved. To achieve visualization of the operating field, the surgeon has to look into the laryngoscope. After the laryngoscope is fixed in place, a surgical microscope is placed in front of the patient's head so that the microscope is focused on the tissue at the distal end of the laryngoscope. In DL operations, the distance between the Ocular and the Object is around 400mm. The surgeon sits with his eyes in approximation to the eyepieces (Ocular) of the microscopes. The surgical instruments are inserted into the laryngoscope by the nurse.

[0008] During surgery, surgeons use chairs with handles. Otherwise, the hands get easily tired and it is challenging to maintain stability and control tremors during lengthy procedures. During all the DL procedures, the surgeon is dependent on the help of the assisting nurse. The nurse directs the requested instrument to the hand of the surgeon on one side. The other side of the instrument is directed to the proximal entrance of the laryngoscope, while the eyes of the surgeon are all the time fixed to the eyepieces of the microscope.

[0009] U.S. Patent Application Publication Number US20130172676A1 describes “there is provided a tip section of a multi-camera endoscope, the tip section comprising a unitary fluid channeling component adapted to channel fluid for insufflations and / or irrigation, the unitary fluid channeling component comprising: a proximal opening adapted to receive a fluid tube, the proximal opening being in fluid flow connection with a front fluid (I / I) channel and a side fluid channel” (Abstract).

[0010] Chinese Patent Application Publication Number CN112107286A describes “a low- damage and easier-exposure Al visual voice broadcasting laryngoscope comprises a bottom part, a laryngoscope handle and a top part in sequence from bottom to top, wherein the top part is provided with a display screen, the laryngoscope handle is connected with the top part through a rotating shaft, an accommodating space is arranged in the laryngoscope handle, an Al chip set and a ROM are arranged in the accommodating space, the Al chip set comprises a central processing unit, a pressure sensor chip, a radar ranging sensor chip and an image processing chip, a first database, a second database and a pressure data threshold value are arranged in the ROM, oral cavity structure data for correctly placing the laryngoscope into each position point on a path are stored in the first database, oral cavity images for exposure of the laryngoscope are stored in the second database, the oral cavity structure data stored in the first database and the oral cavity images stored in the second database are in one-to-one correspondence, the bottom part is provided with a base and a lens movable assembly, the base is connected with the lens movable assembly through the, the front end of the base is provided with a radar probe and a camera, and a pressure sensor is arranged in the base” (Abstract).

[0011] Chinese Patent Application Publication Number CN207882558U describes “the utility model discloses a kind of fiber optic endoscope that easy plug is replaceable ; The technical issues of solution : Insertion section in integrally-built fiber optic endoscope mentioned in the background art includes object lens and optical fiber, it is relative to the whole more fragile flimsy part of fiber optic endoscope, sterilizing operation repeatedly had not only been likely to cause the damage of insertion section to influence the use of fiber optic endoscope, but also there is technical issues that disinfection is not thorough and cause cross-infection. The technical solution of use : A kind of fiber optic endoscope that easy plug is replaceable, the encapsulation part being inserted into including insertion section and for insertion section, insertion section includes image-carrying fiber bundle, the first Optic transmission fiber beam and object lens, and encapsulation part includes encapsulation part shell, sealing plate, two limiting locking devices, the second Optic transmission fiber beam, optical-fiber channel pipe, light source and CCD camera. The junction of advantage, this endoscope, insertion section and encapsulation part is easy pulling / inserting structure, and insertion section can be replaced by plug operation” (Machine translation of abstract). U.S. Patent Application Publication Number US20200367738A1 describes “An imaging medical instrument such as an endoscope, an exoscope or microscope having a shaft, in which an optical fiber bundle extends from the proximal to the distal end for illuminating field and in which a lens system is arranged for transmitting an image of the field. A light source inputs coupling light into the one proximal end of the optical fiber bundle with a multiplicity of selectively actuatable individual light sources arranged in an array-like manner, with a camera for capturing the transmitted image of the field of view and with a control unit for selectively actuating the individual light sources of the light source for adapting the illumination field. Here, the illumination field has a different form to the field of view. The control unit has an apparatus for analyzing the illumination situation, the apparatus being suitable and provided for analyzing the image captured by the camera in respect of changes depending on the selectively actuated individual light sources and for analyzing the field of view relative to the illumination field”.

[0012] SUMMARY OF THE INVENTION

[0013] The following describes some examples of embodiments of the invention. Some examples of the invention are described herein (an embodiment may include features from more than one example and / or fewer than all features of an example):

[0014] Example 1. A laryngoscope device, comprising: an elongated rigid body having a distal end shaped and sized to penetrate into a throat of a subject, and a proximal end shaped and sized to be positioned outside the throat, wherein a wall of the elongated rigid body defines and surrounds a working channel having at least one proximal opening at the proximal end, and at least one distal opening; at least one visualization aperture in the working channel, wherein the at least one visualization aperture is located between the proximal opening and the distal opening of the working channel, the at least one visualization aperture faces the at least one distal opening of the working channel; at least one distal optics assembly comprising at least one optic sensor, wherein the at least one optics assembly is positioned at least partly within the at least one visualization aperture.

[0015] Example 2. A device according to example 1, wherein the at least one visualization aperture is located at a distance of at least 0.5 cm from the distal opening of the working channel.

[0016] Example 3. A device according to any one of examples 1 or 2, wherein the at least one distal optics assembly extends out from the at least one visualization aperture into the working channel. Example 4. A device according to example 3, wherein the at least one distal optics assembly extends to a distance of less than 5 cm from the at least one visualization aperture into the working channel.

[0017] Example 5. A device according to any one of examples 3 or 4, comprising at least one extension adjuster configured to adjust an extension distance of the at least one distal optics assembly into the working channel and / or to lock the at least one optics assembly in a target extension distance.

[0018] Example 6. A device according to any one of the previous examples, wherein the at least one distal optics assembly is positioned at least partly within the at least one visualization aperture and / or is oriented relative to the working channel to have a field of view (FOV) within the working channel between the at least one optic sensor and the distal opening of the working channel.

[0019] Example 7. A device according to any one of the previous examples, wherein the at least one distal optics assembly is integrated with the elongated rigid body.

[0020] Example 8. A device according to example 7, wherein the at least one distal optics assembly is fixedly attached to the elongated rigid body.

[0021] Example 9. A device according to any one of examples 1 to 7, wherein the at least one distal optics assembly is configured to be assembled to the elongated rigid body.

[0022] Example 10. A device according to example 9, wherein the at least one distal optics assembly and / or the elongated rigid body comprising at least one fastener configured to fasten the at least one optics assembly to the elongated rigid body.

[0023] Example 11. A device according to any one of the previous examples, wherein the at least one visualization aperture is located at a distal end of at least one first visualization channel located at least partly within the working channel .

[0024] Example 12. A device according to example 11, wherein the at least one first visualization channel has a proximal opening in a wall of the elongated rigid body.

[0025] Example 13. A device according to example 11, wherein the at least one first visualization channel extends out from the elongated rigid body.

[0026] Example 14. A device according to example 13, wherein the at least one first visualization channel comprises a proximal opening located in a side external surface of the elongated rigid body or outside the elongated rigid body at a distance form the external surface. Example 15. A device according to any one of examples 11 or 12, wherein the visualization channel extends proximally towards the elongated rigid body proximal end, along a long axis of the elongated rigid body.

[0027] Example 16. A device according to any one of the previous examples, wherein the at least one distal optics assembly comprises at least one illumination source.

[0028] Example 17. A device according to example 16, wherein the at least one illumination source comprises a light emitting diode (LED) lamp.

[0029] Example 18. A device according to any one of the previous examples wherein the at least one distal optics assembly comprises an endoscope having a body terminating with the at least one optics sensor.

[0030] Example 19. A device according to any one of the previous examples, wherein the at least one optics assembly comprises electrical wiring connected to the at least one optic sensor.

[0031] Example 20. A device according to any one of the previous examples, wherein the at least one visualization aperture comprises at least two spaced apart visualization apertures in the working channel wall facing the working channel lumen, the at least two spaced-apart visualization apertures are positioned between the distal end and the proximal end of the elongated rigid body. Example 21. A device according to example 20, wherein the at least one distal optics assembly comprises at least two distal optics assemblies, wherein each of the at least two distal optics assemblies is positioned at least partly in a different visualization aperture of the at least two visualization apertures.

[0032] Example 22. A device according to example 21 wherein optic sensors of the at least two distal optic assemblies are positioned to have a shared FOV within the working channel.

[0033] Example 23. A device according to any one of examples 20 to 22, wherein the at least two visualization apertures are located at a similar axial distance from the elongated rigid body distal end and / or from the elongated rigid body proximal end.

[0034] Example 24. A device according to any one of examples 20 to 22, wherein the at least two visualization apertures are located at a different axial distance from the elongated rigid body distal end and / or from the elongated rigid body proximal end.

[0035] Example 25. A device according to any one of examples 20 to 24, wherein the at least two visualization apertures are positioned on a circumference of the working channel.

[0036] Example 26. A device according to any one of examples 20 to 25, wherein an angular distance between the at least two spaced apart visualization apertures is equal or shorter than half of a circumference of the working channel. Example 27. A device according to any one of the previous examples, comprising a communication circuitry functionally coupled to the at least one optics assembly, wherein the communication circuitry is configured to generate wireless signals based on signals received from the at least one optics assembly.

[0037] Example 28. A device according to any one of the previous examples, comprising at least one additional proximal optics assembly positioned within the working channel between the proximal opening of the working channel the and the at least one visualization aperture or the at least one distal optics assembly, wherein the at least one proximal optics assembly comprises at least one optic sensor positioned to have a FOV between the at least one proximal optics assembly and the distal opening of the working channel.

[0038] Example 29. A device according to example 28, wherein the at least one proximal optics assembly is located at a distance smaller than 5 cm from the proximal opening of the working channel.

[0039] Example 30. A device according to any one of examples 28 or 29, wherein the at least one proximal optics assembly and the at least one distal optics assembly are positioned within the working channel at opposite sides of the working channel or at an angular distance therebetween which is shorter than a half of a circumference of the working channel.

[0040] Example 31. A device according to any one of the previous examples, comprising an elongated handle coupled or integrated with the elongated body, wherein the handle is shaped to allow holding of the handle within a palm of a hand of a human subject, wherein an end of the elongated handle contacts the elongated body at a distance shorter than 20 cm from the proximal end of the elongated body.

[0041] Example 32. A device according to any one of the previous examples, wherein the laryngoscope or a portion thereof is disposable.

[0042] Example 33. A laryngoscope device, comprising: an elongated body having a distal end shaped and sized to be positioned within a throat of a subject, and a proximal end shaped and sized to be positioned outside the throat, wherein a wall of the elongated body defines and surrounds a working channel having at least one proximal opening at the proximal end, and at least one distal opening; a single visualization channel positioned at least partly within the working channel, wherein the visualization channel has at least one distal visualization aperture facing a distal opening of the working channel, and at least one proximal opening; at least one optic fiber camera within the visualization channel positioned to have a first field of view (FOV) between the at least one distal visualization aperture and the working channel distal opening, to acquire a three dimensional (3D) image of the first FOV, and to transmit the 3D image to a display device an elongated handle coupled or integrated with the elongated body, wherein the handle is shaped to allow holding of the handle within a palm of a hand of a human subject, wherein an end of the elongated handle contacts the elongated body at a distance shorter than 20 cm from the proximal end of the elongated body.

[0043] Example 34. A device according to example 33, wherein the laryngoscope device or a portion thereof is disposable.

[0044] Example 35. A device according to any one of examples 33 or 34, wherein the at least one distal visualization aperture is located at a distance shorter than 15 cm from the distal opening of the working channel.

[0045] Example 36. A device according to any one of examples 33 to 35, wherein the single visualization channel is coupled to the wall of the elongated body and / or defined by the wall, and wherein the distal visualization aperture is positioned on a virtual plane crossing the elongated body and the handle.

[0046] Example 37. A device according to any one of examples 33 to 36, wherein the laryngoscope comprises at least one proximal optics assembly positioned within the working channel at a distance shorter than 10 cm from the working channel proximal opening, wherein the at least one proximal optics assembly is positioned to have a second FOV between the optics assembly and the working channel distal opening, and to acquire an image of the second FOV.

[0047] Example 38. A laryngoscope device, comprising: an elongated rigid body having a distal end shaped and sized to penetrate into a throat of a subject, and a proximal end shaped and sized to be positioned outside the throat, wherein a wall of the elongated rigid body defines and surrounds a working channel having at least one proximal opening at the proximal end, and at least one distal opening; at least one distal optics assembly positioned within the working channel at a distance shorter than 15 cm from the distal opening, wherein the at least one distal optics assembly is positioned to visualize a FOV between the at least one distal optics assembly and the working channel distal opening; at least one proximal optics assembly positioned within the working channel between the at least one distal optics assembly and the working channel proximal opening, wherein the at least one proximal optics assembly is configured to visualize a FOV between the at least one proximal optics assembly and the distal opening of the working channel.

[0048] Example 39. A device according to example 38, wherein the at least one proximal optics assembly is positioned at a distance shorter than 10 cm from the working channel proximal opening.

[0049] Example 40. A device according to any one of examples 38 or 39, wherein the at least one proximal optics assembly is positioned proximally to the at least one distal optics assembly, within the working channel.

[0050] Example 41. A device according to any one of examples 38 to 40, wherein each of the at least one proximal optics assembly and the at least one distal optics assembly are coupled directly or indirectly to an inner surface of the elongated rigid body by at least one fastener or adhesive.

[0051] Example 42. A laryngoscope device, comprising: an elongated rigid body having a distal end shaped and sized to penetrate into a throat of a subject, and a proximal end shaped and sized to be positioned outside the throat, wherein a wall of the elongated rigid body defines and surrounds a working channel having at least one proximal opening at the proximal end, and at least one distal opening, wherein the at least one proximal opening is shaped and sized to receive a tissue manipulating tool into the working channel; at least one proximal optics assembly positioned within the working channel coupled to the wall and at a distance shorter than 10 cm from the proximal opening, wherein the at least one proximal optics assembly is configured to visualize a FOV between the at least one proximal optics assembly and the distal opening of the working channel.

[0052] Example 43. A system for visualizing tissue within a throat, comprising: a laryngoscope device comprising: an elongated rigid body having a distal end, and a proximal, wherein a wall of the elongated rigid body defines and surrounds a working channel having a proximal opening and a distal opening; at least one visualization aperture in the wall of the elongated rigid body located between the proximal opening and the distal opening of the working channel at a distance shorter than 15 cm from the distal opening, the at least one visualization aperture faces a lumen of the working channel; at least one distal optics assembly comprising at least one optic sensor, wherein the at least one distal optics assembly is positioned at least partly within the at least one visualization aperture, and wherein the at least one optic sensor has a FOV between the at least one optic sensor and the working channel distal opening ; a control unit comprising a user interface and a control circuitry functionally coupled to the user interface and to the at least one optics assembly; wherein the control circuitry is configured to receive signals from the at least one optics assembly, and to signal the user interface to generate and deliver a visual indication based on the signals received from the at least one distal optics assembly.

[0053] Example 44. A system according to example 43, wherein the laryngoscope device comprises at least one proximal optics assembly functionally coupled to the control circuitry and positioned within the working channel between the at least one distal optics assembly and the working channel proximal opening.

[0054] Example 45. A system according to example 44, wherein the at least one proximal optics assembly comprises at least one optic sensor positioned to have a FOV between the at least one proximal optics assembly and the working channel distal opening, wherein the control unit is configured to receive signals from the at least one proximal optics assembly, and to signal the user interface to generate and deliver a visual indication based on the signals received from the at least one proximal optics assembly.

[0055] Example 46. A method for visualizing tissue within a throat, comprising: introducing a laryngoscope having an elongated rigid body with at least one inner working channel, into a throat of a subject positioning following or during the introducing a distal opening of the inner working channel within the throat, and a proximal opening of the inner working channel outside the throat; visualizing a first field of view (FOV) within the inner working channel by at least one distal optics assembly comprising an optic sensor located within the inner working channel between the inner working channel distal opening and the proximal opening of the inner working channel, and wherein the visualizing comprises visualizing tissue of the throat located within the FOV inserted at least partly via the inner working channel distal opening into the inner working channel.

[0056] Example 47. A method according to example 46, wherein the visualizing comprising visualizing a second FOV within the inner working channel by at least one proximal optical assembly located within the inner working channel at a distance shorter than 10 cm from the inner working channel proximal opening, wherein the at least one distal optics assembly is positioned distally to the proximal optics assembly within the inner working channel, and wherein the second FOV is between the at least one proximal optics assembly and the inner working channel distal opening.

[0057] Example 48. A method according to example 47, comprising: presenting a two dimensional or a three dimensional image of the first FOV and / or the second FOV to a user of the laryngoscope based on signals received from the at least one distal optics assembly and / or signal received from the at least one proximal optics assembly.

[0058] Example 49. A method according to example 47 comprising, manipulating during the presenting the tissue of the throat by introducing a tool into the inner working channel via the inner working channel proximal opening.

[0059] Example 50. A method according to example 49, wherein the manipulating comprises at least one of, removing polyps from vocal cords, removal of benign lesions, and removal of malignant lesions.

[0060] Example 51. A method for visualizing tissue within throat, comprising: providing a laryngoscope comprising at least one inner working channel having a distal opening configured to be positioned within a throat of a subject and shaped and sized for introduction of tissue into the at least one inner working channel and a proximal opening configured to be positioned outside the throat, and at least one stationary optical sensor positioned to acquire a field of view (FOV) of at least part of the working channel and of the distal opening; introducing the laryngoscope working channel distal opening into a subject throat; positioning tissue of the throat within the working channel and the FOV; manipulating the tissue using at least one tool introduced through the proximal opening into the at least one inner working channel; visualizing the tissue during the positioning and / or the manipulating by the at least one stationary optical sensor.

[0061] Example 52. A method according to example 51, wherein the visualizing comprises visualizing the tissue during a time period of at least 5 minutes during the positioning and / or the manipulating.

[0062] Example 53. A method according to any one of examples 51 or 52, wherein the visualizing comprises visualizing the tissue by the at least one stationary optical sensor from a distance shorter than 15 cm between the tissue and the at least one stationary optical sensor.

[0063] Below are some additional examples of embodiments of the invention. Some examples of the invention are described herein (an embodiment may include features from more than one example and / or fewer than all features of an example):

[0064] Example 1. A laryngoscope device, comprising: an elongated body having a long axis, a distal section shaped and sized to be positioned within a throat of a subject, and a proximal section shaped and sized to be positioned outside the throat, wherein a wall of the elongated body defines and surrounds a working channel having at least one proximal opening at the proximal section, and at least one distal opening at the distal section; at least one optics channel positioned within the working channel, wherein the optics channel has at least one distal visualization aperture facing the at least one distal opening of the working channel, and at least one proximal opening; at least one distal optics assembly, comprising at least one distal camera, positioned within the at least one optics channel and proximally to the at least one distal opening of the working channel, to have a first field of view (FOV) between the at least one distal visualization aperture and the working channel distal opening, wherein the at least one camera is configured to acquire an image of the first field of view.

[0065] Example 2. A device according to example 1, wherein a length of the at least one optics channel is shorter than a length of the working channel.

[0066] Example 3. A device according to any one of examples 1 or 2, wherein the at least one distal visualization aperture of the at least one optics channel is located at a distance between 0.1 cm and 15 cm from the distal opening of the working channel.

[0067] Example 4. A device according to any one of examples 1 or 2, wherein the proximal opening of the at least one optics channel is located within the working channel and positioned at a distance shorter than 15 cm from the proximal opening of the working channel.

[0068] Example 5. A device according to any one of the previous examples, wherein the at least one optics channel is coupled to the elongated body or is integrated with the elongated body wall.

[0069] Example 6. A device according to any one of the previous examples, comprising at least one illumination source, wherein the at least one optics channel comprises a plurality of channels, wherein the plurality of channels comprise at least one camera channel shaped and sized to receive the at least one camera, and at least one illumination channel shaped and sized to receive the at least one illumination source.

[0070] Example 7. A device according to example 6, wherein the at least one illumination source is positioned in a distal opening of the at least one illumination channel to emit and direct light to the first FOV.

[0071] Example 8. A device according to example 7, wherein a distal opening of the at least one camera channel has the same axial position within the working channel as the distal opening of the at least one illumination channel. Example 9. A device according to any one of examples 7 or 8, comprising at least one illumination source fastener configured to fixedly fasten the at least one illumination source to the at least one illumination channel and / or to the distal opening of the at least one illumination channel.

[0072] Example 10. A device according to any one of examples 6 to 9, comprises at least one camera fastener configured to fixedly fasten the at least one camera to the at least one camera channel and / or to the at least one distal visualization aperture.

[0073] Example 11. A device according to any one of examples 6 to 9, wherein the at least one camera channel and the at least one illumination channel contact each other along at least 50% of their length.

[0074] Example 12. A device according to any one of examples 6 to 11, wherein the at least one illumination channel comprises at least two illumination channels, each is shaped and sized to receive a separate illumination source.

[0075] Example 13. A device according to example 12, wherein each of the at least two illumination channels is located at an opposite side of the at least one camera channel.

[0076] Example 14. A device according to any one of examples 6 to 13, wherein the at least one illumination source comprises at least one optic fiber.

[0077] Example 15. A device according to any one of the previous examples, comprising at least one proximal optics assembly positioned within the working channel at a distance shorter than 10 cm from the working channel proximal opening, wherein the at least one proximal optics assembly comprises at least one proximal camera positioned to have a second FOV between the at least one proximal optics assembly and the working channel distal opening, and is configured to acquire an image of the second FOV.

[0078] Example 16. A device according to example 15, wherein the at least one proximal optics assembly is positioned between the proximal opening of the working channel and the proximal opening of the distal optics channel.

[0079] Example 17. A device according to any one of examples 15 or 16, comprising at least one proximal fastener configured to fasten the at least one proximal optics assembly to the elongated body.

[0080] Example 18. A device according to example 17, wherein the at least one proximal fastener is integrated with the elongated body.

[0081] Example 19. A device according to any one of examples 15 or 16, comprising a proximal optics assembly holder configured to be coupled to the at least one proximal optics assembly; wherein the elongated body comprises an elongated guide extending from the elongated body through the working channel proximal opening, wherein the proximal optics assembly holder is shaped to be mechanically coupled to the elongated guide.

[0082] Example 20. A device according to example 19, wherein the elongated guide is integrated with the elongated body.

[0083] Example 21. A device according to any one of examples 15 to 20, wherein the at least one proximal camera is located proximally to the at least one distal camera, within the working channel.

[0084] Example 22. A device according to any one of examples 15 to 21, wherein the at least one proximal camera and the at least one distal camera, are located at opposite angular locations within the working channel.

[0085] Example 23. A device according to any one of the previous examples comprising an elongated rigid handle in contact with an outer surface of the elongated body at a contact location between the distal opening and the proximal opening of the working channel, wherein the elongated rigid handle is shaped and sized to be held within a palm of a subject hand.

[0086] Example 24. A device according to example 23, wherein the elongated rigid handle is oriented in an angle of between 45 degrees and 90 degrees relative to a portion of the elongated body between the contact location and the distal section of the elongated body.

[0087] Example 25. A device according to any one of examples 23 or 24, comprising one or more rigid reinforcement portions interconnecting the elongated rigid handle and the elongated body, wherein the one or more rigid reinforcement portions are configured to reinforce the contact point to resist movement of the elongated rigid handle relative to the elongated body.

[0088] Example 26. A device according to any one of examples 23 or 24, wherein the elongated body is integrated with the handle.

[0089] Example 27. A device according to example 26, wherein the elongated body and the handle are formed from at least one polymer material.

[0090] Example 28. A device according to example 27, wherein the at least one polymer material comprises at least one of, Polyether ether ketone (PEEK), Polycarbonate (PC), Polyamide, Polyethylene Terephthalate (PET) and / or, Polyethylene Terephthalate Glycol-Modified (PETG).

[0091] Example 29. A device according to any one of examples 26 to 28, wheren the elongated body and the handle are formed as a single unit in a three dimensional (3D) printing process, or in an injection molding process. Example 30. A device according to any one of the previous examples, wherein the working channel between the distal opening and the proximal opening is straight.

[0092] Example 31. A device according to any one of the previous examples, wherein a minimal width of the working channel is at least 12 mm.

[0093] Example 32. A laryngoscope device, comprising: an elongated rigid body having a long axis, a distal section shaped and sized to be positioned within a throat of a subject, and a proximal section shaped and sized to be positioned outside the throat, wherein a wall of the elongated body defines and surrounds a working channel having at least one proximal opening at the proximal second, and at least one distal opening at the distal section; at least one optics channel positioned within the working channel and integrated with the elongated rigid body; an elongated rigid handle in contact with an outer surface of the elongated body, wherein the elongated rigid handle is shaped and sized to be held within a palm of a subject hand; wherein the elongated rigid body, the at least one optics channel and the elongated rigid handle are manufactured as a single unit from at least one polymer material.

[0094] Example 33. A device according to example 32, wherein the at least one polymer material comprises at least one of, Polyether ether ketone (PEEK), Polycarbonate (PC), Polyamide, Polyethylene Terephthalate (PET) and / or , Polyethylene Terephthalate Glycol-Modified (PETG).

[0095] Example 34. A device according to any one of examples 32 or 33, wherein the elongated rigid body, the at least one optics channel and the elongated rigid handle are manufactured as a single unit in a three dimensional (3D) printing process or in an injection molding process.

[0096] Example 35. A device according to any one of examples 32 to 34, wherein a minimal length of the working channel is at least 50 mm.

[0097] Example 36. A device according to any one of examples 32 to 35, wherein a minimal width of the working channel is at least 12 mm.

[0098] Example 37. A laryngoscope device, comprising: an elongated rigid body having a distal end shaped and sized to penetrate into a throat of a subject, and a proximal end shaped and sized to be positioned outside the throat, wherein a wall of the elongated rigid body defines and surrounds a working channel having at least one proximal opening at the proximal end, and at least one distal opening; at least one distal optics assembly comprising at least one distal camera, positioned within the working channel at a distance between 0.1 cm and 15 cm from the distal opening, wherein the at least one distal optics assembly is positioned to visualize a FOV between the at least one distal optics assembly and the working channel distal opening; at least one proximal optics assembly comprising at least one proximal camera, positioned within the working channel between the at least one distal optics assembly and the working channel proximal opening, wherein the at least one proximal optics assembly is configured to visualize a FOV between the at least one proximal optics assembly and the distal opening of the working channel.

[0099] Example 38. A device according to example 37, wherein the at least one proximal optics assembly is positioned at a distance shorter than 10 cm from the working channel proximal opening.

[0100] Example 39. A device according to any one of examples 37 or 38, wherein the at least one proximal optics assembly is positioned proximally to the at least one distal optics assembly, within the working channel.

[0101] Example 40. A device according to any one of examples 37 to 39, wherein each of the at least one proximal optics assembly and the at least one distal optics assembly are coupled directly or indirectly to an inner surface of the elongated rigid body by at least one fastener or adhesive.

[0102] Example 41. A device according to any one of examples 37 to 40, wherein a minimal length of the working channel is at least 50 mm, and wherein a minimal width of the working channel is at least 12 mm.

[0103] Example 42. A laryngoscope device, comprising: an elongated rigid body having a distal end shaped and sized to penetrate into a throat of a subject, and a proximal end shaped and sized to be positioned outside the throat, wherein a wall of the elongated rigid body defines and surrounds a working channel having at least one proximal opening at the proximal end, and at least one distal opening, wherein the at least one proximal opening is shaped and sized to receive a tissue manipulating tool into the working channel; at least one proximal optics assembly positioned within the working channel coupled to the wall and at a distance shorter than 10 cm from the working channel proximal opening, wherein the at least one proximal optics assembly is configured to visualize a FOV between the at least one proximal optics assembly and the distal opening of the working channel.

[0104] Example 43. A device according to example 42, wherein a minimal length of the working channel is at least 50 mm.

[0105] Example 44. A device according to any one of examples 42 or 43, wherein a minimal width of the working channel is at least 12 mm. Example 45. A method for visualizing tissue within a throat, comprising: introducing a laryngoscope having an elongated rigid body with at least one inner working channel, into a throat of a subject positioning following or during the introducing a distal opening of the inner working channel within the throat, and a proximal opening of the inner working channel outside the throat; visualizing a first field of view (FOV) within the inner working channel by at least one distal optics assembly comprising a distal camera positioned within the inner working channel at a distance of between 0.1 cm and 10 cm from the distal opening of the inner working channel, and a second FOV within the inner working channel by at least one proximal optics assembly comprising a proximal camera positioned between the proximal opening of the inner working channel and the distal camera.

[0106] Example 46. A method according to example 45, comprising: displaying during aid visualizing at least one image of the first FOV and of the second FOV based on signal received from the distal camera and the proximal camera.

[0107] Example 47. A method according to example 46, wherein the at least one image comprises a two dimensional image (2D) image or a three dimensional (3D) image.

[0108] Example 48. A method according to any one of examples 46 or 47, wherein the at least one image comprises at least one first image of the first FOV and at least one second image of the second FOV.

[0109] Example 49. A method according to any one of examples 46 to 48 comprising, manipulating during the displaying tissue of the throat using a tool introduced into the inner working channel via the inner working channel proximal opening.

[0110] Example 50. A method according to example 49, wherein the manipulating comprises at least one of, removing polyps from vocal cords, removal of benign lesions, and removal of malignant lesions.

[0111] Unless otherwise defined, all technical and / or scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which the invention pertains. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of embodiments of the invention, exemplary methods and / or materials are described below. In case of conflict, the patent specification, including definitions, will control. In addition, the materials, methods, and examples are illustrative only and are not intended to be necessarily limiting. BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF DRAWINGS

[0112] Some embodiments of the invention are herein described, by way of example only, with reference to the accompanying drawings. With specific reference now to the drawings in detail, it is stressed that the particulars shown are by way of example and for purposes of illustrative discussion of embodiments of the invention. In this regard, the description taken with the drawings makes apparent to those skilled in the art how embodiments of the invention may be practiced.

[0113] In the drawings:

[0114] FIG. 1A is a flow chart of a general process for visualization a working channel lumen of a laryngoscope via a side aperture of the working channel, according to some exemplary embodiments of the invention;

[0115] FIG. IB is a detailed process for visualizing and optionally manipulating tissue within a laryngoscope working channel during a therapeutic procedure, according to some exemplary embodiments of the invention;

[0116] FIGs. 2A and 2B are block diagrams of a laryngoscope, according to some exemplary embodiments of the invention;

[0117] FIGs. 2C-2E are cross sections views through a laryngoscope body showing position of one or more apertures in a wall of a working channel, according to some exemplary embodiments of the invention;

[0118] FIG. 3 is a schematic illustration of a system for visualizing a field of view within a laryngoscope, according to some exemplary embodiments of the invention;

[0119] FIGs. 4A-4C are schematic illustrations of a laryngoscope with at least one integrated optic sensor, according to some exemplary embodiments of the invention;

[0120] FIG. 5 is a flow chart of a process for coupling of at least one optics assembly to a laryngoscope, according to some exemplary embodiments of the invention;

[0121] FIGs. 6A-6B are schematic illustrations of at least two optics assemblies, each is positioned within a different visualization channel of a laryngoscope, according to some exemplary embodiments of the invention;

[0122] FIG. 7A is a schematic illustration of a laryngoscope having two external visualization channels, according to some exemplary embodiments of the invention;

[0123] FIGs. 7B and 7C are cross-sections views along line AA of the laryngoscope shown in fig. 7A, without an optics assembly (fig. 7B) and with an optics assembly (fig. 7C), according to some exemplary embodiments of the invention; FIGs. 7D and 7E are cross-sections views along line BB of the laryngoscope shown in fig. 7A, without an optics assembly (fig. 7D) and with an optics assembly (fig. 7E), according to some exemplary embodiments of the invention;

[0124] FIGs. 7F and 7G are schematic illustrations of a laryngoscope having optics assemblies within two external visualization channels, according to some exemplary embodiments of the invention;

[0125] FIG. 8 is a schematic illustration of an optics assembly configured to be assembled to a laryngoscope, according to some exemplary embodiments of the invention;

[0126] FIGs. 9A-9D are schematic illustrations of a laryngoscope, for example a surgical or an operative laryngoscope having optical assemblies, optionally mechanically coupled to the laryngoscope, according to some exemplary embodiments of the invention;

[0127] FIGs, 10A-10B are cross-section views of a laryngoscope along plane A-A dividing the laryngoscope shown in figs. 9A-9D into two halves, according to some exemplary embodiments of the invention;

[0128] FIG. 11A is a cross-section view along plane A-A of the laryngoscope shown in figs. 9A- 9D having a tissue and a tool inside the working channel during a medical procedure, for example surgery, according to some exemplary embodiments of the invention;

[0129] FIG. 1 IB is a rear view of the laryngoscope shown in fig. 9A-9D, according to some exemplary embodiments of the invention;

[0130] FIGs. 12A-12D are schematic illustrations showing a laryngoscope having at least one single distal optics assembly, and at least one proximal optics assembly, according to some exemplary embodiments of the invention;

[0131] FIG. 13 includes images arranged in panels A-D showing a laryngoscope having a rear optics assembly and a single central visualization channel with at least one distal optics assembly in a working channel of the laryngoscope, and in panels El and E2 showing images acquired using the at least one distal optics assembly, according to some exemplary embodiments of the invention;

[0132] FIG. 14 includes images arranged in panels A and B, showing a laryngoscope having two spaced apart visualization channels each with at least one distal optics assembly, and in panels C and D showing images acquired by each of the distal optics assemblies, and in panel E showing an image of the working channel lumen acquired by at least one proximal optics assembly positioned within the working channel, according to some exemplary embodiments of the invention; FIG. 15 is a flow chart of a process for visualizing tissue inside a throat using a laryngoscope with at least one stationary optic assembly, and optionally determining a state of the visualized tissue using at least one model, for example a machine learning model, according to some exemplary embodiments of the invention;

[0133] FIGs. 16A and 16B are block diagrams of a laryngoscope optionally having a reinforced body, according to some exemplary embodiments of the invention;

[0134] FIGs. 16C-16H are schematic illustrations of a laryngoscope, optionally having a reinforced body, according to some exemplary embodiments of the invention; and

[0135] FIGs. 17A and 17B are schematic illustrations showing assembly of at least one camera and at least one illumination source to a laryngoscope, according to some exemplary embodiments of the invention.

[0136] DESCRIPTION OF SPECIFIC EMBODIMENTS OF THE INVENTION

[0137] The present invention, in some embodiments thereof, relates to a working channel device for visualizing objects within the working channel and / or outside the working channel, and more particularly, but not exclusively, to a laryngoscope for visualizing tissue of the throat.

[0138] A broad aspect of some embodiments of the invention relates to a working channel device, for example a laryngoscope, defining a channel and an optics assembly comprising at least one optic sensor associated with a body of the working channel device. In some embodiments, the optics assembly is positioned between at least one proximal opening, for example an opening located at a distance from a target tissue, and at least one distal opening of the channel, for example an opening located close to a target tissue. In some embodiments, the optics assembly is associated with the body of the working device in a way that does not interfere with passage through the channel and / or with entry through the at least one proximal opening into the channel. In some embodiments, the optics assembly is positioned and / or oriented to have a field of view (FOV) within the channel and / or a FOV distally to the distal opening of the channel.

[0139] According to some embodiments, the working channel device is shaped and sized to be introduced into a body cavity through an anatomic opening or a surgical opening of the body, for example, the working channel device is introducible into the vagina or through the anus into the digestive tract.

[0140] An aspect of some embodiments relates to visualizing a lumen of a working channel of a laryngoscope using or via at least one side opening, for example, an aperture in the laryngoscope body, between the distal end and a proximal end of the laryngoscope. In some embodiments, the aperture is located at an end of a channel in the laryngoscope body. In some embodiments, the aperture is an aperture in the working channel wall. In some embodiments, the lumen of the working channel is visualized via at least two apertures in the working channel wall, for example in order to generate a three dimensional (3D) image of a field of view (FOV) within the working channel. In some embodiments, the laryngoscope comprises at least one optics assembly comprises at least one optic sensor, for example a camera, associate with the at least one aperture, for example passing through the aperture, or positioned at least partly within the aperture. Optionally, the FOV is visualized by the at least one optic sensor via the aperture.

[0141] According to some embodiments, the at least one optics assembly extends into the working channel through the side opening. In some embodiments, the at least one optics assembly extends to a distance shorter than 20 cm, for example shorter than 15 cm, shorter than 10 cm, shorter than 5 cm, shorter than 2 cm or any intermediate, smaller or larger value, from the side opening into the working channel lumen.

[0142] According to some embodiments, the at least one optics assembly is positioned within a channel, for example a passage, in the laryngoscope body, terminating with the at least one side opening. Optionally, electrical wiring of the optics assembly pass within the channel. In some embodiments, the channel has an opening at the proximal end of the laryngoscope. In some embodiments, the channel is positioned outside the working channel of the laryngoscope. Alternatively, the channel is at least partly positioned within the working channel of the laryngoscope. In some embodiments, the channel is tapered, having a distal end that is narrow relative to the proximal end of the channel.

[0143] According to some embodiments, the at least one optics assembly is integrated with the laryngoscope body, for example is fixed and / or assembled to the laryngoscope body in a factory. Alternatively, the at least one optics assembly and / or the laryngoscope comprise at least one fastener, for coupling the at least one optics assembly to the laryngoscope.

[0144] In some embodiments, the at least one side opening and / or the channel of the laryngoscope is shaped and sized to receive the at least one optics assembly. In some embodiments, the at least side opening has a maximal width in a range between 0.5 mm - 5 mm, for example 0.5 mm - 2 mm, 1 mm - 3 mm, 1.5 mm - 4 mm or any intermediate, smaller or larger range of values.

[0145] According to some embodiments, the optics assembly of the laryngoscope is used for visualizing tissue within the FOV. In some embodiments, the optics assembly is used to generate a 3D image of the tissue, for example using at least two spaced-apart optic sensors of the optics assembly. Alternatively, the optics assembly is used for narrow band imaging of the tissue. In some embodiments, a 2D image of the tissue, a 3D image of the tissue and / or narrow band imaging of the tissue within the FOV is generated by a control unit functionally coupled to the laryngoscope configured to receive signals from at least one optic sensor of the optics assembly.

[0146] A potential advantage of visualizing a FOV within a working channel of a laryngoscope via a side opening in the working channel may be to allow visualization of the FOV without blocking or interfering with a passage of tools through the working channel.

[0147] Additional potential advantages of visualizing a FOV within a working channel of a laryngoscope via a side opening in the working channel may be to allow insertion of tools into the working channel, or passage of tools within the working channel without interfering with visualization of a FOV within the working channel, and a closer and more comfortable access of a user of the laryngoscope to the proximal opening of the working channel.

[0148] An aspect of some embodiments relates to a laryngoscope having an elongated body and an elongated working channel and a single visualization channel within the working channel with at least one optics assembly, within the visualization channel configured to acquire an image of a distal opening of the working channel. In some embodiments, the at least one optics assembly is a distal optics assembly, located close to a distal opening of the working channel. In some embodiments, the at least one optics assembly is positioned within the visualization channel at a distance between 0.5 cm and 20 cm from the working channel distal opening, for example at a distance between 1 cm and 10 cm, at a distance between 1 cm and 5 cm, or any intermediate, smaller or larger distance from the working channel distal opening. In some embodiments, the at least one optics assembly, for example at least one distal optics assembly is positioned at a distance shorter than 20 cm from the distal opening of the working channel, for example at a distance shorter than 15 cm, shorter than 10 cm, shorter than 5 cm, shorter than 2 cm, shorter than 1 cm, or any intermediate, smaller or larger distance from the working channel distal opening.

[0149] According to some embodiments, a distal visualization aperture of the visualization channel facing a distal opening of the working channel is located at a distance shorter than 20 cm, for example shorter than 15 cm, shorter than 10, shorter than 5 cm, or any intermediate, smaller or larger distance from the working channel distal opening.

[0150] According to some embodiments, the at least one optics assembly, comprising at least one of, a camera, an optic fiber camera, and / or an optic sensor, is configured to acquire a two dimensional (2D) image of the FOV. Alternatively, for example in case the at least one optics assembly is movable, at least the optics assembly is configured to acquire a three dimensional (3D) image of the FOV.

[0151] According to some embodiments, the laryngoscope comprises at least one proximal optics assembly positioned within the working channel, and at a distance shorter than 15 cm, for example shorter than 10 cm, shorter than 5 cm, or any intermediate, smaller or larger value, from a proximal opening of the working channel. In some embodiments, the at least one proximal assembly is configured to acquire an image of the working channel, between the proximal optics assembly and the distal opening of the working channel.

[0152] According to some embodiments, the laryngoscope comprises an elongated handle coupled to the laryngoscope elongated body, between a distal end and a proximal end of the elongated body. In some embodiments, the at least one distal optics assembly and / or the at least one proximal optics assembly, are positioned within the working channel on a plane of the laryngoscope optionally passing through a long axis of the elongated handle. In some embodiments, the midline of the laryngoscope is on, or defines a virtual plane passing through the laryngoscope elongated body and the handle, optionally dividing the laryngoscope into two symmetrical halves. Alternatively or additionally, the at least one distal optics assembly and / or the at least one proximal optics assembly are aligned relative to each other along a long axis of the laryngoscope elongated body. Alternatively or additionally, the at least one distal optics assembly and / or the at least one proximal optics assembly are axially distributed on a long axis of the laryngoscope elongated body.

[0153] An aspect of some embodiments relates to visualizing a field of view (FOV) within a working channel of a laryngoscope between a proximal opening of the laryngoscope and a distal opening of the working channel. In some embodiments, the FOV is between the distal opening and a location within the working channel that is at a distance shorter than 15 cm, for example shorter than 10 cm, shorter than 3 cm, shorter than 1 cm, or any intermediate, smaller or larger value from the proximal opening. In some embodiments, the FOV is visualized by at least one optic assembly, for example a camera positioned within the working channel and coupled to the laryngoscope body.

[0154] According to some embodiments, the at least one optic assembly is positioned at a distance shorter than 5 cm, for example shorter than 3 cm, shorter than 1 cm, or any intermediate, smaller or larger value, from a virtual midline of the laryngoscope body crossing the working channel between the distal opening and the proximal opening. In some embodiments, the at least one optic assembly is positioned at the virtual midline. According to some embodiments, the at least one proximal optic assembly is fixed, for example mechanically coupled within the working channel of the laryngoscope. In some embodiments, the at least one proximal optic assembly is mechanically coupled to the wall of the laryngoscope body surrounding the working channel. In some embodiments, the at least one proximal optic assembly blocks less than 10% of an area of a cross section made through a working channel inner lumen at the location of the at least one proximal optic assembly, for example blocks less than 5%, less than 1%, less than 0.5% or any intermediate, smaller or larger percentage of the cross section area.

[0155] A potential advantage of visualizing a FOV between the distal opening and closer as possible to the proximal opening may be to visualize the penetration of at least one tool, for example a tissue manipulating tool, through the proximal opening into the working channel and / or the movement of the tool within the working channel. An additional potential advantage may be to make sure the tool is extracted out from the patient body and / or from the working channel of the laryngoscope when a tissue manipulation procedure is completed.

[0156] According to some exemplary embodiments, the laryngoscope, for example a visualization or a surgical laryngoscope, is used during proctology procedures by introducing the laryngoscope at least partly into a rectum of a subject to visualize a field of view within the rectum. Alternatively, the laryngoscope is used during a gynecological procedure, for example by introducing the laryngoscope at least partly into a vagina of a female subject to visualize a field of view within the vagina.

[0157] According to some embodiments, the laryngoscope described herein is a surgical or an operative laryngoscope, for example a Kleinsasser laryngoscope or variations thereof.

[0158] Before explaining at least one embodiment of the invention in detail, it is to be understood that the invention is not necessarily limited in its application to the details of construction and the arrangement of the components and / or methods set forth in the following description and / or illustrated in the drawings and / or the Examples. The invention is capable of other embodiments or of being practiced or carried out in various ways.

[0159] Exemplary general process for manipulating tissue in the throat

[0160] According to some exemplary embodiments, a laryngoscope is used to introduce tools, for example surgical instruments into the throat in a safe way, without damaging surrounding tissue of the throat. In some embodiments, the tools comprise tools for contacting, moving tissue and / or fixating the tissue, without changing tissue shape, structure and / or function. Alternatively or additionally, the tools comprise tools for staining of the tissue without changing tissue shape, structure and / or function. In some embodiments, the surgical tools are used to surgically manipulate tissue at a target region within the throat, for example tissue of the larynx. In some embodiments, a working channel of the laryngoscope defines a path between a distal opening of the working channel positioned within the throat and a proximal opening of the working channel located outside the body. In some embodiments, the tissue penetrates through the distal opening into the working channel, or is located outside the laryngoscope distally to the distal opening.

[0161] According to some exemplary embodiments, at least part of a laryngoscope is introduced into a subject’s throat, at block 102. In some embodiments, a distal end of the laryngoscope is introduced through the mouth of the subject into the throat. In some embodiments, the laryngoscope distal end is advanced down the throat until reaching a target region in the throat, for example the Larynx. In some embodiments, the laryngoscope's distal end is advanced down the throat while keeping the proximal end of the laryngoscope outside the body.

[0162] According to some exemplary embodiments, when reaching a target region, tissue in the target region penetrates through a distal opening of a laryngoscope working channel into the working channel lumen. Alternatively or optionally, the distal end of the laryngoscope is placed in contact with the target region, for example to allow access to the tissue at the target region through the working channel.

[0163] According to some exemplary embodiments, a FOV within the working channel is visualized from at least one side aperture in the laryngoscope, at block 104. In some embodiments, the FOV is located between the at least one side aperture and the distal opening of the laryngoscope working channel. Optionally, the FOV extends out from the working channel and distally to the distal end of the laryngoscope and the distal opening of the working channel.

[0164] According to some exemplary embodiments, the at least one aperture is located at a wall of the laryngoscope, for example a wall of the laryngoscope defining the working channel. In some embodiments, the at least one aperture is located in an inner surface of the wall, facing the working channel lumen. In some embodiments, the at least one aperture is positioned in the wall to allow a side view of the FOV.

[0165] According to some exemplary embodiments, the FOV is visualized via at least one side apertures facing the working channel, for example to optionally generate a three-dimensional image of the FOV, at block 106. In some embodiments, the at least two side apertures are located at different sides, for example at opposite sides, of the working channel. In some embodiments, an image of the FOV, for example a three dimensional (3D) image of the FOV, is generated using electrical signals received from at least two optic sensors, each is used to visualize the FOV via a different side aperture. In some embodiments, the electrical signals are transmitted to a control unit that generates and displays the 3D image on a display.

[0166] According to some exemplary embodiments, visualization is optionally modified, at block 107. In some embodiments, the visualization is modified in order to improve the visualization of the existing FOV or to acquire an image of a new FOV. In some embodiments, the visualization is modified, for example by changing a position and / or orientation of one or more of the at least two optic sensors relative to each other. Alternatively, a position and / or orientation of one or more of the at least two optic sensors is changed relative to a location of a target tissue within or outside the working channel lumen.

[0167] According to some exemplary embodiments, visualization is optionally modified, at 107 in response to an image of the tissue, for example an image received at block 104 and / or optionally generated at block 106. In some embodiments, modifying visualization comprises changing the amount of light received by at least one optic sensor of the at least two optic sensors. Alternatively or additionally, modifying the visualization comprises modifying at least one activation parameter of the at least one optic sensor of the at least two optic sensors, for example acquisition rate, resolution, wavelength. Alternatively or additionally, modifying the visualization comprises modifying the processing of the signals received from the at least one optic sensor of the at least two optic sensors.

[0168] According to some exemplary embodiments, visualization is modified using at least one adjuster associated with optics assembly comprising at least one optics sensor, for example adjusters 213 and 215 as described in fig. 2B.

[0169] According to some exemplary embodiments, visualization is modified according to tissue characteristics and / or type. For example, in some embodiments visualization is modified in order to acquire a new FOV, generate a higher resolution image of the tissue within the FOV, and / or to generate a wider angle image, optionally when the tissue is characterized as malignant tissue. Alternatively or additionally, the visualization is modified according to a type of manipulation planned at block 108, for example the visualization is modified in order to acquire visual information needed for tissue manipulation that comprises tissue removal or tissue ablation.

[0170] According to some exemplary embodiments, tissue within the FOV is manipulated, at block 108. In some embodiments, throat tissue, for example larynx tissue located within the FOV is manipulated, for example surgically manipulated, at block 108. In some embodiments, the tissue is manipulated using at least one tool, for example a surgical tool introduced from outside the body through a proximal opening of the working channel into the working channel. In some embodiments, manipulating a tissue comprises at least one of, cutting, suturing and / or removing tissue from the throat via the working channel, removing polyps from the vocal cords, removal of benign lesions, and removal of malignant lesions. In some embodiments, tissue is removed from the throat via the working channel of the laryngoscope through the proximal opening of the laryngoscope, optionally located outside the body.

[0171] Exemplary direct laryngoscopy process

[0172] According to some exemplary embodiments, a laryngoscope is used for direct laryngoscopy procedures, in which the larynx is examined and is optionally manipulated. In some embodiments, manipulation of the larynx comprises at least one of removing foreign objects, taking a biopsy for example small tissue samples, removing polyps from the vocal cords. Alternatively or additionally, the laryngoscope is used for the removal of benign lesions for example polyps cysts, and nodules. Alternatively or additionally, the laryngoscope is used for at least one of removal of malignant lesion with cold instruments or LASER instruments, injection onto the tissue of different kinds of synthetic materials or autologous fat, for augmentation and medialization of the vocal folds and injection of other medications such as steroids, botulinum toxin.

[0173] Reference is now made to fig. IB depicting a direct laryngoscopy process, according to some exemplary embodiments of the invention.

[0174] According to some exemplary embodiments, a larynx visualizing and / or manipulating device, for example a laryngoscope is provided at block 110. In some embodiments, the provided laryngoscope comprises at least one inner visualization aperture, positioned in the wall of the laryngoscope to allow visualizing a lumen of the laryngoscope working channel. In some embodiments, the at least one inner visualization apertures comprise at least two spaced-apart visualization apertures located at different sides of the working channel. In some embodiments, the at least one visualization aperture is positioned to allow visualization of the working channel lumen from the side.

[0175] According to some exemplary embodiments, a subject is anesthetized at block 112. Optionally, the subject is generally anesthetized at block 112. In some embodiments, the head of the subject is placed in a flat supine position before, during and / or after initiating anesthesia. Alternatively, the head of the subject is placed at angle of up to 30° degrees, for example up to 25° degrees, up to 20° degrees, up to 10° degrees, or any intermediate, smaller or larger angle, relative to a longitudinal axis of the body, before, during and / or after initiating anesthesia.

[0176] According to some exemplary embodiments, the laryngoscope, for example the provided laryngoscope, is introduced into the throat at block 114. In some embodiments, a distal end of the laryngoscope is introduced through the mouth of the subject into the throat. In some embodiments, the laryngoscope distal end is introduced into the throat while a proximal end of the laryngoscope is outside the body, for example outside the mouth of the subject. In some embodiments, the laryngoscope is introduced into the throat using a handle of the laryngoscope, coupled to the laryngoscope body. In some embodiments, the laryngoscope distal end is advanced down the throat towards a target region, for example a Larynx of the subject.

[0177] According to some exemplary embodiments, the throat is optionally visualized, at block 116. In some embodiments, the throat is optionally visualized during the insertion and the advancement of the laryngoscope distal end within the throat. In some embodiments, the throat is optionally visualized during the insertion of the laryngoscope via the at least one inner visualization aperture in the laryngoscope wall. In some embodiments, the throat is visualized through the distal opening of the laryngoscope via the at least one inner visualization aperture.

[0178] According to some exemplary embodiments, the larynx is visualized at block 118. In some embodiments, the distal end of the laryngoscope is placed in contact with the larynx. In some embodiments, a portion of the larynx is visualized through the working channel of the laryngoscope, via the inner visualization aperture. In some embodiments, a portion of the larynx positioned within the working channel of the laryngoscope is visualized via the inner visualization aperture. Optionally, an image, for example a three dimensional (3D) image of the throat and / or the larynx is generated and displayed to at least one viewer.

[0179] According to some exemplary embodiments, the throat and / or larynx are visualized without blocking a working channel of the laryngoscope. Alternatively, the throat and / or larynx are visualized while blocking up to 5%, for example up to 1 %, up to 0.5%, up to 0.1 % or any intermediate, smaller or larger value percentage value of the working channel lumen. In some embodiments, the throat and / or larynx are visualized via two or more spaced-apart visualization apertures in the laryngoscope body. Optionally, the two or more spaced-apart visualization apertures face the working channel lumen, and are optionally located at different locations around the working channel lumen, for example at opposite locations.

[0180] According to some exemplary embodiments, the larynx, for example a portion of the larynx positioned within the laryngoscope working channel, is optionally manipulated, at block 120. In some embodiments, the larynx is manipulated while visualizing the throat and / or the larynx, for example as described at block 118. In some embodiments, the tissue of the larynx optionally positioned within the working channel is manipulated using at least one surgical tool introduced into the laryngoscope working channel through the proximal opening of the working channel.

[0181] According to some exemplary embodiments, manipulation of the larynx comprises performing at least one cut in the larynx tissue, for example larynx tissue positioned within the working channel of the laryngoscope, using at least one blade introduced through the working channel. Alternatively, or additionally, the at least one cut in the larynx tissue is performed by at least one blade coupled to the laryngoscope, for example coupled to the laryngoscope distal end. Alternatively or additionally, manipulation of the larynx comprises removing of tissue, for example a biopsy sample, from the larynx.

[0182] According to some exemplary embodiments, the laryngoscope is removed from the throat, at block 122. In some embodiments, the laryngoscope distal end is retracted and removed from the throat, after visualization at block 118 and / or manipulation of the larynx at block 120 is completed.

[0183] Exemplary Laryngoscope

[0184] According to some exemplary embodiments, a laryngoscope is an elongated tube that is shaped and sized to be at least partly introducible into a throat of a subject through the mouth to allow, for example, examination and / or manipulation of tissue via the throat, optionally throat tissue, for example larynx tissue. Reference is now made to fig. 2A, depicting a laryngoscope, according to some exemplary embodiments of the invention.

[0185] According to some exemplary embodiments, a laryngoscope 202 comprises an elongated body a having a longitudinal axis 206, a distal end 208 and a proximal end 210. In some embodiments, the distal end of 208 of the laryngoscope body is shaped and sized to be introduced through a mouth of a subject into a throat of the subject. In some embodiments, an outer width 212, for example outer diameter, of the laryngoscope distal end 208 is in a range between 1 cm - 15 cm, for example 1-5 cm, 5-10 cm, 3-7 cm, 5-10 cm or any intermediate, smaller or larger range of values. In some embodiments, the elongated body 204 is tapered, having a proximal end 210, which is wider than the distal end 208.

[0186] According to some exemplary embodiments, the elongated body 204 is tubular, having at least one channel, for example a working channel 214 passing through the body 204 between the proximal end 210 and the distal end 208. In some embodiments, a wall 216 of the elongated body 204 defines the working channel 214. In some embodiments, the working channel 214 comprises at least one proximal opening 218 at the proximal end 210, and at least one distal opening 220 at the distal end 208.

[0187] According to some exemplary embodiments, outer surface of the body 204, for example the outer surface of the wall 216 forming the body 204 is smooth, for example to prevent damage to tissue when the laryngoscope is advanced within the throat. In some embodiments, the elongated body 204 is rigid, for example to prevent bending and / or deformation of the working channel. In some embodiments, the elongated body is formed from metal, metal alloy, polymer or plastic. In some embodiments, an overall length of the elongated body 204 is in a range between 15-40 cm, for example in a range between 15-30 cm, between 20-35 cm or any intermediate, smaller or larger range of values.

[0188] According to some exemplary embodiments, the elongated body 204 comprises at least one aperture, for example aperture 222, in the wall 216 defining the working channel 214. In some embodiments, the aperture 222 is positioned in an inner surface of the wall 216 facing the working channel 214. In some embodiments, the aperture 222 is located between the distal end 208 and the proximal end 210 of the body 204. Alternatively or additionally, the aperture 222 is located between the distal opening 220 and the proximal opening 218 of the working channel. In some embodiments, the aperture 222 is located at a distance 226 of up to 20 cm, for example up to 15 cm, up to 10 cm, up to 5 cm or any intermediate, smaller or larger value, from the distal opening 220. In some embodiments, the at least one aperture, for example aperture 222 is located at a half of the working channel 214 closer to the distal opening 220. In some embodiments, the at least one aperture comprises two or more apertures, for example apertures 222 and 224 located at the wall 216, for example in an inner surface of the wall 216 facing the working channel 214.

[0189] According to some exemplary embodiments, the visualization apertures 222 and 224, for example as shown in fig. 2A have the same axial location in the wall 216 and a different circumferential location on the circumference of the wall 216. Alternatively, the visualization apertures 222 and 224 have different axial locations and different circumferential locations on the wall 216.

[0190] According to some exemplary embodiments, the laryngoscope 202 comprises at least one handle 228, having at least one hand gripping portion. In some embodiments, the handle 228 is shaped and sized to allow holding of the laryngoscope using a single hand. In some embodiments, the at least one handle 228 is coupled to the elongated body 204. Optionally, the at least one handle is coupled to the proximal end 210 of the elongated body 204. In some embodiments, the handle 228 is rigid, optionally formed from metal, metal alloy, polymer or plastic.

[0191] According to some exemplary embodiments, the at least one handle 228, for example an elongated angle having a long axis, is coupled to the elongated body via a hinge 230. In some embodiments, the hinge 230 allows the handle 228 to move with respect to the elongated body 204. In some embodiments, the hinge 230 is configured to allow the laryngoscope 202 to move between a folded state, in which a long axis of the at least one handle 228 is substantially parallel to the longitudinal axis 206 of the elongated body 204, and an unfolded state, in which the long axis of the handle 228 is at angle between 45° degrees and 180° degrees, for example at angle between 45° degrees and 100° degrees, at angle between 70° degrees and 95° degrees or any intermediate, smaller or larger range of angles relative to the elongated body 204. In some embodiments, in an open, for example an unfolded state, the handle 228 is at an angle of about 90° degrees, relative to the elongated body 204.

[0192] According to some exemplary embodiments, the laryngoscope 202 comprises at least one lock for locking the laryngoscope 202 in a folded or an unfolded state. In some embodiments, the at least one lock is configured to lock the handle 228 in a predetermined angle relative to the elongated body 204.

[0193] Reference is now made to fig. 2B, depicting a laryngoscope with at least one optic sensor, according to some exemplary embodiments of the invention.

[0194] According to some exemplary embodiments, the laryngoscope 202 comprises at least one optics assembly. In some embodiments, the at least one optics assembly comprises at least one optic sensor, for example optic sensor 232 in at least one visualization aperture of the laryngoscope 202, for example apertures 222 and / or 224. In some embodiments, the at least one optics assembly comprises at least one of a camera and / or a lens. Optionally the optics assembly comprises an integrated light source. In some embodiments, the at least one optic sensor 232 has a field of view (FOV) 236 within the working channel 214 between a position of the aperture 232 and the distal end 208 of the body 204. Optionally, the FOV 236 extends out from the working channel 214 and through the distal opening 220, and allows, for example, visualization of objects located outside the working channel 214 and / or distally to the distal end 208.

[0195] According to some exemplary embodiments, the laryngoscope 202 comprises two or more optic sensors, for example optic sensors 232 and 234, each is located at different apertures, for example apertures 222 and 224 of the body 204. In some embodiments, the two or more optic sensors 232 and 234 have the same FOV 236, and are optionally used to generate a three dimensional (3D) image of the FOV 236. Alternatively, a FOV of each optic sensor 232 and 234 is at least partly or completely different FOV, for example to allow visualization of a wider and combined FOV based on the FOV of each optic sensor 232 and 234.

[0196] According to some exemplary embodiments, the optic sensors 232 and 234, for example as shown in fig. 2B have the same axial location in the wall 216 and a different circumferential location on the circumference of the wall 216. Alternatively, the optic sensors 232 and 234 have different axial locations and different circumferential locations on the wall 216. Optionally, at least some of the optic sensors have different axial locations in the wall 216.

[0197] According to some exemplary embodiments, the at least one optic sensor 232 extends at least partly out from the aperture 222 into the working channel 214. In some embodiments, the at least one optic sensor 232 extends to a distance smaller than 10 cm, for example smaller than 5 cm, smaller than 3 cm, smaller than 1 cm or any intermediate, smaller or larger distance, into the working channel 214. In some embodiments, the extension of the at least one optic sensor 232 into the working channel blocks less than 10%, for example less than 5%, less than 2%, less than 1%, less than 0.5%, less than 0.1% or any intermediate, smaller or larger percentage value of the working channel lumen.

[0198] According to some exemplary embodiments, the at least one optic sensor 232 is positioned at least partly within the wall 216. In some embodiments, the at least one optic sensor 232 is positioned entirely within the wall 216, for example to prevent interference to passage within the lumen of the working channel 214.

[0199] According to some exemplary embodiments, the laryngoscope 202 comprises one or more optics assembly, for example at least two optics assemblies each comprising an optic sensor, for example optics sensors 232 and 234. In some embodiments, signals from the optics assemblies, for example from the optics sensors are used to generate an image of the FOV.

[0200] According to some exemplary embodiments, during a procedure, at least one activation parameter of the optics assembly, for example at least one activation parameter of the optic sensors is modified. In some embodiments, the at least one activation parameter comprises aperture opening, lens position and / or shape, acquisition rate, resolution or any other activation parameter. Alternatively or additionally, the at least one activation parameter comprises position and / or orientation of the optics assembly, for example position and / or orientation of at least one optic sensor, relative to at least one different optic sensor of the laryngoscope 202 and / or relative to tissue located within the laryngoscope channel or outside the laryngoscope. In some embodiments, the position and / or orientation of the optics assembly comprises position and / or orientation of the optics assembly within or relative to at least one of, the apertures 222 and 224, the visualization channels 616 and 618 shown in fig. 6A, the visualization channels 625 and 627 shown in fig. 6B, and visualization channels 718 and 720 shown in fig. 7A, 7F and 7G.

[0201] According to some exemplary embodiments, the at least one activation parameter is modified using at least one adjuster associated with one or more of the optics assemblies, for example adjusters 213 and 215. In some embodiments, the at least one adjuster is a mechanical adjuster or a motorized adjuster optionally comprising at least one motor, for example an electric motor. In some embodiments, the at least one adjuster is configured to change the position and / or orientation of the optics assembly, for example the position and / or orientation of at least one optic sensor of the optics assembly.

[0202] According to some exemplary embodiments, the at least one adjuster is manually controlled, for example by a human subject using the laryngoscope, optionally via a user interface of the laryngoscope or user interface 316 of the control unit 306. Alternatively or additionally, the control unit functionally connected to the laryngoscope controls, for example automatically controls, the at least one adjuster using information stored in the memory 314.

[0203] Reference is now made to figs. 2C-2E, which are views of the elongated body from the distal opening of the working channel, according to some exemplary embodiments of the invention.

[0204] According to some exemplary embodiments, a wall 250 of an elongated body of a laryngoscope defines a working channel 252 having an inner lumen. In some embodiments, for example as shown in fig. 2C, the wall 250 comprises at least two visualization apertures, each includes a single optic sensor, for example optic sensors 254 and 256. In some embodiments, for example as shown in fig. 2C, the optic sensors are located at different locations on the circumference of the wall. Optionally, for example as shown on fig. 2D, the at least two optic sensors 254 and 256 are located at opposite sides of the working channel 252.

[0205] According to some exemplary embodiments, for example as shown in fig. 2E, the laryngoscope comprises at least one optics assembly comprising at least one optic sensor, for example optic sensors 254 and 256, at least one illumination source 258, for example at least one lamp for delivering light into the working channel 252, and / or at least one mirror. In some embodiments, the optics assembly comprises at least one optic sensor and / or at least one light director, for example a mirror and / or a lens, in one or more visualization apertures facing the working channel lumen. Alternatively, each of the at least one optic sensor and / or the at least one mirror and / or the at least one lens is positioned at different visualization apertures facing the working channel lumen.

[0206] According to some exemplary embodiments, a laryngoscope, for example the laryngoscope shown in figs. 2A and 2B, further comprises at least one proximal optical assembly 221 (also termed herein as optics assembly). In some embodiments, the optical assembly 221 which is optionally similar to the optics assembly 222 and 224, is coupled to the inner surface of the wall 216, within the working channel 214. In some embodiments, the at least one proximal optical assembly 221 is positioned closer or adjacent to the opening 218, for example at a distance shorter than 15 cm, for example shorter than 10 cm, shorter than 7 cm, shorter than 5 cm or any intermediate, smaller or larger distance from the proximal opening 218.

[0207] According to some exemplary embodiments, the at least one proximal optical assembly 221 is positioned to acquire a FOV 223 between the optics assembly 221 and the distal opening 220. In some embodiments, the at least one proximal optical assembly 221 is centrally positioned on a midline of the body 204, coupled to the wall 216, for example between the optics assemblies 224 and 224, or the sensor 232 and 234.

[0208] According to some exemplary embodiments, the inner surface of the laryngoscope body 204 is coated with a light reflecting coating, for example a light reflecting material, optionally paint, for example to enhance the illumination within th working channel.

[0209] Exemplary system

[0210] According to some exemplary embodiments, a laryngoscope comprises at least one, for example two or more, optic sensor, in at least one aperture in the laryngoscope body wall facing the laryngoscope working channel. In some embodiments, the at least one optic sensor is configured to visualize the working channel lumen, for example tissue within the working channel lumen. In some embodiments, the at least one optic sensor is configured to allow visualization of the working channel lumen and optionally tissue located distally to the laryngoscope via the working channel distal opening, during tissue manipulation. Additionally or optionally, the at least one optic sensor is configured to allow visualization of the working channel lumen and optionally tissue located distally to the laryngoscope via the working channel distal opening, during the advancement of the laryngoscope within the throat. In some embodiments, a control unit or a display coupled to the laryngoscope and / or to the at least one optic sensor displays the FOV observed by the at least one optic sensor on a display. Reference is now made to fig. 3 depicting a system for visualizing and / or manipulating tissue using a laryngoscope, according to some exemplary embodiments of the invention.

[0211] According to some exemplary embodiments, a system for visualizing and / or manipulating tissue, for example system 302 comprises a laryngoscope 304 functionally coupled to a control unit 306. In some embodiments, the laryngoscope 304 comprises at least one optic sensor, for example optic sensors 308 and 310. In some embodiments, the laryngoscope comprises at least one proximal optic sensor, which is similar to optical assembly 221 shown in figs. 2A and 2B. In some embodiments, a control circuitry 312 of the control unit 306 is functionally connected to the optic sensors 308, 310 and / or 321. Optionally, the control unit 312 is functionally connected to the optic sensors 308 and 310 using a communication circuitry of the control unit 306 that receives wireless signals, for example Wi-Fi or Bluetooth signals from the optic sensors 308, 310 and 321, or signals via wires connecting the optic sensors 308, 10 and 321 and the control unit 308. In some embodiments, the laryngoscope 304 comprises a communication circuitry 311, functionally coupled to at least one optic sensor of the laryngoscope, for example optic sensors 308 and 310. In some embodiments, the communication circuitry generated and delivers wireless signals to the control unit 306 based on signals received form the optic sensors 308 and 310.

[0212] According to some exemplary embodiments, the control circuitry 312 is configured to process the signals received from the laryngoscope, for example from the optic sensors 308, 310 and / or 321 using at least one algorithm, software program or a lookup table, stored in a memory 314 of the control unit 306. In some embodiments, the control circuitry 312 is configured to generate an image, for example a three dimensional (3D) image based on the processed signals received from the optic sensors 308 and 310. In some embodiments, the processing comprises at least one of, filtering signals received from at least one optic sensor, modifying at least one parameter of the signals in order, for example to zoom-in and / or zoom-out, and to affect at least one of focus, resolution, brightness and / or saturation of the generated image.

[0213] According to some exemplary embodiments, at least one algorithm, software program or a lookup table, stored in a memory 314 of the control unit 306 is used for processing of 2D or 3D images, and for identifying tissue types and / or tissue state within the images. For example, the at least one algorithm, software program or a lookup table is used, in some embodiments, to differentiate between a benign and a tumorigenic tissue within the FOV.

[0214] According to some exemplary embodiments, the at least one algorithm, software program or a lookup table, stored in a memory 314 of the control unit 306 is used for processing signals received form the proximal sensor 321, for generating an image of at least part of the inner lumen, also termed herein as a working channel, of the laryngoscope body. In some embodiments, this image is used for visualizing movement and / or presence of a tool 322 within the inner lumen.

[0215] According to some exemplary embodiments, the control unit 306 comprises at least one user interface, for example user interface 316. In some embodiments, the user interface 316 is configured to receive at least one input signal from a subject, for example a subject controlling the movement of the laryngoscope, a subject manipulating tissue via the laryngoscope or any other subject located at the same room with the patient. In some embodiments, the user interface is functionally connected to a display, for example display 318. In some embodiments, the user interface 316 displays the image, for example 3D image generated by the control circuitry 312.

[0216] According to some exemplary embodiments, the display 318 allows, for example, to simultaneously present a 2D or a 3D image of the working channel lumen and / or of tissue of the throat to two or more individual human subjects, for example human subject located near the patient. In some embodiments, the image is displayed to the subject 320, for example a physician, while the subject 320 holds the laryngoscope 304 and / or a tool 322, for example a surgical tool, introduced through the working channel 324 of the laryngoscope 304. In some embodiments, the subject 320 controls the movement of the tool 322 when manipulating tissue 326 within the throat 328. In some embodiments, the display allows to show the insertion of the tool 322 into the working channel of the laryngoscope and / or the movement of the tool towards the tissue 326.

[0217] According to some exemplary embodiments, the optics assembly comprises at least one actuator functionally coupled to the optics sensor, for example actuators 313 and 315. In some embodiments, the actuators are configured to control manually or automatically, for example based on signals received from the control unit 306, at least one of, a position of one or more optics assemblies, an orientation of the optics assembly or the position and / or orientation of the optics sensors in each of the optics assemblies, for example to optimize the image acquisition for the desired 3D reconstruction.

[0218] According to some exemplary embodiments, during a procedure a different FOV may be selected and acquired, by changing a position and / or orientation of the optics assemblies or the position and / or orientation of the optic sensors relative to the working channel and / or within the working channel of the laryngoscope. Exemplary Laryngoscope with integrated optic sensors

[0219] According to some exemplary embodiments, a laryngoscope comprises at least one integrated optic sensor positioned at least partly within a visualization aperture in the wall of the laryngoscope, for example an aperture facing a working channel lumen of the laryngoscope. Optionally, the laryngoscope comprises two or more optic sensors, each is associated with a different visualization aperture in the laryngoscope wall, facing the working channel lumen. In some embodiments, the optic sensor at least partly extends out from the visualization aperture into the working channel lumen. Alternatively, the optic sensor is positioned within the laryngoscope wall to visualize a FOV within the working channel through the visualization aperture. Optionally, the laryngoscope with at least one integrated optic sensor is disposable, for example to allow a single use of the laryngoscope without a need for re- sterilization prior to a second use.

[0220] Reference is now made to figs. 4A-4C, depicting a laryngoscope with at least one integrated optic sensor, according to some exemplary embodiments of the invention.

[0221] According to some exemplary embodiments, for example as shown in fig. 4A. a laryngoscope 402 comprises an elongated body 404 having a distal end 406 shaped and sized to penetrate into a throat of a human patient, and a proximal end 408 configured to be positioned outside the subject body or outside the throat. In some embodiments, the elongated body 404 is a tubular elongated body having optionally a tapered distal end 406. In some embodiments, the elongated body 404 comprises an inner working channel 410 having a proximal opening 412 at the proximal end 408 and a distal opening 414 at the distal end 406.

[0222] According to some exemplary embodiments, working channel 410 is defined by a wall 416 of the elongated body 404 surrounding the working channel 410 lumen. In some embodiments, the laryngoscope 402 comprises at least two integrated optic sensors, for example optic sensors 418 and 420. In some embodiments, each of the optic sensors 418 and 420 is positioned within a different visualization aperture facing the lumen of the working channel 410, in the wall 416.

[0223] According to some exemplary embodiments, the at least two optic sensors 418 and 420 have a shared FOV 422 within the working channel 410, for example a shared FOV between the position of the optic sensors 418 and 420 and the distal opening 414 of the working channel 410.

[0224] According to some exemplary embodiments, as shown in fig. 4A, a laryngoscope 402 comprises at least one channel, for example, two channels 424 and 426 extending from the proximal end 408 within the wall 416. In some embodiments, each channel terminates with a visualization aperture comprising an optic sensor of the at least two optic sensors 418 and 420. In some embodiments, electrical wiring electrically connected to each of the optic sensors pass within the channel, towards an opening of each channel located at the proximal end 408. In some embodiments, the electrical wiring electrically connects each of the optic sensors to the control unit 306 or directly to a display, for example display 318.

[0225] According to some exemplary embodiments, each channel is positioned within the wall 416 between an outer surface of the wall and an inner surface of the wall facing the working channel 410. In some embodiments, the at least one channel pass within the working channel 410, between the proximal end 408 and the visualization aperture. Alternatively, or additionally, at least one channel pass outside the working channel, for example between the proximal end 408 and the visualization aperture. Optionally, the channel serves as a passage for electrical wiring connected to each optic sensor, which is outside the working channel lumen to optionally prevent any contact between the electrical wiring and objects, for example tools introduced into the working channel through the proximal opening.

[0226] According to some exemplary embodiments, for example as shown in fig. 4B, electrical wiring 428 and 430 from at least two optic sensors of the laryngoscope pass within a single channel 432 in the laryngoscope wall. Optionally, electrical wiring from a first optic sensor is connected to a second optic sensor.

[0227] According to some exemplary embodiments, for example as shown in fig. 4C, electrical wiring from at least one or both optic sensors exit from the laryngoscope wall through at least one opening in the outer surface of the wall located between a distal end 406 and a proximal end 408 of the laryngoscope body.

[0228] According to some exemplary embodiments, in a laryngoscope having at least one integrated optic sensor for example at least two integrated optic sensors, the at least one optic sensor is fixed, for example mechanically coupled, to the body of the laryngoscope, between a distal end and a proximal end of the body, within an aperture in the body facing the working channel, during the manufacturing of the laryngoscope. In some embodiments, the at least one integrated optic sensor is fixed to the body using adhesive, for example glue, and / or using one or more pins or any other mechanical fixators, mechanically interconnecting the at least one optic sensor to the laryngoscope body.

[0229] According to some exemplary embodiments, in a laryngoscope having at least one integrated optic sensor the at least one optic sensor is irreversibly fixed to the body of the laryngoscope, for example is fixed to the body of the laryngoscope in a way that prevents separation without causing damage to the laryngoscope body and / or to the optic sensor.

[0230] Exemplary process for adding an optics assembly to a laryngoscope

[0231] According to some exemplary embodiments, a laryngoscope comprises at least one optic sensor that is connected to the laryngoscope body by a user of the laryngoscope. In some embodiments, the at least one optic sensor is removably assembled to the laryngoscope body, for example by a user of the laryngoscope. Alternatively, the at least one optic sensor is irreversibly assembled to the laryngoscope body, for example by the user of the laryngoscope. In some embodiments, the at least one optic sensor is part of an optics assembly which optionally includes at least one illumination source, for example a lamp or a light emitting diode (LED). Reference is now made to fig. 5, depicting a process for adding an optics assembly to a laryngoscope, according to some exemplary embodiments of the invention.

[0232] According to some exemplary embodiments, a laryngoscope with one or more visualization apertures is provided at block 502. In some embodiments, the one or more visualization apertures, for example 2, 3, 4 or any larger number of visualization apertures is located in a surface of the laryngoscope facing a working channel of the laryngoscope. In some embodiments, the one or more visualization apertures is shaped and sized to receive an optic sensor, for example a camera. Optionally, the term optic sensor comprises a lens, a mirror and / or illumination of an optic sensor. Additionally, at least one visualization apertures of two or more visualization apertures is shaped and sized to receive an illumination source, for example a lamp or a LED lamp, in a position that allows illumination of the laryngoscope working channel and / or a FOV within the working channel.

[0233] Optionally, the laryngoscope comprises one or more fasteners, for example integral fasteners, for example for fastening at least one external optic sensor attached to the laryngoscope. In some embodiments, the one or more fasteners is associated with at least one visualization aperture and / or with a passage in the laryngoscope body terminating with the at least one visualization port.

[0234] According to some exemplary embodiments, at least one optics assembly comprising at least one optic sensor is introduced into the laryngoscope, for example the provided laryngoscope, at block 504. In some embodiments, the at least one optic assembly is introduced into the visualization apertures of the laryngoscope. In some embodiments, the optic assembly comprising the at least one optic sensor and electrical wiring connected to the optic sensor is introduced via a passage in the laryngoscope body, for example a channel, terminating with at least one visualization aperture. In some embodiments, the optic assembly, optionally having a flexible and / or a bendable body terminating with the optic sensor, is advanced within the passage towards the at least one visualization aperture.

[0235] According to some exemplary embodiments, the optics assembly is positioned in a selected location in the laryngoscope, at block 506. In some embodiments, at least one optic assembly, for example at least one optic sensor is positioned at a selected location relative to the at least one visualization aperture and / or relative to the working channel of the laryngoscope. In some embodiments, the location for positioning the optic assembly is selected according to desired dimensions and / or a desired location of a FOV within the working channel.

[0236] In some embodiments, a selected location for an optics assembly is a location where the optic sensor, for example a lens of the optic sensor extends at least partly through the visualization aperture into the working channel.

[0237] Optionally, positioning the optics assembly in a selected location comprises positioning the optics assembly in a selected orientation relative to the visualization aperture and / or relative to the working channel. In some embodiments, positioning the optics assembly in a selected orientation comprises positioning the optics assembly, for example an optic sensor or a lens of an optic sensor in a specific target angle relative to the visualization aperture and / or relative to working channel of the laryngoscope.

[0238] According to some exemplary embodiments, the optics assembly is fixed in the selected location in the laryngoscope, at block 508. In some embodiments, the optics assembly is fixed to the laryngoscope body in the selected location and / or in a selected orientation, using at least one fastener of the laryngoscope. Alternatively or additionally, the optics assembly is fixed to the laryngoscope body in the selected location and / or in a selected orientation, using at least one fastener of the optics assembly. Optionally, a first fastening element of the laryngoscope interlocks with a second fastening element of the optics assembly.

[0239] According to some exemplary embodiments, the optics assembly is optionally calibrated at block 510. In some embodiments, the optics assembly, for example at least one optic sensor is calibrated, for example to reach a desired FOV within the working channel. In some embodiments, the optics assembly comprises two or more optics assemblies, for example two or more optic sensors located at different visualization apertures at different sides, for example opposite sides of the working channel. In some embodiments, each of the optic sensors of the two or more optic sensors, is calibrated in order to have a FOV that is at least partly shared between the two or more optic sensors. In some embodiments, having a shared FOV, observed from two or more point of view allows for example, to generate a 3D image of an object located within the shared FOV.

[0240] According to some exemplary embodiments, calibrating the optics assembly comprises adjusting a position and / or an orientation of a first optics assembly relative to at least one of, a visualization aperture, working channel, and object within the working channel and / or relative to a second optic assembly. Optionally, once calibration is over, the at least one optics assembly is fixed in a new location and / or in a new orientation, for example as described at block 508.

[0241] According to some exemplary embodiments, a FOV in the working channel lumen is visualized at block 512. In some embodiments, the FOV is visualized by at least one, for example two or more optic assemblies associated, for example attached or assembled to the laryngoscope body and / or located within or on the laryngoscope body.

[0242] According to some exemplary embodiments, the FOV visualization is optionally modified at block 514. In some embodiments, the FOV visualization is modified at block 514 as previous described at block 107. In some embodiments, the FOV is modified, for example, in response to information regarding tissue within the FOV, for example identification or characterization of the tissue. Alternatively or additionally, the FOV visualization is optionally modified in order to allow improved image acquisition for further analysis of the tissue.

[0243] Exemplary laryngoscope with visualization channels

[0244] According to some exemplary embodiments, a laryngoscope comprises at least one, for example to or more channels, for example visualization channels in the laryngoscope body. In some embodiments, each of the visualization channels terminates with a visualization aperture facing the working channel lumen. In some embodiments, the visualization channels are configured to receive an optics assembly, for example an endoscope, having an elongated body terminating with at least one optic sensor. In some embodiments, the optics assembly in configured to penetrate via an opening of a visualization channel located outside the body into the visualization channel, for example to position an optic sensor at least partly in the working channel, via the visualization aperture.

[0245] Reference is now made to figs. 6A and 6B, depicting a laryngoscope with at least two optics assemblies, each is positioned within a different visualization channel of the laryngoscope, according to some exemplary embodiments of the invention. According to some exemplary embodiments, a laryngoscope, for example laryngoscope 602 has an elongated body 604 having a distal end 606 and a proximal end 608. In some embodiments, the elongated body comprises an inner working channel having a distal opening 610, optionally at the distal end 610 and a proximal opening 612 at the proximal end 608 of the elongated body.

[0246] According to some exemplary embodiments, the elongated body 604 comprises at least one for example two or more visualization channels 616 and 618, each terminates with a distal visualization aperture facing a lumen of the working channel 614. In some embodiments, the visualization channels 616 and 618, for example as shown in fig. 6A, are positioned within the working channel 614, such that each of the visualization channels pass or have an opening, for example openings 620 and 622, within the proximal opening 612 of the working channel 614. A potential advantage of visualization channels passing within the working channel may be to allow a smooth flat, non-wavy outer surface of the laryngoscope body.

[0247] Alternatively, for example as shown in fig. 6B, the at least one visualization channel, for example visualization channels 625 and 627, pass outside the working channel 614. In some embodiments, each of the visualization channels has a distal visualization aperture and a proximal opening 620 located outside the proximal opening 612 of the working channel 614. A potential advantage of visualization channels that pass outside the working channel may be to leave the working channel open without causing interference to passage of tools within the working channel.

[0248] According to some exemplary embodiments, for example as shown in figs. 6A and 6B, at least one optics assembly is positioned, for example fixedly positioned within each of the visualization channels, with at least one optic sensor extending out from a visualization aperture at a distal end of each visualization channel into the working channel 614.

[0249] According to some exemplary embodiments, an optics assembly comprises an elongated, optionally flexible, body having at least one optical sensor at a distal end of the optics assembly body. Optionally, the optics assembly comprises an illumination source at the distal end of the optics assembly body. In some embodiments, the optics assembly comprises an endoscope 624, for example a flexible endoscope positioned within each visualization channel, while at least one optic sensor 626 and optionally at least one illumination source at the distal end of the endoscope extend at least partly through a visualization aperture into the working channel 614.

[0250] According to some exemplary embodiments, each laryngoscope comprises at least one fastener, for example a lock, for locking the optics assembly and / or at least one optic sensor of the optics assembly in a desired position and / or orientation within a visualization channel. In some embodiments, the at least one fastener, for example fastener 630, is associated with a visualization channel, for example with a proximal opening of the channel through which the optics assembly is introduced into the visualization channel. Alternatively, at least one fastener, for example at least one additional fastener of the laryngoscope is associated with a visualization aperture at the end of each visualization channel, for example to lock the optic sensor at a desired extension distance from the visualization aperture into the working channel, and / or in a desired orientation.

[0251] According to some exemplary embodiments, the at least one lock is configured to lock the optics assembly, for example an endoscope in a desired axial position with the visualization channel and / or in a desired orientation, for example angle, within the visualization channel. In some embodiments, the at least one lock comprises a rotating knob configured to control a movement of a pin coupled to the knob within the visualization channel. In some embodiments, movement of the pin into the visualization channel applies force of the optics assembly body, for example on the endoscope that limits axial and / or rotational movement of the endoscope within the visualization channel.

[0252] According to some exemplary embodiments, electrical wiring, for example wiring 640 and 642 connect each of the optics assemblies of a laryngoscope, for example optics assembly 624 and 644 to a control unit, for example control unit 306 shown in fig. 3.

[0253] Exemplary laryngoscope with external visualization channels

[0254] Reference is now made to figs. 7A-7G, depicting a laryngoscope with two external visualization channels, according to some exemplary embodiments of the invention.

[0255] According to some exemplary embodiments, a laryngoscope 702 comprises an elongated body 704 having a distal end, shaped and sized to penetrate into a throat of a patient, for example a human patient, and a proximal end 708 shaped and sized to be positioned outside the body of the patient, for example outside the throat of the patient. In some embodiments, the elongated body is tapered, having a distal end 706 that is narrower than the proximal end 708. In some embodiments, a maximal outer width of the distal end 706 is in a range of 3 cm - 20 cm, for example 3 cm - 10 cm, 5 cm - 12 cm, 6 cm - 15 cm or any intermediate, smaller or larger range of values. In some embodiments, a maximal outer width of the proximal end 708 is in a range of 15 cm - 35 cm, for example 15 cm - 20 cm, 17 cm - 25 cm, 20 cm - 30 cm, 18 cm - 35 cm, or any intermediate, smaller or larger range of values.

[0256] According to some exemplary embodiments, the elongated body 704 is tubular, comprising an inner working channel 710 crossing the elongated body 704 along a long axis 712 of the body 704. In some embodiments, the inner working channel comprises at least one proximal opening 714, optionally at the proximal end 708 and at least one distal opening 716, optionally at the distal end 706. In some embodiments, the laryngoscope body 704 comprises at least two visualization apertures in a wall surrounding the working channel 710. In some embodiments, each visualization aperture faces the working channel lumen. In some embodiments, the at least two visualization apertures are located on different sides, optionally on opposite sides of the working channel 710.

[0257] According to some exemplary embodiments, the proximal opening 710 and / or a cross section of the elongated body at the proximal end 708 is oval. In some embodiments, the distal opening 716 and / or a cross section of the distal end 706 is round.

[0258] According to some exemplary embodiments, the at least two visualization apertures are located between the proximal opening 714 of the working channel and the distal opening 716 of the working channel. In some embodiments, a distance between both or at least one visualization aperture from the distal opening 716 is in a range of 2 cm -30 cm, for example 5 cm - 10 cm, 5 cm - 20 cm, 7 cm - 15 cm or any intermediate, smaller or larger range of values.

[0259] According to some exemplary embodiments, the elongated body 704 comprises at least two channels, for example visualization channels on different sides of the working channel 710 and pass outside the working channel 710 along the long axis 712 of the body 704. In some embodiments, the at least two channels, for example channels 718 and 720, each having a proximal opening for example openings 722 and 724, optionally located at the proximal end 708 of the laryngoscope, or proximally to the proximal end 708. In some embodiments, each of the at least two channels 718 and 720 terminates with a visualization aperture of the at least two visualization apertures, for example visualization apertures 726 and 728 shown in fig. 7D.

[0260] According to some exemplary embodiments, for example as shown in fig. 7A the two channels 718 and 720 are tapered towards the visualization aperture at a distal end of each channel. In some embodiments, for example as shown in figs. 7C and 7E, the two channels 718 and 720 are used as passages for introducing optical assemblies 730 and 732, each in a different channel, towards the visualization apertures. In some embodiments, a channel of the two channels 718 and 720 is used as a passage for introducing at least one optic sensor of an optical assembly, for example optic sensors 734 and 736 at least partly via the visualization apertures 726 and 728 into the working channel 710.

[0261] According to some exemplary embodiments, for example when an optics assembly is added to a laryngoscope, the two channels, for example channels 718 and 720 serve as passages for advancing an optics assembly body comprising wiring towards the visualization apertures in the working channel. In some embodiments, at least one optic sensor and optionally at least one illumination source at a distal end of the optics assembly body penetrate at least partly via the visualization apertures into the working channel, to acquire, for example, a desired FOV within the working channel.

[0262] According to some exemplary embodiments, an optics assembly assembled to the laryngoscope body comprises an endoscope having an elongated body, optionally a flexible elongated body, terminating at the distal end with at least one optic sensor and optionally at least one illumination source. In some embodiments, the endoscope is introduced through a proximal opening of a visualization channel and is advanced towards a visualization aperture. In some embodiments, an optic sensor of the endoscope and optionally the at least one illumination source are positioned in the visualization aperture, facing the working channel. Alternatively, the optic sensor of the endoscope and optionally the at least one illumination source extends out from the visualization aperture into the working channel. In some embodiments, the optic sensor and optionally the at least one illumination source extends out from the visualization aperture to a distance shorter than 20 cm, for example shorter than 15 cm, shorter than 10 cm, shorter than 5 cm, shorter than 2 cm, or any intermediate, shorter or longer distance into the working channel.

[0263] According to some exemplary embodiments, for example as shown in figs. 7F and 7G, the channels, for example channel 720 is used as a passage for electrical wiring 750 between at least one optic sensor and optionally at least one illumination source positioned at least partly within a visualization aperture, and a control unit and / or a power source located outside the body. In some embodiments, the electrical wiring extends out from the laryngoscope body 704 via a proximal opening of the channel, for example opening 724 of channel 720, and opening 722 of channel 718.

[0264] Exemplary optics assembly

[0265] According to some exemplary embodiments, an optics assembly is integrated in the laryngoscope body. Alternatively, the optics assembly is configured to be assembled, for example removably assembled to a laryngoscope body, according to some exemplary embodiments of the invention.

[0266] Reference is now made to fig. 8 depicting an optics assembly, according to some exemplary embodiments of the invention.

[0267] According to some exemplary embodiments, an optics assembly, for example optics assembly 802, is configured to be assembled to a laryngoscope body. In some embodiments, the optics assembly comprises a body 804, for example an elongated body, having a distal end 806 configured to be positioned at least partly within a working channel of a laryngoscope, and a proximal end 808 optionally configured to be positioned outside the laryngoscope body. In some embodiments, the body 802 is shaped and sized to pass through a channel and / or through at least one opening in the laryngoscope body, optionally surrounding the laryngoscope working channel.

[0268] According to some exemplary embodiments, the optics assembly comprises at least one light directing element 810, for example a lens and / or a mirror, at the distal end 806, and at least one optic sensor 814. In some embodiments, the at least one at least one light directing element 810 is configured to direct light towards the at least one optic sensor. In some embodiments, the optics assembly comprises at least one light directing element adjuster, for example adjuster 816 functionally coupled to the at least one light directing element 810. In some embodiments, the adjuster 816 is configured to controllably move the at least one light directing element 810, for example to change a direction of FOV 812 acquired by the at least one light directing element 810. In some embodiments, the adjuster 816 is a manual lens adjuster. Alternatively, the adjuster 816 comprises an actuator, for example a motor.

[0269] According to some exemplary embodiments, the optics assembly 802 comprises at least one actuator, for example a motor, functionally coupled to the body. In some embodiments, the actuator is configured to tilt the distal end 806 comprising the at least one light directing element 810 relative to a long axis 820 of the optics assembly body, for example to change a direction of the FOV 812 acquired by at least one light directing element 810.

[0270] According to some exemplary embodiments, the optics assembly 802 comprises at least one fastener 822 configured to fasten, for example reversibly fasten, the body 804 to a laryngoscope body. In some embodiments, the fastener 822 comprises adhesive, or a vacuum suction cup. Exemplary laryngoscope

[0271] According to some exemplary embodiments, a laryngoscope, for example a visualization laryngoscope, comprises at least two optical assemblies, positioned within an inner lumen of the laryngoscope. In some embodiments, the laryngoscope comprises a surgical or an operative laryngoscope, for example a Kleinsasser laryngoscope or variations thereof. In some embodiments, each of the two optical assemblies is positioned at an opposite side of the inner lumen, near a distal opening of the laryngoscope inner lumen. In some embodiments, the at least two optical assemblies, for example distal optical assemblies, are used to generate an image, for example a 3D image of at least one object introduced at least partly through the distal opening of the laryngoscope to the inner lumen. In some embodiments, the at least one object comprises body tissue, introduced into the inner lumen via the distal opening during a surgical procedure or during an examination procedure.

[0272] According to some exemplary embodiments, the laryngoscope comprises at least one additional optical assembly, for example a proximal optical assembly positioned within the laryngoscope inner lumen, near a proximal opening of the inner lumen. In some embodiments, the proximal optical assembly is positioned and / or oriented to have a forward FOV which includes at least part of the inner lumen and / or the distal opening of the inner lumen. In some embodiments, the distal opening is used, for example, to visualize at least one object, for example a surgical tool, a tissue manipulating tool, a visualizing tool, introduced at least partly into the laryngoscope inner lumen via the proximal opening of the inner lumen. Optionally, the object is introduced into the inner lumen via the proximal opening during a surgical procedure and / or during an examination procedure.

[0273] Reference is now made to figs. 9A-9D, and figs. 10A-10B, depicting a laryngoscope comprises at least two distal optical assemblies and at least one proximal optical assembly within the laryngoscope inner lumen, according to some exemplary embodiments of the invention.

[0274] According to some exemplary embodiments, a laryngoscope 900 comprises an elongated body 902 having a distal end 904 and a proximal end 906. In some embodiments, the distal end 904 is a beveled end. In some embodiments, the beveled end has a distally extending end 912 and a proximal end 913. In some embodiments, the laryngoscope 900 comprises a handle 908 shaped and sized to be held by a single human hand. In some embodiments, the handle 908 is coupled to the body 902 between the distal end 904 and the proximal end 906. Optionally, the handle 908 is coupled to the proximal end , or at a distance shorter than 50%, shorter than 25%, shorter than 5% or any intermediate smaller or larger percentage of the entire length of the elongated body 902, from the proximal end 906.

[0275] According to some exemplary embodiments, the handle 908 is coupled to the elongated body 902 at an angle 914, between the handle 908 and the elongated body 902. In some embodiments, the angle 914 is smaller than 90 degrees, for example smaller than 60 degrees, smaller than 45 degrees, smaller than 30 degrees, or any intermediate, smaller or larger angle.

[0276] According to some exemplary embodiments, the laryngoscope 900 comprises at least one, for example at least two optical assemblies, for example distal optical assemblies, positioned within an inner lumen 910 of the body 902. In some embodiments, the inner lumen 910 extends between the distal end 904 and the proximal end 906. In some embodiments, the at least two optical assemblies are positioned near the beveled distal end 904, optionally near a proximal end 913 of the beveled end. In some embodiments, the at least two optical assemblies are positioned at a minimal distance which is smaller than 30 cm from the beveled distal end 904, for example at a distance smaller than 15 cm, smaller than 10 cm, smaller than 5 cm, or any intermediate, shorter or larger distance from the beveled end 904. In some embodiments, the at least two optical assemblies are positioned within the inner lumen 910 between the distal end 904 and the proximal end 906.

[0277] According to some exemplary embodiments, the at least two distal optical assemblies, for example optical assemblies 915 and 917, are located at a distance which is smaller than 30 cm from a distal opening 919 of the inner lumen 910, for example at a distance smaller than 15 cm, smaller than 10 cm, smaller than 5 cm, or any intermediate, shorter or larger distance from the distal opening 919. In some embodiments, the at least two optical assemblies, comprise at least one of a lens, illumination and / or an optic sensor. In some embodiments, the at least two distal optical assemblies are positioned and / or are configured to allow visualization of a FOV distally to the optical assemblies 915 and 917 which includes at least part of the inner lumen between the optical assemblies 915 and 917 and the distal opening 919. Optionally, the FOV of the distal optical assemblies extends distally to the distal opening 919 and / or distally to the distal end 904.

[0278] According to some exemplary embodiments, the laryngoscope comprises at least one additional optical assembly, for example a proximal optical assembly, within the inner lumen 910 near or at a proximal end 906 of the body 902. In some embodiments, the proximal optical assembly, for example optical assembly 916 is located at a distance shorter than 15 cm, for example shorter than 10 cm, shorter than 5 cm, or any intermediate, shorter or longer distance from a proximal end 906 of the body, or from a proximal opening 918 of the inner lumen. According to some exemplary embodiments, the proximal optical assembly 916 is positioned and / or configured to have a FOV between the proximal optical assembly 916 and the distal opening 919 of the inner lumen. In some embodiments, the FOV of the proximal optical assembly includes at least 50 % of the inner lumen 910 volume, for example at least 70%, at least 90%, at least 95% or any intermediate, smaller or larger percentage of the inner lumen volume. In some embodiments, the proximal opening assembly is used to visualize objects penetrating into the inner volume 910 through the proximal opening 918, optionally as closer as possible to the proximal opening 918.

[0279] According to some exemplary embodiments, the proximal optical assembly 916 is located opposite to the position of the distal optical assemblies 915 and 917, for example at an opposite surface or at an opposite side of the inner lumen 910. For example, the proximal optical assembly is located at a lower side and the distal optical assemblies are located at an upper side of the inner lumen 910. In some embodiments, sides as described herein means locations on a vertical axis crossing through the inner lumen, for example axis 920 shown in fig. 9B. Alternatively, the proximal optical assembly is located at the same side, for example at an upper side, of the inner lumen 910 as the distal optical assemblies.

[0280] According to some exemplary embodiments, the vertical axis 920 divides the inner lumen 910 into two identical halves, and is a midline. In some embodiments, the proximal optical assembly is coupled to an inner surface of a wall 922 of the elongated body 902 defining the inner lumen 901 and is positioned at an intersection between the axis 920 and the wall 922. Alternatively, the proximal optical assembly is positioned at a distance of up to 10 cm, for example up to 7 cm, up to 5 cm, up to 3 cm, up to 1 cm, or any intermediate, smaller or larger distance from the intersection. In some embodiments, the proximal optical assembly comprises a plurality of optical assemblies, for example two or more optical assemblies, optionally located closer to the proximal end 910 of the body 902 or closer to the proximal opening 918, as described above with respect to optical assembly 916.

[0281] According to some exemplary embodiments, the proximal optical assembly 916 has a FOV having an angle 920 between 0 degrees and 180 degrees, for example an angle between 30 degrees and 180 degrees, an angle between 30 degrees and 160 degrees, an angle between 90 degrees and 170 degrees, or any intermediate, smaller or larger range of degrees.

[0282] According to some exemplary embodiments, the laryngoscope comprises only one or more proximal optical assemblies with no distal optical assemblies. In some embodiments, one or more of the optical assemblies, for example distal optical assemblies and / or proximal optical assemblies are removably coupled to the laryngoscope body, for example to allow easy attachment and / or easy detachment to the laryngoscope body.

[0283] According to some exemplary embodiments, for example as shown in figs. 9B and 9C, the body 902 comprises a channel for each distal optical assembly, for example channels 922 and 924. In some embodiments, a channel may be used for more than one optical assembly. In some embodiments, each channel has an outer proximal opening, for example, openings 924 and 926 located outside the body 902 and an inner opening, for example opening 928 shown in fig. 10B. In some embodiments, the inner opening of each channel is located within the inner lumen 910 of the body 902 and at a distance smaller than 15 cm, for example smaller than 10 cm, smaller than 5 cm, or any intermediate, smaller or larger distance from the distal opening 930 of the inner lumen 910, or from a distally extending end 912 of the body distal end, for example distance 932 shown in fig. 10B. In some embodiments, each of the channels 922 and 924 is used, for example, for positioning of at least one distal optical assembly at the distal opening of the channel within the inner lumen 910. Additionally, each of the channels 922 and 924 is used, for example, for delivery of wiring between a control unit outside the body 902 and the optical assembly located within the body inner lumen 910.

[0284] According to some exemplary embodiments, the at least one proximal optical assembly 916 is located at a distance 934 from a proximal opening 936 of the inner lumen 910. In some embodiments, distance 934 is shorter than 15 cm, for example shorter than 10 cm, shorter than 5 cm, shorter than 3 cm, or any intermediate, smaller o larger value. Optionally, wiring between the at least one proximal optical assembly pass within at least one channel within the laryngoscope handle 908.

[0285] Reference is now made to fig. 11A depicting a laryngoscope during tissue manipulation, according to some exemplary embodiments of the invention.

[0286] According to some exemplary embodiments, when the laryngoscope, for example the laryngoscope shown in figs. 9A-9D and 10A and 10B, is used for tissue manipulation, the distal opening of laryngoscope is introduced into a throat of a subject, for example a human or an animal subject. In some embodiments, a tissue 1102 of the subject, for example a tissue within the throat, penetrates through the proximal opening 930 partly into the inner lumen 910. In some embodiments, at least one distal optical assembly 915 is used to visualize the tissue 1102 which is positioned within the FOV of the optical assembly 915.

[0287] According to some exemplary embodiments, a tissue manipulating tool 1104 is introduced via the proximal opening 936 into the inner lumen 910 and is optionally advanced down the inner lumen towards the tissue 1102 and the distal opening 930. In some embodiments, the at least one proximal optical assembly 916 is used to visualize the entrance of the tool 1102 via the proximal opening 936 and / or the advancement of the tool 1104 towards the tissuel l02. A potential advantage of having at least one optical assembly close to the proximal opening may be to make sure the tissue manipulating passes within the inner lumen freely, and / or that the tool is not left within the throat when a tissue manipulating procedure is completed.

[0288] According to some exemplary embodiments, for example as shown in fig. 11B, the one or more channels, for example visualization channels 1110 and 1112, the one or more distal optic assemblies and / or the proximal optic assembly 916, block less than 30% of the inner lumen volume of the laryngoscope body defined by the wall 1114, for example block less than 205, block less than 10%, block less than 5% of the inner lumen, or any intermediate, smaller or larger percentage value of the inner lumen volume.

[0289] Exemplary laryngoscope with at least one distal inner optic assembly

[0290] According to some exemplary embodiments, a laryngoscope comprises at least one inner optic assembly, located close to a distal opening of a laryngoscope working channel, and at least partly within the working channel. In some embodiments, the at least one optic assembly comprises an optic sensor, for example a camera facing the working channel distal opening. In some embodiments, the camera is a forward facing camera having a FOV that includes the distal opening.

[0291] According to some exemplary embodiments, the forward facing camera is configured to acquire visual images of the working channel between the axial location of the camera and the distal opening, for example to allow visualization of procedures performed on tissue of the body penetrating into the laryngoscope working channel via the distal opening of the working channel. In some embodiments, in addition to the camera, the optic assembly comprises at least one light source configured and directed to emit light towards the FOV of the camera.

[0292] Reference is now made to figs. 12A-12D, depicting a laryngoscope having at least one distal camera, according to some exemplary embodiments of the invention.

[0293] According to some exemplary embodiments, a laryngoscope 1202 comprises an elongated body 1204 having a distal end 1206 and a proximal end 1208. In some embodiments, the elongated body 1204 is hollow, and has an inner volume 1210 defining a working channel of the laryngoscope 1204, which optionally extends between the distal end 1206 and the proximal end 1208. In some embodiments, the inner working channel 1210 comprises a distal opening 1212 at the distal end 1206 and a proximal opening 1214 at the proximal end 1208.

[0294] According to some exemplary embodiments, the laryngoscope 1202 comprises at least one optics assembly 1216 positioned within the inner volume 1210 having a FOV 1218 between the optics assembly 1216 and the distal opening 1212. In some embodiments, the optics assembly 1216 comprises an optical sensor, for example an optical sensor of a camera, facing the distal opening 1212. In some embodiments, the camera is a forward facing camera, positioned to acquire images of objects, for example tissue 1220 penetrating through the distal opening 1212 into the inner volume 1210. Additionally, the camera is positioned to acquire images of at least one tool, for example a surgical tool, positioned between the camera and the distal opening 1212 within the FOV 1218. In some embodiments, an angle 1219 the FOV 1218 is between 45° degrees and 180° degrees, for example between 90° degrees and 120° degrees, between 110° degrees and 160° degrees, between 130° degrees and 180° degrees, or any intermediate, smaller or larger angle or range of angles.

[0295] According to some exemplary embodiments, the laryngoscope 1202 comprises at least one visualization channel 1222 positioned at least partly within the inner volume 1210. In some embodiments, the channel 1222 comprises a distal opening, for example a distal visualization aperture 1224, and a proximal opening. In some embodiments, the proximal opening of the channel, for example proximal opening 1226, is within the inner volume 1210. Alternatively, the visualization channel crosses through a wall of the 1204, and the proximal opening is located in an outer surface of the body.

[0296] According to some exemplary embodiments, the at least one optics assembly is located at a distance smaller than 15 cm, for example at a distance smaller than 10 cm, smaller than 5 cm, smaller than 2 cm, or any intermediate, smaller or larger distance, from the distal opening 1212, for example distance 1228. In some embodiments, the optics assembly is positioned at least partly within the distal visualization aperture 1224. Optionally, the optics assembly 1216 partly extends from the aperture 1224 into the inner volume 1210.

[0297] According to some exemplary embodiments, the channel 1222 is used to direct electrical wiring from the optics assembly to a location outside the laryngoscope via the proximal opening, for example opening 1226, or an opening in the wall of the body 1204, for example openings 924 or 926 shown in fig. 9C. Optionally, for example as shown in figs. 12D, the proximal opening of the visualization channel, for example opening 1226 is within the inner volume 1210 and near, for example at a distance shorter than 5 cm, for example shorter than 3 cm, shorter than 1 cm, or any intermediate, smaller or larger distance from an opening 1230 in the body 1204, for example in the wall of the body.

[0298] According to some exemplary embodiments, electrical wiring or body of the optics assembly 1216, are isolated from the inner volume by passing within the channel 1222, and exiting through the channel proximal opening, for example opening 1226 and / or body opening 1230. In some embodiments, in case the optics assembly 1216 comprises an endoscope, the endoscope body is positioned within the channel 1222 and exits the channel 1222 and / or the inner volume 1210 via the channel proximal opening 1226 and / or the opening in the body wall, for example body opening 1230. In some embodiments, isolating wiring and / or body of the optics assembly 1216 using the channel 1222 allows, for example, to prevent contact or interference by the optics assembly 1216 with tissue and / or tools within the inner volume, for example during a medical procedure.

[0299] According to some exemplary embodiments, the optics assembly 1216 is fixated and / or anchored within the channel 1222 and / or within the visualization aperture 1224 by at least one fastener or an adhesive material, for example to prevent movement during a medical procedure.

[0300] According to some exemplary embodiments, the optics assembly 1216 is used to generate, for example acquire, a two dimensional (2D) image of the FOV 1218. Optionally, the information acquired by the optics assembly 1216 is combined with information acquired by other one or more optics assemblies, to generate a 3D image of the FOV 1218.

[0301] According to some exemplary embodiments, the laryngoscope 1202 comprises at least one proximal optics assembly 1230 located within the inner volume 1210 and near the proximal opening 1214 of the inner volume, at the proximal end of the 1208 of the body 1204. In some embodiments, a distance 1232 between the proximal optics assembly 1230 and the proximal end 1208 is smaller than 10 cm, for example smaller than 7 cm, smaller than 5 cm, smaller than 3 cm, smaller than 2 cm, smaller than 1 cm, or any intermediate, smaller or larger distance from the proximal end 1208.

[0302] According to some exemplary embodiments, the proximal optics assembly 1230 is a forward facing optics assembly positioned to acquire a FOV 1234 between the proximal optics assembly 1230 and the distal end 1206 of the body 1204, within the inner volume 1210. In some embodiments, an angle 1236 of the FOV 1234 is between 45° degrees and 180° degrees, for example between 90° degrees and 120° degrees, between 110° degrees and 160° degrees, between 130° degrees and 180° degrees, or any intermediate, smaller or larger angle or range of angles. According to some exemplary embodiments, the proximal optics assembly 1230 comprises at least one optic sensor, for example a camera, and / or illumination. Optionally, the proximal optics assembly comprises an endoscope or an optics assembly of an endoscope optionally comprising a camera and / or one or more light emitting diodes (LEDs).

[0303] According to some exemplary embodiments, the laryngoscope 1202 comprises a proximal visualization channel 1238 at least partly within the inner volume 1210. In some embodiments, the channel 1238 comprises a distal opening 1240, for example a distal visualization aperture. In some embodiments, the proximal optics assembly is at least partly positioned within the distal visualization aperture 1240, optionally anchored or fixated to the aperture 1240, in a way similar to as described above with respect to distal optics assembly 1216.

[0304] According to some exemplary embodiments, the proximal visualization channel 1238 is positioned proximally to the at least one visualization channel 1222, within the inner volume 1210. Optionally, the proximal visualization channel 1238 and the at least one visualization channel 1222 are coupled to opposite sides of the inner volume 1210.

[0305] According to some exemplary embodiments, the laryngoscope 1202 comprises a handle 1242, for example an elongated handle, coupled to the body 1204. In some embodiments, the handle 1242 is shaped and sized to be held within a palm of a hand of a subject, for example a human subject. In some embodiments, the handle 1242 is round. In some embodiments, the handle 1242 is hollow and / or comprises a channel or a slit 1244, extending along at least of the handle length. Optionally, the slit 1244 is a slit in the external surface of the handle 1244, and is optionally straight.

[0306] According to some exemplary embodiments, the handle 1242 is coupled to the body 1204 at a location, which is distally to the distal end 1208 of the body 1204. Optionally, the handle 1242 is coupled to the body 1204 at angle 1244 which is equal to about 90° degrees, or is smaller than 90° degrees, for example at angle smaller than 80° degrees, smaller than 70° degrees, smaller than 60° degrees, smaller than 45° degrees, or any intermediate, smaller or larger angle.

[0307] According to some exemplary embodiments, the channel 1222 and / or the visualization aperture 1224 are positioned within the working channel, on a midline 1243 of the laryngoscope. In some embodiments, the midline 1243 optionally defines or is on a virtual plane, optionally transversal plane, optionally vertical relative to a longitudinal axis of the elongated body, crossing the elongated body 1204 and the handle 1242, optionally dividing the laryngoscope into two symmetrical halves. Optionally, the channel 1222 and the channel 1238 are located on the virtual transversal plane, optionally at opposite sides of the working channel inner volume 1210. According to some exemplary embodiments which include at least two visualization channels having at least two distal visualization apertures within the working channel at opposite sides of the working channel, for example, as shown in fig. 9D, the at least two distal visualization apertures are positioned at opposite sides of the virtual plane in a similar minimal distance from the virtual plane and / or from the midline.

[0308] According to some exemplary embodiments, the channel 1238 comprises a proximal opening 1248, within the inner volume 1210 facing the body proximal opening 1214. Alternatively, the channel 1238 crosses through a wall of the body 1205, and has a proximal opening in an external surface of the body 1204. Alternatively, the channel 1238 crosses the wall of the body 1204 into the handle 1242.

[0309] According to some exemplary embodiments, for example as shown in figs. 12A-12D, a proximal opening 1246 of the channel 1238 is within the inner volume 1210 and close to an opening 1248 of the handle slit 1244. In some embodiments, electrical wiring of the optics assembly 1230 exit channel 1238 through the proximal opening 1246 and into the slit 1244 through the slit opening 1248 in the wall of the body 1204 located between the proximal opening 1246 of the channel 1238 and the proximal opening 1214 of the body 1204. Alternatively, the wiring enters into the handle 1242 or into a channel within the handle 1242 via the opening 1246.

[0310] According to some exemplary embodiments, the electrical wiring of the optics assembly 1230 pass within the channel 1238 and within the handle 1242 or within a slit 1244 formed in an external surface of the handle 1244, for example to prevent contact between the electrical wiring and tools inserted into the inner volume via the proximal opening 1214, and / or to prevent interference by the electrical wiring when using the laryngoscope in a medical procedure, for example interference between the electrical wiring and wiring or tools outside the laryngoscope.

[0311] According to some exemplary embodiments, for example as shown in fig. 12A, the distal optics assembly 1224 and the proximal optics assembly are located within the inner volume 1210 at opposite sides of an internal surface of the wall 1205 of the body 1204, and optionally closer to opposite ends of the body 1204.

[0312] According to some exemplary embodiments, a length of the channel 1222 and / or the channel 1238 is at least 2 cm, for example at least 2 cm, at least 5 cm, at least 10 cm, at least 15 cm, or any intermediate, smaller or larger value. In some embodiments, the channel 1238 is shorter than channel 1222.

[0313] According to some exemplary embodiments, the optics assembly within the working channel of the laryngoscope, for example the distal optics assembly and / or the proximal optics assembly block less than 25% of a volume of a cross section of working channel at the location of the optics assembly, for example blocks less than 15% of the volume, less than 10% of the volume, less than 5% of the volume, or any intermediate, smaller or larger percentage value of the volume of a cross-section of the working channel at the location of the optics assembly.

[0314] Reference is now made to fig. 13, depicting images of a laryngoscope having a single visualization channel, according to some exemplary embodiments of the invention.

[0315] According to some exemplary embodiments, fig. 13 panel A, depicts a laryngoscope 1302 which is similar to laryngoscope 1202 shown in figs. 12A-12D. In some embodiments, the laryngoscope 1302 comprises a single visualization channel within a working channel of the laryngoscope. In some embodiments, the laryngoscope 1302 comprises an elongated body 1306 comprising the working channel, and a handle 1306 coupled to the elongated body 1306, optionally to a proximal end 1308, or at a distance smaller than 15 cm, for example at a distance smaller than 10 cm, smaller than 5 cm, smaller than 2 cm, or any intermediate, smaller or larger distance from the proximal end 1308.

[0316] According to some exemplary embodiments, the handle 1306 and the elongated body are integrated, optionally formed as a single unit. Optionally, the handle 1306 and the body 1304 are formed from a polymer material, for example plastic. In some embodiments, for example as shown in fig. 13 panel D showing a front via of the laryngoscope from a distal opening of the working channel, the visualization channel is positioned at an inner surface of the working channel and the body 1304 that is opposite to a surface of the body coupled to the handle 1306.

[0317] According to some exemplary embodiments, for example as also shown in figs. 12A and 12B, a distal opening of the single visualization channel, for example a distal visualization aperture 1216 of channel 1222 or opening 1310 shown in fig. 13 paned D, is located proximally to a distal opening of the working channel, for example opening 1312. In some embodiments, the channel comprises at least one optics assembly, for example an optic sensor, a camera, and / or an optic fiber camera, optionally extending at least partly from the visualization channel through visualization aperture 1216 into the working channel. Alternatively, the optics assembly remains entirely within the visualization channel and has a FOV through the visualization aperture between the optics assembly and the distal opening of the working channel. Additionally, the visualization channel comprises one or more illumination means, for example one or more LEDs, for illuminating the FOV.

[0318] According to some exemplary embodiments, the visualization channel comprises a single optics assembly or two or more optics assemblies. In some embodiments, the single or the two or more optics assemblies are used for generating a 3D image of the FOV before and / or during a procedure that is performed in the throat, when at least the distal end of the laryngoscope is inserted into the throat. In some embodiments, the 3D image is displayed to a subject performing the procedure, or monitoring the procedure in the throat, for example subject 320 shown in fig. 3. In some embodiments, the 3D image is displayed to the subject 320 using display 318 shown in fig- 3.

[0319] According to some exemplary embodiments, the laryngoscope, for example laryngoscope 1302 comprises at least one rear optics assembly 1316, located near a proximal opening 1314 of the working channel, for example as shown in fig. 13 panel C, and in figs. 12A-12D. Optionally, the rear optics assembly, for example assembly 1230 is located at least partly within a rear visualization channel, for example channel 1238, shown in figs. 12A-12D.

[0320] According to some exemplary embodiments, during procedure within the throat using laryngoscope 1302, at least one display, for example display 318 shows, optionally in a split screen view, a 2D or a 3D image of the working channel showing the distal opening of the working channel and / or tissue using signals received from at least one, optionally a single, distal optics assembly positioned within visualization channel 1222, and a different image, for example a working channel view, acquired using at least one rear optics assembly, for example optics assembly 1230. Fig. 13 panels El and E2 show a view acquired using the distal optics assembly.

[0321] According to some exemplary embodiments, the laryngoscope, or a portion thereof, for example the at least one distal optics assembly and / or the rear optics assembly, are disposable. Alternatively, only the laryngoscope body and / or handle are disposable. In some embodiments, the disposable laryngoscope has a body and / or handle portions that are deformable when under pressure levels and / or heat levels used for sterilization by an autoclave or by any medical sterilization device.

[0322] Exemplary visualization of tissue using a laryngoscope having two visualization apertures

[0323] Reference is now made to fig. 14 panels A-E, depicting visualization using a laryngoscope having two spaced visualization apertures.

[0324] According to some exemplary embodiments, a laryngoscope 1402 is similar, for example, to laryngoscope 900 shown in figs. 9A-9D. In some embodiments, for example as shown in fig. 14 panel A, at least one optics assembly, for example a camera, is introduced via a proximal opening 1402 of each side visualization channel. In some embodiments, the optics assembly, each in a different visualization channel is positioned at a distal visualization aperture, for example, as shown in fig. 13 panel B. In some embodiments, the at least two optics assemblies is used to acquire an image of the distal opening of the working channel and / or tissue introduced into the working channel, for example as shown in fig. 14 panels C and D. In some embodiments, the at least two optics assemblies have a partially overlapping FOV, which allows to combine the images shown in fig. 14 panels C and D into a 3D image.

[0325] According to some exemplary embodiments, the laryngoscope 1402 also optionally comprises at least one rear or proximal optics assembly, configured to acquire an image of the working channel, for example as shown in fig. 14 panel E.

[0326] Optionally the images taken by the two spaced-apart distal optics assemblies, for example the images shown in fig. 14 panels C and D, are displayed separately to the subject 320 using at least one display, for example display 318. Alternatively, the images are displayed using different displays. Alternatively, the images are merged to generate a 3D image that is presented, for example using display 318. In some embodiments, for example as described with respect to laryngoscope 1302, at least one image taken by the two distal optics assemblies, and at least one additional image taken by the rear proximal camera are displayed using a single display or separate displays.

[0327] According to some exemplary embodiments, the laryngoscope 1404 or a portion thereof is disposable, for example as described with respect to laryngoscope 1302.

[0328] Exemplary method for visualizing tissue during tissue manipulation

[0329] According to some exemplary embodiments, a laryngoscope is introduced into a throat of a subject, for example a human subject, during a process for manipulation of tissue in the throat. In some embodiments, tissue manipulation comprises at least one of, moving tissue, removing of tissue portion, surgically manipulating tissue, dissecting tissue, or any process performed on a tissue in the throat involving a tool introduced through a working channel of the laryngoscope into the throat.

[0330] According to some exemplary embodiments, the tissue being manipulated is visualized during the tissue positioning in the working channel and / or during tissue manipulation for a time period larger than 5 minutes, for example for a time period larger than 7 minutes, for a time period larger than 10 minutes, for a time period larger than 15 minutes, for a time period larger than 20 minutes, or any intermediate, shorter or longer time period. Additionally, the manipulated tissue is visualized from a stationary optics assembly positioned within the working channel of the laryngoscope. Reference is now made to fig. 15, depicting a process for visualizing tissue during tissue manipulation, according to some exemplary embodiments of the invention.

[0331] According to some exemplary embodiments, a laryngoscope with at least one stationary inner optics assembly is provided at block 1502. In some embodiments, the stationary inner optics assembly is positioned to have a FOV within at least one working channel of the laryngoscope which includes a distal opening of the working channel that is configured to be positioned inside a throat of a subject. In some embodiments, the optics assembly is positioned at a distance of up to 20 cm from the distal opening, for example at a distance of up to 15 cm, at a distance of up to 10 cm, at a distance of up to 5 cm, at a distance of up to 2 cm, or any intermediate, shorter or longer distance from the distal opening.

[0332] According to some exemplary embodiments, the at least one optics assembly is at least partly positioned within the working channel. In some embodiments, the at least one optics assembly comprises at least one of, a camera, and / or an optic sensor. Additionally or optionally, the at least one optics assembly comprises illumination, for example at least one light emitting diode (LED).

[0333] According to some exemplary embodiments, the laryngoscope distal opening, for example the distal opening of the at least one working channel is introduced into the throat, at block 1504.

[0334] According to some exemplary embodiments, a tissue portion of the throat is positioned within the working channel, at block 1506. In some embodiments, the tissue portion is introduced into the working channel via the distal opening. In some embodiments, the tissue portion in the working channel is within the FOV of the at least one optics assembly, for example a distally optics assembly positioned within the working channel of the laryngoscope.

[0335] According to some exemplary embodiments, the tissue portion is visualized during the positioning of the tissue inside the working channel, at block 1508. In some embodiments, the tissue portion is visualized by the at least one stationary optics assembly.

[0336] According to some exemplary embodiments, the tissue inside the working channel is manipulated, at block 1510. In some embodiments, the tissue is manipulated using at least one tool introduced into the laryngoscope working channel, optionally contacting the tissue portion inside the working channel. In some embodiments, the manipulated tissue is visualized at block 1512, during manipulation, optionally during a time period of at least 5 minutes, for example a time period of at least 10 minutes, a time period of at least 15 minutes, a time period of at least 20 minutes, a time period of at least 30 minutes, or any intermediate, shorter or longer time period. In some embodiments, the tissue manipulated is visualized during tissue manipulation by the at least one stationary optics assembly, and from a distance shorter than 20 cm, without removal of the optics assembly from the laryngoscope during tissue manipulation.

[0337] According to some exemplary embodiments, the at least one optics assembly visualizes the FOV continuously during tissue manipulation, or intermittently for a total time period of at least 5 minutes, at least 10 minutes, at least 20 minutes, at least 30 minutes, or any intermediate, shorter or longer overall time period.

[0338] According to some exemplary embodiments, visualizing tissue at block 1508 and / or 1512 comprises imaging the tissue using an imaging technique comprising at least one of, narrow band imaging (NBI), High-Definition (HD) and Ultra High-Definition (4K) Imaging, Chromoendoscopy, Confocal Laser Endomicroscopy (CLE), Fluorescence Endoscopy (FE), Autofluorescence Imaging (AFI), and Endocytoscopy.

[0339] According to some exemplary embodiments, data, for example visual data acquired by the optics assembly from one or more subjects is used for at least one of, generating a database and / or developing a model, for example a machine learning model, optionally an artificial intelligence model.

[0340] According to some exemplary embodiments, visual data acquired by the optics assembly is optionally processed using at least one model, at block 1514. In some embodiments, the visual data is processed using the model, online, optionally at a time period shorter than 5 minutes, for example shorter than 3 minutes, shorter than 1 minute, shorter than 30 seconds, shorter than 10 seconds, shorter than 5 seconds, or any intermediate, shorter or longer time period, from acquiring the data. In some embodiments, the visual data is processed by a control unit receiving signals from the optics assembly, for example control unit 306 shown in fig. 3. Alternatively or additionally, the visual data is processed by a remote device, for example a remote computer in communication with the control unit and / or with the optics assembly. In some embodiments, the visual data is processed using common known algorithm, optionally used to filter, optical focus and / or remove noise information from the visual data.

[0341] According to some exemplary embodiments, a tissue state is optionally determined at block 1316. In some embodiments, the tissue state is optionally determined at block 1316 based on the results of the processing performed at block 1314. In some embodiments, determining tissue state comprises determining tissue content, determining presence of malignant cells and / or tissue, determine presence of a tumor, determine stage of a tumor, and / or determine presence of blood vessels and / or nerves. In some embodiments, the control unit and / or the remote computer delivers a signal, optionally a signal with a human detectable indication which includes the determined tissue state.

[0342] According to some exemplary embodiments, the tissue state is determined online, for example at a time period shorter than 5 minutes, for example shorter than 3 minutes, shorter than 1 minute, shorter than 30 seconds, shorter than 10 seconds, shorter than 5 seconds, or any intermediate, shorter or longer time period, from acquiring the data.

[0343] According to some exemplary embodiments, the signals received from the stationary optics assembly, are optionally automatically processed at block 1314, and the tissue state is optionally automatically determined at block 1316 by optionally automatically applying the model of the signals received from the stationary optics assembly and / or on the results of the processing performed at block 1314. In some embodiments, the tissue state is determined using at least one algorithm, model, formula and / or a look up table, configured to correlate the visual and / or processed visual data with a tissue state.

[0344] Exemplary laryngoscope having reinforced body

[0345] Reference is now made to figs. 16A-16B, depicting a laryngoscope having a rigid body, optionally reinforced body, with one or more optic assemblies, according to some exemplary embodiments of the invention.

[0346] According to some exemplary embodiments, a device, for example a laryngoscope device 1602 comprises a body 1604, optionally an elongated body, optionally a rigid body, having a long axis 1605, a distal section 1606 shaped and sized to be positioned within a subject body, for example within a subject throat, and a proximal section 1608 shaped and sized to be positioned outside the subject body. In some embodiments, the rigid body 1604 comprises a wall defining an inner working channel having a lumen 1610 between the distal section 1606 and the proximal section 1608. In some embodiments, the working channel comprises at least one distal opening 1612 to the working channel lumen 1610 at the distal section 1606, and at least one proximal opening 1614 to the working channel lumen 1610 at the proximal section 1608.

[0347] According to some exemplary embodiments, an overall length of the body 1604 is between 15 cm and 40 cm, for example between 15 cm and 30 cm, between 20 cm and 35 cm, or any intermediate, smaller or larger value. In some embodiments, an outer width, for example outer diameter, of the laryngoscope body 1604 distal end surrounding the distal opening 1612 is between 1 cm and 15 cm, for example between 1 cm and 5 cm, between 5 cm and 10 cm, between 3 cm and 7 cm, or any intermediate, smaller or larger value. In some embodiments, the body 1604 is tapered, having a proximal section 1608, which is wider than the distal section 1606.

[0348] According to some exemplary embodiments, the at least one distal opening 1612 is a front opening, located at a distal end of the body 1604. In some embodiments, the at least one proximal opening 1614 is a rear opening to the working channel lumen 1606 located at a proximal end of the body 1604. In some embodiments, the body 1604 and / or the working channel lumen 1610 is straight along the axis 1605 between the distal opening 1612 and the proximal opening 1614. Alternatively, the body 1604 and / or the lumen 1610 is curved.

[0349] According to some exemplary embodiments, the device comprises at least one handle 1616, in contact with the body 1604 between the distal opening 1612 and the proximal opening 1614. In some embodiments, the handle 1616 is mechanically coupled to the body 1604. Alternatively, the handle 1616 is integrated with the body 1604. In some embodiments, the body 1604 and the handle are formed as a single unit, for example using a single mold or template, or printed, for example 3D printed as a single unit. In some embodiments, the handle 1616 is shaped and sized to be held with a single of a user, for example within a palm of a hand, and has a circular or an oval cross section. In some embodiments, the handle 1616 is tubular or circular.

[0350] According to some exemplary embodiments, the handle 1616, optionally a rigid handle, has a long axis 1618, a first end 1620 contacting the body 1604 and a second opposite end 1622. In some embodiments, the handle 1616 is hollow, having at least one inner lumen 1624. In some embodiments, the inner lumen extends along the axis 1618, optionally between the first end 1620 and the second end 1622.

[0351] According to some exemplary embodiments, an angle 1626 between the handle 1616 and the body 1604 is smaller than 90 degrees, for example smaller than 70 degrees, smaller than 45 degrees, smaller than 30 degrees, or any intermediate, smaller or larger value. In some embodiments, the angle 1626 is between 10 degrees and 90 degrees, for example between 45 degrees and 70 degrees, between 60 degrees and 80 degrees, between 70 degrees and 90 degrees, between 80 degrees and 90 degrees or any intermediate, smaller or larger value.

[0352] According to some exemplary embodiments, the device 1602 comprises one or more reinforcing portions, for example reinforcing portions 1628 and 1630, between the handle 1616 and the body. In some embodiments, the one or more reinforcing portions are rigid portions, rigid enough to prevent bending or movement of the handle 1616 relative to the body 1604, for example when pressing the body 1604 or the body distal section 1606 against body tissue, for example against tissue within the throat. According to some exemplary embodiments, the one or more reinforcing portions, are rigid portions shaped as ribs. In some embodiments, the one or more reinforcing portions are integrated portions of the handle 1616 and the 1604, optionally part of a single unit comprising the handle 1616 and body 1604. In some embodiments, the one or more reinforcing portions comprise at least one reinforcing portion between the handle 1616 and a section of the body 1604 between the handle 1616 and the distal opening 1612, for example reinforcing portion 1628. Alternatively or additionally, the one or more reinforcing portions comprise at least one reinforcing portion between the handle 1616 and a section of the body 1604 between the handle 1616 and the proximal opening 1612, for example reinforcing portion 1630. Optionally, the one or more reinforcing portions are part of the first end 1620 which contact the body 1604 and has a width larger than a width of the opposite second end 1622, of the handle.

[0353] According to some exemplary embodiments, the handle 1616 and / or the body 1604 and / or the one or more reinforcing portions, or at least a portion thereof are formed from at least one polymer, for example PEEK (Polyether ether ketone), Polycarbonate (PC), Polyamide, and / or Polyethylene Terephthalate (PET, PETG). Alternatively or additionally, the handle 1616 and / or the body 1604 and / or the one or more reinforcing portions, or at least a portion thereof, are formed from metal, for example from Titanium and Titanium Alloys, Stainless Steel, Cobalt- Chromium Alloys. Alternatively or additionally, the handle 1616 and / or the body 1604 and / or the one or more reinforcing portions, or at least a portion thereof, are formed from ceramics, for example Zirconia (ZrCE), Alumina (AI2O3), Hydroxyapatite (HA). Alternatively or additionally, the handle 1616 and / or the body 1604 and / or the one or more reinforcing portions, or at least a portion thereof, are formed from Rigid Composite Materials, for example Carbon Fiber- Reinforced PEEK (CFR-PEEK) and / or Glass-Filled Polyamides or Polyesters.

[0354] According to some exemplary embodiments, the body 1604 comprises at least one optics channel 1632 located within the working channel lumen 1610. In some embodiments, the at least one optics channel 1632 comprises at least one distal opening or aperture 1634 facing the distal opening 1612, and at least one proximal opening 1636 facing the proximal opening 1614. In some embodiments, the at least one optics channel 1632 is positioned entirely within the working channel lumen 1610 and is surrounded by the wall of the body 1604. In some embodiments, the at least one distal opening 1634 is located at a distance shorter than 30 cm from the distal opening 1612 of the laryngoscope body 1604, for example at a distance shorter than 20 cm, shorter than 15 cm, shorter than 10 cm, or any intermediate, smaller or larger distance from the opening 1612. According to some exemplary embodiments, the proximal opening 1636 is located at a distance shorter than 30 cm from the proximal opening 1614 the laryngoscope body 1604, for example at a distance shorter than 20 cm, shorter than 15 cm, shorter than 10 cm, or any intermediate, smaller or larger distance from the opening 1614.

[0355] According to some exemplary embodiments, the device 1602 comprises at least one optics assembly 1638 positioned, at least partly within the at least one optics channel 1632. In some embodiments, the at least one optics assembly 1638 comprises at least one camera or an optic sensor located at the distal opening 1634 of the channel 1632. Additionally, the at least one optics assembly 1638 comprises one or more illumination source, for example a light-emitting diode (LED), or a tip of an optics fiber. In some embodiments, the one or more illumination source is positioned at the distal opening 1634. In some embodiments, the channel 1632 comprises at least 2 channels, one for the camera, at least one camera channel, and one for the illumination source, at least one illumination channel. Optionally, the channel comprises at least 3 channels, one channel, optionally a central channel, comprises the camera and the camera wiring, and two channels, each comprise an illumination source, for example an optic fiber. In some embodiments, the illumination channels are located at opposite side of the central camera channel, and optionally have a shared lumen. Optionally, the optics assembly 1638 is reversibly coupled to the body 1604, optionally within the at least on channel 1632, for example to allow reuse of the optics assembly 1638. Alternatively, the optics assembly 1638 is irreversibly coupled to the body 1604, for example to make the laryngoscope a single use device. In some embodiments, irreversibly coupling means that an attempt for decoupling requires a force that breaks or disassembles a fastener and / or one or more components of the laryngoscope.

[0356] According to some exemplary embodiments, the channel 1632 or each channel of the optics or the illumination channels comprise at least one fastener at the distal opening 1634 or near the distal opening 1634, for fastening a camera and / or an illumination source, for example a tip of the illumination source. Optionally, in some embodiments where the at least one channel 1632 comprises at least one camera channel and at least one illumination channel, each channel comprises a separate fastener for fastening a camera to the body 1604 and a separate fastener for fastening the illumination source to the body 1604.

[0357] According to some exemplary embodiments, the at least one optics channel 1632 defines a passage for introduction of a camera and / or at least one light emitting source, for example at last one optics fiber, into the working channel lumen, to a position close to the distal opening 1612. In some embodiments, the at least one optics channel is partially opened along the length of the at least one optics channel, having an arc shape surrounding at least 30% of the passage, for example at least 50%, at least 70%, at least 90% of the passage.

[0358] According to some exemplary embodiments, the at least one optics channel 1632 comprises 2 or more optics channels, for example 2, 3, 4, 5 or any larger number of optics channels, each having a distal opening and a proximal opening, optionally in a similar size and / or location to the distal opening 1634 and to the proximal opening 1636. In some embodiments, the optics channels contact each other, for example 2 optics channel share a wall. Alternatively or additionally, at least some or all of the optics channels are separate, spaced-apart optics channels. In some embodiments, the optics channels have the same length within the working channel lumen 1610. Alternatively, one or more of the optics channels have a different length. In some embodiments, the optics channels comprise at least one optics channel, for example to allow introduction of a camera and wiring into the lumen 1610. Optionally, the camera and / or or the wiring extend out form the distal opening of the channel, for example via distal opening. In some embodiments, the optics channels comprise at least one illumination channel, for example to allow introduction of a light source and wiring into the lumen 1610. In some embodiments, having a at least one optics channel, for example at least one camera channel and / or at least one visualization channel allows, for example, to prevent contact between the optics and wiring travelling within the at least one optics channel, and at least one tool, for example a surgical tool or an examination tool, introduced into the working channel lumen 1610 during a medical procedure.

[0359] According to some exemplary embodiments, the camera of the distal optics assembly comprises an endoscope camera, having a distal tip with a width value between 1 mm and 6 mm. In some embodiments, the illumination source comprises an optic fiber having a width value of between 1 mm and 3 mm.

[0360] According to some exemplary embodiments, the body 1604 comprises at least one opening 1639 in the body wall. In some embodiments, the opening 1639 is positioned at a distance of less than 20 cm, for example less than 10 cm, less than 5 cm, or any intermediate, shorter or longer distance from the proximal opening 1636 of the channel 1632. In some embodiments, the opening 1639 is wide enough to allow passage of the illumination wiring, for example passage of the optic fibers out from the working channel lumen 1610, optionally to allow connection of the optic fibers positioned within the at least one channel 1632 to at least one external illumination source unit 1640. Alternatively or additionally, the opening 1639 is wide enough to allow passage of the camera wiring out from the working channel lumen 1610, optionally to allow connection of the camera positioned within the at least one channel 1632, to at least one external visualization unit 1642. In some embodiments, the visualization unit 1642 is configured to generate an image, for example a two dimensional (2D) image, or a 3D image, based on signals received from at least one distal camera positioned at the channel 1632, optionally at the proximal opening 1634 or partially extends therethrough. In some embodiments, the image is an image of a FOV between the distal opening 1634 and the distal opening 1612. Additionally or optionally, the visualization unit 1642 is configured to generate an image, for example a 2D image, or a 3D image, based on signals received from at least one proximal camera of the optics 1644, optionally positioned up to 10 cm, up to 5 cm, up to 2 cm, or any intermediate, shorter or longer distance from the proximal opening 1614. In some embodiments, the image is an image of a FOV between the proximal camera of optics 1644 and the distal opening 1612.

[0361] According to some exemplary embodiments, the device 1602 comprises at least one proximal optics assembly 1644 positioned within the working channel lumen 1610, at a distance shorter than 10 cm, for example shorter than 5 cm, shorter than 1 cm or any intermediate, smaller or larger distance value form the proximal opening 1614. In some embodiments, the at least one proximal optics assembly comprises at least one camera, for example an endoscopic camera optionally having a distal tip with a width value between 1 mm and 6 mm. Additionally or optionally, the proximal optics assembly comprises at least one illumination source, for example a LED or a tip of an optic fiber.

[0362] According to some exemplary embodiments, wiring of the proximal optics assembly 1644 extend out from the working channel lumen 1610 via the proximal opening 1614, and / or via an inner channel within the handle 1616.

[0363] According to some exemplary embodiments, the proximal optics assembly 1644 is coupled directly to the body 1604 using at least one fastener. Alternatively, the proximal optics assembly 1644 is coupled to an optics assembly holder, for example holder 1646. In some embodiments, the holder 1646 is configured to be coupled to a guiding connector, for example an extension or a slot in the body 1602. In some embodiments, the guiding connector is integrated with the body 1604 and optionally extends from an inner surface of the body 1604 within the working channel lumen 1610.

[0364] According to some exemplary embodiments, the guiding connector comprises an extension, for example an elongated extension, complementary to an elongated slot in the holder 1646. Alternatively or additionally, the guiding connector comprises a slot, for example an elongated slot, which is complementary to a protrusion, for example an elongated protrusion of the holder 1646. In some embodiments, the holder is reversibly coupled to the body 1604, for example in a way that allows decoupling of the optics assembly form the body 1604, optionally during and / or following a procedure that uses the laryngoscope 1602. A potential advantage of having a holder that is reversibly coupled to the body 1604 may be to allow re-use of the optics assembly 1644. Alternatively, the optics assembly 1644 or the holder 1646 is irreversibly coupled to the body 1604, as described with respect to optics assembly 1638.

[0365] According to some exemplary embodiments, the laryngoscope 1602 is connectable to the at least one visualization unit 1642 and / or the at least one illumination source unit 1640. In some embodiments, the laryngoscope 1602 is part of a system comprising the visualization unit 1642 and / or the illumination source unit 1640.

[0366] According to some exemplary embodiments, one or more of the components of laryngoscope 1602, for example body 1604, handle 1616 and the at least one channel 1632 within the body, are formed using printing, for example three dimensional (3D) printing and / or using injection molding. Optionally, the laryngoscope, for example laryngoscope 1602 or a portion thereof, for example body 1604, handle 1616 and / or the at least one channel 1632 is personalized for a specific subject using measurements taken from the subject using, for example an imaging device or using one or more images of the subject throat. Optionally, the laryngoscope, for example laryngoscope 1602 or a portion thereof, for example body 1604, handle 1616 and / or the at least one optics assembly coupled to the laryngoscope is disposable, and designed to be disposed after use and / or after interaction with a subject body.

[0367] According to some exemplary embodiments, the laryngoscope 1602 is provided as a kit. In some embodiments, the kit comprises the body 1604 and the handle 1616, optionally integrated as a single unit, optionally generated by 3D printing or by molding, for example injection molding. In some embodiments, the kit further comprises at least one camera, for example an endoscopic camera, and at least one illumination source, for example at least one optics fiber, configured to be introduced via the at least one optics channel 1632, optionally comprises at least 2 channels one for the camera and one for the illumination source. In some embodiments, the kit further comprises the proximal optics 1644, for example a camera, optionally an endoscopic camera. In some embodiments, the kit further comprises the optics holder 1646. In some embodiments, during the assembly of the kit components into a visualization laryngoscope, the proximal optics 1644 is coupled to the body 1604, optionally directly, or via the holder 1646. In some embodiments, during the assembly of the visualization laryngoscope, at least one camera and at least one visualization source are introduced into the channel 1632 and fixedly positioned in the distal opening 1634 and / or extend at least partly via the distal opening 1634. In some embodiments, the at least one camera and / or the at least one visualization source are introduced into the channel 1632, optionally into different channels, one for the at least one camera, and one for the at least one visualization source. In some embodiments, the at least one camera and / or the at least one visualization source are introduced into the channel 1632 via the proximal opening 1614 of the working channel, or via at least one side opening in the body 1604 wall, for example side opening 1639.

[0368] According to some exemplary embodiments, for example as shown in fig. 16B, a length 1611 of the laryngoscope elongated body 1604 is between about 100 mm and about 220 mm, for example between about 110 mm and about 200 mm, between about 150 mm and about 200 mm, between about 160 mm and about 190 mm, or any intermediate, smaller or larger value. In some embodiments, during a procedure in which the laryngoscope body 1604 is at least partly introduced into a throat of a subject, for example a human subject, up to about 130 mm, up to about 180 mm, up to about 110 mm, up to about 100 mm, or any intermediate, smaller or larger value, of the body 1604 measured from the distal opening 1612 are introduced into the throat.

[0369] According to some exemplary embodiments, a length of a working channel lumen 1610 through which tools are introduced via the laryngoscope working channel into the throat during a procedure, have a length 1613 between the distal opening 1612 and the proximal opening 1614, of between about 50 mm and about 220 mm, for example between about 110 mm and about 200 mm, between about 150 mm and about 200 mm, between about 160 mm and about 190 mm, or any intermediate, smaller or larger value. In some embodiments, a minimal length 1613 of the working channel is at least 50 mm, for example at least 70 mm, at least 100 mm, at least 120 mm, or any intermediate, smaller or larger value.

[0370] According to some exemplary embodiments, a minimal width of the working channel is at least 10 mm, for example at least 12 mm, at least 20 mm, or any intermediate, smaller or larger value. In some embodiments, a width of the working channel is between 10 mm, and a maximal width of the proximal opening 1614 and the distal opening 1612.

[0371] According to some exemplary embodiments, a width 1615, for example a minimal width of the distal opening 1612, a minimal width of the working channel, or of a distal tip of the body 1604, is between about 12 mm and about 60 mm, for example between about 15 mm and about 25 mm, between about 18 mm and about 22 mm, or any intermediate, smaller or larger value. In some embodiments, a width 1617, for example a minimal width of the proximal opening 1614, is between about 12 mm and about 50 mm, for example between about 15 mm and about 40 mm, between about 18 mm and about 40 mm, or any intermediate, smaller or larger value. In some embodiments, the width of the body 1604 is suitable to fit into a throat of a subject, for example an adult subject above 18 years old, or into a throat of a young subject under 18 years old, without causing damage or permanent damage to tissue of the throat surrounding the elongated body 1604.

[0372] According to some exemplary embodiments, a length of the at least one optics channel 1632 is between about 40 mm and about 180 mm, for example between about 40 mm and about 100 mm, between about 50 mm and about 120 mm, between about 90 mm and about 180 mm, or any intermediate, smaller or larger value. In some embodiments, the length 1619 of the at least one optics channel 1632 is shorter than the length 1613 of the working channel or of the elongated body 1604. Alternatively, the length 1619 is similar to the length 1613 or to the length of the elongated body 1604. In some embodiments, the at least one optics channel 1632 is axial and straight, aligned along long axis 1605 of the elongated body 1604. In some embodiments, the proximal opening 1636 is positioned within the working channel lumen 1610, or at the proximal opening 1614 of the working channel, or in a wall of the elongated body 1604, or outside the elongated body 1604, for example incase that the optics channel extends through the elongated body wall and outside the elongated body 1604.

[0373] According to some exemplary embodiments, a width of the distal opening 1634 of the at least one optics channel is between about 1.5 mm and about 15 mm, for example between about 1.5 mm and about 10 mm, between about 2 mm and about 8 mm, or any intermediate, smaller or larger value. In some embodiments, a width of the proximal opening 1636 of the at least one optics channel is between about 1.5 mm and about 15 mm, for example between about 1.5 mm and about 10 mm, between about 2 mm and about 8 mm, or any intermediate, smaller or larger value.

[0374] According to some exemplary embodiments, a width of a proximal opening or a distal opening of at least one illumination channel of the at least one optics channel 1632 is between about 1.5 mm and about 5 mm. In some embodiments, a width of a proximal opening or a distal opening of at least one camera channel of the at least one optics channel 1632, is between about 1.5 mm and about 20 mm

[0375] According to some exemplary embodiments, the opening 1634, for example at least one visualization aperture is positioned proximally to the proximal opening 1612, at a distance 1621 of between about 0.1 cm and about 15 cm, for example at a distance between about 0.1 cm and about 10 cm, between about 0.5 cm and about 15 cm, or any intermediate, smaller or larger value. In some embodiments, the opening 1636 of the at least one optics channel 1632 is positioned distally to the proximal opening 1614, at a distance 1623 of between about 0.1 cm and about 15 cm, for example at a distance between about 0.1 cm and about 10 cm, between about 0.5 cm and about 15 cm, or any intermediate, smaller or larger value.

[0376] According to some exemplary embodiments, the handle 1616 has a length 1625 between first end 1620 and opposite end 1622, of between about 20 mm and about 250 mm, for example of between about 20 mm and about 100 mm, between about 50 mm and about 150 mm, between about 100 mm and about 150 mm, or any intermediate, smaller or larger value. In some embodiments, an outer width 1627 of the handle 1627, for example a minimal value of a width aspect of the handle is between 10 mm and 50 mm, for example between 10 mm and 30 mm, between 15 mm and 25 mm, or any intermediate, smaller or larger value.

[0377] Reference is now made to figs. 16C-16H depicting different views of a laryngoscope body including an integrated handle, according to some exemplary embodiments of the invention.

[0378] According to some exemplary embodiments, a laryngoscope body 1650 comprises an elongated hollow body 1652, optionally rigid, having a distal section 1654 and a proximal section 1656. In some embodiments, the body 1650 comprises an integrated elongated handle 1658, optionally contacting the body 1652 between the proximal section 1656 and the distal section 1654. In some embodiments, the handle 1658 is shaped and sized to be held within a palm of a hand, and is oriented at an angle smaller than 90 degrees, relative to the body 1652. Optionally, the handle 1658 is hollow.

[0379] According to some exemplary embodiments, the laryngoscope body 1650 comprises one or more structurally reinforcing portions, optionally shaped as ribs, between the handle 1658 and the body 1652, for example reinforcing portions 1660, and 1662, located at a connection region between the handle 1658 and the elongated body 1652. Optionally, the handle 1658 terminated with a curved, arc shaped-extension 1664, shaped to receive a finger of a user holding the laryngoscope body 1650. In some embodiments, the extension is curved towards the body 1652.

[0380] According to some exemplary embodiments, the elongated body 1650 comprises an inner working channel, extending between the proximal section 1656 and the distal section 1654. In some embodiments, the working channel comprises a distal opening 1664, optionally having a triangle cross-section for example as shown in fig. 16D, and a proximal opening 1666, optionally having an oval cross-section for example as shown in fig. 16H.

[0381] According to some exemplary embodiments, the elongated body 1652 comprises a proximal extension 1668, for example a guiding extension, extending proximally to the proximal opening 1666. In some embodiments, the guiding extension 1668 is shaped and sized to fit within a slot of a holder 1670, for example a camera holder. In some embodiments, the holder 1670 is configured to be coupled to an optic sensor assembly, for example a camera and to couple the optic sensor assembly to the laryngoscope body 1650 via the extension 1668. In some embodiments, the holder 1670 is removably coupled to the extension 1668, for example a holder connector.

[0382] According to some exemplary embodiments, the elongated body 1652 comprises a proximal opening in a wall of the body 1652, for example opening 1672. In some embodiments, the opening 1672, for example as shown in fig. 16D, is shaped as a slot or a cut in the wall extending from the proximal opening 1666.

[0383] According to some exemplary embodiments, for example as shown in figs. 16F and 16G, the elongated body 1652 comprises at least one inner optics passage 1676, optionally shaped as an enclosed channel or a partially enclosed channel, for example the optics channel 1632 shown in fig. 16A. In some embodiments, the passage 1676 has a distal opening 1678 located proximally to the distal opening 1664, and a proximal opening 1680 located distally to the proximal opening 1666 and optionally to the opening 1672. In some embodiments, the passage 1676 is located entirely within the working channel lumen.

[0384] According to some exemplary embodiments, for example as shown in figs. 16G and 16H, the at least one optics passage 1676 comprises a central passage 1684, optionally for introduction of a camera, and two passages 1686 and 1688, optionally at opposite sides of the central passage. In some embodiments, the two passages 1686 and 1688 are shaped and sized to receive optic fibers, or other light sources.

[0385] According to some exemplary embodiments, for example s shown in figs. 16F-16H, the holder 1670 for the proximal optics assembly, for example a proximal camera, is located at the proximal opening 1666, and optionally extends through the opening 1666. In some embodiments, the optics passage 1676 comprising passages 1684, 1686 and 1688, are located at a different angular position within the working channel lumen 1682, optionally at opposite angular positions.

[0386] According to some exemplary embodiments, for example as shown in fig. 16G showing a rear view of the laryngoscope body, the elongated body 1652 proximal section has an oval cross section, and a distal section with a rectangular cross section. According to some exemplary embodiments, the laryngoscope body 1650 is manufactured by printing, for example by 3D printing, or using ay mass production technique, for example by injection molding.

[0387] Exemplary optics assembly

[0388] Reference is now made to figs. 17A and 17B, depicting assembly of a laryngoscope, according to some exemplary embodiments of the invention.

[0389] According to some exemplary embodiments, optic fibers 1702 and 1704, are introduced via the proximal section 1656 into at least one passage, or two separate passages within the laryngoscope working channel. In some embodiments, a proximal camera 1706 is coupled to a holder 1708, and the holder is coupled to a holder connector, or a guide in the elongated body 1652, optionally located at the proximal opening of the laryngoscope working channel, for example as shown in figs. 16A-16E.

[0390] According to some exemplary embodiments, a distal front camera 1710 is coupled to the elongated body 1652 by introducing the camera through the distal opening of the elongated body 1652. Alternatively, the distal front camera is introduced into a passage, via a an opening in the body 1652, for example opening 1672 shown in figs. 16D and 16E.

[0391] Optionally, one or both of the at least one front camera 1710 and the at least one rear proximal camera 1706 are wireless cameras. Optionally, images taken by one or more of the cameras can be visualized using a cellular device, a remote display, or on several displays, optionally simultaneously. In some embodiments, the one or more of the cameras coupled to the laryngoscope are connected using a Universal Serial Bus (USB) connector, or any other connector. In some embodiments, the illumination, for example the optic fibers are connected to an illumination source or to the laryngoscope via a quick connector. In some embodiments, a visualization unit connected to the one or more cameras uses a software suitable for endoscope cameras.

[0392] It is expected that during the life of a patent maturing from this application many relevant laryngoscopes, optic sensors, illumination sources will be developed; the scope of the terms laryngoscope, optic sensor, and illumination source are intended to include all such new technologies a priori.

[0393] As used herein with reference to quantity or value, the term “about” means “within ± 10

[0394] % Of’. The terms “comprises”, “comprising”, “includes”, “including”, “has”, “having” and their conjugates mean “including but not limited to”.

[0395] The term “consisting of’ means “including and limited to”.

[0396] The term “consisting essentially of’ means that the composition, method or structure may include additional ingredients, steps and / or parts, but only if the additional ingredients, steps and / or parts do not materially alter the basic and novel characteristics of the claimed composition, method or structure.

[0397] As used herein, the singular forms “a”, “an” and “the” include plural references unless the context clearly dictates otherwise. For example, the term “a compound” or “at least one compound” may include a plurality of compounds, including mixtures thereof.

[0398] Throughout this application, embodiments of this invention may be presented with reference to a range format. It should be understood that the description in range format is merely for convenience and brevity and should not be construed as an inflexible limitation on the scope of the invention. Accordingly, the description of a range should be considered to have specifically disclosed all the possible subranges as well as individual numerical values within that range. For example, description of a range such as “from 1 to 6” should be considered to have specifically disclosed subranges such as “from 1 to 3”, “from 1 to 4”, “from 1 to 5”, “from 2 to 4”, “from 2 to 6”, “from 3 to 6”, etc.; as well as individual numbers within that range, for example, 1, 2, 3, 4, 5, and 6. This applies regardless of the breadth of the range.

[0399] Whenever a numerical range is indicated herein (for example “10-15”, “10 to 15”, or any pair of numbers linked by these another such range indication), it is meant to include any number (fractional or integral) within the indicated range limits, including the range limits, unless the context clearly dictates otherwise. The phrases “range / ranging / ranges between” a first indicate number and a second indicate number and “range / ranging / ranges from” a first indicate number “to”, “up to”, “until” or “through” (or another such range-indicating term) a second indicate number are used herein interchangeably and are meant to include the first and second indicated numbers and all the fractional and integral numbers therebetween.

[0400] Unless otherwise indicated, numbers used herein and any number ranges based thereon are approximations within the accuracy of reasonable measurement and rounding errors as understood by persons skilled in the art.

[0401] As used herein the term “method” refers to manners, means, techniques and procedures for accomplishing a given task including, but not limited to, those manners, means, techniques and procedures either known to, or readily developed from known manners, means, techniques and procedures by practitioners of the chemical, pharmacological, biological, biochemical and medical arts.

[0402] As used herein, the term “treating” includes abrogating, substantially inhibiting, slowing or reversing the progression of a condition, substantially ameliorating clinical or aesthetical symptoms of a condition or substantially preventing the appearance of clinical or aesthetical symptoms of a condition.

[0403] It is appreciated that certain features of the invention, which are, for clarity, described in the context of separate embodiments, may also be provided in combination in a single embodiment. Conversely, various features of the invention, which are, for brevity, described in the context of a single embodiment, may also be provided separately or in any suitable subcombination or as suitable in any other described embodiment of the invention. Certain features described in the context of various embodiments are not to be considered essential features of those embodiments, unless the embodiment is inoperative without those elements.

[0404] Although the invention has been described in conjunction with specific embodiments thereof, it is evident that many alternatives, modifications and variations will be apparent to those skilled in the art. Accordingly, it is intended to embrace all such alternatives, modifications and variations that fall within the spirit and broad scope of the appended claims.

[0405] All publications, patents and patent applications mentioned in this specification are herein incorporated in their entirety by reference into the specification, to the same extent as if each individual publication, patent or patent application was specifically and individually indicated to be incorporated herein by reference. In addition, citation or identification of any reference in this application shall not be construed as an admission that such reference is available as prior art to the present invention. To the extent that section headings are used, they should not be construed as necessarily limiting. In addition, any priority document(s) of this application is / are hereby incorporated herein by reference in its / their entirety.

Claims

WHAT IS CLAIMED IS:

1. A laryngoscope device, comprising: an elongated body having a long axis, a distal section shaped and sized to be positioned within a throat of a subject, and a proximal section shaped and sized to be positioned outside said throat, wherein a wall of said elongated body defines and surrounds a working channel having at least one proximal opening at said proximal section, and at least one distal opening at said distal section; at least one optics channel positioned within said working channel, wherein said optics channel has at least one distal visualization aperture facing the at least one distal opening of said working channel, and at least one proximal opening; at least one distal optics assembly, comprising at least one distal camera, positioned within said at least one optics channel and proximally to the at least one distal opening of the working channel, to have a first field of view (FOV) between said at least one distal visualization aperture and said working channel distal opening, wherein said at least one camera is configured to acquire an image of said first field of view.

2. A device according to claim 1, wherein a length of said at least one optics channel is shorter than a length of said working channel.

3. A device according to any one of claims 1 or 2, wherein said at least one distal visualization aperture of said at least one optics channel is located at a distance between 0.1 cm and 15 cm from the distal opening of said working channel.

4. A device according to any one of claims 1 or 2, wherein said proximal opening of said at least one optics channel is located within the working channel and positioned at a distance shorter than 15 cm from the proximal opening of the working channel.

5. A device according to any one of the previous claims, wherein said at least one optics channel is coupled to the elongated body or is integrated with the elongated body wall.

6. A device according to any one of the previous claims, comprising at least one illumination source, wherein said at least one optics channel comprises a plurality of channels, wherein said plurality of channels comprise at least one camera channel shaped and sized to receive said atleast one camera, and at least one illumination channel shaped and sized to receive said at least one illumination source.

7. A device according to claim 6, wherein said at least one illumination source is positioned in a distal opening of said at least one illumination channel to emit and direct light to said first FOV.

8. A device according to claim 7, wherein a distal opening of said at least one camera channel has the same axial position within said working channel as said distal opening of said at least one illumination channel.

9. A device according to any one of claims 7 or 8, comprising at least one illumination source fastener configured to fixedly fasten said at least one illumination source to said at least one illumination channel and / or to said distal opening of said at least one illumination channel.

10. A device according to any one of claims 6 to 9, comprises at least one camera fastener configured to fixedly fasten said at least one camera to said at least one camera channel and / or to said at least one distal visualization aperture.

11. A device according to any one of claims 6 to 9, wherein said at least one camera channel and said at least one illumination channel contact each other along at least 50% of their length.

12. A device according to any one of claims 6 to 11, wherein said at least one illumination channel comprises at least two illumination channels, each is shaped and sized to receive a separate illumination source.

13. A device according to claim 12, wherein each of said at least two illumination channels is located at an opposite side of said at least one camera channel.

14. A device according to any one of claims 6 to 13, wherein said at least one illumination source comprises at least one optic fiber.

15. A device according to any one of the previous claims, comprising at least one proximal optics assembly positioned within said working channel at a distance shorter than 10 cm from said working channel proximal opening, wherein said at least one proximal optics assembly comprises at least one proximal camera positioned to have a second FOV between said at least one proximal optics assembly and said working channel distal opening, and is configured to acquire an image of said second FOV.

16. A device according to claim 15, wherein said at least one proximal optics assembly is positioned between said proximal opening of said working channel and said proximal opening of said distal optics channel.

17. A device according to any one of claims 15 or 16, comprising at least one proximal fastener configured to fasten said at least one proximal optics assembly to said elongated body.

18. A device according to claim 17, wherein said at least one proximal fastener is integrated with said elongated body.

19. A device according to any one of claims 15 or 16, comprising a proximal optics assembly holder configured to be coupled to said at least one proximal optics assembly; wherein said elongated body comprises an elongated guide extending from said elongated body through said working channel proximal opening, wherein said proximal optics assembly holder is shaped to be mechanically coupled to said elongated guide.

20. A device according to claim 19, wherein said elongated guide is integrated with said elongated body.

21. A device according to any one of claims 15 to 20, wherein said at least one proximal camera is located proximally to said at least one distal camera, within said working channel.

22. A device according to any one of claims 15 to 21, wherein said at least one proximal camera and said at least one distal camera, are located at opposite angular locations within said working channel.

23. A device according to any one of the previous claims comprising an elongated rigid handle in contact with an outer surface of said elongated body at a contact location between said distal opening and said proximal opening of said working channel, wherein said elongated rigid handle is shaped and sized to be held within a palm of a subject hand.

24. A device according to claim 23, wherein said elongated rigid handle is oriented in an angle of between 45 degrees and 90 degrees relative to a portion of the elongated body between said contact location and said distal section of said elongated body.

25. A device according to any one of claims 23 or 24, comprising one or more rigid reinforcement portions interconnecting said elongated rigid handle and said elongated body, wherein said one or more rigid reinforcement portions are configured to reinforce said contact point to resist movement of said elongated rigid handle relative to said elongated body.

26. A device according to any one of claims 23 or 24, wherein said elongated body is integrated with said handle.

27. A device according to claim 26, wherein said elongated body and said handle are formed from at least one polymer material.

28. A device according to claim 27, wherein said at least one polymer material comprises at least one of, Polyether ether ketone (PEEK), Polycarbonate (PC), Polyamide, Polyethylene Terephthalate (PET) and / or , Polyethylene Terephthalate Glycol-Modified (PETG).

29. A device according to any one of claims 26 to 28, wheren said elongated body and said handle are formed as a single unit in a three dimensional (3D) printing process, or in an injection molding process.

30. A device according to any one of the previous claims, wherein said working channel between said distal opening and said proximal opening is straight.

31. A device according to any one of the previous claims, wherein a minimal width of said working channel is at least 12 mm.

32. A laryngoscope device, comprising: an elongated rigid body having a long axis, a distal section shaped and sized to be positioned within a throat of a subject, and a proximal section shaped and sized to be positioned outside said throat, wherein a wall of said elongated body defines and surrounds a working channel having at least one proximal opening at said proximal second, and at least one distal opening at said distal section; at least one optics channel positioned within said working channel and integrated with said elongated rigid body; an elongated rigid handle in contact with an outer surface of said elongated body, wherein said elongated rigid handle is shaped and sized to be held within a palm of a subject hand; wherein said elongated rigid body, said at least one optics channel and said elongated rigid handle are manufactured as a single unit from at least one polymer material.

33. A device according to claim 32, wherein said at least one polymer material comprises at least one of, Polyether ether ketone (PEEK), Polycarbonate (PC), Polyamide, Polyethylene Terephthalate (PET) and / or , Polyethylene Terephthalate Glycol-Modified (PETG).

34. A device according to any one of claims 32 or 33, wherein said elongated rigid body, said at least one optics channel and said elongated rigid handle are manufactured as a single unit in a three dimensional (3D) printing process or in an injection molding process.

35. A device according to any one of claims 32 to 34, wherein a minimal length of said working channel is at least 50 mm.

36. A device according to any one of claims 32 to 35, wherein a minimal width of said working channel is at least 12 mm.

37. A laryngoscope device, comprising: an elongated rigid body having a distal end shaped and sized to penetrate into a throat of a subject, and a proximal end shaped and sized to be positioned outside said throat, wherein a wall of said elongated rigid body defines and surrounds a working channel having at least one proximal opening at said proximal end, and at least one distal opening;at least one distal optics assembly comprising at least one distal camera, positioned within said working channel at a distance between 0.1 cm and 15 cm from said distal opening, wherein said at least one distal optics assembly is positioned to visualize a FOV between said at least one distal optics assembly and said working channel distal opening; at least one proximal optics assembly comprising at least one proximal camera, positioned within said working channel between said at least one distal optics assembly and said working channel proximal opening, wherein said at least one proximal optics assembly is configured to visualize a FOV between said at least one proximal optics assembly and said distal opening of said working channel.

38. A device according to claim 37, wherein said at least one proximal optics assembly is positioned at a distance shorter than 10 cm from said working channel proximal opening.

39. A device according to any one of claims 37 or 38, wherein said at least one proximal optics assembly is positioned proximally to said at least one distal optics assembly, within said working channel.

40. A device according to any one of claims 37 to 39, wherein each of said at least one proximal optics assembly and said at least one distal optics assembly are coupled directly or indirectly to an inner surface of said elongated rigid body by at least one fastener or adhesive.

41. A device according to any one of claims 37 to 40, wherein a minimal length of said working channel is at least 50 mm, and wherein a minimal width of said working channel is at least 12 mm.

42. A laryngoscope device, comprising: an elongated rigid body having a distal end shaped and sized to penetrate into a throat of a subject, and a proximal end shaped and sized to be positioned outside said throat, wherein a wall of said elongated rigid body defines and surrounds a working channel having at least one proximal opening at said proximal end, and at least one distal opening, wherein said at least one proximal opening is shaped and sized to receive a tissue manipulating tool into said working channel;at least one proximal optics assembly positioned within said working channel coupled to said wall and at a distance shorter than 10 cm from said working channel proximal opening, wherein said at least one proximal optics assembly is configured to visualize a FOV between said at least one proximal optics assembly and said distal opening of said working channel.

43. A device according to claim 42, wherein a minimal length of said working channel is at least 50 mm.

44. A device according to any one of claims 42 or 43, wherein a minimal width of said working channel is at least 12 mm.

45. A method for visualizing tissue within a throat, comprising: introducing a laryngoscope having an elongated rigid body with at least one inner working channel, into a throat of a subject positioning following or during said introducing a distal opening of said inner working channel within said throat, and a proximal opening of said inner working channel outside said throat; visualizing a first field of view (FOV) within said inner working channel by at least one distal optics assembly comprising a distal camera positioned within said inner working channel at a distance of between 0.1 cm and 10 cm from said distal opening of said inner working channel, and a second FOV within said inner working channel by at least one proximal optics assembly comprising a proximal camera positioned between said proximal opening of said inner working channel and said distal camera.

46. A method according to claim 45, comprising: displaying during aid visualizing at least one image of said first FOV and of said second FOV based on signal received from said distal camera and said proximal camera.

47. A method according to claim 46, wherein said at least one image comprises a two dimensional image (2D) image or a three dimensional (3D) image.

48. A method according to any one of claims 46 or 47, wherein said at least one image comprises at least one first image of said first FOV and at least one seond image of said second FOV.

49. A method according to any one of claims 46 to 48 comprising, manipulating during said displaying tissue of said throat using a tool introduced into said inner working channel via said inner working channel proximal opening.

50. A method according to claim 49, wherein said manipulating comprises at least one of, removing polyps from vocal cords, removal of benign lesions, and removal of malignant lesions.

Images