Hydrogel material, preparation method therefor, and use thereof

Abstract

Disclosed are a hydrogel material, a preparation method therefor, and a use thereof. The hydrogel material comprises the following raw materials: an epoxy resin, a curing agent, an amino acid metal complex, a glucose oxidase solution, and a precursor solution. The precursor solution comprises glucose, a cross-linking agent, and a monomer. The hydrogel material provided by the present invention has high adhesion, and can thus firmly bond to the surface of a substrate, and can also increase the lubricity and antifouling performance of the substrate.

Description

A hydrogel material and a preparation method and application thereof TECHNICAL FIELD

[0001] The present application belongs to the technical field of hydrogel materials, and particularly relates to a hydrogel material and a preparation method and application thereof. BACKGROUND

[0002] The concept of hydrogel was first proposed in 1894, and since then, the development of hydrogel has been extremely rapid, and hydrogel has been widely researched and applied in fields such as drug delivery, tissue engineering, medical implants, wound dressings, contact lenses, sensors, actuators, electronic devices, optical devices, batteries, water collectors and soft robots, etc. At the same time, the controllable modification of hydrogel as a functional coating on the surface of a substrate has become a subject with both prospects and challenges, especially in the electronic and medical fields.

[0003] An ideal hydrogel coating preparation method achieves the following two goals: realizing strong adhesion to the substrate and being able to adhere to the substrate of any shape. Strong adhesion means that the hydrogel coating has strong interaction with the substrate surface, so that the hydrogel coating can be well attached to the substrate and not fall off or break in actual application. The existing hydrogel coating preparation methods on the market, such as surface bridging method, hydrogel coating method, surface initiation method, surface catalytic initiation radical polymerization method, etc., are limited by special monomers, single substrate, fixed substrate shape, complex reaction conditions, etc., and cannot meet the market demand. Therefore, there is an urgent need for new hydrogel coating preparation methods to meet the current market demand.

[0004] SUMMARY

[0005] The present application aims to at least solve one of the technical problems existing in the prior art. To this end, the present application proposes a hydrogel material and a preparation method and application thereof, the hydrogel material having high adhesion, and the hydrogel material coated on the surface of a substrate can improve the lubricity and antifouling effect of the substrate.

[0006] The present application also proposes a preparation method of the above-mentioned hydrogel material.

[0007] The present application also proposes a coating product.

[0008] The present application also proposes an application.

[0009] According to a first aspect of the present application, a hydrogel material is proposed, the hydrogel material comprising the following raw materials: epoxy resin, curing agent, amino acid metal complex, glucose oxidase solution and precursor solution; the precursor solution comprising glucose, crosslinking agent and monomer.

[0010] In some embodiments of the present application, the mass ratio of the epoxy resin, the curing agent, the amino acid metal complex, the precursor solution, and the glucose oxidase solution is (30-70):(30-70):(5-15):(5-15): 1.

[0011] In some preferred embodiments of the present application, the mass ratio of the epoxy resin, the curing agent, the amino acid metal complex, the precursor solution, and the glucose oxidase solution is (40-60):(40-60):(8-12):(8-12): 1.

[0012] In some more preferred embodiments of the present application, the mass ratio of the epoxy resin, the curing agent, the amino acid metal complex, the precursor solution, and the glucose oxidase solution is 50:50:10:10: 1.

[0013] In some preferred embodiments of the present application, the mass ratio of the glucose, the crosslinking agent, and the monomer is (80-120):(0.1-2):(80-200).

[0014] In some more preferred embodiments of the present application, the mass ratio of the glucose, the crosslinking agent, and the monomer is (90-110):(0.2-1.6):(90-200).

[0015] In some more preferred embodiments of the present application, the mass ratio of the glucose, the crosslinking agent, and the monomer is 100:(0.28-1.45):(92.1-198.75).

[0016] In some preferred embodiments of the present application, the concentration of the glucose oxidase in the glucose oxidase solution is 0.05-0.1 wt%.

[0017] In some more preferred embodiments of the present application, the concentration of the glucose oxidase in the glucose oxidase solution is 0.08-0.1 wt%.

[0018] In some embodiments of the present application, the solvent of the glucose oxidase solution comprises a phosphate buffer.

[0019] In some embodiments of the present application, the solvent of the precursor solution comprises a phosphate buffer.

[0020] In some embodiments of the present application, the epoxy resin comprises at least one of E-44, E-51, E-42, E-31, E-21, and E-20.

[0021] In some embodiments of the present application, the curing agent comprises a polyamide curing agent.

[0022] In some embodiments of the present application, the amino acid metal complex comprises at least one of glycine ferrous, histidine ferrous, lysine molybdenum, tryptophan cobalt, cysteine copper, cysteine manganese and tyrosine nickel.

[0023] In some preferred embodiments of the present application, the amino acid metal complex is glycine ferrous.

[0024] In some embodiments of the present application, the cross-linking agent comprises N,N-methyl bisacrylamide or ethylene glycol dimethacrylate.

[0025] In some preferred embodiments of the present application, the cross-linking agent is N,N-methyl bisacrylamide.

[0026] In some embodiments of the present application, the monomer comprises at least one of N-hydroxyethyl acrylamide, N,N-dimethyl acrylamide, acrylic acid, poly(ethylene glycol) methacrylate, acrylamide and sodium alginate.

[0027] According to a second aspect of the present application, there is provided a method for preparing the hydrogel material according to the first aspect of the present application, the method comprising the steps of:

[0028] S1: mixing an amino acid metal complex, an epoxy resin, a glucose oxidase solution and a curing agent to obtain a mixture;

[0029] S2: mixing the mixture of step S1 and a precursor solution to obtain the hydrogel material.

[0030] In some embodiments of the present application, the reaction in step S2 is performed for 10-70 min.

[0031] In some preferred embodiments of the present application, the reaction in step S2 is performed for 15-60 min.

[0032] According to a third aspect of the present application, there is provided a coated product, the coated product comprising a substrate and a hydrogel material according to the first aspect of the present application coated on a surface of the substrate.

[0033] In some embodiments of the present application, the substrate comprises at least one of metal, plastic, ceramic, glass, rubber and wood board.

[0034] In some preferred embodiments of the present application, the metal comprises but is not limited to iron, copper and aluminum.

[0035] In some preferred embodiments of the present application, the plastic comprises but is not limited to acrylic.

[0036] In some preferred embodiments of the present application, the rubber includes but is not limited to silica gel.

[0037] In some embodiments of the present application, the thickness of the hydrogel material coated on the surface of the substrate is 150-600 μm.

[0038] In some embodiments of the present application, the adhesion strength of the hydrogel material coated on the surface of the substrate is 80-700 kPa.

[0039] According to a fourth aspect of the present application, the hydrogel material as described in the first aspect of the present application is used to improve the lubricity and / or antifouling property of a substrate.

[0040] The present application has at least the following beneficial effects:

[0041] 1) The hydrogel material provided by the present application can generate a general-purpose hydrogel coating with high adhesion on the surface of a substrate in situ by fixing ferrous glycinate and glucose oxidase on the surface of a substrate to which epoxy resin is attached, and then reacting with a precursor solution. The present application provides a theoretical basis and technical support for the controllable modification of hydrogel as a functional coating on the surface of a material.

[0042] 2) The hydrogel material provided by the present application uses epoxy resin as a bottom layer. The epoxy resin reacts with other raw materials to form a polymer network through a large number of epoxy groups carried by the epoxy resin. The polymer network then topologically adheres to the surface of the substrate, greatly improving the adhesion of the hydrogel on the surface of the substrate.

[0043] 3) The reaction conditions of the preparation method provided by the present application are mild, nitrogen is not required for the precursor solution, the preparation method is suitable for a variety of substrates of various shapes, and a variety of monomers are suitable for the preparation method.

[0044] 4) The coated product provided by the present application can improve the lubricity and antifouling property of the surface of a substrate by coating the above-mentioned hydrogel material on the surface, and can be widely used in actual production. BRIEF DESCRIPTION OF DRAWINGS

[0045] The present application will be further described below in conjunction with the drawings and examples, in which:

[0046] FIG. 1 is an SEM result graph of the cross section of the hydrogel coating of the coated product in the test example of the present application, wherein the scale is 10 μm;

[0047] FIG. 2 is a detection result graph of the thickness of the hydrogel coating of the coated product prepared for different substrates in the test example of the present application;

[0048] FIG. 3 is a detection result graph of the thickness of the hydrogel coating of the coated product prepared for different polymer monomers in the test example of the present application;

[0049] Figure 4 is a FTIR result diagram of the coating product prepared by different polymerization monomers in the test example of the present application; wherein, Figure A is the FTIR spectrum of the hydrogel coating layer, PEGMA monomer and AA monomer prepared by AA+PEGMA, Figure B is the FTIR spectrum of the hydrogel coating layer, HEAA monomer and SA monomer prepared by HEAA+SA;

[0050] Figure 5 is a result diagram of the adhesion strength test of the hydrogel coating layer of the coating product prepared by different polymerization monomers in the test example of the present application; wherein, Figure A is the adhesion test curve, and Figure B is the adhesion strength calculated according to the curve in Figure A;

[0051] Figure 6 is a result diagram of the lubrication performance test of the hydrogel coating layer in the test example of the present application;

[0052] Figure 7 is a result diagram of the anti-biofouling test of the hydrogel coating layer in the test example of the present application. DETAILED DESCRIPTION

[0053] The concept and technical effects of the present application will be described below in combination with the embodiments, so as to fully understand the purpose, features and effects of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, but not all the embodiments. Based on the embodiments of the present application, other embodiments obtained by those skilled in the art without creative labor are within the protection scope of the present application.

[0054] Embodiment 1

[0055] The present embodiment provides a hydrogel material, and the preparation method of the hydrogel material specifically comprises the following steps:

[0056] 1) The following raw materials are weighed according to the mass fraction: 50 parts of epoxy resin E-44, 50 parts of curing agent 605 (purchased from Miga Zhan, item number 610189137324), 1 part of glucose oxidase (GOD, purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.) solution and 10 parts of ferrous glycinate; the above raw materials are uniformly mixed to obtain a mixed solution; the GOD solution is a PBS buffer solution (0.2M, pH=5) with a concentration of 0.1wt%;

[0057] 2) 92.1 parts by mass of N-hydroxyethyl acrylamide (HEAA), 0.28 parts by mass of N,N-methyl bisacrylamide (MBAA) and 100 parts by mass of glucose are dissolved in 1000 parts by mass of PBS buffer solution to obtain a precursor solution;

[0058] 3) The mixed solution obtained in step 1) and the precursor solution obtained in step 2) are uniformly mixed, and reacted for 15min to obtain a PHEAA hydrogel material.

[0059] Embodiment 2

[0060] This embodiment provides a hydrogel material, the preparation method of which is the same as that of Example 1, except that 92.1 parts by mass of HEAA in step 2) is replaced by 106.6 parts by mass of acrylamide (AM) and the amount of MBAA is adjusted to 0.32 parts by mass, to prepare a PAM hydrogel material.

[0061] Example 3

[0062] This embodiment provides a hydrogel material, the preparation method of which is the same as that of Example 1, except that 92.1 parts by mass of HEAA in step 2) is replaced by 149.7 parts by mass of N,N-dimethylacrylamide (DMAA) and the amount of MBAA is adjusted to 0.74 parts by mass, to prepare a PDMAA hydrogel material.

[0063] Example 4

[0064] This embodiment provides a hydrogel material, the preparation method of which is the same as that of Example 1, except that 92.1 parts by mass of HEAA in step 2) is replaced by 33.15 parts by mass of acrylic acid (AA) and 165.6 parts by mass of poly(ethylene glycol) methacrylate (PEGMA) and the amount of MBAA is adjusted to 0.99 parts by mass, to prepare a PAA-PEGMA hydrogel material.

[0065] Example 5

[0066] This embodiment provides a hydrogel material, the preparation method of which is the same as that of Example 1, except that 92.1 parts by mass of HEAA in step 2) is replaced by 115.13 parts by mass of HEAA and 30 parts by mass of sodium alginate (SA) and the amount of MBAA is adjusted to 1.45 parts by mass, and the reaction time of step 3) is adjusted to 60 min, to prepare a PHEAA-SA hydrogel material.

[0067] Example 6

[0068] This embodiment provides a coated product, which is composed of an acrylic substrate (25 mm x 50 mm) and the hydrogel material provided by Example 1, and the specific preparation method of the coated product comprises the following steps:

[0069] 1) The following raw materials are weighed according to parts by mass: 50 parts of epoxy resin E-44, 50 parts of curing agent 605 (purchased from Miga Zhan, product number 610189137324) and 10 parts of ferrous glycinate; the above raw materials are mixed uniformly, the mixture is uniformly coated on the acrylic substrate, and placed in a 70°C oven for drying for 30 min to obtain a pretreated substrate;

[0070] 2) 1 part by mass of glucose oxidase (GOD) was dissolved in 1000 parts by mass of PBS buffer (0.2M, pH=5) to obtain a GOD solution; 1 part by mass of the GOD solution was dropped on the pretreated substrate obtained in step 1), and was allowed to stand for 1 hour, and then the substrate surface was rinsed with PBS to obtain a substrate covered with GOD;

[0071] 3) 92.1 parts by mass of N-hydroxyethyl acrylamide (HEAA), 0.28 parts by mass of N,N-methyl bisacrylamide (MBAA), and 100 parts by mass of glucose were dissolved in 1000 parts by mass of PBS buffer to obtain a precursor solution;

[0072] 4) 10 parts by mass of the precursor solution obtained in step 3) was taken, and the substrate covered with GOD obtained in step 2) was put into the precursor solution to react for 15 minutes to obtain a coated product coated with the high-attachment general-purpose hydrogel material.

[0073] Example 7

[0074] This example provides a coated product composed of a silica gel substrate and the hydrogel material provided in Example 1, and the preparation method is the same as that of Example 6, except that the acrylic substrate is replaced by a silica gel substrate.

[0075] Example 8

[0076] This example provides a coated product composed of a glass substrate and the hydrogel material provided in Example 1, and the preparation method is the same as that of Example 6, except that the acrylic substrate is replaced by a glass substrate.

[0077] Example 9

[0078] This example provides a coated product composed of an iron substrate and the hydrogel material provided in Example 1, and the preparation method is the same as that of Example 6, except that the acrylic substrate is replaced by an iron substrate.

[0079] Example 10

[0080] This example provides a coated product composed of a copper substrate and the hydrogel material provided in Example 1, and the preparation method is the same as that of Example 6, except that the acrylic substrate is replaced by a copper substrate.

[0081] Example 11

[0082] This example provides a coated product composed of an aluminum substrate and the hydrogel material provided in Example 1, and the preparation method is the same as that of Example 6, except that the acrylic substrate is replaced by an aluminum substrate.

[0083] Example 12

[0084] This example provides a coated product consisting of a PVC substrate and the hydrogel material provided in Example 1, prepared in the same way as Example 6.

[0085] Example 13

[0086] This example provides a coated product consisting of a PVC substrate and the hydrogel material provided in Example 3, prepared in the same way as Example 6.

[0087] Example 14

[0088] This example provides a coated product consisting of a PVC substrate and the hydrogel material provided in Example 4, prepared in the same way as Example 6.

[0089] Example 15

[0090] This example provides a coated product consisting of a PVC substrate and the hydrogel material provided in Example 5, prepared in the same way as Example 6.

[0091] Example 16

[0092] This example provides a coated product consisting of a PVC substrate of 50 mm x 20 mm x 1 mm and the hydrogel material provided in Example 1, prepared in the same way as Example 6; the only difference being that the acrylic substrate is replaced by a PVC substrate and the reaction time in step 4) is 45 min.

[0093] Example 17

[0094] This example provides a coated product consisting of a PVC substrate of 50 mm x 20 mm x 1 mm and the hydrogel material provided in Example 2, prepared in the same way as Example 12; the only difference being that the acrylic substrate is replaced by a PVC substrate and the reaction time in step 4) is 45 min.

[0095] Example 18

[0096] This example provides a coated product consisting of a PVC substrate of 50 mm x 20 mm x 1 mm and the hydrogel material provided in Example 3, prepared in the same way as Example 13; the only difference being that the acrylic substrate is replaced by a PVC substrate and the reaction time in step 4) is 45 min.

[0097] Example 19

[0098] This example provides a coated product, which is composed of a PVC substrate of 50mm x 20mm x 1mm and the hydrogel material provided by Example 4, and the preparation method is the same as that of Example 14; the only difference is that the acrylic substrate is replaced by a PVC substrate, and the reaction time of step 4) is 45min.

[0099] Example 20

[0100] This example provides a coated product, which is composed of a PVC substrate of 50mm x 20mm x 1mm and the hydrogel material provided by Example 5, and the preparation method is the same as that of Example 15; the only difference is that the acrylic substrate is replaced by a PVC substrate.

[0101] Example 21

[0102] This example provides a coated product, which is composed of a glass substrate and the hydrogel material provided by Example 4, and the preparation method is the same as that of Example 14, and the only difference is that the acrylic substrate is replaced by a glass substrate.

[0103] Test Example

[0104] This test example tests a number of characterization parameters of the hydrogel material in the coated products prepared in Examples 6-20, including the microstructure characterized by scanning electron microscopy (SEM), the thickness of the hydrogel material on different substrate surfaces, the thickness of the hydrogel material with different raw material ratios, Fourier infrared spectroscopy (FTIR) characterization, and adhesion strength. The specific test methods and test results are as follows:

[0105] 1. Characterization of coated products by SEM:

[0106] The coated product prepared in Example 6 was frozen by liquid nitrogen and broken, dried for 12h by a vacuum freeze dryer, and the cross-section of the hydrogel coating was observed and photographed by SEM, and the results are shown in Figure 1.

[0107] As can be seen from Figure 1, the hydrogel coating is tightly combined with the substrate, and part of the hydrogel extends into the epoxy / glycine ferrous / glucose oxidase layer, and the surface hydrogel coating is firmly attached to the substrate by combining with the epoxy / glycine ferrous / glucose oxidase layer.

[0108] 2. Detection of the thickness of the hydrogel coating of the coated products prepared by different substrates:

[0109] The thickness of the hydrogel on the surface of the coated products prepared in Examples 6-11 was detected by polarized light microscopy, and the results are shown in Figure 2; the substrates used in the coated products prepared in Examples 6-11 are shown in Table 1.

[0110] Table 1 Substrates used in the coated products prepared in Examples 6-11

[0111] As shown in FIG. 2, the thickness of the hydrogel coating layer obtained by coating the hydrogel material provided in Example 1 of the present application on the surface of different kinds of substrates is relatively stable, and is basically maintained at 400-500 μm, indicating that the hydrogel material provided in the present application can be successfully coated on the surface of various substrates, and is suitable for wide application in actual production.

[0112] 3. The thickness of the hydrogel coating layer of the coating product prepared by different polymerized monomers was detected.

[0113] The thickness of the hydrogel on the surface of the coating product prepared in Example 6 and Examples 12-15 was detected by using a polarizing microscope, and the obtained results are shown in FIG. 3; the formula of the precursor solution used in the coating product prepared in Example 6 and Examples 12-15 is shown in Table 2.

[0114] Table 2 Formula of the precursor solution used in the coating product obtained in Example 6 and Examples 12-15

[0115] As shown in FIG. 3, the hydrogel coating layer can be successfully prepared by using the above monomers, and the thickness of the coating layer slightly differs with the structure of the monomers.

[0116] 4. The coating product was characterized by using FTIR.

[0117] Fourier transform infrared spectroscopy (Nicolet iS50, Thermo Fisher Scientific, USA) was used to analyze the chemical structure of the freeze-dried epoxy / glycine ferrous / glucose oxidase layer and the hydrogel coating layer in the wavelength range of 400-4000 cm -1 .

[0118] As shown in FIG. 4, the FTIR spectrum shows that 1250 cm -1 is the in-plane bending of C-O stretching and O-H coupling on PAA, 1110 cm -1 is the C-O stretching peak of PEGMA, 1542 cm -1 is the N-H bending vibration (amide II) of HEAA, and 1050 cm -1 is the C-O-C stretching of SA, and the above results confirm that the coating product coated with the hydrogel layer is successfully prepared by using the polymerized monomers AA+PEGMA and HEAA+SA in the present application.

[0119] 5. The adhesion of the hydrogel coating layer of the coating product prepared by different polymerized monomers was detected.

[0120] The coated products prepared in Examples 16-20 were subjected to aging treatment at room temperature for 3h, and then the adhesive strength of the gel coating was tested by using an electronic universal testing machine to perform a lap shear test, pulling the hydrogel coating at a speed of 5mm / min until failure, and calculating the adhesive strength by dividing the maximum strength by the adhesive area; the formulations of the precursor solutions used for the coated products prepared in Examples 16-20 are shown in Table 3; and the results are shown in Figure 5.

[0121] Table 3 Formulations of precursor solutions used for the coated products prepared in Examples 16-20

[0122] As can be seen from Figure 5, the hydrogel coatings prepared using different polymerization monomers have different adhesion strengths, and the adhesive strength of the PDMAA hydrogel coating reaches 686kPa, indicating that the high-adhesion general-purpose hydrogel material prepared using the present application has higher adhesion strength.

[0123] 6. Testing the lubricating ability of the hydrogel coating:

[0124] The coated product prepared in Example 12 was used as the test group, and an acrylic substrate was used as the control group, the test group and the control group were placed horizontally on the experimental table, and formed a 5° inclination angle with the laboratory, then a 50g weight was placed at one end of the two groups, and the results are shown in Figure 6.

[0125] As can be seen from Figure 6, the weight on the test group coated with the coating will slide off, while the weight on the control group remains stationary. The above results show that the hydrogel material provided by the present application has excellent lubricating properties, and coating the hydrogel material on the substrate can reduce the friction on the surface of the substrate.

[0126] 7. Testing the anti-biological contamination performance of the hydrogel coating:

[0127] Bovine protein serum was used as the biological contaminant, and the coated products prepared in Examples 8 and 21 were used as the test group, and a glass substrate was used as the control group to perform an anti-biological contamination test; the anti-biological contamination test specifically includes the following steps:

[0128] 1) 100μL of bovine serum albumin (BSA-Cy5.5) labeled with sulfo-cyanine 5.5 dye was applied to a glass slide, and was applied to the hydrogel coatings (size: 25mm x 50mm) prepared in Examples 8 and 21, respectively;

[0129] 2) After standing for 4h, the samples were rinsed and washed with deionized water at least three times to remove unattached BSA on the surface;

[0130] 3) The coating surface was observed using a laser confocal microscope, and the percentage of the coating surface occupied by the protein was automatically identified using image J, which was further used to evaluate the anti-biofouling performance of the hydrogel coating, and the results are shown in Figure 7.

[0131] As can be seen from Figure 7, the hydrogel material prepared in the application has excellent anti-biofouling ability, and coating the hydrogel material on the surface of the substrate can significantly reduce the adsorption of proteins on the coating surface, thereby improving the anti-biofouling ability of the coated product, and the hydrogel material provided by the application is suitable for being widely applied in bacteriostatic or antibacterial materials.

[0132] The embodiments of the application are described in detail above with reference to the drawings, but the application is not limited to the above-described embodiments, and various changes can be made within the knowledge of those skilled in the art without departing from the purpose of the application. In addition, the embodiments of the application and the features in the embodiments can be combined with each other without conflict.

Claims

1. A hydrogel material, characterized in that, The hydrogel material comprises raw materials of an epoxy resin, a curing agent, an amino acid metal complex, a glucose oxidase solution and a precursor solution. The precursor solution comprises glucose, a crosslinking agent and a monomer.

2. The hydrogel material of claim 1, wherein, The mass ratio of the epoxy resin, the curing agent, the amino acid metal complex, the precursor solution and the glucose oxidase solution is (30-70):(30-70):(5-15):(5-15):

1. Preferably, the mass ratio of the glucose, the crosslinking agent and the monomer is (80-120):(0.1-2):(80-200). Preferably, the concentration of glucose oxidase in the glucose oxidase solution is 0.05-0.1wt%.

3. The hydrogel material of claim 1, wherein, The epoxy resin comprises at least one of E-44, E-51, E-42, E-31, E-21 and E-20.

4. The hydrogel material of claim 1, wherein, The curing agent comprises a polyamide curing agent.

5. The hydrogel material of claim 1, wherein, The amino acid metal complex comprises at least one of glycine ferrous, histidine ferrous, lysine molybdenum, tryptophan cobalt, cysteine copper, cysteine manganese and tyrosine nickel.

6. The hydrogel material of claim 1, wherein, The crosslinking agent comprises N,N-methyl bisacrylamide or dimethyl glycol acrylate.

7. The hydrogel material of claim 1, wherein, The monomer comprises at least one of N-hydroxyethyl acrylamide, N,N-dimethyl acrylamide, acrylic acid, poly(ethylene glycol) methacrylate, acrylamide and sodium alginate.

8. A method for the preparation of a hydrogel material as claimed in any one of claims 1 to 7, characterized in that The preparation method comprises the following steps: S1: mixing the amino acid metal complex, the epoxy resin, the glucose oxidase solution and the curing agent to obtain a mixed solution; S2: mixing the mixed solution of step S1 and the precursor solution to obtain the hydrogel material.

9. A coated product characterized by, The coated product comprises a substrate and the hydrogel material coated on the surface of the substrate.

10. Application of the hydrogel material as claimed in any one of claims 1-7 to improve the lubricity and / or antifouling property of a substrate.

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