Substituted arylpyrazines and salts thereof, and use thereof as herbicides

Abstract

The present invention relates to substituted arylprazines and salts thereof according to formula (I), to methods for the production thereof, and to the use thereof as herbicides, in particular for controlling weeds and / or weed grasses in crops of useful plants and / or as plant growth regulators for influencing the growth of crops of useful plants.

Description

[0001]BCS241005-Abroad STR 1 Bayer AG Substituted Arylpyrazines and their Salts and their Use as Herbicidal Active Ingredients 5 Description The invention relates to the technical field of plant protection products, in particular herbicides for the selective control of weeds and grasses in crops. 10 Specifically, this invention relates to substituted arylpyrazines and their salts, processes for their production, and their use as herbicides, in particular for controlling weeds and / or grasses in crops and / or as plant growth regulators to influence the growth of crops.15 Previously known plant protection products for the selective control of weeds in crops or active ingredients for controlling unwanted plant growth have some disadvantages in their application, be it that (a) they have no or insufficient herbicidal activity against certain weeds, (b) too narrow a spectrum of weeds that can be controlled with one active ingredient, (c) too low selectivity in crops 20 and / or (d) an unfavorable toxicological profile. Furthermore, some active ingredients that can be used as plant growth regulators in some crops lead to undesirably reduced yields in other crops or are not compatible with the crop or only within a narrow application rate range.Some of the known active ingredients cannot be produced economically on an industrial scale due to the difficulty in obtaining precursors and reagents, or they possess insufficient chemical stability. For other active ingredients, the efficacy depends too heavily on environmental conditions, such as weather and soil conditions. The herbicidal activity of these known compounds, particularly at low application rates, and their compatibility with crops remain in need of improvement. It is known from various publications that certain substituted heteroaryltriazoles and heteroaryltetrazoles can be used as active ingredients against ectoparasites in animals or against insects to prevent feeding damage in crops (see WO2017 / 192385, WO 2019 / 170626 and WO 2019 / 215198). Further heteroaryltriazoles and heteroaryltetrazoles, as well as their insecticidal activity when applied to crops, have also been described (seeWO 2019 / 201835, 35 WO 2019 / 197468, WO 2019 / 202077, WO 2019 / 206799, WO 2023 / 037249). BCS241005-Abroad STR 2 It is also known that certain azolamides can be used as insecticidal active substances (WO2020 / 002563, WO2020 / 053364, WO2020 / 053365, WO2020 / 079198). It is also known that substituted heteroaryloxazoles and heteroarylthiazoles also exhibit insecticidal effects (see WO2023 / 110473). 5 It is also known that substituted heteroarylpyrazines can be used as insecticidal active substances (see WO2020 / 201079; WO2020 / 208036, WO2020 / 201398, WO2021 / 069575, WO2021 / 068179, WO2022 / 258481). Substituted N-(arylpyrazinylalkyl)carboxamides with herbicidal activity, however, have not yet been described. Substituted arylquinoxalines and their use as PI3 kinase inhibitors (see WO2020 / 201079; WO2020 / 208036, WO2020 / 201398, WO2021 / 069575, WO2021 / 068179, WO2022 / 258481) are also known.While substituted N-(arylpyrazinylalkyl)carboxamides with substituted pyrazinylbenzoic acid groups have been described in WO2016 / 054491, they have not yet been described. Surprisingly, it has now been found that certain substituted arylpyrazines or their salts 15 are well suited as herbicides and can be used particularly advantageously as active ingredients for controlling monocotyledonous and dicotyledonous weeds in crops. The present invention thus relates to substituted arylpyrazines of general formula (I) or their salts. 20 wherein M for one of the groups M -1 M-2 M-3 25, where the dashed line indicates the link to the rest of formula (I), BCS241005-Abroad STR 3 R 1R stands for aryl or heteroaryl, wherein the aryl or heteroaryl group is optionally further substituted by 1, 2 or 3 independently chosen substituents bonded to ring carbon atoms 4 , and where, if necessary, two adjacent substituents R 4 with the ring carbon atoms to which they are bonded, can form a saturated, partially saturated or unsaturated 5- to 7-membered ring, optionally interrupted by heteroatoms and optionally further substituted, 10 or R 1represents a five- or six-membered heterocyclyl, which may be saturated or partially saturated, which may contain one to four heteroatoms and which bears n oxo groups, wherein each heteroatom is independently chosen from a group consisting of oxygen, nitrogen, and sulfur, and wherein the heterocyclyl residue is optionally substituted 15 by one, two, or three substituents, which are independently chosen from a group consisting of (C1-C6)-alkyl, (C1-C6)-haloalkyl, (C1-C6)-cycloalkyl, (C1-C6)-alkoxy, (C1-C6)-alkoxy-(C1-C6)-alkyl, (C2-C6)-alkenyl, (C1-C6)-haloalkoxy, halogen, aryl, heteroaryl, (heterocyclyl)aryl, 20 R 2 for hydrogen, (C1-C8)-alkyl, (C3-C8)-cycloalkyl, (C1-C8)-cyanoalkyl, (C3-C8)-cycloalkyl- (C1-C8)-alkyl, (C2-C8)-alkenyl, (C2-C8)-haloalkenyl, (C2-C8)-alkynyl, (C2-C8)-haloalkynyl, NR 11 R 12 , S(O)R 14 , SO2R 14 , C(O)OR 13 , C(O)R 13or for aryl-(C1-C8)-alkyl, wherein the aryl group optionally carries a further 1 to 5 substituents, which can be independently substituted for halogen, cyano, nitro, trimethylsilyl, pentafluorosulfanyl, -C(=S)NH2, OR 13 , NR 11 R 12 , SR 14 ,25 S(O)R 14 , SO2R 14 , C(O)OR 13 , C(O)R 13 , (C1-C8)-alkyl, (C3-C8)-cycloalkyl, (C3-C8)-cycloalkyl- (C1-C8)-alkyl, (C2-C8)-alkenyl, (C2-C8)-haloalkenyl, (C2-C8)-alkynyl, (C2-C8)-haloalkynyl, (C3- C8)-cycanocycloalkyl, (C3-C6)-halocycloalkyl, (C1-C8)-haloalkyl, (C1-C8)-cyanoalkyl, or heteroaryl-(C1-C8)-alkyl, heterocyclyl-(C1-C8)-alkyl and where heterocyclyl carries n oxo groups, 30 R 3 for (C1-C8)-alkyl, (C3-C8)-cycloalkyl, (C2-C8)-alkenyl, R 13 O-(C1-C8)-alkyl, (C3-C8)-cycloalkyl-(C1-C8)-alkyl, R 4 for Halogen, Cyano, Thiocyanato, Isothiocyanato, Pentafluorosulfanyl, Nitro, Aryldiazo, 35 NR 11 R 12 , OR 13 , SR14 , S(O)R 14 , SO2R 14 , S(O)(=N-R 11 )R 14 , S(O)(=N-R 11 )OR 13 , OSO2-Aryl, OSO2- (C1-C8)-alkyl, OSO2-(C1-C8)-haloalkyl, OSO2-(C3-C8)-cycloalkyl, C(O)OR 13 , C(O)R 13 , C(O)NR 11 R 12 , C(S)NR 11 R 12 , -C=NOR 13 , R 13 OOC-(C1-C8)-alkyl, R 13 O-(C1-C8)-alkyl, R 14 S-(C1- BCS241005-Ausland STR 4 C8)-alkyl, R 13 (O)C-(C1-C8)-alkyl, (C1-C8)-Alkyl, Cyano-(C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2- C8)-Alkinyl, (C1-C 10 )-Haloalkyl, (C2-C8)-Haloalkenyl, (C2-C8)-Haloalkinyl, (C3-C 10 )-Cycloalkyl, (C4-C 10 )-Cycloalkenyl, (C4-C 10 )-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)-haloalkyl, (C1-C8)- Haloalkoxy-(C1-C8)-haloalkyl, Aryl, Aryl-(C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1-C8)-alkyl, 5 (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-haloalkyl, (C4-C 10)-Cycloalkenyl-(C1-C8)-alkyl, (C4-C 10 )-Cycloalkenyl-(C1-C8)-haloalkyl, heterocyclyl, heterocyclyl-(C1-C8)-alkyl, aryl-(C1-C8)-alkynyl, heteroaryl-(C1-C8)-alkynyl, heterocyclyl-(C1-C8)-alkynyl, tris-[(C1- C8)-alkyl]silyl-(C2-C8)-alkynyl, bis-[(C1-C8)-alkyl](aryl)silyl-(C2-C8)-alkynyl, bis-aryl[(C1-C8)-alkyl]silyl-(C2-C8)-alkynyl, (C3-C8)-cycloalkyl-(C2-C8)-alkynyl, Aryl-(C2-C8)-alkenyl, 10 Heteroaryl-(C2-C8)-alkenyl, Heterocyclyl-(C2-C8)-alkenyl, (C3-C8)-cycloalkyl-(C2-C8)-alkenyl, cyano-(C3-C8)-cycloalkylaminosulfonylamino, tris-[(C1-C8)-alkyl]silyl, bis-[(C1-C8)-alkyl](aryl)silyl, bis-aryl[(C1-C8)-alkyl]silyl, wherein heterocyclyl carries n oxo groups and wherein cycloalkyl may be substituted by one or more substituents selected from a group consisting of (C1-C8)-alkyl, (C1-C8)-haloalkyl, halogen, cyano, carbamoyl and 15 (C1-C8)-alkylsulfonyl and wherein aryl or heteroaryl groups may be substituted by one or two alkoxycarbonyl groups, R5 , R 6 independently for hydrogen, halogen, cyano, (C1-C8)-alkyl, (C1-C8)-haloalkyl, (C3-C8)-cycloalkyl, (C3-C8)-halocycloalkyl, (C2-C8)-alkenyl, (C2-C8)-alkynyl, R 13 O-(C1-C8)-20 alkyl, (C3-C8)-cycloalkyl-(C1-C8)-alkyl, OR 13 , NR 11 R 12 , SR 14 , S(O)R 14 , SO2R 14 , -C=NOR 13 stand, R 7 for hydrogen, halogen, (C1-C8)-alkyl, (C3-C8)-cycloalkyl, (C1-C8)-alkoxy, (C1-C8)-haloalkoxy, (C1-C8)-haloalkyl, 25 Q for hydroxy or a residue of the following formulas Q -1 Q-2 steht, R 8 for hydrogen, (C1-C8)-alkyl, (C1-C8)-haloalkyl, aryl, aryl-(C1-C8)-alkyl, heteroaryl, 30 (C2-C8)-alkynyl, (C2-C8)-alkenyl, C(O)R 13 , C(O)OR 13 , (C1-C8)-alkoxy-(C1-C8)-alkyl, R 9 BCS241005-Ausland STR 5 R stands for hydrogen or (C1-C8) alkyl 10für Wasserstoff, Halogen, Cyano, NO2, (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, (C3-C8)-Cycloalkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C3-C8)-Halocycloalkyl, (C3-C8)-Halocycloalkyl-(C1-C8)- alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, Aryl, Aryl-(C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1- C8)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-alkyl, R 11 R 12 N-(C1-C8)-alkyl, R 13 O-(C1-C8)-alkyl, 5 Cyano-(C1-C8)-alkyl, (C1-C8)-Alkylcarbonyloxy-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl- carbonyloxy-(C1-C8)-alkyl, Arylcarbonyloxy-(C1-C8)-alkyl, Heteroarylcarbonyloxy-(C1-C8)- alkyl, Heterocyclylcarbonyloxy-(C1-C8)-alkyl, OR 13 , NR 11 R 12 , SR 14 , S(O)R 14 , SO2R 14 , R 14 S-(C1- C8)-alkyl, R 14 (O)S-(C1-C8)-alkyl, R 14O2S-(C1-C8)-alkyl, tris-[(C1-C8)-alkyl]silyl-(C1-C8)-alkyl, bis-[(C1-C8)-alkyl](aryl)silyl(C1-C8)-alkyl, [(C1-C8)-alkyl]-bis-(aryl)silyl-(C1-C8)-alkyl, Tris-10[(C1-C8)-alkyl]silyl, bis-hydroxyboryl-(C1-C8)-alkyl, bis-[(C1-C8)-alkoxy]boryl-(C1-C8)-alkyl, tetramethyl-1,3,2-dioxaborolan-2-yl, Tetramethyl-1,3,2-dioxaborolan-2-yl-(C1-C8)-alkyl, nitro-(C1-C8)-alkyl, C(O)OR 13 , C(O)R 13 , C(O)NR 11 R 12 , R 13 O(O)C-(C1C8)-alkyl, R 11 R 12 N(O)C- (C1-C8)-alkyl, bis-(C1-C8)-alkoxy-(C1-C8)-alkyl, where heterocyclyl carries n oxo groups, or 15 R 8 and R 10 with the carbon atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted, 3 to 10-membered monocyclic or bicyclic ring, 20 R 11 and R 12gleich oder verschieden sind und unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C 10 )-Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkinyl, (C3-C 10 )-Cycloalkyl, (C3-C 10 )-Halocycloalkyl, (C4-C 10 )-Cycloalkenyl, (C4- C 10 )-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)-alkyl, (C1-C8)-Haloalkoxy-(C1-C8)-alkyl, (C1- C8)-Alkylthio-(C1-C8)-alkyl, (C1-C8)-Haloalkylthio-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-25 haloalkyl, Aryl, Aryl-(C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl- (C1-C8)-alkyl, (C4-C 10 )-Cycloalkenyl-(C1-C8)-alkyl, COR 13 , SO2R 14, heterocyclyl, (C1-C8)-alkoxycarbonyl, bis-[(C1-C8)-alkyl]aminocarbonyl-(C1-C8)-alkyl, (C1-C8)-alkyl-amino-carbonyl-(C1-C8)-alkyl, aryl-(C1-C8)-alkyl-aminocarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxycarbonyl, heteroaryl-(C1-C8)-alkoxycarbonyl, (C2-C8)-alkenyloxycarbonyl, (C2-C8)-30 alkynyloxycarbonyl, heterocyclyl-(C1-C8)-alkyl, where heterocyclyl carries n oxo groups, or R 11 and R 12 with the nitrogen atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by further heteroatoms and optionally further substituted 35 times, monocyclic or bicyclic ring with 3 to 10 members, BCS241005-Ausland STR 6 R 13 for hydrogen, (C1-C8)-alkyl, (C2-C8)-alkenyl, (C2-C8)-alkynyl, (C1-C8)-cyanoalkyl, (C1-C 10 )- Haloalkyl, (C2-C8)-haloalkenyl, (C3-C8)-haloalkynyl, (C3-C 10 )-Cycloalkyl, (C4-C 10 )- Cycloalkenyl, (C4-C 10)-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)-alkyl, (C1-C8)-Haloalkoxy- (C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-haloalkyl, (C1-C8)-Alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, 5 (C1-C8)-Alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-alkoxy- (C1-C8)-alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, Aryl, Aryl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxy- (C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C4-C 10 )- Cycloalkenyl-(C1-C8)-alkyl, Bis-[(C1-C8)-alkyl]aminocarbonyl-(C1-C8)-alkyl, (C1-C8)-Alkyl- aminocarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkyl-aminocarbonyl-(C1-C8)-alkyl, Bis-[(C1-C8)-10 alkyl]amino-(C2-C6)-alkyl, (C1-C8)-Alkyl-amino-(C2C6)-alkyl, Aryl-(C1-C8)-alkylamino-(C2-C6)- alkyl, R 14 S-(C1-C8)-alkyl, R 14 (O)S-(C1-C8)-alkyl, R 14O2S-(C1-C8)-alkyl, Hydroxycarbonyl-(C1- C8)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-alkyl, Tris-[(C1-C8)-Alkyl]silyl-(C1-C8)-alkyl, Bis-[(C1-C8)-Alkyl](aryl)silyl(C1-C8)-alkyl, [(C1-C8)-Alkyl]-bis-(aryl)silyl-(C1-C8)-alkyl, (C1- C8)-Alkylcarbonyloxy-(C1-C8)-alkyl, (C3-C8)-Cycloalkylcarbonyloxy-(C1-C8)-alkyl, 15 Arylcarbonyloxy-(C1-C8)-alkyl, Heteroarylcarbonyloxy-(C1-C8)-alkyl, Heterocyclylcarbonyloxy-(C1-C8)-alkyl, Aryloxy-(C1-C8)-alkyl, Heteroaryloxy-(C1-C8)-alkyl, (C1-C8)-Alkoxycarbonyl steht, wobei Heterocyclyl n Oxogruppen trägt und wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl und (C1-C8)- 20 Alkylsulfonyl, R 14 für (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C 10 )-Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkinyl, (C3-C 10 )-Cycloalkyl, (C4-C 10 )-Cycloalkenyl, (C4-C 10)- Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-haloalkyl, Aryl, Aryl-25 (C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1-C8)-alkyl, Heterocyclyl-(C1-C8)-alkyl, (C3-C8)- Cycloalkyl-(C1-C8)-alkyl, (C4-C 10)-Cycloalkenyl-(C1-C8)-alkyl, amino, bis-[(C1-C8)-alkyl]amino, (C1-C8)-alkyl-amino, aryl-(C1-C8)-amino, aryl-(C1-C6)-alkyl-amino, aryl-[(C1-C8)-alkyl]amino, (C3-C8)-cycloalkyl-amino, (C3-C8)-cycloalkyl-[(C1-C8)-alkyl]amino, N-azetidinyl, N-pyrrolidinyl, N-piperidinyl, N-morpholinyl, 30 where the last twelve radicals (ie amino, bis-[(C1-C8)-alkyl]amino, (C1-C8)-alkyl-amino, aryl-(C1-C8)-amino, aryl-(C1-C6)-alkyl-amino, Aryl-[(C1-C8)-alkyl]amino, (C3-C8)-cycloalkyl-amino, (C3-C8)-cycloalkyl-[(C1-C8)-alkyl]amino, N-acetidinyl, N-pyrrolidinyl, N-piperidinyl, N-morpholinyl) are bonded only to sulfonyl groups, and wherein heterocyclyl carries n oxo groups, 35 and wherein cycloalkyl may be substituted by one or more substituents selected from a group consisting of (C1-C8)-alkyl, (C1-C8)-haloalkyl, halogen, cyano, carbamoyl and (C1-C8)-alkylsulfonyl, BCS241005-Ausland STR 7 R 15 and R 16independently of each other stand for (C1-C8)-alkyl, (C3-C8)-cycloalkyl, aryl, heteroaryl, heterocyclyl, where heterocyclyl carries n oxo groups, or 5 R 15 and R 16 with the carbon atom to which they are bonded, they form a fully saturated monocyclic carbocycle of 3 to 7 members, R 17 , R 18 , R 19 and R 20The numbers 10 and n represent hydrogen, halogen, (C1-C8)-alkyl, (C1-C8)-alkoxy, (C1-C8)-haloalkoxy, (C3-C8)-cycloalkyl, and (C1-C8)-haloalkyl, respectively, and n represents 0, 1, or 2, respectively. The compounds of general formula (I) can form salts by the addition of a suitable inorganic or organic acid, such as mineral acids (e.g., HCl, HBr, H2SO4, H3PO4, or HNO3), or organic acids (e.g., carboxylic acids such as formic acid, acetic acid, propionic acid, oxalic acid, lactic acid, or salicylic acid), or sulfonic acids (e.g., p-toluenesulfonic acid), to a basic group (e.g., amino, alkylamino, dialkylamino, piperidino, morpholino, or pyridino). These salts then contain the conjugate base of the acid as an anion. Suitable substituents, which exist in deprotonated form, such as sulfonic acids, certain sulfonamides, or carboxylic acids, can form inner salts with their own protonatable groups, such as amino groups.Salt formation can also occur through the action of a base on compounds of the general formula (I). Suitable bases include, for example, organic amines such as trialkylamines, morpholine, piperidine, and pyridine, as well as ammonium, alkali, or alkaline earth metal hydroxides, carbonates, and hydrogen carbonates, in particular sodium and potassium hydroxide, sodium and potassium carbonate, and sodium and potassium hydrogen carbonate. These salts are compounds in which the acidic hydrogen is replaced by a cation suitable for agricultural use, for example, metal salts, in particular alkali metal salts or alkaline earth metal salts, in particular sodium and potassium salts, or also ammonium salts, salts with organic amines, or quaternary ammonium salts, for example, with cations of the formula [NR. a R b R c R d ] + , in which R a to R dEach can independently represent an organic residue, in particular alkyl, aryl, aralkyl, or alkylaryl. Alkylsulfonium and alkylsulfoxonium salts, such as (C1-C4)-trialkylsulfonium and (C1-C4)-trialkylsulfoxonium salts, are also possible. 35 The compounds of general formula (I) can exist as stereoisomers depending on the type and combination of the substituents. The possible stereoisomers defined by their specific spatial shape, BCS241005-Ausland STR 8, such as enantiomers, diastereomers, Z- and E-isomers, are all included in formula (I). For example, if one or more alkenyl groups are present, diastereomers (Z- and E-isomers) can occur. If, for example, one or more asymmetrically substituted carbon atoms are present, enantiomers and diastereomers can occur. Stereoisomers can be obtained from the mixtures produced during step 5 of the manufacturing process using standard separation methods.Chromatographic separation can be performed both on an analytical scale to determine the enantiomeric or diastereomeric excess, and on a preparative scale to prepare test samples for biological testing. Likewise, stereoisomers can be selectively prepared by using stereoselective reactions with optically active starting materials and / or excipients. The invention thus also relates to all stereoisomers included in the general formula (I) but not specified with their specific stereoform, as well as their mixtures. Separated enantiomers included in the general formula (I) are either (a) designated with (+)- and (-) according to their optical activity, i.e.,Such isomers, which rotate plane-polarized light clockwise (in the (+) direction), are designated with "(+)" 15; (b) classified into R- and S-enantiomers according to the Cahn-Ingold-Prelog rules, or (c) designated with "Ent-1" and "Ent-2" according to their retention time upon separation by chiral chromatography. Methods for separating enantiomers are well known in the prior art, e.g., separation by chiral chromatography. 20 If the compounds are obtained as solids, purification can also be carried out by recrystallization or digestion. Individual compounds (I) can also be prepared by derivatization of other compounds (I). Methods generally known to those skilled in the art from analogous cases are suitable as isolation, purification, and stereoisomer separation processes for compounds of formula 25 (I), e.g.Any remaining mixtures can generally be separated by physical processes such as crystallization, chromatographic processes, especially column chromatography and HPLC (high-performance liquid chromatography), distillation, optionally under reduced pressure, extraction, and other methods, usually by chromatographic separation, e.g., on chiral solid phases. 30 For preparative quantities or on an industrial scale, processes such as crystallization, e.g., of diastereomeric salts, which can be obtained from the diastereomeric mixtures with optically active acids and, optionally, in the case of present acidic groups, with optically active bases, are suitable. 35 In the following, the compounds of formula (I) and their salts used according to the invention are referred to as "compounds of general formula (I)". BCS241005-Abroad STR 9 The preferred subject matter of the invention is compounds of general formula (I), wherein M represents one of the groups. M -1 M-2 M-35, where the dashed line marks the link to the rest of formula (I), R 1 for aryl or heteroaryl, 10 wherein the aryl or heteroaryl group is optionally further substituted by 1, 2 or 3 substituents bonded to ring carbon atoms and chosen independently of one another R 4 , and where, if necessary, two adjacent substituents R 4 with the ring carbon atoms to which they are bonded, they can form a saturated, partially saturated or 15 unsaturated 5- to 7-membered ring, optionally interrupted by heteroatoms and optionally further substituted, or R 1represents a five- or six-membered heterocyclyl, which may be saturated or partially saturated, which may contain one to four heteroatoms and which bears n oxo groups, 20 wherein each heteroatom is independently chosen from a group consisting of oxygen, nitrogen and sulfur, and wherein the heterocyclyl residue is optionally substituted by one, two or three substituents, which are independently chosen from a group consisting of (C1-C6)-alkyl, (C1-C6)-haloalkyl, (C1-C6)-cycloalkyl, (C1-C6)-alkoxy, (C1-C6)-alkoxy-(C1-C6)-alkyl, (C2-C6)-alkenyl, (C1-C6)-haloalkoxy, halogen, aryl, heteroaryl, 25 (heterocyclyl)aryl; R 2 for hydrogen, (C1-C7)-alkyl, (C3-C7)-cycloalkyl, (C1-C7)-cyanoalkyl, (C3-C7)-cycloalkyl- (C1-C7)-alkyl, (C2-C7)-alkenyl, (C2-C7)-haloalkenyl, (C2-C7)-alkynyl, (C2-C7)-Haloalkynyl, NR 11 R 12 , S(O)R 14 , SO2R 14 , C(O)OR 13 , C(O)R 13or for aryl-(C1-C7)-alkyl, wherein the 30 aryl group optionally carries 1 to 5 further substituents, which can be independently substituted for halogen, cyano, nitro, trimethylsilyl, pentafluorosulfanyl, -C(=S)NH2, OR 13 , NR 11 R 12 , SR 14 , S(O)R 14 , SO2R 14 , C(O)OR 13 , C(O)R 13 , (C1-C7)-alkyl, (C3-C7)-cycloalkyl, (C3-C7)-cycloalkyl- BCS241005-Ausland STR 10 (C1-C7)-alkyl, (C2-C7)-alkenyl, (C2-C7)-haloalkenyl, (C2-C7)-alkynyl, (C2-C7)-haloalkynyl, (C3-C7)-cycanocycloalkyl, (C3-C7)-halocycloalkyl, (C1-C7)-haloalkyl, (C1-C7)-cyanoalkyl, or heteroaryl-(C1-C7)-alkyl, heterocyclyl-(C1-C7)-alkyl and where heterocyclyl n carries oxo groups, 5 R 3 for (C1-C7)-alkyl, (C3-C7)-cycloalkyl, (C2-C7)-alkenyl, R 13 O-(C1-C7)-alkyl, (C3-C7)-cycloalkyl-(C1-C7)-alkyl, R 4 for Halogen, Cyano, Thiocyanato, Isothiocyanato, Pentafluorosulfanyl, Nitro, Aryldiazo, 10 NR 11 R12 , OR 13 , SR 14 , S(O)R 14 , SO2R 14 , S(O)(=N-R 11 )R 14 , S(O)(=N-R 11 )OR 13 , OSO2-Aryl, OSO2- (C1-C7)-alkyl, OSO2-(C1-C7)-haloalkyl, OSO2-(C3-C7)-cycloalkyl, C(O)OR 13 , C(O)R 13 C(O)NR 11 R 12 , C(S)NR 11 R 12 , -C=NOR 13 , R 13 OOC-(C1-C7)-alkyl, R 13 O-(C1-C7)-alkyl, R 13 S-(C1- C7)-alkyl, R 13(O)C-(C1-C7)-alkyl, (C1-C7)-Alkyl, Cyano-(C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2- C7)-Alkinyl, (C1-C7)-Haloalkyl, (C2-C7)-Haloalkenyl, (C2-C7)-Haloalkinyl, (C3-C7)-Cycloalkyl,15 (C4-C7)-Cycloalkenyl, (C4-C7)-Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-haloalkyl, (C1-C7)- Haloalkoxy-(C1-C7)-haloalkyl, Aryl, Aryl-(C1-C7)-alkyl, Heteroaryl, Heteroaryl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-haloalkyl, (C4-C7)-Cycloalkenyl- (C1-C7)-alkyl, (C4-C7)-Cycloalkenyl-(C1-C7)-haloalkyl, Heterocyclyl, Heterocyclyl-(C1-C7)- alkyl, Aryl-(C1-C7)-alkinyl, Heteroaryl-(C1-C7)-alkinyl, Heterocyclyl-(C1-C7)-alkinyl, Tris-[(C1-20 C7)-alkyl]silyl-(C2-C7)-alkinyl, Bis-[(C1-C7)-alkyl](aryl)silyl-(C2-C7)-alkinyl, Bis-aryl[(C1-C7)- alkyl]silyl-(C2-C7)-alkinyl, (C3-C7)-Cycloalkyl-(C2-C7)-alkinyl, Aryl-(C2-C7)-alkenyl, Heteroaryl-(C2-C7)-alkenyl, Heterocyclyl-(C2-C7)-alkenyl, (C3-C7)-Cycloalkyl-(C2-C7)-alkenyl, Cyano-(C3-C7)-Cycloalkylaminosulfonylamino, Tris-[(C1-C7)-alkyl]silyl,Bis-[(C1-C7)-alkyl](aryl)silyl, bis-aryl[(C1-C7)-alkyl]silyl, and wherein heterocyclyl carries n oxo groups, 25 and wherein cycloalkyl may be substituted by one or more substituents selected from a group consisting of (C1-C8)-alkyl, (C1-C8)-haloalkyl, halogen, cyano, carbamoyl and (C1-C8)-alkylsulfonyl, and wherein aryl or heteroaryl groups may be substituted by one or two alkoxycarbonyl groups, 30 R, 5 , R 6 independently for hydrogen, halogen, cyano, (C1-C7)-alkyl, (C1-C7)-haloalkyl, (C3-C7)-cycloalkyl, (C3-C7)-halocycloalkyl, (C2-C7)-alkenyl, (C2-C7)-alkynyl, R 13 O-(C1-C7)-alkyl, (C3-C7)-cycloalkyl-(C1-C7)-alkyl, OR 13 , NR 11 R 12 , SR 14 , S(O)R 14 , SO2R 14 , -C=NOR 13 standing, 35 R 7für Wasserstoff, Halogen, (C1-C7)-Alkyl, (C1-C7)-Alkoxy, (C1-C7)-Haloalkoxy, (C3-C7)- Cycloalkyl, (C1-C7)-Haloalkyl steht, BCS241005-Ausland STR 11 Q für Hydroxy oder einen Rest der nachfolgenden Formeln Q -1 Q-2 steht, R 8 für Wasserstoff, (C1-C7)-Alkyl, (C1-C7)-Haloalkyl, Aryl, Aryl-(C1-C7)-alkyl, Heteroaryl, 5 (C2-C7)-Alkinyl, (C2-C7)-Alkenyl, C(O)R 13 , C(O)OR 13 , (C1-C7)-Alkoxy-(C1-C7)-alkyl steht, R 9 für Wasserstoff oder (C1-C7)-Alkyl steht, R 10 für Wasserstoff, Halogen, Cyano, NO2, (C1-C7)-Alkyl, (C1-C7)-Haloalkyl, (C3-C7)-Cycloalkyl,10 (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, (C3-C7)-Halocycloalkyl, (C3-C7)-Halocycloalkyl-(C1-C7)- alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, Aryl, Aryl-(C1-C7)-alkyl, Heteroaryl, Heteroaryl-(C1- C7)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-alkyl, R 11 R 12 N-(C1-C7)-alkyl, R 13O-(C1-C7)-alkyl, Cyano-(C1-C7)-alkyl, (C1-C7)-Alkylcarbonyloxy-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl- carbonyloxy-(C1-C7)-alkyl, Arylcarbonyloxy-(C1-C7)-alkyl, Heteroarylcarbonyloxy-(C1-C7)-15 alkyl, Heterocyclylcarbonyloxy-(C1-C7)-alkyl, OR 13 , NR 11 R 12 , SR 14 , S(O)R 14 , SO2R 14 , R 14 S-(C1- C7)-alkyl, R 14 (O)S-(C1-C7)-alkyl, R 14 O2S-(C1-C7)-alkyl, Tris-[(C1-C7)-Alkyl]silyl-(C1-C7)-alkyl, Bis-[(C1-C7)-Alkyl](aryl)silyl(C1-C7)-alkyl, [(C1-C7)-Alkyl]-bis-(aryl)silyl-(C1-C7)-alkyl, Tris- [(C1-C7)-Alkyl]silyl, Bis-hydroxyboryl-(C1-C7)-alkyl, Bis-[(C1-C7)-alkoxy]boryl-(C1-C7)-alkyl, Tetramethyl-1,3,2-Dioxaborolan-2-yl, Tetramethyl-1,3,2-Dioxaborolan-2-yl-(C1-C7)-alkyl,20 Nitro-(C1-C7)-alkyl, C(O)OR 13 , C(O)R 13 , C(O)NR 11 R 12 , R 13 O(O)C-(C1-C7)-alkyl, R 11 R 12N(O)C-(C1-C7)-alkyl, bis-(C1-C7)-alkoxy-(C1-C7)-alkyl, and wherein heterocyclyl carries n oxo groups, or R 8 and R 10 with the carbon atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted, 3 to 10-membered monocyclic or bicyclic ring, R 11 and R 12gleich oder verschieden sind und unabhängig voneinander für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C7)-Cyanoalkyl, (C1-C7)-Haloalkyl, (C2-C7)-Haloalkenyl,30 (C3-C7)-Haloalkinyl, (C3-C7)-Cycloalkyl, (C3-C7)-Halocycloalkyl, (C4-C7)-Cycloalkenyl, (C4- C7)-Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-alkyl, (C1-C7)-Haloalkoxy-(C1-C7)-alkyl, (C1- C7)-Alkylthio-(C1-C7)-alkyl, (C1-C7)-Haloalkylthio-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)- haloalkyl, Aryl, Aryl-(C1-C7)-alkyl, Heteroaryl, Heteroaryl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl- (C1-C7)-alkyl, (C4-C7)-Cycloalkenyl-(C1-C7)-alkyl, COR 13 , SO2R 14, heterocyclyl, (C1-C7)- BCS241005-Ausland STR 12 alkoxycarbonyl, bis-[(C1-C7)-alkyl]aminocarbonyl-(C1-C7)-alkyl, (C1-C7)-alkyl-amino-carbonyl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkyl-aminocarbonyl-(C1-C7)-alkyl, aryl-(C1-C7)-alkoxycarbonyl, heteroaryl-(C1-C7)-alkoxycarbonyl, (C2-C7)-alkenyloxycarbonyl, (C2-C7)-alkynyloxycarbonyl, heterocyclyl-(C1-C7)-alkyl and where heterocyclyl n carries oxo groups 5, or R 11 and R 12 with the nitrogen atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted, 3 to 10-membered monocyclic or bicyclic ring, 10 R 13für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C7)-Cyanoalkyl, (C1-C7)- Haloalkyl, (C2-C7)-Haloalkenyl, (C3-C7)-Haloalkinyl, (C3-C7)-Cycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C7)-Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-alkyl, (C1-C7)-Haloalkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-haloalkyl, (C1-C7)-Alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, (C1-C7)-15 Alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-alkoxy-(C1-C7)- alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, Aryl, Aryl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkoxy-(C1-C7)- alkyl, Heteroaryl, Heteroaryl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, (C4-C7)- Cycloalkenyl-(C1-C7)-alkyl, Bis-[(C1-C7)-alkyl]aminocarbonyl-(C1-C7)-alkyl, (C1-C7)-Alkyl- aminocarbonyl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkyl-aminocarbonyl-(C1-C7)-alkyl, Bis-[(C1-C7)-20 alkyl]amino-(C2-C6)-alkyl, (C1-C7)-Alkyl-amino-(C2-C6)-alkyl, Aryl-(C1-C7)-alkyl-amino-(C2- C6)-alkyl, R 14 S-(C1-C7)-alkyl, R 14 (O)S-(C1-C7)-alkyl, R14 O2S-(C1-C7)-alkyl, Hydroxycarbonyl- (C1-C7)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-alkyl, Tris-[(C1-C7)-Alkyl]silyl-(C1-C7)-alkyl, Bis-[(C1-C7)-Alkyl](aryl)silyl(C1-C7)-alkyl, [(C1-C7)-Alkyl]-bis-(aryl)silyl-(C1-C7)-alkyl, (C1- C7)-Alkylcarbonyloxy-(C1-C7)-alkyl, (C3-C7)-Cycloalkylcarbonyloxy-(C1-C7)-alkyl, 25 Arylcarbonyloxy-(C1-C7)-alkyl, Heteroarylcarbonyloxy-(C1-C7)-alkyl, Heterocyclylcarbonyloxy-(C1-C7)-alkyl, Aryloxy-(C1-C7)-alkyl, Heteroaryloxy-(C1-C7)-alkyl, (C1-C7)-Alkoxycarbonyl steht und wobei Heterocyclyl n Oxogruppen trägt und wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl und (C1- 30 C8)-Alkylsulfonyl, R 14für (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C7)-Cyanoalkyl, (C1-C7)-Haloalkyl, (C2-C7)-Haloalkenyl, (C3-C7)-Haloalkinyl, (C3-C7)-Cycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C7)- Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-haloalkyl, Aryl, Aryl-35 (C1-C7)-alkyl, Heteroaryl, Heteroaryl-(C1-C7)-alkyl, Heterocyclyl-(C1-C7)-alkyl, (C3-C7)- Cycloalkyl-(C1-C7)-alkyl, (C4-C7)-Cycloalkenyl-(C1-C7)-alkyl, Amino, Bis-[(C1-C7)- alkyl]amino, (C1-C7)-Alkyl-amino, Aryl-(C1-C7)-amino, Aryl-(C1-C6)-alkyl-amino, Aryl-[(C1- BCS241005-Ausland STR 13 C7)-alkyl]amino;(C3-C7)-cycloalkyl-amino, (C3-C7)-cycloalkyl-[(C1-C7)-alkyl]amino, N-acetidinyl, N-pyrrolidinyl, N-piperidinyl, N-morpholinyl, wherein the last twelve residues are bonded only to sulfonyl groups and wherein heterocyclyl carries n oxo groups, and wherein cycloalkyl may be substituted by one or more substituents selected from 5 of a group consisting of (C1-C8)-alkyl, (C1-C8)-haloalkyl, halogen, cyano, carbamoyl and (C1-C8)-alkylsulfonyl, R; 15 and R 16 independently of each other stand for (C1-C7)-alkyl, (C3-C7)-cycloalkyl, aryl, heteroaryl, heterocyclyl and where heterocyclyl carries n oxo groups, or 10 R 15 and R 16 with the carbon atom to which they are bonded, they form a fully saturated monocyclic carbocycle of 3 to 7 members, R 17 , R 18 , R 19 and R 20independently of one another stand for hydrogen, halogen, (C1-C7)-alkyl, (C1-C7)-alkoxy, (C1-C7)-haloalkoxy, (C3-C7)-cycloalkyl, (C1-C7)-haloalkyl, and n stands for 0, 1, or 2. 20 Particularly preferred subject matter of the invention is compounds of the general formula (I), wherein M represents the groups M -1 M-2 M-3 25, where the dashed line marks the link to the rest of formula (I), R 1 for aryl or heteroaryl, 30 wherein the aryl or heteroaryl group is optionally further substituted by 1, 2 or 3 substituents bonded to ring carbon atoms and chosen independently of one another R 4 , BCS241005-Abroad STR 14 and where, if applicable, two adjacent substituents R 4with the ring carbon atoms to which they are bonded, can form a saturated, partially saturated or unsaturated 5- to 7-membered ring, optionally interrupted by heteroatoms and optionally further substituted, 5 or R 1 represents a five- or six-membered heterocyclyl, which may be saturated or partially saturated, which may contain one to four heteroatoms and which bears n oxo groups, wherein each heteroatom is independently chosen from a group consisting of oxygen, nitrogen, and sulfur, and wherein the heterocyclyl residue is optionally substituted 10 by one, two, or three substituents, which are independently chosen from a group consisting of (C1-C6)-alkyl, (C1-C6)-haloalkyl, (C1-C6)-cycloalkyl, (C1-C6)-alkoxy, (C1-C6)-alkoxy-(C1-C6)-alkyl, (C2-C6)-alkenyl, (C1-C6)-haloalkoxy, halogen, aryl, heteroaryl, (heterocyclyl)aryl; 15 R 2 stands for hydrogen, R 3für (C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, (C2-C6)-Alkenyl, R 13 O-(C1-C6)-alkyl, (C3-C6)- Cycloalkyl-(C1-C6)-alkyl steht, 20 R 4 für Halogen, Cyano, Thiocyanato, Isothiocyanato, Pentafluorsulfanyl, Nitro, Aryldiazo, NR 11 R 12 , OR 13 , SR 14 , S(O)R 14 , SO2R 14 , S(O)(=N-R 11 )R 14 , S(O)(=N-R 11 )OR 13 , OSO2-Aryl, OSO2- (C1-C6)-alkyl, OSO2-(C1-C6)-haloalkyl, OSO2-(C3-C6)-cycloalkyl, C(O)OR 13 , C(O)R 13 C(O)NR 11 R 12 , C(S)NR 11 R 12 , -C=NOR 13 , R 13 OOC-(C1-C6)-alkyl, R 13 O-(C1-C6)-alkyl, R 13 S-(C1- C6)-alkyl, R 13(O)C-(C1-C6)-alkyl, (C1-C6)-Alkyl, Cyano-(C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2- 25 C6)-Alkinyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C2-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, (C1-C6)- Haloalkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-haloalkyl, (C4-C6)-Cycloalkenyl- (C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-haloalkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-30 alkyl, Aryl-(C1-C6)-alkinyl, Heteroaryl-(C1-C6)-alkinyl, Heterocyclyl-(C1-C6)-alkinyl, Tris-[(C1- C6)-alkyl]silyl-(C2-C6)-alkinyl, Bis-[(C1-C6)-alkyl](aryl)silyl-(C2-C6)-alkinyl, Bis-aryl[(C1-C6)- alkyl]silyl-(C2-C6)-alkinyl, (C3-C6)-Cycloalkyl-(C2-C6)-alkinyl, Aryl-(C2-C6)-alkenyl, Heteroaryl-(C2-C6)-alkenyl, Heterocyclyl-(C2-C6)-alkenyl, (C3-C6)-Cycloalkyl-(C2-C6)-alkenyl, Cyano-(C3-C6)-Cycloalkylaminosulfonylamino, Tris-[(C1-C6)-alkyl]silyl,Bis-[(C1-C6)-35 alkyl](aryl)silyl, bis-aryl[(C1-C6)-alkyl]silyl, wherein heterocyclyl carries n oxo groups, and wherein cycloalkyl may be substituted by one or more substituents selected from a group consisting of (C1-C8)-alkyl, (C1-C8)-haloalkyl, halogen, cyano, carbamoyl BCS241005-Ausland STR 15 and (C1-C8)-alkylsulfonyl, and wherein aryl or heteroaryl groups may be substituted by one or two alkoxycarbonyl groups, R, 5 , R 6 independently of each other stand for hydrogen, halogen, (C1-C6) alkyl, 5 R 7 Q represents hydrogen, halogen, (C1-C6)-alkyl, (C1-C7)-alkoxy, (C1-C7)-haloalkoxy, (C3-C6)-cycloalkyl, (C1-C6)-haloalkyl, Q represents hydroxy or a residue of the following formulas 10 Q-1 Q-2 stands,R 8 for hydrogen, (C1-C6)-alkyl, (C1-C6)-haloalkyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, (C2-C6)-alkynyl, (C2-C6)-alkenyl, C(O)R 13 , C(O)OR 13, (C1-C6)-Alkoxy-(C1-C6)-alkyl steht, 15 R 9 für Wasserstoff oder (C1-C6)-Alkyl steht, R 10 für Wasserstoff, Halogen, Cyano, NO2, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C3-C6)-Halocycloalkyl, (C3-C6)-Halocycloalkyl-(C1-C6)- alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1- 20 C6)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-alkyl, R 11 R 12 N-(C1-C6)-alkyl, R 13 O-(C1-C6)-alkyl, Cyano-(C1-C6)-alkyl, (C1-C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- carbonyloxy-(C1-C6)-alkyl, Arylcarbonyloxy-(C1-C6)-alkyl, Heteroarylcarbonyloxy-(C1-C6)- alkyl, Heterocyclylcarbonyloxy-(C1-C6)-alkyl, OR 13 , NR 11 R 12 , SR 14 , S(O)R 14 , SO2R 14 , R 14 S-(C1- C6)-alkyl, R 14 (O)S-(C1-C6)-alkyl, R 14O2S-(C1-C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl,25 Bis-[(C1-C6)-Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, Tris-[(C1-C6)-alkyl]silyl, bis-hydroxyboryl-(C1-C6)-alkyl, bis-[(C1-C6)-alkoxy]boryl-(C1-C6)-alkyl, tetramethyl-1,3,2-dioxaborolan-2-yl, Tetramethyl-1,3,2-dioxaborolan-2-yl-(C1-C6)-alkyl, nitro-(C1-C6)-alkyl, C(O)OR 13 , C(O)R 13 , C(O)NR 11 R 12 , R 13 O(O)C-(C1-C6)-alkyl, R 11 R 12 N(O)C- (C1-C6)-alkyl, bis-(C1-C6)-alkoxy-(C1-C6)-alkyl and wherein heterocyclyl n carries oxo groups 30, or R 8 and R 10 with the carbon atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted, 3 to 10-membered monocyclic or bicyclic ring, BCS241005-Ausland STR 16 R 11 and R 12gleich oder verschieden sind und unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4- 5 C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1- C6)-Alkylthio-(C1-C6)-alkyl, (C1-C6)-Haloalkylthio-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)- haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- (C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, COR 13 , SO2R 14, heterocyclyl, (C1-C6)-alkoxycarbonyl, bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-alkyl-amino-10 carbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxycarbonyl, heteroaryl-(C1-C6)-alkoxycarbonyl, (C2-C6)-alkenyloxycarbonyl, (C2-C6)-alkynyloxycarbonyl, heterocyclyl-(C1-C6)-alkyl and where heterocyclyl carries n oxo groups, or 15 R 11 and R 12 with the nitrogen atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted, 3 to 10-membered monocyclic or bicyclic ring, R 13für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)- 20 Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)- Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)- alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, Aryl, Aryl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxy-(C1-C6)-25 alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)- Cycloalkenyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-Alkyl- aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Bis-[(C1-C6)- alkyl]amino-(C2-C6)-alkyl, (C1-C6)-Alkyl-amino-(C2-C6)-alkyl, Aryl-(C1-C6)-alkyl-amino-(C2- C6)-alkyl, R 14 S-(C1-C6)-alkyl, R 14 (O)S-(C1-C6)-alkyl, R14 O2S-(C1-C6)-alkyl, Hydroxycarbonyl- 30 (C1-C6)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl, Bis-[(C1-C6)-Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, (C1- C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkylcarbonyloxy-(C1-C6)-alkyl, Arylcarbonyloxy-(C1-C6)-alkyl, Heteroarylcarbonyloxy-(C1-C6)-alkyl, Heterocyclylcarbonyloxy-(C1-C6)-alkyl, Aryloxy-(C1-C6)-alkyl, Heteroaryloxy-(C1-C6)-alkyl, 35 (C1-C6)-Alkoxycarbonyl steht und wobei Heterocyclyl n Oxogruppen trägt und wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer BCS241005-Ausland STR 17 Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl und (C1- C8)-Alkylsulfonyl, R 14für (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, 5 (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)- Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1- C6)-haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, Heterocyclyl-(C1- C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, Amino, Bis- [(C1-C6)-alkyl]amino, (C1-C6)-Alkyl-amino, Aryl-(C1-C6)-amino, Aryl-(C1-C6)-alkyl-amino,10 Aryl-[(C1-C6)-alkyl]amino; (C3-C6)-Cycloalkyl-amino, (C3-C6)-Cycloalkyl-[(C1-C6)- alkyl]amino;N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl, N-Morpholinyl, wherein the last twelve residues are bonded only to sulfonyl groups and wherein Heterocyclyl carries n oxo groups, and wherein Cycloalkyl may be substituted by one or more substituents selected from a group consisting of (C1-C8)-alkyl, (C1-C8)-haloalkyl, 15 halogen, cyano, carbamoyl and (C1-C8)-alkylsulfonyl, R; 15 and R 16 independently of each other stand for (C1-C6)-alkyl, (C3-C6)-cycloalkyl, aryl, heteroaryl, heterocyclyl and where heterocyclyl carries n oxo groups, or 20 R 15 and R 16 with the carbon atom to which they are bonded, they form a fully saturated monocyclic carbocycle of 3 to 7 members, R 17 , R 18 , R 19 and R 2025 and n represent 0, 1, or 2, independently of one another, hydrogen, halogen, (C1-C6)-alkyl, (C1-C6)-alkoxy, (C1-C6)-haloalkoxy, (C3-C6)-cycloalkyl, (C1-C6)-haloalkyl. 30 Particularly preferred subject matter of the invention is compounds of the general formula (I), wherein M represents the groups BCS241005-Ausland STR 18 M -1 M-2 M-3 stands, where the dashed line marks the point of connection to the rest of formula (I), 5 R 1 R stands for aryl or heteroaryl, wherein the aryl or heteroaryl group may be further substituted by 1, 2 or 3 independently chosen substituents bonded to ring carbon atoms 4 , 10 and where, if applicable, two adjacent substituents R 4with the ring carbon atoms to which they are bonded, can form a saturated, partially saturated or unsaturated 5- to 7-membered ring, optionally interrupted by heteroatoms and optionally further substituted, 15 or R 1 stands for a five- or six-membered heterocyclyl, which may be saturated or partially saturated, which may contain one to four heteroatoms and which bears n oxo groups, wherein each heteroatom is independently chosen from a group consisting of oxygen, nitrogen, and sulfur, and wherein the heterocyclyl residue is optionally substituted by one, two, or three substituents, which are independently chosen from a group consisting of (C1-C4)-alkyl, (C1-C4)-haloalkyl, (C1-C4)-cycloalkyl, (C1-C4)-alkoxy, (C1-C4)-alkoxy-(C1-C4)-alkyl, (C2-C4)-alkenyl, (C1-C4)-haloalkoxy, halogen, aryl, heteroaryl, (heterocyclyl)aryl; R 2 stands for hydrogen, 25 R 3für (C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, (C2-C6)-Alkenyl, R 13 O-(C1-C6)-alkyl, (C3-C6)- Cycloalkyl-(C1-C6)-alkyl steht, R 4 für Halogen, Cyano, Thiocyanato, Isothiocyanato, Pentafluorsulfanyl, Nitro, Aryldiazo,30 NR 11 R 12 , OR 13 , SR 14 , S(O)R 14 , SO2R 14 , S(O)(=N-R 11 )R 14 , S(O)(=N-R 11 )OR 13 , OSO2-Aryl, OSO2- (C1C5)-alkyl, OSO2-(C1C5)-haloalkyl, OSO2-(C3C6)-cycloalkyl, C(O)OR 13 , C(O)R 13 , C(O)NR 11 R 12 , C(S)NR 11 R 12 , -C=NOR 13 , R 13 OOC-(C1-C6)-alkyl, R 13 O-(C1-C6)-alkyl, R 13 S-(C1- BCS241005-Ausland STR 19 C6)-alkyl, R 13(O)C-(C1-C6)-alkyl, (C1-C6)-Alkyl, Cyano-(C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2- C6)-Alkinyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C2-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, (C1-C6)- Haloalkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, 5 (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-haloalkyl, (C4-C6)-Cycloalkenyl- (C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-haloalkyl, Heterocyclyl, Heterocyclyl-(C1-C6)- alkyl, Aryl-(C1-C6)-alkinyl, Heteroaryl-(C1-C6)-alkinyl, Heterocyclyl-(C1-C6)-alkinyl, Tris-[(C1- C6)-alkyl]silyl-(C2-C6)-alkinyl, Bis-[(C1-C6)-alkyl](aryl)silyl-(C2-C6)-alkinyl, Bis-aryl[(C1-C6)- alkyl]silyl-(C2-C6)-alkinyl, (C3-C6)-Cycloalkyl-(C2-C6)-alkinyl, Aryl-(C2-C6)-alkenyl, 10 Heteroaryl-(C2-C6)-alkenyl, Heterocyclyl-(C2-C6)-alkenyl, (C3-C6)-Cycloalkyl-(C2-C6)-alkenyl, Cyano-(C3-C6)-Cycloalkylaminosulfonylamino, Tris-[(C1-C6)-alkyl]silyl,Bis-[(C1-C6)-alkyl](aryl)silyl, bis-aryl[(C1-C6)-alkyl]silyl, wherein heterocyclyl carries n oxo groups, and wherein cycloalkyl may be substituted by one or more substituents selected from a group consisting of (C1-C8)-alkyl, (C1-C8)-haloalkyl, halogen, cyano, carbamoyl 15, and (C1-C8)-alkylsulfonyl, and wherein aryl or heteroaryl groups may be substituted by one or two alkoxycarbonyl groups, R, 5 , R 6 stand for hydrogen, 20 R 7 Q represents hydrogen, halogen, (C1-C6)-alkyl, (C1-C6)-alkoxy, (C1-C6)-haloalkoxy, (C3-C6)-cycloalkyl, (C1-C6)-haloalkyl, Q represents hydroxy or a residue of the following formulas Q -1 Q-2 steht, 25 R 8 for hydrogen, (C1-C6)-alkyl, (C1-C6)-haloalkyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, (C2-C6)-alkynyl, (C2-C6)-alkenyl, C(O)R 13 , C(O)OR 13 , (C1-C6)-alkoxy-(C1-C6)-alkyl, R 9 for hydrogen or (C1-C6) alkyl, 30 R 10für Wasserstoff, Halogen, Cyano, NO2, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C3-C6)-Halocycloalkyl, (C3-C6)-Halocycloalkyl-(C1-C6)- alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1- C6)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-alkyl, R 11 R 12 N-(C1-C6)-alkyl, R 13 O-(C1-C6)-alkyl, BCS241005-Ausland STR 20 Cyano-(C1-C6)-alkyl, (C1-C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- carbonyloxy-(C1-C6)-alkyl, Arylcarbonyloxy-(C1-C6)-alkyl, Heteroarylcarbonyloxy-(C1-C6)- alkyl, Heterocyclylcarbonyloxy-(C1-C6)-alkyl, OR 13 , NR 11 R 12 , SR 14 , S(O)R 14 , SO2R 14 , R 14 S-(C1- C6)-alkyl, R 14 (O)S-(C1-C6)-alkyl, R 14O2S-(C1-C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl, 5 Bis-[(C1-C6)-Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, Tris-[(C1-C6)-alkyl]silyl, bis-hydroxyboryl-(C1-C6)-alkyl, bis-[(C1-C6)-alkoxy]boryl-(C1-C6)-alkyl, tetramethyl-1,3,2-dioxaborolan-2-yl, Tetramethyl-1,3,2-dioxaborolan-2-yl-(C1-C6)-alkyl, nitro-(C1-C6)-alkyl, C(O)OR 13 , C(O)R 13 , C(O)NR 11 R 12 , R 13 O(O)C-(C1-C6)-alkyl, R 11 R 12 N(O)C-(C1-C6)-alkyl, bis-(C1-C6)-alkoxy-(C1-C6)-alkyl, and wherein heterocyclyl n carries oxo groups 10, or R 8 and R 10 with the carbon atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted, 3 to 10-membered monocyclic or bicyclic ring, 15 R 11 and R 12gleich oder verschieden sind und unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4- C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-20 C6)-Alkylthio-(C1-C6)-alkyl, (C1-C6)-Haloalkylthio-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)- haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- (C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, COR 13 , SO2R 14, heterocyclyl, (C1-C6)-alkoxycarbonyl, bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-alkyl-amino-carbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-25 alkoxycarbonyl, heteroaryl-(C1-C6)-alkoxycarbonyl, (C2-C6)-alkenyloxycarbonyl, (C2-C6)-alkynyloxycarbonyl, heterocyclyl-(C1-C6)-alkyl and where heterocyclyl carries n oxo groups, or R 11 and R 12 with the nitrogen atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted, 3 to 10-membered monocyclic or bicyclic ring, R 13für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)- Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, 35 (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)- Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)- BCS241005-Ausland STR 21 alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, Aryl, Aryl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxy-(C1-C6)- alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)- Cycloalkenyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-Alkyl- aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Bis-[(C1-C6)- 5 alkyl]amino-(C2-C6)-alkyl, (C1-C6)-Alkyl-amino-(C2-C6)-alkyl, Aryl-(C1-C6)-alkyl-amino-(C2- C6)-alkyl, R 14 S-(C1C6)-alkyl, R 14(O)S-(C1C6)-alkyl, R 14 O2S-(C1-C6)-alkyl, Hydroxycarbonyl- (C1-C6)-alkyl, Heterocyclyl, Heterocyclyl-(C1C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl, Bis-[(C1-C6)-Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, (C1- C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkylcarbonyloxy-(C1-C6)-alkyl, 10 Arylcarbonyloxy-(C1-C6)-alkyl, Heteroarylcarbonyloxy-(C1-C6)-alkyl, Heterocyclylcarbonyloxy-(C1-C6)-alkyl, Aryloxy-(C1-C6)-alkyl, Heteroaryloxy-(C1-C6)-alkyl, (C1-C6)-Alkoxycarbonyl steht und wobei Heterocyclyl n Oxogruppen trägt und wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl und (C1- 15 C8)-Alkylsulfonyl, R 14für (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)- Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-20 (C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, Heterocyclyl-(C1-C6)-alkyl, (C3-C6)- Cycloalkyl-(C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, Amino, Bis-[(C1-C6)- alkyl]amino, (C1-C6)-Alkyl-amino, Aryl-(C1-C6)-amino, Aryl-(C1-C6)-alkyl-amino, Aryl-[(C1- C6)-alkyl]amino; (C3-C6)-Cycloalkyl-amino, (C3-C6)-Cycloalkyl-[(C1-C6)-alkyl]amino;N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl, N-Morpholinyl, wherein the last twelve 25 residues are only bonded to sulfonyl groups and wherein Heterocyclyl carries n oxo groups, and wherein Cycloalkyl may be substituted by one or more substituents selected from a group consisting of (C1-C8)-alkyl, (C1-C8)-haloalkyl, halogen, cyano, carbamoyl and (C1-C8)-alkylsulfonyl, 30 R; 15 and R 16 independently of each other stand for (C1-C6)-alkyl, (C3-C6)-cycloalkyl, aryl, heteroaryl, heterocyclyl and where heterocyclyl carries n oxo groups, or R 15 and R 16 with the carbon atom to which they are bonded, form a fully saturated monocyclic carbocycle of 3 to 7 members, 35 R 17 , R 18 , R 19 and R 20Independently of one another, BCS241005-Ausland STR 22 represents hydrogen, halogen, (C1-C6)-alkyl, (C1-C6)-alkoxy, (C1-C8)-haloalkoxy, (C3-C6)-cycloalkyl, (C1-C6)-haloalkyl, and BCS241005-Ausland STR 22, and n represents 0, 1, or 2. 5 In particular, the preferred subject matter of the invention is compounds of the general formula (I), wherein M represents the groups M -1 M-2 M-3 10, where the dashed line marks the link to the rest of formula (I), R 1für Phenyl, 2-Methylphenyl, 3-Methylphenyl, 4-Methylphenyl, 2-Trifluormethylphenyl, 3-15 Trifluormethylphenyl, 4-Trifluormethylphenyl, 2-Trifluormethoxyphenyl, 3- Trifluormethoxyphenyl, 4-Trifluormethoxyphenyl, 2-Chlorphenyl, 3-Chlorphenyl, 4- Chlorphenyl, 3-Fluorphenyl, 4-Fluorphenyl, 2-Fluorphenyl, 2-Bromphenyl, 2-Iodphenyl, 3- Bromphenyl, 3-Iodphenyl, 4-Bromphenyl, 4-Iodphenyl, 2-Difluormethylphenyl, 2- Cyanophenyl, 3-Difluormethylphenyl, 3-Cyanophenyl, 4-Difluormethylphenyl, 4-Cyanophenyl, 20 2-Methoxyphenyl, 3-Methoxyphenyl, 4-Methoxyphenyl, 3,4-Difluorphenyl, 2,4-Difluorphenyl, 2,3-Difluorphenyl, 3,5-Difluorphenyl, 2,5-Difluorphenyl, 2,6-Difluorphenyl, 3,4-Dichlorphenyl, 2,4-Dichlorphenyl, 2,3-Dichlorphenyl, 3,5-Dichlorphenyl, 2,5-Dichlorphenyl, 2,6- Dichlorphenyl, 3,4-Dibromphenyl, 2,4-Dibromphenyl, 2,3-Dibromphenyl, 3,5-Dibromphenyl, 2,5-Dibromphenyl, 3,5-Diiodphenyl, 2,4-Diiodphenyl, 2,5-Diiodphenyl, 3,4-Diiodphenyl, 3-25 Fluor-4-chlorphenyl, 2-Fluor-4-chlorphenyl,2-Fluor-3-chlorphenyl, 2-Fluor-5-chlorphenyl, 3- Fluor-5-chlorphenyl, 2-Fluor-6-chlorphenyl, 3-Fluor-5-bromphenyl, 3-Fluor-5-iodphenyl, 3- Fluor-4-bromphenyl, 3-Fluor-4-iodphenyl, 2-Fluor-4-trifluormethylphenyl, 2-Fluor-4- methylphenyl, 2-Fluor-4-trifluormethoxyphenyl, 2-Fluor-4-trifluormethylsulfanylphenyl, 2- Fluor-4-cyanophenyl, 2-Fluor-4-methoxyphenyl, 2-Fluor-4-methoxycarbonylphenyl, 2-Fluor-4-30 hydroxycarbonylphenyl, 2-Fluor-6-trifluormethylphenyl, 2-Fluor-6-methylphenyl, 2-Fluor-6- trifluormethoxyphenyl, 2-Fluor-6-trifluormethylsulfanylphenyl, 2-Fluor-6-cyanophenyl, 2- Fluor-6-methoxyphenyl, 2-Fluor-6-methoxycarbonylphenyl, 2-Fluor-6-hydroxycarbonylphenyl, BCS241005-Ausland STR 23 3-Fluor-5-methoxycarbonylphenyl, 3-Fluor-5-hydroxycarbonylphenyl, 3-Fluor-5-cyanophenyl, 3-Fluor-5-methoxyphenyl, 3-Chlor-5-methoxyphenyl, 3-Brom-5-methoxyphenyl, 3-Iod-5- methoxyphenyl, 3-Chlor-4-fluorphenyl, 3-Brom-4-fluorphenyl, 3-Iod-4-fluorphenyl, 3-Brom-4- chlorphenyl, 3-Iod-4-chlorphenyl,3-Iod-4-bromphenyl, 3-Iod-5-bromphenyl, 3-Brom-4- 5 iodphenyl, 4-Brom-3-chlorphenyl, 3-Chlor-4-iodphenyl, 3-Brom-5-chlorphenyl, 3-Chlor-5- iodphenyl, 3-Chlor-5-cyanophenyl, 3-Brom-5-cyanophenyl, 3-Iod-5-cyanophenyl, 2-Chlor-4- fluorphenyl, 2-Chlor-3-fluorphenyl, 2-Chlor-5-fluorphenyl, 3-Chlor-5-cyclopropylphenyl, 3-(1- Chlorcycloprop-1-yl)-5-chlorphenyl, 3-(1-Fluorcycloprop-1-yl)-5-chlorphenyl, 3-(1- Cyanocycloprop-1-yl)-5-chlorphenyl, 3-Cyclopropyl-5-fluorphenyl, 3-(1-Chlorcycloprop-1-yl)-10 5-fluorphenyl, 3-(1-Fluorcycloprop-1-yl)-5-fluorphenyl, 3-(1-Cyanocycloprop-1-yl)-5- fluorphenyl, 3-Cyclopropyl-5-bromphenyl, 3-Cyclopropyl-5-iodphenyl, 3-(1-Chlorcycloprop-1- yl)-5-bromphenyl, 3-(1-Fluorcycloprop-1-yl)-5-bromphenyl, 3-(1-Cyanocycloprop-1-yl)-5- bromphenyl, 3-(1-Cyanocycloprop-1-yl)phenyl, 4-(1-Cyanocycloprop-1-yl)phenyl, 3-(1- Fluorcycloprop-1-yl)-5-iodphenyl, 3-(1-Fluorcycloprop-1-yl)-5-trifluormethylphenyl, 3-(1-15 Fluorcycloprop-1-yl)-5-trifluormethoxyphenyl, 3,4-Dimethylphenyl, 2,4-Dimethylphenyl, 2,3- Dimethylphenyl, 2,5-Dimethylphenyl, 2,6-Dimethylphenyl, 3-Fluor-4-methylphenyl, 3-Fluor-5- methoxyphenyl, 3-Fluor-4-methoxyphenyl, 3-Fluor-5-methylphenyl, 3,5-Dimethylphenyl, 3,5- bis(Trifluormethyl)phenyl, 2,5-bis(Trifluormethyl)phenyl, 2,4-bis(Trifluormethyl)phenyl, 2,6- bis(Trifluormethyl)phenyl, 2,3-bis(Trifluormethyl)phenyl, 3,5-bis(Difluormethyl)phenyl, 3,4-20 bis(Trifluormethyl)phenyl, 3,4-bis(Difluormethyl)phenyl, 2-Trifluormethyl-4-fluorphenyl, 3- Fluor-5-trifluormethylphenyl, 3-Chlor-5-trifluormethylphenyl, 3-Brom-5-trifluormethylphenyl, 3-Iod-5-trifluormethylphenyl, 3-Trifluormethyl-4-iodphenyl, 3-Trifluormethyl-4-bromphenyl, 3- Trifluormethyl-4-trifluormethoxyphenyl, 3-Trifluormethyl-4-difluormethoxyphenyl, 3- Trifluormethyl-4-Cyanophenyl, 3-Trifluormethyl-4-methylphenyl, 3-Trifluormethyl-4-25 fluorphenyl, 3-Brom-4-trifluormethylphenyl, 3-Iod-4-Trifluormethylphenyl, 3-Methoxy-5- trifluormethylphenyl, 3-Methyl-5-trifluormethylphenyl,3-Chlor-5-methylphenyl, 3-Brom-5- methylphenyl, 3-Iod-5-methylphenyl, 3-Difluormethoxy-5-trifluormethylphenyl, 3- Difluormethoxy-4-trifluormethylphenyl, 3-Difluormethoxy-5-trifluormethoxyphenyl, 3- Difluormethoxy-4-trifluormethoxyphenyl, 3-Difluormethoxyphenyl, 3-Chlor-5-30 difluormethoxyphenyl, 3-Chlor-4-difluormethoxyphenyl, 3-Difluormethoxy-4-chlorphenyl, 3- Brom-5-difluormethoxyphenyl, 3-Brom-4-difluormethoxyphenyl, 3-Difluormethoxy-4- bromphenyl, 3-Fluor-5-difluormethoxyphenyl, 3-Fluor-4-difluormethoxyphenyl, 3- Difluormethoxy-4-fluorphenyl, 3,5-bis(Difluormethoxy)phenyl, 3-Trifluormethoxy-5- trifluormethylphenyl, 4-Chlor-3-trifluormethoxyphenyl, 3-Cyano-5-trifluormethylphenyl, 3-35 Chlor-5-prop-2-ylphenyl, 3-Chlor-5-ethylphenyl, 3-Prop-2-yl-5-trifluormethylphenyl, 3-Ethyl-5- trifluormethylphenyl, 3-Cyclopropyl-5-trifluormethylphenyl, 3-(1-Chlorycloprop-1-yl)-5- trifluormethylphenyl, 3-(1-Fluorycloprop-1-yl)-5-trifluormethylphenyl,3-(1-Cyanoycloprop-1- BCS241005-Ausland STR 24 yl)-5-trifluormethylphenyl, 2-Chlor-5-trifluormethylphenyl, 2-Chlor-4-trifluormethylphenyl, 3- Chlor-4-trifluormethylphenyl, 2-Chlor-6-trifluormethylphenyl, 2-Trifluormethyl-4-chlorphenyl, 3-Trifluormethyl-4-chlorphenyl, 2,3,4-Trifluorphenyl, 2,3,5-Trifluorphenyl, 3,4,5- Trifluorphenyl, 2,4,5-Trifluorphenyl, 2,3,6-Trifluorphenyl, 2,4,6-Trifluorphenyl, 3,4,5- 5 Trichlorphenyl, 3-Brom-4,5-dichlorphenyl, 3-Fluor-4,5-dichlorphenyl, 4-Brom-3,5- dichlorphenyl, 3,4-Dichlor-5-trifluormethylphenyl, 3,4-Dichlor-5-trifluormethoxyphenyl, 2- Fluor-3-methoxy-4-fluorphenyl, 2,4,6-Trimethylphenyl, 3,4,5-Trimethylphenyl, 2-Fluor-3- methylphenyl, 2-Fluor-6-methylphenyl, 2-Chlor-4,5-difluorphenyl, 2-Chlor-4-fluor-5- nitrophenyl, 2-Fluor-4-nitrophenyl, 2,4-Difluor-3-chlorphenyl, 2-Chlor-3,6-difluorphenyl, 2,3-10 Dichlor-6-fluorphenyl, 2-Chlor-4-cyanophenyl, 2-Ethyl-4,6-dimethylphenyl, 2-Fluor-6- ethoxycarbonylphenyl, 2-Fluor-6-isopropyloxyphenyl, 2,6-Difluor-3-methylphenyl, 2,6-Dichlor- 3-methylphenyl, Pyridin-2-yl, Pyridin-3-yl, 2-Fluorpyridin-3-yl, 2-Chlorpyridin-3-yl, 2,4- Difluorpyridin-3-yl, 2,4-Dichlorpyridin-3-yl, 2,6-Difluorpyridin-3-yl, 2,6-Dichlorpyridin-3-yl, 3,4-Difluorpyridin-2-yl, 3,4-Dichlorpyridin-2-yl, 3,5-Difluorpyridin-2-yl, 3,5-Dichlorpyridin-2-15 yl, 5-Chlorpyridin-2-yl, 6-Chlorpyridin-2-yl, 5-Fluorpyridin-2-yl, 6-Fluorpyridin-2-yl, 5,6- Difluorpyridin-2-yl, 5,6-Dichlorpyridin-2-yl, 4,6-Difluorpyridin-2-yl, 4,6-Dichlorpyridin-2-yl, 2,5-Difluorpyridin-3-yl, 2,5-Dichlorpyridin-3-yl, 4-Fluorpyridin-3-yl, 4-Chlorpyridin-3-yl, 5- Chlorpyridin-3-yl, 5-Brompyridin-3-yl, 4-Trifluormethylpyridin-3-yl, 4-Fluorpyridin-2-yl, 4- Chlorpyridin-2-yl, 4-Methylpyridin-2-yl, 4-Trifluormethylpyridin-2-yl, 4-Methoxypyridin-2-yl,20 4-Trifluormethoxypyridin-2-yl, 5-Trifluormethylpyridin-3-yl, 5-Trifluormethoxypyridin-3-yl, 5- Methoxypyridin-3-yl, 6-Chlorpyridin-3-yl, 6-Brompyridin-3-yl, 6-Trifluormethylpyridin-3-yl,2- Trifluormethylpyridin-3-yl, 3-Fluor-5-trifluormethoxyphenyl, 3-Chlor-5-trifluormethoxyphenyl, 3-Brom-5-trifluormethoxyphenyl, 3-Iod-5-trifluormethoxyphenyl, 3-Methyl-5- trifluormethoxyphenyl, 3-Cyano-5-trifluormethoxyphenyl, 3-(Prop-2-yl)-5-25 trifluormethoxyphenyl, 3-(Prop-1-yl)-5-trifluormethoxyphenyl, 3-(But-1-yl)-5- trifluormethoxyphenyl, 3-(1,1-Dimethyleth-1-yl)-5-trifluormethoxyphenyl, 3-Vinyl-5- trifluormethoxyphenyl, 3-(Prop-1-en-2-yl)-5-trifluormethoxyphenyl, 3-(Prop-1-en-1-yl)-5- trifluormethoxyphenyl, 3-(1-Methylprop-1-en-1-yl)-5-trifluormethoxyphenyl, 3-Ethyl-5- trifluormethoxyphenyl, 3-Cyclopropyl-5-trifluormethoxyphenyl, 3-Cyclobutyl-5-30 trifluormethoxyphenyl, 3-Cyclopentyl-5-trifluormethoxyphenyl, 3-Cyclopent-1-en-1-yl-5- trifluormethoxyphenyl, 3-trimethylsilyl-5-trifluormethoxyphenyl, 3-(1-Methylprop-1-yl)-5- trifluormethoxyphenyl, 3-(1-Methylprop-2-yl)-5-trifluormethoxyphenyl, 3-(1-Chlorycloprop-1- yl)-5-trifluormethoxyphenyl,3-(1-Fluorycloprop-1-yl)-5-trifluormethoxyphenyl, 3-(1- Cyanocycloprop-1-yl)-5-trifluormethoxyphenyl, 3-(1-Cyanocycloprop-1-yl)-4-35 trifluormethoxyphenyl, 3-(1-Cyanocycloprop-1-yl)-5-trifluormethylphenyl, 3-(1- Cyanocycloprop-1-yl)-4-trifluormethylphenyl, 3,5-bis(Trifluormethoxy)phenyl, 3,4- bis(Trifluormethoxy)phenyl, 3-Methoxymethyl-5-trifluormethoxyphenyl, 3,5-Dichlorpyridin-4- BCS241005-Ausland STR 25 yl, 3,5-Difluorpyridin-4-yl, 3,5-Dibrompyridin-4-yl, 3,5-Dimethylpyridin-4-yl, 3,5- bis(trifluormethyl)pyridin-4-yl, 2,6-Dichlorpyridin-4-yl, 2,6-Difluorpyridin-4-yl, 2,6- Dibrompyridin-4-yl, 2,6-Dimethylpyridin-4-yl, 2,6-bis(trifluormethyl)pyridin-4-yl, 2- Chlorpyridin-4-yl, 2-Trifluormethylpyridin-4-yl, 3-Chlorpyridin-4-yl, 3-Trifluormethylpyridin- 5 4-yl, 3-Chlor-5-(pentafluor-λ⁶-sulfanyl)phenyl, 3-Fluor-5-(pentafluor-λ⁶-sulfanyl)phenyl, 3- Brom-5-(pentafluor-λ⁶-sulfanyl)phenyl, 1,3-Benzothiazol-5-yl, 1,3-Benzothiazol-6-yl, 2- Methoxy-1,3-benzothiazol-5-yl, 2-Methyl-1,3-benzothiazol-5-yl, 2-Chlor-1,3-benzothiazol-5-yl, Naphth-2-yl, Naphth-1-yl, 8-Bromnaphth-2-yl, 7-Bromnaphth-2-yl, 6-Bromnaphth-2-yl, 5- Bromnaphth-2-yl, 3-Chlor-5-methylsulfonylphenyl, 3-Chlor-4-(methylsulfonyl)phenyl, 3-Brom-10 5-methylsulfonylphenyl, 3-Brom-4-methylsulfonylphenyl, 3-Methylsulfonyl-4- trifluormethylphenyl, 3-(Methylsulfonyl)-4-chlorphenyl, 4-Brom-3-methylsulfonylphenyl, 3- Chlor-5-(ethylsulfonyl)phenyl, 3-Chlor-5-(prop-2-ylsulfonyl)phenyl, 3-Chlor-5- (cyclopropylsulfonyl)phenyl, 3-Methylsulfonyl-5-trifluormethylphenyl, 3-Methylsulfonyl-5- trifluormethoxyphenyl, 3-Methylsulfonyl-5-(1H-pyrazol-1-yl)phenyl, 3-Methylsulfonyl-5-(1H-15 1,2,4-triazol-1-yl)phenyl, 3-Ethylsulfonyl-5-trifluormethoxyphenyl, 3-Ethylsulfinyl-5- trifluormethoxyphenyl, 3-Ethylsulfanyl-5-trifluormethoxyphenyl, 3-Chlor-5- (methylsulfinyl)phenyl, 3-Chlor-5-(ethylsulfinyl)phenyl, 3-Chlor-5-(prop-2-ylsulfinyl)phenyl, 3- Chlor-5-(cyclopropylsulfinyl)phenyl, 3-(Methylsulfinyl)-5-trifluormethylphenyl,3- (Methylsulfinyl)-5-trifluormethoxyphenyl, 3-(Methylsulfinyl)-5-(1H-pyrazol-1-yl)phenyl, 3-20 (Methylsulfinyl)-5-(1H-1,2,4-triazol-1-yl)phenyl, 3-Chlor-5-(methylsulfanyl)phenyl, 3-Chlor-5- (ethylsulfanyl)phenyl, 3-Chlor-5-(prop-2-ylsulfanyl)phenyl, 3-Chlor-5- (cyclopropylsulfanyl)phenyl, 3-(Methylsulfanyl)-5-trifluormethylphenyl, 3-(Methylsulfanyl)-5- trifluormethoxyphenyl, 3-(Methylsulfanyl)-5-(1H-pyrazol-1-yl)phenyl, 3-Methylsulfanyl-5-(1H- 1,2,4-triazol-1-yl)phenyl, 2,3-Dihydro-1,4-benzodioxin-6-yl, 1,1,4,4-Tetraoxido-2,3-dihydro-25 1,4-benzodithiin-6-yl, 1,1,4-Trioxido-2,3-dihydro-1,4-benzodithiin-6-yl, 1,4,4-Trioxido-2,3- dihydro-1,4-benzodithiin-6-yl, 1,4-Dioxido-2,3-dihydro-1,4-benzodithiin-6-yl, 2,3-dihydro-1,4- benzodithiin-6-yl, 1,1,3,3-Tetraoxido-1,3-benzodithiol-5-yl, 1,1,3-trioxido-1,3-benzodithiol-5- yl, 1,3-dioxido-1,3-benzodithiol-5-yl, 1,3-benzodithiol-5-yl, 2,3-dihydro-1,4-benzoxathiin-6-yl, 2,3-dihydro-1,4-benzoxathiin-7-yl, 4,4-dioxido-2,3-dihydro-1,4-benzoxathiin-7-yl, 4,4-dioxido-30 2,3-dihydro-1,4-benzoxathiin-6-yl, 3,3-dioxido-1,3-benzoxathiol-5-yl, 3-Oxido-1,3- benzoxathiol-5-yl, 1,3-Benzoxathiol-5-yl, 3,3-dioxido-1,3-benzoxathiol-6-yl, 3-Oxido-1,3- benzoxathiol-6-yl, 1,3-Benzoxathiol-6-yl, 3,5-bis(Methylsulfonyl)phenyl, 3,4- bis(Methylsulfonyl)phenyl, 3,5-bis(Methylsulfanyl)phenyl, 3,4-bis(Methylsulfanyl)phenyl, 3-(4- Chlor-1H-pyrazol-1-yl)phenyl, 3-(4-Brom-1H-pyrazol-1-yl)phenyl, 3-(4-Iod-1H-pyrazol-1-35 yl)phenyl, 3-(4-Methyl-1H-pyrazol-1-yl)phenyl, 3-(4-Trifluormethyl-1H-pyrazol-1-yl)phenyl, 3- (1H-pyrazol-1-yl)phenyl, 3-(1H-pyrazol-1-yl)-5-chlorphenyl, 3-(1H-pyrazol-1-yl)-5- trifluormethylphenyl, 3-(1H-pyrazol-1-yl)-5-trifluormethoxyphenyl, 1,3-Benzodioxol-5-yl, 7- BCS241005-Ausland STR 26 chlor-1,3-benzodioxol-5-yl, 6-chlor-1,3-benzodioxol-5-yl, 5-Methylpyrazin-2-yl, 5- Trifluormethylpyrazin-2-yl, 5-Fluorpyrazin-2-yl, 5-Chlorpyrazin-2-yl, 5-Brompyrazin-2-yl, Pyrazin-2-yl, Pyridazin-4-yl, Pyridazin-3-yl,2-Methylpyrimidin-5-yl, Pyrimidin-5-yl, 3-Nitro-5- methoxyphenyl, 3-Nitro-4-methoxyphenyl, 3-Chlor-5-nitrophenyl, 3-Chlor-4-nitrophenyl, 3- 5 Nitro-4-chlorophenyl, 2-Nitro-5-trifluormethoxyphenyl, 3-Nitro-5-trifluormethylphenyl, 3- Nitro-4-trifluormethoxyphenyl, 3-Trifluormethyl-4-nitrophenyl, 3-Nitro-5- trifluormethoxyphenyl, 3-Nitrophenyl, 3-Phenyl-5-trifluormethylphenyl, 3- Methoxycarbonylphenyl-5-trifluormethylphenyl, 3,5-bis-(Trifluormethansulfonyl)phenyl, 3- Fluor-5-[(trifluormethyl)sulfonyl]phenyl, 3-Chlor-5-[(trifluormethyl)sulfonyl]phenyl, 3-Brom-5-10 [(trifluormethyl)sulfonyl]phenyl, 3-[(1-Cyanocycloprop-1-yl)-1-sulfonyl]-5- trifluormethoxyphenyl, 3-(1-Carbamoylcyclopropyl)-5-Trifluormethylsulfonylphenyl, 3-(2- Cyanopropyl-2-sulfonyl)-5-trifluormethoxyphenyl, 3-(1-Cyano-1-methyleth-1-yl)-5- trifluormethylsulfonylphenyl, 3-(1-Cyanocycloprop-1-yl)-5-(trifluormethylsulfonyl)phenyl, 3- (1-Cyano-1-methyleth-1-yl)-5-trifluormethylphenyl,3-(1-Cyano-1-methyl-ethyl)-5-15 trifluormethoxyphenyl, 3-[(Difluormethyl)sulfonyl]-5-trifluormethoxyphenyl, 3,5-bis- (difluormethylsulfonyl)phenyl, 3-(1-Methylsulfonylcyclopropyl)-5-trifluormethoxyphenyl, 3- Cyclopropylsulfamoyl-5-trifluormethoxyphenyl, 3-Methylsulfamoyl-5-trifluormethoxyphenyl, 3-Sulfamoyl-5-trifluormethoxyphenyl, 3-(1-methyl-1-methylsulfonylethyl)-5- trifluormethoxyphenyl, 3-Brom-5-[Brom(difluor)methyl]phenyl, 3-Chlor-5-20 [chlor(difluor)methyl]phenyl, 3-Chlor-5-(2-chlor-1,1,2,2-tetrafluorethoxyphenyl, 3-(1- Methylsulfonylcyclopropyl)-5-trifluormethylphenyl, 3-Chlor-5-[1- (trifluormethyl)cyclopropyl]phenyl, 3-Brom-5-[1-(trifluormethyl)cyclopropyl]phenyl, 3-Bromo- 5-(2,2-dichlorcyclopropyl)phenyl, 3-Chlor-5-(2,2-dichlorcyclopropyl)phenyl, 3-Fluor-5-(2,2- dichlorcyclopropyl)phenyl, 3-Cyclopropylsulfonyl-5-trifluormethoxyphenyl, 3- 25 Cyclobutylsulfonyl-5-trifluormethoxyphenyl, 3-[(Prop-1-yl)sulfonyl]-5-trifluormethoxyphenyl,3-[Prop-2-ylsulfonyl]-5-trifluormethoxyphenyl, 3-[1-Methyl-1-(methylsulfonyl)ethyl]-5- trifluormethylphenyl, 3-Methylsulfonyl-5-(1,1,2,2-tetrafluorethoxy)phenyl, 3-Brom-5-(1,1,2,2- tetrafluorethoxy)phenyl, 3,5-bis-(1,1,2,2-tetrafluorethoxy)phenyl, 3-(trifluormethoxy)-5- vinylphenyl, 3-formyl-5-trifluormethoxyphenyl, 3-[(Z)-(methoxyimino)methyl]-5-30 trifluormethoxyphenyl, 3-[(E)-(methoxyimino)methyl]-5-trifluormethoxyphenyl, 3-[(Z)- (ethoxyimino)methyl]-5-trifluormethoxyphenyl, 3-[(E)-(ethoxyimino)methyl]-5- trifluormethoxyphenyl, 3-[(Z)-(hydroxyimino)methyl]-5-trifluormethoxyphenyl, 3-[(E)- (hydroxyimino)methyl]-5-trifluormethoxyphenyl, 2-(2,2-Difluorcyclopropyl)phenyl, 2-(2,2- Dibromcyclopropyl)phenyl, 2-(2-Brom-2-Methylcyclopropyl)phenyl, 2-(2-35 Methylencyclopropyl)phenyl, 2-[1,1'-Bi(cyclopropyl)-1-yl]phenyl, 2-(Spiro[2.2]pentan-1- yl)phenyl, 3-(2,2-Difluorcyclopropyl)phenyl, 3-(2-Brom-2-Methylcyclopropyl)phenyl, 3-(2- Methylencyclopropyl)phenyl, 3-[1,1'-Bi(cyclopropyl)-1-yl]phenyl, 3-(Spiro[2.2]pentan-1- BCS241005-Ausland STR 27 yl)phenyl, 3-Chlor-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-Brom-5-methyl-4,5-dihydro-1,2- oxazol-5-yl, 3,5-Dimethyl-4,5-dihydro-1,2-oxazol-5-yl, 3-Trifluormethyl-5-methyl-4,5-dihydro- 1,2-oxazol-5-yl, 3-(5-Amino-2-chlor-4-fluorphenyl)-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3- (5-Nitro-2-chlor-4-fluorphenyl)-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-[2-Chlor-5-(3,5- 5 dimethyl-2,6-dioxo-4-sulfanyliden-1,3,5-triazinan-1-yl)-4-fluorphenyl]-5-methyl-4,5-dihydro- 1,2-oxazol-5-yl, 3-{2-Chlor-4-fluor-5-[3-methyl-2,6-dioxo-4-(trifluormethyl)-3,6- dihydropyrimidin-1(2H)-yl]phenyl}-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-{2-Brom-4-fluor- 5-[3-methyl-2,6-dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}-5-methyl-4,5- dihydro-1,2-oxazol-5-yl, 3-{2-Iod-4-fluor-5-[3-methyl-2,6-dioxo-4-(trifluormethyl)-3,6-10 dihydropyrimidin-1(2H)-yl]phenyl}-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-{5-[3-Amino-2,6- dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]-2-chlor-4-fluorphenyl}-5-methyl-4,5- dihydro-1,2-oxazol-5-yl, 3-{5-[3-Amino-2,6-dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin- 1(2H)-yl]-2-brom-4-fluorphenyl}-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-{5-[3-Amino-2,6- dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]-2-iod-4-fluorphenyl}-5-methyl-4,5-15 dihydro-1,2-oxazol-5-yl, 2-{5-[3-Amino-2,6-dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin- 1(2H)-yl]-2-chlor-4-fluorphenyl}-1,3-thiazol-5-yl, 2-{5-[3-Amino-2,6-dioxo-4-(trifluormethyl)- 3,6-dihydropyrimidin-1(2H)-yl]-2-brom-4-fluorphenyl}-1,3-thiazol-5-yl, 2-{5-[3-Amino-2,6- dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]-2-iod-4-fluorphenyl}-1,3-thiazol-5-yl, 2-{2-Chlor-4-fluor-5-[3-methyl-2,6-dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin-1(2H)-20 yl]phenyl}-1,3-thiazol-5-yl, 2-{2-Brom-4-fluor-5-[3-methyl-2,6-dioxo-4-(trifluormethyl)-3,6- dihydropyrimidin-1(2H)-yl]phenyl}-1,3-thiazol-5-yl,2-{2-Iod-4-fluor-5-[3-methyl-2,6-dioxo-4- (trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}-1,3-thiazol-5-yl, 2-[2-Chlor-5-(3,5- dimethyl-2,6-dioxo-4-sulfanyliden-1,3,5-triazinan-1-yl)-4-fluorphenyl]-1,3-thiazol-5-yl, 1,3- Thiazol-5-yl, 1,3-Thiazol-4-yl, 2-Chlor-1,3-thiazol-5-yl, 2-Chlor-1,3-thiazol-4-yl, 2-Methyl-1,3- 25 thiazol-5-yl, 2-Methyl-1,3-thiazol-4-yl, 4-Methyl-1,3-thiazol-2-yl, 5-Methyl-1,3-thiazol-2-yl, Thien-2-yl, Thien-3-yl, 5-Chlorthien-2-yl, 5-Bromthien-2-yl, 4-Chlorthien-2-yl, 4-Bromthien-2- yl, 3-Chlorthien-2-yl, 3-Bromthien-2-yl, 4,5-Dichlorthien-2-yl, 4,5-Dibromthien-2-yl, 3,4- Dichlorthien-2-yl, 3,4-Dibromthien-2-yl, 4-Brom-3-methoxythien-2-yl, 4-Brom-3-methylthien- 2-yl, 5-(1-Cyanocycloprop-1-yl)thien-2-yl, 3-Trifluormethylthien-2-yl, 4-Trifluormethylthien-2-30 yl, 5-Trifluormethylthien-2-yl, 3-Trifluormethoxythien-2-yl, 4-Trifluormethoxythien-2-yl, 3- Difluormethoxythien-2-yl, 4-Difluormethoxythien-2-yl, 3-Difluormethoxy-5-methylthien-2-yl,4-Chlorthien-3-yl, 5-Chlorthien-3-yl, 2-Chlorthien-3-yl, 4-Bromthien-3-yl, 4-Methylthien-3-yl, 2,4-Dichlorthien-3-yl, 2,5-Dichlorthien-3-yl, 1-Methyl-1H-pyrazol-5-yl, 1-Ethyl-1H-pyrazol-5- yl, 4-Chlor-1,3-Dimethyl-1H-pyrazol-5-yl, 1,3-Dimethyl-1H-pyrazol-5-yl, 4-Chlor-1H-pyrazol-35 5-yl, 1-Methyl-1H-pyrazol-4-yl, 4-Methyl-1,2,3-thiadiazol-5-yl, 3-Methyl-1,2-oxazol-5-yl, 4- Methyl-1,2-oxazol-5-yl, 5-Methyl-1,2-oxazol-3-yl, 4-Methyl-1,3-oxazol-5-yl, 4,5-Dichlor-1,2- thiazol-3-yl, 1,2-Thiazol-3-yl, 1,2-Thiazol-5-yl, 4-Chlor-1,2-thiazol-5-yl, 3-Chlor-1,2-thiazol-5- BCS241005-Ausland STR 28 yl, 3,4-Dichlor-1,2-thiazol-5-yl, 3-Chlor-4-Cyano-1,2-thiazol-5-yl, 1,2-Benzoxazol-3-yl, 1,2- Benzothiazol-3-y1, 7-Chlor-1,2-benzothiazol-3-yl, 3-Trimethylsilyl-5-trifluormethylphenyl, 3,5- bis(Trimethylsilyl)phenyl, 3-(1,1-Dimethyleth-1-yl)-5-trifluormethyl, 3-Methylsulfonyl-5- (1,1,2,2-tetrafluoroethyl)phenyl, 3-Brom-5-(1,1,2,2-tetrafluoroethyl)phenyl, 3-Chlor-5-(1,1,2,2- 5 tetrafluoroethyl)phenyl 3-Fluor-5-(1,1,2,2-tetrafluoroethyl)phenyl, 3-Brom-5- cyclopropylsulfonylphenyl, 3-Cyclopropylsulfonyl-5-trimethylsilylphenyl, 3- Cyclopropylsulfonyl-5-trifluormethylphenyl, 3-[cyclopropyl(difluoro)methyl]-5- trifluoromethoxyphenyl, 3-[Cyclopropyl(difluor)methyl]-5-trifluoromethylphenyl, 3-Brom-5- [cyclopropyl(difluor)methyl]phenyl, 3-Chlor-5-[cyclopropyl(difluor)methyl]phenyl, 3-Fluor-5-10 [cyclopropyl(difluor)methyl]phenyl, 3-[Cyclopropyl(difluor)methyl]-5-methylsulfonylphenyl, 3- [Chlor(difluor)methyl]-5-methylsulfonylphenyl, 3,5-bis[Chlor(difluor)methyl]phenyl, 3-(1,1- Difluoreth-1-yl)-5-trifluormethylphenyl, 3-(1,1-Difluoreth-1-yl)-5-trifluormethoxyphenyl, 3- (1,1-Difluoreth-1-yl)-5-chlorphenyl, 3-(1,1-Difluoreth-1-yl)-5-bromphenyl, 3- trifluormethylsulfanylphenyl, 3-trifluormethylsulfanyl-5-chlorphenyl, 3-trifluormethylsulfanyl- 15 5-fluorphenyl, 3-trifluormethylsulfanyl-5-bromphenyl, 3-trifluormethylsulfanyl-4-chlorphenyl,3-trifluormethylsulfanyl-4-fluorphenyl, 3-trifluormethylsulfanyl-4-bromphenyl, 3-(4- Methoxycarbonylphenyl)-5-trifluormethylphenyl, 3-(Oxetan-3-yl)phenyl, 3-(3-Fluoroxetan-3- yl)phenyl, 3-(Oxetan-3-yl)-5-trifluormethoxyphenyl, 3-(3-Fluoroxetan-3-yl)-5- trifluormethylphenyl, 4-Trifluormethylsulfanylpyridin-3-yl, 5-Trifluormethylsulfanylpyridin-3-20 yl, 6-Trifluormethylsulfanylpyridin-3-yl, 3-(Methylsulfonyloxy)phenyl, 3-(Methylsulfonyloxy)- 5-chlorphenyl, 3-(Methylsulfonyloxy)-5-trifluormethylphenyl, 3-(Methylsulfonyloxy)-5- trifluormethoxyphenyl, 3-(Trifluormethylsulfonyloxy)phenyl, 3-(Trifluormethylsulfonyloxy)-5- chlorphenyl, 3-(Trifluormethylsulfonyloxy)-5-trifluormethylphenyl, 3- (Trifluormethylsulfonyloxy)-5-trifluormethoxyphenyl, 4-(Methylsulfonyloxy)phenyl, 3-25 (Methylsulfonyloxy)-4-chlorphenyl, 3-(Methylsulfonyloxy)-4-trifluormethylphenyl, 3- (Methylsulfonyloxy)-4-trifluormethoxyphenyl, 3-chlor-4-(Methylsulfonyloxy)phenyl, 3- Trifluormethyl-4-(methylsulfonyloxy)phenyl,3-Trifluormethoxy-4-(methylsulfonyloxy)phenyl, 3-(3-Methyl-1,2,4-oxadiazol-5-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(3-methyl-1,2,4- oxadiazol-5-yl)phenyl, 4-Chlor-3-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl, 3-(5-Methyl-1,3,4-30 oxadiazol-2-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl, 4- Chlor-3-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl, 3-(5-Methyl-1,2,4-oxadiazol-3-yl)-5- (trifluormethoxy)phenyl, 3-Chlor-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl, 4-Chlor-3-(5- methyl-1,2,4-oxadiazol-3-yl)phenyl, 3-(2,5-Dioxoimidazolidin-4-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(2,5-dioxoimidazolidin-4-yl)phenyl, 4-Chlor-3-(2,5-dioxoimidazolidin-4-yl)phenyl,35 3-(5-Oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(5-oxo-4,5- dihydro-1H-1,2,4-triazol-3-yl)phenyl, 4-Chlor-3-(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3- yl)phenyl, 3-(5-Oxo-4,5-dihydro-1H-pyrazol-3-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(5- BCS241005-Ausland STR 29 oxo-4,5-dihydro-1H-pyrazol-3-yl)phenyl, 4-Chlor-3-(5-oxo-4,5-dihydro-1H-pyrazol-3- yl)phenyl, 3-(1,3-Thiazol-2-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(1,3-thiazol-2-yl)phenyl, 4-Chlor-3-(1,3-thiazol-2-yl)phenyl, 3-(2-Methyl-1,3-thiazol-5-yl)-5-(trifluormethoxy)phenyl, 3- Chlor-5-(2-methyl-1,3-thiazol-5-yl)phenyl, 4-Chlor-3-(2-methyl-1,3-thiazol-5-yl)phenyl, 3-(1,3- 5 Oxazol-2-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(1,3-oxazol-2-yl)phenyl, 4-Chlor-3-(1,3- oxazol-2-yl)phenyl, 3-(2-Methyl-1,3-oxazol-5-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(2- methyl-1,3-oxazol-5-yl)phenyl, 4-Chlor-3-(2-methyl-1,3-oxazol-5-yl)phenyl, 3-(2-Oxoazetidin- 1-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(2-oxoazetidin-1-yl)phenyl, 4-Chlor-3-(2- oxoazetidin-1-yl)phenyl, 3-(2-Oxopyrrolidin-1-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(2-10 oxopyrrolidin-1-yl)phenyl, 4-Chlor-3-(2-oxopyrrolidin-1-yl)phenyl, 3-(2,4-Dioxoimidazolidin- 1-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(2,4-dioxoimidazolidin-1-yl)phenyl,4-Chlor-3-(2,4- dioxoimidazolidin-1-yl)phenyl, 3-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-5- (trifluormethoxy)phenyl, 3-Chlor-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)phenyl, 4-Chlor- 3-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)phenyl, 3-(6-Methyl-2,4-dioxo-3,4-15 dihydropyrimidin-1(2H)-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(6-methyl-2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)phenyl, 4-Chlor-3-(6-methyl-2,4-dioxo-3,4-dihydropyrimidin- 1(2H)-yl)phenyl, 4,5-Dichlor-2-hydroxyphenyl, 3,4-Dichlor-5-hydroxyphenyl, 3,4-Dichlor-2- hydroxyphenyl, 1,3-Benzoxathiol-6-yl, 3-Methylcarbonyl-5-nitrophenyl, 4,5-Dichlor-2- fluorphenyl, 3,4-Dichlor-2-fluorphenyl, 3,4-Dichlor-5-fluorphenyl, 2,2-Difluor-1,3-20 benzodioxol-5-yl, 3-(1-Methylcycloprop-1-yl)-5-fluorphenyl, 3-(1-Methylcycloprop-1-yl)-5- chlorphenyl, 3-(1-Methylcycloprop-1-yl)-5-bromphenyl, 3-(1-Methylcycloprop-1-yl)-5- trifluormethylphenyl, 3-(1-Methylcycloprop-1-yl)-5-trifluormethoxyphenyl, 3- (Methylaminocarbonyl)-5-trifluormethoxyphenyl,3-(Ethylaminocarbonyl)-5- trifluormethoxyphenyl, 3-(Prop-2-ylaminocarbonyl)-5-trifluormethoxyphenyl, 3-25 (Cyclopropylaminocarbonyl)-5-trifluormethoxyphenyl, 3-Aminocarbonyl-5- trifluormethoxyphenyl, 3-(Methylaminocarbonyl)-5-trifluormethylphenyl, 3- (Ethylaminocarbonyl)-5-trifluormethylphenyl, 3-(Prop-2-ylaminocarbonyl)-5- trifluormethylphenyl, 3-(Cyclopropylaminocarbonyl)-5-trifluormethylphenyl, 3-Aminocarbonyl- 5-trifluormethylphenyl, 3-(Methylaminocarbonyl)-5-chlorphenyl, 3-(Ethylaminocarbonyl)-5-30 chlorphenyl, 3-(Prop-2-ylaminocarbonyl)-5-chlorphenyl, 3-(Cyclopropylaminocarbonyl)-5- chlorphenyl, 3-Aminocarbonyl-5-chlorphenyl, 3-Methyl-5-phenyl-4,5-dihydro-1,2-oxazol-5-yl, 3-Methyl-4,5-dihydro-1,2-oxazol-5-yl steht, R, 2 für Wasserstoff steht, 35 R 3für Methyl, Ethyl, Prop-1-yl, 1-Methylethyl, But-1-yl, 1-Methylprop-1-yl, 2-Methylprop-1-yl, 1,1-Dimethylethyl, Pent-1-yl, 1-Methylbut-1-yl, 2-Methylbut-1-yl, 3-Methylbut-1-yl, 1,1- BCS241005-Ausland STR 30 Dimethylprop-1-yl, 1,2-Dimethylprop-1-yl, 2,2-Dimethylprop-1-yl, 1-Ethylprop-1-yl, Hex-1-yl, 1-Methylpent-1-yl, 2-Methylpent-1-yl, 3-Methylpent-1-yl, 4-Methylpent-1-yl, 1-Ethylbut-1-yl, 2-Ethylbut-1-yl, 1,2-Dimethylbut-1-yl, 1,3-Dimethylbut-1-yl, 2,2-Dimethylbut-1-yl, 3,3- Dimethylbut-1-yl, Cyclopropyl, Cyclobutyl, Cyclopentyl, Cyclohexyl, Methoxymethyl, 5 Ethoxymethyl, Methoxyethyl, Ethoxyethyl, Cyclopropylmethyl, Cyclobutylmethyl, Cyclopentylmethyl, Cyclohexylmethyl, Vinyl, Prop-1-en-1-yl, Prop-2-en-1-yl, But-1-en-1-yl, But-2-en-1-yl, But-3-en-1-yl, Pent-1-en-1-yl, Pent-2-en-1-yl, Pent-3-en-1-yl, Pent-4-en-1-yl, 1- Methylprop-2-en-1-yl, 2-Methylprop-2-en-1-yl, 1-Methylbut-2-en-1-yl, 2-Methylbut-2-en-1-yl, 3-Methylbut-2-en-1-yl, 1-Methylbut-3-en-1-yl, 2-Methylbut-3-en-1-yl,3-Methylbut-3-en-1-yl, 10 1,1-Dimethylprop-2-en-1-yl, or 1,2-Dimethylprop-2-en-1-yl stands, R, 5 , R 6 stand for hydrogen, R 7 R stands for hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, prop-1-yl, prop-2-yl, cyclopropyl, 15-cyclobutyl, methoxy, ethoxy, trifluoromethoxy, difluoromethoxy, difluoromethyl, trifluoromethyl 17 , R 18 , R 19 and R 20 independently of each other stand for hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, prop-1-yl, prop-2-yl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, methoxy, ethoxy, prop-1-yloxy, prop-2-yloxy, trifluoromethoxy, difluoromethoxy, difluoromethyl, trifluoromethyl, and Q stands for a remainder of the following formulas Q-1 to Q-500. 25 BCS241005-Abroad STR 31 BCS241005-Abroad STR 32 5 BCS241005-Abroad STR 33 5 BCS241005-Abroad STR 34 5 BCS241005-Abroad STR 35 5 BCS241005-Abroad STR 36 5 BCS241005-Abroad STR 37 5 BCS241005-Abroad STR 38 5 BCS241005-Abroad STR 39 5 BCS241005-Abroad STR 40 5 BCS241005-Abroad STR 41 5 BCS241005-Abroad STR 42 5 BCS241005-Abroad STR 43 5 In particular, the preferred subject matter of the invention is compounds of the general formula (I), wherein 10 M for one of the groups BCS241005-Abroad STR 44 M -1 M-2 M-3 stands, where the dashed line marks the point of connection to the rest of formula (I), 5 R 1für 3,4-Dichlorphenyl, 3,5-Dichlorphenyl, 3,4-bis(Trifluormethyl)phenyl, 3,5- bis(Trifluormethyl)phenyl, 3-Trifluormethylphenyl, 4-Trifluormethylphenyl, 3-Chlor-5- trifluormethoxyphenyl, 2-(2,2-Dibromcyclopropyl)phenyl, 3-(1-Cyanocycloprop-1-yl)phenyl, 3- Chlor-5-trifluormethylphenyl, 4-Chlor-3-trifluormethoxyphenyl, 3-Chlor-5-iodphenyl, 3-Fluor-10 5-iodphenyl, 3-Iod-4-chlorphenyl, 3-Brom-4-chlorphenyl, 3-Fluor-5-trifluormethoxyphenyl, 3- Brom-5-trifluormethoxyphenyl, 3-(Prop-2-yl)-5-trifluormethoxyphenyl, 3-[(E)- (Methoxyimino)methyl]-5-trifluormethoxyphenyl, 3-Methyl-5-trifluormethoxyphenyl, 3-Cyano- 5-trifluormethoxyphenyl, 3-Nitrophenyl, 3-Nitro-5-trifluormethylphenyl, 3-(4- Methoxycarbonylphenyl)-5-trifluormethylphenyl, 3-Fluor-5-trifluormethylphenyl, 3-Brom-5-15 trifluormethylphenyl, 3-Trifluormethyl-4-chlorphenyl, 3-Chlor-4-trifluormethylphenyl, 3,4- Diiodphenyl, 3,5-Diiodphenyl, 3-(Methylsulfanyl)-5-(1H-pyrazol-1-yl)phenyl, 4-Chlor-3- nitrophenyl, 3-Chlor-4-nitrophenyl,5-Trifluormethylpyridin-3-yl, 2-Trifluormethylpyridin-4-yl, 5-Fluorpyrazin-2-yl, 6-Brompyridin-3-yl, 2,6-Difluorpyridin-4-yl, 3-Iod-5-trifluormethylphenyl, 3-Methylsulfonyl-5-trifluormethylphenyl, 3,5-bis(Trifluormethoxy)phenyl, 3-Difluormethoxy-5-20 trifluormethylphenyl, 3-Chlor-5-methylsulfonylphenyl, 3-Trifluormethoxyphenyl, 5- Trifluormethoxypyridin-3-yl, 3-Chlor-5-(pentafluor-λ⁶-sulfanyl)phenyl, 3-Fluor-5-(pentafluor- λ⁶-sulfanyl)phenyl, 3-Brom-5-(pentafluor-λ⁶-sulfanyl)phenyl, 3,5-bis(Methylsulfonyl)phenyl, 1,3-benzodithiol-5-yl, 2,3-dihydro-1,4-benzodithiin-6-yl, 2,6-bis(Trifluormethyl)phenyl, 3,4- Dibromphenyl, 3,5-bis(Methylsulfanyl)phenyl, 3,4-bis(Methylsulfanyl)phenyl, 2,3-Dihydro-1,4-25 benzoxathiin-7-yl, 2,3-Dihydro-1,4-benzoxathiin-6-yl, 1,3-Benzoxathiol-5-yl, 1,3-Benzoxathiol- 6-yl, 3-Chlor-5-cyclopropylphenyl, 3-Chlor-5-methoxyphenyl, 3-Brom-5-methoxyphenyl, 3- (1H-pyrazol-1-yl)phenyl, 3-Brom-5-methylsulfonylphenyl, 1,3-Benzodioxol-5-yl, 3-Chlor-5- nitrophenyl,4-Brom-3-methylsulfonylphenyl, 3-Nitro-4-methoxyphenyl, 2-Methylpyrimidin-5- yl, 3-Fluor-4-methylphenyl, 4-Methoxypyridin-2-yl, 5-Methylpyrazin-2-yl, 3,4- 30 bis(Methylsulfonyl)phenyl, 3,3-Dioxido-1,3-benzoxathiol-6-yl, 3-Oxido-1,3-benzoxathiol-6-yl, 4,4-Dioxido-2,3-dihydro-1,4-benzoxathiin-7-yl, 4,4-Dioxido-2,3-dihydro-1,4-benzoxathiin-6-yl, 3,3-Dioxido-1,3-benzoxathiol-5-yl, 1,1,3,3-Tetraoxido-1,3-benzodithiol-5-yl, 3-(4-Chlor-1H- BCS241005-Ausland STR 45 pyrazol-1-yl)phenyl, 3-(4-Brom-1H-pyrazol-1-yl)phenyl, 3-(4-Iod-1H-pyrazol-1-yl)phenyl, 6- Chlor-1,3-benzodioxol-5-yl, 3-Brom-4-methylsulfonylphenyl, 6-Chlorpyridin-3-yl, 1,1,4,4- Tetraoxido-2,3-dihydro-1,4-benzodithiin-6-yl, 1,1,4-Trioxido-2,3-dihydro-1,4-benzodithiin-6-yl, 1,4,4-Trioxido-2,3-dihydro-1,4-benzodithiin-6-yl, 3-Ethylsulfonyl-5-trifluormethoxyphenyl, 6- 5 Fluorpyridin-2-yl, 3,5-Dibromphenyl, 4-(1-Cyanocycloprop-1-yl)phenyl, 5-Brompyridin-3-yl, 3- Brom-4,5-dichlorphenyl, 3,4,5-Trichlorphenyl,3-(1-Cyanocycloprop-1-yl)-5-fluorphenyl, 3-(1- Cyanocycloprop-1-yl)-5-trifluormethoxyphenyl, 1,3-Benzothiazol-6-yl, 3-Chlor-5-cyanophenyl, 3-Methylsulfanyl-5-(1H-1,2,4-triazol-1-yl)phenyl, 2-Methyl-1,3-benzothiazol-5-yl, 2-Chlor-1,3- benzothiazol-5-yl, Naphth-2-yl, 3-Methylsulfonyl-5-(1H-1,2,4-triazol-1-yl)phenyl, 2-Methoxy-10 1,3-benzothiazol-5-yl, 4-Brom-3-chlorphenyl, 6-Bromnaphth-2-yl, 5-Bromnaphth-2-yl, 1,3- Benzothiazol-5-yl, 3-Methylsulfonyl-5-(1H-pyrazol-1-yl)phenyl, 2,3-Dichlorphenyl, 2,4- Dichlorphenyl, 2,5-Dichlorphenyl, 2,4-Dibromphenyl, 3,4-Difluorphenyl, 3,5-Difluorphenyl, 3,4-Dichlor-5-trifluormethoxyphenyl, 3-Iodphenyl, 4-Iodphenyl, 3-Chlor-1,2-thiazol-5-yl, 7- Chlor-1,2-benzothiazol-3-yl, 1,2-Benzoxazol-3-yl, 3,4-Dichlor-1,2-thiazol-5-yl, 4,5-Dichlor-1,2- 15 thiazol-3-yl, 3-Chlor-4-cyano-1,2-thiazol-5-yl, 1-Methyl-1H-pyrazol-5-yl, 5-Chlorthien-3-yl, 2,5-Dichlorthien-3-yl, 4-Methyl-1,2-oxazol-5-yl, 5-Methyl-1,2-oxazol-3-yl, 4-Methyl-1,3- oxazol-5-yl, 4-Methyl-1,2,3-thiadiazol-5-yl, 4-Methyl-1,3-thiazol-2-yl, 4-Chlor-1,3-Dimethyl- 1H-pyrazol-5-yl, 1,3-Thiazol-4-yl, 2-Chlor-1,3-thiazol-4-yl, 2-Chlor-1,3-thiazol-5-yl, 1,3- Thiazol-5-yl, 3-difluormethoxy-5-methylthien-2-yl, 3-Difluormethoxythien-2-yl, 4-Bromthien-20 3-yl, 3,4-Dibromthien-2-yl, 4-Brom-3-methoxythien-2-yl, 4-Brom-3-methylthien-2-yl, 5- Bromthien-2-yl, 4,5-Dichlorthien-2-yl, 5-Chlorthien-2-yl, 5-(1-cyanocycloprop-1-yl)thien-2-yl, 4,5-Dibromthien-2-yl, 3,5-Dimethyl-4,5-dihydro-1,2-oxazol-5-yl, 3-Trifluormethyl-5-methyl- 4,5-dihydro-1,2-oxazol-5-yl, 2,3-Dibromphenyl, 2,5-Dibromphenyl, 4-Brom-3,5-Dichlorphenyl, 2,3-Difluorphenyl, 3-Fluor-4-chlorphenyl, 3-Methylcarbonyl-5-nitrophenyl, 4,5-Dichlor-2-25 fluorphenyl, 3,4-Dichlor-2-fluorphenyl, 3,4-Dichlor-5-fluorphenyl, 2,2-Difluor-1,3- benzodioxol-5-yl, 3-(1-Methylcycloprop-1-yl)-5-trifluormethoxyphenyl, 3- (Methylaminocarbonyl)-5-trifluormethoxyphenyl, 2-{2-Chlor-4-fluor-5-[3-methyl-2,6-dioxo-4- (trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}-1,3-thiazol-5-yl, 3-[2-chloro-5-(3,5-dimethyl-2,6-dioxo-4-sulfanyliden-1,3,5-triazinan-1-yl)-4-fluorophenyl]-5-methyl-4,5-dihydro-30 1,2-oxazol-5-yl, 2-[2-Chloro-5-(3,5-dimethyl-2,6-dioxo-4-sulfanyliden-1,3,5-triazinan-1-yl)-4-fluorophenyl]-1,3-thiazol-5-yl, 3-Methyl-5-phenyl-4,5-dihydro-1,2-oxazol-5-yl, 3-Methyl-4,5- dihydro-1,2-oxazol-5-yl is, R, 2 stands for hydrogen, 35 R 3 BCS241005-Abroad STR 46 R stands for Methyl, Ethyl, Prop-1-yl, 1-Methyleth-1-yl, Cyclopropyl, Cyclobutyl, Vinyl 5 , R 6 stand for hydrogen, R 7 5 R stands for hydrogen, fluorine, chlorine, methyl, methoxy 17 , R 18 , R 19 and R 20The n-values ​​stand independently for hydrogen, fluorine, chlorine, bromine, methyl, and methoxy, and Q stands for one of the residues Q-1, Q-2, Q-23, Q-24, Q-26, Q-71, Q-72, Q-89, Q-91, Q-93, Q-115, Q-152, Q-176, Q-179, Q-286, Q-287, Q-301, Q-302, Q-371, Q-441, Q-442, Q-444, Q-471, Q-472, Q-481, Q-489, Q-490, Q-491, Q-499, and Q-500. The above general or preferred residue definitions apply both to the final products of formula (I) and, accordingly, to the starting materials or intermediates required for their preparation. These residue definitions can be combined arbitrarily with one another, including between the specified preferred regions. 15 With regard to the compounds according to the invention, the designations used above and below are explained.These are familiar to those skilled in the art and have in particular the meanings explained below: 20 Unless otherwise defined, the general rule for the designation of chemical groups is that the connection to the framework or the rest of the molecule takes place via the last mentioned structural element of the chemical group concerned, i.e. for example in the case of (C2-C8)-alkenyloxy via the oxygen atom, and in the case of heterocyclyl-(C1-C8)-alkyl or R. 13 O(O)C-(C1-C8)-alkyl, each via the carbon atom of the alkyl group. In a compound chemical group such as heterocyclyl-25(C1-C8)-alkyl or R 13 In O(O)C-(C1-C8)-Alkyl, the term “alkyl” therefore also stands for an alkylene group. The functional groups are C(=O)R. 13 , C(=O)OR 13 , C(=O)NR 11 R 12 , NR 11 R 12 , OR 13 , S(O) m R 14The connection to the framework or the rest of the molecule occurs via the first-mentioned structural element of the relevant chemical group. According to the invention, "alkylsulfonyl" – either alone or as part of a chemical group – represents straight-chain or branched alkylsulfonyl, preferably with 1 to 8, or with 1 to 6 carbon atoms, e.g.(aber nicht beschränkt auf) (C1-C6)-Alkylsulfonyl wie Methylsulfonyl, Ethyl- sulfonyl, Propylsulfonyl, 1-Methylethylsulfonyl, Butylsulfonyl, 1-Methylpropylsulfonyl, 2-Methyl- propylsulfonyl, 1,1-Dimethylethylsulfonyl, Pentylsulfonyl, 1-Methylbutylsulfonyl, 2-Methylbutyl-35 sulfonyl, 3-Methylbutylsulfonyl, 1,1-Dimethylpropylsulfonyl, 1,2-Dimethylpropylsulfonyl, 2,2-Di- methylpropylsulfonyl, 1-Ethylpropylsulfonyl, Hexylsulfonyl, 1-Methylpentylsulfonyl, 2-Methyl- pentylsulfonyl, 3-Methylpentylsulfonyl, 4-Methylpentylsulfonyl, 1,1-Dimethylbutylsulfonyl, 1,2-Di- BCS241005-Ausland STR 47 methylbutylsulfonyl, 1,3-Dimethylbutylsulfonyl, 2,2-Dimethylbutylsulfonyl, 2,3-Dimethylbutylsulfonyl, 3,3-Dimethylbutylsulfonyl, 1-Ethylbutylsulfonyl, 2-Ethylbutylsulfonyl, 1,1,2-Trimethylpropylsulfonyl, 1,2,2-Trimethylpropylsulfonyl, 1-Ethyl-1-methylpropylsulfonyl und 1-Ethyl-2-methylpropylsulfonyl.5 According to the invention, "heteroarylsulfonyl" means optionally substituted pyridylsulfonyl, pyrimidinylsulfonyl, pyrazinylsulfonyl, or optionally substituted polycyclic heteroarylsulfonyl, in particular optionally substituted quinolinylsulfonyl, for example substituted by fluorine, chlorine, bromine, iodine, cyano, nitro, alkyl, haloalkyl, haloalkoxy, amino, alkylamino, alkylcarbonylamino, dialkylamino, or alkoxy groups. 10 According to the invention, "alkylthio" means—alone or as part of a chemical group—straight-chain or branched S-alkyl, preferably with 1 to 8, or with 1 to 6 carbon atoms, such as (C1-C. 10)-, (C1-C6)- oder (C1-C4)-Alkylthio, z.B. (aber nicht beschränkt auf) (C1- C6)-Alkylthio wie Methylthio, Ethylthio, Propylthio, 1-Methylethylthio, Butylthio, 1-Methylpropylthio,15 2-Methylpropylthio, 1,1-Dimethylethylthio, Pentylthio, 1-Methylbutylthio, 2-Methylbutylthio, 3- Methylbutylthio, 1,1-Dimethylpropylthio, 1,2-Dimethylpropylthio, 2,2-Dimethylpropylthio, 1- Ethylpropylthio, Hexylthio, 1-Methylpentylthio, 2-Methylpentylthio, 3-Methylpentylthio, 4-Methyl- pentylthio, 1,1-Dimethylbutylthio, 1,2-Dimethylbutylthio, 1,3-Dimethylbutylthio, 2,2-Dimethylbutyl- thio, 2,3-Dimethylbutylthio, 3,3-Dimethylbutylthio, 1-Ethylbutylthio, 2-Ethylbutylthio, 1,1,2-Tri-20 methylpropylthio, 1,2,2-Trimethylpropylthio, 1-Ethyl-1-methylpropylthio und 1-Ethyl-2-methyl- propylthio.According to the invention, “alkenylthio” means an alkenyl residue bonded via a sulfur atom, “alkynylthio” means an alkynyl residue bonded via a sulfur atom, “cycloalkylthio” means a cycloalkyl residue bonded via a sulfur atom, and “cycloalkenylthio” means a cycloalkenyl residue bonded via a sulfur atom. Unless otherwise defined elsewhere, “alkylsulfinyl (alkyl-S(=O)-)” refers to alkyl residues bonded to the framework via -S(=O)-, such as (C1-C. 10)-, (C1-C6)- oder (C1-C4)- 30 Alkylsulfinyl, z. B. (aber nicht beschränkt auf) (C1-C6)-Alkylsulfinyl wie Methylsulfinyl, Ethylsulfinyl, Propylsulfinyl, 1-Methylethylsulfinyl, Butylsulfinyl, 1-Methylpropylsulfinyl, 2-Methylpropylsulfinyl, 1,1-Dimethylethylsulfinyl, Pentylsulfinyl, 1-Methylbutylsulfinyl, 2-Methylbutylsulfinyl, 3- Methylbutylsulfinyl, 1,1-Dimethylpropylsulfinyl, 1,2-Dimethylpropylsulfinyl, 2,2-Di- methylpropylsulfinyl, 1-Ethylpropylsulfinyl, Hexylsulfinyl, 1-Methylpentylsulfinyl, 2-Methylpentyl-35 sulfinyl, 3-Methylpentylsulfinyl, 4-Methylpentylsulfinyl, 1,1-Dimethylbutylsulfinyl, 1,2-Dimethyl- butylsulfinyl, 1,3-Dimethylbutylsulfinyl, 2,2-Dimethylbutylsulfinyl, 2,3-Dimethylbutylsulfinyl, 3,3- BCS241005-Ausland STR 48 Dimethylbutylsulfinyl, 1-Ethylbutylsulfinyl, 2-Ethylbutylsulfinyl, 1,1,2-Trimethylpropylsulfinyl, 1,2,2- Trimethylpropylsulfinyl, 1-Ethyl-1-methylpropylsulfinyl und 1-Ethyl-2-methylpropylsulfinyl.Analogously, “alkenylsulfinyl” and “alkynylsulfinyl”, as defined according to the invention, are alkenyl and alkynyl residues respectively, which are bound to the framework via -S(=O)-, such as (C2-C. 10 )-, (C2-C6)- or (C2-C4)- alkenylsulfinyl or (C3-C 10 )-, (C3-C6)- or (C3-C4)-alkynylsulfinyl. Analogously, “alkenylsulfonyl” and “alkynylsulfonyl” are defined according to the invention as alkenyl and alkynyl residues, respectively, which are bonded to the framework via -S(=O)2-, such as (C2-C 10 )-, (C2-C6)- or (C2-C4)- 10 alkenylsulfonyl or (C3-C 10)-, (C3-C6)- or (C3-C4)-alkynylsulfonyl. “Alkoxy” means an alkyl group bonded via an oxygen atom, e.g. B. (but not limited to) (C1-C6) alkoxy such as methoxy, ethoxy, propoxy, 1-methylethoxy, butoxy, 1-methylpropoxy, 2-methylpropoxy, 1,1-dimethylethoxy, pentoxy, 1-methylbutoxy, 2-methylbutoxy, 3-methylbutoxy, 1,1-15 dimethylpropoxy, 1,2-dimethylpropoxy, 2,2-dimethylpropoxy, 1-ethylpropoxy, hexoxy, 1-methylpentoxy, 2-methylpentoxy, 3-methylpentoxy, 4-methylpentoxy, 1,1-dimethylbutoxy, 1,2-dimethylbutoxy, 1,3-dimethylbutoxy, 2,2-dimethylbutoxy, 2,3-dimethylbutoxy, 3,3-dimethylbutoxy, 1-ethylbutoxy, 2-ethylbutoxy, 1,1,2-Trimethylpropoxy, 1,2,2-Trimethylpropoxy, 1-Ethyl-1-methylpropoxy, and 1-Ethyl-2-methylpropoxy. Alkenyloxy means an alkenyl group bonded via an oxygen atom; alkynyloxy means an alkynyl group bonded via an oxygen atom, such as (C2-C 10 )-, (C2-C6)- or (C2-C4)-alkenoxy or (C3-C 10)-, (C3-C6)- or (C3-C4)-alkyneoxy. “Cycloalkyloxy” means a cycloalkyl group bonded via an oxygen atom and cycloalkenyloxy means a cycloalkenyl group bonded via an oxygen atom. 25 “Alkylcarbonyl” (alkyl-C(=O)-), unless otherwise defined elsewhere, according to the invention stands for alkyl groups that are bonded to the framework via -C(=O)-, such as (C1-C 10 )-, (C1-C6)- or (C1-C4)- alkylcarbonyl. The number of carbon atoms refers to the alkyl group in the alkylcarbonyl group. 30 Analogously, unless otherwise defined elsewhere, “alkenylcarbonyl” and “alkynylcarbonyl” are, according to the invention, alkenyl and alkynyl groups, respectively, that are bonded to the framework via -C(=O)-, such as (C2-C 10 )-, (C2-C6)- or (C2-C4)-alkenylcarbonyl or (C2-C 10)-, (C2-C6)- or (C2-C4)- alkynyl carbonyl. The number of carbon atoms refers to the alkenyl or alkynyl residue in the alkenyl or alkynyl carbonyl group. BCS241005-Abroad STR 49 “Alkoxycarbonyl (Alkyl-OC(=O)-)”, unless otherwise defined elsewhere: Alkyl residues that are bonded to the skeleton via -OC(=O)-, such as (C1-C 10 )-, (C1-C6)- or (C1-C4)-alkoxycarbonyl. The number of carbon atoms refers to the alkyl group in the alkoxycarbonyl group. Similarly, unless otherwise defined elsewhere, "alkenyloxycarbonyl" and "alkynyloxycarbonyl" are, according to the invention, alkenyl and alkynyl groups, respectively, that are bonded to the framework via -OC(=O)-, such as (C2-C 10 )-, (C2-C6)- or (C2-C4)-alkenyloxycarbonyl or (C3-C 10)-, (C3-C6)- or (C3-C4)- alkynyloxycarbonyl. The number of carbon atoms refers to the alkenyl or alkynyl residue in the alkene or alkynyloxycarbonyl group, respectively. 10 According to the invention, the term "alkylcarbonyloxy" (alkyl-C(=O)-O-) refers, unless otherwise defined elsewhere, to alkyl residues that are bonded to the skeleton via a carbonyloxy group (-C(=O)-O-) with the oxygen, such as (C1-C 10 )-, (C1-C6)- or (C1-C4)-alkylcarbonyloxy. The number of carbon atoms refers to the alkyl group in the alkylcarbonyloxy group. 15 Analogously, “alkenylcarbonyloxy” and “alkynylcarbonyloxy” are defined according to the invention as alkenyl and alkynyl groups, respectively, which are bonded to the skeleton via (-C(=O)-O-) with the oxygen, such as (C2-C 10 )-, (C2-C6)- or (C2-C4)-alkenylcarbonyloxy or (C2-C 10)-, (C2-C6)- or (C2-C4)-alkynylcarbonyloxy. The number of carbon atoms refers to the alkenyl or alkynyl residue in the alkenyl or alkynylcarbonyloxy group. 20 In short forms such as C(O)R 13 , C(O)OR 13 , OC(O)NR 11 R 12 , or C(O)NR 11 R 12 The abbreviation O shown in parentheses represents an oxygen atom bonded to the adjacent carbon atom via a double bond. 25 In abbreviations such as OC(S)OR 13 , OC(S)SR 14 , OC(S)NR 11 R 12The abbreviation S in parentheses represents a sulfur atom bonded to the adjacent carbon atom via a double bond. The term "aryl" means an optionally substituted mono-, bi-, or polycyclic aromatic system with preferably 6 to 14, in particular 6 to 10, ring carbon atoms, for example phenyl, naphthyl, anthryl, phenanthrenyl, and the like, preferably phenyl or naphthyl, and in particular preferably phenyl. The term "optionally substituted aryl" also includes multicyclic systems such as tetrahydronaphtyl, indenyl, indanyl, fluorenyl, and biphenylyl, where the bonding site is on the aromatic system. From a systematic perspective, "aryl" is generally also encompassed by the term "optionally substituted phenyl." Preferred aryl substituents here are, for example, BCS241005-Ausland STR 50 hydrogen, halogen, alkyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, halocycloalkyl, alkenyl, alkynyl, aryl, arylalkyl, arylalkenyl,Heteroaryl, Heteroarylalkyl, Heterocyclyl, Heterocyclylalkyl, Alkoxyalkyl, Alkylthio, Haloalkylthio, Haloalkyl, Alkoxy, Haloalkoxy, Cycloalkoxy, Cycloalkylalkoxy, Aryloxy, Heteroraryloxy, Alkoxyalkoxy, Alkinylalkoxy, Alkenyloxy, Bis-alkylaminoalkoxy, Tris- 5 [alkyl]silyl, Bis-[alkyl]arylsilyl, Bis-[alkyl]alkylsilyl, Tris-[alkyl]silylalkinyl, Arylalkinyl, Heteroarylalkinyl, Alkylalkinyl, Cycloalkylalkinyl, Haloalkylalkinyl, Heterocyclyl-N-alkoxy, Nitro, Cyano, Amino, Alkylamino, Bis-alkylamino, Alkylcarbonylamino, Cycloalkylcarbonylamino, Arylcarbonylamino, Alkoxycarbonylamino, Alkoxycarbonylalkylamino, Arylalkoxycarbonylalkylamino, Hydroxycarbonyl, Alkoxycarbonyl, Aminocarbonyl, 10 Alkylaminocarbonyl, Cycloalkylaminocarbonyl, Bis-Alkylaminocarbonyl, Heteroarylalkoxy, Arylalkoxy Wenn nicht anders in einem bestimmten Kontext hier definiert, enthält ein „heterocyclischer Rest“ („Heterocyclyl“) mindestens einen heterocyclischen Ring (=carbocyclischer Ring,in which at least one carbon atom is replaced by a heteroatom (preferably a heteroatom from the group N, O, S, P) which is saturated, unsaturated, partially saturated, or heteroaromatic and may be unsubstituted or substituted, wherein the bonding site is located on a ring atom. If the heterocyclyl residue or the heterocyclic ring is optionally substituted, it may be fused to other carbocyclic or heterocyclic rings. In the case of optionally substituted heterocyclyl, multicyclic systems are also included, such as 8-aza-bicyclo[3.2.1]octanyl, 8-aza-bicyclo[2.2.2]octanyl, or 1-aza-bicyclo[2.2.1]heptyl. In the case of optionally substituted heterocyclyl, spirocyclic systems are also included, such as 1-oxa-5-aza-spiro[2.3]hexyl. Unless otherwise defined, the heterocyclic ring preferably contains 3 to 9 ring atoms, in particular 3 to 6 ring atoms, and one or more,25 preferably 1 to 4, in particular 1, 2 or 3 heteroatoms in the heterocyclic ring, preferably from the group N, O, and S, wherein however no two oxygen atoms should be directly adjacent, such as with a heteroatom from the group N, O and S 1- or 2- or 3-pyrrolidinyl, 3,4-dihydro-2H-pyrrole-2- or 3-yl, 2,3-dihydro-1H-pyrrole-1- or 2- or 3- or 4- or 5-yl; 2,5-dihydro-1H-pyrrole-1- or 2- or 3- or 3-yl, 1- or 2- or 3- or 4-piperidinyl; 2,3,4,5- 30 tetrahydropyridin-2- or 3- or 4- or 5-yl or 6-yl; 1,2,3,6-Tetrahydropyridin-1-, 2-, 3-, 4-, 5-, or 6-yl; 1,2,3,4-Tetrahydropyridin-1-, 2-, 3-, 4-, 5-, or 6-yl; 1,4-Dihydropyridin-1-, 2-, 3-, or 4-yl; 2,3-Dihydropyridin-2-, 3-, 4-, 5-, or 6-yl; 2,5-Dihydropyridin-2-, 3-, 4-, 5-, or 6-yl, 1-, 2-, 3-, or 4-azepanyl; 2,3,4,5-Tetrahydro-1H-azepin-1-, 2-, 3-, 4-, 5-, 6-, or 7-yl; 2,3,4,7-Tetrahydro-1H-35 azepin-1- or 2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,6,7-Tetrahydro-1H-azepin-1- or 2- or 3- or 4-yl; 3,4,5,6-Tetrahydro-2H-azepin-2- or 3- or 4- or 5- or 6- or 7-yl; 4,5-Dihydro-1H-azepin-1- or 2- or 3- or 4-yl; 2,5-Dihydro-1H-azepin-1- or -2- or 3- or 4- or BCS241005-Abroad STR 51 5- or 6- or 7-yl; 2,7-Dihydro-1H-azepin-1- or -2- or 3- or 4-yl; 2,3-Dihydro-1H-azepin-1- or -2- or 3- or 4- or 5- or 6- or 7-yl; 3,4-Dihydro-2H-azepin-2- or 3- or 4- or 5- or 6- or 7-yl; 3,6-Dihydro-2H-azepin-2- or 3- or 4- or 5- or 6- or 7-yl; 5,6-Dihydro-2H-azepin-2- or 3- or 4- or 5- or 6- or 7-yl; 4,5-Dihydro-3H-azepine-2-, 3-, 4-, 5-, 6-, or 7-yl; 1H-azepine-1-, 2-, 3-, 4-, 5-, 6-, or 7-yl; 2H-azepine-2-, 3-, 4-, 5-, 6-, or 7-yl; 3H-azepine-2-, 3-, 4-, 5-, 6-, or 7-yl; 4H-azepine-2-, 3-, 4-, 5-, 6-, or 7-yl; 2- or 3-oxolanyl (= 2- or 3-tetrahydrofuranyl); 2,3-dihydrofuran-2-, 3-, 4-, or 5-yl; 2,5-Dihydrofuran-2- or 3-yl, 2- or 3- or 4-oxanyl (= 2- or 3- or 4-tetrahydropyranyl); 3,4-Dihydro-2H-pyran-2- or 3- or 4- or 5- or 6-yl; 3,6-10-Dihydro-2H-pyran-2- or 3- or 4- or 5- or 6-yl; 2H-pyran-2- or 3- or 4- or 5- or 6-yl; 4H-pyran-2- or 3- or 4-yl, 2- or 3- or 4-oxepanyl; 2,3,4,5-Tetrahydrooxepin-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,4,7-Tetrahydrooxepin-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,6,7-Tetrahydrooxepin-2- or 3- or 4-yl; 2,3-Dihydrooxepin-2- or 3- or 4- or 5- or 6- or 7-yl; 4,5-Dihydrooxepin-2-, 3-, or 4-yl; 2,5-Dihydrooxepin-2-, 3-, 4-, 5-, 6-, or 7-yl; 15-Oxepin-2-, 3-, 4-, 5-, 6-, or 7-yl; 2- or 3-Tetrahydrothiophenyl; 2,3-Dihydrothiophen-2-, 3-, 4-, or 5-yl; 2,5-Dihydrothiophen-2- or 3-yl; Tetrahydro-2H-thiopyran-2-, 3-, or 4-yl; 3,4-Dihydro-2H-thiopyran-2-, 3-, 4-, 5-, or 6-yl; 3,6-Dihydro-2H-thiopyran-2-, 3-, 4-, 5-, or 6-yl; 2H-Thiopyran-2-, 3-, 4-, 5-, or 6-yl; 4H-Thiopyran-2-, 3-, or 4-yl. Preferred 3-ring and 4-ring heterocycles are, for example, 1- or 2-aziridinyl, oxiranyl, thiiranyl, 1- or 2- or 3-acetidinyl, 2- or 3-oxetanyl, 2- or 3-thietanyl, 1,3-dioxetan-2-yl. Other examples of “heterocyclyl” are a partially or fully hydrogenated heterocyclic residue with two heteroatoms from the group N, O, and S, such as 1- or 2- or 3- or 4-pyrazolidinyl; 4,5-dihydro-3H-pyrazole-3-, 4-, or 5-yl; 4,5-Dihydro-1H-pyrazole-1-, 3-, 4-, or 5-yl; 2,3-Dihydro-1H-pyrazole-1-, 2-, 3-, 25-, 4-, or 5-yl; 1-, 2-, 3-, or 4-imidazolidinyl; 2,3-Dihydro-1H-imidazol-1-, 2-, 3-, or 4-yl; 2,5-Dihydro-1H-imidazol-1-, 2-, 4-, or 5-yl; 4,5-Dihydro-1H-imidazol-1-, 2-, 4-, or 5-yl; Hexahydropyridazine-1-, 2-, 3-, or 4-yl; 1,2,3,4-Tetrahydropyridazine-1-, 2-, 3-, 4-, 5-, or 6-yl; 1,2,3,6-Tetrahydropyridazine-1-, 2-, 3-, 4-, 5-, or 6-yl; 1,4,5,6-Tetrahydropyridazine-1-, 3-, 4-, 5-, or 6-yl; 3,4,5,6-Tetrahydropyridazine-3-, 3-, 4-, or 5-yl; 4,5-Dihydropyridazine-3- or 4-yl; 3,4-Dihydropyridazine-3-, 4-, 5-, or 6-yl; 3,6-Dihydropyridazine-3- or 4-yl; 1,6-Dihydropyriazine-1-, 3-, 4-, 5-, or 6-yl; Hexahydropyrimidin-1-, 2-, 3-, or 4-yl; 1,4,5,6-Tetrahydropyrimidin-1-, 2-, 4-, 5-, or 6-yl; 1,2,5,6-Tetrahydropyrimidin-1-, 2-, 4-, 5-, or 6-yl; 1,2,3,4-Tetrahydropyrimidin-1-, 2-, 3-, 4-, 5-, or 6-yl; 1,6-Dihydropyrimidin-1-, 2-, 4-, 5-, or 6-yl; 1,2-Dihydropyrimidin-1-, 2-, 4-, 5-, or 6-yl; 2,5-Dihydropyrimidin-2-, 4-, or 5-yl; 4,5-Dihydropyrimidin-4-, 5-, or 6-yl; 1,4-Dihydropyrimidin-1-, 2-, 4-, 5-, or 6-yl; 1-, 2-, or 3-Piperazinyl; 1,2,3,6-Tetrahydropyrazine-1- or 2- or 3- or 5-yl BCS241005-Foreign STR 52 or 6-yl; 1,2,3,4-Tetrahydropyrazine-1- or 2- or 3- or 4- or 5- or 6-yl; 1,2-Dihydropyrazine-1- or 2- or 3- or 5- or 6-yl; 1,4-Dihydropyrazine-1- or 2- or 3-yl; 2,3-Dihydropyrazine-2- or 3- or 5- or 6-yl; 2,5-Dihydropyrazine-2- or 3-yl; 1,3-Dioxolane-2- or 4- or 5-yl; 1,3-Dioxol-2- or 4-yl; 1,3-Dioxane-2-, 4-, or 5-yl; 4H-1,3-Dioxin-2-, 4-, 5-, or 6-yl; 1,4-Dioxane-2-5-, 3-, 5-, or 6-yl; 2,3-Dihydro-1,4-dioxin-2-, 3-, 5-, or 6-yl; 1,4-Dioxin-2- or 3-yl; 1,2-Dithiolane-3- or 4-yl; 3H-1,2-Dithiol-3- or 4- or 5-yl; 1,3-Dithiolan-2- or 4-yl; 1,3-Dithiol-2- or 4-yl; 1,2-Dithian-3- or 4-yl; 3,4-Dihydro-1,2-dithiin-3- or 4- or 5- or 6-yl; 3,6-Dihydro-1,2-dithiin-3- or 4-yl; 1,2-Dithiin-3- or 4-yl; 1,3-Dithian-2- or 4- or 5-yl; 4H-1,3-Dithiin-2- or 4- or 5- or 6-yl; isoxazolidin-2- or 3- or 4- or 5-yl; 2,3-Dihydroisoxazol-2- or 3- or 4- or 5-yl; 2,5-Dihydroisoxazol-2- or 3- or 4- or 5-yl; 4,5-Dihydroisoxazol-3- or 4- or 5-yl; 1,3-Oxazolidin-2- or 3- or 4- or 5-yl; 2,3-Dihydro-1,3-oxazol-2- or 3- or 4- or 5-yl; 2,5-Dihydro-1,3-oxazol-2- or 4- or 5-yl; 4,5-Dihydro-1,3-oxazol-2- or 4- or 5-yl; 1,2-Oxazinan-2- or 3- or 4- or 5-yl; 3,4-Dihydro-2H-1,2-oxazine-2- or 3- or 4- or 5- or 6-yl; 3,6-Dihydro-2H-1,2-oxazine-2- or 3- or 4- or 5- or 6-yl; 5,6-Dihydro-2H-1,2-oxazine-2- or 3- or 4- or 5- or 6-yl; 5,6-Dihydro-4H-1,2-oxazine-3- or 4- or 5- or 6-yl; 2H-1,2-Oxazine-2-, 3-, 4-, 5-, or 6-yl; 6H-1,2-Oxazine-3-, 4-, 5-, or 6-yl; 4H-1,2-Oxazine-3-, 4-, 5-, or 6-yl; 1,3-Oxazinan-2-, 3-, 4-, 5-, or 6-yl; 3,4-Dihydro-2H-1,3-oxazine-2-, 3-, 4-, 5-, or 6-yl; 3,6-Dihydro-2H-1,3-oxazine-2-, 3-, 4-, 5-, or 6-yl; 5,6-Dihydro-2H-1,3-oxazine-2-, 4-, 5-, or 6-yl; 5,6-Dihydro-4H-1,3-oxazine-2-, 4-, 5-, or 6-yl; 2H-1,3-oxazine-2-, 4-, 5-, or 6-yl; 6H-1,3-oxazine-2-, 4-, 5-, or 6-yl; 4H-1,3-oxazine-2-, 4-, 5-, or 6-yl; Morpholine-2-, 3-, or 4-yl; 3,4-Dihydro-2H-1,4-oxazine-2-, 3-, 4-, 5-, or 6-yl; 3,6-Dihydro-2H-1,4-oxazine-2-, 3-, 5-, or 6-yl; 2H-1,4-oxazine-2-, 3-, 5-, or 6-yl; 4H-1,4-oxazine-2- or 3-yl; 1,2-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,4,5-tetrahydro-1,2-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,4,7-tetrahydro-1,2-25 oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,6,7-Tetrahydro-1,2-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,5,6,7-Tetrahydro-1,2-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 4,5,6,7-Tetrahydro-1,2-oxazepine-3- or 4- or 5- or 6- or 7-yl; 2,3-Dihydro-1,2-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,5-Dihydro-1,2-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,7-Dihydro-1,2-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 4,5-Dihydro-1,2-oxazepine-3- or 4- or 5- or 6- or 7-yl; 4,7-Dihydro-1,2-oxazepine-3- or 4- or 5- or 6- or 7-yl; 6,7-Dihydro-1,2-oxazepine-3- or 4- or 5- or 6- or 7-yl; 1,2-Oxazepine-3- or 4- or 5- or 6- or 7-yl; 1,3-Oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,4,5-Tetrahydro-1,3-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,4,7-Tetrahydro-1,3-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,6,7-Tetrahydro-1,3-oxazepine-2- or 3- or 4- or 5- or 6- or 7-35 yl; 2,5,6,7-Tetrahydro-1,3-oxazepine-2- or 4- or 5- or 6- or 7-yl; 4,5,6,7-Tetrahydro-1,3-oxazepine-2- or 4- or 5- or 6- or 7-yl; 2,3-Dihydro-1,3-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,5-Dihydro-1,3-oxazepine-2- or 4- or 5- or 6- or 7-yl; 2,7-Dihydro-1,3-oxazepine- BCS241005-Abroad STR 53 2- or 4- or 5- or 6- or 7-yl; 4,5-Dihydro-1,3-oxazepine-2- or 4- or 5- or 6- or 7-yl; 4,7-Dihydro-1,3-oxazepine-2- or 4- or 5- or 6- or 7-yl; 6,7-Dihydro-1,3-oxazepine-2- or 4- or 5- or 6- or 7-yl; 1,3-Oxazepine-2- or 4- or 5- or 6- or 7-yl; 1,4-Oxazepine-2- or 3- or 5- or 6- or 7-yl; 2,3,4,5-Tetrahydro-1,4-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,4,7-5 Tetrahydro-1,4-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 2,3,6,7-Tetrahydro-1,4-oxazepine-2- or 3- or 5- or 6- or 7-yl; 2,5,6,7-Tetrahydro-1,4-oxazepine-2-, 3-, 5-, 6-, or 7-yl; 4,5,6,7-Tetrahydro-1,4-oxazepine-2-, 3-, 4-, 5-, 6-, or 7-yl; 2,3-Dihydro-1,4-oxazepine-2-, 3-, 5-, 6-, or 7-yl; 2,5-Dihydro-1,4-oxazepine-2-, 3-, 5-, 6-, or 7-yl; 2,7-Dihydro-1,4-oxazepine-2-, 3-, 5-, 6-, or 7-yl; 4,5-Dihydro-1,4-oxazepine-2-, or 10,3-, 4-, 5-, 6-, or 7-yl; 4,7-Dihydro-1,4-oxazepine-2- or 3- or 4- or 5- or 6- or 7-yl; 6,7-Dihydro-1,4-oxazepine-2- or 3- or 5- or 6- or 7-yl; 1,4-Oxazepine-2- or 3- or 5- or 6- or 7-yl; Isothiazolidin-2- or 3- or 4- or 5-yl; 2,3-Dihydroisothiazol-2- or 3- or 4- or 5-yl; 2,5-Dihydroisothiazol-2- or 3- or 4- or 5-yl; 4,5-Dihydroisothiazol-3- or 4- or 5-yl; 1,3-Thiazolidin-2- or 3- or 4- or 5-yl; 2,3-Dihydro-1,3-thiazol-2- or 3- or 4- or 5-yl; 2,5-15-Dihydro-1,3-thiazol-2- or 4- or 5-yl; 4,5-Dihydro-1,3-thiazol-2- or 4- or 5-yl; 1,3-Thiazinan-2-, 3-, 4-, 5-, or 6-yl; 3,4-Dihydro-2H-1,3-thiazine-2-, 3-, 4-, 5-, or 6-yl; 3,6-Dihydro-2H-1,3-thiazine-2-, 3-, 4-, 5-, or 6-yl; 5,6-Dihydro-2H-1,3-thiazine-2-, 4-, 5-, or 6-yl; 5,6-Dihydro-4H-1,3-thiazine-2-, 4-, 5-, or 6-yl; 2H-1,3-thiazine-2-, 4-, 5-, or 6-yl; 6H-1,3-thiazine-2-, 4-, 5-, or 6-yl; 4H-1,3-thiazine-2-, 4-, 5-, or 6-yl. 20 Other examples of “heterocyclyl” are a partially or fully hydrogenated heterocyclic residue with 3 heteroatoms from the group N, O, and S, such as 1,4,2-dioxazolidin-2-, 3-, or 5-yl; 1,4,2-dioxazol-3- or 5-yl; 1,4,2-dioxazinan-2-, 3-, 5-, or 6-yl; 5,6-dihydro-1,4,2-dioxazin-3-, 5-, or 6-yl; 1,4,2-dioxazin-3-, 5-, or 6-yl; 1,4,2-dioxazepane-2-, 3-, 5-, 6-, or 7-yl; 6,7-Dihydro-5H-1,4,2-Dioxazepine-3- or 5- or 6- or 7-yl; 2,3-Dihydro-7H-1,4,2- 25 Dioxazepine-2- or 3- or 5- or 6- or 7-yl; 2,3-Dihydro-5H-1,4,2-dioxazepine-2- or 3- or 5- or 6- or 7-yl; 5H-1,4,2-dioxazepine-3- or 5- or 6- or 7-yl; 7H-1,4,2-dioxazepine-3- or 5- or 6- or 7-yl. Examples of structures for potentially further substituted heterocycles are also listed below: BCS241005-Abroad STR 54 BCS241005-Abroad STR 55 Die oben aufgeführten Heterocyclen sind bevorzugt beispielsweise durch Wasserstoff, Halogen, Alkyl, Haloalkyl, Hydroxy, Alkoxy, Cycloalkoxy, Aryloxy, Alkoxyalkyl, Alkoxyalkoxy, Cycloalkyl, Halocycloalkyl, Aryl, Arylalkyl, Heteroaryl, Heterocyclyl, Alkenyl, Alkylcarbonyl, Cycloalkylcarbonyl, 5 Arylcarbonyl, Heteroarylcarbonyl, Alkoxycarbonyl, Hydroxycarbonyl, Cycloalkoxycarbonyl, Cycloalkylalkoxycarbonyl, Alkoxycarbonylalkyl, Arylalkoxycarbonyl, Arylalkoxycarbonylalkyl, Alkinyl, Alkinylalkyl, Alkylalkinyl, Tris-alkylsilylalkinyl, Nitro, Amino, Cyano, Haloalkoxy, BCS241005-Ausland STR 56 Haloalkylthio, Alkylthio, Hydrothio, Hydroxyalkyl, Oxo, Heteroarylalkoxy, Arylalkoxy, Heterocyclylalkoxy, Heterocyclylalkylthio, Heterocyclyloxy, Heterocyclylthio, Heteroaryloxy, Bis- alkylamino, Alkylamino, Cycloalkylamino, Hydroxycarbonylalkylamino, Alkoxycarbonylalkylamino, Arylalkoxycarbonylalkylamino, Alkoxycarbonylalkyl(alkyl)amino, Aminocarbonyl, 5 Alkylaminocarbonyl, Bis-alkylaminocarbonyl,Cycloalkylaminocarbonyl, hydroxycarbonylalkylaminocarbonyl, alkoxycarbonylalkylaminocarbonyl, arylalkoxycarbonylalkylaminocarbonyl. If a parent compound is substituted "by one or more residues" from an enumeration of residues (= group) 10 or a generically defined group of residues, this includes simultaneous substitution by several identical and / or structurally different residues. If it is a partially or fully saturated nitrogen heterocycle, it can be linked to the rest of the molecule via either carbon or nitrogen. 15 The substituents listed below are suitable for a substituted heterocyclic residue.Additionally, oxo and thioxo are also included. The "oxo group" as a substituent on a ring carbon atom then means, for example, a carbonyl group in the heterocyclic ring. This preferably also includes lactones and lactams. The oxo group can also occur on the 20 heteroring atoms, which can exist in different oxidation states, e.g., at N and S, and then form, for example, the divalent groups N(O)₂, S(O)₂ (also abbreviated SO), and S(O)₂ (also abbreviated SO₂) in the heterocyclic ring. In the case of –N(O)- and –S(O)- groups, both enantiomers are included. 25 According to the invention, the term "heteroaryl" stands for heteroaromatic compounds, i.e., completely unsaturated aromatic heterocyclic compounds, preferably for 5- to 7-membered rings with 1 to 4, preferably 1 or 2 identical or different heteroatoms, preferably O.S oder N. Erfindungsgemäße Heteroaryle sind beispielsweise 1H-Pyrrol-1-yl; 1H-Pyrrol-2-yl; 1H-Pyrrol- 3-yl; Furan-2-yl; Furan-3-yl; Thien-2-yl; Thien-3-yl, 1H-Imidazol-1-yl; 1H-Imidazol-2-yl; 1H-Imidazol-30 4-yl; 1H-Imidazol-5-yl; 1H-Pyrazol-1-yl; 1H-Pyrazol-3-yl; 1H-Pyrazol-4-yl; 1H-Pyrazol-5-yl, 1H-1,2,3- Triazol-1-yl, 1H-1,2,3-Triazol-4-yl, 1H-1,2,3-Triazol-5-yl, 2H-1,2,3-Triazol-2-yl, 2H-1,2,3-Triazol-4-yl, 1H-1,2,4-Triazol-1-yl, 1H-1,2,4-Triazol-3-yl, 4H-1,2,4-Triazol-4-yl, 1,2,4-Oxadiazol-3-yl, 1,2,4- Oxadiazol-5-yl, 1,3,4-Oxadiazol-2-yl, 1,2,3-Oxadiazol-4-yl, 1,2,3-Oxadiazol-5-yl, 1,2,5-Oxadiazol-3-yl, Azepinyl, Pyridin-2-yl, Pyridin-3-yl, Pyridin-4-yl, Pyrazin-2-yl, Pyrazin-3-yl, Pyrimidin-2-yl, 35 Pyrimidin-4-yl, Pyrimidin-5-yl, Pyridazin-3-yl, Pyridazin-4-yl, 1,3,5-Triazin-2-yl, 1,2,4-Triazin-3-yl, 1,2,4-Triazin-5-yl, 1,2,4-Triazin-6-yl, 1,2,3-Triazin-4-yl, 1,2,3-Triazin-5-yl, 1,2,4-, 1,3,2-, 1,3,6- und 1,2,6-Oxazinyl, Isoxazol-3-yl, Isoxazol-4-yl, Isoxazol-5-yl, 1,3-oxazol-2-yl, 1,3-oxazol-4-yl, 1,3- BCS241005-Ausland STR 57 Oxazol-5-yl, isothiazol-3-yl, isothiazol-4-yl, isothiazol-5-yl, 1,3-thiazol-2-yl, 1,3-thiazol-4-yl, 1,3-thiazol-5-yl, Oxepinyl, Thiepinyl, 1,2,4-triazolonyl and 1,2,4-diazepinyl, 2H-1,2,3,4-tetrazol-5-yl, 1H-1,2,3,4-tetrazol-5-yl, 1,2,3,4-oxatriazol-5-yl, 1,2,3,4-thiatriazol-5-yl, 1,2,3,5-Oxatriazol-4-yl, 1,2,3,5-Thiatriazol-4-yl. The heteroaryl groups according to the invention can further be substituted with one or more identical or different substituents. If two adjacent carbon atoms are part of another aromatic ring, the resulting heteroaromatic systems are fused, such as benzo-condensed or multiply fused heteroaromatics. For example, quinolines (e.g., quinoline-2-yl, quinoline-3-yl, quinoline-4-yl, quinoline-5-yl, quinoline-6-yl, quinoline-7-yl, quinoline-8-yl) and isoquinolines (e.g., isoquinoline-1-yl, isoquinoline-3-yl, isoquinoline-4-yl, isoquinoline-5-yl) are preferred.Isochinolin-6-yl, Isochinolin-7-yl, Isochinolin-8-yl); Chinoxalin; Chinazolin; Cinnolin; 1,5-Naphthyridin; 1,6-Naphthyridin; 1,7-Naphthyridin; 1,8-Naphthyridin; 2,6- Naphthyridin; 2,7-Naphthyridin; Phthalazin; Pyridopyrazine; Pyridopyrimidine; Pyridopyridazine; Pteridine; Pyrimidopyrimidine. Beispiele für Heteroaryl sind auch 5- oder 6-gliedrige benzokondensierte Ringe aus der Gruppe 1H-Indol-1-yl, 1H-Indol-2-yl, 1H-Indol-3-yl, 1H-Indol-4-yl, 1H-Indol-5-yl, 1H-15 Indol-6-yl, 1H-Indol-7-yl, 1-Benzofuran-2-yl, 1-Benzofuran-3-yl, 1-Benzofuran-4-yl, 1-Benzofuran-5- yl, 1-Benzofuran-6-yl, 1-Benzofuran-7-yl, 1-Benzothiophen-2-yl, 1-Benzothiophen-3-yl, 1- Benzothiophen-4-yl, 1-Benzothiophen-5-yl, 1-Benzothiophen-6-yl, 1-Benzothiophen-7-yl, 1H-Indazol- 1-yl, 1H-Indazol-3-yl, 1H-Indazol-4-yl, 1H-Indazol-5-yl, 1H-Indazol-6-yl, 1H-Indazol-7-yl, 2H-Indazol- 2-yl, 2H-Indazol-3-yl, 2H-Indazol-4-yl, 2H-Indazol-5-yl, 2H-Indazol-6-yl, 2H-Indazol-7-yl, 2H- 20 Isoindol-2-yl, 2H-Isoindol-1-yl,2H-isoindol-3-yl, 2H-isoindol-4-yl, 2H-isoindol-5-yl, 2H-isoindol-6-yl; 2H-Isoindol-7-yl, 1H-Benzimidazol-1-yl, 1H-Benzimidazol-2-yl, 1H-Benzimidazol-4-yl, 1H-Benzimidazol-5-yl, 1H-Benzimidazol-6-yl, 1H-Benzimidazol-7-yl, 1,3-Benzoxazol-2-yl, 1,3- Benzoxazol-4-yl, 1,3-Benzoxazol-5-yl, 1,3-Benzoxazol-6-yl, 1,3-Benzoxazol-7-yl, 1,3-Benzthiazol-2-yl, 1,3-Benzthiazol-4-yl, 1,3-Benzthiazol-5-yl, 1,3-Benzthiazol-6-yl, 1,3-Benzthiazol-7-yl, 1,2-25 benzisoxazol-3-yl, 1,2-Benzisoxazol-4-yl, 1,2-Benzisoxazol-5-yl, 1,2-Benzisoxazol-6-yl, 1,2-Benzisoxazol-7-yl, 1,2-Benzisothiazol-3-yl, 1,2-Benzisothiazol-4-yl, 1,2-Benzisothiazol-5-yl, 1,2-Benzisothiazol-6-yl, 1,2-Benzisothiazol-7-yl. The term "halogen" means, for example, fluorine, chlorine, bromine, or iodine. If the designation is used for a residue, then "halogen" means, for example, a fluorine, chlorine, bromine, or iodine atom. According to the invention, "alkyl" means a straight-chain or branched open-chain,a saturated hydrocarbon residue, which may be singly or multiply substituted and in the latter case is referred to as 35 “substituted alkyl”. Preferred substituents are halogen atoms, alkoxy, haloalkoxy, cyano, alkylthio, haloalkylthio, amino, or nitro groups; methoxy, methyl, fluoroalkyl, cyano, nitro, fluorine, chlorine, bromine, or iodine are particularly preferred. The prefix “bis” also includes combinations of different alkyl residues, e.g., methyl(ethyl) or ethyl(methyl). Depending on the notation used, alkyl residues may have different names for the same group, which are, however, commonly used in the field. For example, the names 1-methyleth-1-yl, 1-methylethyl, prop-2-yl, and iso-propyl are synonymous. 5. “Haloalkyl”, “-alkenyl” and “-alkynyl” mean alkyl, alkenyl and alkynyl respectively, which are partially or completely substituted by the same or different halogen atoms.zB Monohaloalkyl (= Monohalogenalkyl) such as CH2CH2Cl, CH2CH2Br, CHClCH3, CH2Cl, CH2F; Perhaloalkyl such as CCl, 3, CClF 2, CFCl2,CF2CClF 2,CF2CClFCF3; Polyhaloalkyl such as CH2CHFCl, CF2CClFH, CF2CBrFH, CH2CF3; The term perhaloalkyl also includes the term perfluoroalkyl. "Haloalkoxy" is, for example, OCF3, OCHF2, OCH2F, OCF2CF3, OCH2CF3, and OCH2CH2Cl; The same applies to haloalkenyl and other halogen-substituted residues. 15 The expression "(C1-C4)-alkyl" mentioned here as an example is a shorthand notation for straight-chain or branched alkyl with one to four carbon atoms, corresponding to the range specified for carbon atoms, i.e., it includes the residues methyl, ethyl, 1-propyl, 2-propyl, 1-butyl, 2-butyl, 2-methylpropyl, or tert-butyl. General alkyl groups with a larger specified range of carbon atoms, e.g., "(C1-C6)-alkyl", also include straight-chain or branched alkyl groups with a larger number of carbon atoms, i.e., as in the example, also the alkyl groups with 5 and 6 carbon atoms. Unless specifically stated, the hydrocarbon groups such as alkyl, alkenyl, and alkynyl groups are also included.Even in compound residues, the lower carbon skeletons, e.g., with 1 to 6 carbon atoms or, in the case of unsaturated groups, with 2 to 6 carbon atoms, are preferred. Alkyl residues, also in compound residues such as alkoxy, haloalkyl, etc., mean, for example, methyl, ethyl, n- or i-propyl, n-, i-, t- or 2-butyl, pentyls, hexyls such as n-hexyl, i-hexyl, and 1,3-dimethylbutyl, heptyls such as n-heptyl, 1-methylhexyl, and 1,4-dimethylpentyl; alkenyl and alkynyl residues have the meaning of possible unsaturated residues corresponding to the alkyl residues, containing at least one double bond or triple bond, respectively. Residues with one double bond or triple bond are preferred. The term “alkenyl” includes in particular straight-chain or branched open-chain hydrocarbon residues with more than one double bond, such as 1,3-butadienyl and 1,4-pentadienyl, 35 but also allenyl or cumulenyl residues with one or more cumulated double bonds,wie beispielsweise Allenyl (1,2-Propadienyl), 1,2-Butadienyl und 1,2,3-Pentatrienyl. Alkenyl bedeutet z.B. Vinyl, welches ggf. durch weitere Alkylreste substituiert sein kann, z B. (aber nicht beschränkt auf) BCS241005-Ausland STR 59 (C2-C6)-Alkenyl wie Ethenyl, 1-Propenyl, 2-Propenyl, 1-Methylethenyl, 1-Butenyl, 2-Butenyl, 3- Butenyl, 1-Methyl-1-propenyl, 2-Methyl-1-propenyl, 1-Methyl-2-propenyl, 2-Methyl-2-propenyl, 1- Pentenyl, 2-Pentenyl, 3-Pentenyl, 4-Pentenyl, 1-Methyl-1-butenyl, 2-Methyl-1-butenyl, 3-Methyl-1- butenyl, 1-Methyl-2-butenyl, 2-Methyl-2-butenyl, 3-Methyl-2-butenyl, 1-Methyl-3-butenyl, 2-Methyl-3- 5 butenyl, 3-Methyl-3-butenyl, 1,1-Dimethyl-2-propenyl, 1,2-Dimethyl-1-propenyl, 1,2-Dimethyl-2- propenyl, 1-Ethyl-1-propenyl, 1-Ethyl-2-propenyl, 1-Hexenyl, 2-Hexenyl, 3-Hexenyl, 4-Hexenyl, 5- Hexenyl, 1-Methyl-1-pentenyl, 2-Methyl-1-pentenyl, 3-Methyl-1-pentenyl, 4-Methyl-1-pentenyl, 1- Methyl-2-pentenyl, 2-Methyl-2-pentenyl, 3-Methyl-2-pentenyl, 4-Methyl-2-pentenyl,1-Methyl-3-pentenyl, 2-Methyl-3-pentenyl, 3-Methyl-3-pentenyl, 4-Methyl-3-pentenyl, 1-Methyl-4-pentenyl, 2-10 Methyl-4-pentenyl, 3-Methyl-4-pentenyl, 4-Methyl-4-pentenyl, 1,1-Dimethyl-2-butenyl, 1,1-Dimethyl-3-butenyl, 1,2-Dimethyl-1-butenyl, 1,2-Dimethyl-2-butenyl, 1,2-Dimethyl-3-butenyl, 1,3-Dimethyl-1-butenyl, 1,3-Dimethyl-2-butenyl, 1,3-Dimethyl-3-butenyl, 2,2-Dimethyl-3-butenyl, 2,3-Dimethyl-1-butenyl, 2,3-Dimethyl-2-butenyl, 2,3-Dimethyl-3-butenyl, 3,3-Dimethyl-1-butenyl, 3,3-Dimethyl-2-butenyl, 1-Ethyl-1-butenyl, 1-Ethyl-2-butenyl, 1-Ethyl-3-butenyl, 2-Ethyl-1-butenyl, 2-Ethyl-2-butenyl, 1,1,2-Trimethyl-2-propenyl, 1-Ethyl-1-methyl-2-propenyl, 1-Ethyl-2-methyl-1-propenyl, and 1-Ethyl-2-methyl-2-propenyl. The term "alkynyl" also includes, in particular, straight-chain or branched open-chain hydrocarbon residues with more than one triple bond, or with one or more triple bonds and one or more double bonds.wie beispielsweise 1,3-Butatrienyl bzw.3-Penten-1-in-1-yl. (C2-C6)-Alkinyl bedeutet z.B. Ethinyl, 1-Propinyl, 2-Propinyl, 1-Butinyl, 2- Butinyl, 3-Butinyl, 1-Methyl-2-propinyl, 1-Pentinyl, 2-Pentinyl, 3-Pentinyl, 4-Pentinyl, 1-Methyl-2- butinyl, 1-Methyl-3-butinyl, 2-Methyl-3-butinyl, 3-Methyl-1-butinyl, 1,1-Dimethyl-2-propinyl, 1-Ethyl- 2-propinyl, 1-Hexinyl, 2-Hexinyl, 3-Hexinyl, 4-Hexinyl, 5-Hexinyl, 1-Methyl-2-pentinyl, 1-Methyl-3-25 pentinyl, 1-Methyl-4-pentinyl, 2-Methyl-3-pentinyl, 2-Methyl-4-pentinyl, 3-Methyl-1-pentinyl, 3- Methyl-4-pentinyl, 4-Methyl-1-pentinyl, 4-Methyl-2-pentinyl, 1,1-Di-methyl-2-butinyl, 1,1-Dimethyl-3- butinyl, 1,2-Dimethyl-3-butinyl, 2,2-Dimethyl-3-butinyl, 3,3-Dimethyl-1-butinyl, 1-Ethyl-2-butinyl, 1- Ethyl-3-butinyl, 2-Ethyl-3-butinyl und 1-Ethyl-1-methyl-2-propinyl. 30 Der Begriff „Cycloalkyl“ bedeutet ein carbocyclisches, gesättigtes Ringsystem mit vorzugsweise 3-8 Ring-C-Atomen, z.B. Cyclopropyl, Cyclobutyl, Cyclopentyl oder Cyclohexyl,which may be further substituted, preferably by hydrogen, alkyl, alkoxy, oxo, cyano, nitro, alkylthio, haloalkylthio, halogen, alkenyl, alkynyl, haloalkyl, amino, alkylamino, bisalkylamino, alkoxycarbonyl, hydroxycarbonyl, arylalkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, 35 cycloalkylaminocarbonyl. In the case of optionally substituted cycloalkyl, cyclic systems with substituents are included, wherein substituents with a double bond on the cycloalkyl group, e.g. an alkylidene group such as methylidene, are also included. In the case of BCS241005-Ausland STR 60 possibly substituted cycloalkyl, multicyclic aliphatic systems are also included, such as bicyclo[1.1.0]butan-1-yl, bicyclo[1.1.0]butan-2-yl, bicyclo[2.1.0]pentan-1-yl, bicyclo[1.1.1]pentan-1-yl, bicyclo[2.1.0]pentan-2-yl, bicyclo[2.1.0]pentan-5-yl, bicyclo[2.1.1]hexyl, bicyclo[2.2.1]hept-2-yl, bicyclo[2.2.2]octan-2-yl, bicyclo[3.2.1]octan-2-yl, bicyclo[3.2.2]nonan-2-yl,Adamantan-1-yl and 5 adamantan-2-yl, but also systems such as 1,1'-bi(cyclopropyl)-1-yl, 1,1'-bi(cyclopropyl)-2-yl. The term "(C3-C7)-cycloalkyl" is a shorthand notation for cycloalkyls with three to seven carbon atoms, corresponding to the range specified for the number of carbon atoms. In the case of substituted cycloalkyls, spirocyclic aliphatic systems are also included, such as 10 spiro[2.2]pent-1-yl, spiro[2.3]hex-1-yl, spiro[2.3]hex-4-yl, 3-spiro[2.3]hex-5-yl, spiro[3.3]hept-1-yl, and spiro[3.3]hept-2-yl. “Cycloalkenyl” means a carbocyclic, non-aromatic, partially unsaturated ring system with preferably 4-8 carbon atoms, e.g., 1-cyclobutenyl, 2-cyclobutenyl, 1-cyclopentenyl, 2-cyclopentenyl, 15, 3-cyclopentenyl, or 1-cyclohexenyl, 2-cyclohexenyl, 3-cyclohexenyl, 1,3-cyclohexadienyl, or 1,4-cyclohexadienyl, wherein substituents with a double bond on the cycloalkenyl group, e.g., an alkylidene group such as methylidene, are also possible.are included. In the case of possibly substituted cycloalkenyl, the explanations for substituted cycloalkyl apply accordingly. 20 The term “alkylidene”, e.g. also in the form (C1-C, 10 )-Alkylidene refers to the residue of a straight-chain or branched open-chain hydrocarbon group linked by a double bond. Naturally, only positions on the parent compound where two hydrogen atoms can be replaced by the double bond are suitable for alkylidene bonding sites; examples include =CH₂, =CH-CH₃, =C(CH₃)-CH₃, =C(CH₃)-C₂H₅, or =C(C₂H₅)-C₂H₅. 5.Cycloalkylidene means a 25 carbocyclic group bonded via a double bond. "Cycloalkylalkyloxy" means a cycloalkylalkyl group bonded via an oxygen atom, and "arylalkyloxy" means an arylalkyl group bonded via an oxygen atom. "Alkoxyalkyl" stands for an alkoxy group bonded via an alkyl group, and "alkoxyalkoxy" means an alkoxyalkyl group bonded via an oxygen atom, e.g., (but not limited to) methoxymethoxy, methoxyethoxy, ethoxyethoxy, methoxy-n-propyloxy. "Alkylthioalkyl" stands for an alkyl thio group bonded via an alkyl group, and "alkylthioalkylthio" means an alkyl thioalkyl group bonded via an oxygen atom. BCS241005-Abroad STR 61 “Arylalkoxyalkyl” stands for an aryloxy residue bound via an alkyl group and “Heteroaryloxyalkyl” means a heteroaryloxy residue bound via an alkyl group.“Haloalkoxyalkyl” refers to a bonded haloalkoxy group, and “haloalkylthioalkyl” means a haloalkylthiogroup bonded via an alkyl group. “Arylalkyl” refers to an aryl group bonded via an alkyl group, “heteroarylalkyl” means a heteroaryl group bonded via an alkyl group, and “heterocyclylalkyl” means a heterocyclyl group bonded via an alkyl group. “Cycloalkylalkyl” refers to a cycloalkyl group bonded via an alkyl group, e.g. (but not limited to) cyclopropylmethyl, cyclobutylmethyl, cyclopentylmethyl, cyclohexylmethyl, 1-cyclopropyleth-1-yl, 2-cyclopropyleth-1-yl, 1-cyclopropylprop-1-yl, 3-cyclopropylprop-1-yl. 15 “Arylalkenyl” stands for an aryl residue bound via an alkenyl group, “Heteroarylalkenyl” means a heteroaryl residue bound via an alkenyl group, and “Heterocyclylalkenyl” means a heterocyclyl residue bound via an alkenyl group.“Arylalkynyl” stands for an aryl residue bound via an alkynyl group, “Heteroarylalkynyl” 20 means a heteroaryl residue bound via an alkynyl group, and “Heterocyclylalkynyl” means a heterocyclyl residue bound via an alkynyl group. According to the invention, "haloalkylthio" – either alone or as part of a chemical group – represents straight-chain or branched S-haloalkyl, preferably with 1 to 8, or with 1 to 6 carbon atoms, such as (C1-C8), (C1-C6) or (C1-C4)-haloalkylthio, e.g. (but not limited to) trifluoromethylthio or trifluoromethylsulfanyl, pentafluoroethylthio or pentafluoroethylsulfanyl, difluoromethyl, 2,2-difluoroeth-1-ylthio, 2,2,2-difluoroeth-1-ylthio, 3,3,3-prop-1-ylthio. "Halocycloalkyl" and "halocycloalkenyl" are distinguished by the presence of the same or different halogen atoms, such as F, Cl and Br, or by the presence of haloalkyl, such as...Trifluoromethyl or difluoromethyl partially or fully substituted cycloalkyl or cycloalkenyl, e.g., 1-fluorocycloprop-1-yl, 2-fluorocycloprop-1-yl, 2,2-difluorocycloprop-1-yl, 1-fluorocyclobut-1-yl, 1-trifluoromethylcycloprop-1-yl, 2-trifluoromethylcycloprop-1-yl, 1-chlorocycloprop-1-yl, 2-chlorocycloprop-1-yl, 2,2-dichlorocycloprop-1-yl, 3,3-difluorocyclobutyl. According to the invention, "trialkylsilyl" or "tris(alkyl)silyl"—whether used alone or as part of a chemical group—represents straight-chain or branched silicon alkyl, preferably with 1 to 8 carbon atoms, or BCS241005-Ausland STR 62 with 1 to 6 carbon atoms, such as Tri-[(C1-C8), (C1-C6) or (C1-C4)-alkyl]silyl, for example (but not limited to) trimethylsilyl, triethylsilyl, tri-(n-propyl)silyl, tri-(isopropyl)silyl, tri-(n-butyl)silyl, tri-(1-methylprop-1-yl)silyl, tri-(2-methylprop-1-yl)silyl, Tri(1,1-Dimethyleth-1-yl)silyl, Tri(2,2-Dimethyleth-1-yl)silyl.5 “Trialkylsilylalkynyl” represents a trialkylsilyl residue bound via an alkynyl group. Synthesis of substituted arylpyrazines of general formula (I): 10 The synthesis of the compounds according to the invention is described below. A central intermediate is represented by compounds of formula (VII), the synthesis of which is described in detail in WO 2021 / 069575 and illustrated in Scheme 1. The substituent X is shown here. 1 in compounds of formula (II) for chlorine, bromine, or iodine. Compounds of formula (II) are commercially available or can be synthesized by methods well known in the literature. Upon metallation15 of (II) in the ortho position to X 1 A compound is obtained with intermediate (III) that is in ortho position to X 1The intermediate (III) contains a metal fragment M' consisting of a metal such as lithium, magnesium, or zinc, as well as suitable ligands (e.g., 2,2,6,6-tetramethylpiperidide). Subsequently, the intermediate (III) is reacted with an aldehyde (IV). In the resulting alcohol (V), the hydroxyl group is substituted by a protected amine, yielding the intermediate of formula 20 (VII). The substituents PG 1 and PG 2 These are amine protecting groups, which can either exist separately or together with the nitrogen atom of the amine, forming a ring. Depending on the reaction method, one or the other type of protecting group is chosen. It is also possible that one of the residues is PG. 1 or PG 2 for hydrogen. Details of the synthesis of compounds of formula (VII) presented here are given in 25 WO 2021 / 069575. Scheme 1: 30. An alternative approach to the intermediates (VII) involves, for example, the oxidation of the alcohol (V) to the ketone (VIII), followed by reductive amination to the intermediate (IX). This can be protected with suitable protecting groups at BCS241005-Ausland STR 63 amine, and here too the amine protecting groups PG 1 and PG 2 They may be separate from each other or may form a ring together with the nitrogen atom of the amine. Furthermore, one of the PG residues may be 1 or PG 2 For hydrogen (Scheme 2). Depending on the conversion method, one or the other variant of the 5 protecting groups is chosen. Scheme 2: 10 Cross-coupling reactions are useful for incorporating the residues M-1, M-2, and M-3, in which the intermediates (VII) are reacted with such reaction partners of formulas (X-1), (X-2), and (X-3) that, according to the definitions of residues M-1, M-2, and M-3, bear a substituted aryl ring (Scheme 3). In the case of substituent X 2 These are substituents typical for cross-coupling reactions, such as a trialkylstannyl group, a boronic acid, or a boronic ester, or a metal fragment consisting of a metal such as zinc, nickel, or magnesium and suitable ligands. Cross-coupling reactions are typically catalyzed by transition metal catalysts such as palladium or copper with suitable ligands such as phosphines or N-heterocyclic carbenes. Alternatively, the cross-coupling reaction can also be carried out such that the roles of X 1 and X 2are swapped. In this case 20, the cross-coupling reaction would involve substituent X. 1 For example, it could be a trialkylstannyl group, a boronic acid or a boronic acid ester, or a metal fragment consisting of a metal such as zinc, nickel, or magnesium and suitable ligands – whereby this functionality may need to be produced beforehand, for example, from the corresponding halide. Accordingly, substituent X would be 2The leaving group may consist of chlorine, bromine, iodine, or a suitable sulfonate. Cross-coupling reactions of pyrazines are described, for example, in WO 2021069575. Cross-coupling reactions of pyrazines with aryl derivatives are also known in the literature, for example, by W. Verboom et al. in Org. Biomol. Chem., 2013, 11, 3583. In the next step, the amine is deprotected and then acylated. If necessary, the nitrogen atom of the amide group is then further derivatized. The steps of amine deprotection, amine acylation, and amide derivatization are also described, for example, in WO 2021069575. Scheme 3: BCS241005-Ausland STR 64 BCS241005-Abroad STR 65 The esterification to introduce the groups Q-1 to Q-480 and Q-482 to Q-500 defined above can be carried out, as illustrated by way of example but not as a limitation in Scheme 4, starting from the acid function Q-481 in the respective compound of general formula (I), using suitable coupling reagents (e.g. HOBt = 1-hydroxybenzotriazole, EDC = 1-ethyl-3-(3-5-dimethylaminopropyl)carbodiimide, HATU = O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate, T3P = 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphorinane-2,4,6-trioxide) and suitable bases (e.g. diisopropylethylamine, triethylamine) in a suitable Solvents (e.g. dichloromethane, chloroform, acetonitrile) are used.Alternatively, esterification can be carried out via transformation of group Q-481 in the respective compound of general formula (I) to the acid chloride (XIII-1), (XIII-2) or (XIII-3), for example using thionyl chloride and subsequent reaction with the corresponding alcohol, using a suitable solvent [e.g. dichloromethane (DCM), chloroform, N,N-dimethylacetamide (DMA) or N,N-dimethylformamide (DMF)]. 15 Scheme 4:. ( XIII-1) BCS241005-Abroad STR 66 (XIII-3) In one or more reaction steps of the syntheses shown in Schemes 3 and 4, the residue 5 Q may need to be adjusted, since otherwise undesired reactions may occur at residue Q, or because residue Q in certain forms interferes with a desired reaction at another position in the molecule. If necessary, it is advantageous to convert a form Q suitable for the reactions directly or indirectly into the desired form Q at the end of the synthesis sequence. BCS241005-Ausland STR 67 Selected detailed synthesis examples for compounds of the invention of general formula (I) are listed below. The example numbers given correspond to the numberings given in Tables I.1 to I.3 below. 1 H-NMR-, 13 C-NMR and 19 F-NMR spectroscopic data given for the 5 chemical examples described in the following sections, (400 or 600 MHz at 1H-NMR and 150 MHz at 13 C-NMR and 375 MHz at 19¹⁹F NMR, solvent CDCl3, CD3OD, or d⁶-DMSO, internal standard: tetramethylsilane (δ = 0.00 ppm), were obtained using a Bruker instrument, and the signals indicated have the following meanings: br = broad; s = singlet, d = doublet, t = triplet, dd = double doublet, ddd = doublet of a double doublet, m = multiplet, q = 10 quartet, quint = quintet, sext = sextet, sept = septet, dq = double quartet, dt = double triplet. For diastereomeric mixtures, either the significant signals of both diastereomers or the characteristic signal of the main diastereomer are given. The abbreviations used for chemical groups have, for example, the following meanings: Me = CH3, Et or Ethyl = CH2CH3, t-Hex = C(CH3)2CH(CH3)2, t-Bu = C(CH3)3, n-Bu = unbranched butyl, n-Pr or Prop-1-yl = unbranched propyl, i-Pr or Prop-2-yl = branched propyl, c-Pr = cyclopropyl, c-Bu = cyclobutyl, c-Hex = cyclohexyl.Synthesebeispiele: 20 Nr. I.1-35: (rac)-Methyl-4-(3-{1-[3-chlor-5-(trifluormethoxy)benzamido]ethyl}pyrazin-2-yl)benzoat Synthesestufe 1: 1-(3-Brompyrazin-2-yl)ethanon. Diisopropylamine (73.2 g, 723 mmol, 102 mL, 2.30 equivalents) was dissolved in THF (350 mL) at -78 °C under an argon atmosphere of 25. n-BuLi (2.50 M, 277 mL, 2.20 equivalents) was slowly added dropwise to the solution at -78 °C. The reaction mixture was then warmed to -30 °C and stirred for 30 minutes at this temperature. The mixture was then cooled back to -78 °C. Bromopyrazine (50.0 g, 315 mmol, 1.00 equivalent), dissolved in THF (300 mL), was added dropwise to the mixture over 30 minutes at -78 °C. N-Methoxy-N-methylacetamide (48.7 g, 472 mmol, 30.50.2). mL (1.50 eq.) was then slowly added dropwise to the reaction mixture at -78 °C. The reaction mixture was stirred for 1 hour at -70 °C. Thin-layer chromatography showed that 2-bromopyrazine was completely consumed and a new spot had formed.The reaction mixture was poured into a mixture of ice and a saturated NH4Cl solution (1000 ml), and the aqueous phase was extracted three times with ethyl acetate (300 ml each). The combined organic phases were washed with a saturated saline solution (300 ml), dried with anhydrous Na2SO4, filtered, and concentrated under vacuum. The residue was purified by column chromatography (SiO2, petroleum ether / ethyl acetate = 10:1 to 3:1). 1-(3-Bromopyrazin-2-yl)ethanone (35.0 g, 174 mmol, 55.4% yield) was obtained as a yellow solid. 1 H NMR (400 5 MHz, CDCl3) δ in ppm: 8.69 - 8.53 (m, 1H), 8.47 (d, J = 2.2 Hz, 1H), 2.84 - 2.56 (m, 3H). Synthesis step 2: Methyl 4-(3-acetylpyrazin-2-yl)benzoate A solution of 1-(3-bromopyrazin-2-yl)ethanone (66.2 g, 329 mmol, 1.00 equivalent) in dioxane (330 10 mL) and water (66 mL) was treated under a nitrogen atmosphere with K3PO4 (139 g, 658 mmol, 2.00 equivalent), [4-(methoxycarbonyl)phenyl]boronic acid (65.2 g, 362 mmol, 1.10 equivalent), and Pd(dppf)Cl2 (24.1 g, 32.9 mmol, 0.100 equivalent). The reaction mixture was stirred for 16 hours at 100 °C. TLC (petroleum ether:ethyl acetate = 5:1, Rf = 0.25) showed that 1-(3-bromopyrazin-2-yl)ethanone was completely consumed and a new spot had formed. Reaction mixture 15 was diluted with 200 ml of water and extracted three times with ethyl acetate (200 ml each). The combined organic phases were washed with a saturated sodium chloride solution (200 ml), dried over Na₂SO₄, filtered, and concentrated under reduced pressure. The residue was purified by column chromatography (SiO₂, petroleum ether / ethyl acetate = 10:1 to 4:1).Methyl 4-(3-acetylpyrazin-2-yl)benzoate (75.0 g, 292 mmol, 88.8% yield) was obtained as a yellow solid. 20. 1 H NMR (400 MHz, CDCl3) δ in ppm: 8.76 (br s, 1H), 8.61 (br s, 1H), 8.23 ​​- 8.02 (m, 2H), 7.75 - 7.54 (m, 2H), 3.95 (s, 3H), 2.70 (d, J = 1.5 Hz, 3H). Synthesis step 3: (rac)-methyl 4-[3-(1-aminoethyl)pyrazin-2-yl]benzoate 25. To a solution of (rac)-methyl-4-(3-acetylpyrazin-2-yl)benzoate (70.0 g, 273 mmol, 1.00 eq.) and NH4OAc (126 g, 1.64 mol, 6.00 eq.) in MeOH (350 ml) stirred at 20 °C for 1 hour at 20 °C, NaBH3CN (68.6 g, 1.09 mol, 4.00 equivalents) in NH3^H2O (117 ml) was added. The mixture was stirred at 55 °C for 16 hours. The reaction solution was concentrated under reduced pressure. (rac)-Methyl-4-[3-(1-aminoethyl)pyrazin-2-yl]benzoate (75.0 g, crude) was obtained as a yellow oil (75.0 g, crude) and used in the next synthesis step without further purification. Synthesis step 4: (rac)-Methyl-4-(3-{1-[(tert-butoxycarbonyl)amino]ethyl}pyrazin-2-yl)benzoate 5 Triethylamine (55.0 g, 544 mmol, 75.7 ml, 2.00 eq.) and then Boc₂O (71.2 g, 326 mmol, 75.0 ml, 1.20 eq.) were added dropwise to a solution of methyl 4-[3-(1-aminoethyl)pyrazin-2-yl]benzoate (70.0 g, 272 mmol, 1.00 eq.) in THF (350 ml). The mixture was stirred for 16 hours at 20 °C. The reaction mixture was then diluted with 200 ml of water and extracted three times with ethyl acetate (200 ml each). The combined organic phases were washed with saturated sodium chloride (200 ml), dried over Na₂SO₄, filtered, and concentrated under reduced pressure. The residue was purified by column chromatography (SiO2, petroleum ether / ethyl acetate = 5:1 to 0:1). (rac)-Methyl-4-(3-{1-[(tert-butoxycarbonyl)amino]ethyl}pyrazin-2-yl)benzoate (45.0 g, 125 mmol, 46.2% yield) was obtained as a yellow solid. 1H NMR (400 MHz, CDCl3) δ in ppm: 8.83 - 8.47 (m, 15 2H), 8.19 (d, J = 8.1 Hz, 2H), 7.71 (br d, J = 7.8 Hz, 2H), 5.77 - 5.46 (m, 1H), 5.32 - 5.00 (m, 1H), 3.97 (s, 3H), 1.57 - 1.35 (m, 9H), 1.29 (br d, J = 6.1 Hz, 3H). Synthesestufe 5: (rac)-Methyl-4-[3-(1-aminoethyl)pyrazin-2-yl]benzoathydrochlorid 20. To a solution of (rac)-methyl-4-(3-{1-[(tert-butoxycarbonyl)amino]ethyl}pyrazin-2-yl)benzoate (42.1 g, 118 mmol, 1.00 eq.) in DCM (200 ml), HCl / dioxane (4 M, 421 ml, 1.00 eq.) was added. The crude product was triturated with ethyl acetate for 0.5 hours at 25 °C. (rac)-methyl-4-[3-(1-aminoethyl)pyrazin-2-yl]benzoate hydrochloride (33.3 g, 96.3% yield) was obtained as a cream-colored solid. BCS241005-Ausland STR 70 1H NMR (400 MHz, DMSO-d6) δ in ppm: 8.87-8.77 (m, 2H), 8.69-8.42 (m, 3H), 8.14 (d, J = 8.1 Hz, 2H), 7.78 (d, J = 8.1 Hz, 2H), 4.58-4.48 (m, 1H), 3.91 (s, 3H), 1.42 (d, J = 6.6 Hz, 3H). Synthesis step 6: No. I.1-35, (rac)-methyl-4-(3-{1-[3-chloro-5-5(trifluoromethoxy)benzamido]ethyl}pyrazin-2-yl)benzoate To a stirred suspension of (rac)-methyl-4-[3-(1-aminoethyl)pyrazin-2-yl]benzoate hydrochloride (0.78 g, 2.66 mmol) in dichloromethane (20 mL) 3-chloro-5-(trifluoromethoxy)benzoic acid (703 mg, 2.92 mmol) was added, followed by 1-ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride (611 mg, 3.19 mmol) and 1-hydroxybenzotriazole hydrate (430 mg, 14 wt% H₂O, 2.74 mmol). Triethylamine (1.11 mL, 7.97 mmol) was added, whereupon the reaction mixture became homogeneous. The reaction mixture was stirred overnight at room temperature. A saturated aqueous sodium bicarbonate solution was then added to the reaction mixture, the resulting phases were separated, and the aqueous phase was extracted once with dichloromethane.The combined organic phases 15 were concentrated under vacuum and the resulting crude product was purified by chromatography over silica gel using a gradient of heptane and 0–75% ethyl acetate to give (rac)-methyl-4-(3-{1-[3-chloro-5-(trifluoromethoxy)benzamido]ethyl}pyrazin-2-yl)benzoate (1.11 g, >99% purity, 87% yield) in the form of a white solid. 1 H NMR (400 MHz, DMSO-d6) δ in ppm: 9.15 (d, J = 6.5 Hz, 1H), 8.70–8.66 (m, 2H), 8.08–8.05 (m, 2H), 7.92–7.92 (m, 1H), 7.80–7.79 20 (m, 2H), 7.75–7.74 (m, 1H), 7.69–7.68 (m, 1H), 5.34–5.28 (m, 1H), 3.89 (s, 3H), 1.47 (d, J = 6.8 Hz, 3H). No. I.1-36: (rac)-4-(3-{1-[3-chloro-5-(trifluoromethoxy)benzamido]ethyl}pyrazin-2-yl)benzoic acid BCS241005-Ausland STR 71 A stirred solution of (rac)-methyl-4-(3-{1-[3-chloro-5-(trifluoromethoxy)benzamido]-ethyl}pyrazin-2-yl)benzoate (0.43 g, 0.90 mmol) in THF (8 ml) and water (4 ml) was treated with LiOH (64 mg, 2.67 mmol) and the reaction mixture was stirred overnight at room temperature. The reaction was then acidified to a pH of 1 to 2 with an aqueous 2 M hydrochloric acid solution and extracted with ethyl acetate. The organic extract was washed with saline solution, dried over anhydrous sodium sulfate, filtered and concentrated under vacuum to give the (rac)-4-(3-{1- [3-Chloro-5-(trifluoromethoxy)benzamido]ethyl}pyrazin-2-yl)benzoic acid (0.41 g, >99 % purity, 98 % yield) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ in ppm: 13.10 (brs, 1H), 10 9.18 (d, J = 6.7 Hz, 1H), 8.69–8.66 (m, 2H), 8.07–8.04 (m, 2H), 7.95–7.94 (m, 1H), 7.79–7.74 (m, 3H), 7.72–7.71 (m, 1H), 5.35–5.28 (m, 1H), 1.47 (d, J = 7.0 Hz, 3H). Nr. I.1-42: (rac)-Pyridin-2-ylmethyl-4-(3-{1-[3,5-bis(trifluormethyl)benzamido]ethyl}pyrazin-2- yl)benzoat 15 A solution of 2,2,6,6-tetramethylpiperidine (1.50 eq) in absolute tetrahydrofuran (1 mL / mmol) was cooled to -78 °C under an argon atmosphere and treated dropwise with a solution of n-butyllithium in absolute hexane (2.5 M, 1.30 eq). The resulting reaction mixture was stirred for 30 minutes at -30 °C, cooled again to -78 °C, and treated dropwise with a solution of 2-bromopyrazine (1.00 eq) in absolute tetrahydrofuran (0.5 mL / mmol). The resulting reaction mixture was then stirred for 30 minutes at -78 °C, after which a solution of acetaldehyde (2.00 eq) in absolute tetrahydrofuran (0.5 mL / mmol) was added dropwise. Tetrahydrofuran (0.5 mL / mmol), and the resulting reaction mixture was stirred for 60 minutes at a temperature of -78 °C.After complete conversion (thin-layer chromatography and LC-MS control), the reaction mixture was treated with aqueous NH4Cl solution and thoroughly extracted several times with EtOAc. The combined organic phases were washed with saturated NaCl solution, dried over Na2SO4, filtered, and concentrated under reduced pressure. The remaining residue was purified by column chromatography (SiO2, petroleum ether / ethyl acetate = 5:1 to 20:1), and 1-(3-bromopyrazin-2-yl)ethanol was obtained as a dark yellow oil. 1-(3-bromopyrazin-2-yl)ethanol (1.00 eq) was extracted in abs. Tetrahydrofuran (1.5 mL / mmol) was dissolved, mixed with isoindoline-1,3-dione (1.00 eq) and triphenylphosphine (1.50 eq), stirred for 10 minutes at room temperature, and cooled to 0 °C. Then, 10 mg / ml of diisopropyl azodicarboxylic acid ester (1.50 eq) was added.After complete conversion upon heating to room temperature (reaction monitored by thin-layer chromatography), the reaction mixture was filtered and concentrated under reduced pressure. Column chromatographic purification of the remaining residue (SiO₂, gradient hexane / ethyl acetate) yielded 2-[3-(1-hydroxyethyl)pyrazin-2-yl]-1H-isoindole-1,3(2H)-dione as a colorless solid. In the next step, 2-15[3-(1-hydroxyethyl)pyrazin-2-yl]-1H-isoindole-1,3(2H)-dione (1.00 eq) was dissolved in absolute MeOH and, at room temperature, hydrazine hydrate (5.00 eq) was added dropwise. The resulting reaction mixture was stirred under reflux conditions for 1 h, and after complete conversion (reaction control by LC-MS), the reaction mixture was carefully concentrated under reduced pressure and dissolved in a 1:1 mixture of tetrahydrofuran and H₂O without further purification. Na₂CO₃ (3.00 eq) and Boc₂O (5.00 eq) were then dissolved.00 eq) was added and the resulting reaction mixture was stirred for 12 h at room temperature. After complete conversion (reaction control by LC-MS), the reaction mixture was thoroughly extracted with EtOAc (100 mL x 3), washed with aqueous NaCl solution (100 mL), dried over Na₂SO₄, filtered, and concentrated under reduced pressure. Column chromatographic purification of the remaining residue (SiO₂, petroleum ether / ethyl acetate = 5:1 to 20:1) yielded tert-butyl-[1-(3-bromopyrazin-2-yl)ethyl]carbamate as a colorless solid. A solution of methyl 4-bromobenzoate (1.00 eq) was dissolved in a heated round-bottom flask under argon in absolutes. Dioxane was dissolved and mixed with hexamethyldistannan (1.00 eq) and Pd(PPh3)4 (1 equiv). The resulting reaction mixture was stirred for 12 h at a temperature of 90 °C and, after cooling to room temperature, filtered through Celite for 30 minutes, washed with ethyl acetate, and concentrated under reduced pressure.Methyl 4-(trimethylstannyl)benzoate was obtained as a slightly yellowish, viscous oil by column chromatographic purification of the remaining residue (SiO2, gradient heptane / ethyl acetate). tert-Butyl-[1-(3-bromopyrazin-2-yl)ethyl]carbamate (1.00 eq) was dissolved in absolute toluene in a heated round-bottom flask under argon and treated with methyl 4-(trimethylstannyl)benzoate (1.00 eq) and Pd(PPh3)4 (0.40 eq). The resulting reaction mixture was stirred under reflux conditions with argon for 14 h. The reaction progress was checked by LCMS, and after complete conversion of the starting materials, the reaction mixture was cooled to room temperature, extracted with EtOAc (100 mL x 3), washed with aqueous NaCl solution (100 mL), dried over Na2SO4, filtered and concentrated under reduced pressure.By column chromatographic purification of the remaining residue (SiO2, gradient n-heptane / ethyl acetate), methyl 4-(3-{1-[(tert-butoxycarbonyl)amino]ethyl}pyrazin-2-yl)benzoate was obtained as a pale yellow solid. Methyl 4-(3-{1-[(tert-butoxycarbonyl)amino]ethyl}pyrazin-2-yl)benzoate (1.00 eq) was then dissolved in HCl / dioxane and dichloromethane and stirred for 12 h at room temperature. The reaction mixture was then concentrated under reduced pressure, and the remaining residue of ethyl acetate (50.0 mL) was recrystallized. In this way, methyl 4-[3-(1-aminoethyl)pyrazin-2-yl]benzoate was obtained in the form of a yellowish solid (86% of theory). Methyl 4-[3-(1-aminoethyl)pyrazin-2-yl]benzoate can also exist in the form of its HCl salt and be used as such in subsequent steps, where it can be released by the base used, e.g., triethylamine. Methyl 4-[3-(1-aminoethyl)pyrazin-2-yl]benzoate (2000 mg, 7.77 mmol, 1.00 eq) was dissolved under argon in a heated round-bottom flask in absolute dichloromethane (50 mL) and, after stirring for 5 minutes at room temperature, treated with triethylamine 15 (2.71 mL, 19.40 mmol, 3.0 eq), 3,5-bis(trifluoromethyl)benzoic acid (2006 mg, 7.77 mmol, 1.00 eq), and 50% propanephosphonic anhydride in tetrahydrofuran (5.78 mL, 9.71 mmol, 1.5 eq). The resulting reaction mixture was stirred for 14 h at room temperature, then treated with dichloromethane and washed with dilute HCl (1 M). The organic phase was dried over sodium sulfate, filtered, and concentrated under reduced pressure. By 20 column chromatographic purification of the crude product (gradient heptane / ethyl acetate), methyl 4-(3-{1-[3,5-bis(trifluoromethyl)benzamido]ethyl}pyrazin-2-yl)benzoate (I.1-1) was obtained as a colorless solid (1240 mg, 32% of theory). In the next step, methyl 4-(3-{1-[3,5-bis(trifluoromethyl)benzamido]ethyl}pyrazin-2-yl)benzoate (1200 mg, 2.41 mmol, 1.00 eq) in a mixture of tetrahydrofuran and water (1:1) and treated with sodium hydroxide solution (4M, 9.65 mmol, 4.00 eq). The resulting reaction mixture was then stirred overnight at room temperature, concentrated under reduced pressure, acidified with dilute HCl (10%), and treated with ethyl acetate. The aqueous phase was thoroughly extracted with ethyl acetate, and the combined organic phases were dried over magnesium sulfate, filtered, and concentrated under reduced pressure. Column chromatographic purification of the crude product (gradient heptane / ethyl acetate) yielded 4-(3-{1-30[3,5-Bis(trifluoromethyl)benzamido]ethyl}pyrazin-2-yl)benzoic acid (I.1-2) as a colorless solid (1000 mg, 86% of theory). 4-(3-{1-[3,5-Bis(trifluoromethyl)benzamido]ethyl}pyrazin-2-yl)benzoic acid (120 mg, 0.24 mmol, 1.0 eq), 1-hydroxybenzotriazole (42 mg, 0.31 mmol, 1.3 eq), and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (60 mg, 0.31 mmol, 1.3 eq) were also obtained.3 eq) were dissolved in absolute dichloromethane (5 mL) and, after stirring for 535 minutes at room temperature, treated with triethylamine (0.10 mL, 0.72 mmol, 3.0 equiv) and 2-hydroxymethylpyridine (0.06 mL, 0.31 mmol, 1.3 eq). The resulting reaction mixture was stirred for 6 h at room temperature, then treated with water and dichloromethane and thoroughly extracted using BCS241005-Ausland STR 74. The combined organic phases were dried over magnesium sulfate, filtered, and concentrated under reduced pressure. By column chromatographic purification of the crude product (gradient heptane / ethyl acetate) (rac)-pyridin-2-ylmethyl-4-(3-{1-[3,5- bis(trifluoromethyl)benzamido]ethyl}pyrazin-2-yl)benzoate (I.1-42) was obtained in the form of a colorless solid 5 (87 mg, 59% of theory). 1H-NMR (400 MHz, CDCl3): Peakpicking δ= 8.6652 (8.1); 8.6469 (4.1); 8.6371 (4.2); 8.6090 (7.5); 8.3224 (7.8); 8.3029 (8.6); 8.2499 (14.7); 8.0154 (6.8); 7.7731 (9.9); 7.7533 (11.3); 7.5039 (4.6); 7.4830 (4.7); 7.4538 (2.7); 7.2874 (2.5); 7.2626 (19.9); 5.7156 (2.1); 5.6973 (3.2); 5.6803 (2.1); 5.5829 (0.8); 5.5430 (13.0); 5.5074 (0.8); 5.2997 (5.1); 4.1463 (0.6); 4.1305 (1.5); 4.1132 (1.5); 4.0947 (0.5); 2.1192 (0.6); 2.0450 (6.4); 1.6096 (16.0); 1.4543 (12.6); 1.4374 (12.8); 10 1.2772 (2.5); 1.2592 (5.6); 1.2415 (2.2); 0.8799 (1.0); -0.0002 (20.2). Nr. I.1-81: (+)-Pyridin-2-ylmethyl-4-(3-{1-[3,5-bis(trifluormethyl)benzamido]ethyl}pyrazin-2- yl)benzoat und Nr. I.1-82: (-)-Pyridin-2-ylmethyl-4-(3-{1-[3,5-bis(trifluormethyl)benzamido]ethyl}- pyrazin-2-yl)benzoat 15 The esterification of (I.1-2) described above was repeated on an enlarged scale (1.54 mmol). The resulting racemic pyridin-2-ylmethyl-4-(3-{1-[3,5-20 bis(trifluoromethyl)benzamido]ethyl}pyrazin-2-yl)benzoate (I.1-42) (400 mg) was then separated into its enantiomers using a chiral preparative SFC system with an S10 chiralpak IF-B1 column (gradient Chir_C4_IF_B1_90CO2_MeOH_CD). I.1-81 (Ent-1, 135 mg, retention time 1.41 min, specific rotation +123.30°) and I.1-82 (Ent-2, 145 mg, retention time 1.48 min, specific rotation -115.30°) were isolated as colorless solids. I.1-81: 1 H-NMR 25 (400 MHz, CDCl3): ^ 8.68 (s, 1H). 8.67-8.64 (m, 1H), 8.62 (s, 1H), 8.33-8.30 (d, 2H), 8.25 (s, 2H), 8.02 (s, 1H), 7.79-7.75 (m, 3H), 7.52-7.50 (d, 1H), 7.47-7.45 (d, 1H), 7.30-7.27 (m, 1H), 5.73-5.66 (quint, 1H), 5.59-5.55 (d, 1H), 5.56-5.52 (d, 1H), 1.46-1.44 (d, 3H). I.1-82: 1H-NMR (400 MHz, CDCl3): ^ 8.69 (s, 1H). 8.67-8.64 (m, 1H), 8.63 (s, 1H), 8.32-8.30 (d, 2H), 8.25 (s, 2H), 8.02 (s, 1H), 7.80-7.75 (m, 3H), BCS241005-Ausland STR 75 7.52-7.50 (d, 1H), 7.47-7.45 (d, 1H), 7.30-7.27 (m, 1H), 5.73-5.66 (quint, 1H), 5.59-5.55 (d, 1H), 5.56- 5.52 (d, 1H), 1.46-1.44 (d, 3H). Nr. I.1-68: (rac)-Methyl-4-{3-[1-(3,4-dichlorbenzamido)ethyl]pyrazin-2-yl}benzoat 5 10 Methyl 4-[3-(1-aminoethyl)pyrazin-2-yl]benzoate (200 mg, 0.78 mmol, 1.00 eq) was reacted with triethylamine (0.33 mL, 2.33 mmol, 3.0 eq) in absolute dichloromethane (3 mL) at room temperature. The reaction mixture was then cooled to a temperature of 0–5 °C. A solution of 3,4-dichlorobenzoyl chloride (171 mg, 0.82 mmol, 1.05 eq) in a small amount of dichloromethane was then added dropwise over five minutes. The resulting reaction mixture was stirred at room temperature for 16 h. For work-up, the reaction mixture was concentrated under reduced pressure. By column chromatographic purification20 of the crude product (gradient heptane / ethyl acetate) (rac)-methyl-4-{3-[1-(3,4-dichlorobenzamido)ethyl]pyrazin-2-yl}benzoate (I.1-68) was obtained (212 mg, 63% of theory). 1H-NMR (400.6 MHz, CDCl3): δ= 8.6450 (2.7); 8.6390 (3.2); 8.5909 (3.0); 8.5849 (2.4); 8.2296 (3.6); 8.2086 (3.9); 7.9060 (2.8); 7.9009 (2.8); 7.7410 (3.9); 7.7201 (3.6); 7.6504 (1.3); 7.6453 (1.2); 7.6296 (1.8); 7.6245 (1.7); 7.5309 (3.1); 7.5102 (2.2); 7.3202 (0.8); 7.3014 (0.8); 7.2619 (8.5); 5.6706 (0.9); 25 5.6533 (1.1); 5.6346 (0.8); 3.9722 (16.0); 1.6082 (0.6); 1.4085 (6.2); 1.3918 (6.1); -0.0002 (9.7) No. I.1-66: (rac)-4-{3-[1-(3,4-dichlorobenzamido)ethyl]pyrazin-2-yl}benzoic acid 30 35 BCS241005-Abroad STR 76 Methyl 4-{3-[1-(3,4-dichlorobenzamido)ethyl]pyrazin-2-yl}benzoate (I.1-68) (1.36 g, 3.16 mmol, 1.00 eq) was reacted with sodium hydroxide solution (5.00 mL, 20 wt%, 31.6 mmol, 10.0 eq) in methanol (50 mL). The reaction mixture was then stirred for 1 h at a temperature of 60 °C. For work-up, the reaction mixture was concentrated under reduced pressure. The residue was dissolved in a small amount of water for 5 h, and the mixture was then acidified with 6 N hydrochloric acid. The precipitated solid was separated and dried. For further purification, the solid was stirred with n-heptane, and after filtration, the solid was dried. (rac)-4-{3-[1-(3,4-Dichlorobenzamido)ethyl]pyrazin-2-yl}benzoic acid (I.1-66) was obtained (1.21 g, 92% of theory). 1H-NMR (400.6 MHz, d6-DMSO): δ = 9.0810 (3.5); 9.0645 (3.6); 8.6659 (7.5); 8.6598 (13.6); 8.646610 (16.0); 8.6406 (9.2); 8.0710 (9.7); 8.0660 (9.7); 8.0489 (11.0); 8.0444 (3.5); 8.0325 (3.9); 8.0278 (13.0); 8.0238 (1.9); 7.9569 (0.5); 7.9523 (0.6); 7.7942 (4.5); 7.7891 (4.0); 7.7833 (0.5); 7.7733 (7.2); 7.7681 (7.3); 7.7581 (0.7); 7.7453 (10.5); 7.7408 (3.5); 7.7288 (3.5); 7.7244 (9.4); 7.7157 (13.2); 7.6948 (7.8); 5.3296 (2.4); 5.3127 (3.6); 5.2958 (2.3); 3.3327 (2.6); 3.1689 (0.6); 2.6758 (1.0); 2.6711 (1.5); 2.6666 (1.0); 2.6620 (0.5); 2.5417 (3.7); 2.5376 (0.7); 2.5327 (1.1); 2.5249 (4.5); 2.5202 (6.1); 2.5115 (80.2); 15 2.5069 (173.8); 2.5023 (241.9); 2.4978 (165.0); 2.4932 (71.4); 2.3340 (1.0); 2.3294 (1.4); 2.3247 (1.0); 1.4550 (14.1); 1.4378 (14.0); 0.1456 (0.6); 0.0080 (5.5); 0.0062 (1.4); -0.0002 (200.7); -0.0051 (1.7); - 0.0060 (1.4); -0.0069 (1.3); -0.0085 (5.4); -0.1493 (0.6). Nr. I.1-169: (rac)-2-Methoxyethyl-4-{3-[1-(3,4-dichlorbenzamido)ethyl]pyrazin-2-yl}benzoat 20 25. 4-{3-[1-(3,4-Dichlorobenzamido)ethyl]pyrazin-2-yl}benzoic acid (I.1-66) (200 mg, 0.48 mmol, 1.00 eq) was reacted in dichloromethane (20 mL) with 1-hydroxybenzotriazole (84.4 mg, 0.625 mmol, 1.30 eq), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (120 mg, 0.625 mmol, 1.30 eq), and 4-30-dimethylaminopyridine (0.587 mg, 0.005 mmol, 0.01 eq). Subsequently, 2-methoxyethanol (51.2 mg, 0.673 mmol, 1.40 eq) was added. The reaction mixture was then stirred at room temperature for 16 h. For work-up, the mixture was stirred with water, and after phase separation, the organic phase was concentrated under reduced pressure. Due to incomplete reaction, no pure product could be isolated after column chromatographic purification of the crude product. To complete the reaction, the mixture obtained after column chromatographic purification was reacted in dichloromethane (20 mL) with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (120 mg, 0.625 mmol, 1.30 eq) and triethylamine (97.2 BCS241005-Ausland STR 77 mg, 0.961 mmol, 2.00 eq). Subsequently, 2-methoxyethanol (51.2 mg, 0.673 mmol, 1.40 eq) was added. The reaction mixture was then stirred for 16 h at room temperature. For work-up, the reaction mixture was stirred with water, and after phase separation, the organic phase was dehydrated under reduced pressure. By column chromatographic purification of the crude product (gradient heptane / ethyl acetate), (rac)-2-methoxyethyl-4-{3-[1-(3,4-dichlorobenzamido)ethyl]pyrazin-2-yl}benzoate (I.1-169) was obtained (108 mg, 47% of theory). 1H-NMR(400.6 MHz, CDCl3): δ= 8.6457 (1.0); 8.6396 (1.3); 8.5899 (1.1); 8.5838 (0.9); 8.2588 (1.2); 8.2376 (1.5); 7.9074 (1.0); 7.9023 (1.1); 7.7420 (1.3); 7.7208 (1.3); 7.6301 (0.7); 7.6249 (0.7); 7.5326 (1.2); 7.5119 (0.9); 7.2606 (24.5); 4.5384 (0.6); 4.5294 (0.7); 4.5244 (0.7); 4.5151 10 (0.6); 3.7754 (0.9); 3.7635 (1.0); 3.7518 (0.9); 3.4588 (7.8); 2.0455 (0.6); 1.5475 (16.0); 1.4014 (2.1); 1.3847 (2.2); 0.0079 (0.9); -0.0002 (29.0); -0.0085 (1.0). Nr. I.1-177: (rac)-Isopropyl-4-{3-[1-(3,4-dichlorbenzamido)ethyl]pyrazin-2-yl}benzoat 15 20 4-{3-[1-(3,4-Dichlorobenzamido)ethyl]pyrazin-2-yl}benzoic acid (I.1-66) (150 mg, 0.36 mmol, 1.00 eq) was reacted with 1-hydroxybenzotriazole (63.3 mg, 0.468 mmol, 1.30 eq) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (89.8 mg, 0.468 mmol, 1.30 eq) in dichloromethane (20 mL). The reaction mixture was then stirred for 15 minutes at room temperature. Subsequently, 25 doses of 2-propanol (30.3 mg, 0.504 mmol, 1.40 eq) and triethylamine (72.9 mg, 0.721 mmol, 2.00 eq) were added successively. The reaction mixture was then stirred for 16 h at room temperature. To complete the reaction, 2-propanol (30.3 mg, 0.504 mmol, 1.40 eq) and triethylamine (72.9 mg, 0.721 mmol, 2.00 eq) were added again, and the mixture was stirred once more for 16 h at room temperature. Since the analytical reaction control still did not show complete conversion, 2-propanol (30.3 mg, 0.504 mmol, 1.40 eq) and triethylamine (72.9 mg, 0.721 mmol, 2.00 eq) were added again.The contents were then stirred under reflux for 1 hour and subsequently for five days at room temperature. For work-up, the mixture was stirred with water, and after phase separation, the organic phase was concentrated under reduced pressure. Following column chromatographic purification of the crude product (heptane / ethyl acetate gradient), the residue was dissolved in acetone, and the mixture was then concentrated again under reduced pressure to dryness. (rac)-Isopropyl-4-{3-[1-(3,4-dichlorobenzamido)ethyl]pyrazin-2-yl}benzoate (I.1-177) was obtained (107 mg, 65% of theory). 1H- BCS241005-Ausland STR 78 NMR(400.6 MHz, CDCl3): δ= 8.6478 (2.4); 8.6419 (2.9); 8.5873 (2.7); 8.5815 (2.4); 8.2266 (3.3); 8.2061 (3.8); 7.9079 (2.5); 7.9033 (2.8); 7.7268 (3.6); 7.7062 (3.5); 7.6515 (1.2); 7.6467 (1.2); 7.6308 (1.6); 7.6259 (1.7); 7.5309 (2.7); 7.5102 (2.0); 7.3166 (1.0); 7.2974 (1.0); 7.2610 (12.4); 5.6756 (0.8); 5.6565 (1.2); 5.6390 (0.9); 5.3179 (1.0); 5.3022 (1.3); 5.2866 (1.0); 2.0454 (1.5); 1.5942 (2.4); 1.4152 5 (14.3); 1.3997 (16.0); 1.3881 (6.7); 1.3029 (1.0); 1.2634 (4.7); 1.2420 (1.2); 0.8972 (1.9); 0.8818 (4.7); 0.8641 (2.2); -0.0002 (17.8). Nr. I.1-284: Methyl-4-(3-{[3,5-bis(trifluormethyl)benzamido](cyclopropyl)methyl}pyrazin-2-yl)benzoat 10 Synthesestufe 1: (3-Brompyrazin-2-yl)(cyclopropyl)methanol A solution of N-isopropylpropan-2-amine (58.6 g, 579 mmol, 82 mL, 2.30 eq) in absolute tetrahydrofuran (280 mL) was cooled to -78 °C under an argon atmosphere and treated dropwise with a solution of n-butyllithium in absolute tetrahydrofuran (2.5 M, 221 mL, 2.20 eq). The resulting reaction mixture was stirred for 30 minutes at -30 °C, cooled again to -78 °C, and treated dropwise with a solution of 2-bromopyrazine (40.0 g, 252 mmol, 1.00 eq) in absolute tetrahydrofuran (120 mL). The resulting reaction mixture was then stirred for 30 minutes at a temperature of -78 °C, followed by the dropwise addition of a solution of cyclopropanecarbaldehyde (35.3 g, 503 mmol, 37.6 mL, 2.20 eq) in abs. tetrahydrofuran (40.0 20 mL), and the reaction mixture was stirred for 60 minutes at a temperature of -78 °C.After complete conversion (thin-layer chromatography and LC-MS control), the reaction mixture was treated with aqueous NH4Cl solution (500 mL) and extracted several times with EtOAc (200 mL x 3). The combined organic phases were washed with saturated NaCl solution (200 mL), dried over Na2SO4, filtered, and concentrated under reduced pressure. The remaining residue was purified by column chromatography (SiO2, petroleum ether / ethyl acetate = 5:1 to 20:1), and (3-bromopyrazin-2-yl)(cyclopropyl)methanol (45.0 g, 78% of theory) was obtained as a yellowish oil. Synthesis step 2: 3-bromopyrazin-2-yl)(cyclopropyl)methanone. (3-Bromopyrazin-2-yl)(cyclopropyl)methanol (45.0 g, 196 mmol, 1.00 eq) was dissolved in absolute dichloromethane (315 mL), mixed with pyridinium chlorochromate (PCC, 84.7 g, 393 mmol, 2.00 eq), and stirred at room temperature for 12 h using BCS241005-Ausland STR 79. After complete conversion (reaction checked by thin-layer chromatography), the reaction mixture was filtered and concentrated under reduced pressure. Column chromatographic purification of the remaining residue (SiO₂, petroleum ether / ethyl acetate = 5:1 to 20:1) yielded 3-bromopyrazin-2-yl)(cyclopropyl)methanone (24.0 g, 54% of theory) as a yellow solid. 1 H-NMR (400 MHz, CDCl3): δ (ppm) = 8.51-8.55 (m, 1H) 8.38-8.42 (m, 1H) 2.76-2.85 (m, 1H), 1.29 (m, 2H), 1.06-1.14 (m, 2H). Synthesis step 3: tert-Butyl-[(3-bromopyrazin-2-yl)(cyclopropyl)methyl]carbamate 10. In the next step, ammonium acetate (91.7 g, 1.19 mol, 15.0 eq) was added to a solution of 3-bromopyrazin-2-yl)(cyclopropyl)methanone (18.0 g, 79.3 mmol, 1.00 eq) in abs. MeOH (126 mL) at room temperature. The resulting reaction mixture was stirred for 2 h at a temperature of 60 °C, then NaBH3CN (49.8 g, 793 mmol, 10.0 eq) was added and stirred for another 10 h at a temperature of 60 °C. After complete conversion (reaction control via LC-MS), the reaction mixture was concentrated under reduced pressure, and the resulting yellow solid, 1-(3-bromopyrazin-2-yl)-1-cyclopropylmethanamine (18.0 g, 78.9 mmol, 1.00 eq), was used in the next reaction step without further purification and dissolved in a mixture of tetrahydrofuran (36.0 mL) and H₂O (54.0 mL). Then, Na₂CO₃ (25.1 g, 237 mmol, 3.00 eq) and Boc₂O (25.8 g, 118 mmol, 1.50 eq) were added, and the resulting reaction mixture was stirred at room temperature for 12 h.20. After complete conversion (reaction control by LC-MS), the reaction mixture was thoroughly extracted with EtOAc (100 mL x 3), washed with aqueous NaCl solution (100 mL), dried over Na₂SO₄, filtered, and concentrated under reduced pressure. Column chromatographic purification of the remaining residue (SiO₂, petroleum ether / ethyl acetate = 5:1 to 20:1) yielded tert-butyl-[(3-bromopyrazin-2-yl)(cyclopropyl)methyl]carbamate (11.0 g, 43% of theory) as a colorless solid. Synthesis step 4: Methyl-4-(3-{[(tert-butoxycarbonyl)amino](cyclopropyl)methyl}pyrazin-2-yl)benzoate. BCS241005-Abroad STR 80 tert-Butyl-[(3-brompyrazin-2-yl)(cyclopropyl)methyl]carbamate (10.0 g, 30.5 mmol, 1.00 eq), Methyl-4- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (11.9 g, 45.7 mmol, 1.50 eq), K2CO3(8.42 g, 60.9 mmol, 2.00 eq) and Pd(dppf)Cl2(2.23 g, 3.05 mmol, 0.100 eq) were dissolved under argon in abs. Dioxane (50.0 mL) and H₂O (10.0 mL) were dissolved, and the resulting reaction mixture was stirred under argon at a temperature of 5–100 °C for 12 h. The reaction progress was monitored by LC-MS, and after complete conversion of the starting materials, the reaction mixture was cooled to room temperature, extracted with EtOAc (100 mL x 3), washed with aqueous NaCl solution (100 mL), dried over Na₂SO₄, filtered, and concentrated under reduced pressure. By column chromatographic purification of the remaining residue (SiO₂, petroleum ether / ethyl acetate = 5:1 to 20:1), methyl 4-10(3-{[(tert-butoxycarbonyl)amino](cyclopropyl)methyl}pyrazin-2-yl)benzoate (11.0 g, 94% of theory) in the form of a yellowish solid. Synthesis step 5: Methyl-4-(3-[amino(cyclopropyl)methyl]pyrazin-2-yl)benzoate. Methyl 4-(3-{[(tert-butoxycarbonyl)amino](cyclopropyl)-methyl}pyrazin-2-yl)benzoate (4.00 g, 10.4 mmol, 1.00 eq) was then dissolved in HCl / dioxane (4.00 mL) and dichloromethane (20.0 mL) and stirred for 12 h at room temperature. The reaction mixture was then concentrated under reduced pressure and the remaining residue was recrystallized from ethyl acetate (50.0 mL). In this way, methyl 4-(3-[amino(cyclopropyl)methyl]pyrazin-2-yl)benzoate (3.06 g, 91% of theory) was obtained as a yellowish solid. Synthesis step 6: (rac)-methyl-4-(3-{[3,5-bis(trifluoromethyl)benzamido](cyclopropyl)methyl}pyrazin-2-yl)benzoate (I.1-284) 25 Methyl-4-(3-[amino(cyclopropyl)methyl]pyrazin-2-yl)benzoate (250 mg, 0.78 mmol, 1.0 eq) was dissolved in absolute dichloromethane under argon in a heated round-bottom flask and, after stirring for 5 minutes at room temperature, treated with triethylamine (0.33 mL, 2.34 mmol, 3.0 eq), 3,5-bis(trifluoromethyl)benzoic acid BCS241005-Ausland STR 81 (202 mg, 0.78 mmol, 1.0 eq), and 50% propanephosphonic anhydride in THF (0.84 mL, 1.40 mmol, 1.8 eq). The resulting reaction mixture was stirred for 14 h at room temperature, then treated with dichloromethane and washed with dilute HCl (1 M). The organic phase was dried over sodium sulfate, filtered, and concentrated under reduced pressure. Methyl-4-(3-{[3,5-bis(trifluoromethyl)benzamido](cyclopropyl)-methyl}pyrazin-2-yl)benzoate (I.1-284) was obtained as a colorless solid (350 mg, 83% of theory) by five column chromatographic purifications of the crude product (gradient heptane / ethyl acetate). 1H NMR (400 MHz, CDCl3): δ (ppm) = 8.65 (d, J = 2.2 Hz, 1H), 8.60 (d, J = 2.2 Hz, 1H), 8.29 (s, 2H), 8.23 (d, J = 8.3 Hz, 2H), 8.03 (s, 1H), 7.84-7.81 (m, 2H), 7.43 (br d, J = 7.9 Hz, 1H), 5.13 (t, J = 8.4 Hz, 1H), 3.98 (s, 3H), 1.22 - 1.13 (m, 1H), 10 0.56-0.49 (m, 1H), 0.40-0.31 (m, 2H), -0.03 - -0.11 (m, 1H). Nr. I.2-48: (rac)-Methyl-3-{3-[1-(3-chlor-5-iodbenzamido)propyl]pyrazin-2-yl}benzoat Synthesestufe 1: 1-(2-Brompyrazin-3-yl)propan-1-ol 15 A solution of N-isopropylpropan-2-amine (87.8 g, 868 mmol, 123 mL, 2.30 eq) in absolute tetrahydrofuran (420 mL) was cooled to -78 °C under a nitrogen atmosphere and treated dropwise with a solution of n-butyllithium in absolute tetrahydrofuran (2.5 M, 332 mL, 2.20 eq). The resulting reaction mixture was stirred for 30 minutes at -30 °C, cooled again to -78 °C, and treated dropwise with a solution of 2-bromopyrazine (60.0 g, 377 mmol, 1.00 eq) in absolute tetrahydrofuran (180 mL). The resulting reaction mixture was then stirred for 30 minutes at a temperature of -78 °C, followed by the dropwise addition of a solution of propanal (48.2 g, 830 mmol, 60.4 mL, 2.20 eq) in abs. tetrahydrofuran (60.0 mL) and the reaction mixture was stirred for 60 minutes.After complete conversion (thin-layer chromatography and LC-MS control), the reaction mixture was treated with aqueous NH4Cl solution (500 mL) and extracted several times with EtOAc (200 mL x 3). The combined organic phases were washed with saturated NaCl solution (200 mL), dried over Na2SO4, filtered, and concentrated under reduced pressure. The remaining residue was purified by column chromatography (SiO2, petroleum ether / ethyl acetate = 5:1 to 20:1), and 1-(2-30-bromopyrazin-3-yl)propan-1-ol (30.0 g, 32.9% of theory) was obtained as a yellowish oil. BCS241005-Abroad STR 82 Synthesis Step 2: 1-(2-bromopyrazin-3-yl)propan-1-one. 1-(2-Bromopyrazin-3-yl)propan-1-ol (26.0 g, 120 mmol, 1.00 eq) was dissolved in absolute dichloromethane (182 mL), mixed with pyridinium chlorochromate (PCC, 52.0 g, 240 mmol, 2.00 eq), and stirred for 12 h at room temperature. After complete conversion (reaction checked by thin-layer chromatography), the reaction mixture was filtered and concentrated under reduced pressure. Column chromatographic purification of the remaining residue (SiO₂, petroleum ether / ethyl acetate = 5:1 to 20:1) yielded 1-(2-bromopyrazin-3-yl)propan-1-one (21.0 g, 81.5% of theory) as a yellow solid. 1 H-NMR (400 MHz, CDCl3): δ (ppm) = 8.56 - 8.60 (m, 1 H) 8.49 (d, J=2.38 Hz, 1 H) 3.13 (q, J=7.17 Hz, 2 H) 1.25 (t, J=7.25 Hz, 3 H). Synthesis step 3: tert-Butyl-[1-(3-bromopyrazin-2-yl)propyl]carbamate 15 In the next step, ammonium acetate (96.8 g, 1.26 mol, 15.0 eq) was added to a solution of 1-(2-bromopyrazin-3-yl)propan-1-one (18.0 g, 83.7 mmol, 1.00 eq) in abs. MeOH (126 mL) at room temperature. The resulting reaction mixture was stirred for 2 h at a temperature of 60 °C, then NaBH3CN (52.6 g, 837 mmol, 10.0 eq) was added and stirred for 10 h at a temperature of 60 °C. After complete conversion (reaction control via LCMS), the reaction mixture was concentrated under reduced pressure, and the 1-(3-bromopyrazin-2-yl)propan-1-amine (18.0 g, 83.3 mmol, 1.00 eq), obtained as a yellow solid, was used in the next reaction step without further purification and dissolved in a mixture of tetrahydrofuran (36.0 mL) and H₂O (54.0 mL). Then, Na₂CO₃ (26.5 g, 250 mmol, 3.00 eq) and Boc₂O (27.3 g, 125 mmol, 28.7 mL, 1.50 eq) were added, and the resulting reaction mixture was stirred for 12 h at room temperature.After complete conversion (reaction control by LC-MS), the reaction mixture was thoroughly extracted with EtOAc (100 mL x 3), washed with aqueous NaCl solution (100 mL), dried over Na₂SO₄, filtered, and concentrated under reduced pressure. Column chromatographic purification of the remaining residue (SiO₂, petroleum ether / ethyl acetate = 5:1 to 20:1) yielded tert-butyl-[1-(3-bromopyrazin-2-yl)propyl]carbamate (13.0 g, 49.3% of theory) as a colorless solid. BCS241005-Ausland STR 83 Synthesis Step 4: Methyl-3-(3-{1-[(tert-butoxycarbonyl)amino]propyl}pyrazin-2-yl)benzoate. tert-Butyl-[1-(3-bromopyrazin-2-yl)propyl]carbamate (11.5 g, 36.4 mmol, 1.00 eq), Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (14.3 g, 54.6 mmol, 1.50 eq), K2CO3 (10.0 g, 72.7 mmol, 2.00 eq) and Pd(dppf)Cl2 (2.66 g, 3.64 mmol, 0.100 eq) were dissolved under argon in abs. dioxane (57.5 mL) and H2O (11.5 mL), and the resulting reaction mixture was stirred under argon at a temperature of 100 °C for 12 h. The reaction progress was monitored by LC-MS, and after complete conversion of the starting materials, the reaction mixture was cooled to room temperature, extracted with EtOAc (100 mL x 3), washed with aqueous NaCl solution (100 mL), dried over Na₂SO₄¹⁰, filtered, and concentrated under reduced pressure. By column chromatographic purification of the remaining residue (SiO₂, petroleum ether / ethyl acetate = 5:1 to 20:1), methyl 3-(3-{1-[(tert-butoxycarbonyl)amino]propyl}pyrazin-2-yl)benzoate (12.0 g, 89% of theory) in the form of a yellowish solid. 15 Synthesis step 5: Methyl-3-[3-(1-aminopropyl)pyrazin-2-yl]benzoate. Methyl 3-(3-{1-[(tert-butoxycarbonyl)amino]propyl}pyrazin-2-yl)benzoate (4.00 g, 10.7 mmol, 1.00 eq) was then dissolved in HCl / dioxane (4.00 mL) and dichloromethane (20.0 mL) and stirred for 12 h at room temperature. The reaction mixture was then concentrated under reduced pressure, and the remaining residue was recrystallized from ethyl acetate (50.0 mL). In this way, methyl 3-[3-(1-aminopropyl)pyrazin-2-yl]benzoate (3.04 g, 92% of theory) was obtained as a yellowish solid. 1H-NMR (400 MHz, CDCl3): δ (ppm) = 8.83 (q, J=2.36 Hz, 2 H) 8.74 (br s, 2 H) 8.17 - 8.21 (m, 1 H) 8.13 (dt, J=7.89, 1.25 Hz, 1 H) 7.98 - 8.03 (m, 1 H) 7.71 - 7.78 (m, 1 H) 4.36 (t, J=6.85 Hz, 1 H) 3.87 - 3.93 (m, 3 H) 1.75 - 1.91 (m, 2 H) 0.63 (t, J=7.46 Hz, 3 H). 25 BCS241005-Ausland STR 84 Synthesestufe 6: Nr. I.2-48: (rac)-Methyl-3-{3-[1-(3-chlor-5-iodbenzamido)propyl]pyrazin-2- yl}benzoat Methyl 3-[3-(1-aminopropyl)pyrazin-2-yl]benzoate (300 mg, 0.97 mmol, 1.0 eq) was dissolved under argon in a heated round-bottom flask in absolute acetonitrile (10 mL) and, after stirring for 5 minutes at room temperature, was treated with triethylamine (0.41 mL, 2.92 mmol, 3.0 eq), 3-chloro-5-iodobenzoic acid (275 mg, 0.97 mmol, 1.0 eq), and 50% propanephosphonic anhydride in THF (1.04 mL, 1.75 mmol, 1.8 eq). The resulting reaction mixture was stirred for 6 h at room temperature, then treated with dichloromethane and washed with dilute HCl (1 M). The organic phase was dried over sodium sulfate, filtered, and concentrated under reduced pressure. Methyl-3-{3-[1-(3-chloro-5-iodobenzamido)propyl]pyrazin-2-yl}benzoate (I.2-48) was obtained as a colorless solid (304 mg, 57% of theory) by column chromatographic purification of the crude product (gradient heptane / ethyl acetate). 1H-NMR (Peakpicking: 400 MHz, CDCl3): δ= 8.6366 (2.6); 8.6306 (3.3); 8.5933 (3.1); 8.5874 (2.4); 8.3196 (1.6); 8.3157 (2.6); 8.3117 (1.5); 8.1982 (1.4); 8.1787 15 (1.5); 8.0119 (1.9); 8.0084 (3.1); 8.0049 (1.8); 7.9370 (1.2); 7.9177 (1.4); 7.8423 (1.8); 7.8382 (2.8); 7.8341 (1.7); 7.7511 (2.0); 7.7470 (2.8); 7.7429 (1.6); 7.6635 (1.3); 7.6441 (2.4); 7.6249 (1.2); 7.2630 (9.0); 7.1555 (0.9); 7.1341 (0.9); 5.5674 (0.9); 5.5506 (0.9); 5.5315 (0.5); 5.3018 (7.6); 3.9517 (16.0); 2.0476 (0.8); 1.8385 (0.8); 1.8225 (0.8); 1.8045 (0.7); 1.7874 (0.8); 1.7691 (1.1); 1.7510 (0.9); 1.7344 (0.6); 1.5958 (2.0); 1.2607 (1.1); 0.8817 (0.8); 0.7828 (3.0); 0.7643 (6.4); 0.7458 (2.9); -0.0002 (11.2); - 20 0.0083 (0.7) Nr. I.2-98: Methyl-3-(3-{[3-Brom-5-(trifluormethoxy)benzamido](cyclopropyl)methyl}pyrazin-2- yl)benzoat 25 Synthesestufe 1: (3-Brompyrazin-2-yl)(cyclopropyl)methanol A solution of N-isopropylpropan-2-amine (58.6 g, 579 mmol, 82 mL, 2.30 eq) in absolute tetrahydrofuran (280 mL) was cooled to -78 °C under an argon atmosphere and treated dropwise with 30 ml of a solution of n-butyllithium in absolute tetrahydrofuran (2.5 M, 221 mL, 2.20 eq). The resulting reaction mixture was stirred for 30 minutes at -30 °C, cooled again to -78 °C, and treated dropwise with a solution of 2-bromopyrazine (40.0 g, 252 mmol, 1.00 eq) in absolute tetrahydrofuran (120 mL). The resulting reaction mixture was then stirred for 30 minutes at a temperature of -78 °C, followed by the dropwise addition of a solution of cyclopropanecarbaldehyde (35.3 g, 503 mmol, 37.6 mL, 2.20 eq) in abs. tetrahydrofuran (40.0 mL), and the reaction mixture was stirred for 60 minutes at a temperature of -78 °C.After complete conversion (thin-layer chromatography and LC-MS control), the reaction mixture was treated with aqueous NH4Cl solution (500 mL) and extracted several times with EtOAc (200 mL x 3). The combined organic phases were washed with saturated NaCl solution (200 mL x 10 mL), dried over Na2SO4, filtered, and concentrated under reduced pressure. The remaining residue was purified by column chromatography (SiO2, petroleum ether / ethyl acetate = 5:1 to 20:1), and (3-bromopyrazin-2-yl)(cyclopropyl)methanol (45.0 g, 78% of theory) was obtained as a yellowish oil. 15 Synthesis step 2: 3-bromopyrazin-2-yl)(cyclopropyl)methanone. (3-Bromopyrazin-2-yl)(cyclopropyl)methanol (45.0 g, 196 mmol, 1.00 eq) was dissolved in absolute dichloromethane (315 mL), mixed with pyridinium chlorochromate (PCC, 84.7 g, 393 mmol, 2.00 eq), and stirred for 12 h at room temperature. After complete conversion (reaction checked by 20 thin-layer chromatography), the reaction mixture was filtered and concentrated under reduced pressure. Column chromatographic purification of the remaining residue (SiO₂, petroleum ether / ethyl acetate = 5:1 to 20:1) yielded 3-bromopyrazin-2-yl)(cyclopropyl)methanone (24.0 g, 54% of theory) as a yellow solid. 1 H-NMR (400 MHz, CDCl3): δ (ppm) = 8.51-8.55 (m, 1H) 8.38-8.42 (m, 1H) 2.76-2.85 (m, 1H), 1.29 (m, 2H), 1.06-1.14 (m, 2H). 25 Synthesis step 3: tert-Butyl-[(3-bromopyrazin-2-yl)(cyclopropyl)methyl]carbamate In the next step, ammonium acetate (91.7 g, 1.19 mol, 15.0 eq) was added to a solution of 3-bromopyrazin-2-yl)(cyclopropyl)methanone (18.0 g, 79.3 mmol, 1.00 eq) in abs. MeOH (126 mL) at room temperature. The resulting reaction mixture was stirred for 2 h at a temperature of 60 °C, then NaBH3CN (49.8 g, 793 mmol, 10.0 eq) was added and stirred for 10 h at a temperature of 60 °C. After complete conversion (reaction control via LC-MS), the reaction mixture was concentrated under reduced pressure, and the 1-(3-bromopyrazin-2-yl)-1-cyclopropylmethanamine (18.0 g, 78.9 mmol, 1.00 eq), obtained as a yellow solid, was used in the next reaction step without further purification and dissolved in a mixture of tetrahydrofuran (36.0 mL) and H₂O (54.0 mL). Then, Na₂CO₃ (25.1 g, 237 mmol, 3.00 eq) and Boc₂O (25.8 g, 118 mmol, 1.00 eq) were dissolved.50 eq) was added and the resulting reaction mixture was stirred for 12 h at room temperature. After complete conversion (reaction control by LC-MS), the reaction mixture was thoroughly extracted with EtOAc (100 mL x 3), washed with aqueous NaCl solution (100 mL), dried over Na₂SO₄, filtered, and concentrated under reduced pressure. Column chromatographic purification of the remaining residue (SiO₂, petroleum ether / ethyl acetate = 5:1 to 20:1) yielded tert-butyl-[(3-bromopyrazin-2-yl)(cyclopropyl)methyl]carbamate (11.0 g, 43% of theory) as a colorless solid. Synthesis step 4: Methyl-3-(3-{[(tert-butoxycarbonyl)amino](cyclopropyl)methyl}pyrazin-2-yl)benzoate 15. tert-Butyl-[(3-brompyrazin-2-yl)(cyclopropyl)methyl]carbamate (10.0 g, 30.5 mmol, 1.00 eq), Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (11.9 g, 45.7 mmol, 1.50 eq), K2CO3(8.42 g, 60.9 mmol, 2.00 eq) and Pd(dppf)Cl2(2.23 g, 3.05 mmol, 0.100 eq) were dissolved under argon in abs. dioxane (50.0 mL) and H2O (10.0 mL), and the resulting reaction mixture was stirred under argon at a temperature of 20–100 °C for 12 h. The reaction progress was monitored by LC-MS, and after complete conversion of the starting materials, the reaction mixture was cooled to room temperature, extracted with EtOAc (100 mL x 3), washed with aqueous NaCl solution (100 mL), dried over Na₂SO₄, filtered, and concentrated under reduced pressure. By column chromatographic purification of the remaining residue (SiO₂, petroleum ether / ethyl acetate = 5:1 to 20:1), methyl 3-25(3-{[(tert-butoxycarbonyl)amino](cyclopropyl)methyl}pyrazin-2-yl)benzoate (10.6 g, 90% of theory) in the form of a yellowish solid. Synthesis step 5: Methyl-3-(3-[amino(cyclopropyl)methyl]pyrazin-2-yl)benzoate BCS241005-Ausland STR 87. Methyl 3-(3-{[(tert-butoxycarbonyl)amino](cyclopropyl)-methyl}pyrazin-2-yl)benzoate (4.00 g, 10.4 mmol, 1.00 eq) was then dissolved in HCl / dioxane (4.00 mL) and dichloromethane (20.0 mL) and stirred for 12 h at room temperature. The reaction mixture was then concentrated under reduced pressure, and the remaining residue was recrystallized from ethyl acetate (50.0 mL). In this way, methyl 4-(3-[amino(cyclopropyl)methyl]pyrazin-2-yl)benzoate (2.91 g, 87% of theory) was obtained as a colorless solid. Synthesis step 6: (rac)-methyl-3-(3-{[3-bromo-5-10(trifluoromethoxy)benzamido](cyclopropyl)methyl}pyrazin-2-yl)benzoate (I.2-98) Methyl 3-(3-[amino(cyclopropyl)methyl]pyrazin-2-yl)benzoate (300 mg, 0.94 mmol, 1.0 eq) was dissolved in absolute dichloromethane under argon in a heated round-bottom flask and, after stirring for 10 minutes at room temperature, treated with triethylamine (0.39 mL, 2.81 mmol, 3.0 eq), 3-bromo-5-15(trifluoromethoxy)benzoic acid (262 mg, 0.92 mmol, 1.0 eq), and 50% propanephosphonic anhydride in THF (1.01 mL, 1.69 mmol, 1.8 eq). The resulting reaction mixture was stirred for 12 h at room temperature, then treated with dichloromethane and washed with dilute HCl (1 M). The organic phase was subsequently dried over magnesium sulfate, filtered, and concentrated under reduced pressure. Column chromatographic purification of the crude product (gradient 20 heptane / ethyl acetate) yielded methyl 3-(3-{[3-bromo-5-(trifluoromethoxy)benzamido](cyclopropyl)methyl}pyrazin-2-yl)benzoate (I.2-98) as a colorless solid (406 mg, 74% of theory). 1H NMR (400 MHz, CDCl3): δ (ppm) = 8.64-8.63 (d, , 1H), 8.59-6.58 (d, 1H), 8.38 (s, 1H), 8.19-8.17 (d, 1H), 7.98-7.97 (d, 1H), 7.87 (s, 1H), 7.65-7.60 (m, , 2H), 7.53 (s, 1H), 5.13-5.09 (t, 1H), 3.95 (s, 3H), 1.25 - 1.19 (m, 1H), 0.55-0.48 (m, 1H), 0.42-0.30 (m, 25 2H), 0.06 - 0.02 (m, 1H). By analogy to the preparation examples cited above and quoted at the appropriate point BCS241005-Ausland STR 88 and taking into account the general information on the preparation of substituted arylpyrazines, the following compounds are obtained. If, in Tables I.1 to I.3, a structural element is defined by a structural formula containing a dashed line, this dashed line indicates that the group in question is bonded to the rest of the molecule at that position. The corresponding stereochemical configuration at the stereocenter C-1 (see formula I. below)1) is designated by the terms “Rac” for a racemic mixture of both enantiomers, “Ent-1” for the enantiomer with the lower retention time in chiral HPLC analysis or chiral preparative SFC, and “Ent-2” for the enantiomer with the higher retention time in chiral HPLC analysis or chiral preparative SFC. In the following 10 tables, the terms 1-methyleth-1-yl, 1-methylethyl, and propyl-2-yl refer to an isopropyl group, and the different names for the same group are common in the field. Table I.1: Preferred compounds of formula (I.1) are compounds I.1-1 to I.1-559, where Q has the meanings given in the respective row of Table I.1. The compounds I.1-1 to 15 I.1-559 of Table I.1 are thus identified by the meaning of the respective entries for the substituents R. 1 , R 7 , R 17 , R 18 and R 19 defined in Table I.1, where R 2, R 5 and R 6 for hydrogen. Table I.1: 20 BCS241005-Abroad STR 89 BCS241005-Abroad STR 90 BCS241005-Abroad STR 91 BCS241005-Abroad STR 92 BCS241005-Abroad STR 93 BCS241005-Abroad STR 94 BCS241005-Abroad STR 95 BCS241005-Abroad STR 96 BCS241005-Abroad STR 97 BCS241005-Abroad STR 98 BCS241005-Abroad STR 99 BCS241005-Abroad STR 100 BCS241005-Abroad STR 101 BCS241005-Abroad STR 102 BCS241005-Abroad STR 103 Table I.2: Preferred compounds of formula (I.2) are compounds I.2-1 to I.2-225, where Q has the meanings given in the respective row of Table I.2. Compounds I.2-1 to I.2-225 of Table I.2 are thus distinguished by the meaning of the respective entries for the substituents R. 1 , 5 R7 , R 18 , R 19 and R 20 defined in Table I.2, where R 2 , R 5 and R 6 stand for hydrogen. Table I.2: BCS241005-Abroad STR 104 BCS241005-Abroad STR 105 BCS241005-Abroad STR 106 BCS241005-Abroad STR 107 BCS241005-Abroad STR 108 BCS241005-Abroad STR 109 Table I.3: Preferred compounds of formula (I.3) are compounds I.3-1 to I.3-18, where Q has the meanings given in the respective row of Table I.3. Compounds I.3-1 to I.3-18 of Table I.3 are thus distinguished by the meaning of the respective entries for the substituents R. 1 , 5 R 7 , R 17 , R 18 and R 20 defined in Table 3, where R 2 , R 5 and R 6 stand for hydrogen. BCS241005-Abroad STR 110 Table I.3: Spectroscopic data of selected examples from the tables listed above: 5 The spectroscopic data of the table examples listed below were obtained either using classical 1 H-NMR interpretation or evaluated via the NMR peak list method. a) classical NMR interpretation 10 BCS241005-Ausland STR 111 I.1-86: 1 H-NMR (400 MHz, d6-DMSO): δ= 8.73 (d,1H); 8.66 (d,1H); 8.64 (d,1H); 8.06 (d,2H); 7.79 (d,2H); 7.32 (dd,1H); 7.29 (d,1H); 7.12 (d,1H); 5.26 (m,1H); 4.35 (t,2H); 3.21 (t,2H); 1.41 (d,3H) I.1-91: 1 H NMR (400 MHz, CDCl3): δ= 8.62 (d,1H); 8.58 (d,1H); 8.21 (d,2H); 7.75 (d,2H); 7.35 5 (dd,1H); 7.30 (d,1H); 7.18 (d,1H); 6.84 (d,1H); 6.02 (s,2H); 5.63 (m,1H); 3.97 (s,3H); 1.39 (d,3H) I.1-92: 1 H-NMR (400 MHz, d6-DMSO): δ= 8.68 (d,1H); 8.65 (d,1H); 8.63 (d,1H); 8.06 (d,2H); 7.79 (d,2H); 7.74 (d,1H); 7.52 (dd,1H); 6.89 (d,1H); 5.83 (s,2H); 5.26 (m,1H); 1.42 (d,3H) 10 I.1-93: 1H-NMR (400 MHz, d6-DMSO): δ= 8.67 (d,1H); 8.66 (d,1H); 8.63 (d,1H); 8.07 (dd,2H); 7.80 (dd,2H); 7.42 (dd,1H); 7.37 (d,1H); 6.95 (d,1H); 6.07 (s,2H); 5.27 (m,1H); 1.42 (d,3H) I.1-102: 1 H-NMR (600 MHz, d 6 -DMSO, ppm) 9.17 (bd, 1H), 8.98 (s, 2H), 8.70 (d, 1H), 8.67 (d, 1H), 8.07 (d, 2H), 7.80 (d, 2H), 5.32 (m, 1H), 3.90 (s, 3H), 2.65 (s, 3H), 1.47 (d, 3H). 15 I.1-103: 1 H-NMR (600 MHz, d 6 -DMSO, ppm): δ = 8.65 (m, 1H), 8.67 (d, 1H), 8.64 (d, 1H), 8.07 (d, 2H), 7.81 (d, 2H), 7.56 (d, 2H), 7.33 (m, 1H), 5.28 (m, 1H), 3.90 (s, 3H), 2.26 (s, 3H), 1.44 (d, 3H). I.1-104: 1 H-NMR (600 MHz, d 6 -DMSO, ppm): δ = 8.93 (bd, 1H), 8.75 (d, 1H), 8.71 (d, 1H), 8.46 (d, 20 1H), 8,11 (d, 2H), 7.79 (d, 2H), 7.47 (d, 1H), 7.16 (m, 1H), 5.34 (m, 1H), 3.91 (s, 3H), 1.42 (d, 3H). I.1-105: 1 H-NMR (600 MHz, d 6-DMSO, ppm): δ = 8.96 (s, 1H), 8.91 (d, 1H), 8.74 (s, 1H), 8.70 (s, 1H), 8.61 (s, 1H), 8.10 (d, 2H), 7.79 (d, 2H), 5.38 (m, 1H), 3.91 (s, 3H), 2.58 (s, 3H), 1.43 (d, 3H). 25 I.1-106: 1 H-NMR (400 MHz, CDCl3): δ= 8.68 (d,1H); 8.66 (d,1H); 8.59 (d,1H); 8.44 (d,1H); 8.29 (dd,1H); 8.23 (d,2H); 7.73 (d,2H); 7.53 (d,1H); 5.69 (m,1H); 3.98 (s,3H); 3.48 (s,3H); 3.45 (s,3H); 1.44 (d,3H) I.1-107: 1 H-NMR (400 MHz, CDCl3): δ= 8.67 (d,1H); 8.58 (d,1H); 8.24 (d,2H); 7.77 (d,1H); 7.74 30 (d,2H); 7.61 (dd,1H); 7.58 (d,1H); 7.42 (d,1H); 5.67 (m,1H); 5.09 (s,2H); 3.98 (s,3H); 1.41 (d,3H) I.1-108: 1 H-NMR (400 MHz, CDCl3): δ= 8.65 (d,1H); 8.59 (d,1H); 8.23 (d,2H); 7.96 (dd,1H); 7.74 (d,2H); 7.66 (dd,1H); 7.59 (ddd,1H); 7.42 (d,1H); 5.67 (m,1H); 5.55 (d,1H); 5.06 (d,1H); 3.98 (s,3H); 1.41 (d,3H) 35 BCS241005-Ausland STR 112 I.1-109: 1H-NMR (400 MHz, d6-DMSO): δ= 9.06 (d,1H); 8.68 (d,1H); 8.66 (d,1H); 8.08 (d,2H); 7.80 (d,2H); 7.79 (d,1H); 7.53 (dd,1H); 7.43 (d,1H); 5.28 (m,1H); 4.79 (m,2H); 3.90 (s,3H); 3.88 (m,2H); 1.45 (d,3H) 5 I.1-110: 1 H-NMR (400 MHz, CDCl3): δ= 8.65 (d,1H); 8.60 (d,1H); 8.22 (dd,2H); 8.13 (dd,1H); 8.10 (d,1H); 7.73 (d,2H); 7.39 (d,1H); 7.19 (d,1H); 5.66 (m,1H); 5.12 (s,2H); 3.97 (s,3H); 1.40 (d,3H) I.1-111: 1 H-NMR (400 MHz, d6-DMSO): δ= 9.14 (d,1H); 8.67 (d,1H); 8.65 (d,1H); 8.34 (d,1H); 8.08 (d,2H); 7.96 (dd,1H); 7.82 (d,2H); 7.11 (d,1H); 5.29 (m,1H); 4.81 (m,2H); 3.90 (s,3H); 3.89 (m,2H); 10 1.45 (d,3H) I.1-112: 1 H-NMR (400 MHz, d6-DMSO): δ= 9.03 (d,1H); 8.68 (d,1H); 8.66 (d,1H); 8.07 (d,2H); 7.79 (d,2H); 7.69 (d,1H); 7.37 (d,1H); 7.35 (s,1H); 5.28 (m,1H); 3.67 (t,2H); 3.58 (t,2H); 1.44 (d,3H) 15 I.1-113: 1H-NMR (400 MHz, d6-DMSO): δ= 8.97 (d,1H); 8.67 (d,1H); 8.64 (d,1H); 8.17 (d,1H); 8.06 (d,2H); 7.97 (dd,1H); 7.80 (d,2H); 7.01 (d,1H); 5.28 (m,1H); 3.67 (t,2H); 3.59 (t,2H); 1.43 (d,3H) I.1-114: 1 H-NMR (400 MHz, CDCl3): δ= 8.68 (d,1H); 8.61 (d,1H); 8.37 (d,1H); 8.36 (dd,1H); 8.23 (d,2H); 8.08 (d,1H); 7.72 (d,2H); 7.58 (d,1H); 5.68 (m,1H); 4.76 (s,2H); 3.98 (s,3H); 1.43 (d,3H) 20 I.1-130: 1 H-NMR (400 MHz, CDCl3): δ= 8.67 (d,1H); 8.60 (d,1H); 8.36 (d,1H); 8.27 (dd,1H); 8.23 (d,2H); 8.10 (d,1H); 7.72 (d,2H); 7.51 (d,1H); 5.68 (m,1H); 4.11 (s,4H); 3.98 (s,3H); 1.42 (d,3H) I.1-141: 1 H-NMR (400 MHz, CDCl3): δ= 8.71 (d,1H); 8.60 (d,1H); 8.48 (d,1H); 8.32 (dd,1H); 8.25 25 (d,2H); 8.08 (d,1H); 8.06 (d,1H); 7.75 (d,2H); 5.66 (m,1H); 4.12 (s,4H); 1.48 (d,3H) I.1-162: 1 H-NMR (400 MHz, d 6-DMSO ^, ppm) 9.68 (d, 2H), 8.06 (d, 2H), 7.82 (d, 2H), 7.71 (s, 1H), 7.68 (s, 1H), 7.45 (s, 1H), 5.45 (s, 1H), 5.35 (m, 1H), 3.89 (s, 1H), 1.84-1.82 (m, 2H), 1.74-1.71 (m, 2H), 1.43 (d, 3H). 30 I.1-172: 1 H-NMR (400 MHz, CDCl3): δ= 8.73 (s,1H); 8.67 (d,1H); 8.62 (d,1H); 8.48 (s,2H); 8.31 (t,1H); 8.25 (d,2H); 8.19 (d,1H); 7.76 (d,2H); 7.51 (d,1H); 5.70 (m,1H); 3.98 (s,3H); 3.17 (s,3H); 1.46 (d,3H) I.1-173: 1 H-NMR (400 MHz, d6-DMSO): δ= 9.02 (d,1H); 8.68 (d,1H); 8.66 (d,1H); 8.39 (d,1H); 8.08 35 (d,2H); 8.07 (d,1H); 7.82 (d,2H); 7.81 (dd,1H); 5.36 (m,1H); 2.83 (s,3H); 1.47 (d,3H) BCS241005-Ausland STR 113 I.1-184: 1 H-NMR (400 MHz, d6-DMSO): δ= 9.12 (d,1H); 8.68 (d,1H); 8.66 (d,1H); 8.50 (m,1H); 8.18- 7.9 (m,6H); 7.82 (d,2H); 7.51 (m,1H); 5.38 (m,1H); 1.49 (d,3H) I.1-186: 1H-NMR (400 MHz, d6-DMSO): δ= 9.48 (d,1H); 8.72 (d,1H); 8.70 (d,1H); 8.68 (d,1H); 8.54 5 (t,1H); 8.47 (t,1H); 8.26 (t,1H); 8.07 (d,2H); 7.87 (d,1H); 7.82 (d,2H); 6.64 (dd,1H); 5.38 (m,1H); 3.32 (s,3H); 1.51 (d,3H) I.1-229: 1 H-NMR (400 MHz, d 6 -DMSO, ppm): δ = 8.72 (bd, 1H), 8.67 (s, 1H), 8.64 (s, 1H), 8.08 (d, 2H), 8.05 (s, 1H), 7.80 (d, 2H), 7.50 (s, 1H), 5.24 (m, 1H), 3.91 (s, 3H), 1.42 (d, 3H). 10 I.1-230: 1 H-NMR (400 MHz, d 6 -DMSO, ppm): δ = 8.74 (bd, 1H), 8.70 (s, 1H), 8.68 (s, 1H), 8.10 (d, 2H), 7.78 (d, 2H), 7.30 (s, 1H), 5.23 (m, 1H), 3.91 (s, 3H), 1.43 (d, 3H). I.1-232: 1 H-NMR (400 MHz, d 6 -DMSO, ppm): δ = 8.72 (bd, 1H), 8.69 (s, 1H), 8.68 (s, 1H), 8.08 (d, 15 2H), 7.73 (d, 2H), 7.30 (s, 1H), 5.23 (m, 1H), 1.41 (d, 3H), 1.28 (t, 3H). I.1-239: 1 H-NMR (400 MHz, d 6-DMSO, ppm): δ = 8.84 (bd, 1H), 8.72 (d, 1H), 8.70 (d, 1H), 8.11 (d, 2H), 7.79 (d, 2H), 5.30 (m, 1H), 3.91 (s, 3H), 3.74 (s, 3H), 3.31 (s, 3H), 1.42 (d, 3H). 20 I.1-241: 1 H-NMR (400 MHz, d 6 -DMSO, ppm): δ = 8.77-8.69 (m, 3H), 8.10 (d, 1H), 7.78 (d, 2H), 7.59 (s, 1H), 5.29 (m, 1H), 3.90 (s, 3H), 2.43 (s, 3H), 1.43 (d, 3H). I.1-250: 1 H-NMR (400 MHz, d 6 -DMSO, ppm): δ = 8.77 (d, 1H), 8.74 (d, 1H), 8.38 (d, 1H), 8.12 (d, 2H), 7.95 (d, 2H), 5.33 (m, 1H), 3.95 (s, 3H), 3.91 (s, 3H), 1.39 (d, 3H). 25 I.2-2: 1 H-NMR (400 MHz, d 6 -DMSO, ppm): δ = 8.96 (bd, 1H), 8.15-8.13 (m, 2H), 8.11 (m, 1H), 8.03 (m, 1H), 7.98 (m, 1H), 7.73 (m, 1H), 7.67-7.63 (m, 2H), 7.48 (m, 1H), 7.42 (m, 1H), 5.31 (m, 1H), 1.77- 1.74 (m, 2H), 1.56-1.53 (m, 2H), 1.48 (d, 3H). 30 I.2-156: 1H NMR (400 MHz, CDCl3): δ (ppm) = 8.64-8.63 (d, , 1H), 8.59-6.58 (d, 1H), 8.37 (s, 1H), 8.19- 8.17 (d, 1H), 7.99-7.97 (d, 1H), 7.87 (s, 1H), 7.65-7.60 (m, 2H), 7.53 (s, 1H), 5.13-5.09 (t, 1H), 3.95 (s, 3H), 1.25 - 1.19 (m, 1H), 0.55-0.48 (m, 1H), 0.42-0.30 (m, 2H), 0.06 - 0.02 (m, 1H). I.2-157: 1 H NMR (400 MHz, CDCl3): δ (ppm) = 8.64-8.63 (d, , 1H), 8.59-6.58 (d, 1H), 8.38 (s, 1H), 8.20- 35 8.18 (d, 1H), 7.98-7.96 (d, 1H), 7.88 (s, 1H), 7.65-7.60 (m, , 2H), 7.52 (s, 1H), 5.13-5.09 (t, 1H), 3.95 (s, 3H), 1.25 - 1.19 (m, 1H), 0.55-0.48 (m, 1H), 0.42-0.30 (m, 2H), 0.06 - 0.02 (m, 1H). BCS241005-Ausland STR 114 b) NMR-Peak-Listenverfahren Die 1 H-NMR-Daten ausgewählter Beispiele können auch in Form von 1H-NMR peak lists are recorded. For each signal peak, the ^-value in ppm is listed first, followed by the signal intensity in parentheses. The ^^-value-signal intensity pairs of different signal peaks are listed separated by semicolons. The peak list of an example therefore has the form: ^1(Intensity1) ) ; ^2(Intensity2);……..; ^ i (Intensity i ) ;……; ^ n (Intensity n) 10 The intensity of sharp signals correlates with the height of the signals in a printed example of an NMR spectrum in cm and shows the true ratios of the signal intensities. For broad signals, multiple peaks or the center of the signal and its relative intensity compared to the most intense signal in the spectrum can be shown. To calibrate the chemical shift of 1H-NMR spectra, we use tetramethylsilane and / or the chemical shift of the solvent, especially in the case of spectra measured in DMSO. Therefore, the tetramethylsilane peak may appear in NMR peak lists, but it does not have to. The lists of 1 H-NMR peaks are similar to the classical ones. 1 H-NMR printouts and thus usually contain all the peaks listed in a classical NMR interpretation. Furthermore, they can be interpreted like classical NMR. 1H-20 NMR printouts show solvent signals, signals of stereoisomers of the target compounds, which are also part of the invention, and / or peaks of impurities. When indicating compound signals in the delta region of solvents and / or water, our lists of 1¹H NMR peaks show the usual solvent peaks, for example, peaks of DMSO in DMSO-D6 and the peak of water, which usually exhibit high intensity on average. The peaks of stereoisomers of the target compounds and / or peaks of impurities usually have a lower average intensity than the peaks of the target compounds (for example, with a purity of >90%). Such stereoisomers and / or impurities may be typical for the respective manufacturing process. Their peaks can thus help to recognize the reproducibility of our manufacturing process based on “byproduct fingerprints.” An expert who calculates the peaks of the target compounds using known methods (MestreC, ACD simulation, but also with empirically evaluated expected values) can isolate the peaks of the target compounds as needed, possibly employing additional intensity filters.This isolation would be similar to the peak picking used in classical 1H-NMR interpretation. Further details are available. 1 H-NMR peak lists can be found in the 35 Research Disclosure Database, number 564025. Example No.: BCS241005-Abroad STR 115 I.1-1: 1 H-NMR (400.6 MHz, CDCl3): δ= 8.6688 (2.5); 8.6627 (3.1); 8.6111 (2.3); 8.6049 (2.0); 8.2496 (2.9); 8.2455 (4.8); 8.2406 (1.1); 8.2289 (1.0); 8.2240 (3.4); 8.0194 (1.1); 7.7490 (3.2); 7.7441 (1.0); 7.7324 (0.9); 7.7276 (3.0); 7.2609 (26.9); 5.7125 (0.5); 5.6956 (0.6); 5.6764 (0.6); 3.9778 (16.0); 1.5657 (0.7); 1.4524 (4.6); 1.4356 (4.7); 1.2553 (1.8); 0.0080 (1.1); 0.0022 (1.5); -0.0002 (37.4); -0.0026 (1.7); - 0.0042 (0.7); -0.0084 (1.1) I.1-2: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.4468 (2.8); 9.4303 (3.0); 8.6580 (3.9); 8.6519(14.0); 8.6480(16.0); 8.6419 (4.8); 8.4821 (9.8); 8.2856 (4.5); 8.0102 (7.5); 7.9897 (8.8); 7.6739 (7.2); 7.6534(6.6); 5.4230 (1.9); 5.4061 (3.0); 5.3891 (1.9); 3.3313 (5.2); 2.6805 (0.5); 2.6759 (1.2); 2.6712 (1.7); 2.6667 (1.2); 2.5418 (4.9); 2.5369 (0.9); 2.5323 (1.1); 2.5250 (4.9); 2.5203 ​​(6.4); 2.5116 (95.7); 2.5071 (209.6); 2.5024 (292.9); 2.4979 (200.8); 2.4933 (88.0); 2.3341 (1.3); 2.3295 (1.7); 2.3248 (1.2); 2.3203 (0.5); 1.4922 (11.3); 1.4750 (11.3); 0.1458 (0.7); 0.0295 (0.6); 0.0080 (6.5); -0.0002(230.9); -0.0085 (6.2); -0.1494 (0.7) I.1-3: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6681 (2.4); 8.6621 (2.9); 8.6115 (2.2); 8.6054 (1.8); 8.2494 (2.9); 8.2480 (2.8); 8.2453 (4.8); 8.2404 (1.2); 8.2287 (1.0); 8.2238 (3.3); 8.2197 (0.5); 8.1223 (0.5); 8.0192 (1.1); 7.7488 (3.1); 7.7439 (1.0); 7.7322 (0.9); 7.7273 (2.9); 7.7060 (0.5); 7.2611 (22.8); 5.7126 (0.5); 5.6956 (0.6); 5.6935 (0.6); 5.6765 (0.6); 3.9778 (16.0); 3.9533 (2.6); 1.5782 (1.7); 1.4520 (4.5); 1.4353 (4.5); 0.0079 (0.8); -0.0002 (30.1); -0.0085 (0.9) I.1-4: 1 H-NMR(400.6 MHz, CDCl3): δ= 8.6680 (1.8); 8.6619 (2.2); 8.6116 (1.9); 8.6055 (1.6); 8.2492 (2.9); 8.2449 (3.8); 8.2400 (1.1); 8.2282 (1.0); 8.2234 (3.3); 8.2192 (0.6); 8.0181 (1.2); 7.7498 (3.0); 7.7449 (1.0); 7.7332 (0.9); 7.7283 (2.9); 7.2624 (10.8); 5.7123 (0.5); 5.6953 (0.6); 5.6932 (0.6); 5.6761 (0.5); 3.9776 (16.0); 2.9581 (1.2); 2.9574 (1.2); 2.8851 (1.1); 2.8837 (1.1); 2.8043 (5.2); 1.4526 (4.5); 1.4358 (4.5); 1.4327 (1.2); 1.2915 (0.6); 1.2743 (0.6); -0.0002 (13.1) I.1-5: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6583 (2.5); 8.6523 (3.2); 8.6071 (2.6); 8.6011 (2.2); 8.2421 (0.5); 8.2380 (3.2); 8.2332 (1.2); 8.2214 (1.2); 8.2166 (3.5); 8.2125 (0.8); 7.9645 (1.8); 7.9606 (1.3); 7.9375 (1.8); 7.9359 (1.7); 7.7463 (2.0); 7.7419 (4.3); 7.7371 (1.4); 7.7252 (1.1); 7.7205 (3.2); 7.7164 (0.7); 7.3751 (0.6); 7.3559 (0.6); 7.2613 (14.2); 5.6860 (0.7); 5.6689 (0.8); 5.6498 (0.7); 3.9756 (16.0); 1.5699 (6.2); 1.4295 (5.3); 1.4128 (5.3); -0.0002 (15.4); -0.0084 (0.7) I.1-6: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.2710 (3.2); 9.2545 (3.3); 8.6929 (7.7); 8.6868 (12.1); 8.6681 (13.8); 8.6620 (9.4); 8.1429 (5.8); 8.1391 (3.9); 8.0867 (5.5); 8.0851 (5.6); 8.0670 (1.7); 8.0627 (10.9); 8.0580 (3.6); 8.0463 (3.9); 8.0414 (16.0); 8.0369 (6.8); 7.7909 (1.9); 7.7868 (12.0); 7.7820 (3.8); 7.7703 (3.4); 7.7655 (10.5); 7.7613 (1.6); 5.3529 (2.1); 5.3359 (3.3); 5.3190 (2.2); 4.0570 (0.6); 4.0392 BCS241005-Ausland STR 116 (1.9); 4.0214 (1.9); 4.0036 (0.6); 3.8920 (1.0); 3.3837 (1.9); 2.6771 (0.5); 2.6726 (0.7); 2.6680 (0.5); 2.5431 (0.6); 2.5264 (2.0); 2.5217 (2.7); 2.5130 (39.7); 2.5084 (88.9); 2.5038 (125.6); 2.4992 (87.6); 2.4946 (39.3); 2.3355 (0.5); 2.3308 (0.7); 2.3262 (0.5); 1.9901 (8.9); 1.9108 (6.8); 1.4941 (12.6); 1.4769 (12.6); 1.3565 (1.7); 1.1934 (2.6); 1.1756 (5.3); 1.1578 (2.6); 0.0080 (2.6); 0.0064 (0.7); 0.0056 (0.7); 0.0047 (0.9); -0.0002 (86.2); -0.0050 (1.0); -0.0058 (0.8); -0.0067 (0.7); -0.0085 (2.4) I.1-7: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6670 (2.6); 8.6610 (3.2); 8.6114 (2.6); 8.6053 (2.1); 8.2449 (5.7); 8.2402 (1.4); 8.2284 (1.0); 8.2235 (3.5); 8.2193 (0.6); 8.0190 (1.4); 7.7482 (3.2); 7.7433 (1.2); 7.7317 (1.0); 7.7269 (3.1); 7.7226 (0.6); 7.4505 (0.5); 7.4311 (0.5); 7.2612 (14.8); 5.7124 (0.6); 5.6954 (0.7); 5.6933 (0.7); 5.6762 (0.6); 3.9777 (16.0); 2.8034 (1.8); 1.5696 (5.5); 1.4510 (5.0); 1.4343 (5.0); 0.0080 (0.5); -0.0002 (20.6); -0.0085 (0.6) I.1-8: 1H-NMR(400.6 MHz, CDCl3): δ= 8.7156 (7.9); 8.7095 (9.5); 8.6357 (7.3); 8.6295 (6.4); 8.3037 (16.0); 8.2872 (2.8); 8.2823 (9.3); 8.2782 (1.6); 8.0231 (3.6); 7.8194 (1.8); 7.8079 (1.9); 7.8038 (9.8); 7.7990 (4.4); 7.7873 (2.8); 7.7825 (8.4); 7.7783 (1.3); 7.2643 (0.8); 7.2610 (47.9); 7.2570 (0.6); 5.7676 (1.5); 5.7488 (1.9); 5.7314 (1.6); 3.7575 (1.1); 1.8594 (1.3); 1.5268 (11.4); 1.5100 (11.5); 1.4324 (1.9); 1.2547 (0.8); 1.2424 (1.8); 1.2228 (0.9); 0.0080 (1.9); 0.0039 (0.6); 0.0030 (1.3); 0.0023 (2.2); -0.0002 (68.7); -0.0027 (3.1); -0.0034 (2.1); -0.0043 (1.2); -0.0051 (0.9); -0.0059 (0.8); -0.0067 (0.7); -0.0084 (2.0) I.1-9: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6914 (0.6); 8.6854 (0.7); 8.6707 (0.5); 8.6300 (0.7); 8.6238 (0.6); 8.2954 (0.7); 8.2744 (0.8); 7.7962 (0.8); 7.7752 (0.8); 7.6670 (0.6); 7.2606 (14.8); 5.3000 (16.0); 4.1322 (0.7); 4.1143 (0.8); 2.0469 (3.3); 1.4960 (1.2); 1.4792 (1.2); 1.3332 (0.8); 1.2841 (1.2); 1.2779 (1.5); 1.2599 (4.4); 1.2550 (4.8); 1.2423 (1.8); 0.8802 (0.7); -0.0002 (17.5); -0.0084 (0.9) I.1-10: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.4284 (4.2); 9.4118 (4.4); 8.7014(8.9); 8.6953 (14.2); 8.6771(15.1); 8.6710(10.1); 8.4528(0.5); 8.4354 (14.8); 8.2820 (6.6); 8.0560 (12.5); 8.0516 (4.2); 8.0395 (4.6); 8.0349 (15.3); 7.7911 (14.4); 7.7866(4.6); 7.7745 (4.3); 7.7700(12.5); 5.4131 (0.5); 5.3963 (2.7); 5.3794 (4.2); 5.3624 (2.7); 5.3453 (0.6); 3.5955 (0.9); 2.6747 (0.7); 2.5452 (1.0); 2.5284 (2.1); 2.5237 (3.0); 2.5150 (43.9); 2.5104 (93.8); 2.5059 (129.5); 2.5013 (90.2); 2.4968 (40.5); 2.3376 (0.6); 2.3330 (0.7); 2.3282 (0.5); 1.5215 (16.0); 1.5043 (15.9); 0.0079 (1.9); -0.0002(62.4); -0.0085 (1.8) I.1-11: 1H-NMR (400.6 MHz, CDCl3): δ= 8.8751 (5.7); 8.7310 (5.5); 8.7250 (6.6); 8.6359 (6.5); 8.6298 (9.4); 8.4925 (5.8); 8.3132 (6.0); 8.2928 (7.0); 8.0085 (2.5); 7.9891 (2.7); 7.8053 (6.2); 7.7850 (6.1); 7.2615 (42.5); 5.7614 (1.6); 5.7438 (2.4); 5.7259 (1.8); 5.7082 (0.6); 5.2999 (16.0); 2.3926 (0.8); 2.3737 (0.5); 2.1429 (0.8); 2.0618 (0.7); 2.0480 (1.6); 1.6158 (0.6); 1.6016 (0.6); 1.5421 (9.7); 1.5253 (10.2); 1.5033 (1.1); 1.3337 (1.7); 1.3148 (1.0); 1.2846 (3.1); 1.2782 (2.7); 1.2753 (3.0); 1.2582 (14.5); 1.2428 BCS241005-Foreign STR 117 (2.0); 0.9413 (0.9); 0.9245 (0.9); 0.8964 (1.4); 0.8816 (3.6); 0.8637 (1.8); 0.8364 (0.5); 0.0707 (6.3); 0.0080 (1.1); -0.0002 (48.8); -0.0085 (2.3) I.1-12: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6466 (2.5); 8.6406 (3.2); 8.5971 (2.9); 8.5910 (2.3); 8.2370 (3.2); 8.2325 (1.2); 8.2203 (1.4); 8.2160 (3.7); 8.0722 (1.8); 8.0053 (1.0); 7.9858 (1.1); 7.7803 (0.9); 7.7578 (4.4); 7.7532 (1.5); 7.7410 (1.4); 7.7367 (3.4); 7.6071 (0.8); 7.5877 (1.4); 7.5684 (0.6); 7.3835 (0.6); 7.3636 (0.6); 7.2612 (13.0); 5.7126 (0.8); 5.6956 (0.9); 5.6763 (0.8); 3.9740 (16.0); 1.5701 (2.0); 1.4330 (5.8); 1.4163 (5.8); 0.0079 (0.6); -0.0002 (14.0); -0.0084 (0.6) I.1-13: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6548 (2.6); 8.6487 (3.4); 8.6031 (3.0); 8.5970 (2.5); 8.2455 (3.4); 8.2407 (1.6); 8.2336 (2.4); 8.2293 (2.5); 8.2245 (4.1); 8.1723 (3.4); 8.1678 (1.3); 8.1557 (1.2); 8.1511 (4.0); 8.0360 (1.9); 7.9864 (1.9); 7.7687 (3.6); 7.7641 (1.4); 7.7521 (1.2); 7.7476 (3.5); 7.7132 (3.7); 7.7086 (1.3); 7.6965 (1.2); 7.6920 (3.5); 7.4179 (0.8); 7.3989 (0.9); 7.2606 (34.7); 5.7345 (0.7); 5.7154 (0.9); 5.6983 (0.8); 3.9759 (16.0); 3.9642 (15.9); 1.5536 (11.0); 1.4584 (5.4); 1.4416 (5.5); 0.0080 (1.1); -0.0002 (37.5); -0.0084 (1.8) I.1-14: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6591 (2.5); 8.6531 (3.1); 8.6041 (2.5); 8.5981 (2.1); 8.2382 (3.0); 8.2334 (1.0); 8.2217 (1.0); 8.2169 (3.4); 8.2126 (0.5); 7.8470 (1.5); 7.7422 (3.3); 7.7373 (1.1); 7.7308 (0.6); 7.7256 (1.6); 7.7209 (3.4); 7.7166 (0.6); 7.7047 (0.6); 7.4860 (0.6); 7.4659 (0.6); 7.2608 (19.5); 5.6906 (0.6); 5.6737 (0.7); 5.6544 (0.6); 3.9758 (16.0); 1.5641 (1.2); 1.4281 (5.1); 1.4114 (5.1); 0.8820 (0.6); 0.0080 (0.8); -0.0002 (28.6); -0.0085 (0.8) I.1-15: 1 H-NMR(400.6 MHz, CDCl3): δ= 8.6636 (2.6); 8.6576 (3.2); 8.6077 (2.5); 8.6016 (2.1); 8.2385 (3.0); 8.2338 (1.0); 8.2220 (1.0); 8.2172 (3.4); 8.2130 (0.6); 8.1187 (1.6); 8.1150 (1.0); 7.9858 (1.6); 7.9842 (1.6); 7.8958 (1.4); 7.8945 (1.4); 7.7458 (3.3); 7.7410 (1.1); 7.7292 (0.9); 7.7244 (3.1); 7.7202 (0.6); 7.3859 (0.5); 7.2616 (9.2); 5.6837 (0.6); 5.6666 (0.7); 5.6645 (0.7); 5.6474 (0.6); 3.9751 (16.0); 1.4354 (5.1); 1.4186 (5.0); 0.8818 (0.6); -0.0002 (13.4) I.1-16: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6521 (2.6); 8.6460 (3.1); 8.5901 (2.5); 8.5841 (2.1); 8.2352 (3.0); 8.2305 (1.0); 8.2188 (1.0); 8.2139 (3.4); 8.2098 (0.6); 8.1397 (1.4); 8.1345 (1.5); 7.9247 (0.8); 7.9197 (0.7); 7.9040 (0.8); 7.8989 (0.8); 7.7448 (3.2); 7.7400 (1.2); 7.7282 (1.0); 7.7235 (3.1); 7.7192 (0.7); 7.6051 (1.4); 7.5844 (1.2); 7.3572 (0.5); 7.2611 (13.6); 5.6909 (0.6); 5.6716 (0.7); 5.6546 (0.6); 3.9739 (16.0); 1.5773 (0.6); 1.4221 (5.2); 1.4053 (5.1); 0.8818 (0.9); 0.0079 (0.5); -0.0002 (19.8); -0.0085 (0.7) I.1-17: 1 H-NMR(400.6 MHz, CDCl3): δ= 8.6586 (2.5); 8.6525 (3.1); 8.5945 (2.4); 8.5884 (2.1); 8.2370 (3.0); 8.2322 (1.0); 8.2205 (1.0); 8.2156 (3.4); 8.2114 (0.6); 7.9369 (1.8); 7.7760 (5.4); 7.7735 (5.5); BCS241005-Ausland STR 118 7.7407 (3.3); 7.7358 (1.1); 7.7241 (1.0); 7.7193 (3.0); 7.7150 (0.6); 7.2605 (29.0); 5.6861 (0.6); 5.6691 (0.7); 5.6498 (0.6); 3.9759 (16.0); 1.5525 (0.9); 1.4209 (5.0); 1.4042 (5.0); 0.0080 (1.1); -0.0002 (42.5); - 0.0085 (1.3) I.1-18:1 H-NMR(400.6 MHz, CDCl3): δ= 9.2077 (0.6); 9.2028 (0.6); 9.0112 (0.5); 9.0078 (0.5); 8.6695 (0.9); 8.6634 (1.1); 8.6025 (0.9); 8.5965 (0.8); 8.3826 (0.6); 8.2443 (1.1); 8.2233 (1.2); 7.7423 (1.2); 7.7213 (1.1); 7.2617 (6.4); 3.9787 (5.4); 2.8085 (16.0); 1.4432 (1.9); 1.4265 (1.9); -0.0002 (9.0) I.1-19: 1 H-NMR(400.6 MHz, CDCl3): δ= 8.8844 (1.4); 8.8720 (1.4); 8.6731 (2.6); 8.6671 (3.0); 8.6018 (2.6); 8.5958 (2.2); 8.2476 (0.5); 8.2433 (3.2); 8.2386 (1.1); 8.2268 (1.1); 8.2221 (3.6); 8.2179 (0.6); 8.0443 (1.9); 7.8626 (1.0); 7.8592 (1.0); 7.8502 (1.0); 7.8469 (1.0); 7.7370 (0.6); 7.7328 (3.5); 7.7280 (1.2); 7.7163 (1.1); 7.7116 (3.3); 7.7073 (0.5); 7.5647 (0.5); 7.5448 (0.5); 7.2621 (11.9); 5.7050 (0.7); 5.6878 (0.8); 5.6689 (0.7); 3.9792 (16.0); 1.5822 (2.4); 1.4350 (5.5); 1.4183 (5.5); -0.0002 (12.3) I.1-20: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.2424 (1.0); 9.2259 (1.0); 8.6905 (2.4); 8.6843 (3.8); 8.6662 (4.3); 8.6602(2.9); 8.0619 (3.4); 8.0573 (1.1); 8.0455 (1.2); 8.0407 (4.1); 8.0366 (0.7); 8.0226 (1.8); 7.9333 (0.7); 7.9096(0.7); 7.8833(0.7); 7.8621(0.7); 7.7931 (0.6); 7.7891 (3.8); 7.7843 (1.2); 7.7725 (1.1); 7.7678 (3.3); 7.7636 (0.5); 5.3526 (0.7); 5.3357 (1.0); 5.3188 (0.7); 3.3218 (16.0); 2.5251 (1.0); 2.5204 (1.4); 2.5116 (20.1); 2.5071 (44.9); 2.5025 (63.3); 2.4979 (44.3); 2.4933 (19.9); 1.9096 (0.6); 1.4929 (4.1); 1.4756 (4.1); 1.2466 (0.9); 0.8579 (1.8); 0.8403 (0.6); 0.0079 (1.1); -0.0002(40.3); - 0.0085 (1.2) I.1-21: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.2730 (1.3); 9.2565 (1.3); 8.6917 (3.0); 8.6856 (4.7); 8.6671(5.3); 8.6609 (3.6); 8.2836 (2.3); 8.1405 (2.1); 8.1390 ​​(2.1); 8.1158 (2.2); 8.1143 (2.1); 8.0668 (0.6); 8.0626 (4.1); 8.0580 (1.4); 8.0462 (1.4); 8.0414 (5.0); 8.0373 (0.8); 7.7903(0.7); 7.7863 (4.6); 7.7815 (1.4); 7.7697 (1.3); 7.7650 (4.1); 7.7608 (0.6); 5.7578 (0.7); 5.3486 (0.8); 5.3318 (1.3); 5.3148 (0.8); 3.3220 (16.0); 2.5253 (1.1); 2.5207 (1.4); 2.5119 (23.4); 2.5073 (52.7); 2.5027 (74.5); 2.4981 (52.4); 2.4936 (23.7); 1.9895 (0.8); 1.9098 (1.0); 1.4907 (4.9); 1.4735 (4.9); 1.2464 (2.0); 0.8747(1.0); 0.8578 (4.2); 0.8402(1.4); 0.0080 (1.3); -0.0002 (49.6); -0.0085 (1.5) I.1-22: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.2498 (1.2); 9.2333 (1.2); 8.6860 (2.8); 8.6798 (4.5); 8.6631 (5.1); 8.6570 (3.4); 8.2180 (1.8); 8.2128 (2.0); 8.1043 (1.0); 8.0994 (0.9); 8.0836 (1.2); 8.0786 (1.1); 8.0656 (0.6); 8.0613 (3.9); 8.0566 (1.3); 8.0449 (1.3); 8.0400 (4.8); 8.0359 (0.7); 7.8185 (1.9); 7.7974 (1.8); 7.7900 (4.5); 7.7852 (1.4); 7.7735 (1.2); 7.7688 (3.8); 7.7646 (0.6); 5.3490 (0.8); 5.3321 (1.2); 5.3151 (0.8); 4.0388 (0.6); 4.0210 (0.6); 3.3234 (16.0); 2.5257 (0.8); 2.5210 (1.1); 2.5123 (18.6); 2.5077 (42.1); 2.5031 (59.8); 2.4985 (42.0); 2.4939 (19.0); 1.9896 (2.6); 1.9102 (1.2); 1.4838 (4.8); BCS241005-Ausland STR 119 1.4666 (4.8); 1.2585 (0.8); 1.2461 (2.1); 1.1931 (0.8); 1.1753 (1.6); 1.1575 (0.8); 0.8746 (1.1); 0.8577 (4.4); 0.8401 (1.5); 0.0080 (1.1); -0.0002 (41.0); -0.0085 (1.2) I.1-23: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1034 (0.6); 9.2401 (1.2); 9.2236 (1.2); 8.6906 (2.8); 8.6844 (4.6); 8.6672(5.3); 8.6611 (3.5); 8.0826 (2.4); 8.0716 (4.1); 8.0669 (1.3); 8.0552 (1.4); 8.0503 (5.0); 8.0462(0.8); 7.9263 (4.1); 7.9199 (2.3); 7.7958 (0.7); 7.7917 (4.6); 7.7869 (1.4); 7.7752 (1.3); 7.7704 (4.0); 7.7663 (0.6); 5.3376 (0.8); 5.3207 (1.2); 5.3037 (0.8); 3.3235 (16.0); 2.5256 (0.9); 2.5209 (1.2); 2.5122 (18.7); 2.5076 (42.1); 2.5030 (59.5); 2.4984 (41.5); 2.4938 (18.5); 1.4832 (4.8); 1.4659 (4.8); 1.2463 (1.3); 0.8746 (0.6); 0.8578 (2.7); 0.8401 (0.9); 0.0080 (1.1); -0.0002 (41.4); -0.0050 (0.6); - 0.0085 (1.2) I.1-24: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.3486 (1.6); 9.3321 (1.7); 9.1805 (2.7); 9.1756 (2.8); 9.1015 (2.1); 9.0993 (2.4); 9.0963 (2.4); 9.0945 (2.1); 8.7023(4.0); 8.6961 (6.2); 8.6769 (7.1); 8.6708 (4.8); 8.5239 (1.6); 8.5203 ​​(2.6); 8.5188 (2.5); 8.5151 (1.5); 8.0696 (0.8); 8.0653 (5.6); 8.0607 (1.8); 8.0489 (1.9); 8.0441 (6.7); 8.0400 (1.0); 7.7993 (1.0); 7.7951 (6.3); 7.7903 (1.9); 7.7786 (1.7); 7.7738 (5.4); 7.7697 (0.8); 5.3818 (1.1); 5.3648 (1.8); 5.3478 (1.1); 3.3272 (16.0); 2.6903 (11.5); 2.5261 (1.1); 2.5214 (1.5); 2.5126 (21.2); 2.5081 (47.4); 2.5035 (66.9); 2.4989 (46.8); 2.4943 (20.9); 1.9898 (0.8); 1.9104 (1.8); 1.5078 (6.8); 1.4906 (6.8); 1.2463(1.0); 0.8745 (0.5); 0.8577 (2.0); 0.8401 (0.7); 0.0080 (1.2); -0.0002(43.7); -0.0085 (1.2) I.1-25: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6984 (0.7); 8.6923 (1.2); 8.6761 (1.3); 8.6700 (0.8); 8.1844 (0.6); 8.0615 (1.0); 8.0403 (1.2); 7.7837 (1.1); 7.7625 (1.0); 5.7571 (0.6); 3.3195 (16.0); 2.5241 (0.7); 2.5194 (1.0); 2.5106 (15.8); 2.5061 (35.2); 2.5014 (49.7); 2.4969 (34.9); 2.4923 (15.7); 1.9888 (0.8); 1.5041 (1.2); 1.4869 (1.2); 1.3552 (1.0); 0.0080 (1.0); -0.0002 (34.0); -0.0085 (1.0) I.1-26: 1 H-NMR(400.6 MHz, CDCl3): δ= 8.6596 (2.5); 8.6535 (3.1); 8.6074 (2.5); 8.6014 (2.0); 8.2384 (3.1); 8.2336 (1.0); 8.2219 (1.0); 8.2170 (3.3); 8.2128 (0.5); 7.9654 (1.5); 7.9614 (1.0); 7.9402 (1.2); 7.9384 (1.5); 7.9367 (1.4); 7.7467 (1.6); 7.7422 (3.9); 7.7373 (1.0); 7.7256 (1.0); 7.7208 (3.0); 7.2611 (16.7); 5.6859 (0.6); 5.6689 (0.7); 5.6497 (0.6); 3.9757 (16.0); 3.9534 (0.7); 1.5875 (0.7); 1.4304 (5.0); 1.4136 (5.0); 0.0080 (0.7); -0.0002 (23.7); -0.0085 (0.6) I.1-27: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6197 (6.0); 8.2200 (1.6); 8.1986 (1.7); 8.1283 (1.4); 8.1250 (1.5); 8.0086 (1.3); 8.0055 (1.3); 7.7349 (1.5); 7.7135 (1.5); 7.5187 (1.7); 7.2989 (0.6); 7.2710 (0.5); 7.2603 (287.6); 7.2330 (1.0); 7.2267 (0.8); 6.9967 (1.7); 4.0972 (1.5); 3.9757 (1.3); 3.9670 (8.0); 3.9618 (1.6); 3.9507 (0.8); 3.4546 (0.5); 2.3575 (1.4); 2.2936 (0.6); 1.6303 (1.9); 1.4803 (1.0); 1.4417 (2.8); 1.4250 (2.9); 1.3328 (2.0); 1.2842 (3.5); 1.2542 (16.0); 1.2325 (4.1); 0.8801 (2.5); 0.8527 (1.7); 0.8352 BCS241005-Foreign STR 120 (1.3); 0.2383 (0.6); 0.1583 (0.9); 0.1455 (1.4); 0.0686 (0.6); 0.0386 (0.5); 0.0295 (0.6); 0.0080 (9.9); - 0.0002 (428.8); -0.0085 (14.1); -0.0274 (1.7); -0.0339 (1.3); -0.0454 (0.8); -0.1493 (1.3) I.1-28: 1H-NMR(400.6 MHz, CDCl3): δ= 8.7805 (1.4); 8.7789 (1.5); 8.7742 (1.5); 8.7726 (1.5); 8.6557 (2.6); 8.6496 (3.1); 8.5825 (2.4); 8.5764 (2.1); 8.2337 (3.0); 8.2289 (1.0); 8.2172 (1.0); 8.2124 (3.3); 8.2082 (0.5); 7.9904 (1.4); 7.9840 (1.4); 7.9697 (1.5); 7.9634 (1.5); 7.7367 (3.2); 7.7319 (1.0); 7.7202 (0.9); 7.7154 (2.9); 7.5937 (1.8); 7.5920 (1.8); 7.5731 (1.6); 7.5714 (1.6); 7.2611 (22.8); 5.6892 (0.6); 5.6722 (0.7); 5.6530 (0.6); 3.9740 (16.0); 2.0455 (0.9); 1.5798 (1.2); 1.4172 (5.0); 1.4005 (5.0); 1.2597 (0.8); 0.8819 (0.8); 0.0080 (0.9); -0.0002 (32.8); -0.0085 (0.9) I.1-29: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.2710 (1.3); 9.2546 (1.4); 8.6927 (3.2); 8.6866 (5.1); 8.6680(5.7); 8.6619(3.9); 8.1428 (2.4); 8.1389 (1.6); 8.0865 (2.4); 8.0850 (2.4); 8.0667 (0.7); 8.0625 (4.6); 8.0579 (1.5); 8.0461 (1.7); 8.0413 (6.8); 8.0369 (2.9); 7.7905 (0.8); 7.7864 (5.0); 7.7816 (1.6); 7.7699 (1.4); 7.7652 (4.4); 7.7610 (0.7); 5.7582 (1.1); 5.3527 (0.9); 5.3358 (1.4); 5.3189 (0.9); 4.0391 (0.6); 4.0214 (0.7); 3.3257 (16.0); 2.5263 (1.0); 2.5217 (1.3); 2.5129 (17.8); 2.5084 (39.6); 2.5037 (55.9); 2.4992 (39.0); 2.4946 (17.4); 1.9900 (3.0); 1.9108 (1.1); 1.4941 (5.4); 1.4769 (5.3); 1.3565 (2.5); 1.2330 (0.5); 1.1934 (1.0); 1.1820 (1.8); 1.1756 (2.1); 1.1702 (0.6); 1.1579 (0.9); 0.0080 (0.7); -0.0002(22.6); - 0.0085 (0.6) I.1-30: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7299 (0.8); 8.7282 (0.9); 8.7236(0.9); 8.7218 (0.9); 8.6873 (1.0); 8.6811 (1.6); 8.6630 (1.9); 8.6569 (1.2); 8.0895 (0.7); 8.0832 (0.7); 8.0689 (1.8); 8.0651 (0.6); 8.0624(0.9); 8.0485 (1.8); 7.7927 (1.6); 7.7880(0.5); 7.7715 (1.4); 7.7466(0.9); 7.7450 (0.9); 7.7258 (0.8); 7.7242 (0.9); 5.7570 (3.1); 4.0379 (0.9); 4.0202 (0.9); 3.3206 (16.0); 2.5243 (0.8); 2.5196 (1.0); 2.5108 (14.4); 2.5063 (32.2); 2.5016 (45.4); 2.4971 (31.6); 2.4925 (14.1); 1.9888 (4.3); 1.9088 (1.0); 1.4694 (1.7); 1.4522 (1.7); 1.3552 (0.5); 1.1923 (1.2); 1.1809 (0.7); 1.1746 (2.5); 1.1568 (1.2); - 0.0002 (17.6) I.1-31: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6755 (2.4); 8.6694 (2.8); 8.5967 (2.3); 8.5906 (2.0); 8.2385 (3.0); 8.2336 (1.0); 8.2220 (1.0); 8.2171 (3.3); 8.2129 (0.5); 7.7183 (3.2); 7.7134 (1.0); 7.7017 (0.9); 7.6969 (3.0); 7.2624 (7.6); 7.1943 (5.4); 5.6679 (0.6); 5.6509 (0.7); 5.6488 (0.7); 5.6319 (0.6); 3.9786 (16.0); 1.4111 (5.1); 1.3944 (5.1); 1.2550 (0.8); -0.0002 (11.8) I.1-32: 1 H-NMR(400.6 MHz, CDCl3): δ= 8.6792 (0.9); 8.6732 (1.1); 8.6608 (2.1); 8.6547 (2.6); 8.6075 (2.4); 8.6014 (2.0); 8.5946 (1.0); 8.5885 (0.9); 8.3039 (1.6); 8.2377 (2.5); 8.2331 (0.9); 8.2220 (1.7); 8.2168 (3.0); 8.2123 (0.5); 8.2018 (1.3); 8.0780 (1.3); 8.0069 (1.3); 7.7452 (2.8); 7.7405 (0.9); 7.7287 (0.9); 7.7241 (2.6); 7.6623 (1.4); 7.6576 (0.5); 7.6413 (1.2); 7.2610 (19.8); 5.6776 (0.6); 5.6605 (0.6); BCS241005-Ausland STR 121 5.6412 (0.6); 3.9744 (16.0); 2.0459 (1.4); 1.4336 (4.3); 1.4169 (4.3); 1.3749 (2.3); 1.3582 (2.3); 1.2598 (0.9); 0.0079 (0.8); -0.0002 (26.0); -0.0085 (0.8) I.1-33: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6513 (2.5); 8.6452 (3.2); 8.6028 (2.6); 8.5967 (2.0); 8.2319 (3.1); 8.2271 (1.0); 8.2154 (1.0); 8.2106 (3.3); 8.2063 (0.5); 7.7394 (0.5); 7.7352 (3.4); 7.7304 (1.0); 7.7186 (1.0); 7.7138 (3.0); 7.6717 (6.1); 7.6670 (6.4); 7.4993 (1.6); 7.4946 (2.9); 7.4898 (1.4); 7.2605 (32.6); 5.6605 (0.6); 5.6436 (0.7); 5.6242 (0.6); 5.3001 (1.1); 3.9737 (16.0); 1.5529 (3.1); 1.4093 (5.1); 1.3926 (5.1); 0.0079 (1.4); -0.0002 (51.1); -0.0085 (1.4) I.1-34: 1 H-NMR(400.6 MHz, CDCl3): δ= 8.8155 (1.0); 8.8112 (1.7); 8.8069 (1.0); 8.6794 (2.6); 8.6733 (3.1); 8.6260 (1.5); 8.6222 (1.0); 8.6176 (2.7); 8.6115 (2.1); 8.4428 (1.6); 8.4414 (1.6); 8.2504 (0.5); 8.2461 (3.2); 8.2413 (1.0); 8.2296 (1.1); 8.2247 (3.5); 8.2206 (0.5); 7.7498 (0.6); 7.7456 (3.4); 7.7408 (1.1); 7.7291 (1.0); 7.7243 (3.1); 7.5995 (0.6); 7.5802 (0.6); 7.2649 (5.2); 5.7190 (0.6); 5.7017 (0.8); 5.6830 (0.6); 5.3006 (10.6); 3.9802 (16.0); 1.6642 (0.6); 1.4618 (5.1); 1.4451 (5.0); -0.0002 (5.9) I.1-35:1 H-NMR(400.6 MHz, d6-DMSO): δ= 8.6892 (0.7); 8.6671(0.8); 8.6610(0.6); 8.0712 (0.6); 8.0499 (0.8); 7.7976(0.7); 7.7762 (0.7); 3.8920 (2.9); 3.3192(16.0); 2.5194 (0.6); 2.5106 (8.8); 2.5060 (19.6); 2.5014 (27.9); 2.4968 (19.6); 2.4922 (9.0); 1.4818 (0.8); 1.4646 (0.8); 0.0079(0.8); -0.0002(29.7); -0.0044 (0.5); -0.0085 (0.9) I.1-36: 1 H-NMR(400.6 MHz, d6-DMSO): δ= 9.1836 (0.7); 9.1672 (0.8); 8.6881 (1.7); 8.6820 (2.8); 8.6639 (3.2); 8.6578 (2.2); 8.0628 (2.5); 8.0581 (0.8); 8.0464 (0.9); 8.0416 (3.0); 7.9491 (1.2); 7.9449 (1.7); 7.9409 (1.3); 7.7816 (2.7); 7.7768 (0.9); 7.7651(0.8); 7.7604 (2.5); 7.7549 (0.7); 7.7524 (0.7); 7.7490 (1.1); 7.7447 (0.8); 7.7425 (0.7); 7.7151 (1.1); 7.7122 (1.2); 7.7096 (0.9); 5.3129 (0.8); 3.3216 (16.0); 2.5248 (1.0); 2.5201 (1.3); 2.5113 (18.9); 2.5068 (41.9); 2.5022 (58.9); 2.4976 (41.2); 2.4930 (18.8); 1.9891 (0.9); 1.4783 (2.9); 1.4611 (2.9); 1.3556 (1.2); 1.1749 (0.6); 0.0080 (1.4); -0.0002(47.9); - 0.0085 (1.4) I.1-37:1 H-NMR(400.6 MHz, CDCl3): δ= 8.8179 (0.9); 8.8135 (1.5); 8.8093 (0.9); 8.6789 (2.3); 8.6728 (2.8); 8.6265 (1.3); 8.6227 (0.9); 8.6159 (2.4); 8.6099 (2.0); 8.4442 (1.4); 8.4429 (1.4); 8.2465 (3.0); 8.2416 (1.0); 8.2300 (1.0); 8.2251 (3.3); 8.2209 (0.6); 7.7495 (0.5); 7.7453 (3.2); 7.7405 (1.0); 7.7288 (1.0); 7.7240 (2.9); 7.7198 (0.5); 7.2647 (5.2); 5.7203 (0.6); 5.7031 (0.7); 5.7015 (0.7); 5.6843 (0.6); 5.3007 (5.7); 3.9803 (16.0); 1.6563 (0.6); 1.4619 (4.7); 1.4451 (4.7); -0.0002 (6.8) I.1-38: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6681 (2.5); 8.6620 (3.0); 8.6076 (2.5); 8.6015 (2.1); 8.5083 (1.8); 8.3789 (1.6); 8.3406 (1.5); 8.3392 (1.6); 8.2452 (2.9); 8.2405 (1.0); 8.2287 (1.0); 8.2239 (3.5); 8.2198 (0.5); 7.7493 (0.5); 7.7451 (3.2); 7.7403 (1.0); 7.7285 (0.9); 7.7238 (3.2); 7.4964 (0.6); 7.4773 BCS241005-Foreign STR 122 (0.6); 7.2620 (20.1); 5.7106 (0.6); 5.6919 (0.8); 5.6747 (0.6); 4.1486 (1.1); 4.1308 (3.4); 4.1130 (3.4); 4.0951 (1.1); 3.9786 (15.1); 3.1441 (14.4); 2.0455 (16.0); 1.5789 (11.7); 1.4554 (4.9); 1.4386 (4.8); 1.2774 (4.4); 1.2596 (8.8); 1.2418 (4.2); 0.0079 (0.7); -0.0002 (22.3); -0.0085 (0.6) I.1-39: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6586 (2.5); 8.6525 (3.0); 8.6011 (2.4); 8.5950 (2.0); 8.2368 (3.0); 8.2320 (1.0); 8.2203 (1.0); 8.2154 (3.3); 7.7378 (3.2); 7.7330 (1.0); 7.7213 (0.9); 7.7165 (2.9); 7.6043 (2.4); 7.5990 (2.4); 7.2613 (16.3); 7.2469 (0.9); 7.2447 (1.0); 7.2424 (0.9); 5.6786 (0.6); 5.6616 (0.7); 5.6425 (0.6); 3.9751 (16.0); 1.5710 (7.7); 1.4210 (4.8); 1.4042 (4.8); -0.0002 (18.4); -0.0085 (0.5) I.1-40: 1 H-NMR(400.6 MHz, CDCl3): δ= 8.6579 (0.7); 8.6518 (0.8); 8.6044 (0.6); 8.5984 (0.5); 8.2388 (0.8); 8.2173 (0.9); 7.7450 (0.9); 7.7236 (0.8); 7.2604 (24.9); 6.6042 (0.7); 3.9755 (4.4); 1.5443 (16.0); 1.4333 (1.2); 1.4166 (1.2); 0.0080 (0.8); -0.0002 (28.6); -0.0085 (0.8) I.1-41: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6656 (0.9); 8.6595 (1.1); 8.6107 (0.9); 8.6046 (0.7); 8.2481 (1.1); 8.2247 (1.1); 8.2033 (1.2); 7.7448 (1.2); 7.7235 (1.0); 7.2607 (20.3); 4.6543 (1.1); 4.6385 (0.5); 4.2259 (1.4); 4.2080 (1.4); 2.8377 (0.6); 2.8219 (1.4); 2.8060 (0.6); 1.5514 (16.0); 1.4486 (1.6); 1.4319 (1.6); 1.3082 (1.7); 1.2904 (3.6); 1.2725 (1.9); 1.2657 (0.6); 0.8820 (1.1); 0.0080 (0.7); -0.0002 (22.6); - 0.0085 (0.7) I.1-43: 1H-NMR(400.6 MHz, CDCl3): δ= 9.2204 (3.5); 9.2162 (3.7); 9.2081 (3.6); 9.2039 (3.6); 8.6754 (8.2); 8.6693 (10.3); 8.6230 (8.7); 8.6169 (7.0); 8.3082 (10.0); 8.3035 (3.6); 8.2916 (3.7); 8.2868 (11.2); 8.2473 (11.3); 8.0206 (5.0); 7.7853 (10.7); 7.7806 (3.8); 7.7687 (3.5); 7.7640 (10.1); 7.7156 (3.2); 7.7114 (3.3); 7.6944 (4.4); 7.6902 (4.4); 7.5812 (4.7); 7.5688 (4.7); 7.5601 (3.6); 7.5477 (3.5); 7.5204 (0.5); 7.4713 (2.0); 7.4522 (2.1); 7.2620 (82.0); 5.8201 (0.8); 5.7861 (11.7); 5.7813 (11.8); 5.7471 (0.8); 5.7223 (0.6); 5.7057 (2.1); 5.6867 (2.6); 5.6695 (2.1); 5.6528 (0.6); 5.3005 (15.1); 4.1490 (0.5); 4.1311 (1.7); 4.1132 (1.7); 4.0954 (0.6); 2.1802 (0.5); 2.1325 (2.4); 2.1042 (1.8); 2.0458 (8.4); 1.5832 (10.8); 1.4609 (16.0); 1.4442 (16.0); 1.4242 (1.4); 1.3333 (0.7); 1.2845 (1.2); 1.2776 (2.7); 1.2597 (6.0); 1.2419 (2.4); 0.8802 (0.6); 0.0079 (3.0); -0.0002 (87.8); -0.0085 (2.9) I.1-44: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6851 (6.5); 8.6791 (8.9); 8.6256 (7.3); 8.6194 (7.2); 8.2802 (8.9); 8.2591 (9.9); 7.9074 (6.4); 7.7977 (5.4); 7.7828 (10.2); 7.7616 (9.5); 7.5540 (2.6); 7.5342 (8.0); 7.2626 (78.6); 7.2605 (183.6); 6.9969 (1.2); 6.7972 (3.5); 6.6165 (7.1); 6.4358 (3.5); 5.7356 (2.1); 5.7162 (2.9); 5.6994 (2.3); 2.1271 (1.6); 1.4847 (15.6); 1.4680 (16.0); 1.4322 (3.3); 1.2561 (4.0); 0.1458 (1.0); 0.0079 (3.8); 0.0020 (87.7); -0.0002 (209.3); -0.1489 (1.4) BCS241005-Abroad STR 123 I.1-45: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6850 (8.1); 8.6789 (10.1); 8.6223 (8.7); 8.6162 (7.5); 8.2793 (9.8); 8.2582 (11.0); 7.7752 (10.5); 7.7585 (3.4); 7.7541 (9.7); 7.6315 (9.4); 7.6264 (9.7); 7.5190 (2.5); 7.5030 (2.5); 7.2915 (0.5); 7.2604 (210.9); 6.9968 (1.2); 5.7366 (0.6); 5.7197 (2.0); 5.7017 (2.7); 5.6837 (2.2); 5.6665 (0.6); 4.1496 (0.8); 4.1317 (2.1); 4.1140 (2.2); 4.0961 (0.6); 2.1289 (1.9); 2.0464 (9.6); 1.4700 (16.0); 1.4532 (15.9); 1.2843 (1.2); 1.2779 (3.3); 1.2600 (8.3); 1.2422 (3.4); 0.8803 (1.0); 0.1458 (0.8); 0.0307 (0.7); 0.0148 (0.8); 0.0078 (7.1); -0.0002 (234.7); -0.0085 (8.2); -0.0284 (0.8); -0.1494 (0.9) I.1-46: 1H-NMR(400.6 MHz, CDCl3): δ= 8.7002 (2.8); 8.6941 (3.5); 8.6281 (2.9); 8.6219 (2.5); 8.5479 (2.1); 8.4075 (1.8); 8.3464 (1.8); 8.2973 (3.2); 8.2927 (1.1); 8.2808 (1.1); 8.2761 (3.8); 7.7918 (3.4); 7.7873 (1.2); 7.7707 (3.4); 7.7070 (0.8); 7.6873 (0.9); 7.2607 (68.4); 5.7465 (0.7); 5.7277 (0.8); 5.7100 (0.6); 5.3003 (2.6); 3.1472 (16.0); 2.1307 (1.6); 2.0465 (1.4); 1.5112 (5.0); 1.4944 (5.1); 1.2844 (0.6); 1.2779 (0.7); 1.2599 (2.2); 1.2560 (2.2); 1.2422 (0.7); 0.0080 (2.2); -0.0002 (78.6); -0.0085 (2.5) I.1-47: 1 H-NMR(400.6 MHz, CDCl3): δ= 8.6714 (0.6); 8.2739 (0.5); 8.2525 (0.7); 8.2454 (0.5); 7.8147 (0.6); 7.7932 (0.5); 7.2606 (21.8); 5.0259 (1.9); 3.8280 (0.5); 3.7585 (1.4); 3.7425 (1.4); 1.5463 (16.0); 1.4656 (0.8); 1.4488 (0.8); 0.0079 (0.7); -0.0002 (23.5); -0.0085 (0.6) I.1-48: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.3019 (0.6); 9.2854 (0.6); 8.7048 (1.5); 8.6987 (2.2); 8.6734 (2.6); 8.6673 (1.9); 8.2542 (1.0); 8.2504 (2.0); 8.2465 (1.2); 8.1621 (1.0); 8.1573 (1.5); 8.1534 (1.1); 8.1120 (1.3); 8.1077 (1.6); 8.1030 (1.0); 8.0844 (2.1); 8.0797 (0.6); 8.0680(0.7); 8.0630 (2.5); 7.8126 (2.4); 7.8077 (0.7); 7.7960 (0.7); 7.7912 (2.1); 5.7573 (2.6); 5.3277 (0.6); 3.8966 (9.2); 3.3198 (16.0); 3.3095 (8.5); 3.2505 (0.5); 2.5243 (0.8); 2.5196 (1.2); 2.5109 (15.6); 2.5063 (33.7); 2.5017 (47.0); 2.4971 (31.9); 2.4926 (13.7); 1.9888 (1.9); 1.4992 (2.4); 1.4819 (2.3); 1.1924 (0.5); 1.1746 (1.0); 0.0081 (1.3); -0.0002(49.1); -0.0085 (1.3) I.1-49: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.4275 (2.5); 9.4109 (2.5); 8.7003 (5.8); 8.6942 (9.2); 8.6760 (10.4); 8.6699 (6.8); 8.4522 (0.7); 8.4343 (8.5); 8.2817 (3.8); 8.0586 (1.2); 8.0545 (8.2); 8.0498 (2.6); 8.0380 (2.9); 8.0332 (9.8); 8.0291 (1.4); 7.7938 (1.5); 7.7897 (9.3); 7.7850 (2.8); 7.7732 (2.7); 7.7685 (8.0); 7.7643 (1.2); 7.6295 (0.8); 7.6265 (0.5); 7.6177 (0.5); 7.6005 (0.6); 7.5680 (0.6); 5.3945 (1.6); 5.3775 (2.5); 5.3605 (1.6); 4.0395 (1.0); 4.0217 (1.0); 2.9979 (1.2); 2.6731 (0.6); 2.5436 (0.8); 2.5269 (1.5); 2.5222 (2.1); 2.5135 (35.2); 2.5089 (77.7); 2.5043 (108.6); 2.4997 (74.5); 2.4952 (32.8); 2.3314 (0.6); 1.9947 (1.3); 1.9902 (4.6); 1.9110 (16.0); 1.5201 (9.8); 1.5029 (9.7); 1.2592 (0.7); 1.2329 (2.9); 1.1938 (1.7); 1.1760 (3.2); 1.1582 (1.5); 0.8855 (0.6); 0.8773 (0.8); 0.8720 (0.6); 0.8587 (0.5); 0.8530 (0.7); 0.0079 (2.7); 0.0062 (0.7); 0.0053 (0.9); 0.0045 (1.2); -0.0002 (102.2); -0.0052 (1.3); - 0.0060 (1.1); -0.0069 (1.0); -0.0085 (3.0) BCS241005-Ausland STR 124 I.1-50:. 1H-NMR(400.6 MHz, CDCl3): δ= 8.6961 (6.5); 8.6900 (7.6); 8.6162 (6.6); 8.6101 (5.7); 8.3084 (0.7); 8.2923 (14.5); 8.2757 (3.0); 8.2710 (7.6); 8.0155 (4.0); 7.7810 (7.9); 7.7761 (4.0); 7.7644 (3.0); 7.7598 (7.7); 7.7553 (3.2); 7.7178 (1.4); 7.7135 (8.9); 7.7103 (11.9); 7.7067 (5.1); 7.6982 (3.6); 7.6931 (16.0); 7.6894 (13.6); 7.6834 (9.1); 7.6801 (11.7); 7.6766 (5.1); 7.6681 (3.6); 7.6629 (15.7); 7.6593 (13.3); 7.5800 (1.5); 7.5764 (3.5); 7.5727 (3.5); 7.5691 (1.7); 7.5640 (2.1); 7.5583 (7.4); 7.5540 (7.4); 7.5486 (2.6); 7.5430 (4.2); 7.5394 (9.1); 7.5356 (8.4); 7.5319 (3.1); 7.4955 (8.0); 7.4938 (10.5); 7.4906 (7.0); 7.4882 (8.7); 7.4865 (10.5); 7.4831 (4.8); 7.4783 (8.6); 7.4749 (15.0); 7.4709 (11.5); 7.4675 (14.4); 7.4636 (4.1); 7.4610 (3.0); 7.4572 (6.6); 7.4541 (5.0); 7.4498 (6.2); 7.4470 (3.7); 7.2617 (58.6); 7.2573 (0.8); 7.2566 (0.8); 7.2550 (0.6); 6.2770 (1.0); 6.2629 (1.0); 5.7464 (1.4); 5.7290 (1.8); 5.7105 (1.5); 2.1115 (8.1); 2.0471 (0.5); 1.6441 (0.9); 1.6272 (0.9); 1.5988 (0.7); 1.5960 (0.7); 1.5847 (0.7); 1.5820 (0.7); 1.5011 (10.6); 1.4843 (10.8); 1.4615 (0.7); 1.4208 (4.6); 1.4066 (4.7); 1.3341 (2.9); 1.2846 (4.4); 1.2777 (1.5); 1.2560 (7.2); 1.2373 (1.3); 1.2332 (0.9); 1.1803 (1.2); 1.1644 (1.2); 1.0010 (0.5); 0.9826 (0.6); 0.8968 (0.8); 0.8802 (2.0); 0.8626 (0.9); 0.0080 (1.8); -0.0002 (66.2); -0.0085 (1.9) I.1-51:. 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.3193 (0.7); 9.3029 (0.7); 8.6974 (1.7); 8.6913 (2.5); 8.6700 (3.0); 8.6640 (2.1); 8.2756 (1.2); 8.2717 (2.3); 8.2678 (1.3); 8.1849 (1.2); 8.1801 (1.6); 8.1762 (1.2); 8.1119 (1.4); 8.1077 (1.8); 8.1030 (1.2); 8.0725 (2.3); 8.0678 (0.7); 8.0560 (0.8); 8.0512 (2.8); 7.7956 (2.5); 7.7908 (0.8); 7.7791 (0.7); 7.7743 (2.2); 5.3309 (0.7); 3.3422 (16.0); 3.3113 (9.8); 2.6703 (0.6); 2.5408 (0.8); 2.5240 (1.4); 2.5194 (2.1); 2.5106 (30.0); 2.5061 (65.4); 2.5015 (91.5); 2.4968 (62.5); 2.4923 (27.0); 2.3285 (0.5); 1.4953 (2.6); 1.4781 (2.6); 0.0080 (1.5); -0.0002(58.0); -0.0028 (1.9); - 0.0044 (0.6); -0.0085 (1.6) I.1-52: 1 H-NMR(400.6 MHz, d6-DMSO): δ= 8.6871 (0.6); 8.6810 (1.0); 8.6606 (1.2); 8.6545 (0.8); 8.0846 (0.9); 8.0632 (1.1); 7.8242(1.0); 7.8028(0.9); 7.5688(0.5); 3.8939 (4.1); 3.3219(16.0); 2.5113 (6.1); 2.5067(13.5); 2.5021(19.0); 2.4975 (13.1); 2.4929 (5.7); 1.4718 (1.1); 1.4546 (1.1); -0.0002 (8.6) I.1-53: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.9710 (0.8); 8.9668 (0.7); 8.7051 (0.7); 8.6990 (1.1); 8.6766 (1.3); 8.6705 (0.9); 8.0791 (1.0); 8.0577 (1.3); 7.8137 (1.2); 7.7923 (1.0); 3.8913 (4.7); 3.3220 (16.0); 2.5201 (0.6); 2.5114 (6.9); 2.5068 (14.7); 2.5023 (20.3); 2.4976 (13.9); 2.4931 (6.0); 1.9892 (1.1); 1.4981 (1.3); 1.4809 (1.2); 1.1749 (0.6); -0.0002 (8.9) I.1-54: 1 H-NMR(400.6 MHz, d6-DMSO): δ= 8.6794 (0.9); 8.6733 (1.5); 8.6568 (1.8); 8.6507 (1.1); 8.0708 (1.3); 8.0495 (1.6); 7.8500 (0.5); 7.8025 (1.5); 7.7812 (1.3); 7.5732 (0.8); 7.5541 (0.6); 3.3226 (16.0); 2.5244 (0.7); 2.5197 (1.0); 2.5110 (14.9); 2.5064 (32.9); 2.5018 (46.2); 2.4972 (31.6); 2.4926 (13.7); 1.9888 (2.4); 1.4688 (1.6); 1.4516 (1.6); 1.1924 (0.7); 1.1746 (1.5); 1.1568 (0.7); 0.0080 (1.4); - 0.0002 (50.4); -0.0029 (1.2); -0.0085 (1.3) BCS241005-Ausland STR 125 I.1-55: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.2846 (0.7); 9.2680 (0.7); 8.9804 (1.7); 8.9762 (1.7); 8.8089(0.9); 8.8023(0.9); 8.6977 (1.6); 8.6916 (2.6); 8.6730 (3.0); 8.6669 (2.0); 8.1721 (0.5); 8.1696 (0.7); 8.1676 (0.8); 8.1653 (1.0); 8.1630 (0.8); 8.1610 (0.6); 8.0645 (2.3); 8.0598 (0.7); 8.0481 (0.8); 8.0432 (2.8); 7.7912 (2.6); 7.7864 (0.8); 7.7747 (0.7); 7.7699 (2.2); 5.3468 (0.7); 3.3221 (16.0); 2.5247 (1.0); 2.5201 (1.4); 2.5113 (18.6); 2.5068 (40.4); 2.5022 (56.4); 2.4976 (38.5); 2.4930 (16.5); 2.1234 (1.0); 1.9891 (2.1); 1.9093 (0.6); 1.4956 (2.7); 1.4784 (2.7); 1.1926 (0.6); 1.1749 (1.2); 1.1571 (0.6); 0.0080 (2.0); 0.0066 (0.6); 0.0057 (0.6); 0.0048 (0.8); -0.0002(71.2); -0.0085 (1.8) I.1-56: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6866 (8.8); 8.6805 (10.5); 8.6217 (8.6); 8.6157 (7.1); 8.3725 (1.6); 8.2859 (9.7); 8.2812 (3.2); 8.2693 (3.3); 8.2646 (11.1); 8.2256 (1.5); 8.1137 (4.0); 8.1093 (5.7); 8.1052 (4.2); 7.9821 (1.1); 7.9774 (2.2); 7.9352 (5.6); 7.8909 (5.0); 7.8861 (8.1); 7.8813 (3.9); 7.7813 (10.3); 7.7765 (3.2); 7.7600 (9.7); 7.5190 (3.1); 7.5011 (2.0); 7.4806 (2.2); 7.3102 (0.8); 7.2989 (0.8); 7.2900 (1.0); 7.2836 (1.0); 7.2605 (528.8); 7.2572 (11.0); 7.2548 (3.2); 7.2539 (2.9); 7.2532 (2.3); 7.2523 (2.0); 7.2515 (1.8); 7.2492 (1.4); 7.2476 (1.2); 7.2350 (1.2); 7.2292 (1.3); 6.9968 (3.0); 5.7070 (1.9); 5.6882 (2.4); 5.6712 (2.0); 1.6119 (1.8); 1.4717 (16.0); 1.4550 (15.8); 1.3329 (4.2); 1.2842 (5.7); 1.2563 (3.7); 1.1410 (1.5); 1.1254 (1.6); 0.8803 (1.1); 0.1458 (1.8); 0.0382 (0.8); 0.0295 (1.2); 0.0137 (0.9); 0.0121 (1.2); 0.0113 (1.3); 0.0105 (1.8); 0.0096 (2.6); 0.0080 (17.0); 0.0057 (6.6); 0.0049 (8.5); 0.0041 (11.0); -0.0002 (612.8); -0.0057 (6.3); -0.0066 (6.0); -0.0085 (16.8); -0.0129 (2.4); -0.0153 (1.6); -0.0185 (1.2); -0.0217 (1.1); -0.0256 (1.7); -0.0317 (1.5); -0.0502 (0.8); -0.1497 (1.7) I.1-57:. 1 H-NMR(400.6 MHz, CDCl3): δ= 8.6675 (2.0); 8.6614 (2.5); 8.6101 (2.0); 8.6040 (1.7); 8.2735 (2.4); 8.2687 (0.8); 8.2521 (4.8); 8.0189 (1.0); 7.7500 (2.5); 7.7452 (0.8); 7.7335 (0.8); 7.7287 (2.3); 7.2616 (14.1); 5.6957 (0.6); 5.3002 (3.1); 4.5454 (0.9); 4.5434 (1.0); 4.5357 (1.1); 4.5342 (1.1); 4.5313 (1.0); 4.5292 (1.0); 4.5216 (1.1); 4.5201 (1.0); 3.7791 (1.6); 3.7695 (1.1); 3.7672 (1.7); 3.7555 (1.6); 3.4605 (16.0); 1.5765 (9.2); 1.4446 (3.7); 1.4279 (3.7); -0.0002 (15.2) I.1-58: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6736 (8.7); 8.6675 (10.8); 8.6173 (8.5); 8.6112 (7.0); 8.2721 (1.8); 8.2679 (10.8); 8.2630 (4.1); 8.2530 (10.6); 8.2518 (10.6); 8.2465 (12.4); 8.2423 (1.8); 8.0229 (4.4); 7.7852 (1.8); 7.7810 (11.2); 7.7762 (3.4); 7.7644 (3.3); 7.7596 (10.4); 7.7554 (1.5); 7.4576 (1.7); 7.4375 (1.8); 7.2614 (73.8); 6.9978 (0.5); 5.7313 (2.0); 5.7143 (2.4); 5.6951 (2.0); 5.6784 (0.5); 5.3002 (8.1); 2.7731 (2.1); 2.7607 (2.1); 2.7547 (5.3); 2.7399 (1.7); 2.7351 (2.1); 2.6850 (1.8); 2.6814 (1.9); 2.6667 (5.7); 2.6489 (2.2); 2.2473 (0.7); 2.1949 (1.2); 2.0455 (1.7); 1.9153 (2.0); 1.9089 (2.2); 1.8996 (6.1); 1.8963 (5.7); 1.8902 (7.7); 1.8841 (6.1); 1.8808 (6.0); 1.8714 (2.5); 1.8655 (2.0); 1.5784 (3.8); 1.4622 (15.9); 1.4455 (16.0); 1.3012 (0.6); 1.2825 (0.9); 1.2774 (1.2); 1.2636 (2.3); 1.2597 (2.5); 1.2418 (0.8); 0.8988 (1.2); 0.8819 (4.5); 0.8642 (1.6); 0.0079 (3.4); -0.0002 (117.3); -0.0060 (0.7); -0.0069 (0.6); - 0.0085 (3.2) BCS241005-Abroad STR 126 I.1-59: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6637 (2.5); 8.6577 (3.1); 8.6043 (2.9); 8.5981 (2.4); 8.2385 (3.2); 8.2343 (1.0); 8.2224 (1.1); 8.2179 (3.8); 8.2136 (0.6); 8.1390 (1.2); 8.1347 (2.0); 8.1307 (1.4); 8.0553 (2.0); 8.0269 (1.5); 8.0222 (2.3); 8.0177 (1.1); 7.7385 (3.4); 7.7342 (1.1); 7.7224 (1.0); 7.7179 (3.4); 7.7135 (0.5); 7.3628 (0.6); 7.3429 (0.6); 7.2607 (29.2); 5.6762 (0.7); 5.6586 (0.8); 5.6403 (0.7); 3.9755 (16.0); 1.5645 (1.4); 1.4321 (5.5); 1.4154 (5.5); 1.2640 (0.8); 0.8818 (1.4); 0.8639 (0.6); 0.0078 (1.0); -0.0002 (38.6); -0.0085 (1.1) I.1-60: 1H-NMR(400.6 MHz, CDCl3): δ= 8.7007 (8.0); 8.6946 (9.5); 8.6246 (9.0); 8.6184 (7.9); 8.2873 (9.8); 8.2708 (3.4); 8.2663 (11.7); 8.1641 (3.9); 8.1597 (6.4); 8.1557 (4.7); 8.0913 (6.3); 8.0335 (4.8); 8.0289 (7.7); 8.0243 (4.0); 7.7848 (10.7); 7.7804 (3.4); 7.7639 (10.4); 7.5324 (2.2); 7.5184 (2.2); 7.5128 (2.4); 7.2600 (272.6); 7.2299 (0.9); 6.9965 (1.6); 5.7274 (0.6); 5.7113 (2.2); 5.6934 (2.7); 5.6752 (2.2); 5.3000 (7.3); 4.1495 (0.6); 4.1315 (1.3); 4.1136 (1.2); 2.1267 (2.8); 2.0461 (6.3); 1.4848 (15.9); 1.4680 (16.0); 1.4322 (1.1); 1.3326 (1.9); 1.2840 (3.0); 1.2778 (3.1); 1.2560 (11.5); 1.2421 (3.3); 1.2229 (1.8); 0.8800 (2.2); 0.8625 (1.3); 0.1593 (0.6); 0.1456 (1.5); 0.0690 (0.8); 0.0079 (10.0); -0.0002 (388.5); - 0.0085 (12.3); -0.0305 (1.2); -0.1497 (1.4) I.1-61: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6691 (3.9); 8.6630 (4.7); 8.6106 (3.8); 8.6044 (3.1); 8.2755 (0.8); 8.2714 (4.8); 8.2665 (1.6); 8.2499 (9.8); 8.0195 (2.1); 7.7544 (0.9); 7.7502 (5.1); 7.7454 (1.6); 7.7336 (1.6); 7.7289 (4.7); 7.7246 (0.7); 7.4570 (0.8); 7.4378 (0.8); 7.2610 (43.8); 5.7170 (0.9); 5.6999 (1.1); 5.6808 (0.9); 5.3002 (4.4); 4.5397 (1.8); 4.5376 (1.8); 4.5295 (2.3); 4.5281 (2.2); 4.5252 (2.1); 4.5233 (2.1); 4.5153 (2.0); 4.5136 (1.9); 4.1310 (0.5); 4.1132 (0.5); 3.8180 (3.1); 3.8118 (1.0); 3.8079 (2.4); 3.8058 (3.4); 3.8001 (0.9); 3.7938 (2.9); 3.6407 (2.2); 3.6231 (7.2); 3.6057 (7.3); 3.5882 (2.3); 2.1286 (1.2); 2.0456 (2.6); 1.5720 (2.4); 1.4595 (0.6); 1.4487 (7.4); 1.4320 (7.4); 1.2764 (7.6); 1.2589 (16.0); 1.2414 (7.7); 0.0080 (2.2); 0.0064 (0.9); 0.0056 (1.1); -0.0002 (64.3); -0.0050 (0.6); -0.0085 (1.6) I.1-62: 1H-NMR(400.6 MHz, CDCl3): δ= 8.7655 (2.9); 8.7612 (2.9); 8.6667 (6.8); 8.6607 (8.4); 8.6423 (2.3); 8.6382 (2.3); 8.6302 (2.4); 8.6260 (2.3); 8.6127 (6.5); 8.6066 (5.2); 8.2709 (1.3); 8.2667 (8.1); 8.2619 (2.4); 8.2453 (15.2); 8.2418 (7.5); 8.0154 (3.2); 7.8569 (1.3); 7.8525 (1.9); 7.8514 (1.8); 7.8470 (1.2); 7.8372 (1.4); 7.8330 (2.0); 7.8317 (1.9); 7.8274 (1.3); 7.7678 (1.4); 7.7636 (8.4); 7.7587 (2.4); 7.7470 (2.5); 7.7422 (7.5); 7.7379 (1.1); 7.4646 (1.3); 7.4450 (1.3); 7.3878 (1.8); 7.3857 (1.7); 7.3756 (1.8); 7.3736 (1.7); 7.3682 (1.7); 7.3662 (1.6); 7.3560 (1.7); 7.3540 (1.5); 7.2622 (30.9); 5.6977 (1.5); 5.6806 (1.7); 5.6785 (1.6); 5.6614 (1.4); 5.4432 (12.8); 5.2997 (10.1); 4.1488 (0.7); 4.1310 (2.1); 4.1131 (2.1); 4.0953 (0.7); 2.2616 (0.8); 2.2477 (1.1); 2.1948 (2.0); 2.1035 (1.7); 2.0455 (10.3); 1.4494 (11.6); 1.4326 (11.5); 1.3214 (0.7); 1.3036 (1.6); 1.2907 (1.8); 1.2861 (2.0); 1.2832 (2.0); 1.2773 (5.2); 1.2645 (7.8); 1.2595 (11.0); 1.2447 (1.5); 1.2416 (3.9); 1.2273 (0.5); 0.8988 (4.2); 0.8819 (16.0); 0.8642 (5.8); 0.0080 (1.4); -0.0002 (48.9); -0.0085 (1.2) BCS241005-Ausland STR 127 I.1-63:. 1 H-NMR(400.6 MHz, CDCl3): δ= 8.6784 (1.4); 8.6723 (1.7); 8.6356 (1.0); 8.6326 (1.9); 8.6290 (4.4); 8.6258 (1.4); 8.6078 (1.4); 8.6016 (1.2); 8.5325 (0.6); 8.2478 (1.7); 8.2313 (2.0); 8.2267 (2.9); 7.7421 (1.8); 7.7373 (0.6); 7.7208 (1.8); 7.5187 (0.6); 7.2603 (92.0); 4.1309 (0.5); 4.1131 (0.6); 3.9803 (8.8); 3.1604 (16.0); 3.1378 (6.6); 2.0454 (2.6); 1.5493 (6.3); 1.4618 (2.6); 1.4450 (2.6); 1.2842 (0.6); 1.2775 (0.9); 1.2596 (1.9); 1.2418 (0.7); 0.0079 (3.6); -0.0002 (139.8); -0.0085 (4.0) I.1-64: 1H-NMR(600.3 MHz, CDCl3): δ= 8.6238 (1.4); 8.6197 (1.6); 8.5784 (1.5); 8.5745 (1.3); 8.2176 (2.0); 8.2038 (2.1); 7.7445 (2.0); 7.7307 (1.9); 7.6441 (1.5); 7.6418 (1.5); 7.4422 (0.7); 7.4395 (0.7); 7.4287 (0.8); 7.4260 (0.8); 7.2601 (36.6); 7.2488 (1.4); 7.2353 (1.2); 7.2114 (0.4); 7.1981 (0.4); 5.6568 (0.4); 5.6447 (0.6); 5.6327 (0.4); 4.5458 (5.7); 3.9680 (8.3); 3.2126 (0.4); 3.2088 (0.4); 1.5577 (2.2); 1.4004 (0.4); 1.3883 (3.3); 1.3771 (3.1); 1.3598 (0.3); 1.2529 (0.8); -0.0001 (50.0); -0.0055 (2.4) I.1-64: 1 H-NMR(400.6 MHz, CDCl3): δ= 8.6216 (3.8); 8.5759 (3.6); 8.2197 (4.1); 8.2015 (4.7); 7.7469 (4.6); 7.7284 (4.3); 7.6423 (4.1); 7.4438 (1.8); 7.4236 (2.3); 7.2608 (22.6); 7.2301 (2.4); 7.2018 (1.3); 5.6612 (1.1); 5.6436 (1.6); 5.6263 (1.1); 4.5457 (9.3); 3.9683 (16.0); 1.6027 (0.9); 1.4194 (0.8); 1.3911 (6.5); 1.3745 (6.7); 1.3582 (0.7); 1.2531 (0.6); -0.0002 (31.1) I.1-65: 1H-NMR(600.3 MHz, CDCl3): δ= 8.6203 (2.3); 8.6163 (2.7); 8.5790 (2.6); 8.5751 (2.2); 8.2171 (3.2); 8.2032 (3.4); 7.7490 (3.3); 7.7351 (3.1); 7.5923 (2.4); 7.5894 (2.3); 7.4117 (1.2); 7.4086 (1.1); 7.3980 (1.4); 7.3949 (1.3); 7.2602 (37.4); 7.2008 (0.9); 7.1937 (2.6); 7.1885 (1.0); 7.1801 (2.1); 5.6582 (0.7); 5.6465 (1.0); 5.6341 (0.7); 3.9732 (1.0); 3.9667 (13.3); 3.9532 (0.3); 3.3294 (1.0); 3.3240 (1.8); 3.3208 (1.5); 3.3163 (1.8); 3.3125 (2.2); 3.3107 (2.1); 3.2872 (2.2); 3.2853 (2.1); 3.2815 (1.8); 3.2770 (1.7); 3.2742 (1.7); 3.2685 (1.1); 1.5800 (2.2); 1.3918 (5.2); 1.3806 (5.2); 1.3713 (0.5); 1.3600 (0.3); - 0.0001 (50.0) I.1-67: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.5255 (0.6); 9.5089 (0.7); 8.7108 (1.4); 8.7046 (2.1); 8.6815 (2.3); 8.6754 (1.9); 8.6699 (0.9); 8.6528 (3.7); 8.6486 (4.0); 8.4957 (1.0); 8.4916 (1.9); 8.4874 (1.0); 8.4333 (0.7); 8.2540 (1.6); 8.2498 (1.5); 8.0840 (1.9); 8.0794 (0.6); 8.0675 (0.6); 8.0628 (2.4); 7.8161 (2.1); 7.8114 (0.7); 7.7996 (0.6); 7.7949 (2.0); 5.3705 (0.6); 4.0379 (0.6); 4.0201 (0.6); 3.4101 (2.8); 3.3994 (5.9); 3.3637 (14.8); 2.5410 (16.7); 2.5242 (1.0); 2.5195 (1.3); 2.5107 (19.4); 2.5062 (42.6); 2.5016 (59.2); 2.4970 (41.1); 2.4924 (18.1); 1.9887 (2.8); 1.9088 (16.0); 1.5253 (2.3); 1.5080 (2.3); 1.2586 (0.5); 1.2348 (2.2); 1.1924 (1.2); 1.1746 (1.8); 1.1568 (0.8); 0.0080 (1.8); 0.0057 (0.7); -0.0002 (57.7); -0.0085 (1.4) BCS241005-Ausland STR 128 I.1-69: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6362 (2.8); 8.6302 (3.0); 8.5268 (2.2); 8.5207 (2.0); 8.2397 (3.3); 8.2384 (1.9); 8.2348 (1.0); 8.2232 (1.2); 8.2194 (2.4); 8.2182 (3.4); 7.7145 (0.5); 7.7104 (3.4); 7.7054 (1.0); 7.6937 (1.2); 7.6889 (3.6); 7.6847 (0.6); 7.6692 (0.9); 7.6673 (0.7); 7.2614 (18.0); 5.7782 (0.6); 5.7615 (0.6); 5.7575 (0.6); 5.7409 (0.5); 3.9713 (16.0); 1.5615 (0.5); 1.4029 (4.4); 1.3863 (4.4); 1.2552 (0.5); 0.0080 (0.6); -0.0002 (21.0); -0.0085 (0.6) I.1-70: 1 H-NMR(400.6 MHz, CDCl3): δ= 8.6442 (2.6); 8.6381 (3.2); 8.5900 (2.9); 8.5840 (2.3); 8.2289 (3.4); 8.2243 (1.3); 8.2122 (1.4); 8.2077 (3.7); 8.0562 (2.8); 8.0511 (2.7); 7.7410 (3.7); 7.7364 (1.3); 7.7243 (1.4); 7.7199 (3.4); 7.7033 (2.1); 7.6826 (3.1); 7.6006 (1.8); 7.5954 (1.7); 7.5799 (1.2); 7.5747 (1.2); 7.3095 (0.7); 7.2898 (0.7); 7.2620 (8.1); 5.6652 (0.8); 5.6482 (1.0); 5.6291 (0.8); 3.9716 (16.0); 2.0453 (0.6); 1.5886 (1.0); 1.4082 (5.7); 1.3915 (5.7); -0.0002 (10.2) I.1-71: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1227 (0.7); 9.0909 (2.8); 9.0747 (2.9); 8.6810 (4.4); 8.6754 (6.1); 8.6561 (6.2); 8.6505 (4.4); 8.1739 (6.3); 8.1700 (6.2); 8.0728 (6.5); 8.0524 (7.5); 7.9209 (0.8); 7.9003 (1.1); 7.8336 (4.0); 7.8128 (5.6); 7.7940 (7.6); 7.7737 (6.5); 7.7167 (3.3); 7.7126 (3.1); 7.6961 (2.3); 7.6915 (2.3); 5.3095 (1.7); 5.2926 (2.5); 5.2757 (1.7); 3.3260 (16.0); 2.6732 (0.5); 2.5039 (85.6); 1.4599 (9.5); 1.4428 (9.5); 1.2332 (1.1); -0.0002 (35.1) I.1-72: 1 H-NMR(600.3 MHz, CDCl3): δ= 8.6211 (2.3); 8.6171 (2.5); 8.5736 (2.4); 8.5698 (2.1); 8.2322 (3.0); 8.2184 (3.3); 7.7323 (3.3); 7.7185 (3.1); 7.6573 (2.3); 7.6551 (2.4); 7.4522 (1.1); 7.4496 (1.2); 7.4387 (1.3); 7.4361 (1.3); 7.3151 (0.9); 7.3015 (1.0); 7.2847 (36.4); 7.2481 (2.1); 7.2347 (1.8); 5.6572 (0.7); 5.6452 (1.0); 5.6334 (0.7); 4.5467 (8.7); 3.2113 (0.4); 3.2076 (0.4); 2.5839 (0.6); 2.0348 (0.3); 1.9511 (0.3); 1.3952 (5.0); 1.3841 (4.7); 1.2535 (0.8); -0.0001 (50.0); -0.0229 (0.3) I.1-73: 1H-NMR (600.3 MHz, CDCl3): δ= 8.6479 (3.2); 8.6440 (3.8); 8.6043 (3.6); 8.6005 (3.1); 8.2313 (4.2); 8.2175 (4.6); 7.7536 (4.5); 7.7399 (4.3); 7.6325 (3.4); 7.6297 (3.6); 7.4518 (1.7); 7.4488 (1.7); 7.4381 (2.0); 7.4350 (2.0); 7.4251 (1.6); 7.4119 (1.6); 7.2602 (36.0); 7.2057 (3.1); 7.1919 (2.8); 5.7400 (1.0); 5.7279 (1.4); 5.7158 (1.1); 3.3341 (1.6); 3.3280 (2.5); 3.3210 (2.4); 3.3171 (2.9); 3.3150 (2.8); 3.2896 (2.7); 3.2875 (3.0); 3.2836 (2.5); 3.2766 (2.5); 3.2704 (1.6); 1.4647 (7.2); 1.4535 (7.2); 1.2531 (1.1); -0.0001 (50.0) BCS241005-Abroad STR 129 I.1-74: 1H-NMR(600.3 MHz, d6-DMSO): δ= 8.8897 (1.3); 8.8786 (1.3); 8.7235 (0.3); 8.7195 (0.4); 8.6987 (0.4); 8.6947 (0.3); 8.6761 (2.2); 8.6722 (2.9); 8.6499 (3.0); 8.6459 (2.3); 8.0906 (3.3); 8.0767 (3.7); 7.8405 (3.6); 7.8267(3.2); 7.7377 (0.5); 7.7237(0.6); 7.6419 (1.1); 7.6390 (1.3); 7.6282 (1.1); 7.6254 (1.6); 7.6169 (2.8); 7.2367 (2.0); 7.2229 (1.9); 5.3178 (0.8); 5.3065 (1.2); 5.2951 (0.8); 3.8986 (13.0); 3.8893 (0.4); 3.6012 (0.3); 3.3190 (19.6); 2.8903 (0.6); 2.7310 (0.5); 2.5364 (0.5); 2.5187 (0.8); 2.5009 (50.0); 2.4806 (0.3); 1.7598 (0.4); 1.4558 (4.7); 1.4442 (5.1); 1.4311 (0.8); 1.2350 (0.4); 1.1733 (0.3); -0.0001 (21.6) I.1-75: 1H-NMR(600.3 MHz, d6-DMSO): δ= 8.7435 (2.3); 8.7325 (2.3); 8.7235 (0.3); 8.7195 (0.4); 8.6987 (0.4); 8.6949 (0.3); 8.6677 (4.1); 8.6637 (5.3); 8.6406(5.6); 8.6366 (4.2); 8.0872 (6.3); 8.0735 (7.0); 7.9528 (0.4); 7.8249(6.8); 7.8111 (6.1); 7.7376 (0.4); 7.7240 (0.4); 7.5112(0.6); 7.5090 (0.6); 7.4980 (0.7); 7.4956 (0.7); 7.4102 (1.2); 7.4007 (2.2); 7.3981 (2.6); 7.3874 (3.0); 7.3850 (3.1); 7.3285 (5.1); 7.3152 (3.6); 7.2834 (5.2); 7.2811 (5.0); 5.8408 (4.2); 5.8030 (17.2); 5.2849 (0.4); 5.2738 (1.6); 5.2624 (2.4); 5.2511 (1.6); 5.2396 (0.4); 3.9129 (0.4); 3.8998 (24.6); 3.8893 (0.6); 3.6011(0.6); 3.3263 (8.1); 2.8902 (2.1); 2.7309 (1.9); 2.5038 (37.5); 2.5011(50.0); 2.4984 (37.5); 1.7597(0.7); 1.4845 (0.5); 1.4424 (0.8); 1.4258 (9.0); 1.4143 (9.0); 0.9419(0.5); 0.0170 (0.4); -0.0001 (38.0) I.1-76: 1H-NMR(600.3 MHz, CDCl3): δ= 8.6152 (0.8); 8.6111 (1.0); 8.5707 (0.9); 8.5667 (0.8); 8.2146 (1.2); 8.2008 (1.2); 7.7484 (1.2); 7.7346 (1.1); 7.2975 (0.4); 7.2839 (0.6); 7.2736 (1.0); 7.2705 (0.8); 7.2600 (38.3); 7.1007 (0.8); 7.0873 (0.7); 4.4344 (0.7); 4.4266 (0.7); 4.4188 (0.7); 3.9707 (0.8); 3.9662 (4.9); 3.1697 (0.7); 3.1619 (0.7); 3.1542 (0.7); 1.5527 (2.6); 1.3842 (1.8); 1.3730 (1.8); 1.2529 (0.9); 0.0691 (1.7); 0.0178 (0.3); 0.0053 (1.9); -0.0001 (50.0); -0.0054 (1.5) I.1-77: 1H-NMR (600.3 MHz, CDCl3): δ= 8.6480 (1.5); 8.6440 (1.7); 8.5809 (1.6); 8.5768 (1.5); 8.2209 (2.2); 8.2099 (0.8); 8.2069 (2.4); 7.7660 (2.2); 7.7631 (0.8); 7.7520 (2.2); 7.5558 (1.6); 7.5522 (1.7); 7.4515 (0.9); 7.4478 (0.8); 7.4373 (0.9); 7.4336 (0.9); 7.2603 (38.2); 7.2180 (0.4); 7.2045 (0.5); 6.8547 (1.7); 6.8405 (1.6); 5.6606 (0.5); 5.6479 (0.6); 5.6362 (0.5); 4.4657 (1.4); 4.4603 (0.9); 4.4579 (1.4); 4.4555 (0.9); 4.4501 (1.5); 3.9734 (0.5); 3.9672 (10.5); 3.1495 (1.5); 3.1443 (0.9); 3.1417 (1.4); 3.1393 (0.9); 3.1340 (1.5); 2.9588 (0.6); 2.8859 (0.6); 2.0345 (0.3); 1.9947 (0.6); 1.5642 (0.6); 1.5473 (1.2); 1.5361 (1.1); 1.4544 (1.2); 1.4434 (1.2); 1.4111 (3.6); 1.3998 (3.6); 1.2529 (0.7); 1.0264 (0.3); 0.0053 (1.6); -0.0001 (50.0); -0.0056 (1.6); -0.0209 (0.3) BCS241005-Abroad STR 130 I.1-78: 1H-NMR(600.3 MHz, CDCl3): δ= 8.6756 (0.5); 8.6715 (0.6); 8.6210 (4.5); 8.6170 (5.5); 8.5919 (0.5); 8.5878 (0.6); 8.5786 (5.0); 8.5746 (4.3); 8.2175 (6.4); 8.2038 (6.6); 8.0191 (0.7); 7.7494 (6.2); 7.7355 (5.8); 7.6579 (0.8); 7.6426 (4.6); 7.6395 (4.6); 7.4860 (2.3); 7.4828 (2.3); 7.4721 (2.5); 7.4689 (2.4); 7.2674 (0.4); 7.2607 (38.2); 7.2527 (0.5); 7.1820 (1.2); 7.1689 (1.3); 6.8400 (4.4); 6.8261 (4.2); 5.7589 (20.4); 5.6715 (0.3); 5.6602 (1.3); 5.6486 (1.6); 5.6359 (1.3); 5.6247 (0.4); 4.1280 (0.3); 4.1161 (0.3); 3.9732 (3.5); 3.9677 (27.6); 3.9599 (0.8); 3.9532 (0.5); 2.9565 (5.9); 2.8845 (5.3); 2.0449 (1.4); 1.5665 (1.9); 1.3886 (9.9); 1.3775 (10.1); 1.3711 (1.7); 1.3599 (1.3); 1.2713 (0.5); 1.2594 (1.0); 1.2536 (0.6); 1.2476 (0.5); 0.0696 (0.3); 0.0053 (1.7); -0.0001 (50.0); -0.0055 (2.3) I.1-83: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6821 (1.0); 8.6760 (1.4); 8.6532 (1.7); 8.6472 (1.2); 8.0829 (1.4); 8.0615 (1.6); 7.8152 (1.6); 7.7938 (1.3); 7.5737 (0.6); 7.5695(0.8); 7.5649(0.7); 7.3821(0.5); 7.3784 (1.0); 7.3746 (0.5); 7.3007 (0.6); 7.2963 (0.9); 3.8982(6.3); 3.3180 (16.0); 2.5237 (1.1); 2.5190 (1.5); 2.5103 (22.0); 2.5057 (48.2); 2.5011 (67.6); 2.4965 (46.3); 2.4920 (20.1); 1.4586 (1.6); 1.4413 (1.6); 0.9945 (0.6); 0.9889 (0.7); 0.9734 (0.6); 0.9679 (0.6); 0.8582 (0.6); 0.7495 (0.6); 0.7454 (0.5); 0.7372 (0.5); 0.0079 (0.9); -0.0002 (32.3); -0.0027 (1.1); -0.0085 (0.9) I.1-84: 1 H-NMR(400.6 MHz, d6-DMSO): δ= 8.6710 (0.5); 8.6643(0.6); 8.6476(0.7); 8.0787 (0.6); 8.0575 (0.6); 7.8214(0.6); 3.8983 (1.3); 3.3184 (16.0); 2.5236 (1.1); 2.5189 (1.5); 2.5102(18.8); 2.5056(42.1); 2.5011(61.0); 2.4964 (38.9); 2.4919 (16.8); 1.4570 (0.8); 1.4398 (0.8); 0.0079(1.0); -0.0002 (35.0); -0.0085 (1.0) I.1-85: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7583 (1.4); 8.7417 (1.5); 8.6629 (3.6); 8.6567 (5.0); 8.6388 (5.9); 8.6327 (3.8); 8.0917 (0.5); 8.0742 (4.7); 8.0699 (1.9); 8.0577 (1.7); 8.0529 (5.4); 7.8293 (0.6); 7.8054 (5.1); 7.8006 (1.6); 7.7888 (1.6); 7.7842 (4.4); 7.4160 (1.7); 7.4121 (1.7); 7.3961 (2.5); 7.3920 (2.8); 7.3350 (4.3); 7.3150 (2.7); 7.2985 (3.7); 7.2948 (3.4); 7.2858 (0.6); 5.8412 (1.8); 5.8046 (16.0); 5.2862 (0.9); 5.2695 (1.4); 5.2525 (0.9); 3.8998 (2.1); 3.7847 (0.6); 2.6749 (0.7); 2.6703 (1.0); 2.6658 (0.7); 2.5328 (0.9); 2.5281 (1.5); 2.5240 (3.6); 2.5194 (4.8); 2.5106 (59.3); 2.5061 (126.7); 2.5015 (174.5); 2.4969 (119.8); 2.4924 (52.0); 2.4680 (0.5); 2.3331 (0.8); 2.3286 (1.0); 2.3240 (0.7); 1.4276 (5.8); 1.4104 (5.8); 0.0080 (3.0); -0.0002 (97.7); -0.0059 (0.9); -0.0068 (0.8); -0.0085 (2.7) BCS241005-Ausland STR 131 I.1-87: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7224 (3.6); 8.7059 (3.7); 8.6601 (8.6); 8.6539 (13.3); 8.6352(16.0); 8.6291 (11.1); 8.0753 (12.2); 8.0706 (3.9); 8.0588 (4.4); 8.0540 (14.7); 8.0499 (2.1); 7.8085(13.6); 7.8036(4.1); 7.7919 (3.9); 7.7872(11.7); 7.7830 (1.7); 7.6227 (9.4); 7.6173 (9.8); 7.4683 (5.6); 7.4629 (4.9); 7.4470 (5.9); 7.4415 (5.7); 6.8291 (10.9); 6.8078 (10.4); 5.2764 (2.3); 5.2595 (3.6); 5.2426 (2.4); 4.4032 (5.5); 4.3951 (4.7); 4.3917 (5.5); 4.3880 (4.6); 4.3801 (5.5); 3.9004 (0.5); 3.4359 (3.6); 3.2096 (5.9); 3.2017 (4.6); 3.1981 (5.7); 3.1945 (4.5); 3.1866 (5.3); 2.6753 (1.0); 2.6706 (1.4); 2.6660 (1.0); 2.5244 (4.5); 2.5197 (6.2); 2.5110 (79.4); 2.5064 (171.2); 2.5018 (237.6); 2.4972 (162.2); 2.4927 (70.1); 2.4711 (1.0); 2.4665 (1.1); 2.3335 (1.0); 2.3289 (1.4); 2.3243 (1.0); 1.4233 (14.2); 1.4060 (14.1); 0.0268 (0.6); 0.0080 (4.4); -0.0002(155.6); -0.0053 (1.0); -0.0061 (0.9); -0.0070 (0.8); -0.0085 (4.0); -0.0309 (0.5) I.1-88: 1H-NMR(400.6 MHz, CDCl3): δ= 8.0523 (0.8); 8.0311 (0.9); 7.6924 (0.7); 7.6739 (0.5); 7.6715 (1.0); 7.6692 (0.6); 7.5736 (0.6); 7.5712 (0.6); 7.4530 (0.5); 7.4503 (0.5); 7.4321 (0.6); 7.2601 (42.0); 6.2278 (6.9); 2.6383 (0.6); 1.5382 (16.0); 0.0080 (1.4); -0.0002 (45.9); -0.0085 (1.3) I.1-89: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6353 (2.3); 8.6293 (3.1); 8.5917 (2.4); 8.5857 (1.9); 8.2373 (2.9); 8.2325 (1.0); 8.2208 (1.0); 8.2159 (3.4); 8.2117 (0.5); 8.1466 (0.9); 8.1420 (1.6); 8.1373 (1.0); 8.0074 (1.6); 8.0060 (1.8); 8.0011 (1.7); 7.9998 (1.7); 7.9003 (0.6); 7.8978 (0.7); 7.8947 (0.6); 7.8921 (0.7); 7.8801 (0.8); 7.8775 (0.8); 7.8744 (0.8); 7.8719 (0.7); 7.7709 (3.2); 7.7659 (1.0); 7.7564 (1.8); 7.7534 (2.2); 7.7510 (2.5); 7.7495 (3.2); 7.7292 (0.6); 7.7265 (0.8); 7.7225 (0.6); 7.7098 (0.8); 7.7058 (1.0); 7.7032 (0.8); 7.5569 (1.1); 7.5373 (1.8); 7.5184 (1.1); 7.2602 (85.9); 6.5088 (1.5); 6.5043 (1.6); 6.5026 (1.7); 6.4981 (1.5); 5.7223 (0.6); 5.7055 (0.6); 5.6858 (0.6); 3.9726 (16.0); 1.5512 (4.9); 1.4390 (4.7); 1.4222 (4.7); 0.0079 (3.2); -0.0002 (123.3); -0.0085 (3.5) I.1-90: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6622 (2.4); 8.6561 (3.1); 8.6052 (2.6); 8.5991 (2.2); 8.2445 (4.9); 8.2400 (7.5); 8.2228 (1.1); 8.2180 (3.7); 8.2141 (2.4); 8.2099 (2.8); 8.2056 (1.2); 7.7383 (3.2); 7.7335 (1.1); 7.7217 (0.9); 7.7170 (3.1); 7.5186 (0.7); 7.4064 (0.6); 7.3859 (0.6); 7.2602 (133.3); 6.9966 (0.7); 5.6816 (0.6); 5.6625 (0.8); 5.6454 (0.6); 4.1310 (1.1); 4.1132 (1.1); 3.9768 (16.0); 3.1194 (1.6); 3.1080 (14.9); 2.0455 (5.1); 1.5459 (3.4); 1.4356 (4.9); 1.4189 (4.9); 1.2776 (1.5); 1.2598 (3.1); 1.2419 (1.5); 0.8638 (1.1); 0.8589 (1.8); 0.8360 (0.5); 0.8330 (0.6); 0.1457 (0.6); 0.0296 (0.6); 0.0112 (1.0); 0.0105 (0.9); 0.0080 (4.9); 0.0057 (1.6); 0.0048 (2.0); -0.0002 (183.5); -0.0065 (1.7); -0.0085 (5.1); - 0.1494 (0.5) BCS241005-Abroad STR 132 I.1-94: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6920 (2.7); 8.6859 (3.1); 8.6179 (2.6); 8.6118 (2.2); 8.5304 (1.8); 8.5263 (2.2); 8.5257 (2.2); 8.5216 (1.7); 8.4457 (0.7); 8.3909 (0.6); 8.3519 (1.8); 8.3469 (3.0); 8.3419 (1.5); 8.2686 (0.6); 8.2443 (3.2); 8.2395 (1.0); 8.2277 (1.1); 8.2229 (3.5); 8.2187 (0.5); 8.1764 (0.5); 8.1728 (0.6); 8.1690 (1.8); 8.1648 (2.3); 8.1604 (1.6); 7.7543 (0.9); 7.7500 (3.4); 7.7452 (1.1); 7.7334 (1.0); 7.7286 (3.1); 7.6212 (0.6); 7.6017 (0.6); 7.2628 (8.8); 5.6966 (0.7); 5.6794 (0.8); 5.6606 (0.6); 3.9783 (16.0); 3.1506 (0.5); 3.0210 (0.5); 1.4594 (5.0); 1.4426 (5.0); -0.0002 (14.2) I.1-95: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6748 (0.9); 8.6687 (1.4); 8.6498 (1.7); 8.6437 (1.1); 8.0698 (1.3); 8.0485 (1.5); 7.7957 (1.4); 7.7744 (1.2); 7.5954 (0.6); 7.5913 (0.9); 7.5866 (0.6); 7.3991(0.5); 7.3953 (0.9); 7.3915 (0.5); 7.3030 (0.6); 7.2985 (0.9); 4.0378 (0.5); 4.0201(0.5); 3.3191 (16.0); 2.5238 (1.0); 2.5192 (1.5); 2.5105 (21.5); 2.5059 (46.9); 2.5013 (65.4); 2.4967 (44.7); 2.4921 (19.4); 1.9887 (2.5); 1.9085 (0.5); 1.4557 (1.5); 1.4385 (1.5); 1.1923 (0.7); 1.1745 (1.5); 1.1567 (0.7); 0.9951 (0.6); 0.9894 (0.7); 0.9740 (0.6); 0.9684 (0.7); 0.7553 (0.6); 0.7522(0.5); 0.0080 (0.8); -0.0002(26.2); - 0.0026 (0.9); -0.0085 (0.6) I.1-96: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6455 (2.5); 8.6394 (3.2); 8.5934 (2.4); 8.5873 (2.0); 8.5277 (2.3); 8.5222 (2.3); 8.2316 (3.0); 8.2268 (0.9); 8.2151 (1.0); 8.2102 (3.3); 7.9967 (1.2); 7.9912 (1.1); 7.9761 (1.6); 7.9706 (1.6); 7.8779 (2.7); 7.8573 (1.9); 7.7495 (0.5); 7.7453 (3.3); 7.7404 (1.0); 7.7287 (1.0); 7.7239 (3.0); 7.2647 (9.4); 5.6848 (0.6); 5.6677 (0.7); 5.6658 (0.6); 5.6486 (0.6); 4.1486 (0.8); 4.1307 (2.4); 4.1129 (2.5); 4.0951 (0.8); 3.9730 (15.8); 3.3202 (16.0); 2.1265 (0.6); 2.0456 (12.2); 1.6332 (1.0); 1.4298 (4.7); 1.4182 (0.8); 1.4130 (4.7); 1.2773 (3.5); 1.2595 (7.1); 1.2417 (3.4); 0.8591 (0.6); - 0.0002 (11.8) I.1-97: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.0992 (0.8); 9.3866 (1.5); 9.3702 (1.5); 8.6979 (3.1); 8.6918 (4.6); 8.6712(5.0); 8.6652 (3.4); 8.5703 (2.2); 8.5654 (3.0); 8.5615 (2.4); 8.4244 (2.2); 8.4195 (4.0); 8.4144 (2.1); 8.2895 (2.4); 8.2853 (3.3); 8.2810 (2.2); 8.0632 (4.3); 8.0589 (1.6); 8.0467 (1.7); 8.0422 (5.2); 7.7847 (4.9); 7.7802 (1.7); 7.7681 (1.6); 7.7637 (4.3); 5.3558 (1.0); 5.3389 (1.5); 5.3219 (1.0); 3.3256 (16.0); 2.5259 (1.0); 2.5211 (1.5); 2.5124 (17.0); 2.5080 (35.7); 2.5034 (48.6); 2.4989 (34.3); 2.4944 (15.7); 1.5037 (5.6); 1.4864 (5.6); 1.2330 (0.9); -0.0002 (8.7) I.1-98: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6460 (2.5); 8.6399 (3.2); 8.5962 (2.3); 8.5901 (1.9); 8.2873 (2.0); 8.2816 (2.2); 8.2313 (3.0); 8.2265 (0.9); 8.2148 (0.9); 8.2099 (3.3); 8.0884 (1.1); 8.0826 (1.1); 8.0665 (1.2); 8.0607 (1.2); 7.7461 (3.0); 7.7413 (0.9); 7.7296 (0.9); 7.7247 (2.8); 7.2609 (33.0); 7.1632 (1.7); 7.1411 (1.6); 5.6851 (0.5); 5.6683 (0.6); 5.6489 (0.5); 4.0231 (12.9); 3.9727 (16.0); 2.1347 (0.6); 1.5573 (2.7); 1.4244 (0.5); 1.4186 (4.5); 1.4018 (4.5); 0.0079 (1.2); -0.0002 (41.9); -0.0027 (1.8); -0.0044 (0.6); -0.0085 (1.2) BCS241005-Abroad STR 133 I.1-99: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1000 (0.7); 9.0507 (0.9); 9.0343 (0.9); 8.6784 (1.9); 8.6723 (2.9); 8.6528 (3.2); 8.6467 (2.2); 8.3970 (2.2); 8.3913 (2.3); 8.1309 (1.0); 8.1253 (1.0); 8.1088 (1.2); 8.1032 (1.1); 8.0701 (2.6); 8.0657 (1.0); 8.0536 (1.0); 8.0490 (3.3); 7.8023(3.0); 7.7978 (1.0); 7.7857 (0.9); 7.7812 (2.6); 7.4212 (1.8); 7.3987 (1.7); 5.3203 (0.6); 5.3035 (0.9); 5.2866 (0.6); 3.9712 (10.7); 3.3217 (16.0); 2.5245 (0.9); 2.5198 (1.4); 2.5111 (19.6); 2.5066 (41.9); 2.5020 (57.9); 2.4975 (40.7); 2.4930 (18.7); 1.4643 (3.4); 1.4471 (3.4); 0.0080 (1.4); -0.0002(41.9); -0.0085 (1.4) I.1-100: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6925 (2.8); 8.6864 (3.5); 8.6278 (2.8); 8.6217 (2.4); 8.2879 (3.2); 8.2832 (1.7); 8.2792 (3.7); 8.2781 (3.7); 8.2754 (3.6); 8.2733 (3.9); 8.2666 (3.8); 8.2219 (1.9); 8.2176 (2.8); 8.2134 (1.5); 7.7815 (3.4); 7.7768 (1.1); 7.7649 (1.0); 7.7603 (3.2); 7.6088 (0.8); 7.5893 (0.8); 7.2606 (52.4); 5.7253 (0.6); 5.7066 (0.8); 5.6891 (0.6); 5.3002 (8.3); 3.1312 (1.7); 3.1126 (16.0); 1.4941 (4.6); 1.4773 (4.6); 0.0079 (1.7); -0.0002 (69.8); -0.0085 (2.1) I.1-101: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6581 (8.7); 8.6521 (11.8); 8.6138 (9.3); 8.6077 (7.4); 8.2679 (10.2); 8.2631 (3.5); 8.2514 (3.5); 8.2466 (11.9); 8.2132 (0.6); 8.1942 (3.5); 8.1896 (6.1); 8.1849 (3.8); 8.0330 (6.8); 8.0280 (6.7); 8.0268 (6.8); 7.9172 (2.3); 7.9147 (2.7); 7.9115 (2.4); 7.9091 (2.6); 7.8969 (2.7); 7.8944 (2.9); 7.8913 (2.7); 7.8888 (2.8); 7.8793 (0.5); 7.7899 (11.3); 7.7851 (3.5); 7.7734 (3.4); 7.7686 (11.2); 7.7643 (9.7); 7.7601 (9.1); 7.7451 (3.3); 7.7412 (3.7); 7.7385 (2.9); 7.5707 (5.2); 7.5510 (8.0); 7.5310 (3.1); 7.5187 (1.6); 7.2914 (0.6); 7.2602 (283.2); 7.2330 (0.6); 6.9966 (1.5); 6.5143 (5.7); 6.5097 (6.1); 6.5081 (6.3); 6.5035 (5.6); 5.8074 (0.6); 5.7909 (2.0); 5.7715 (2.3); 5.7542 (2.1); 5.7378 (0.6); 5.2999 (13.2); 3.9734 (2.4); 3.3186 (2.4); 1.5004 (15.9); 1.4837 (16.0); 1.4346 (1.2); 1.4176 (1.0); 1.3327 (0.6); 1.2843 (0.9); 1.2545 (1.4); 1.2464 (0.9); 0.1456 (1.0); 0.0691 (0.6); 0.0309 (0.9); 0.0079 (9.4); -0.0002 (372.8); -0.0085 (10.6); -0.0275 (0.6); -0.1494 (1.2) I.1-115:. 1 H-NMR(400.6 MHz, d6-DMSO): δ= 9.1924 (0.5); 9.1757 (0.5); 8.9786 (6.1); 8.6942 (1.2); 8.6881 (1.9); 8.6677 (2.2); 8.6616 (1.5); 8.0664 (1.8); 8.0617 (0.6); 8.0500 (0.6); 8.0451 (2.1); 7.7914 (2.0); 7.7866(0.6); 7.7749(0.6); 7.7701(1.7); 5.3276(0.5); 4.0378 (0.5); 4.0201(0.5); 3.3189 (16.0); 2.6701 (0.5); 2.6517 (6.1); 2.5407 (1.2); 2.5239 (1.6); 2.5192 (2.2); 2.5105 (26.9); 2.5059 (58.3); 2.5013 (81.6); 2.4967 (55.7); 2.4921 (24.0); 1.9887 (2.5); 1.9085 (1.0); 1.4819 (2.1); 1.4647 (2.0); 1.3551 (0.7); 1.1923 (0.8); 1.1745 (1.6); 1.1567 (0.8); 0.0080 (1.3); 0.0040 (0.6); -0.0002(43.9); -0.0085 (1.1) I.1-116: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6693 (0.8); 8.6631 (1.3); 8.6455 (1.5); 8.6394 (1.0); 8.0707 (1.1); 8.0494 (1.4); 7.8027 (1.2); 7.7815 (1.1); 7.5877 (0.8); 7.5644 (0.8); 3.3182 (16.0); 2.5404 (1.2); 2.5342 (0.5); 2.5298 (0.6); 2.5236 (1.6); 2.5190 (2.1); 2.5102 (26.6); 2.5057 (57.6); 2.5010 (80.3); 2.4964 (54.6); 2.4919 (23.5); 2.2608 (1.5); 2.2573 (1.5); 1.9885 (1.8); 1.4476 (1.4); 1.4303 (1.4); 1.1922 (0.5); 1.1744 (1.1); 1.1566 (0.5); 0.0080 (1.1); -0.0002 (42.1); -0.0085 (1.1) BCS241005-Ausland STR 134 I.1-117: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.9503 (0.6); 8.9308 (0.7); 8.7531 (1.6); 8.7470 (2.1); 8.7145 (2.7); 8.7084 (2.1); 8.4724 (1.6); 8.4716 (1.5); 8.4582 (1.6); 8.4574 (1.6); 8.1090 (2.2); 8.1043 (0.7); 8.0926 (0.7); 8.0878 (2.5); 7.7788 (2.3); 7.7739(0.7); 7.7622(0.7); 7.7575 (2.1); 7.4826 (1.5); 7.4767 (1.5); 7.1740 (1.2); 7.1673 (1.1); 7.1598 (1.1); 7.1531 (1.1); 5.3719 (0.5); 3.8767 (9.6); 3.3187 (16.0); 2.6701 (0.6); 2.5407 (1.4); 2.5240 (2.0); 2.5193 (2.5); 2.5105 (32.4); 2.5059 (70.5); 2.5014 (98.4); 2.4968 (67.4); 2.4922 (29.0); 2.3284 (0.6); 1.9887 (1.5); 1.4323 (2.7); 1.4155 (2.7); 1.3551 (0.8); 1.1746 (1.0); 0.0080 (1.4); -0.0002(51.5); -0.0085 (1.4) I.1-118: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.9637 (2.1); 8.9604 (2.0); 8.9216 (0.8); 8.9027 (0.8); 8.7376 (1.9); 8.7314 (2.7); 8.7068 (3.3); 8.7007 (2.4); 8.6204 (1.7); 8.6193 (1.8); 8.6169 (1.8); 8.6157 (1.6); 8.0933 (2.7); 8.0886 (0.8); 8.0768 (0.9); 8.0720 (3.2); 7.7747 (2.9); 7.7699 (0.9); 7.7582 (0.8); 7.7535 (2.6); 5.4029 (0.6); 5.3851 (0.7); 5.3672 (0.6); 3.3189 (16.0); 2.6703 (0.6); 2.5832 (7.9); 2.5409 (1.3); 2.5241 (1.7); 2.5194 (2.4); 2.5106 (33.8); 2.5061 (74.3); 2.5015 (103.9); 2.4969 (71.3); 2.4923 (31.1); 2.3286 (0.6); 1.9888 (1.9); 1.9087 (0.6); 1.4435 (3.4); 1.4266 (3.4); 1.3551 (1.0); 1.1924 (0.6); 1.1746 (1.2); 1.1568 (0.6); 0.0081 (1.5); -0.0002 (53.6); -0.0085 (1.4) I.1-119: 1 H-NMR(400.6 MHz, CDCl3): δ= 8.5370 (0.8); 8.5270 (0.8); 8.2713 (0.8); 8.2499 (0.9); 8.2090 (0.7); 8.1797 (0.6); 8.1698 (0.5); 7.7159 (0.8); 7.6945 (0.8); 7.2601 (45.7); 3.9737 (4.2); 1.7005 (1.4); 1.6829 (1.4); 1.5368 (16.0); 0.0080 (1.7); -0.0002 (59.9); -0.0085 (1.6) I.1-120: 1H-NMR(400.6 MHz, CDCl3): δ= 8.4614 (2.3); 8.4512 (2.5); 8.2811 (0.7); 8.2611 (0.8); 8.2294 (2.8); 8.1989 (3.1); 8.1888 (2.9); 8.0225 (1.3); 7.3022 (0.5); 7.2826 (0.5); 7.2617 (10.7); 5.2998 (1.3); 5.1883 (0.6); 5.1710 (0.7); 5.1692 (0.7); 5.1520 (0.6); 3.9755 (16.0); 2.1276 (1.6); 1.4328 (0.8); 1.4186 (1.2); 1.4140 (4.8); 1.3970 (4.7); 1.3334 (0.8); 1.2846 (1.2); 1.2553 (2.3); -0.0002 (14.2) I.1-121: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.3113 (1.0); 9.2951 (1.1); 8.6865 (2.4); 8.6804 (3.7); 8.6623 (4.3); 8.6563 (2.9); 8.4201 (2.4); 8.4152 (2.4); 8.0682 (3.4); 8.0636 (1.1); 8.0518 (1.2); 8.0470 (4.1); 8.0399 (0.9); 8.0348 (0.7); 8.0192 (2.2); 8.0141 (2.3); 8.0012 (3.6); 7.9809 (1.1); 7.7949 (3.8); 7.7902 (1.1); 7.7784 (1.0); 7.7737 (3.2); 5.7568 (3.2); 5.3359 (0.7); 5.3188 (1.0); 5.3022 (0.7); 3.8950 (0.6); 3.3812 (16.0); 3.3489 (5.0); 3.1679 (1.8); 2.6746 (0.9); 2.6700 (1.2); 2.6654 (0.9); 2.5405 (2.9); 2.5345 (0.7); 2.5306 (0.6); 2.5237 (3.3); 2.5191 (4.8); 2.5103 (69.4); 2.5057 (150.7); 2.5011 (209.8); 2.4965 (144.1); 2.4920 (62.6); 2.3328 (0.9); 2.3282 (1.2); 2.3235 (0.8); 1.4744 (4.0); 1.4571 (3.9); 1.0551 (0.8); 0.0080 (3.5); -0.0002 (116.8); -0.0059 (0.7); -0.0085 (3.0) BCS241005-Ausland STR 135 I.1-122: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6666 (8.5); 8.6606 (11.0); 8.6163 (8.6); 8.6102 (6.9); 8.5957 (0.6); 8.2725 (10.0); 8.2678 (3.2); 8.2560 (3.3); 8.2512 (11.3); 8.2185 (0.7); 8.1373 (3.4); 8.1325 (5.5); 8.1278 (3.8); 8.0270 (13.0); 8.0255 (12.8); 7.9930 (0.7); 7.8602 (2.2); 7.8578 (2.6); 7.8545 (2.2); 7.8521 (2.4); 7.8400 (2.7); 7.8375 (2.9); 7.8343 (2.8); 7.8319 (2.7); 7.7903 (10.7); 7.7856 (3.5); 7.7738 (6.0); 7.7691 (11.3); 7.7573 (3.1); 7.7533 (3.6); 7.7506 (3.2); 7.6734 (11.3); 7.6721 (11.1); 7.5763 (3.9); 7.5563 (7.7); 7.5369 (4.4); 7.5187 (2.3); 7.2888 (1.1); 7.2685 (1.4); 7.2602 (409.9); 7.2372 (1.2); 7.2299 (0.7); 6.9966 (2.2); 5.7980 (0.6); 5.7813 (1.8); 5.7622 (2.2); 5.7448 (1.8); 5.7285 (0.6); 5.3001 (16.0); 3.9742 (2.7); 2.7788 (12.6); 1.4955 (15.3); 1.4788 (15.3); 1.4449 (1.4); 1.4281 (1.3); 1.2554 (2.0); 1.2464 (1.4); 0.1458 (1.3); 0.0690 (1.8); 0.0284 (1.3); 0.0111 (1.3); 0.0080 (12.8); -0.0002 (440.4); -0.0059 (5.4); - 0.0085 (12.0); -0.0233 (1.0); -0.0304 (0.8); -0.1494 (1.5) I.1-123:. 1 H-NMR(400.6 MHz, CDCl3): δ= 8.6408 (2.6); 8.6347 (3.3); 8.5941 (2.9); 8.5881 (2.2); 8.2374 (3.2); 8.2329 (1.1); 8.2209 (1.2); 8.2164 (3.7); 8.0851 (1.3); 8.0806 (1.9); 8.0758 (1.2); 7.9854 (4.0); 7.8353 (0.8); 7.8319 (0.8); 7.8296 (0.8); 7.8149 (1.0); 7.8118 (0.9); 7.7653 (3.6); 7.7607 (1.2); 7.7441 (4.2); 7.7398 (1.3); 7.7232 (1.2); 7.6689 (3.6); 7.5633 (1.3); 7.5435 (2.1); 7.5237 (1.0); 7.4012 (0.7); 7.3811 (0.7); 7.2604 (59.8); 5.7143 (0.7); 5.6963 (0.8); 5.6781 (0.7); 3.9741 (16.0); 2.9217 (1.7); 2.7757 (7.8); 2.0077 (1.6); 1.5524 (6.0); 1.4368 (5.5); 1.4200 (5.5); 0.0691 (0.7); 0.0079 (2.5); -0.0002 (73.8); - 0.0084 (2.2) I.1-124: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6395 (0.8); 8.6334 (1.0); 8.5937 (0.8); 8.5876 (0.6); 8.2375 (1.0); 8.2160 (1.1); 8.0166 (1.1); 8.0151 (1.2); 7.7647 (1.0); 7.7479 (0.5); 7.7433 (1.2); 7.7007 (1.0); 7.6995 (1.0); 7.5453 (0.6); 7.2602 (51.7); 3.9741 (5.0); 2.7763 (3.7); 1.5421 (16.0); 1.4358 (1.5); 1.4191 (1.5); 0.0079 (1.5); -0.0002 (57.6); -0.0061 (0.5); -0.0085 (1.6) I.1-125: 1 H-NMR(400.6 MHz, d6-DMSO): δ= 8.8190 (0.9); 8.8017 (0.9); 8.7165 (2.3); 8.7105 (3.0); 8.6738 (3.7); 8.6677 (2.9); 8.1219 (3.2); 8.1171 (0.9); 8.1053 (1.1); 8.1005 (3.6); 7.8300 (0.6); 7.8258 (3.5); 7.8209 (1.0); 7.8092 (1.0); 7.8044 (3.0); 7.0621 (6.2); 6.7894 (6.2); 6.0953 (8.5); 5.7569 (5.5); 5.2485 (0.6); 5.2314 (1.0); 5.2142 (0.6); 3.9078 (13.4); 3.3192 (16.0); 2.5407 (0.7); 2.5239 (1.0); 2.5192 (1.4); 2.5105 (17.6); 2.5059 (38.2); 2.5013 (53.1); 2.4967 (36.2); 2.4922 (15.6); 1.9887 (1.1); 1.4195 (3.7); 1.4025 (3.7); 1.1745 (0.7); 0.0080 (1.2); -0.0002 (42.6); -0.0085 (1.1) I.1-126: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6638 (2.4); 8.6577 (2.9); 8.5972 (2.3); 8.5911 (1.9); 8.2724 (2.1); 8.2520 (2.4); 8.2382 (2.9); 8.2334 (0.9); 8.2217 (1.0); 8.2168 (3.2); 8.2048 (2.3); 8.2007 (2.3); 7.9028 (1.4); 7.8986 (1.3); 7.8824 (1.2); 7.8782 (1.2); 7.7391 (3.1); 7.7343 (0.9); 7.7226 (0.9); 7.7177 (2.8); 7.4600 (0.5); 7.4405 (0.5); 7.2628 (20.0); 5.6825 (0.6); 5.6655 (0.6); 5.6464 (0.6); 3.9772 (14.8); 3.3012 (16.0); 2.9589 (1.6); 2.8861 (1.4); 2.8847 (1.3); 2.1305 (0.6); 1.4279 (4.4); 1.4219 (0.6); 1.4112 (4.4); -0.0002 (13.4) BCS241005-Abroad STR 136 I.1-127: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6566 (6.0); 8.6505 (8.4); 8.6111 (6.8); 8.6051 (5.0); 8.2720 (7.9); 8.2506 (8.9); 8.1250 (4.0); 8.0705 (9.2); 7.8567 (1.8); 7.8364 (2.2); 7.7925 (8.3); 7.7711 (9.2); 7.7669 (3.6); 7.7448 (11.1); 7.5737 (3.2); 7.5536 (4.5); 7.5339 (2.5); 7.5187 (4.8); 7.4703 (1.4); 7.2603 (837.8); 7.2462 (1.2); 7.2297 (2.5); 6.9966 (4.5); 5.7606 (1.4); 5.7415 (1.8); 5.7248 (1.5); 1.5478 (16.0); 1.4782 (12.2); 1.4614 (11.6); 1.2559 (2.8); 0.1456 (2.9); 0.0328 (1.3); 0.0080 (24.5); -0.0002 (903.2); - 0.0085 (24.5); -0.0309 (2.4); -0.1496 (2.9) I.1-128: 1H-NMR(400.6 MHz, CDCl3): δ= 8.8117 (1.6); 8.8105 (1.7); 8.8056 (1.7); 8.8043 (1.6); 8.6565 (2.6); 8.6504 (3.1); 8.5855 (2.6); 8.5795 (2.3); 8.2381 (0.5); 8.2339 (3.2); 8.2292 (1.1); 8.2174 (1.1); 8.2127 (3.5); 8.2086 (0.6); 8.1072 (1.4); 8.1010 (1.4); 8.0865 (1.5); 8.0802 (1.5); 7.7442 (0.6); 7.7401 (3.5); 7.7354 (1.1); 7.7235 (1.1); 7.7188 (3.2); 7.7148 (0.6); 7.4297 (2.4); 7.4283 (2.4); 7.4090 (2.3); 7.4076 (2.2); 7.2633 (8.4); 5.6937 (0.7); 5.6749 (0.8); 5.6576 (0.7); 3.9739 (16.0); 2.0457 (0.6); 1.4209 (5.4); 1.4041 (5.4); -0.0002 (9.0) I.1-129: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7096 (1.0); 8.7035 (1.3); 8.6705 (1.6); 8.6644 (1.2); 8.0978 (1.3); 8.0766 (1.6); 7.7956 (1.4); 7.7743 (1.3); 7.0636 (2.7); 6.7946 (2.8); 6.0952 (3.4); 3.3197 (16.0); 2.5405 (0.7); 2.5237 (0.8); 2.5191 (1.1); 2.5103 (16.1); 2.5058 (35.0); 2.5012 (48.8); 2.4966 (33.5); 2.4920 (14.6); 1.9886 (1.8); 1.4187 (1.6); 1.4017 (1.6); 1.1922 (0.5); 1.1744 (1.1); 1.1566 (0.5); 0.0080 (0.9); -0.0002 (29.8); -0.0085 (0.8) I.1-133: 1 H-NMR(400.6 MHz, CDCl3): δ= 8.6384 (0.7); 8.6324 (0.9); 8.5926 (0.8); 8.5866 (0.7); 8.2373 (1.0); 8.2164 (1.0); 8.0892 (0.6); 8.0423 (1.3); 7.7648 (1.1); 7.7432 (2.0); 7.5443 (0.6); 7.2605 (31.8); 3.9742 (4.5); 1.5468 (16.0); 1.4355 (1.6); 1.4187 (1.6); 0.0079 (1.0); -0.0002 (30.4); -0.0085 (1.0) I.1-134: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.8376 (1.0); 8.8362(1.0); 8.6885 (0.5); 8.6824(0.8); 8.6601(0.9); 8.6540 (0.7); 8.0853 (0.7); 8.0641 (0.9); 7.9162(1.0); 7.9149 (0.9); 7.8279(0.8); 7.8067(0.7); 3.3190 (16.0); 2.5406 (0.7); 2.5238 (0.7); 2.5191 (1.0); 2.5104 (17.2); 2.5058 (37.9); 2.5012(53.2); 2.4966 (36.6); 2.4920 (16.1); 1.4869 (0.8); 1.4697 (0.8); 0.0080 (1.1); -0.0002(38.0); -0.0085 (1.1) I.1-135: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6641 (2.6); 8.6580 (3.2); 8.6045 (2.4); 8.5984 (2.0); 8.2412 (3.1); 8.2364 (1.0); 8.2247 (1.1); 8.2198 (3.4); 8.1986 (1.2); 8.1949 (2.4); 8.1912 (1.3); 7.9854 (1.2); 7.8880 (1.2); 7.7395 (3.3); 7.7347 (1.0); 7.7229 (1.0); 7.7181 (3.0); 7.5188 (0.8); 7.4482 (0.5); 7.4296 (0.6); 7.2603 (139.1); 6.9967 (0.8); 5.6946 (0.6); 5.6774 (0.7); 5.6587 (0.5); 3.9772 (15.9); 3.2139 (0.9); 3.1952 (2.9); 3.1767 (3.1); 3.1581 (0.9); 2.0455 (0.7); 1.5438 (16.0); 1.4400 (4.7); 1.4233 (4.6); 1.3473 (3.3); 1.3288 (7.3); 1.3101 (3.2); 1.2597 (0.6); 0.1458 (0.6); 0.0120 (1.0); 0.0080 (6.6); 0.0064 (2.5); 0.0048 (4.0); -0.0002 (218.7); -0.0059 (1.3); -0.0067 (1.6); -0.0085 (6.0); -0.0260 (0.5); -0.1492 (0.6) BCS241005-Abroad STR 137 I.1-136: 1H-NMR (600.3 MHz, MeOD): δ = 8.6713 (4.6); 8.6672 (5.3); 8.6074 (5.5); 8.6032 (5.0); 8.3861 (8.3); 8.1921 (6.4); 8.1783 (7.1); 8.1342 (3.6); 7.8141 (6.9); 7.8003 (6.4); 7.3032 (4.8); 7.2928 (5.1); 7.2892 (5.6); 7.2788 (5.2); 7.1670 (6.6); 7.1626 (7.0); 7.1525 (6.7); 7.1480 (7.0); 6.9832 (3.8); 6.9787 (3.7); 6.9691 (7.1); 6.9647 (6.9); 6.9551 (3.5); 6.9507 (3.4); 5.5265 (0.8); 5.5150 (2.5); 5.5034 (2.6); 5.4919 (0.8); 4.8503 (7.2); 3.3666 (0.9); 3.3332 (4.5); 3.3305 (8.9); 3.3278 (12.8); 3.3251 (9.1); 3.3224 (4.7); 2.3608 (0.3); 2.3360 (50.0); 2.3210 (0.4); 2.0058 (0.6); 1.5554 (10.7); 1.5438 (10.8) I.1-137: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7698 (0.5); 8.7588 (1.6); 8.7526 (2.4); 8.7131 (2.4); 8.7070 (1.9); 8.1742 (0.8); 8.1555 (0.9); 8.1114 (2.1); 8.1066 (0.7); 8.0949 (0.7); 8.0900 (2.5); 7.8961(0.6); 7.8918 (0.6); 7.8733(0.5); 7.7963 (2.4); 7.7914 (0.7); 7.7798(0.7); 7.7750 (2.1); 7.4453 (0.5); 7.4411 (0.5); 7.4247 (0.5); 7.4206 (0.5); 5.7576 (1.3); 5.3544 (0.6); 3.9081 (9.3); 3.3201 (16.0); 2.5415 (0.6); 2.5248 (0.6); 2.5201 (0.9); 2.5113 (12.8); 2.5068 (27.7); 2.5022 (38.6); 2.4976 (26.4); 2.4930 (11.5); 1.4415 (2.7); 1.4246 (2.7); 0.0080 (0.5); -0.0002 (19.4); -0.0085 (0.5) I.1-139: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7716 (1.5); 8.7549 (5.5); 8.7489 (6.4); 8.7125 (6.8); 8.7064(5.4); 8 / 1974 (1.0); 8.1772 (2.2); 8.1585 (2.5); 8.1382 (1.1); 8.0998 (0.8); 8.0955 (5.9); 8.0909 (1.8); 8.0791 (2.0); 8.0743 (6.8); 8.0702 (0.9); 7.9054 (1.6); 7.9010 (1.6); 7.8884 (1.4); 7.8869 (1.4); 7.8825 (1.5); 7.7751 (1.0); 7.7710 (6.5); 7.7662 (1.9); 7.7545 (1.8); 7.7498 (5.7); 7.7456 (0.8); 7.4475 (1.6); 7.4432 (1.6); 7.4269 (1.5); 7.4228 (1.5); 5.3826 (1.2); 5.3648 (1.6); 5.3470 (1.2); 4.0385 (1.2); 4.0207 (1.2); 3.3222 (16.0); 2.6715 (0.6); 2.5420 (1.6); 2.5349 (0.6); 2.5300 (0.8); 2.5253 (1.9); 2.5206 (2.4); 2.5118 (31.0); 2.5073 (67.2); 2.5027 (93.5); 2.4981 (63.9); 2.4935 (27.7); 2.3298 (0.5); 1.9895 (5.6); 1.9099 (2.3); 1.4413 (7.6); 1.4244 (7.6); 1.3556 (0.8); 1.1929 (1.6); 1.1813 (0.6); 1.1751 (3.3); 1.1573 (1.6); 0.0080 (0.9); -0.0002(31.2); -0.0086 (0.8) I.1-140: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1108 (3.2); 9.1723 (4.3); 9.1559 (4.5); 8.7658 (7.7); 8.7603 (7.7); 8.6901 (7.7); 8.6840 (11.8); 8.6655 (12.4); 8.6594 (8.3); 8.2067 (4.8); 8.2005 (4.8); 8.1859 (5.3); 8.1796 (5.2); 8.0737 (11.2); 8.0529 (13.5); 7.7978 (13.0); 7.7771 (11.3); 7.6103 (7.7); 7.5894 (7.3); 5.3568 (0.6); 5.3398 (2.7); 5.3229 (4.2); 5.3059 (2.8); 5.2891 (0.6); 3.4094 (0.6); 3.3919 (1.8); 3.3745 (1.9); 3.3570 (0.9); 3.3290 (11.5); 2.6733 (0.5); 2.5440 (1.0); 2.5132 (33.8); 2.5091 (66.7); 2.5047 (88.6); 2.5003 (64.3); 2.3317 (0.5); 1.9904 (0.8); 1.4748 (16.0); 1.4577 (16.0); 1.1088 (1.8); 1.0913 (3.6); 1.0739 (1.8); -0.0002 (15.3); -0.0084 (0.7) BCS241005-Ausland STR 138 I.1-142: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6502 (2.6); 8.6441 (3.2); 8.6030 (2.7); 8.5969 (2.1); 8.2307 (3.2); 8.2259 (1.0); 8.2142 (1.1); 8.2094 (3.4); 8.2051 (0.5); 7.8609 (5.9); 7.8566 (6.7); 7.8003 (1.8); 7.7960 (2.9); 7.7916 (1.4); 7.7398 (0.6); 7.7356 (3.4); 7.7308 (1.0); 7.7191 (1.0); 7.7143 (3.0); 7.2715 (0.6); 7.2619 (10.0); 5.6539 (0.6); 5.6370 (0.7); 5.6346 (0.7); 5.6176 (0.6); 3.9729 (16.0); 1.4103 (5.1); 1.3936 (5.1); -0.0002 (12.4) I.1-143: 1 H-NMR(400.6 MHz, d6-DMSO): δ= 9.1302 (1.1); 9.1139 (1.1); 8.6857 (2.1); 8.6796 (3.1); 8.6602 (3.4); 8.6542 (2.3); 8.0717 (3.0); 8.0507 (3.6); 8.0025 (1.2); 7.9982 (2.5); 7.9939 (2.2); 7.9777 (6.8); 7.9734 (4.7); 7.7849 (3.4); 7.7639 (3.0); 5.3081 (0.7); 5.2913 (1.0); 5.2742 (0.7); 3.3279 (16.0); 2.5263 (0.7); 2.5129 (12.7); 2.5085 (25.9); 2.5040 (34.8); 2.4995 (24.7); 2.4951 (11.5); 1.4650 (3.9); 1.4478 (3.9); 0.0079 (0.6); -0.0002 (15.1); -0.0085 (0.6) I.1-144: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6470 (2.5); 8.6409 (3.1); 8.5911 (2.5); 8.5850 (2.0); 8.2299 (3.0); 8.2251 (1.0); 8.2134 (1.0); 8.2086 (3.4); 7.9070 (2.3); 7.9019 (2.4); 7.7467 (0.5); 7.7425 (3.2); 7.7377 (1.0); 7.7260 (1.0); 7.7212 (3.0); 7.6513 (1.2); 7.6461 (1.1); 7.6305 (1.6); 7.6253 (1.6); 7.5302 (2.8); 7.5094 (2.0); 7.2619 (14.3); 5.6709 (0.6); 5.6539 (0.7); 5.6515 (0.7); 5.6345 (0.6); 3.9721 (16.0); 1.4100 (5.0); 1.3933 (5.0); -0.0002 (13.0) I.1-145: 1 H-NMR(400.6 MHz, CDCl3): δ= 8.6490 (2.6); 8.6429 (3.2); 8.5917 (2.6); 8.5856 (2.1); 8.2302 (3.1); 8.2254 (1.0); 8.2137 (1.1); 8.2089 (3.4); 8.2047 (0.5); 7.9083 (2.5); 7.9031 (2.5); 7.7482 (0.6); 7.7439 (3.3); 7.7392 (1.0); 7.7274 (1.0); 7.7227 (3.0); 7.6523 (1.2); 7.6471 (1.2); 7.6315 (1.7); 7.6263 (1.6); 7.5296 (2.9); 7.5088 (2.1); 7.3450 (0.5); 7.3256 (0.5); 7.2619 (13.4); 5.6712 (0.7); 5.6542 (0.8); 5.6520 (0.7); 5.6349 (0.6); 3.9720 (16.0); 1.4119 (5.2); 1.3951 (5.2); -0.0002 (13.0) I.1-146: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6437 (2.5); 8.6376 (3.2); 8.5897 (2.6); 8.5836 (2.1); 8.2289 (3.1); 8.2242 (1.0); 8.2124 (1.0); 8.2076 (3.4); 8.2034 (0.5); 8.0563 (2.4); 8.0512 (2.5); 7.7454 (0.5); 7.7412 (3.3); 7.7364 (1.1); 7.7246 (1.0); 7.7199 (3.1); 7.7031 (2.0); 7.6824 (3.0); 7.6007 (1.7); 7.5954 (1.6); 7.5799 (1.1); 7.5747 (1.1); 7.3105 (0.5); 7.2906 (0.5); 7.2626 (16.1); 5.6650 (0.6); 5.6481 (0.7); 5.6457 (0.7); 5.6288 (0.6); 3.9717 (16.0); 1.5987 (2.0); 1.4079 (5.1); 1.3911 (5.0); -0.0002 (9.3) I.1-147: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6332 (1.7); 8.6271 (2.1); 8.5811 (1.7); 8.5750 (1.3); 8.2276 (2.1); 8.2228 (0.7); 8.2063 (2.2); 7.8119 (2.0); 7.8072 (0.6); 7.7954 (0.7); 7.7905 (2.1); 7.7570 (2.2); 7.7522 (0.7); 7.7357 (2.0); 7.5186 (0.7); 7.3596 (2.2); 7.3381 (2.0); 7.2602 (128.8); 6.9966 (0.7); 5.3001 (0.9); 3.9706 (10.6); 1.8228 (0.6); 1.8097 (1.6); 1.8035 (1.7); 1.7912 (0.6); 1.5405 (16.0); 1.4784 (0.7); 1.4649 (1.7); 1.4587 (1.7); 1.4458 (0.5); 1.4109 (3.3); 1.3942 (3.4); 0.1459 (0.6); 0.0079 (4.9); -0.0002 (158.0); -0.0085 (4.2); -0.1494 (0.6) BCS241005-Abroad STR 139 I.1-148: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6353 (1.5); 8.6292 (1.9); 8.5913 (1.6); 8.5852 (1.2); 8.2324 (1.8); 8.2277 (0.6); 8.2159 (0.6); 8.2111 (2.0); 7.7610 (2.0); 7.7561 (0.6); 7.7444 (0.6); 7.7397 (1.8); 7.6915 (0.5); 7.6803 (0.6); 7.6755 (1.9); 7.6715 (2.0); 7.5394 (0.6); 7.5354 (0.8); 7.4601 (0.8); 7.4398 (0.9); 7.2606 (27.6); 3.9718 (9.4); 1.7833 (0.7); 1.7708 (1.5); 1.7644 (1.6); 1.7522 (0.8); 1.5506 (16.0); 1.4704 (1.5); 1.4635 (1.3); 1.4200 (3.0); 1.4033 (3.0); 0.0079 (1.0); -0.0002 (33.9); -0.0085 (0.9) I.1-149: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6439 (2.6); 8.6378 (3.2); 8.5901 (2.6); 8.5840 (2.1); 8.2333 (0.5); 8.2291 (3.2); 8.2244 (1.0); 8.2126 (1.1); 8.2078 (3.3); 8.2036 (0.5); 8.0564 (2.6); 8.0513 (2.6); 7.7450 (0.6); 7.7408 (3.5); 7.7360 (1.0); 7.7242 (1.1); 7.7195 (3.0); 7.7040 (2.1); 7.6833 (3.0); 7.6008 (1.7); 7.5955 (1.6); 7.5800 (1.2); 7.5748 (1.2); 7.3073 (0.5); 7.2875 (0.5); 7.2620 (12.4); 5.6653 (0.6); 5.6482 (0.8); 5.6460 (0.7); 5.6289 (0.6); 3.9719 (16.0); 1.5827 (5.1); 1.4078 (5.2); 1.3911 (5.1); -0.0002 (13.2) I.1-150: 1 H-NMR(400.6 MHz, CDCl3): δ= 8.9334 (2.4); 8.9286 (2.4); 8.7990 (2.1); 8.7934 (2.1); 8.6582 (2.7); 8.6522 (3.2); 8.5961 (2.7); 8.5901 (2.2); 8.2795 (1.8); 8.2744 (2.9); 8.2691 (1.7); 8.2397 (0.5); 8.2354 (3.3); 8.2308 (1.0); 8.2190 (1.1); 8.2143 (3.4); 7.7440 (0.6); 7.7399 (3.9); 7.7350 (1.1); 7.7233 (1.2); 7.7185 (3.4); 7.2692 (3.6); 5.6899 (0.7); 5.6727 (0.8); 5.6538 (0.7); 3.9753 (16.0); 2.0455 (0.6); 1.4239 (5.8); 1.4072 (5.8); -0.0002 (3.2) I.1-151:1 H-NMR(400.6 MHz, d6-DMSO): δ= 9.1981 (1.6); 9.1827 (1.6); 8.8774 (3.0); 8.8269 (2.7); 8.8229 (2.6); 8.6880 (3.2); 8.6679 (3.2); 8.3843 (2.8); 8.0723 (3.4); 8.0522 (3.8); 7.7909 (3.8); 7.7710 (3.4); 5.3374 (1.0); 5.3208 (1.4); 5.3039 (1.0); 3.3297 (16.0); 2.5039 (49.6); 1.4791 (5.2); 1.4623 (5.2); - 0.0002 (11.1) I.1-152: 1 H-NMR(400.6 MHz, CDCl3): δ= 8.6577 (2.5); 8.6516 (3.1); 8.6063 (2.7); 8.6002 (2.2); 8.2356 (3.2); 8.2309 (1.0); 8.2191 (1.1); 8.2144 (3.5); 8.2102 (0.5); 7.8582 (1.4); 7.8543 (2.6); 7.8504 (1.4); 7.7420 (0.6); 7.7377 (3.4); 7.7330 (1.1); 7.7212 (1.0); 7.7165 (3.2); 7.6103 (1.4); 7.5272 (1.3); 7.3365 (0.6); 7.3164 (0.6); 7.2621 (30.2); 5.6673 (0.7); 5.6483 (0.8); 5.6311 (0.7); 3.9752 (16.0); 1.5663 (14.7); 1.4171 (5.2); 1.4004 (5.2); 0.0079 (1.2); -0.0002 (39.8); -0.0084 (1.1) I.1-153: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6573 (2.3); 8.6512 (2.8); 8.6008 (2.4); 8.5947 (2.0); 8.2358 (2.9); 8.2312 (0.9); 8.2193 (1.0); 8.2146 (3.2); 7.7380 (3.1); 7.7333 (1.0); 7.7215 (1.0); 7.7168 (2.9); 7.4764 (1.9); 7.4711 (2.2); 7.4583 (0.7); 7.4527 (0.8); 7.4490 (0.5); 7.3458 (0.5); 7.2621 (30.2); 7.1244 (0.6); 7.1219 (0.6); 7.1028 (0.6); 5.6738 (0.6); 5.6567 (0.7); 5.6375 (0.6); 3.9756 (14.7); 1.5641 (16.0); 1.4136 (4.9); 1.3969 (4.9); 0.0080 (1.2); -0.0002 (40.0); -0.0085 (1.1) BCS241005-Abroad STR 140 I.1-154: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.9652 (0.7); 8.9486(0.7); 8.6760 (1.5); 8.6699 (2.5); 8.6535 (2.9); 8.6474 (1.9); 8.0766 (2.2); 8.0720 (0.7); 8.0602 (0.8); 8.0554 (2.6); 7.8169 (2.5); 7.8122(0.7); 7.8004(0.7); 7.7957 (2.1); 7.7582 (0.7); 7.7544 (0.5); 7.7427(0.5); 7.7390 (0.8); 7.7355 (0.6); 7.6770 (0.8); 7.6729 (1.3); 7.6688 (0.7); 7.4930 (0.7); 7.4898 (0.8); 7.4882 (0.9); 7.4850 (0.6); 7.4588 (1.0); 7.4396 (1.3); 5.7568 (1.2); 5.3214 (0.7); 3.3268 (16.0); 2.5249 (0.6); 2.5202 (0.8); 2.5115 (11.6); 2.5070 (25.4); 2.5024 (35.3); 2.4978 (24.1); 2.4932 (10.5); 1.7842 (0.7); 1.7723 (1.6); 1.7649 (2.0); 1.7535 (0.9); 1.5672(0.6); 1.5645 (0.5); 1.5541 (1.8); 1.5472 (1.8); 1.4665 (2.6); 1.4493 (2.6); 1.3557 (0.7); 0.0080 (0.6); -0.0002 (24.4); -0.0085 (0.6) I.1-155: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1896 (0.5); 9.1733 (0.6); 8.6877 (1.2); 8.6816 (2.0); 8.6634 (2.2); 8.6574 (1.5); 8.0870 (0.8); 8.0831 (1.4); 8.0792 (0.9); 8.0639 (1.8); 8.0594 (0.6); 8.0475 (0.6); 8.0428 (2.1); 7.8539 (0.8); 7.7825 (2.0); 7.7778(0.6); 7.7660(0.6); 7.7613 (1.7); 7.7437(0.7); 7.7409(0.8); 7.7382(0.7); 5.3101 (0.6); 3.3208 (16.0); 2.5245 (0.8); 2.5198 (1.1); 2.5111 (17.8); 2.5065(38.7); 2.5019 (53.8); 2.4974 (36.8); 2.4928 (16.1); 1.9890 (1.4); 1.4759 (2.1); 1.4587 (2.1); 1.1748 (0.8); 0.0080 (0.7); -0.0002(24.1); -0.0085 (0.6) I.1-156: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.1415 (2.1); 9.1251 (2.1); 8.6866 (4.7); 8.6805 (7.7); 8.6634 (8.6); 8.6574 (5.5); 8.0632 (6.8); 8.0586 (2.1); 8.0468 (2.4); 8.0421 (8.0); 8.0379 (1.1); 7.7846 (7.6); 7.7799 (2.3); 7.7681 (2.2); 7.7635(6.5); 7.7420 (1.4); 7.7386 (1.6); 7.7363 (1.6); 7.7328 (1.4); 7.7188 (1.4); 7.7154 (1.7); 7.7130 (1.5); 7.7096 (1.4); 7.6409 (2.8); 7.5972 (1.4); 7.5769 (1.4); 5.3326 (1.4); 5.3157 (2.1); 5.2988 (1.4); 3.3228 (14.4); 2.6715 (0.7); 2.5420 (0.5); 2.5348 (0.6); 2.5302 (0.8); 2.5253 (2.2); 2.5206 (2.9); 2.5118 (38.3); 2.5073 (82.0); 2.5027(113.2); 2.4981 (77.1); 2.4936 (33.3); 2.3298 (0.7); 2.0865(16.0); 1.9890 (0.6); 1.9098 (0.9); 1.4785 (8.3); 1.4612 (8.3); 1.3559 (1.7); 1.1815 (0.7); 1.1412(1.0); 0.0080 (1.5); -0.0002(52.4); -0.0086 (1.4) I.1-157: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6670 (2.5); 8.6610 (3.1); 8.6110 (2.7); 8.6049 (2.2); 8.2491 (3.8); 8.2451 (5.0); 8.2402 (1.2); 8.2283 (1.1); 8.2236 (3.5); 8.2195 (0.6); 8.0189 (1.4); 7.7528 (0.6); 7.7486 (3.4); 7.7439 (1.1); 7.7321 (1.0); 7.7274 (3.1); 7.7232 (0.5); 7.4575 (0.6); 7.4376 (0.6); 7.2614 (15.5); 5.7124 (0.7); 5.6953 (0.8); 5.6763 (0.7); 3.9778 (16.0); 1.5744 (13.2); 1.4517 (5.3); 1.4350 (5.3); 0.0080 (0.6); -0.0002 (18.5); -0.0085 (0.5) I.1-158: 1 H-NMR(400.6 MHz, CDCl3): δ= 8.7064 (8.2); 8.7003 (9.8); 8.6340 (8.4); 8.6279 (7.4); 8.2961 (16.0); 8.2922 (14.2); 8.2802 (3.6); 8.2756 (10.6); 8.0246 (4.9); 7.7976 (10.2); 7.7931 (3.3); 7.7810 (3.2); 7.7765 (9.4); 7.7349 (2.4); 7.7156 (2.4); 7.5192 (0.5); 7.2607 (94.5); 5.7605 (2.0); 5.7432 (2.6); 5.7245 (2.0); 5.3001 (2.3); 1.5186 (14.6); 1.5018 (14.5); 0.0080 (3.3); -0.0002 (112.7); -0.0085 (3.3) BCS241005-Ausland STR 141 I.1-159: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.6901 (0.7); 8.6840 (1.0); 8.6632 (1.2); 8.6571 (0.8); 8.0843 (1.0); 8.0629 (1.1); 7.8209 (1.1); 7.7995 (0.9); 7.5904 (0.7); 3.8957 (4.2); 3.3201 (16.0); 2.5195 (0.5); 2.5108 (8.5); 2.5062 (18.6); 2.5016 (26.1); 2.4970 (17.8); 2.4924 (7.8); 1.9888 (0.8); 1.8024 (0.7); 1.7948 (0.7); 1.6031 (0.7); 1.5959 (0.7); 1.4756 (1.1); 1.4584 (1.1); -0.0002 (14.9) I.1-160: 1 H-NMR(400.6 MHz, CDCl3): δ= 8.6481 (4.0); 8.6421 (5.4); 8.5983 (4.5); 8.5920 (3.9); 8.2529 (5.2); 8.2319 (5.8); 7.8298 (4.9); 7.8084 (5.7); 7.7802 (5.7); 7.7593 (5.1); 7.5187 (4.4); 7.3665 (5.9); 7.3451 (5.1); 7.2601 (783.9); 6.9965 (4.2); 5.7111 (1.7); 3.9675 (1.7); 3.6253 (3.2); 2.1111 (1.6); 1.8272 (1.7); 1.8136 (4.3); 1.8073 (4.1); 1.7952 (1.9); 1.5434 (16.0); 1.4830 (3.8); 1.4689 (5.5); 1.4628 (5.8); 1.4482 (10.3); 1.4314 (9.2); 1.2547 (2.5); 0.1459 (4.0); 0.0080 (29.8); -0.0002 (964.4); -0.0085 (27.7); - 0.1494 (3.7) I.1-161: 1H-NMR (400.6 MHz, d6-DMSO): δ= 8.6759 (0.5); 8.6591 (0.6); 8.0471 (0.6); 7.7980 (0.5); 3.3202 (16.0); 2.5192 (0.7); 2.5104 (10.2); 2.5059 (22.2); 2.5013 (30.9); 2.4967 (21.1); 2.4921 (9.2); 1.9886 (1.4); 1.4726 (0.6); 1.4554 (0.6); 1.1745 (0.8); -0.0002 (15.0) I.1-163: 1 H-NMR(400.6 MHz, d6-DMSO): δ= 8.6867 (0.6); 8.6806 (1.0); 8.6645 (1.2); 8.6584 (0.8); 8.0612 (0.9); 8.0400 (1.1); 7.7926 (1.0); 7.7714(0.9); 7.7588(0.7); 3.3214(16.0); 2.5410 (0.6); 2.5242 (0.7); 2.5195 (0.9); 2.5108 (12.8); 2.5062(27.7); 2.5016 (38.4); 2.4970 (26.1); 2.4924 (11.3); 1.8301 (0.5); 1.8218(0.7); 1.6410 (0.7); 1.6331 (0.5); 1.4859 (1.0); 1.4686(1.0); -0.0002 (14.9) I.1-164: 1H-NMR(400.6 MHz, CDCl3): δ= 9.1222 (5.4); 8.6486 (2.5); 8.6425 (3.2); 8.6062 (2.7); 8.6001 (2.0); 8.5058 (1.8); 8.5025 (1.8); 8.2462 (0.5); 8.2419 (3.0); 8.2371 (1.0); 8.2254 (1.1); 8.2206 (3.4); 8.2162 (0.6); 8.1997 (1.6); 8.1785 (1.9); 7.9494 (1.5); 7.9450 (1.4); 7.9280 (1.2); 7.9236 (1.2); 7.7750 (3.2); 7.7702 (1.0); 7.7585 (1.0); 7.7537 (2.9); 7.4622 (0.5); 7.4428 (0.5); 7.2604 (71.7); 5.7483 (0.6); 5.7312 (0.7); 5.7117 (0.6); 4.1311 (1.1); 4.1132 (1.1); 3.9765 (16.0); 2.0455 (5.3); 1.5466 (4.6); 1.4482 (5.0); 1.4315 (4.9); 1.2774 (1.5); 1.2596 (3.1); 1.2418 (1.4); 0.0079 (2.6); -0.0002 (89.9); -0.0085 (2.4) I.1-165: 1 H-NMR(400.6 MHz, d6-DMSO): δ= 8.6991 (0.5); 8.6929 (0.8); 8.6702 (0.9); 8.6642 (0.6); 8.1603 (0.7); 8.0983 (0.5); 8.0733 (0.7); 8.0522 (0.9); 7.7937 (0.8); 7.7726 (0.7); 3.8986 (3.1); 3.3203 (16.0); 2.5108 (7.5); 2.5062 (16.2); 2.5017 (22.5); 2.4971 (15.5); 2.4925 (6.8); 1.4876 (0.9); 1.4704 (0.9); -0.0002 (9.6) BCS241005-Ausland STR 142 I.1-166: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.5830 (1.0); 9.5228 (16.0); 9.0118 (2.3); 8.9955 (2.4); 8.6832 (5.4); 8.6771 (8.2); 8.6576 (9.6); 8.6515 (6.5); 8.6150 (4.7); 8.6116 (4.6); 8.1563 (0.5); 8.1130 (4.1); 8.0917 (6.1); 8.0850 (7.5); 8.0804 (2.4); 8.0685 (2.7); 8.0638 (9.1); 7.9767 (4.1); 7.9723 (3.9); 7.9553 (3.1); 7.9509 (3.1); 7.8324 (8.4); 7.8276 (2.4); 7.8159 (2.4); 7.8112 (7.3); 5.3628 (1.5); 5.3460 (2.3); 5.3291 (1.5); 4.1290 (1.9); 3.5421 (2.4); 3.5153 (2.3); 3.5087 (0.7); 3.1676 (0.8); 2.6799 (0.9); 2.6753 (2.1); 2.6707 (2.9); 2.6661 (2.1); 2.5443 (0.9); 2.5412 (3.5); 2.5355 (1.9); 2.5309 (1.8); 2.5245 (7.1); 2.5198 (10.3); 2.5111 (166.8); 2.5065 (365.9); 2.5019 (511.8); 2.4973 (350.3); 2.4928 (153.8); 2.4792 (1.8); 2.4749 (1.3); 2.4705 (0.9); 2.4613 (0.6); 2.4520 (0.8); 2.3381 (0.9); 2.3336 (2.1); 2.3290 (2.9); 2.3243 (2.0); 2.3195 (0.8); 1.4863 (10.1); 1.4690 (9.6); 1.2585 (0.7); 1.2343 (1.5); 0.9565 (1.0); 0.9482 (1.0); 0.9422 (2.6); 0.9389 (2.0); 0.9244 (1.2); 0.1456 (0.8); 0.0375 (0.6); 0.0080 (7.2); -0.0002 (287.2); -0.0085 (8.0); -0.0243 (0.5); -0.0277 (0.6); -0.0315 (0.8); -0.1493 (0.8) I.1-167:. 1 H-NMR(400.6 MHz, CDCl3): δ= 8.6499 (1.0); 8.6438 (1.2); 8.6210 (1.7); 8.5993 (1.0); 8.5932 (0.8); 8.2399 (1.2); 8.2185 (1.4); 8.1309 (1.8); 7.8117 (0.5); 7.8070 (0.8); 7.8031 (0.6); 7.7587 (1.3); 7.7374 (1.2); 7.7107 (0.5); 7.7061 (1.0); 7.7014 (0.6); 7.6578 (0.6); 7.6539 (0.9); 7.6499 (0.5); 7.2604 (55.7); 4.1310 (0.6); 4.1132 (0.6); 3.9747 (6.2); 2.5940 (6.2); 2.0455 (2.6); 1.5438 (16.0); 1.4378 (1.9); 1.4210 (1.9); 1.2775 (0.8); 1.2597 (1.6); 1.2418 (0.7); 0.0080 (2.2); -0.0002 (69.2); -0.0085 (2.1) I.1-168: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6401 (1.6); 8.6340 (2.0); 8.5948 (1.8); 8.5887 (1.4); 8.3668 (1.3); 8.2354 (2.1); 8.2308 (0.7); 8.2189 (0.8); 8.2143 (2.2); 7.8819 (2.0); 7.8719 (1.5); 7.8680 (1.4); 7.7697 (2.3); 7.7650 (0.7); 7.7531 (0.7); 7.7486 (1.9); 7.2605 (45.7); 5.7228 (0.5); 4.1311 (0.6); 4.1133 (0.6); 3.9739 (10.1); 2.8702 (9.9); 2.0455 (2.9); 1.5462 (16.0); 1.4313 (3.4); 1.4147 (3.4); 1.2775 (0.8); 1.2596 (1.7); 1.2418 (0.8); 0.0079 (1.7); -0.0002 (54.5); -0.0085 (1.6) I.1-170: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6424 (1.6); 8.6363 (2.4); 8.6126 (2.0); 8.6065 (1.4); 8.3385 (1.2); 8.2451 (2.2); 8.2405 (0.7); 8.2286 (0.8); 8.2240 (2.4); 7.9568 (0.6); 7.9387 (0.6); 7.9336 (0.6); 7.9182 (0.5); 7.8966 (1.6); 7.8854 (0.6); 7.8790 (1.4); 7.8747 (1.5); 7.8677 (0.7); 7.7975 (2.4); 7.7929 (0.8); 7.7810 (0.7); 7.7764 (2.2); 7.5773 (0.8); 7.5732 (0.7); 7.5656 (0.8); 7.5597 (1.6); 7.5536 (0.7); 7.5462 (0.6); 7.5422 (0.7); 7.2603 (40.6); 5.7564 (0.6); 3.9754 (10.8); 2.0455 (0.6); 1.5465 (16.0); 1.4671 (3.7); 1.4503 (3.7); 0.0079 (1.6); -0.0002 (48.5); -0.0085 (1.5) BCS241005-Abroad STR 143 I.1-171: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6493 (2.5); 8.6432 (3.3); 8.5987 (2.9); 8.5926 (2.4); 8.3672 (2.2); 8.3635 (2.3); 8.2374 (3.3); 8.2329 (1.2); 8.2209 (1.2); 8.2164 (3.7); 7.9438 (1.1); 7.9396 (1.0); 7.9228 (1.8); 7.9186 (1.8); 7.8667 (2.8); 7.8457 (1.6); 7.7644 (3.7); 7.7600 (1.2); 7.7479 (1.1); 7.7435 (3.3); 7.5233 (0.7); 7.5039 (0.7); 7.2609 (36.9); 5.7345 (0.7); 5.7156 (0.9); 5.6981 (0.7); 4.1311 (0.7); 4.1132 (0.7); 3.9753 (16.0); 2.0456 (3.2); 1.5543 (5.3); 1.4348 (5.7); 1.4182 (5.7); 1.2774 (1.0); 1.2596 (2.0); 1.2418 (0.9); 0.0079 (1.4); -0.0002 (43.0); -0.0084 (1.5) I.1-174: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6487 (2.5); 8.6439 (3.0); 8.5918 (3.0); 8.5862 (2.6); 8.2515 (3.8); 8.2315 (4.2); 7.9090 (2.7); 7.9049 (2.8); 7.7423 (4.1); 7.7222 (3.9); 7.6526 (1.3); 7.6492 (1.2); 7.6319 (1.7); 7.6280 (1.8); 7.5346 (2.9); 7.5134 (2.2); 7.3212 (1.1); 7.3010 (1.2); 7.2625 (21.6); 7.2609 (22.3); 5.6739 (1.0); 5.6562 (1.3); 5.6391 (1.0); 4.5541 (2.2); 4.5425 (3.0); 4.5302 (2.5); 3.8893 (2.4); 3.8766 (3.2); 3.8654 (2.4); 3.7414 (2.2); 3.7321 (3.2); 3.7190 (3.2); 3.6082 (3.1); 3.5953 (3.3); 3.5851 (2.3); 3.4064 (15.8); 3.4049 (16.0); 2.0459 (0.8); 1.5765 (2.5); 1.4082 (6.3); 1.3916 (6.3); 1.2597 (1.1); 1.2434 (0.5); 0.0015 (31.4); -0.0002 (32.4) I.1-175: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6577 (5.6); 8.6348 (5.7); 8.3754 (5.9); 8.2701 (6.2); 8.2496 (7.4); 7.9675 (2.5); 7.9478 (3.0); 7.9092 (6.6); 7.8973 (6.9); 7.8744 (4.2); 7.8106 (6.9); 7.7905 (7.0); 7.5817 (3.4); 7.5661 (5.0); 7.5492 (2.9); 7.2909 (1.6); 7.2600 (205.0); 7.2577 (186.6); 5.8333 (1.7); 5.8152 (2.6); 5.7961 (1.6); 3.4933 (4.3); 1.5225 (16.0); 1.5058 (14.9); 1.2525 (1.9); 0.1457 (1.8); 0.0289 (3.4); -0.0002 (304.3); -0.0025 (269.4); -0.1496 (1.7) I.1-176: 1 H-NMR(400.6 MHz, CDCl3): δ= 8.6578 (2.7); 8.6517 (3.2); 8.6158 (3.2); 8.6101 (2.6); 8.2539 (3.8); 8.2336 (4.1); 8.1452 (3.1); 7.8053 (1.3); 7.7806 (4.6); 7.7601 (3.8); 7.7270 (3.0); 7.7063 (2.0); 7.5897 (1.2); 7.5698 (1.4); 7.5197 (0.5); 7.2605 (94.6); 6.9981 (0.6); 5.7980 (0.9); 5.7793 (1.2); 5.7627 (1.0); 4.2388 (16.0); 3.4951 (0.6); 1.5791 (1.8); 1.4821 (6.9); 1.4654 (6.9); 1.2567 (0.7); 0.1465 (0.5); - 0.0002 (120.9); -0.1490 (0.7) I.1-178: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6458 (2.5); 8.6397 (3.1); 8.5920 (2.7); 8.5860 (2.2); 8.2301 (3.1); 8.2256 (1.1); 8.2137 (1.1); 8.2090 (3.6); 8.0676 (2.5); 8.0625 (2.6); 7.7410 (3.4); 7.7364 (1.1); 7.7245 (1.0); 7.7199 (3.2); 7.6959 (1.2); 7.6907 (1.2); 7.6751 (1.6); 7.6699 (1.5); 7.5307 (2.9); 7.5099 (2.2); 7.2984 (0.6); 7.2797 (0.6); 7.2604 (46.8); 5.6684 (0.7); 5.6497 (0.8); 5.6318 (0.7); 3.9724 (16.0); 1.5484 (5.1); 1.4094 (5.4); 1.3927 (5.4); 1.2648 (0.6); 0.8820 (0.8); 0.0080 (1.8); -0.0002 (67.7); -0.0084 (2.0) BCS241005-Abroad STR 144 I.1-179: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6456 (2.6); 8.6395 (3.1); 8.5905 (2.8); 8.5844 (2.2); 8.2298 (3.2); 8.2252 (1.0); 8.2133 (1.2); 8.2087 (3.4); 7.8961 (2.5); 7.8909 (2.6); 7.7396 (3.6); 7.7349 (1.0); 7.7231 (1.2); 7.7186 (3.1); 7.7088 (2.3); 7.6880 (2.9); 7.5580 (1.6); 7.5527 (1.5); 7.5372 (1.3); 7.5320 (1.2); 7.3154 (0.6); 7.2949 (0.6); 7.2603 (56.6); 5.6688 (0.7); 5.6520 (0.8); 5.6325 (0.7); 3.9725 (16.0); 1.5455 (12.6); 1.4074 (5.5); 1.3907 (5.5); 0.0079 (2.8); -0.0002 (82.1); -0.0085 (2.2) I.1-180: 1 H-NMR(400.6 MHz, d6-DMSO): δ= 8.6880 (0.7); 8.6620 (0.8); 8.6559 (0.6); 8.0978 (0.7); 8.0766 (0.8); 7.9246 (0.5); 7.8602 (0.8); 7.8390 (0.6); 5.7571 (1.2); 3.8900 (2.8); 3.3195 (16.0); 2.5240 (0.7); 2.5193 (0.9); 2.5105 (13.1); 2.5060 (28.2); 2.5014 (39.0); 2.4968 (26.7); 2.4923 (11.7); 1.5030 (0.8); 1.4858 (0.8); 0.0080 (0.6); -0.0002 (20.7); -0.0085 (0.6) I.1-181: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6534 (2.5); 8.6473 (3.3); 8.6123 (2.9); 8.6062 (2.2); 8.3395 (2.0); 8.3353 (2.0); 8.3118 (1.5); 8.2898 (1.7); 8.2476 (3.3); 8.2430 (1.1); 8.2310 (1.2); 8.2264 (3.6); 7.9738 (1.4); 7.9693 (1.3); 7.9517 (1.2); 7.9472 (1.2); 7.9262 (1.3); 7.9055 (1.4); 7.8762 (1.5); 7.8737 (1.5); 7.8576 (1.7); 7.8551 (1.5); 7.7911 (3.6); 7.7865 (1.2); 7.7746 (1.1); 7.7700 (3.3); 7.5087 (0.6); 7.4895 (0.7); 7.4145 (1.4); 7.3947 (1.7); 7.3754 (1.2); 7.2603 (32.5); 5.7713 (0.7); 5.7525 (0.8); 5.7350 (0.7); 3.9774 (16.0); 1.5758 (0.8); 1.4711 (5.5); 1.4543 (5.5); 0.0080 (1.5); -0.0002 (46.8); -0.0084 (1.4) I.1-182: 1H-NMR(400.6 MHz, CDCl3): δ= 9.0869 (4.2); 8.6503 (2.4); 8.6443 (3.1); 8.6064 (2.9); 8.6004 (2.3); 8.5699 (2.4); 8.5667 (2.3); 8.2418 (3.4); 8.2372 (1.3); 8.2252 (1.5); 8.2207 (3.7); 8.0499 (1.5); 8.0291 (2.6); 7.9793 (1.7); 7.9754 (1.6); 7.9583 (1.0); 7.9544 (1.0); 7.7803 (3.7); 7.7757 (1.4); 7.7637 (1.4); 7.7592 (3.4); 7.5558 (0.8); 7.5366 (0.8); 7.2624 (18.9); 5.7570 (0.8); 5.7398 (0.9); 5.7206 (0.8); 3.9758 (16.0); 2.9565 (0.6); 2.8849 (0.6); 2.0453 (0.6); 1.4514 (5.8); 1.4347 (5.8); 1.2591 (1.1); 1.2561 (1.1); 1.2439 (0.5); 0.0079 (0.8); -0.0002 (14.0); -0.0084 (0.6) I.1-183: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6606 (2.6); 8.6546 (3.2); 8.6083 (2.9); 8.6023 (2.4); 8.4616 (4.0); 8.4581 (4.2); 8.2462 (3.3); 8.2416 (1.1); 8.2297 (1.1); 8.2251 (3.7); 8.2051 (1.6); 8.2013 (2.8); 8.1975 (1.4); 8.0797 (2.2); 8.0733 (2.2); 7.7954 (2.2); 7.7912 (2.2); 7.7609 (3.6); 7.7563 (1.1); 7.7444 (1.1); 7.7398 (3.3); 7.5023 (0.7); 7.4819 (0.7); 7.2609 (53.7); 6.5656 (1.6); 6.5611 (1.8); 6.5593 (1.8); 6.5548 (1.6); 5.7189 (0.7); 5.7011 (0.8); 5.6826 (0.7); 4.1310 (1.4); 4.1132 (1.4); 3.9773 (16.0); 3.1523 (15.2); 2.1032 (0.7); 2.0455 (6.4); 1.5747 (2.6); 1.4649 (5.2); 1.4482 (5.3); 1.2843 (0.7); 1.2775 (1.9); 1.2596 (4.3); 1.2418 (1.8); 0.0079 (1.9); -0.0002 (67.6); -0.0085 (1.9) BCS241005-Abroad STR 145 I.1-185: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6810 (8.8); 8.6749 (10.7); 8.6166 (9.3); 8.6105 (7.7); 8.2636 (10.1); 8.2591 (3.4); 8.2471 (3.7); 8.2425 (11.5); 8.1095 (8.7); 8.1043 (8.7); 7.7709 (11.0); 7.7664 (3.4); 7.7544 (3.7); 7.7499 (10.2); 7.7382 (4.4); 7.7330 (4.2); 7.7174 (5.2); 7.7122 (5.0); 7.5561 (2.6); 7.5395 (11.2); 7.5188 (8.2); 7.2611 (48.3); 5.7509 (0.6); 5.7339 (2.2); 5.7151 (2.6); 5.6977 (2.2); 5.6815 (0.5); 4.1502 (0.9); 4.1323 (2.6); 4.1145 (2.7); 4.0967 (0.9); 2.1333 (10.0); 2.0472 (12.2); 1.4796 (16.0); 1.4629 (16.0); 1.4322 (1.8); 1.2780 (3.4); 1.2602 (7.2); 1.2423 (4.4); 1.2225 (0.8); 0.0079 (2.1); -0.0002 (69.0); - 0.0085 (2.0) I.1-187: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6705 (6.5); 8.6644 (9.0); 8.6326 (8.0); 8.6265 (6.2); 8.3468 (5.1); 8.2703 (9.0); 8.2494 (9.8); 8.0544 (5.0); 7.9304 (2.4); 7.9089 (3.8); 7.9049 (3.7); 7.8367 (11.4); 7.8152 (10.0); 7.8017 (9.7); 7.7808 (8.6); 7.6413 (3.8); 7.6370 (4.3); 7.6290 (2.4); 7.6199 (3.5); 7.6153 (3.7); 7.5188 (1.4); 7.2900 (1.3); 7.2604 (262.6); 6.9968 (1.5); 5.8245 (1.8); 5.8068 (2.4); 5.7884 (1.9); 3.4937 (2.8); 1.5182 (16.0); 1.5015 (15.6); 1.2563 (1.6); 0.1587 (1.2); 0.1458 (1.4); 0.0295 (1.3); 0.0080 (10.0); -0.0002 (334.4); -0.0084 (10.0); -0.1494 (1.4) I.1-188: 1 H-NMR(400.6 MHz, d6-DMSO): δ= 9.4724 (0.8); 8.6541 (0.6); 8.0614 (0.5); 3.3942 (0.5); 3.3812 (0.5); 3.3179 (16.0); 2.6744 (0.5); 2.6697 (0.7); 2.6652 (0.5); 2.5235 (1.9); 2.5188 (2.6); 2.5100 (40.1); 2.5055 (87.2); 2.5009 (121.8); 2.4963 (83.7); 2.4918 (36.7); 2.3280 (0.7); 1.4866 (0.6); 1.4694 (0.6); 1.2351 (0.6); 0.0080 (2.5); -0.0002 (91.0); -0.0085 (2.5) I.1-189: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6450 (2.4); 8.6395 (2.9); 8.5889 (3.0); 8.5830 (2.4); 8.2576 (3.7); 8.2374 (4.0); 8.0577 (2.8); 8.0531 (2.8); 7.7418 (4.0); 7.7215 (3.7); 7.7051 (2.1); 7.6844 (3.1); 7.6014 (1.7); 7.5971 (1.6); 7.5808 (1.2); 7.5763 (1.1); 7.3003 (0.9); 7.2800 (1.0); 7.2607 (16.2); 5.6656 (0.9); 5.6479 (1.2); 5.6301 (0.9); 4.5388 (2.0); 4.5293 (2.3); 4.5250 (2.2); 4.5155 (2.1); 3.7752 (2.4); 3.7637 (3.2); 3.7518 (2.2); 3.4587 (16.0); 1.5708 (8.4); 1.4323 (0.5); 1.4018 (6.0); 1.3852 (6.0); 1.2560 (2.0); 0.8822 (0.6); -0.0002 (19.2); -0.0070 (0.8) I.1-190: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6451 (2.2); 8.6390 (2.6); 8.5900 (2.4); 8.5840 (1.9); 8.2500 (2.7); 8.2455 (0.9); 8.2335 (0.9); 8.2290 (2.9); 8.0575 (2.2); 8.0524 (2.2); 7.7404 (3.0); 7.7359 (0.9); 7.7238 (0.9); 7.7194 (2.6); 7.7064 (1.8); 7.6857 (2.6); 7.6014 (1.4); 7.5962 (1.3); 7.5807 (1.0); 7.5755 (1.0); 7.2997 (0.6); 7.2795 (0.6); 7.2608 (26.9); 5.6672 (0.6); 5.6501 (0.7); 5.6310 (0.6); 4.5526 (1.4); 4.5406 (1.6); 4.5283 (1.6); 3.8879 (1.7); 3.8757 (1.8); 3.8637 (1.6); 3.7404 (1.7); 3.7321 (1.5); 3.7293 (2.1); 3.7245 (1.4); 3.7173 (2.5); 3.6068 (2.5); 3.5996 (1.4); 3.5947 (2.0); 3.5919 (1.4); 3.5837 (1.6); 3.4045 (16.0); 1.5536 (4.1); 1.4049 (4.4); 1.3881 (4.4); 0.0079 (1.0); -0.0002 (33.4); -0.0085 (0.9) BCS241005-Abroad STR 146 I.1-191: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6448 (2.5); 8.6387 (3.1); 8.5868 (2.8); 8.5808 (2.3); 8.2262 (3.2); 8.2218 (1.0); 8.2098 (1.1); 8.2052 (3.5); 8.0581 (2.6); 8.0529 (2.6); 7.7258 (3.5); 7.7212 (1.1); 7.7047 (5.2); 7.6839 (3.1); 7.6008 (1.6); 7.5956 (1.6); 7.5801 (1.1); 7.5749 (1.1); 7.2974 (0.6); 7.2780 (0.7); 7.2607 (28.4); 5.6697 (0.7); 5.6524 (0.8); 5.6334 (0.7); 5.3174 (1.0); 5.3018 (1.4); 5.2862 (1.0); 1.5622 (3.7); 1.4149 (15.0); 1.3993 (16.0); 1.3858 (5.4); 0.0079 (1.1); -0.0002 (35.5); -0.0084 (1.0) I.1-192: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6364 (2.6); 8.6304 (3.1); 8.5637 (2.7); 8.5577 (2.3); 8.2347 (3.2); 8.2301 (1.1); 8.2182 (1.1); 8.2135 (3.7); 8.2094 (0.6); 7.7549 (3.5); 7.7502 (1.1); 7.7384 (1.1); 7.7338 (3.3); 7.7296 (0.5); 7.5415 (1.3); 7.5375 (1.5); 7.5215 (1.6); 7.5176 (1.7); 7.4596 (1.4); 7.4557 (1.4); 7.4405 (1.8); 7.4365 (1.5); 7.2757 (1.8); 7.2607 (27.2); 7.2562 (3.0); 7.2365 (1.3); 7.1788 (0.5); 5.6964 (0.7); 5.6796 (0.8); 5.6768 (0.8); 5.6597 (0.7); 3.9736 (16.0); 2.0453 (1.1); 1.5475 (11.2); 1.4429 (5.8); 1.4262 (5.8); 1.2596 (0.7); 0.0079 (1.0); -0.0002 (33.4); -0.0085 (1.0) I.1-193: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6325 (2.6); 8.6264 (3.1); 8.5704 (2.7); 8.5644 (2.2); 8.2332 (0.6); 8.2290 (3.3); 8.2244 (1.2); 8.2125 (1.2); 8.2078 (3.7); 7.7482 (3.6); 7.7437 (1.3); 7.7317 (1.1); 7.7270 (3.3); 7.6324 (2.5); 7.6116 (2.8); 7.4355 (2.6); 7.4306 (2.8); 7.4133 (0.6); 7.3934 (0.6); 7.3196 (1.8); 7.3146 (1.6); 7.2987 (1.6); 7.2938 (1.5); 7.2609 (18.6); 5.6894 (0.8); 5.6700 (0.9); 5.6531 (0.7); 3.9714 (16.0); 2.0452 (0.8); 1.5531 (5.0); 1.4385 (5.8); 1.4218 (5.7); 1.2595 (0.6); 0.0079 (0.8); -0.0002 (22.9); -0.0085 (0.7) I.1-194: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6583 (7.6); 8.6522 (8.7); 8.5860 (7.9); 8.5800 (6.7); 8.2675 (9.3); 8.2465 (10.2); 7.7821 (10.0); 7.7611 (9.3); 7.5513 (4.0); 7.5473 (4.4); 7.5314 (4.5); 7.5274 (5.0); 7.5191 (0.9); 7.4964 (4.1); 7.4925 (3.8); 7.4772 (5.1); 7.4733 (4.4); 7.3325 (2.3); 7.3135 (2.5); 7.2860 (5.2); 7.2662 (11.3); 7.2608 (113.8); 7.2468 (4.1); 6.9972 (0.6); 5.7559 (0.6); 5.7399 (2.1); 5.7230 (2.5); 5.7035 (2.1); 5.6858 (0.5); 1.4888 (16.0); 1.4722 (15.9); 0.1455 (0.6); 0.0330 (0.8); 0.0079 (4.8); -0.0002 (133.5); -0.0085 (5.3); -0.1494 (0.7) I.1-195: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6756 (6.5); 8.6696 (7.6); 8.6013 (7.8); 8.5953 (6.8); 8.2581 (10.1); 8.2373 (11.3); 7.7767 (10.6); 7.7558 (10.0); 7.6904 (7.7); 7.6696 (8.7); 7.6211 (2.4); 7.6013 (2.5); 7.4466 (8.8); 7.4416 (9.4); 7.3332 (5.4); 7.3282 (4.9); 7.3123 (4.8); 7.3073 (4.5); 7.2607 (70.2); 5.7662 (0.6); 5.7495 (2.3); 5.7304 (2.9); 5.7133 (2.3); 5.6970 (0.6); 1.5062 (16.0); 1.4896 (15.9); 0.0281 (0.5); 0.0079 (3.7); -0.0002 (101.8); -0.0084 (3.4) BCS241005-Abroad STR 147 I.1-196: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.0822 (0.6); 9.0649 (0.6); 8.7318 (1.6); 8.7257 (2.0); 8.6890 (2.4); 8.6829 (1.9); 8.1291 (2.1); 8.1243 (0.7); 8.1125 (0.8); 8.1077 (2.5); 7.8287 (2.3); 7.8238(0.7); 7.8121(0.7); 7.8073 (2.1); 7.4841 (2.8); 7.4830 (3.1); 7.4799 (4.6); 7.2215 (1.3); 7.2183 (1.4); 7.2173 (1.6); 7.2142 (1.2); 5.2809(0.7); 3.9089 (9.1); 3.3198 (16.0); 2.5409 (0.6); 2.5296 (0.7); 2.5241 (1.1); 2.5193 (1.4); 2.5106 (11.8); 2.5060(24.6); 2.5014 (33.8); 2.4969 (23.5); 2.4923(10.5); 1.4512 (2.7); 1.4342 (2.7); -0.0002 (14.6) I.1-197: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7242 (1.1); 8.7181 (1.4); 8.6830 (1.8); 8.6769 (1.4); 8.1307 (1.5); 8.1141 (0.6); 8.1093 (1.8); 7.8762(1.4); 7.8716 (1.4); 7.8265 (1.7); 7.8217(0.5); 7.8099(0.5); 7.8052(1.5); 7.6208 (0.8); 7.6160(0.7); 7.6004 (0.8); 7.5956 (0.8); 7 / 1893 (1.4); 7.1689 (1.2); 5.2441 (0.5); 3.9092(6.4); 3.3193 (16.0); 2.5327 (0.6); 2.5238 (1.2); 2.5192(1.5); 2.5104 (11.8); 2.5058 (24.2); 2.5013 (33.0); 2.4967 (22.7); 2.4921(10.0); 1.4391 (1.9); 1.4220 (1.8); -0.0002 (14.0) I.1-198: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1470 (2.0); 9 / 1017 (0.9); 9.0842 (1.0); 8.7285 (2.4); 8.7224 (3.1); 8.6883 (3.6); 8.6823 (2.9); 8.1075 (3.1); 8.1029 (1.0); 8.0911 (1.1); 8.0863 (3.7); 8.0821 (0.5); 7.8023 (3.4); 7.7975 (1.0); 7.7858 (1.0); 7.7811 (3.0); 7.4879(4.8); 7.4845 (7.0); 7.2432 (1.9); 7.2392 (2.6); 7.2358 (1.7); 5.3010 (0.6); 5.2839 (1.0); 5.2667(0.7); 3.3349(16.0); 2.5252(1.0); 2.5205 (1.4); 2.5117(18.2); 2.5072 (39.4); 2.5026(54.3); 2.4981 (37.1); 2.4935 (16.0); 1.4496 (3.8); 1.4326 (3.8); 0.0080 (1.2); -0.0002 (42.9); -0.0085 (1.2) I.1-199: 1H-NMR(400.6 MHz, d6-DMSO): δ= 8.7200 (1.1); 8.7139 (1.5); 8.6820(1.8); 8.6759 (1.4); 8.1072 (1.4); 8.0908 (0.5); 8.0861 (1.7); 7.8816(1.5); 7.8769(1.5); 7.7972 (1.6); 7.7760 (1.4); 7.6223(0.8); 7.6176(0.7); 7.6019 (0.8); 7.5972(0.8); 7 / 1931 (1.4); 7.1728 (1.3); 3.3317(16.0); 2.6708 (0.6); 2.5245 (1.6); 2.5199 (2.3); 2.5111 (31.3); 2.5065 (67.4); 2.5020 (92.7); 2.4974 (63.2); 2.4929 (27.3); 2.3290 (0.5); 1.4384 (1.8); 1.4214 (1.8); 0.0080 (2.6); -0.0002(85.3); -0.0060 (0.6); -0.0085 (2.2) I.1-200: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6441 (2.5); 8.6381 (3.1); 8.5862 (2.8); 8.5801 (2.3); 8.2336 (0.5); 8.2293 (3.2); 8.2248 (1.0); 8.2129 (1.1); 8.2083 (3.5); 7.7458 (0.6); 7.7416 (3.5); 7.7371 (1.1); 7.7252 (1.0); 7.7207 (3.2); 7.6995 (0.5); 7.6940 (0.6); 7.6807 (0.6); 7.6749 (0.7); 7.6673 (0.6); 7.6540 (0.5); 7.6485 (0.6); 7.5572 (0.6); 7.3179 (0.5); 7.2984 (0.5); 7.2625 (7.1); 7.2416 (0.8); 7.2369 (0.7); 7.2205 (0.6); 7.2174 (0.8); 7.1963 (0.5); 5.6722 (0.7); 5.6552 (0.8); 5.6360 (0.7); 3.9723 (16.0); 1.6101 (1.4); 1.4041 (5.7); 1.3874 (5.7); -0.0002 (8.8) BCS241005-Abroad STR 148 I.1-201: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6503 (2.6); 8.6442 (3.1); 8.5942 (2.8); 8.5881 (2.2); 8.2358 (0.6); 8.2315 (3.2); 8.2270 (1.0); 8.2151 (1.1); 8.2105 (3.5); 8.2062 (0.5); 7.7412 (0.6); 7.7370 (3.5); 7.7323 (1.1); 7.7205 (1.1); 7.7160 (3.2); 7.3551 (0.5); 7.3490 (0.7); 7.3435 (1.7); 7.3378 (1.9); 7.3346 (1.3); 7.3275 (1.5); 7.3242 (2.0); 7.3186 (1.5); 7.2616 (10.6); 6.9782 (0.6); 6.9626 (0.7); 6.9568 (1.2); 6.9510 (0.6); 6.9355 (0.6); 5.6690 (0.7); 5.6519 (0.8); 5.6327 (0.7); 3.9737 (16.0); 1.5869 (3.1); 1.4056 (5.7); 1.3889 (5.7); -0.0002 (13.7) I.1-202: 1 H-NMR(400.6 MHz, CDCl3): δ= 8.6600 (2.6); 8.6539 (3.1); 8.5998 (2.8); 8.5938 (2.3); 8.2350 (3.3); 8.2304 (1.0); 8.2184 (1.1); 8.2139 (3.5); 7.8384 (2.7); 7.8336 (2.9); 7.7325 (3.6); 7.7278 (1.1); 7.7113 (4.4); 7.3439 (0.6); 7.3247 (0.6); 7.2605 (30.3); 5.6627 (0.7); 5.6450 (0.8); 5.6266 (0.7); 3.9747 (16.0); 2.0455 (0.6); 1.5524 (8.7); 1.4156 (5.5); 1.3989 (5.4); 0.0079 (1.3); -0.0002 (42.7); -0.0085 (1.2) I.1-203: 1H-NMR(400.6 MHz, CDCl3): δ= 8.7001 (8.8); 8.6940 (10.4); 8.6236 (9.2); 8.6174 (8.0); 8.2866 (10.0); 8.2823 (3.3); 8.2701 (3.6); 8.2656 (11.2); 8.1678 (0.6); 8.1632 (0.6); 7.8927 (9.6); 7.8878 (10.1); 7.7816 (11.0); 7.7772 (3.5); 7.7650 (3.4); 7.7606 (10.3); 7.7556 (2.5); 7.7515 (4.5); 7.7480 (5.6); 7.7437 (4.1); 7.6273 (2.6); 7.6078 (2.7); 7.2615 (53.2); 5.7305 (0.5); 5.7139 (2.1); 5.6959 (2.8); 5.6778 (2.2); 5.6609 (0.6); 2.8241 (0.8); 1.4839 (15.2); 1.4672 (16.0); 1.4322 (1.0); 1.3034 (0.7); 1.2844 (1.3); 1.2815 (1.3); 1.2635 (3.6); 1.2226 (0.6); 0.8986 (1.6); 0.8819 (5.7); 0.8641 (2.5); -0.0002 (67.5); -0.0084 (3.5); - 0.0340 (0.5) I.1-204: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1056 (2.7); 8.9760(2.8); 8.9599 (2.8); 8.6775 (4.5); 8.6720 (6.0); 8.6537 (6.0); 8.6483 (4.4); 8.0702 (6.4); 8.0499 (7.2); 7.8909 (1.4); 7.8701 (1.9); 7.8421 (1.4); 7.7965 (7.3); 7.7762 (6.3); 7.7065 (2.0); 7.5365 (1.1); 7.5155 (2.1); 7.4902 (2.0); 7.4687(0.9); 5.3127 (1.8); 5.2954 (2.6); 5.2792(1.7); 3.3258 (16.0); 2.6726 (0.6); 2.5035(85.0); 2.3307 (0.6); 1.4606 (9.6); 1.4436 (9.4); -0.0002 (24.8) I.1-205: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1090 (2.5); 9.0405 (3.9); 9.0241 (3.9); 8.6839 (6.5); 8.6780 (9.2); 8.6596 (9.3); 8.6537 (6.5); 8.0712 (9.4); 8.0507 (10.9); 7.7908 (10.7); 7.7703 (9.4); 7.5232 (6.4); 7.5074 (6.1); 7.4583 (1.4); 7.4526 (1.9); 7.4356 (2.6); 7.4299 (3.5); 7.4128 (1.4); 7.4074 (1.8); 5.3342 (0.7); 5.3180 (2.5); 5.3012 (3.7); 5.2843 (2.4); 5.2672 (0.6); 3.3922 (0.6); 3.3744 (0.8); 3.3282 (16.0); 2.6730 (0.6); 2.5080 (72.5); 2.5042 (90.1); 2.5003 (70.4); 2.3313 (0.6); 1.4690 (13.9); 1.4518 (13.6); 1.0914 (0.9); -0.0002 (31.4) I.1-206: 1 H-NMR(400.6 MHz, CDCl3): δ= 8.6553 (2.2); 8.6492 (2.8); 8.6018 (2.5); 8.5958 (2.0); 8.2319 (2.9); 8.2109 (3.3); 7.8222 (0.5); 7.8095 (10.0); 7.7300 (3.2); 7.7090 (3.0); 7.3089 (0.7); 7.2891 (0.8); 7.2604 (32.0); 5.6526 (0.7); 5.6336 (0.8); 5.6165 (0.7); 3.9742 (14.0); 1.5470 (16.0); 1.4084 (5.1); 1.3917 (5.1); 0.0078 (1.8); -0.0002 (45.7); -0.0085 (1.5) BCS241005-Ausland STR 149 I.1-207: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6549 (2.6); 8.6489 (3.2); 8.6023 (2.8); 8.5962 (2.3); 8.2317 (3.3); 8.2273 (1.2); 8.2152 (1.2); 8.2106 (3.7); 7.9671 (2.8); 7.9621 (3.0); 7.8507 (3.0); 7.8457 (2.8); 7.7308 (3.6); 7.7263 (1.3); 7.7143 (1.2); 7.7097 (3.3); 7.2956 (0.8); 7.2765 (0.8); 7.2607 (20.6); 5.6498 (0.8); 5.6310 (0.9); 5.6137 (0.7); 3.9739 (16.0); 1.5611 (4.2); 1.4097 (5.6); 1.3930 (5.6); 1.2641 (0.8); 0.8819 (1.3); 0.8642 (0.5); 0.0079 (1.1); -0.0002 (29.2); -0.0085 (1.0) I.1-208: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6372 (1.6); 8.6312 (2.0); 8.5928 (1.8); 8.5867 (1.4); 8.2297 (2.1); 8.2251 (0.7); 8.2131 (0.8); 8.2086 (2.3); 8.1424 (0.9); 8.1383 (1.6); 8.1341 (0.8); 7.8494 (0.6); 7.8468 (0.7); 7.8428 (0.5); 7.8297 (0.6); 7.8271 (0.7); 7.8231 (0.5); 7.7747 (0.6); 7.7719 (0.7); 7.7682 (0.6); 7.7551 (1.1); 7.7510 (3.0); 7.7342 (0.8); 7.7297 (2.0); 7.2612 (13.2); 7.2021 (0.8); 7.1826 (1.5); 7.1631 (0.7); 5.6592 (0.6); 3.9715 (10.2); 1.5616 (16.0); 1.4117 (3.6); 1.3950 (3.6); 0.0078 (0.6); -0.0002 (13.3) I.1-209: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6324 (2.1); 8.6263 (2.5); 8.5769 (2.2); 8.5708 (1.8); 8.2256 (2.5); 8.2210 (0.9); 8.2091 (1.0); 8.2044 (2.9); 7.8052 (2.7); 7.8006 (0.9); 7.7886 (1.0); 7.7839 (3.2); 7.7493 (2.8); 7.7447 (1.0); 7.7327 (0.9); 7.7281 (2.6); 7.5477 (3.1); 7.5430 (1.0); 7.5310 (0.9); 7.5264 (2.7); 7.3187 (0.5); 7.2989 (0.6); 7.2613 (12.7); 5.6814 (0.6); 5.6641 (0.7); 5.6451 (0.6); 3.9698 (12.7); 1.5677 (16.0); 1.4027 (4.4); 1.3860 (4.4); 0.0080 (0.5); -0.0002 (13.4) I.1-210: 1 H-NMR(400.6 MHz, CDCl3): δ= 8.6487 (2.6); 8.6427 (3.4); 8.6056 (3.1); 8.5995 (2.4); 8.2302 (3.5); 8.2260 (1.3); 8.2136 (1.4); 8.2093 (4.0); 8.1806 (1.6); 8.1769 (3.0); 8.1732 (1.8); 8.0648 (6.5); 8.0611 (6.2); 7.7371 (3.8); 7.7328 (1.4); 7.7204 (1.3); 7.7161 (3.6); 7.2631 (8.1); 7.2369 (0.8); 7.2174 (0.8); 5.6412 (0.8); 5.6236 (1.0); 5.6050 (0.8); 3.9728 (16.0); 1.5999 (1.1); 1.4088 (5.9); 1.3920 (5.8); - 0.0002 (11.7) I.1-211: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.0227 (0.6); 9.0062 (0.6); 8.6809 (1.3); 8.6748 (1.9); 8.6527 (2.2); 8.6467 (1.5); 8.2751 (1.5); 8.2700 (1.4); 8.0808 (1.8); 8.0761 (0.6); 8.0643 (0.7); 8.0595 (2.2); 7.9742 (1.5); 7.9537 (1.7); 7.8066 (2.1); 7.8018 (0.6); 7.7900 (0.6); 7.7853 (1.8); 7.5044 (0.8); 7.4992 (0.8); 7.4839 (0.8); 7.4786 (0.8); 5.2694 (0.6); 3.9012 (7.9); 3.3207 (16.0); 2.5248 (1.2); 2.5201 (1.5); 2.5113 (11.1); 2.5068 (22.8); 2.5022 (31.1); 2.4976 (21.4); 2.4931 (9.4); 1.9893 (0.5); 1.4496 (2.2); 1.4323 (2.1); 0.8576 (0.8); 0.0081 (0.6); -0.0002 (19.4); -0.0085 (0.6) I.1-212: 1 H-NMR(400.6 MHz, d6-DMSO): δ= 13.1465 (0.9); 9.1835 (3.2); 9.1682 (3.2); 8.6856 (6.3); 8.6655 (6.3); 8.0659 (7.1); 8.0460 (8.5); 8.0227 (16.0); 7.7791 (7.7); 7.7592 (6.7); 5.3117 (2.0); 5.2951 (2.8); 5.2788 (2.0); 3.3423 (10.3); 2.6722 (0.7); 2.5058 (83.1); 2.3339 (0.6); 1.4786 (10.3); 1.4618 (10.0); -0.0002 (25.0) BCS241005-Ausland STR 150 I.1-213: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1290 (3.1); 9.1847 (3.6); 9.1696 (3.5); 8.6859 (6.8); 8.6651 (6.8); 8.1539 (6.7); 8.0677 (8.1); 8.0462 (12.1); 7.7813(8.2); 7.7616(7.2); 5.3081 (2.3); 5.2929 (3.1); 5.2765 (2.1); 3.3406 (16.0); 2.6728(0.9); 2.5061 (89.5); 2.3325 (0.6); 1.4757 (11.3); 1.4593(10.6); -0.0002 (23.7) I.1-214: 1 H-NMR(400.6 MHz, d6-DMSO): δ= 13.1250 (6.2); 9.0143 (4.7); 8.9981 (4.7); 8.6791(7.8); 8.6732(10.9); 8.6541 (11.3); 8.6482 (7.7); 8.1770 (9.4); 8.0809 (11.3); 8.0603 (13.0); 7.8753(4.9); 7.8559 (5.1); 7.8092(14.6); 7.7885(13.7); 7.2470 (4.2); 7.2275 (7.7); 7.2080 (3.7); 5.3253 (0.8); 5.3090 (2.8); 5.2922 (4.3); 5.2753 (2.8); 5.2587 (0.7); 3.6178 (1.2); 3.6014 (2.8); 3.5851 (1.2); 3.3910 (1.4); 3.3735 (1.5); 3.3382 (13.4); 2.6732 (0.8); 2.5082 (106.3); 2.5043 (129.5); 2.3315 (0.8); 1.7754 (1.2); 1.7593 (3.1); 1.7512 (1.5); 1.7430 (1.2); 1.4523 (16.0); 1.4352 (15.7); 1.1085 (1.4); 1.0910 (2.6); 1.0735 (1.3); -0.0002 (62.9) I.1-215: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6510 (2.6); 8.6449 (3.1); 8.5889 (2.7); 8.5828 (2.2); 8.2418 (0.5); 8.2376 (3.2); 8.2329 (1.0); 8.2211 (1.1); 8.2163 (3.5); 8.2122 (0.6); 7.9394 (1.8); 7.9192 (2.3); 7.7606 (0.6); 7.7564 (3.5); 7.7517 (1.1); 7.7399 (1.1); 7.7352 (3.3); 7.7308 (0.7); 7.7235 (2.4); 7.7030 (2.0); 7.4291 (0.6); 7.4094 (0.6); 7.2626 (12.6); 5.7114 (0.7); 5.6944 (0.8); 5.6751 (0.7); 3.9756 (16.0); 1.6060 (0.7); 1.4257 (5.4); 1.4090 (5.4); 0.0079 (0.6); -0.0002 (18.6); -0.0085 (0.5) I.1-216: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6499 (2.6); 8.6438 (3.1); 8.5886 (2.6); 8.5825 (2.2); 8.2374 (3.1); 8.2327 (1.0); 8.2209 (1.1); 8.2161 (3.6); 8.2119 (0.6); 7.9390 (1.8); 7.9188 (2.2); 7.7603 (0.6); 7.7561 (3.4); 7.7513 (1.1); 7.7395 (1.1); 7.7348 (3.2); 7.7303 (0.7); 7.7233 (2.4); 7.7029 (1.9); 7.4275 (0.5); 7.4078 (0.6); 7.2626 (12.1); 5.7112 (0.7); 5.6941 (0.8); 5.6919 (0.8); 5.6749 (0.7); 3.9755 (16.0); 1.5913 (2.0); 1.4249 (5.3); 1.4081 (5.3); 0.8818 (0.6); -0.0002 (17.5); -0.0085 (0.5) I.1-217: 1H-NMR(400.6 MHz, d6-DMSO): δ= 13.1260 (7.3); 8.9539 (4.1); 8.9374 (4.3); 8.6714 (7.7); 8.6653 (12.7); 8.6492 (13.6); 8.6431 (8.6); 8.0768 (11.3); 8.0726 (4.2); 8.0603 (4.4); 8.0559 (14.1); 7.8184 (12.2); 7.8136 (6.1); 7.8086 (13.8); 7.8024 (6.5); 7.7972 (16.0); 7.7920 (6.1); 7.7877 (12.0); 7.6060 (14.1); 7.6015 (4.5); 7.5893 (4.1); 7.5848 (12.1); 5.3246 (0.5); 5.3076 (2.5); 5.2907 (3.9); 5.2738 (2.6); 5.2566 (0.6); 3.3393 (5.7); 2.6733 (0.6); 2.5269 (1.7); 2.5222 (2.6); 2.5133 (32.7); 2.5089 (68.8); 2.5044 (93.6); 2.4999 (66.2); 2.4955 (30.1); 2.3315 (0.6); 1.4434 (14.7); 1.4262 (14.6); 1.0909 (0.6); 0.0080 (2.5); -0.0002 (73.8); -0.0085 (2.4) BCS241005-Ausland STR 151 I.1-218: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6676 (2.5); 8.6616 (3.0); 8.5885 (2.3); 8.5824 (2.0); 8.2292 (3.1); 8.2243 (1.0); 8.2127 (1.0); 8.2078 (3.4); 8.2036 (0.5); 7.7071 (3.1); 7.7022 (1.0); 7.6905 (0.9); 7.6857 (2.9); 7.3678 (6.2); 7.2626 (6.9); 5.6326 (0.6); 5.6157 (0.6); 5.6131 (0.6); 5.5962 (0.6); 3.9738 (16.0); 2.0460 (0.8); 1.6226 (0.6); 1.4059 (4.8); 1.3892 (4.8); 1.2643 (0.5); 1.2599 (0.8); 0.8818 (1.1); - 0.0002 (10.5) I.1-219: 1H-NMR(400.6 MHz, CDCl3): δ= 8.8457 (1.5); 8.8430 (1.7); 8.8256 (1.6); 8.8230 (1.6); 8.6486 (1.3); 8.6425 (3.6); 8.6363 (4.4); 8.6303 (1.6); 8.2365 (3.1); 8.2317 (1.0); 8.2200 (1.0); 8.2151 (3.5); 8.2109 (0.5); 7.7663 (3.4); 7.7615 (1.1); 7.7498 (1.0); 7.7449 (3.1); 7.5407 (0.9); 7.5380 (1.2); 7.5219 (2.3); 7.5192 (2.2); 7.4953 (2.1); 7.4753 (2.1); 7.4565 (1.1); 7.2606 (22.0); 5.7167 (0.6); 5.6999 (0.7); 5.6962 (0.7); 5.6794 (0.6); 5.2999 (2.2); 3.9761 (16.0); 1.4943 (5.0); 1.4776 (5.0); 1.2544 (1.0); 0.0079 (0.9); -0.0002 (32.9); -0.0085 (0.9) I.1-220: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.4210 (2.0); 9.4042 (2.1); 8.7135 (4.9); 8.7074(7.8); 8.6887 (8.9); 8.6826(5.9); 8.0722(0.9); 8.0680 (6.9); 8.0634 (2.3); 8.0516 (2.3); 8.0468 (8.4); 8.0427 (1.3); 7.9924(16.0); 7.7557 (1.2); 7.7516 (7.7); 7.7469 (2.5); 7.7351 (2.2); 7.7304 (7.0); 7.7263 (1.1); 5.2889 (1.4); 5.2718 (2.3); 5.2548 (1.5); 3.3296 (0.8); 3.1716 (2.5); 2.5274 (0.7); 2.5228 (0.9); 2.5140 (14.5); 2.5094 (32.7); 2.5048 (46.2); 2.5003 (32.5); 2.4957 (14.6); 2.1843 (0.7); 1.9118 (1.2); 1.4917 (8.7); 1.4745 (8.7); 1.3568 (6.1); 1.1824 (0.9); 0.0080 (0.7); -0.0002 (25.3); -0.0085 (0.7) I.1-221: 1H-NMR(400.6 MHz, d6-DMSO): δ= 9.0953 (0.6); 9.0773 (0.7); 8.7364 (1.4); 8.7303 (2.1); 8.7047 (2.4); 8.6986 (1.8); 8.5565 (1.1); 8.5545 (1.2); 8.5359 (1.2); 8.5340 (1.2); 8.0787 (2.0); 8.0741 (0.7); 8.0623(0.7); 8.0575 (2.4); 7.8267(1.0); 7.8246 (1.2); 7.8077 (1.4); 7.8058 (1.3); 7.7887 (2.2); 7.7839 (0.7); 7.7722 (0.6); 7.7674 (2.0); 7.6344 (1.1); 7.6154 (1.2); 7.6139 (1.3); 7.5950 (1.0); 5.7577 (1.0); 5.4249 (0.6); 3.3214 (16.0); 2.5249 (0.9); 2.5203 ​​(1.2); 2.5115 (16.4); 2.5069 (36.5); 2.5023 (51.3); 2.4977 (36.0); 2.4932 (16.2); 1.4888 (2.5); 1.4719 (2.5); 0.0080 (0.6); -0.0002(21.1); -0.0085 (0.6) I.1-222: 1H-NMR (400.6 MHz, CDCl3): δ= 8.6427 (1.7); 8.6367 (4.2); 8.6294 (3.3); 8.6233 (1.3); 8.2479 (0.9); 8.2456 (1.6); 8.2420 (3.5); 8.2371 (1.0); 8.2279 (1.0); 8.2255 (2.2); 8.2205 (3.5); 8.2163 (0.5); 7.7580 (3.3); 7.7531 (1.0); 7.7415 (0.9); 7.7366 (3.0); 7.6267 (1.3); 7.6244 (1.6); 7.6234 (1.5); 7.6211 (1.3); 7.6178 (1.3); 7.6149 (1.2); 7.6016 (1.2); 7.5986 (1.1); 7.4276 (0.8); 7.4241 (0.8); 7.4114 (0.7); 7.4077 (1.4); 7.4041 (0.8); 7.3913 (0.7); 7.3878 (0.7); 7.2614 (10.3); 5.7500 (0.6); 5.7332 (0.6); 5.7297 (0.6); 5.7129 (0.6); 5.2997 (2.2); 3.9780 (16.0); 1.4878 (5.0); 1.4711 (5.0); 1.2551 (0.5); -0.0002 (15.3) BCS241005-Abroad STR 152 I.1-223: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6268 (2.1); 8.6207 (3.6); 8.6044 (2.9); 8.5983 (1.7); 8.5872 (1.0); 8.5812 (1.6); 8.5637 (0.8); 8.2234 (0.6); 8.2192 (3.2); 8.2144 (1.0); 8.2027 (1.1); 8.1978 (3.5); 8.1954 (1.9); 8.1905 (0.6); 8.1788 (0.6); 8.1739 (1.7); 7.7443 (0.5); 7.7400 (3.4); 7.7352 (1.0); 7.7235 (1.0); 7.7186 (3.2); 7.7143 (0.9); 7.6925 (0.5); 7.2632 (16.0); 5.6562 (0.6); 5.6393 (0.7); 5.6358 (0.7); 5.6190 (0.6); 5.3003 (2.8); 3.9710 (16.0); 3.9609 (5.1); 3.9533 (0.9); 3.0125 (3.6); 2.3256 (1.1); 1.4261 (6.4); 1.4197 (2.9); 1.4094 (6.1); 1.2922 (0.7); 1.2745 (0.7); 1.2103 (1.4); 1.1512 (0.6); 1.1331 (1.0); 0.0079 (0.6); -0.0002 (23.9); -0.0085 (0.7) I.1-224: 1H-NMR(400.6 MHz, CDCl3): δ= 8.6780 (2.4); 8.6719 (3.1); 8.6322 (2.6); 8.6261 (2.0); 8.2326 (3.2); 8.2278 (1.0); 8.2161 (1.0); 8.2113 (3.4); 8.2071 (0.5); 7.6962 (3.3); 7.6914 (1.0); 7.6797 (1.0); 7.6749 (3.0); 7.2605 (30.5); 5.6443 (0.7); 5.6266 (0.9); 5.6092 (0.7); 3.9771 (16.0); 1.5446 (5.4); 1.4571 (5.2); 1.4405 (5.2); 0.0079 (1.2); -0.0002 (45.3); -0.0085 (1.3) I.1-225: 1 H-NMR(400.6 MHz, CDCl3): δ= 8.6481 (2.4); 8.6420 (2.9); 8.5860 (2.4); 8.5799 (2.0); 8.2302 (2.8); 8.2254 (1.0); 8.2137 (1.0); 8.2089 (3.2); 8.2047 (0.5); 7.7302 (3.0); 7.7254 (1.0); 7.7137 (0.9); 7.7089 (2.8); 7.4563 (2.4); 7.4511 (2.5); 7.2607 (27.5); 6.6034 (2.5); 6.5981 (2.5); 5.6451 (0.6); 5.6282 (0.6); 5.6250 (0.6); 5.6082 (0.6); 4.1499 (16.0); 3.9736 (15.4); 1.6086 (0.7); 1.3957 (5.0)...

Claims

BCS241005-Abroad STR 370 Claims 1. Compounds of general formula (I) or their salts, 5 wherein M for one of the groups M -1 M-2 M-3 10, where the dashed line marks the link to the rest of formula (I), R 1 for aryl or heteroaryl, 15 wherein the aryl or heteroaryl group is optionally further substituted by 1, 2 or 3 substituents bonded to ring carbon atoms and chosen independently of one another R 4 , and where, if necessary, two adjacent substituents R 4 with the ring carbon atoms to which they are bonded, they can form a saturated, partially saturated or 20 unsaturated 5- to 7-membered ring, optionally interrupted by heteroatoms and optionally further substituted, or R 1represents a five- or six-membered heterocyclyl, which may be saturated or partially saturated, which may contain one to four heteroatoms and which bears n oxo groups, 25 wherein each heteroatom is independently chosen from a group consisting of oxygen, nitrogen and sulfur, and wherein the heterocyclyl residue is optionally substituted by one, two or three substituents, which are independently chosen from BCS241005-Ausland STR 371 a group (C1-C6)-alkyl, (C1-C6)-haloalkyl, (C1-C6)-cycloalkyl, (C1-C6)-alkoxy, (C1-C6)-alkoxy-(C1-C6)-alkyl, (C2-C6)-alkenyl, (C1-C6)-haloalkoxy, halogen, aryl, heteroaryl, (heterocyclyl)aryl, 5 R 2 for hydrogen, (C1-C8)-alkyl, (C3-C8)-cycloalkyl, (C1-C8)-cyanoalkyl, (C3-C8)-cycloalkyl- (C1-C8)-alkyl, (C2-C8)-alkenyl, (C2-C8)-haloalkenyl, (C2-C8)-alkynyl, (C2-C8)-haloalkynyl, NR 11 R 12 , S(O)R 14 , SO2R 14 , C(O)OR 13 , C(O)R 13or for aryl-(C1-C8)-alkyl, wherein the aryl group optionally carries a further 1 to 5 substituents, which can be independently substituted for halogen, cyano, nitro, trimethylsilyl, pentafluorosulfanyl, -C(=S)NH2, OR 13 , NR 11 R 12 , SR 14 ,10 S(O)R 14 , SO2R 14 , C(O)OR 13 , C(O)R 13 , (C1-C8)-alkyl, (C3-C8)-cycloalkyl, (C3-C8)-cycloalkyl- (C1-C8)-alkyl, (C2-C8)-alkenyl, (C2-C8)-haloalkenyl, (C2-C8)-alkynyl, (C2-C8)-haloalkynyl, (C3- C8)-cycanocycloalkyl, (C3-C6)-halocycloalkyl, (C1-C8)-haloalkyl, (C1-C8)-cyanoalkyl, or heteroaryl-(C1-C8)-alkyl, heterocyclyl-(C1-C8)-alkyl and where heterocyclyl carries n oxo groups, 15 R 3 for (C1-C8)-alkyl, (C3-C8)-cycloalkyl, (C2-C8)-alkenyl, R 13 O-(C1-C8)-alkyl, (C3-C8)-cycloalkyl-(C1-C8)-alkyl, R 4 for Halogen, Cyano, Thiocyanato, Isothiocyanato, Pentafluorosulfanyl, Nitro, Aryldiazo, 20 NR 11 R 12 , OR 13 , SR14 , S(O)R 14 , SO2R 14 , S(O)(=N-R 11 )R 14 , S(O)(=N-R 11 )OR 13 , OSO2-Aryl, OSO2- (C1-C8)-alkyl, OSO2-(C1-C8)-haloalkyl, OSO2-(C3-C8)-cycloalkyl, C(O)OR 13 , C(O)R 13 , C(O)NR 11 R 12 , C(S)NR 11 R 12 , -C=NOR 13 , R 13 OOC-(C1-C8)-alkyl, R 13 O-(C1-C8)-alkyl, R 14 S-(C1- C8)-alkyl, R 13 (O)C-(C1-C8)-alkyl, (C1-C8)-Alkyl, Cyano-(C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2- C8)-Alkinyl, (C1-C 10 )-Haloalkyl, (C2-C8)-Haloalkenyl, (C2-C8)-Haloalkinyl, (C3-C 10 )-Cycloalkyl,25 (C4-C 10 )-Cycloalkenyl, (C4-C 10 )-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)-haloalkyl, (C1-C8)- Haloalkoxy-(C1-C8)-haloalkyl, Aryl, Aryl-(C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-haloalkyl, (C4-C 10 )-Cycloalkenyl- (C1-C8)-alkyl, (C4-C 10)-Cycloalkenyl-(C1-C8)-haloalkyl, heterocyclyl, heterocyclyl-(C1-C8)-alkyl, aryl-(C1-C8)-alkynyl, heteroaryl-(C1-C8)-alkynyl, heterocyclyl-(C1-C8)-alkynyl, tris-[(C1-30 C8)-alkyl]silyl-(C2-C8)-alkynyl, bis-[(C1-C8)-alkyl](aryl)silyl-(C2-C8)-alkynyl, bis-aryl[(C1-C8)-alkyl]silyl-(C2-C8)-alkynyl, (C3-C8)-cycloalkyl-(C2-C8)-alkynyl, Aryl-(C2-C8)-alkenyl, heteroaryl-(C2-C8)-alkenyl, Heterocyclyl-(C2-C8)-alkenyl, (C3-C8)-cycloalkyl-(C2-C8)-alkenyl, cyano-(C3-C8)-cycloalkylaminosulfonylamino, tris-[(C1-C8)-alkyl]silyl, bis-[(C1-C8)-alkyl](aryl)silyl, bis-aryl[(C1-C8)-alkyl]silyl, wherein heterocyclyl carries n oxo groups and 35 wherein cycloalkyl may be substituted by one or more substituents selected from a group consisting of (C1-C8)-alkyl, (C1-C8)-haloalkyl, halogen, cyano, carbamoyl and BCS241005-Abroad STR 372 (C1-C8)-alkylsulfonyl and wherein aryl or heteroaryl groups may be substituted by one or two alkoxycarbonyl groups, R 5, R 6 independently for hydrogen, halogen, cyano, (C1-C8)-alkyl, (C1-C8)-haloalkyl, 5 (C3-C8)-cycloalkyl, (C3-C8)-halocycloalkyl, (C2-C8)-alkenyl, (C2-C8)-alkynyl, R 13 O-(C1-C8)-alkyl, (C3-C8)-cycloalkyl-(C1-C8)-alkyl, OR 13 , NR 11 R 12 , SR 14 , S(O)R 14 , SO2R 14 , -C=NOR 13 stand, R 7 Q represents hydrogen, halogen, (C1-C8)-alkyl, (C3-C8)-cycloalkyl, (C1-C8)-alkoxy, (C1-C8)-10-haloalkoxy, (C1-C8)-haloalkyl, Q represents hydroxy or a residue of the following formulas Q -1 Q-2 steht, 15 R 8 for hydrogen, (C1-C8)-alkyl, (C1-C8)-haloalkyl, aryl, aryl-(C1-C8)-alkyl, heteroaryl, (C2-C8)-alkynyl, (C2-C8)-alkenyl, C(O)R 13 , C(O)OR 13 , (C1-C8)-alkoxy-(C1-C8)-alkyl, R 9 for hydrogen or (C1-C8) alkyl, 20 R 10für Wasserstoff, Halogen, Cyano, NO2, (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, (C3-C8)-Cycloalkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C3-C8)-Halocycloalkyl, (C3-C8)-Halocycloalkyl-(C1-C8)- alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, Aryl, Aryl-(C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1- C8)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-alkyl, R 11 R 12 N-(C1-C8)-alkyl, R 13 O-(C1-C8)-alkyl, Cyano-(C1-C8)-alkyl, (C1-C8)-Alkylcarbonyloxy-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl-25 carbonyloxy-(C1-C8)-alkyl, Arylcarbonyloxy-(C1-C8)-alkyl, Heteroarylcarbonyloxy-(C1-C8)- alkyl, Heterocyclylcarbonyloxy-(C1-C8)-alkyl, OR 13 , NR 11 R 12 , SR 14 , S(O)R 14 , SO2R 14 , R 14 S-(C1- C8)-alkyl, R 14 (O)S-(C1-C8)-alkyl, R 14O2S-(C1-C8)-alkyl, tris-[(C1-C8)-alkyl]silyl-(C1-C8)-alkyl, bis-[(C1-C8)-alkyl](aryl)silyl(C1-C8)-alkyl, [(C1-C8)-alkyl]-bis-(aryl)silyl-(C1-C8)-alkyl, Tris-[(C1-C8)-alkyl]silyl, bis-hydroxyboryl-(C1-C8)-alkyl, bis-[(C1-C8)-alkoxy]boryl-(C1-C8)-alkyl, 30 tetramethyl-1,3,2-dioxaborolan-2-yl, Tetramethyl-1,3,2-dioxaborolan-2-yl-(C1-C8)-alkyl, nitro-(C1-C8)-alkyl, C(O)OR 13 , C(O)R 13 , C(O)NR 11 R 12 , R 13 O(O)C-(C1C8)-alkyl, R 11 R 12 N(O)C- (C1-C8)-alkyl, bis-(C1-C8)-alkoxy-(C1-C8)-alkyl, where heterocyclyl carries n oxo groups, or BCS241005-Abroad STR 373 R 8 and R 10 with the carbon atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted, 3 to 10-membered monocyclic or bicyclic ring, 5 R 11 and R 12gleich oder verschieden sind und unabhängig voneinander für Wasserstoff, (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C 10 )-Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkinyl, (C3-C 10 )-Cycloalkyl, (C3-C 10 )-Halocycloalkyl, (C4-C 10 )-Cycloalkenyl, (C4- C 10 )-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)-alkyl, (C1-C8)-Haloalkoxy-(C1-C8)-alkyl, (C1- C8)-Alkylthio-(C1-C8)-alkyl, (C1-C8)-Haloalkylthio-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-10 haloalkyl, Aryl, Aryl-(C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl- (C1-C8)-alkyl, (C4-C 10 )-Cycloalkenyl-(C1-C8)-alkyl, COR 13 , SO2R 14, heterocyclyl, (C1-C8)-alkoxycarbonyl, bis-[(C1-C8)-alkyl]aminocarbonyl-(C1-C8)-alkyl, (C1-C8)-alkyl-amino-carbonyl-(C1-C8)-alkyl, aryl-(C1-C8)-alkyl-aminocarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxycarbonyl, heteroaryl-(C1-C8)-alkoxycarbonyl, (C2-C8)-alkenyloxycarbonyl, (C2-C8)-15 alkynyloxycarbonyl, heterocyclyl-(C1-C8)-alkyl, where heterocyclyl carries n oxo groups, or R 11 and R 12 with the nitrogen atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by further heteroatoms and optionally further substituted 20 times, 3 to 10-membered monocyclic or bicyclic ring, R 13 for hydrogen, (C1-C8)-alkyl, (C2-C8)-alkenyl, (C2-C8)-alkynyl, (C1-C8)-cyanoalkyl, (C1-C 10 )- Haloalkyl, (C2-C8)-haloalkenyl, (C3-C8)-haloalkynyl, (C3-C 10 )-Cycloalkyl, (C4-C 10 )- Cycloalkenyl, (C4-C 10)-Halocycloalkenyl, (C1-C8)-Alkoxy-(C1-C8)-alkyl, (C1-C8)-Haloalkoxy- 25 (C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-haloalkyl, (C1-C8)-Alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, (C1-C8)-Alkoxy-(C1-C8)-alkoxy- (C1-C8)-alkoxy-(C1-C8)-alkoxy-(C1-C8)-alkyl, Aryl, Aryl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkoxy- (C1-C8)-alkyl, Heteroaryl, Heteroaryl-(C1-C8)-alkyl, (C3-C8)-Cycloalkyl-(C1-C8)-alkyl, (C4-C 10 )- Cycloalkenyl-(C1-C8)-alkyl, Bis-[(C1-C8)-alkyl]aminocarbonyl-(C1-C8)-alkyl, (C1-C8)-Alkyl-30 aminocarbonyl-(C1-C8)-alkyl, Aryl-(C1-C8)-alkyl-aminocarbonyl-(C1-C8)-alkyl, Bis-[(C1-C8)- alkyl]amino-(C2-C6)-alkyl, (C1-C8)-Alkyl-amino-(C2C6)-alkyl, Aryl-(C1-C8)-alkylamino-(C2-C6)- alkyl, R 14 S-(C1-C8)-alkyl, R 14 (O)S-(C1-C8)-alkyl, R 14O2S-(C1-C8)-alkyl, Hydroxycarbonyl-(C1- C8)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C8)-alkyl, Tris-[(C1-C8)-Alkyl]silyl-(C1-C8)-alkyl, Bis-[(C1-C8)-Alkyl](aryl)silyl(C1-C8)-alkyl, [(C1-C8)-Alkyl]-bis-(aryl)silyl-(C1-C8)-alkyl, (C1- 35 C8)-Alkylcarbonyloxy-(C1-C8)-alkyl, (C3-C8)-Cycloalkylcarbonyloxy-(C1-C8)-alkyl, Arylcarbonyloxy-(C1-C8)-alkyl, Heteroarylcarbonyloxy-(C1-C8)-alkyl, Heterocyclylcarbonyloxy-(C1-C8)-alkyl, Aryloxy-(C1-C8)-alkyl, Heteroaryloxy-(C1-C8)-alkyl, BCS241005-Ausland STR 374 (C1-C8)-Alkoxycarbonyl steht, wobei Heterocyclyl n Oxogruppen trägt und wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl und (C1-C8)- Alkylsulfonyl, 5 R 14 für (C1-C8)-Alkyl, (C2-C8)-Alkenyl, (C2-C8)-Alkinyl, (C1-C8)-Cyanoalkyl, (C1-C 10 )-Haloalkyl, (C2-C8)-Haloalkenyl, (C3-C8)-Haloalkinyl, (C3-C 10 )-Cycloalkyl, (C4-C10 )-Cycloalkenyl, (C4-C 10 )- Halocycloalkenyl, (C1-C8)-alkoxy-(C1-C8)-alkyl, (C1-C8)-alkoxy-(C1-C8)-haloalkyl, aryl, aryl-(C1-C8)-alkyl, heteroaryl, heteroaryl-(C1-C8)-alkyl, heterocyclyl-(C1-C8)-alkyl, (C3-C8)-10 Cycloalkyl-(C1-C8)-alkyl, (C4-C 10 )-Cycloalkenyl-(C1-C8)-alkyl, Amino, Bis-[(C1-C8)-alkyl]amino, (C1-C8)-alkyl-amino, Aryl-(C1-C8)-amino, Aryl-(C1-C6)-alkyl-amino, Aryl-[(C1-C8)-alkyl]amino, (C3-C8)-Cycloalkyl-amino, (C3-C8)-Cycloalkyl-[(C1-C8)-alkyl]amino, N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl, N-Morpholinyl, wherein the last twelve residues are bonded only to sulfonyl groups and wherein Heterocyclyl carries n oxo groups, and 15 wherein Cycloalkyl may be substituted by one or more substituents selected from a group consisting of (C1-C8)-alkyl, (C1-C8)-haloalkyl, halogen, cyano, carbamoyl and (C1-C8)-alkylsulfonyl, R 15 and R 16independently of each other stand for (C1-C8)-alkyl, (C3-C8)-cycloalkyl, aryl, heteroaryl, 20 heterocyclyl, where heterocyclyl carries n oxo groups, or R 15 and R 16 with the carbon atom to which they are bonded, form a fully saturated monocyclic carbocycle of 3 to 7 members, 25 R 17 , R 18 , R 19 and R 20 2. Compounds of general formula (I) according to claim 1, wherein 35M represents one of the groups independently of each other hydrogen, halogen, (C1-C8)-alkyl, (C1-C8)-alkoxy, (C1-C8)-haloalkoxy, (C3-C8)-cycloalkyl, (C1-C8)-haloalkyl, and 30n represents 0, 1 or 2. BCS241005-Abroad STR 375 M -1 M-2 M-3 stands, where the dashed line marks the point of connection to the rest of formula (I), 5 R 1R stands for aryl or heteroaryl, wherein the aryl or heteroaryl group may be further substituted by 1, 2 or 3 independently chosen substituents bonded to ring carbon atoms 4 , and where, if necessary, two adjacent substituents R 4 with the 10 ring carbon atoms to which they are bonded, they can form a saturated, partially saturated or unsaturated 5- to 7-membered ring, optionally interrupted by heteroatoms and optionally further substituted, or R 1stands for a five- or six-membered heterocyclyl, which may be saturated or partially saturated, which may contain one to four heteroatoms and which bears n oxo groups, wherein each heteroatom is independently chosen from a group consisting of oxygen, nitrogen, and sulfur, and wherein the heterocyclyl residue is optionally substituted by one, two, or three substituents, which are independently chosen from a group consisting of (C1-C6)-alkyl, (C1-C6)-haloalkyl, (C1-C6)-cycloalkyl, (C1-C6)-alkoxy, (C1-C6)-alkoxy-(C1-C6)-alkyl, (C2-C6)-alkenyl, (C1-C6)-haloalkoxy, halogen, aryl, heteroaryl, (heterocyclyl)aryl; R 2 for hydrogen, (C1-C7)-alkyl, (C3-C7)-cycloalkyl, (C1-C7)-cyanoalkyl, (C3-C7)-cycloalkyl- (C1-C7)-alkyl, (C2-C7)-alkenyl, (C2-C7)-haloalkenyl, (C2-C7)-alkynyl, (C2-C7)-haloalkynyl, 25 NO 11 R 12 , S(O)R 14 , SO2R 14 , C(O)OR 13 , C(O)R 13or for aryl-(C1-C7)-alkyl, wherein the aryl group optionally carries 1 to 5 further substituents, which can be independently substituted for halogen, cyano, nitro, trimethylsilyl, pentafluorosulfanyl, -C(=S)NH2, OR 13 , NR 11 R 12 , SR 14 , S(O)R 14 , SO2R 14 , C(O)OR 13 , C(O)R 13 , (C1-C7)-alkyl, (C3-C7)-cycloalkyl, (C3-C7)-cycloalkyl- (C1-C7)-alkyl, (C2-C7)-alkenyl, (C2-C7)-haloalkenyl, (C2-C7)-alkynyl, (C2-C7)-haloalkynyl, (C3-30 C7)-cycanocycloalkyl, (C3-C7)-halocycloalkyl, (C1-C7)-haloalkyl, (C1-C7)-cyanoalkyl, or heteroaryl-(C1-C7)-alkyl, heterocyclyl-(C1-C7)-alkyl and where heterocyclyl carries n oxo groups, BCS241005-Abroad STR 376 R 3 for (C1-C7)-alkyl, (C3-C7)-cycloalkyl, (C2-C7)-alkenyl, R 13 O-(C1-C7)-alkyl, (C3-C7)-cycloalkyl-(C1-C7)-alkyl, 5 R 4 for halogen, cyano, thiocyanate, isothiocyanate, pentafluorosulfanyl, nitro, aryldiazo, NR 11R 12 , OR 13 , SR 14 , S(O)R 14 , SO2R 14 , S(O)(=N-R 11 )R 14 , S(O)(=N-R 11 )OR 13 , OSO2-Aryl, OSO2- (C1-C7)-alkyl, OSO2-(C1-C7)-haloalkyl, OSO2-(C3-C7)-cycloalkyl, C(O)OR 13 , C(O)R 13 C(O)NR 11 R 12 , C(S)NR 11 R 12 , -C=NOR 13 , R 13 OOC-(C1-C7)-alkyl, R 13 O-(C1-C7)-alkyl, R 13 S-(C1- C7)-alkyl, R 13(O)C-(C1-C7)-alkyl, (C1-C7)-Alkyl, Cyano-(C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2- 10 C7)-Alkinyl, (C1-C7)-Haloalkyl, (C2-C7)-Haloalkenyl, (C2-C7)-Haloalkinyl, (C3-C7)-Cycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C7)-Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-haloalkyl, (C1-C7)- Haloalkoxy-(C1-C7)-haloalkyl, Aryl, Aryl-(C1-C7)-alkyl, Heteroaryl, Heteroaryl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-haloalkyl, (C4-C7)-Cycloalkenyl- (C1-C7)-alkyl, (C4-C7)-Cycloalkenyl-(C1-C7)-haloalkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-15 alkyl, Aryl-(C1-C7)-alkinyl, Heteroaryl-(C1-C7)-alkinyl, Heterocyclyl-(C1-C7)-alkinyl, Tris-[(C1- C7)-alkyl]silyl-(C2-C7)-alkinyl, Bis-[(C1-C7)-alkyl](aryl)silyl-(C2-C7)-alkinyl, Bis-aryl[(C1-C7)- alkyl]silyl-(C2-C7)-alkinyl, (C3-C7)-Cycloalkyl-(C2-C7)-alkinyl, Aryl-(C2-C7)-alkenyl, Heteroaryl-(C2-C7)-alkenyl, Heterocyclyl-(C2-C7)-alkenyl, (C3-C7)-Cycloalkyl-(C2-C7)-alkenyl, Cyano-(C3-C7)-Cycloalkylaminosulfonylamino, Tris-[(C1-C7)-alkyl]silyl,Bis-[(C1-C7)- 20 alkyl](aryl)silyl, bis-aryl[(C1-C7)-alkyl]silyl, wherein heterocyclyl carries n oxo groups, and wherein cycloalkyl may be substituted by one or more substituents selected from a group consisting of (C1-C8)-alkyl, (C1-C8)-haloalkyl, halogen, cyano, carbamoyl, and (C1-C8)-alkylsulfonyl, and wherein aryl or heteroaryl groups may be substituted by one or two alkoxycarbonyl groups, 25 R, 5 , R 6 independently for hydrogen, halogen, cyano, (C1-C7)-alkyl, (C1-C7)-haloalkyl, (C3-C7)-cycloalkyl, (C3-C7)-halocycloalkyl, (C2-C7)-alkenyl, (C2-C7)-alkynyl, R 13 O-(C1-C7)-alkyl, (C3-C7)-cycloalkyl-(C1-C7)-alkyl, OR 13 , NR 11 R 12 , SR 14 , S(O)R 14 , SO2R 14 , -C=NOR 13 standing, 30 R 7für Wasserstoff, Halogen, (C1-C7)-Alkyl, (C1-C7)-Alkoxy, (C1-C7)-Haloalkoxy, (C3-C7)- Cycloalkyl, (C1-C7)-Haloalkyl steht, Q für Hydroxy oder einen Rest der nachfolgenden Formeln BCS241005-Ausland STR 377 Q -1 Q-2 steht, R 8 für Wasserstoff, (C1-C7)-Alkyl, (C1-C7)-Haloalkyl, Aryl, Aryl-(C1-C7)-alkyl, Heteroaryl, (C2-C7)-Alkinyl, (C2-C7)-Alkenyl, C(O)R 13 , C(O)OR 13 , (C1-C7)-Alkoxy-(C1-C7)-alkyl steht, 5 R 9 für Wasserstoff oder (C1-C7)-Alkyl steht, R 10 für Wasserstoff, Halogen, Cyano, NO2, (C1-C7)-Alkyl, (C1-C7)-Haloalkyl, (C3-C7)-Cycloalkyl, (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, (C3-C7)-Halocycloalkyl, (C3-C7)-Halocycloalkyl-(C1-C7)-10 alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, Aryl, Aryl-(C1-C7)-alkyl, Heteroaryl, Heteroaryl-(C1- C7)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-alkyl, R 11 R 12 N-(C1-C7)-alkyl, R 13O-(C1-C7)-alkyl, Cyano-(C1-C7)-alkyl, (C1-C7)-Alkylcarbonyloxy-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl- carbonyloxy-(C1-C7)-alkyl, Arylcarbonyloxy-(C1-C7)-alkyl, Heteroarylcarbonyloxy-(C1-C7)- alkyl, Heterocyclylcarbonyloxy-(C1-C7)-alkyl, OR 13 , NR 11 R 12 , SR 14 , S(O)R 14 , SO2R 14 , R 14 S-(C1- 15 C7)-alkyl, R 14 (O)S-(C1-C7)-alkyl, R 14 O2S-(C1-C7)-alkyl, Tris-[(C1-C7)-Alkyl]silyl-(C1-C7)-alkyl, Bis-[(C1-C7)-Alkyl](aryl)silyl(C1-C7)-alkyl, [(C1-C7)-Alkyl]-bis-(aryl)silyl-(C1-C7)-alkyl, Tris- [(C1-C7)-Alkyl]silyl, Bis-hydroxyboryl-(C1-C7)-alkyl, Bis-[(C1-C7)-alkoxy]boryl-(C1-C7)-alkyl, Tetramethyl-1,3,2-Dioxaborolan-2-yl, Tetramethyl-1,3,2-Dioxaborolan-2-yl-(C1-C7)-alkyl, Nitro-(C1-C7)-alkyl, C(O)OR 13 , C(O)R 13 , C(O)NR 11 R 12 , R 13 O(O)C-(C1-C7)-alkyl, R 11 R 12N(O)C- 20 (C1-C7)-alkyl, bis-(C1-C7)-alkoxy-(C1-C7)-alkyl, and wherein heterocyclyl carries n oxo groups, or R 8 and R 10 with the carbon atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted 25, 3 to 10-membered monocyclic or bicyclic ring, R 11 and R 12gleich oder verschieden sind und unabhängig voneinander für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C7)-Cyanoalkyl, (C1-C7)-Haloalkyl, (C2-C7)-Haloalkenyl, (C3-C7)-Haloalkinyl, (C3-C7)-Cycloalkyl, (C3-C7)-Halocycloalkyl, (C4-C7)-Cycloalkenyl, (C4-30 C7)-Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-alkyl, (C1-C7)-Haloalkoxy-(C1-C7)-alkyl, (C1- C7)-Alkylthio-(C1-C7)-alkyl, (C1-C7)-Haloalkylthio-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)- haloalkyl, Aryl, Aryl-(C1-C7)-alkyl, Heteroaryl, Heteroaryl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl- (C1-C7)-alkyl, (C4-C7)-Cycloalkenyl-(C1-C7)-alkyl, COR 13 , SO2R 14 , Heterocyclyl, (C1-C7)- Alkoxycarbonyl, Bis-[(C1-C7)-alkyl]aminocarbonyl-(C1-C7)-alkyl, (C1-C7)-Alkyl-amino- BCS241005-Ausland STR 378 carbonyl-(C1-C7)-alkyl, aryl-(C1-C7)-alkyl-aminocarbonyl-(C1-C7)-alkyl, aryl-(C1-C7)-alkoxycarbonyl, heteroaryl-(C1-C7)-alkoxycarbonyl, (C2-C7)-alkenyloxycarbonyl, (C2-C7)-alkynyloxycarbonyl, heterocyclyl-(C1-C7)-alkyl and where heterocyclyl carries n oxo groups, or 5 R 11 and R 12 with the nitrogen atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted, 3 to 10-membered monocyclic or bicyclic ring, 10 R 13für Wasserstoff, (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C7)-Cyanoalkyl, (C1-C7)- Haloalkyl, (C2-C7)-Haloalkenyl, (C3-C7)-Haloalkinyl, (C3-C7)-Cycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C7)-Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-alkyl, (C1-C7)-Haloalkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-haloalkyl, (C1-C7)-Alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, (C1-C7)- Alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-alkoxy-(C1-C7)-15 alkoxy-(C1-C7)-alkoxy-(C1-C7)-alkyl, Aryl, Aryl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkoxy-(C1-C7)- alkyl, Heteroaryl, Heteroaryl-(C1-C7)-alkyl, (C3-C7)-Cycloalkyl-(C1-C7)-alkyl, (C4-C7)- Cycloalkenyl-(C1-C7)-alkyl, Bis-[(C1-C7)-alkyl]aminocarbonyl-(C1-C7)-alkyl, (C1-C7)-Alkyl- aminocarbonyl-(C1-C7)-alkyl, Aryl-(C1-C7)-alkyl-aminocarbonyl-(C1-C7)-alkyl, Bis-[(C1-C7)- alkyl]amino-(C2-C6)-alkyl, (C1-C7)-Alkyl-amino-(C2-C6)-alkyl, Aryl-(C1-C7)-alkyl-amino-(C2-20 C6)-alkyl, R 14 S-(C1-C7)-alkyl, R 14 (O)S-(C1-C7)-alkyl, R14 O2S-(C1-C7)-alkyl, Hydroxycarbonyl- (C1-C7)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C7)-alkyl, Tris-[(C1-C7)-Alkyl]silyl-(C1-C7)-alkyl, Bis-[(C1-C7)-Alkyl](aryl)silyl(C1-C7)-alkyl, [(C1-C7)-Alkyl]-bis-(aryl)silyl-(C1-C7)-alkyl, (C1- C7)-Alkylcarbonyloxy-(C1-C7)-alkyl, (C3-C7)-Cycloalkylcarbonyloxy-(C1-C7)-alkyl, Arylcarbonyloxy-(C1-C7)-alkyl, Heteroarylcarbonyloxy-(C1-C7)-alkyl, 25 Heterocyclylcarbonyloxy-(C1-C7)-alkyl, Aryloxy-(C1-C7)-alkyl, Heteroaryloxy-(C1-C7)-alkyl, (C1-C7)-Alkoxycarbonyl steht und wobei Heterocyclyl n Oxogruppen trägt und wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl und (C1- C8)-Alkylsulfonyl, 30 R 14für (C1-C7)-Alkyl, (C2-C7)-Alkenyl, (C2-C7)-Alkinyl, (C1-C7)-Cyanoalkyl, (C1-C7)-Haloalkyl, (C2-C7)-Haloalkenyl, (C3-C7)-Haloalkinyl, (C3-C7)-Cycloalkyl, (C4-C7)-Cycloalkenyl, (C4-C7)- Halocycloalkenyl, (C1-C7)-Alkoxy-(C1-C7)-alkyl, (C1-C7)-Alkoxy-(C1-C7)-haloalkyl, Aryl, Aryl- (C1-C7)-alkyl, Heteroaryl, Heteroaryl-(C1-C7)-alkyl, Heterocyclyl-(C1-C7)-alkyl, (C3-C7)-35 Cycloalkyl-(C1-C7)-alkyl, (C4-C7)-Cycloalkenyl-(C1-C7)-alkyl, Amino, Bis-[(C1-C7)- alkyl]amino, (C1-C7)-Alkyl-amino, Aryl-(C1-C7)-amino, Aryl-(C1-C6)-alkyl-amino, Aryl-[(C1- C7)-alkyl]amino; (C3-C7)-Cycloalkyl-amino, (C3-C7)-Cycloalkyl-[(C1-C7)-alkyl]amino, N- BCS241005-Abroad STR 379 Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl, N-Morpholinyl, wherein the last twelve mentioned residues are bonded only to sulfonyl groups and wherein heterocyclyl carries n oxo groups, and wherein cycloalkyl may be substituted by one or more substituents selected from a group consisting of (C1-C8)-alkyl, (C1-C8)-haloalkyl, halogen, cyano, carbamoyl and 5 (C1-C8)-alkylsulfonyl, R 15 and R 16 independently of each other stand for (C1-C7)-alkyl, (C3-C7)-cycloalkyl, aryl, heteroaryl, heterocyclyl and where heterocyclyl carries n oxo groups, or 10 R 15 and R 16 with the carbon atom to which they are bonded, they form a fully saturated monocyclic carbocycle of 3 to 7 members, R 17 , R 18 , R 19 and R 2015 and n represent 0, 1, or 2 independently of one another, representing hydrogen, halogen, (C1-C7)-alkyl, (C1-C7)-alkoxy, (C1-C7)-haloalkoxy, (C3-C7)-cycloalkyl, and (C1-C7)-haloalkyl. 20 3. Compounds of general formula (I) according to claim 1, wherein M represents one of the groups 25, where the dashed line marks the link to the rest of formula (I), R 1 R stands for aryl or heteroaryl, wherein the aryl or heteroaryl group may be further substituted by 1, 2, 30 or 3 independently chosen substituents bonded to ring carbon atoms 4 , BCS241005-Abroad STR 380 and wherein, if applicable, two adjacent substituents R 4with the ring carbon atoms to which they are bonded, can form a saturated, partially saturated or unsaturated 5- to 7-membered ring, optionally interrupted by heteroatoms and optionally further substituted, 5 or R 1 represents a five- or six-membered heterocyclyl, which may be saturated or partially saturated, which may contain one to four heteroatoms and which bears n oxo groups, wherein each heteroatom is independently chosen from a group consisting of oxygen, nitrogen, and sulfur, and wherein the heterocyclyl residue is optionally substituted 10 by one, two, or three substituents, which are independently chosen from a group consisting of (C1-C6)-alkyl, (C1-C6)-haloalkyl, (C1-C6)-cycloalkyl, (C1-C6)-alkoxy, (C1-C6)-alkoxy-(C1-C6)-alkyl, (C2-C6)-alkenyl, (C1-C6)-haloalkoxy, halogen, aryl, heteroaryl, (heterocyclyl)aryl; 15 R 2 stands for hydrogen, R 3für (C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, (C2-C6)-Alkenyl, R 13 O-(C1-C6)-alkyl, (C3-C6)- Cycloalkyl-(C1-C6)-alkyl steht, 20 R 4 für Halogen, Cyano, Thiocyanato, Isothiocyanato, Pentafluorsulfanyl, Nitro, Aryldiazo, NR 11 R 12 , OR 13 , SR 14 , S(O)R 14 , SO2R 14 , S(O)(=N-R 11 )R 14 , S(O)(=N-R 11 )OR 13 , OSO2-Aryl, OSO2- (C1-C6)-alkyl, OSO2-(C1-C6)-haloalkyl, OSO2-(C3-C6)-cycloalkyl, C(O)OR 13 , C(O)R 13 C(O)NR 11 R 12 , C(S)NR 11 R 12 , -C=NOR 13 , R 13 OOC-(C1-C6)-alkyl, R 13 O-(C1-C6)-alkyl, R 13 S-(C1- C6)-alkyl, R 13(O)C-(C1-C6)-alkyl, (C1-C6)-Alkyl, Cyano-(C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2- 25 C6)-Alkinyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C2-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, (C1-C6)- Haloalkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-haloalkyl, (C4-C6)-Cycloalkenyl- (C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-haloalkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-30 alkyl, Aryl-(C1-C6)-alkinyl, Heteroaryl-(C1-C6)-alkinyl, Heterocyclyl-(C1-C6)-alkinyl, Tris-[(C1- C6)-alkyl]silyl-(C2-C6)-alkinyl, Bis-[(C1-C6)-alkyl](aryl)silyl-(C2-C6)-alkinyl, Bis-aryl[(C1-C6)- alkyl]silyl-(C2-C6)-alkinyl, (C3-C6)-Cycloalkyl-(C2-C6)-alkinyl, Aryl-(C2-C6)-alkenyl, Heteroaryl-(C2-C6)-alkenyl, Heterocyclyl-(C2-C6)-alkenyl, (C3-C6)-Cycloalkyl-(C2-C6)-alkenyl, Cyano-(C3-C6)-Cycloalkylaminosulfonylamino, Tris-[(C1-C6)-alkyl]silyl,Bis-[(C1-C6)-35 alkyl](aryl)silyl, Bis-aryl[(C1-C6)-alkyl]silyl stands and wherein heterocyclyl carries n oxo groups and wherein cycloalkyl may be substituted by one or more substituents selected from a group consisting of (C1-C8)-alkyl, (C1-C8)-haloalkyl, halogen, cyano, carbamoyl, BCS241005-Abroad STR 381 and (C1-C8)-alkylsulfonyl and wherein aryl or heteroaryl groups may be substituted by one or two alkoxycarbonyl groups, R 5 , R 6 independently of each other stand for hydrogen, halogen, (C1-C6) alkyl, preferably 5 hydrogen, R each 7 for hydrogen, halogen, (C1-C6)-alkyl, (C1-C7)-alkoxy, (C1-C7)-haloalkoxy, (C3-C6)-cycloalkyl, (C1-C6)-haloalkyl, 10 Q stands for hydroxy or a residue of the following formulas Q -1 Q-2 steht, R 8 for hydrogen, (C1-C6)-alkyl, (C1-C6)-haloalkyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, (C2-C6)-alkynyl, (C2-C6)-alkenyl, C(O)R 13, C(O)OR 13 , (C1-C6)-Alkoxy-(C1-C6)-alkyl steht, 15 R 9 für Wasserstoff oder (C1-C6)-Alkyl steht, R 10 für Wasserstoff, Halogen, Cyano, NO2, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C3-C6)-Halocycloalkyl, (C3-C6)-Halocycloalkyl-(C1-C6)-20 alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1- C6)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-alkyl, R 11 R 12 N-(C1-C6)-alkyl, R 13 O-(C1-C6)-alkyl, Cyano-(C1-C6)-alkyl, (C1-C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- carbonyloxy-(C1-C6)-alkyl, Arylcarbonyloxy-(C1-C6)-alkyl, Heteroarylcarbonyloxy-(C1-C6)- alkyl, Heterocyclylcarbonyloxy-(C1-C6)-alkyl, OR 13 , NR 11 R 12 , SR 14 , S(O)R 14 , SO2R 14 , R 14 S-(C1- 25 C6)-alkyl, R 14 (O)S-(C1-C6)-alkyl, R 14O2S-(C1-C6)-alkyl, tris-[(C1-C6)-alkyl]silyl-(C1-C6)-alkyl, bis-[(C1-C6)-alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, Tris-[(C1-C6)-alkyl]silyl, bis-hydroxyboryl-(C1-C6)-alkyl, bis-[(C1-C6)-alkoxy]boryl-(C1-C6)-alkyl, tetramethyl-1,3,2-dioxaborolan-2-yl, Tetramethyl-1,3,2-dioxaborolan-2-yl-(C1-C6)-alkyl, nitro-(C1-C6)-alkyl, C(O)OR 13 , C(O)R 13 , C(O)NR 11 R 12 , R 13 O(O)C-(C1-C6)-alkyl, R 11 R 12 N(O)C- 30 (C1-C6)-alkyl, bis-(C1-C6)-alkoxy-(C1-C6)-alkyl, and wherein heterocyclyl carries n oxo groups, or BCS241005-Abroad STR 382 R 8 and R 10 with the carbon atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted, 3 to 10-membered monocyclic or bicyclic ring, 5 R 11 and R 12gleich oder verschieden sind und unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4- C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1- C6)-Alkylthio-(C1-C6)-alkyl, (C1-C6)-Haloalkylthio-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-10 haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- (C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, COR 13 , SO2R 14, heterocyclyl, (C1-C6)-alkoxycarbonyl, bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-alkyl-amino-carbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxycarbonyl, heteroaryl-(C1-C6)-alkoxycarbonyl, (C2-C6)-alkenyloxycarbonyl, (C2-C6)-15 alkynyloxycarbonyl, heterocyclyl-(C1-C6)-alkyl and where heterocyclyl carries n oxo groups, or R 11 and R 12 with the nitrogen atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted 20, 3 to 10-membered monocyclic or bicyclic ring, R 13für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)- Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl,25 (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)- Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)- alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, Aryl, Aryl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxy-(C1-C6)- alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)- Cycloalkenyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-Alkyl-30 aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Bis-[(C1-C6)- alkyl]amino-(C2-C6)-alkyl, (C1-C6)-Alkyl-amino-(C2-C6)-alkyl, Aryl-(C1-C6)-alkyl-amino-(C2- C6)-alkyl, R 14 S-(C1-C6)-alkyl, R 14 (O)S-(C1-C6)-alkyl, R14 O2S-(C1-C6)-alkyl, Hydroxycarbonyl- (C1-C6)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl, Bis-[(C1-C6)-Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, (C1- 35 C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkylcarbonyloxy-(C1-C6)-alkyl, Arylcarbonyloxy-(C1-C6)-alkyl, Heteroarylcarbonyloxy-(C1-C6)-alkyl, Heterocyclylcarbonyloxy-(C1-C6)-alkyl, Aryloxy-(C1-C6)-alkyl, Heteroaryloxy-(C1-C6)-alkyl, BCS241005-Ausland STR 383 (C1-C6)-Alkoxycarbonyl steht und wobei Heterocyclyl n Oxogruppen trägt und wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl und (C1- C8)-Alkylsulfonyl, 5 R 14für (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)- Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1- C6)-haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, Heterocyclyl-(C1-10 C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, Amino, Bis- [(C1-C6)-alkyl]amino, (C1-C6)-Alkyl-amino, Aryl-(C1-C6)-amino, Aryl-(C1-C6)-alkyl-amino, Aryl-[(C1-C6)-alkyl]amino; (C3-C6)-Cycloalkyl-amino, (C3-C6)-Cycloalkyl-[(C1-C6)- alkyl]amino;N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl, N-Morpholinyl, wherein the last twelve residues are bonded only to sulfonyl groups and wherein Heterocyclyl carries n 15 oxo groups, and wherein Cycloalkyl may be substituted by one or more substituents selected from a group consisting of (C1-C8)-alkyl, (C1-C8)-haloalkyl, halogen, cyano, carbamoyl and (C1-C8)-alkylsulfonyl, R; 15 and R 16 independently of each other stand for (C1-C6)-alkyl, (C3-C6)-cycloalkyl, aryl, heteroaryl, 20 heterocyclyl and where heterocyclyl carries n oxo groups, or R 15 and R 16 with the carbon atom to which they are bonded, form a fully saturated monocyclic carbocycle of 3 to 7 members, 25 R 17 , R 18 , R 19 and R 20independently of one another stand for hydrogen, halogen, (C1-C6)-alkyl, (C1-C6)-alkoxy, (C1-C6)-haloalkoxy, (C3-C6)-cycloalkyl, (C1-C6)-haloalkyl, and 30 n stands for 0, 1, or 2.

4. Compounds of general formula (I) according to claim 1, wherein M represents one of the groups BCS241005-Abroad STR 384 M -1 M-2 M-3 stands, where the dashed line marks the point of connection to the rest of formula (I), 5 R 1 R stands for aryl or heteroaryl, wherein the aryl or heteroaryl group may be further substituted by 1, 2 or 3 independently chosen substituents bonded to ring carbon atoms 4 , 10 and where, if applicable, two adjacent substituents R 4with the ring carbon atoms to which they are bonded, can form a saturated, partially saturated or unsaturated 5- to 7-membered ring, optionally interrupted by heteroatoms and optionally further substituted, 15 or R 1 stands for a five- or six-membered heterocyclyl, which may be saturated or partially saturated, which may contain one to four heteroatoms and which bears n oxo groups, wherein each heteroatom is independently chosen from a group consisting of oxygen, nitrogen, and sulfur, and wherein the heterocyclyl residue is optionally substituted by one, two, or three substituents, which are independently chosen from a group consisting of (C1-C4)-alkyl, (C1-C4)-haloalkyl, (C1-C4)-cycloalkyl, (C1-C4)-alkoxy, (C1-C4)-alkoxy-(C1-C4)-alkyl, (C2-C4)-alkenyl, (C1-C4)-haloalkoxy, halogen, aryl, heteroaryl, (heterocyclyl)aryl; R 2 stands for hydrogen, 25 R 3für (C1-C6)-Alkyl, (C3-C6)-Cycloalkyl, (C2-C6)-Alkenyl, R 13 O-(C1-C6)-alkyl, (C3-C6)- Cycloalkyl-(C1-C6)-alkyl steht, R 4 für Halogen, Cyano, Thiocyanato, Isothiocyanato, Pentafluorsulfanyl, Nitro, Aryldiazo,30 NR 11 R 12 , OR 13 , SR 14 , S(O)R 14 , SO2R 14 , S(O)(=N-R 11 )R 14 , S(O)(=N-R 11 )OR 13 , OSO2-Aryl, OSO2- (C1C5)-alkyl, OSO2-(C1C5)-haloalkyl, OSO2-(C3C6)-cycloalkyl, C(O)OR 13 , C(O)R 13 , C(O)NR 11 R 12 , C(S)NR 11 R 12 , -C=NOR 13 , R 13 OOC-(C1-C6)-alkyl, R 13 O-(C1-C6)-alkyl, R 13 S-(C1- BCS241005-Ausland STR 385 C6)-alkyl, R 13(O)C-(C1-C6)-alkyl, (C1-C6)-Alkyl, Cyano-(C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2- C6)-Alkinyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C2-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, (C1-C6)- Haloalkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, 5 (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-haloalkyl, (C4-C6)-Cycloalkenyl- (C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-haloalkyl, Heterocyclyl, Heterocyclyl-(C1-C6)- alkyl, Aryl-(C1-C6)-alkinyl, Heteroaryl-(C1-C6)-alkinyl, Heterocyclyl-(C1-C6)-alkinyl, Tris-[(C1- C6)-alkyl]silyl-(C2-C6)-alkinyl, Bis-[(C1-C6)-alkyl](aryl)silyl-(C2-C6)-alkinyl, Bis-aryl[(C1-C6)- alkyl]silyl-(C2-C6)-alkinyl, (C3-C6)-Cycloalkyl-(C2-C6)-alkinyl, Aryl-(C2-C6)-alkenyl, 10 Heteroaryl-(C2-C6)-alkenyl, Heterocyclyl-(C2-C6)-alkenyl, (C3-C6)-Cycloalkyl-(C2-C6)-alkenyl, Cyano-(C3-C6)-Cycloalkylaminosulfonylamino, Tris-[(C1-C6)-alkyl]silyl,Bis-[(C1-C6)-alkyl](aryl)silyl, bis-aryl[(C1-C6)-alkyl]silyl, wherein heterocyclyl carries n oxo groups, and wherein cycloalkyl may be substituted by one or more substituents selected from a group consisting of (C1-C8)-alkyl, (C1-C8)-haloalkyl, halogen, cyano, carbamoyl 15, and (C1-C8)-alkylsulfonyl, and wherein aryl or heteroaryl groups may be substituted by one or two alkoxycarbonyl groups, R, 5 , R 6 stand for hydrogen, 20 R 7 Q represents hydrogen, halogen, (C1-C6)-alkyl, (C1-C6)-alkoxy, (C1-C6)-haloalkoxy, (C3-C6)-cycloalkyl, (C1-C6)-haloalkyl, Q represents hydroxy or a residue of the following formulas Q -1 Q-2 steht, 25 R 8 for hydrogen, (C1-C6)-alkyl, (C1-C6)-haloalkyl, aryl, aryl-(C1-C6)-alkyl, heteroaryl, (C2-C6)-alkynyl, (C2-C6)-alkenyl, C(O)R 13 , C(O)OR 13 , (C1-C6)-alkoxy-(C1-C6)-alkyl, R 9 for hydrogen or (C1-C6) alkyl, 30 R10 für Wasserstoff, Halogen, Cyano, NO2, (C1-C6)-Alkyl, (C1-C6)-Haloalkyl, (C3-C6)-Cycloalkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C3-C6)-Halocycloalkyl, (C3-C6)-Halocycloalkyl-(C1-C6)- alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1- C6)-alkyl, Heterocyclyl, Heterocyclyl-(C1-C6)-alkyl, R 11 R 12 N-(C1-C6)-alkyl, R 13 O-(C1-C6)-alkyl, BCS241005-Ausland STR 386 Cyano-(C1-C6)-alkyl, (C1-C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- carbonyloxy-(C1-C6)-alkyl, Arylcarbonyloxy-(C1-C6)-alkyl, Heteroarylcarbonyloxy-(C1-C6)- alkyl, Heterocyclylcarbonyloxy-(C1-C6)-alkyl, OR 13 , NR 11 R 12 , SR 14 , S(O)R 14 , SO2R 14 , R 14 S-(C1- C6)-alkyl, R 14 (O)S-(C1-C6)-alkyl, R 14O2S-(C1-C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl, 5 Bis-[(C1-C6)-Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, Tris-[(C1-C6)-alkyl]silyl, bis-hydroxyboryl-(C1-C6)-alkyl, bis-[(C1-C6)-alkoxy]boryl-(C1-C6)-alkyl, tetramethyl-1,3,2-dioxaborolan-2-yl, Tetramethyl-1,3,2-dioxaborolan-2-yl-(C1-C6)-alkyl, nitro-(C1-C6)-alkyl, C(O)OR 13 , C(O)R 13 , C(O)NR 11 R 12 , R 13 O(O)C-(C1-C6)-alkyl, R 11 R 12 N(O)C-(C1-C6)-alkyl, bis-(C1-C6)-alkoxy-(C1-C6)-alkyl, and wherein heterocyclyl n carries oxo groups 10, or R 8 and R 10 with the carbon atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted, 3 to 10-membered monocyclic or bicyclic ring, 15 R 11 and R 12gleich oder verschieden sind und unabhängig voneinander für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C3-C6)-Halocycloalkyl, (C4-C6)-Cycloalkenyl, (C4- C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-20 C6)-Alkylthio-(C1-C6)-alkyl, (C1-C6)-Haloalkylthio-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)- haloalkyl, Aryl, Aryl-(C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl- (C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, COR 13 , SO2R 14, heterocyclyl, (C1-C6)-alkoxycarbonyl, bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-alkyl-amino-carbonyl-(C1-C6)-alkyl, aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-25 alkoxycarbonyl, heteroaryl-(C1-C6)-alkoxycarbonyl, (C2-C6)-alkenyloxycarbonyl, (C2-C6)-alkynyloxycarbonyl, heterocyclyl-(C1-C6)-alkyl and where heterocyclyl carries n oxo groups, or R 11 and R 12 with the nitrogen atom to which they are bonded, form a fully saturated or partially saturated, optionally interrupted by heteroatoms and optionally further substituted, 3 to 10-membered monocyclic or bicyclic ring, R 13für Wasserstoff, (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)- Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, 35 (C4-C6)-Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Haloalkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)- Alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-alkoxy-(C1-C6)- BCS241005-Ausland STR 387 alkoxy-(C1-C6)-alkoxy-(C1-C6)-alkyl, Aryl, Aryl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkoxy-(C1-C6)- alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, (C3-C6)-Cycloalkyl-(C1-C6)-alkyl, (C4-C6)- Cycloalkenyl-(C1-C6)-alkyl, Bis-[(C1-C6)-alkyl]aminocarbonyl-(C1-C6)-alkyl, (C1-C6)-Alkyl- aminocarbonyl-(C1-C6)-alkyl, Aryl-(C1-C6)-alkyl-aminocarbonyl-(C1-C6)-alkyl, Bis-[(C1-C6)- 5 alkyl]amino-(C2-C6)-alkyl, (C1-C6)-Alkyl-amino-(C2-C6)-alkyl, Aryl-(C1-C6)-alkyl-amino-(C2- C6)-alkyl, R 14 S-(C1C6)-alkyl, R14 (O)S-(C1C6)-alkyl, R 14 O2S-(C1-C6)-alkyl, Hydroxycarbonyl- (C1-C6)-alkyl, Heterocyclyl, Heterocyclyl-(C1C6)-alkyl, Tris-[(C1-C6)-Alkyl]silyl-(C1-C6)-alkyl, Bis-[(C1-C6)-Alkyl](aryl)silyl(C1-C6)-alkyl, [(C1-C6)-Alkyl]-bis-(aryl)silyl-(C1-C6)-alkyl, (C1- C6)-Alkylcarbonyloxy-(C1-C6)-alkyl, (C3-C6)-Cycloalkylcarbonyloxy-(C1-C6)-alkyl, 10 Arylcarbonyloxy-(C1-C6)-alkyl, Heteroarylcarbonyloxy-(C1-C6)-alkyl, Heterocyclylcarbonyloxy-(C1-C6)-alkyl, Aryloxy-(C1-C6)-alkyl, Heteroaryloxy-(C1-C6)-alkyl, (C1-C6)-Alkoxycarbonyl steht und wobei Heterocyclyl n Oxogruppen trägt und wobei Cycloalkyl substituiert sein kann durch einen oder mehrere Substituenten ausgewählt aus einer Gruppe bestehend aus (C1-C8)-Alkyl, (C1-C8)-Haloalkyl, Halogen, Cyano, Carbamoyl und (C1- 15 C8)-Alkylsulfonyl, R 14für (C1-C6)-Alkyl, (C2-C6)-Alkenyl, (C2-C6)-Alkinyl, (C1-C6)-Cyanoalkyl, (C1-C6)-Haloalkyl, (C2-C6)-Haloalkenyl, (C3-C6)-Haloalkinyl, (C3-C6)-Cycloalkyl, (C4-C6)-Cycloalkenyl, (C4-C6)- Halocycloalkenyl, (C1-C6)-Alkoxy-(C1-C6)-alkyl, (C1-C6)-Alkoxy-(C1-C6)-haloalkyl, Aryl, Aryl-20 (C1-C6)-alkyl, Heteroaryl, Heteroaryl-(C1-C6)-alkyl, Heterocyclyl-(C1-C6)-alkyl, (C3-C6)- Cycloalkyl-(C1-C6)-alkyl, (C4-C6)-Cycloalkenyl-(C1-C6)-alkyl, Amino, Bis-[(C1-C6)- alkyl]amino, (C1-C6)-Alkyl-amino, Aryl-(C1-C6)-amino, Aryl-(C1-C6)-alkyl-amino, Aryl-[(C1- C6)-alkyl]amino; (C3-C6)-Cycloalkyl-amino, (C3-C6)-Cycloalkyl-[(C1-C6)-alkyl]amino;N-Azetidinyl, N-Pyrrolidinyl, N-Piperidinyl, N-Morpholinyl, wherein the last twelve 25 residues are only bonded to sulfonyl groups and wherein Heterocyclyl carries n oxo groups, and wherein Cycloalkyl may be substituted by one or more substituents selected from a group consisting of (C1-C8)-alkyl, (C1-C8)-haloalkyl, halogen, cyano, carbamoyl and (C1-C8)-alkylsulfonyl, 30 R; 15 and R 16 independently of each other stand for (C1-C6)-alkyl, (C3-C6)-cycloalkyl, aryl, heteroaryl, heterocyclyl and where heterocyclyl carries n oxo groups, or R 15 and R 16 with the carbon atom to which they are bonded, form a fully saturated monocyclic carbocycle of 3 to 7 members, 35 R 17 , R 18 , R 19 and R 20 independently of each other stand for hydrogen, halogen, (C1-C6)-alkyl, (C1-C6)-alkoxy, (C1-C8)-haloalkoxy, (C3-C6)-cycloalkyl, (C1-C6)-haloalkyl BCS241005-Abroad STR 388 and n stands for 0, 1 or 2. 5 5. Compounds of general formula (I) according to claim 1, wherein M stands for one of the groups M -1 M-2 M-3 10, where the dashed line marks the link to the rest of formula (I), R 1für Phenyl, 2-Methylphenyl, 3-Methylphenyl, 4-Methylphenyl, 2-Trifluormethylphenyl, 3-15 Trifluormethylphenyl, 4-Trifluormethylphenyl, 2-Trifluormethoxyphenyl, 3- Trifluormethoxyphenyl, 4-Trifluormethoxyphenyl, 2-Chlorphenyl, 3-Chlorphenyl, 4- Chlorphenyl, 3-Fluorphenyl, 4-Fluorphenyl, 2-Fluorphenyl, 2-Bromphenyl, 2-Iodphenyl, 3- Bromphenyl, 3-Iodphenyl, 4-Bromphenyl, 4-Iodphenyl, 2-Difluormethylphenyl, 2- Cyanophenyl, 3-Difluormethylphenyl, 3-Cyanophenyl, 4-Difluormethylphenyl, 4-Cyanophenyl, 20 2-Methoxyphenyl, 3-Methoxyphenyl, 4-Methoxyphenyl, 3,4-Difluorphenyl, 2,4-Difluorphenyl, 2,3-Difluorphenyl, 3,5-Difluorphenyl, 2,5-Difluorphenyl, 2,6-Difluorphenyl, 3,4-Dichlorphenyl, 2,4-Dichlorphenyl, 2,3-Dichlorphenyl, 3,5-Dichlorphenyl, 2,5-Dichlorphenyl, 2,6- Dichlorphenyl, 3,4-Dibromphenyl, 2,4-Dibromphenyl, 2,3-Dibromphenyl, 3,5-Dibromphenyl, 2,5-Dibromphenyl, 3,5-Diiodphenyl, 2,4-Diiodphenyl, 2,5-Diiodphenyl, 3,4-Diiodphenyl, 3-25 Fluor-4-chlorphenyl, 2-Fluor-4-chlorphenyl,2-Fluor-3-chlorphenyl, 2-Fluor-5-chlorphenyl, 3- Fluor-5-chlorphenyl, 2-Fluor-6-chlorphenyl, 3-Fluor-5-bromphenyl, 3-Fluor-5-iodphenyl, 3- Fluor-4-bromphenyl, 3-Fluor-4-iodphenyl, 2-Fluor-4-trifluormethylphenyl, 2-Fluor-4- methylphenyl, 2-Fluor-4-trifluormethoxyphenyl, 2-Fluor-4-trifluormethylsulfanylphenyl, 2- Fluor-4-cyanophenyl, 2-Fluor-4-methoxyphenyl, 2-Fluor-4-methoxycarbonylphenyl, 2-Fluor-4-30 hydroxycarbonylphenyl, 2-Fluor-6-trifluormethylphenyl, 2-Fluor-6-methylphenyl, 2-Fluor-6- trifluormethoxyphenyl, 2-Fluor-6-trifluormethylsulfanylphenyl, 2-Fluor-6-cyanophenyl, 2- Fluor-6-methoxyphenyl, 2-Fluor-6-methoxycarbonylphenyl, 2-Fluor-6-hydroxycarbonylphenyl, BCS241005-Ausland STR 389 3-Fluor-5-methoxycarbonylphenyl, 3-Fluor-5-hydroxycarbonylphenyl, 3-Fluor-5-cyanophenyl, 3-Fluor-5-methoxyphenyl, 3-Chlor-5-methoxyphenyl, 3-Brom-5-methoxyphenyl, 3-Iod-5- methoxyphenyl, 3-Chlor-4-fluorphenyl, 3-Brom-4-fluorphenyl, 3-Iod-4-fluorphenyl, 3-Brom-4- chlorphenyl, 3-Iod-4-chlorphenyl, 3-Iod-4-bromphenyl, 3-Iod-5-bromphenyl, 3-Brom-4- 5 iodphenyl, 4-Brom-3-chlorphenyl, 3-Chlor-4-iodphenyl, 3-Brom-5-chlorphenyl, 3-Chlor-5- iodphenyl, 3-Chlor-5-cyanophenyl, 3-Brom-5-cyanophenyl, 3-Iod-5-cyanophenyl, 2-Chlor-4- fluorphenyl, 2-Chlor-3-fluorphenyl, 2-Chlor-5-fluorphenyl, 3-Chlor-5-cyclopropylphenyl, 3-(1- Chlorcycloprop-1-yl)-5-chlorphenyl, 3-(1-Fluorcycloprop-1-yl)-5-chlorphenyl, 3-(1- Cyanocycloprop-1-yl)-5-chlorphenyl, 3-Cyclopropyl-5-fluorphenyl, 3-(1-Chlorcycloprop-1-yl)-10 5-fluorphenyl, 3-(1-Fluorcycloprop-1-yl)-5-fluorphenyl, 3-(1-Cyanocycloprop-1-yl)-5- fluorphenyl, 3-Cyclopropyl-5-bromphenyl, 3-Cyclopropyl-5-iodphenyl,3-(1-Chlorcycloprop-1- yl)-5-bromphenyl, 3-(1-Fluorcycloprop-1-yl)-5-bromphenyl, 3-(1-Cyanocycloprop-1-yl)-5- bromphenyl, 3-(1-Cyanocycloprop-1-yl)phenyl, 4-(1-Cyanocycloprop-1-yl)phenyl, 3-(1- Fluorcycloprop-1-yl)-5-iodphenyl, 3-(1-Fluorcycloprop-1-yl)-5-trifluormethylphenyl, 3-(1-15 Fluorcycloprop-1-yl)-5-trifluormethoxyphenyl, 3,4-Dimethylphenyl, 2,4-Dimethylphenyl, 2,3- Dimethylphenyl, 2,5-Dimethylphenyl, 2,6-Dimethylphenyl, 3-Fluor-4-methylphenyl, 3-Fluor-5- methoxyphenyl, 3-Fluor-4-methoxyphenyl, 3-Fluor-5-methylphenyl, 3,5-Dimethylphenyl, 3,5- bis(Trifluormethyl)phenyl, 2,5-bis(Trifluormethyl)phenyl, 2,4-bis(Trifluormethyl)phenyl, 2,6- bis(Trifluormethyl)phenyl, 2,3-bis(Trifluormethyl)phenyl, 3,5-bis(Difluormethyl)phenyl, 3,4-20 bis(Trifluormethyl)phenyl, 3,4-bis(Difluormethyl)phenyl, 2-Trifluormethyl-4-fluorphenyl, 3- Fluor-5-trifluormethylphenyl, 3-Chlor-5-trifluormethylphenyl, 3-Brom-5-trifluormethylphenyl, 3-Iod-5-trifluormethylphenyl, 3-Trifluormethyl-4-iodphenyl,3-Trifluormethyl-4-bromphenyl, 3- Trifluormethyl-4-trifluormethoxyphenyl, 3-Trifluormethyl-4-difluormethoxyphenyl, 3- Trifluormethyl-4-Cyanophenyl, 3-Trifluormethyl-4-methylphenyl, 3-Trifluormethyl-4-25 fluorphenyl, 3-Brom-4-trifluormethylphenyl, 3-Iod-4-Trifluormethylphenyl, 3-Methoxy-5- trifluormethylphenyl, 3-Methyl-5-trifluormethylphenyl, 3-Chlor-5-methylphenyl, 3-Brom-5- methylphenyl, 3-Iod-5-methylphenyl, 3-Difluormethoxy-5-trifluormethylphenyl, 3- Difluormethoxy-4-trifluormethylphenyl, 3-Difluormethoxy-5-trifluormethoxyphenyl, 3- Difluormethoxy-4-trifluormethoxyphenyl, 3-Difluormethoxyphenyl, 3-Chlor-5-30 difluormethoxyphenyl, 3-Chlor-4-difluormethoxyphenyl, 3-Difluormethoxy-4-chlorphenyl, 3- Brom-5-difluormethoxyphenyl, 3-Brom-4-difluormethoxyphenyl, 3-Difluormethoxy-4- bromphenyl, 3-Fluor-5-difluormethoxyphenyl, 3-Fluor-4-difluormethoxyphenyl, 3- Difluormethoxy-4-fluorphenyl, 3,5-bis(Difluormethoxy)phenyl, 3-Trifluormethoxy-5- trifluormethylphenyl,4-Chlor-3-trifluormethoxyphenyl, 3-Cyano-5-trifluormethylphenyl, 3-35 Chlor-5-prop-2-ylphenyl, 3-Chlor-5-ethylphenyl, 3-Prop-2-yl-5-trifluormethylphenyl, 3-Ethyl-5- trifluormethylphenyl, 3-Cyclopropyl-5-trifluormethylphenyl, 3-(1-Chlorycloprop-1-yl)-5- trifluormethylphenyl, 3-(1-Fluorycloprop-1-yl)-5-trifluormethylphenyl, 3-(1-Cyanoycloprop-1-, BCS241005-Ausland STR 390 yl)-5-trifluormethylphenyl, 2-Chlor-5-trifluormethylphenyl, 2-Chlor-4-trifluormethylphenyl, 3- Chlor-4-trifluormethylphenyl, 2-Chlor-6-trifluormethylphenyl, 2-Trifluormethyl-4-chlorphenyl, 3-Trifluormethyl-4-chlorphenyl, 2,3,4-Trifluorphenyl, 2,3,5-Trifluorphenyl, 3,4,5- Trifluorphenyl, 2,4,5-Trifluorphenyl, 2,3,6-Trifluorphenyl, 2,4,6-Trifluorphenyl, 3,4,5- 5 Trichlorphenyl, 3-Brom-4,5-dichlorphenyl, 3-Fluor-4,5-dichlorphenyl, 4-Brom-3,5- dichlorphenyl, 3,4-Dichlor-5-trifluormethylphenyl, 3,4-Dichlor-5-trifluormethoxyphenyl, 2- Fluor-3-methoxy-4-fluorphenyl, 2,4,6-Trimethylphenyl, 3,4,5-Trimethylphenyl, 2-Fluor-3- methylphenyl, 2-Fluor-6-methylphenyl, 2-Chlor-4,5-difluorphenyl, 2-Chlor-4-fluor-5- nitrophenyl, 2-Fluor-4-nitrophenyl, 2,4-Difluor-3-chlorphenyl, 2-Chlor-3,6-difluorphenyl, 2,3-10 Dichlor-6-fluorphenyl, 2-Chlor-4-cyanophenyl, 2-Ethyl-4,6-dimethylphenyl, 2-Fluor-6- ethoxycarbonylphenyl, 2-Fluor-6-isopropyloxyphenyl, 2,6-Difluor-3-methylphenyl, 2,6-Dichlor- 3-methylphenyl, Pyridin-2-yl, Pyridin-3-yl, 2-Fluorpyridin-3-yl, 2-Chlorpyridin-3-yl, 2,4- Difluorpyridin-3-yl, 2,4-Dichlorpyridin-3-yl, 2,6-Difluorpyridin-3-yl, 2,6-Dichlorpyridin-3-yl, 3,4-Difluorpyridin-2-yl, 3,4-Dichlorpyridin-2-yl, 3,5-Difluorpyridin-2-yl, 3,5-Dichlorpyridin-2-15 yl, 5-Chlorpyridin-2-yl, 6-Chlorpyridin-2-yl, 5-Fluorpyridin-2-yl, 6-Fluorpyridin-2-yl, 5,6- Difluorpyridin-2-yl, 5,6-Dichlorpyridin-2-yl, 4,6-Difluorpyridin-2-yl, 4,6-Dichlorpyridin-2-yl, 2,5-Difluorpyridin-3-yl, 2,5-Dichlorpyridin-3-yl, 4-Fluorpyridin-3-yl, 4-Chlorpyridin-3-yl, 5- Chlorpyridin-3-yl, 5-Brompyridin-3-yl, 4-Trifluormethylpyridin-3-yl, 4-Fluorpyridin-2-yl, 4- Chlorpyridin-2-yl, 4-Methylpyridin-2-yl, 4-Trifluormethylpyridin-2-yl, 4-Methoxypyridin-2-yl,20 4-Trifluormethoxypyridin-2-yl, 5-Trifluormethylpyridin-3-yl, 5-Trifluormethoxypyridin-3-yl, 5- Methoxypyridin-3-yl, 6-Chlorpyridin-3-yl, 6-Brompyridin-3-yl, 6-Trifluormethylpyridin-3-yl, 2- Trifluormethylpyridin-3-yl,3-Fluor-5-trifluormethoxyphenyl, 3-Chlor-5-trifluormethoxyphenyl, 3-Brom-5-trifluormethoxyphenyl, 3-Iod-5-trifluormethoxyphenyl, 3-Methyl-5- trifluormethoxyphenyl, 3-Cyano-5-trifluormethoxyphenyl, 3-(Prop-2-yl)-5-25 trifluormethoxyphenyl, 3-(Prop-1-yl)-5-trifluormethoxyphenyl, 3-(But-1-yl)-5- trifluormethoxyphenyl, 3-(1,1-Dimethyleth-1-yl)-5-trifluormethoxyphenyl, 3-Vinyl-5- trifluormethoxyphenyl, 3-(Prop-1-en-2-yl)-5-trifluormethoxyphenyl, 3-(Prop-1-en-1-yl)-5- trifluormethoxyphenyl, 3-(1-Methylprop-1-en-1-yl)-5-trifluormethoxyphenyl, 3-Ethyl-5- trifluormethoxyphenyl, 3-Cyclopropyl-5-trifluormethoxyphenyl, 3-Cyclobutyl-5-30 trifluormethoxyphenyl, 3-Cyclopentyl-5-trifluormethoxyphenyl, 3-Cyclopent-1-en-1-yl-5- trifluormethoxyphenyl, 3-trimethylsilyl-5-trifluormethoxyphenyl, 3-(1-Methylprop-1-yl)-5- trifluormethoxyphenyl, 3-(1-Methylprop-2-yl)-5-trifluormethoxyphenyl, 3-(1-Chlorycloprop-1- yl)-5-trifluormethoxyphenyl, 3-(1-Fluorycloprop-1-yl)-5-trifluormethoxyphenyl,3-(1- Cyanocycloprop-1-yl)-5-trifluormethoxyphenyl, 3-(1-Cyanocycloprop-1-yl)-4-35 trifluormethoxyphenyl, 3-(1-Cyanocycloprop-1-yl)-5-trifluormethylphenyl, 3-(1- Cyanocycloprop-1-yl)-4-trifluormethylphenyl, 3,5-bis(Trifluormethoxy)phenyl, 3,4- bis(Trifluormethoxy)phenyl, 3-Methoxymethyl-5-trifluormethoxyphenyl, 3,5-Dichlorpyridin-4-, BCS241005-Ausland STR 391 yl, 3,5-Difluorpyridin-4-yl, 3,5-Dibrompyridin-4-yl, 3,5-Dimethylpyridin-4-yl, 3,5- bis(trifluormethyl)pyridin-4-yl, 2,6-Dichlorpyridin-4-yl, 2,6-Difluorpyridin-4-yl, 2,6- Dibrompyridin-4-yl, 2,6-Dimethylpyridin-4-yl, 2,6-bis(trifluormethyl)pyridin-4-yl, 2- Chlorpyridin-4-yl, 2-Trifluormethylpyridin-4-yl, 3-Chlorpyridin-4-yl, 3-Trifluormethylpyridin- 5 4-yl, 3-Chlor-5-(pentafluor-λ⁶-sulfanyl)phenyl, 3-Fluor-5-(pentafluor-λ⁶-sulfanyl)phenyl, 3- Brom-5-(pentafluor-λ⁶-sulfanyl)phenyl, 1,3-Benzothiazol-5-yl, 1,3-Benzothiazol-6-yl, 2- Methoxy-1,3-benzothiazol-5-yl, 2-Methyl-1,3-benzothiazol-5-yl, 2-Chlor-1,3-benzothiazol-5-yl, Naphth-2-yl, Naphth-1-yl, 8-Bromnaphth-2-yl, 7-Bromnaphth-2-yl, 6-Bromnaphth-2-yl, 5- Bromnaphth-2-yl, 3-Chlor-5-methylsulfonylphenyl, 3-Chlor-4-(methylsulfonyl)phenyl, 3-Brom-10 5-methylsulfonylphenyl, 3-Brom-4-methylsulfonylphenyl, 3-Methylsulfonyl-4- trifluormethylphenyl, 3-(Methylsulfonyl)-4-chlorphenyl, 4-Brom-3-methylsulfonylphenyl,3- Chlor-5-(ethylsulfonyl)phenyl, 3-Chlor-5-(prop-2-ylsulfonyl)phenyl, 3-Chlor-5- (cyclopropylsulfonyl)phenyl, 3-Methylsulfonyl-5-trifluormethylphenyl, 3-Methylsulfonyl-5- trifluormethoxyphenyl, 3-Methylsulfonyl-5-(1H-pyrazol-1-yl)phenyl, 3-Methylsulfonyl-5-(1H-15 1,2,4-triazol-1-yl)phenyl, 3-Ethylsulfonyl-5-trifluormethoxyphenyl, 3-Ethylsulfinyl-5- trifluormethoxyphenyl, 3-Ethylsulfanyl-5-trifluormethoxyphenyl, 3-Chlor-5- (methylsulfinyl)phenyl, 3-Chlor-5-(ethylsulfinyl)phenyl, 3-Chlor-5-(prop-2-ylsulfinyl)phenyl, 3- Chlor-5-(cyclopropylsulfinyl)phenyl, 3-(Methylsulfinyl)-5-trifluormethylphenyl, 3- (Methylsulfinyl)-5-trifluormethoxyphenyl, 3-(Methylsulfinyl)-5-(1H-pyrazol-1-yl)phenyl, 3-20 (Methylsulfinyl)-5-(1H-1,2,4-triazol-1-yl)phenyl, 3-Chlor-5-(methylsulfanyl)phenyl, 3-Chlor-5- (ethylsulfanyl)phenyl, 3-Chlor-5-(prop-2-ylsulfanyl)phenyl, 3-Chlor-5- (cyclopropylsulfanyl)phenyl, 3-(Methylsulfanyl)-5-trifluormethylphenyl, 3-(Methylsulfanyl)-5- trifluormethoxyphenyl,3-(Methylsulfanyl)-5-(1H-pyrazol-1-yl)phenyl, 3-Methylsulfanyl-5-(1H- 1,2,4-triazol-1-yl)phenyl, 2,3-Dihydro-1,4-benzodioxin-6-yl, 1,1,4,4-Tetraoxido-2,3-dihydro-25 1,4-benzodithiin-6-yl, 1,1,4-Trioxido-2,3-dihydro-1,4-benzodithiin-6-yl, 1,4,4-Trioxido-2,3- dihydro-1,4-benzodithiin-6-yl, 1,4-Dioxido-2,3-dihydro-1,4-benzodithiin-6-yl, 2,3-dihydro-1,4- benzodithiin-6-yl, 1,1,3,3-Tetraoxido-1,3-benzodithiol-5-yl, 1,1,3-trioxido-1,3-benzodithiol-5- yl, 1,3-dioxido-1,3-benzodithiol-5-yl, 1,3-benzodithiol-5-yl, 2,3-dihydro-1,4-benzoxathiin-6-yl, 2,3-dihydro-1,4-benzoxathiin-7-yl, 4,4-dioxido-2,3-dihydro-1,4-benzoxathiin-7-yl, 4,4-dioxido-30 2,3-dihydro-1,4-benzoxathiin-6-yl, 3,3-dioxido-1,3-benzoxathiol-5-yl, 3-Oxido-1,3- benzoxathiol-5-yl, 1,3-Benzoxathiol-5-yl, 3,3-dioxido-1,3-benzoxathiol-6-yl, 3-Oxido-1,3- benzoxathiol-6-yl, 1,3-Benzoxathiol-6-yl, 3,5-bis(Methylsulfonyl)phenyl, 3,4- bis(Methylsulfonyl)phenyl, 3,5-bis(Methylsulfanyl)phenyl, 3,4-bis(Methylsulfanyl)phenyl,3-(4- Chlor-1H-pyrazol-1-yl)phenyl, 3-(4-Brom-1H-pyrazol-1-yl)phenyl, 3-(4-Iod-1H-pyrazol-1-35 yl)phenyl, 3-(4-Methyl-1H-pyrazol-1-yl)phenyl, 3-(4-Trifluormethyl-1H-pyrazol-1-yl)phenyl, 3- (1H-pyrazol-1-yl)phenyl, 3-(1H-pyrazol-1-yl)-5-chlorphenyl, 3-(1H-pyrazol-1-yl)-5- trifluormethylphenyl, 3-(1H-pyrazol-1-yl)-5-trifluormethoxyphenyl, 1,3-Benzodioxol-5-yl, 7-, BCS241005-Ausland STR 392 chlor-1,3-benzodioxol-5-yl, 6-chlor-1,3-benzodioxol-5-yl, 5-Methylpyrazin-2-yl, 5- Trifluormethylpyrazin-2-yl, 5-Fluorpyrazin-2-yl, 5-Chlorpyrazin-2-yl, 5-Brompyrazin-2-yl, Pyrazin-2-yl, Pyridazin-4-yl, Pyridazin-3-yl, 2-Methylpyrimidin-5-yl, Pyrimidin-5-yl, 3-Nitro-5- methoxyphenyl, 3-Nitro-4-methoxyphenyl, 3-Chlor-5-nitrophenyl, 3-Chlor-4-nitrophenyl, 3- 5 Nitro-4-chlorophenyl, 2-Nitro-5-trifluormethoxyphenyl, 3-Nitro-5-trifluormethylphenyl, 3- Nitro-4-trifluormethoxyphenyl, 3-Trifluormethyl-4-nitrophenyl, 3-Nitro-5- trifluormethoxyphenyl, 3-Nitrophenyl, 3-Phenyl-5-trifluormethylphenyl, 3- Methoxycarbonylphenyl-5-trifluormethylphenyl, 3,5-bis-(Trifluormethansulfonyl)phenyl, 3- Fluor-5-[(trifluormethyl)sulfonyl]phenyl, 3-Chlor-5-[(trifluormethyl)sulfonyl]phenyl, 3-Brom-5-10 [(trifluormethyl)sulfonyl]phenyl, 3-[(1-Cyanocycloprop-1-yl)-1-sulfonyl]-5- trifluormethoxyphenyl, 3-(1-Carbamoylcyclopropyl)-5-Trifluormethylsulfonylphenyl,3-(2- Cyanopropyl-2-sulfonyl)-5-trifluormethoxyphenyl, 3-(1-Cyano-1-methyleth-1-yl)-5- trifluormethylsulfonylphenyl, 3-(1-Cyanocycloprop-1-yl)-5-(trifluormethylsulfonyl)phenyl, 3- (1-Cyano-1-methyleth-1-yl)-5-trifluormethylphenyl, 3-(1-Cyano-1-methyl-ethyl)-5-15 trifluormethoxyphenyl, 3-[(Difluormethyl)sulfonyl]-5-trifluormethoxyphenyl, 3,5-bis- (difluormethylsulfonyl)phenyl, 3-(1-Methylsulfonylcyclopropyl)-5-trifluormethoxyphenyl, 3- Cyclopropylsulfamoyl-5-trifluormethoxyphenyl, 3-Methylsulfamoyl-5-trifluormethoxyphenyl, 3-Sulfamoyl-5-trifluormethoxyphenyl, 3-(1-methyl-1-methylsulfonylethyl)-5- trifluormethoxyphenyl, 3-Brom-5-[Brom(difluor)methyl]phenyl, 3-Chlor-5-20 [chlor(difluor)methyl]phenyl, 3-Chlor-5-(2-chlor-1,1,2,2-tetrafluorethoxyphenyl, 3-(1- Methylsulfonylcyclopropyl)-5-trifluormethylphenyl, 3-Chlor-5-[1- (trifluormethyl)cyclopropyl]phenyl, 3-Brom-5-[1-(trifluormethyl)cyclopropyl]phenyl, 3-Bromo- 5-(2,2-dichlorcyclopropyl)phenyl, 3-Chlor-5-(2,2-dichlorcyclopropyl)phenyl,3-Fluor-5-(2,2- dichlorcyclopropyl)phenyl, 3-Cyclopropylsulfonyl-5-trifluormethoxyphenyl, 3- 25 Cyclobutylsulfonyl-5-trifluormethoxyphenyl, 3-[(Prop-1-yl)sulfonyl]-5-trifluormethoxyphenyl, 3-[Prop-2-ylsulfonyl]-5-trifluormethoxyphenyl, 3-[1-Methyl-1-(methylsulfonyl)ethyl]-5- trifluormethylphenyl, 3-Methylsulfonyl-5-(1,1,2,2-tetrafluorethoxy)phenyl, 3-Brom-5-(1,1,2,2- tetrafluorethoxy)phenyl, 3,5-bis-(1,1,2,2-tetrafluorethoxy)phenyl, 3-(trifluormethoxy)-5- vinylphenyl, 3-formyl-5-trifluormethoxyphenyl, 3-[(Z)-(methoxyimino)methyl]-5-30 trifluormethoxyphenyl, 3-[(E)-(methoxyimino)methyl]-5-trifluormethoxyphenyl, 3-[(Z)- (ethoxyimino)methyl]-5-trifluormethoxyphenyl, 3-[(E)-(ethoxyimino)methyl]-5- trifluormethoxyphenyl, 3-[(Z)-(hydroxyimino)methyl]-5-trifluormethoxyphenyl, 3-[(E)- (hydroxyimino)methyl]-5-trifluormethoxyphenyl, 2-(2,2-Difluorcyclopropyl)phenyl, 2-(2,2- Dibromcyclopropyl)phenyl, 2-(2-Brom-2-Methylcyclopropyl)phenyl, 2-(2-35 Methylencyclopropyl)phenyl, 2-[1,1'-Bi(cyclopropyl)-1-yl]phenyl, 2-(Spiro[2.2]pentan-1- yl)phenyl, 3-(2,2-Difluorcyclopropyl)phenyl, 3-(2-Brom-2-Methylcyclopropyl)phenyl, 3-(2- Methylencyclopropyl)phenyl, 3-[1,1'-Bi(cyclopropyl)-1-yl]phenyl, 3-(Spiro[2.2]pentan-1-, BCS241005-Ausland STR 393 yl)phenyl, 3-Chlor-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-Brom-5-methyl-4,5-dihydro-1,2- oxazol-5-yl, 3,5-Dimethyl-4,5-dihydro-1,2-oxazol-5-yl, 3-Trifluormethyl-5-methyl-4,5-dihydro- 1,2-oxazol-5-yl, 3-(5-Amino-2-chlor-4-fluorphenyl)-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3- (5-Nitro-2-chlor-4-fluorphenyl)-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-[2-Chlor-5-(3,5- 5 dimethyl-2,6-dioxo-4-sulfanyliden-1,3,5-triazinan-1-yl)-4-fluorphenyl]-5-methyl-4,5-dihydro- 1,2-oxazol-5-yl, 3-{2-Chlor-4-fluor-5-[3-methyl-2,6-dioxo-4-(trifluormethyl)-3,6- dihydropyrimidin-1(2H)-yl]phenyl}-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-{2-Brom-4-fluor- 5-[3-methyl-2,6-dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}-5-methyl-4,5- dihydro-1,2-oxazol-5-yl, 3-{2-Iod-4-fluor-5-[3-methyl-2,6-dioxo-4-(trifluormethyl)-3,6-10 dihydropyrimidin-1(2H)-yl]phenyl}-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-{5-[3-Amino-2,6- dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]-2-chlor-4-fluorphenyl}-5-methyl-4,5- dihydro-1,2-oxazol-5-yl, 3-{5-[3-Amino-2,6-dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin- 1(2H)-yl]-2-brom-4-fluorphenyl}-5-methyl-4,5-dihydro-1,2-oxazol-5-yl, 3-{5-[3-Amino-2,6- dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]-2-iod-4-fluorphenyl}-5-methyl-4,5-15 dihydro-1,2-oxazol-5-yl, 2-{5-[3-Amino-2,6-dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin- 1(2H)-yl]-2-chlor-4-fluorphenyl}-1,3-thiazol-5-yl, 2-{5-[3-Amino-2,6-dioxo-4-(trifluormethyl)- 3,6-dihydropyrimidin-1(2H)-yl]-2-brom-4-fluorphenyl}-1,3-thiazol-5-yl, 2-{5-[3-Amino-2,6- dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]-2-iod-4-fluorphenyl}-1,3-thiazol-5-yl, 2-{2-Chlor-4-fluor-5-[3-methyl-2,6-dioxo-4-(trifluormethyl)-3,6-dihydropyrimidin-1(2H)-20 yl]phenyl}-1,3-thiazol-5-yl, 2-{2-Brom-4-fluor-5-[3-methyl-2,6-dioxo-4-(trifluormethyl)-3,6- dihydropyrimidin-1(2H)-yl]phenyl}-1,3-thiazol-5-yl, 2-{2-Iod-4-fluor-5-[3-methyl-2,6-dioxo-4- (trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}-1,3-thiazol-5-yl, 2-[2-Chlor-5-(3,5- dimethyl-2,6-dioxo-4-sulfanyliden-1,3,5-triazinan-1-yl)-4-fluorphenyl]-1,3-thiazol-5-yl, 1,3- Thiazol-5-yl, 1,3-Thiazol-4-yl, 2-Chlor-1,3-thiazol-5-yl, 2-Chlor-1,3-thiazol-4-yl, 2-Methyl-1,3- 25 thiazol-5-yl, 2-Methyl-1,3-thiazol-4-yl, 4-Methyl-1,3-thiazol-2-yl, 5-Methyl-1,3-thiazol-2-yl, Thien-2-yl, Thien-3-yl, 5-Chlorthien-2-yl, 5-Bromthien-2-yl, 4-Chlorthien-2-yl, 4-Bromthien-2- yl, 3-Chlorthien-2-yl, 3-Bromthien-2-yl, 4,5-Dichlorthien-2-yl, 4,5-Dibromthien-2-yl, 3,4- Dichlorthien-2-yl, 3,4-Dibromthien-2-yl, 4-Brom-3-methoxythien-2-yl, 4-Brom-3-methylthien- 2-yl, 5-(1-Cyanocycloprop-1-yl)thien-2-yl, 3-Trifluormethylthien-2-yl, 4-Trifluormethylthien-2-30 yl, 5-Trifluormethylthien-2-yl, 3-Trifluormethoxythien-2-yl, 4-Trifluormethoxythien-2-yl, 3- Difluormethoxythien-2-yl, 4-Difluormethoxythien-2-yl, 3-Difluormethoxy-5-methylthien-2-yl, 4-Chlorthien-3-yl, 5-Chlorthien-3-yl,2-Chlorthien-3-yl, 4-Bromthien-3-yl, 4-Methylthien-3-yl, 2,4-Dichlorthien-3-yl, 2,5-Dichlorthien-3-yl, 1-Methyl-1H-pyrazol-5-yl, 1-Ethyl-1H-pyrazol-5- yl, 4-Chlor-1,3-Dimethyl-1H-pyrazol-5-yl, 1,3-Dimethyl-1H-pyrazol-5-yl, 4-Chlor-1H-pyrazol-35 5-yl, 1-Methyl-1H-pyrazol-4-yl, 4-Methyl-1,2,3-thiadiazol-5-yl, 3-Methyl-1,2-oxazol-5-yl, 4- Methyl-1,2-oxazol-5-yl, 5-Methyl-1,2-oxazol-3-yl, 4-Methyl-1,3-oxazol-5-yl, 4,5-Dichlor-1,2- thiazol-3-yl, 1,2-Thiazol-3-yl, 1,2-Thiazol-5-yl, 4-Chlor-1,2-thiazol-5-yl, 3-Chlor-1,2-thiazol-5-, BCS241005-Ausland STR 394 yl, 3,4-Dichlor-1,2-thiazol-5-yl, 3-Chlor-4-Cyano-1,2-thiazol-5-yl, 1,2-Benzoxazol-3-yl, 1,2- Benzothiazol-3-y1, 7-Chlor-1,2-benzothiazol-3-yl, 3-Trimethylsilyl-5-trifluormethylphenyl, 3,5- bis(Trimethylsilyl)phenyl, 3-(1,1-Dimethyleth-1-yl)-5-trifluormethyl, 3-Methylsulfonyl-5- (1,1,2,2-tetrafluoroethyl)phenyl, 3-Brom-5-(1,1,2,2-tetrafluoroethyl)phenyl, 3-Chlor-5-(1,1,2,2- 5 tetrafluoroethyl)phenyl 3-Fluor-5-(1,1,2,2-tetrafluoroethyl)phenyl, 3-Brom-5- cyclopropylsulfonylphenyl, 3-Cyclopropylsulfonyl-5-trimethylsilylphenyl, 3- Cyclopropylsulfonyl-5-trifluormethylphenyl, 3-[cyclopropyl(difluoro)methyl]-5- trifluoromethoxyphenyl, 3-[Cyclopropyl(difluor)methyl]-5-trifluoromethylphenyl, 3-Brom-5- [cyclopropyl(difluor)methyl]phenyl, 3-Chlor-5-[cyclopropyl(difluor)methyl]phenyl, 3-Fluor-5-10 [cyclopropyl(difluor)methyl]phenyl, 3-[Cyclopropyl(difluor)methyl]-5-methylsulfonylphenyl, 3- [Chlor(difluor)methyl]-5-methylsulfonylphenyl, 3,5-bis[Chlor(difluor)methyl]phenyl,3-(1,1- Difluoreth-1-yl)-5-trifluormethylphenyl, 3-(1,1-Difluoreth-1-yl)-5-trifluormethoxyphenyl, 3- (1,1-Difluoreth-1-yl)-5-chlorphenyl, 3-(1,1-Difluoreth-1-yl)-5-bromphenyl, 3- trifluormethylsulfanylphenyl, 3-trifluormethylsulfanyl-5-chlorphenyl, 3-trifluormethylsulfanyl- 15 5-fluorphenyl, 3-trifluormethylsulfanyl-5-bromphenyl, 3-trifluormethylsulfanyl-4-chlorphenyl, 3-trifluormethylsulfanyl-4-fluorphenyl, 3-trifluormethylsulfanyl-4-bromphenyl, 3-(4- Methoxycarbonylphenyl)-5-trifluormethylphenyl, 4-Chlor-3-nitrophenyl, 3-Chlor-4-nitrophenyl, 3-(Oxetan-3-yl)phenyl, 3-(3-Fluoroxetan-3-yl)phenyl, 3-(Oxetan-3-yl)-5-trifluormethoxyphenyl, 3-(3-Fluoroxetan-3-yl)-5-trifluormethylphenyl, 4-Trifluormethylsulfanylpyridin-3-yl, 5-20 Trifluormethylsulfanylpyridin-3-yl, 6-Trifluormethylsulfanylpyridin-3-yl, 3- (Methylsulfonyloxy)phenyl, 3-(Methylsulfonyloxy)-5-chlorphenyl, 3-(Methylsulfonyloxy)-5- trifluormethylphenyl, 3-(Methylsulfonyloxy)-5-trifluormethoxyphenyl,3- (Trifluormethylsulfonyloxy)phenyl, 3-(Trifluormethylsulfonyloxy)-5-chlorphenyl, 3- (Trifluormethylsulfonyloxy)-5-trifluormethylphenyl, 3-(Trifluormethylsulfonyloxy)-5-25 trifluormethoxyphenyl, 4-(Methylsulfonyloxy)phenyl, 3-(Methylsulfonyloxy)-4-chlorphenyl, 3- (Methylsulfonyloxy)-4-trifluormethylphenyl, 3-(Methylsulfonyloxy)-4-trifluormethoxyphenyl, 3-chlor-4-(Methylsulfonyloxy)phenyl, 3-Trifluormethyl-4-(methylsulfonyloxy)phenyl, 3- Trifluormethoxy-4-(methylsulfonyloxy)phenyl, 3-(3-Methyl-1,2,4-oxadiazol-5-yl)-5- (trifluormethoxy)phenyl, 3-Chlor-5-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl, 4-Chlor-3-(3-30 methyl-1,2,4-oxadiazol-5-yl)phenyl, 3-(5-Methyl-1,3,4-oxadiazol-2-yl)-5- (trifluormethoxy)phenyl, 3-Chlor-5-(5-methyl-1,3,4-oxadiazol-2-yl)phenyl, 4-Chlor-3-(5- methyl-1,3,4-oxadiazol-2-yl)phenyl, 3-(5-Methyl-1,2,4-oxadiazol-3-yl)-5- (trifluormethoxy)phenyl, 3-Chlor-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl, 4-Chlor-3-(5- methyl-1,2,4-oxadiazol-3-yl)phenyl, 3-(2,5-Dioxoimidazolidin-4-yl)-5-(trifluormethoxy)phenyl, 35 3-Chlor-5-(2,5-dioxoimidazolidin-4-yl)phenyl, 4-Chlor-3-(2,5-dioxoimidazolidin-4-yl)phenyl, 3-(5-Oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(5-oxo-4,5- dihydro-1H-1,2,4-triazol-3-yl)phenyl, 4-Chlor-3-(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-, BCS241005-Ausland STR 395 yl)phenyl, 3-(5-Oxo-4,5-dihydro-1H-pyrazol-3-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(5- oxo-4,5-dihydro-1H-pyrazol-3-yl)phenyl, 4-Chlor-3-(5-oxo-4,5-dihydro-1H-pyrazol-3- yl)phenyl, 3-(1,3-Thiazol-2-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(1,3-thiazol-2-yl)phenyl, 4-Chlor-3-(1,3-thiazol-2-yl)phenyl, 3-(2-Methyl-1,3-thiazol-5-yl)-5-(trifluormethoxy)phenyl, 3- 5 Chlor-5-(2-methyl-1,3-thiazol-5-yl)phenyl, 4-Chlor-3-(2-methyl-1,3-thiazol-5-yl)phenyl, 3-(1,3- Oxazol-2-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(1,3-oxazol-2-yl)phenyl, 4-Chlor-3-(1,3- oxazol-2-yl)phenyl, 3-(2-Methyl-1,3-oxazol-5-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(2- methyl-1,3-oxazol-5-yl)phenyl, 4-Chlor-3-(2-methyl-1,3-oxazol-5-yl)phenyl, 3-(2-Oxoazetidin- 1-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(2-oxoazetidin-1-yl)phenyl, 4-Chlor-3-(2-10 oxoazetidin-1-yl)phenyl, 3-(2-Oxopyrrolidin-1-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(2- oxopyrrolidin-1-yl)phenyl,4-Chlor-3-(2-oxopyrrolidin-1-yl)phenyl, 3-(2,4-Dioxoimidazolidin- 1-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(2,4-dioxoimidazolidin-1-yl)phenyl, 4-Chlor-3-(2,4- dioxoimidazolidin-1-yl)phenyl, 3-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-5- (trifluormethoxy)phenyl, 3-Chlor-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)phenyl, 4-Chlor-15 3-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)phenyl, 3-(6-Methyl-2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)-5-(trifluormethoxy)phenyl, 3-Chlor-5-(6-methyl-2,4-dioxo-3,4- dihydropyrimidin-1(2H)-yl)phenyl, 4-Chlor-3-(6-methyl-2,4-dioxo-3,4-dihydropyrimidin- 1(2H)-yl)phenyl, 4,5-Dichlor-2-hydroxyphenyl, 3,4-Dichlor-5-hydroxyphenyl, 3,4-Dichlor-2- hydroxyphenyl, 1,3-Benzoxathiol-6-yl, 3-Methylcarbonyl-5-nitrophenyl, 4,5-Dichlor-2-20 fluorphenyl, 3,4-Dichlor-2-fluorphenyl, 3,4-Dichlor-5-fluorphenyl, 2,2-Difluor-1,3- benzodioxol-5-yl, 3-(1-Methylcycloprop-1-yl)-5-fluorphenyl, 3-(1-Methylcycloprop-1-yl)-5- chlorphenyl, 3-(1-Methylcycloprop-1-yl)-5-bromphenyl,3-(1-Methylcycloprop-1-yl)-5- trifluormethylphenyl, 3-(1-Methylcycloprop-1-yl)-5-trifluormethoxyphenyl, 3- (Methylaminocarbonyl)-5-trifluormethoxyphenyl, 3-(Ethylaminocarbonyl)-5-25 trifluormethoxyphenyl, 3-(Prop-2-ylaminocarbonyl)-5-trifluormethoxyphenyl, 3- (Cyclopropylaminocarbonyl)-5-trifluormethoxyphenyl, 3-Aminocarbonyl-5- trifluormethoxyphenyl, 3-(Methylaminocarbonyl)-5-trifluormethylphenyl, 3- (Ethylaminocarbonyl)-5-trifluormethylphenyl, 3-(Prop-2-ylaminocarbonyl)-5- trifluormethylphenyl, 3-(Cyclopropylaminocarbonyl)-5-trifluormethylphenyl, 3-Aminocarbonyl-30 5-trifluormethylphenyl, 3-(Methylaminocarbonyl)-5-chlorphenyl, 3-(Ethylaminocarbonyl)-5- chlorphenyl, 3-(Prop-2-ylaminocarbonyl)-5-chlorphenyl, 3-(Cyclopropylaminocarbonyl)-5- chlorphenyl, 3-Aminocarbonyl-5-chlorphenyl, 3-Methyl-5-phenyl-4,5-dihydro-1,2-oxazol-5-yl, 3-Methyl-4,5-dihydro-1,2-oxazol-5-yl steht, 35 R, 2 für Wasserstoff steht, BCS241005-Ausland STR 396 R 3für Methyl, Ethyl, Prop-1-yl, 1-Methylethyl, But-1-yl, 1-Methylprop-1-yl, 2-Methylprop-1-yl, 1,1-Dimethylethyl, Pent-1-yl, 1-Methylbut-1-yl, 2-Methylbut-1-yl, 3-Methylbut-1-yl, 1,1- Dimethylprop-1-yl, 1,2-Dimethylprop-1-yl, 2,2-Dimethylprop-1-yl, 1-Ethylprop-1-yl, Hex-1-yl, 1-Methylpent-1-yl, 2-Methylpent-1-yl, 3-Methylpent-1-yl, 4-Methylpent-1-yl, 1-Ethylbut-1-yl, 5 2-Ethylbut-1-yl, 1,2-Dimethylbut-1-yl, 1,3-Dimethylbut-1-yl, 2,2-Dimethylbut-1-yl, 3,3- Dimethylbut-1-yl, Cyclopropyl, Cyclobutyl, Cyclopentyl, Cyclohexyl, Methoxymethyl, Ethoxymethyl, Methoxyethyl, Ethoxyethyl, Cyclopropylmethyl, Cyclobutylmethyl, Cyclopentylmethyl, Cyclohexylmethyl, Vinyl, Prop-1-en-1-yl, Prop-2-en-1-yl, But-1-en-1-yl, But-2-en-1-yl, But-3-en-1-yl, Pent-1-en-1-yl, Pent-2-en-1-yl, Pent-3-en-1-yl, Pent-4-en-1-yl, 1- 10 Methylprop-2-en-1-yl, 2-Methylprop-2-en-1-yl, 1-Methylbut-2-en-1-yl, 2-Methylbut-2-en-1-yl, 3-Methylbut-2-en-1-yl, 1-Methylbut-3-en-1-yl, 2-Methylbut-3-en-1-yl, 3-Methylbut-3-en-1-yl, 1,1-Dimethylprop-2-en-1-yl, 1,2-Dimethylprop-2-en-1-yl, , stands, R, 5 , R 6 stand for hydrogen, 15 R 7 20 R stands for hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, prop-1-yl, prop-2-yl, cyclopropyl, cyclobutyl, methoxy, ethoxy, trifluoromethoxy, difluoromethoxy, difluoromethyl, trifluoromethyl 17 , R 18 , R 19 and R 20 independently of each other stand for hydrogen, fluorine, chlorine, bromine, iodine, methyl, ethyl, prop-1-yl, prop-2-yl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, methoxy, ethoxy, prop-1-yloxy, prop-2-yloxy, trifluoromethoxy, difluoromethoxy, difluoromethyl, trifluoromethyl, and 25 Q stands for a remainder of the following formulas Q-1 to Q-500 BCS241005-Abroad STR 397 5 BCS241005-Abroad STR 398 5 BCS241005-Abroad STR 399 5 BCS241005-Abroad STR 400 5 BCS241005-Abroad STR 401 5 BCS241005-Abroad STR 402 5 BCS241005-Abroad STR 403 5 BCS241005-Abroad STR 404 5 BCS241005-Abroad STR 405 5 BCS241005-Abroad STR 406 5 BCS241005-Abroad STR 407 5 BCS241005-Abroad STR 408 5 BCS241005-Abroad STR 409 5 BCS241005-Abroad STR 410 6. Compounds of general formula (I) according to claim 5, wherein 5 M for one of the groups M -1 M-2 M-3 stands, where the dashed line marks the link to the rest of formula (I), 10 R 1für 3,4-Dichlorphenyl, 3,5-Dichlorphenyl, 3,4-bis(Trifluormethyl)phenyl, 3,5- bis(Trifluormethyl)phenyl, 3-Trifluormethylphenyl, 4-Trifluormethylphenyl, 3-Chlor-5- trifluormethoxyphenyl, 2-(2,2-Dibromcyclopropyl)phenyl, 3-(1-Cyanocycloprop-1-yl)phenyl, 3- Chlor-5-trifluormethylphenyl, 4-Chlor-3-trifluormethoxyphenyl, 3-Chlor-5-iodphenyl, 3-Fluor-15 5-iodphenyl, 3-Iod-4-chlorphenyl, 3-Brom-4-chlorphenyl, 3-Fluor-5-trifluormethoxyphenyl, 3- Brom-5-trifluormethoxyphenyl, 3-(Prop-2-yl)-5-trifluormethoxyphenyl, 3-[(E)- (Methoxyimino)methyl]-5-trifluormethoxyphenyl, 3-Methyl-5-trifluormethoxyphenyl, 3-Cyano- 5-trifluormethoxyphenyl, 3-Nitrophenyl, 3-Nitro-5-trifluormethylphenyl, 3-(4- Methoxycarbonylphenyl)-5-trifluormethylphenyl, 3-Fluor-5-trifluormethylphenyl, 3-Brom-5-20 trifluormethylphenyl, 3-Trifluormethyl-4-chlorphenyl, 3-Chlor-4-trifluormethylphenyl, 3,4- Diiodphenyl, 3,5-Diiodphenyl, 3-(Methylsulfanyl)-5-(1H-pyrazol-1-yl)phenyl, 4-Chlor-3- nitrophenyl, 3-Chlor-4-nitrophenyl,5-Trifluormethylpyridin-3-yl, 2-Trifluormethylpyridin-4-yl, 5-Fluorpyrazin-2-yl, 6-Brompyridin-3-yl, 2,6-Difluorpyridin-4-yl, 3-Iod-5-trifluormethylphenyl, 3-Methylsulfonyl-5-trifluormethylphenyl, 3,5-bis(Trifluormethoxy)phenyl, 3-Difluormethoxy-5-25 trifluormethylphenyl, 3-Chlor-5-methylsulfonylphenyl, 3-Trifluormethoxyphenyl, 5- Trifluormethoxypyridin-3-yl, 3-Chlor-5-(pentafluor-λ⁶-sulfanyl)phenyl, 3-Fluor-5-(pentafluor- λ⁶-sulfanyl)phenyl, 3-Brom-5-(pentafluor-λ⁶-sulfanyl)phenyl, 3,5-bis(Methylsulfonyl)phenyl, 1,3-benzodithiol-5-yl, 2,3-dihydro-1,4-benzodithiin-6-yl, 2,6-bis(Trifluormethyl)phenyl, 3,4- Dibromphenyl, 3,5-bis(Methylsulfanyl)phenyl, 3,4-bis(Methylsulfanyl)phenyl, 2,3-Dihydro-1,4-30 benzoxathiin-7-yl, 2,3-Dihydro-1,4-benzoxathiin-6-yl, 1,3-Benzoxathiol-5-yl, 1,3-Benzoxathiol- 6-yl, 3-Chlor-5-cyclopropylphenyl, 3-Chlor-5-methoxyphenyl, 3-Brom-5-methoxyphenyl, 3- (1H-pyrazol-1-yl)phenyl, 3-Brom-5-methylsulfonylphenyl, 1,3-Benzodioxol-5-yl, 3-Chlor-5-, BCS241005-Ausland STR 411 nitrophenyl, 4-Brom-3-methylsulfonylphenyl, 3-Nitro-4-methoxyphenyl, 2-Methylpyrimidin-5- yl, 3-Fluor-4-methylphenyl, 4-Methoxypyridin-2-yl, 5-Methylpyrazin-2-yl, 3,4- bis(Methylsulfonyl)phenyl, 3,3-Dioxido-1,3-benzoxathiol-6-yl, 3-Oxido-1,3-benzoxathiol-6-yl, 4,4-Dioxido-2,3-dihydro-1,4-benzoxathiin-7-yl, 4,4-Dioxido-2,3-dihydro-1,4-benzoxathiin-6-yl, 5 3,3-Dioxido-1,3-benzoxathiol-5-yl, 1,1,3,3-Tetraoxido-1,3-benzodithiol-5-yl, 3-(4-Chlor-1H- pyrazol-1-yl)phenyl, 3-(4-Brom-1H-pyrazol-1-yl)phenyl, 3-(4-Iod-1H-pyrazol-1-yl)phenyl, 6- Chlor-1,3-benzodioxol-5-yl, 3-Brom-4-methylsulfonylphenyl, 6-Chlorpyridin-3-yl, 1,1,4,4- Tetraoxido-2,3-dihydro-1,4-benzodithiin-6-yl, 1,1,4-Trioxido-2,3-dihydro-1,4-benzodithiin-6-yl, 1,4,4-Trioxido-2,3-dihydro-1,4-benzodithiin-6-yl, 3-Ethylsulfonyl-5-trifluormethoxyphenyl, 6-10 Fluorpyridin-2-yl, 3,5-Dibromphenyl, 4-(1-Cyanocycloprop-1-yl)phenyl, 5-Brompyridin-3-yl, 3- Brom-4,5-dichlorphenyl, 3,4,5-Trichlorphenyl,3-(1-Cyanocycloprop-1-yl)-5-fluorphenyl, 3-(1- Cyanocycloprop-1-yl)-5-trifluormethoxyphenyl, 1,3-Benzothiazol-6-yl, 3-Chlor-5-cyanophenyl, 3-Methylsulfanyl-5-(1H-1,2,4-triazol-1-yl)phenyl, 2-Methyl-1,3-benzothiazol-5-yl, 2-Chlor-1,3- benzothiazol-5-yl, Naphth-2-yl, 3-Methylsulfonyl-5-(1H-1,2,4-triazol-1-yl)phenyl, 2-Methoxy-15 1,3-benzothiazol-5-yl, 4-Brom-3-chlorphenyl, 6-Bromnaphth-2-yl, 5-Bromnaphth-2-yl, 1,3- Benzothiazol-5-yl, 3-Methylsulfonyl-5-(1H-pyrazol-1-yl)phenyl, 2,3-Dichlorphenyl, 2,4- Dichlorphenyl, 2,5-Dichlorphenyl, 2,4-Dibromphenyl, 3,4-Difluorphenyl, 3,5-Difluorphenyl, 3,4-Dichlor-5-trifluormethoxyphenyl, 3-Iodphenyl, 4-Iodphenyl, 3-Chlor-1,2-thiazol-5-yl, 7- Chlor-1,2-benzothiazol-3-yl, 1,2-Benzoxazol-3-yl, 3,4-Dichlor-1,2-thiazol-5-yl, 4,5-Dichlor-1,2- 20 thiazol-3-yl, 3-Chlor-4-cyano-1,2-thiazol-5-yl, 1-Methyl-1H-pyrazol-5-yl, 5-Chlorthien-3-yl, 2,5-Dichlorthien-3-yl, 4-Methyl-1,2-oxazol-5-yl, 5-Methyl-1,2-oxazol-3-yl, 4-Methyl-1,3- oxazol-5-yl, 4-Methyl-1,2,3-thiadiazol-5-yl, 4-Methyl-1,3-thiazol-2-yl, 4-Chlor-1,3-Dimethyl- 1H-pyrazol-5-yl, 1,3-Thiazol-4-yl, 2-Chlor-1,3-thiazol-4-yl, 2-Chlor-1,3-thiazol-5-yl, 1,3- Thiazol-5-yl, 3-difluormethoxy-5-methylthien-2-yl, 3-Difluormethoxythien-2-yl, 4-Bromthien-25 3-yl, 3,4-Dibromthien-2-yl, 4-Brom-3-methoxythien-2-yl, 4-Brom-3-methylthien-2-yl, 5- Bromthien-2-yl, 4,5-Dichlorthien-2-yl, 5-Chlorthien-2-yl, 5-(1-cyanocycloprop-1-yl)thien-2-yl, 4,5-Dibromthien-2-yl, 3,5-Dimethyl-4,5-dihydro-1,2-oxazol-5-yl, 3-Trifluormethyl-5-methyl- 4,5-dihydro-1,2-oxazol-5-yl, 2,3-Dibromphenyl, 2,5-Dibromphenyl, 4-Brom-3,5-Dichlorphenyl, 2,3-Difluorphenyl, 3-Fluor-4-chlorphenyl, 3-Methylcarbonyl-5-nitrophenyl, 4,5-Dichlor-2-30 fluorphenyl, 3,4-Dichlor-2-fluorphenyl, 3,4-Dichlor-5-fluorphenyl, 2,2-Difluor-1,3- benzodioxol-5-yl, 3-(1-Methylcycloprop-1-yl)-5-trifluormethoxyphenyl, 3- (Methylaminocarbonyl)-5-trifluormethoxyphenyl, 2-{2-Chlor-4-fluor-5-[3-methyl-2,6-dioxo-4- (trifluormethyl)-3,6-dihydropyrimidin-1(2H)-yl]phenyl}-1,3-thiazol-5-yl, 3-[2-chloro-5-(3,5-dimethyl-2,6-dioxo-4-sulfanyliden-1,3,5-triazinan-1-yl)-4-fluorophenyl]-5-methyl-4,5-dihydro-35 1,2-oxazol-5-yl, 2-[2-Chloro-5-(3,5-dimethyl-2,6-dioxo-4-sulfanyliden-1,3,5-triazinan-1-yl)-4-fluorophenyl]-1,3-thiazol-5-yl, 3-Methyl-5-phenyl-4,5-dihydro-1,2-oxazol-5-yl, 3-Methyl-4,5- dihydro-1,2-oxazol-5-yl stands, BCS241005-Abroad STR 412 R 2 stands for hydrogen, R 3 stands for Methyl, Ethyl, Prop-1-yl, 1-Methyleth-1-yl, Cyclopropyl, Cyclobutyl, Vinyl, 5 R 5 , R 6 stand for hydrogen, R 7 10 R stands for hydrogen, fluorine, chlorine, methyl, methoxy 17 , R 18 , R 19 and R 20independently of each other stand for hydrogen, fluorine, chlorine, bromine, methyl, methoxy, and Q stands for a residue Q-1, Q-2, Q-23, Q-24, Q-26, Q-71, Q-72, Q-89, Q-91, Q-93, Q-115, Q-152, Q-176, Q-179, Q-286, Q-287, Q-301, Q-302, Q-371, Q-441, Q-442, Q-444, Q-471, Q-472, Q-481, Q-489, Q-490, Q-491, Q-499, Q-500.

7. Use of one or more compounds of general formula (I) and / or their salts according to any one of claims 1 to 6 as a herbicide and / or plant growth regulator, 20 preferably in crops of useful and / or ornamental plants.

8. Method for controlling weeds and / or regulating plant growth, characterized in that an effective amount of one or more compounds of general formula (I) and / or their salts according to any one of claims 1 to 6 25 is applied to the (weed) plants, (weed) plant seeds, the soil in which or on which the (weed) plants grow, or the cultivation area.

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