Inhibitors of lactate dehydrogenase, compositions comprising the inhibitor, and methods of use thereof

WO2025241047A1PCT designated stage Publication Date: 2025-11-27META PHARM (HK) LTD +1
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Patent Information

Application Number
PCT/CN2024/094117
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Filing Date
2024-05-20
Publication Date
2025-11-27

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Patent Text Reader

Abstract

The present disclosure provides novel substituted pyrrole compounds that can serve as inhibitors of lactate dehydrogenase, pharmaceutical compositions, comprising at least one of such novel substituted pyrrole compounds, and methods of using at least one of such compounds or compositions in treating or preventing diseases associated with lactate dehydrogenase activities, such as primary hyperoxaluria.
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Citation Information

Patent Citations

  • Treating primary or idiopathic hyperoxaluria with small molecule inhibitors of lactate dehydrogenase

    US20210369683A1

  • Small molecule inhibitors of lactate dehydrogenase and methods of use thereof

    WO2016109559A2

  • 1 h-pyrazol-1 -YL-thiazoles as inhibitors of lactate dehydrogenase and methods of use thereof

    WO2018005807A1

  • Substituted pyrazolyl compounds and methods of use thereof

    WO2021234543A1

  • Substituted pyrazolyl compounds and methods of use thereof

    WO2021234547A1