Organ transporter

Abstract

The present application relates to the field of organ transplantation. Disclosed is an organ transporter. The organ transporter of the present application comprises a transporter main body, an organ chamber and a perfusion assembly, wherein the transporter main body defines a functional cavity; the organ chamber is placed in the functional cavity, and is provided with a support member for carrying an isolated organ; and a part of the perfusion assembly is inserted into the organ chamber and is configured to be connected to the isolated organ so as to perform blood circulation on the isolated organ. The organ transporter is further provided with a driving assembly, wherein the driving assembly is arranged below the support member for driving the support member to drive the isolated organ to perform a reciprocating motion in the vertical direction. The organ transporter has a good preservation effect on organs, and can reduce damage during an organ transplantation transport process, thereby improving the success rate of organ transplantation.

Description

Organ transport machine TECHNICAL FIELD

[0001] The present application relates to the field of organ transplantation, and in particular to an organ transport machine. BACKGROUND

[0002] Organ transplantation technology replaces the organs lost due to diseases or injuries by transplanting healthy human organs into patients in need. From early kidney transplantation and liver transplantation to current lung transplantation and heart transplantation, the scope of organ transplantation is expanding, and the technology is becoming increasingly mature.

[0003] In the prior art, organ transplantation often adopts a "cold transplantation" technology, also known as ischemic transplantation or cryopreservation transplantation, which refers to the preparation and preservation of a transplanted organ through a large amount of perfusion fluid and cryopreservation. This technology preserves the organ in a low-temperature environment after the organ is removed from the human body to prolong the survival time of the organ, thereby facilitating transportation to the recipient's location. However, this preservation method can prolong the survival time of the organ, but due to complete interruption of blood supply to the organ, ischemic injury of the organ is inevitable, and the success rate of organ transplantation is not high and the therapeutic effect of transplantation is not good. SUMMARY

[0004] The present application aims to at least solve one of the technical problems existing in the prior art. To this end, the present application provides an organ transport machine, which has a good organ preservation effect, can reduce the damage during organ transplantation and transportation, and improve the success rate of organ transplantation.

[0005] The organ transport machine according to the first aspect of the present application comprises:

[0006] A machine body defining a functional cavity;

[0007] An organ compartment placed in the functional cavity, the organ compartment having a support for carrying an ex vivo organ;

[0008] A perfusion assembly partially inserted into the organ compartment for connection with the ex vivo organ to circulate blood in the ex vivo organ;

[0009] The organ transport machine further comprises a driving assembly arranged below the support to drive the support to reciprocally move the ex vivo organ in a vertical direction.

[0010] The organ transport machine according to the present application has at least the following beneficial effects:

[0011] The organ transport machine of the present application is not only provided with a perfusion assembly to maintain the activity of the isolated organ, but also provided with a driving assembly to drive the isolated organ to move to promote the blood circulation in the organ, so that the organ preservation effect of the organ transport machine is better, the damage in the organ transplantation and transport process can be reduced, and the success rate of organ transplantation is improved.

[0012] According to some embodiments of the present application, the organ container comprises a first box body and a second box body which can be closed, the supporting member is arranged in the first box body, and a protection member made of flexible material is further arranged in the organ container, the protection member can cover the isolated organ, so that the protection member and the supporting member jointly define the displacement of the isolated organ.

[0013] According to some embodiments of the present application, the supporting member is made of flexible material, and when the supporting member carries the isolated organ, the supporting member is deformed to be concave;

[0014] The driving assembly comprises a first air bag and a driving motor, the driving motor is used to drive the first air bag to reciprocate in the vertical direction, when the first air bag abuts against the supporting member and drives the supporting member to move upward, the supporting member gradually tends to be flat.

[0015] Alternatively, the driving assembly comprises a first air bag and a gas pump, the gas pump is used to inflate or deflate the first air bag, so that the volume of the first air bag increases or decreases, when the volume of the first air bag increases until the first air bag abuts against the supporting member and drives the supporting member to move upward, the supporting member gradually tends to be flat.

[0016] According to some embodiments of the present application, the perfusion assembly comprises a first blood supply pipe for connecting with the artery of the isolated organ, a second blood supply pipe for connecting with the portal vein of the isolated organ, and a first blood discharge pipe for connecting with the inferior vena cava of the isolated organ, the perfusion assembly further comprises a blood filter and a blood pump, the first blood discharge pipe communicates with the blood filter, the first blood supply pipe and the second blood supply pipe respectively communicate with the blood pump, and the blood pump is used to deliver the blood filtered by the blood filter back to the isolated organ.

[0017] According to some embodiments of the present application, the perfusion assembly further comprises a blood oxygen mixing module, the blood pump has a first branch pipe and a second branch pipe which are branched from the liquid outlet pipe, the first branch pipe and the second branch pipe are used to circulate non-oxygenated blood, the first branch pipe communicates with the blood oxygen mixing module, so that the non-oxygenated blood is converted into oxygenated blood, the blood oxygen mixing module has a third branch pipe and a fourth branch pipe which are branched from the liquid outlet pipe and are used to circulate the oxygenated blood, the second branch pipe and the third branch pipe both communicate with the second blood supply pipe, and the fourth branch pipe communicates with the first blood supply pipe.

[0018] According to some embodiments of the present application, the second branch pipe is provided with a first electric valve, the third branch pipe is provided with a second electric valve, and the organ transport machine further comprises a controller configured to control the opening degrees of the first electric valve and the second electric valve respectively, so as to adjust the proportion of oxygenated blood and non-oxygenated blood in the second blood supply pipe.

[0019] According to some embodiments of the present application, the organ transport machine has a pre-perfusion mode and a perfusion mode, in the pre-perfusion mode, the controller is configured to control the opening degrees of the first electric valve and the second electric valve respectively, so as to maintain the flow ratio of the first blood supply pipe and the second blood supply pipe between 1:3 and 1:4; in the perfusion mode, the controller is configured to control the opening degrees of the first electric valve and the second electric valve respectively, so as to maintain the blood oxygen saturation in the second blood supply pipe between 60% and 75%.

[0020] According to some embodiments of the present application, the perfusion assembly further comprises a first medicine feeder containing a first medicine, the first medicine feeder being in communication with the blood filter, so as to inject the first medicine into the blood in the blood filter;

[0021] And / or, the perfusion assembly further comprises a second medicine feeder containing a second medicine, the second medicine feeder being in communication with the first blood supply pipe, so as to inject the second medicine into the blood in the first blood supply pipe.

[0022] According to some embodiments of the present application, the organ transport machine further comprises a controller, the perfusion assembly comprises a second medicine feeder containing a second medicine, the second medicine feeder being in communication with the first blood supply pipe, the first blood supply pipe is provided with a first flow sensor configured to detect the flow in the first blood supply pipe, when the flow data detected by the first flow sensor is less than a first set value, the controller is configured to control the second medicine feeder to work, so as to inject the second medicine into the blood in the first blood supply pipe.

[0023] According to some embodiments of the present application, the perfusion assembly comprises a heating module and a blood-oxygen mixing module, the heating module is configured to supply heat to the blood-oxygen mixing module, so that the outlet liquid temperature of the blood-oxygen mixing module is within a first temperature range;

[0024] The perfusion assembly further comprises an oxygen production module, the oxygen production module comprises a first channel in communication with the functional cavity, a second channel in communication with the external environment, and a switching valve arranged at the intersection of the first channel and the second channel, the first channel and the second channel are configured to guide the heat generated by the oxygen production module out, and the organ transport machine further comprises a controller, the switching valve is controlled by the controller to adjust the opening degrees of the first channel and the second channel, so that the temperature in the functional cavity is within a first temperature range.

[0025] Additional aspects and advantages of the present application will be partially given in the following description, partially will become apparent from the following description, or will be learned by practice of the present application. BRIEF DESCRIPTION OF DRAWINGS

[0026] The present application will be further described below in conjunction with the accompanying drawings and embodiments, in which:

[0027] Fig. 1 is a structural schematic diagram of an organ transport machine according to an embodiment of the present application;

[0028] Fig. 2 is a schematic diagram of the connection relationship of an organ container, a driving assembly and a perfusion assembly according to an embodiment of the present application;

[0029] Fig. 3 is an enlarged schematic diagram of area A in Fig. 1;

[0030] Fig. 4 is an enlarged schematic diagram of area B in Fig. 1.

[0031] Reference signs: main body 100; functional cavity 110; second temperature sensor 111; organ container 200; first box 210; supporting member 211; second box 220; protection member 221; perfusion assembly 300; first blood supply pipe 310; first flow sensor 3101; first pressure sensor 3102; second blood supply pipe 311; second flow sensor 3111; second pressure sensor 3112; first blood discharge pipe 312; first liquid discharge pipe 313; second liquid discharge pipe 314; blood filter 320; blood pump 330; first branch pipe 331; second branch pipe 332; first electric valve 3321; blood-oxygen mixing module 340; third branch pipe 341; second electric valve 3411; fourth branch pipe 342; first temperature sensor 343; heating module 350; oxygen production module 360; first channel 361; second channel 362; switching valve 363; first medicine delivery device 370; second medicine delivery device 375; driving assembly 400; first air bag 410; driving motor 420; adapter 430; controller 500; display 550. DETAILED DESCRIPTION

[0032] The embodiments of the present application are described in detail below, examples of which are shown in the accompanying drawings, in which the same or similar notations represent the same or similar elements or elements having the same or similar functions throughout. The embodiments described below by reference to the accompanying drawings are exemplary only, and are used only for explanation of the present application, and cannot be understood as a limitation of the present application.

[0033] In the description of the present application, it needs to be understood that the orientation description, such as the orientation or position relationship indicated by the upper, lower, front, rear, left, right and the like, is based on the orientation or position relationship shown in the drawings, and is only for the convenience of describing the present application and simplifying the description, and cannot be understood as indicating or implying that the device or element indicated must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present application.

[0034] In the description of the present application, if one of several meanings is more than one, the meaning of multiple is more than two, greater than, less than, more than, and the like are understood as not including the number, above, below, and the like are understood as including the number. If it is described as first, second, it is only for the purpose of distinguishing technical features, and cannot be understood as indicating or implying relative importance or implicitly indicating the number of indicated technical features or implicitly indicating the sequence of indicated technical features.

[0035] In the description of the present application, unless otherwise explicitly limited, the words such as setting, installing, connecting and the like should be broadly understood, and those skilled in the art can reasonably determine the specific meaning of the above words in the present application in combination with the specific content of the technical solution.

[0036] In the description of the present application, the description of the terms "one embodiment", "some embodiments", "exemplary embodiment", "example", "specific example", or "some examples" means that the specific features, structures, materials or characteristics described in combination with the embodiment or example are included in at least one embodiment or example of the present application. In the specification, the exemplary description of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0037] Organ transplantation technology replaces the organs lost due to disease or injury in patients by transplanting healthy human organs into patients in need. From early kidney transplantation and liver transplantation to current lung transplantation and heart transplantation, the scope of organ transplantation is continuously expanding, and the technology is becoming increasingly mature.

[0038] In the prior art, organ transplantation often uses "cold transplantation" technology, also known as ischemic transplantation or cryopreservation transplantation, which means that the transplanted organ is prepared and preserved by a large amount of perfusion fluid and cryopreservation. This technology stores the organ in a low-temperature environment after the organ leaves the human body to prolong the survival time of the organ, thereby facilitating transportation to the recipient's location. However, this preservation method can prolong the survival time of the organ, but due to complete interruption of blood supply to the organ, ischemic injury of the organ is inevitable, and the success rate of organ transplantation is not high and the therapeutic effect of transplantation is not good.

[0039] To solve the above problems, the first aspect of the present application provides an organ transport machine, which comprises a machine body 100, an organ bin 200 and a perfusion assembly 300, wherein the machine body 100 defines a functional cavity 110 inside, and the organ bin 200 and the perfusion assembly 300 are arranged in the functional cavity 110. The organ bin 200 accommodates an isolated organ, which can be a heart, a liver, a kidney, etc. The organ bin 200 is provided with a supporting member 211 for carrying the isolated organ. The supporting member 211 is made of a flexible material such as silicone, PU (polyurethane), etc. Such flexible material is relatively soft and has good toughness and chemical resistance, which can softly support the isolated organ and is not easily corroded by blood, tissue fluid, etc.

[0040] It can be understood that the organ bin 200 is detachably connected with the machine body 100, and the organ bin 200 can be taken out of the machine body 100 to be placed near an operating table, so that the organ can be quickly placed in the organ bin 200 after being taken out of the human body, reducing the time of ischemia and hypoxia of the organ.

[0041] The perfusion assembly 300 is arranged in the functional cavity 110, and the liquid supply pipe and the liquid discharge pipe in the perfusion assembly 300 are inserted into the organ bin 200 and connected with the isolated organ, so that the blood circulation of the isolated organ can be realized, reducing the probability of damage to the isolated organ caused by ischemia. Taking the organ transport machine for liver transport shown in FIGS. 1 and 2 as an example, the liquid supply pipe of the perfusion assembly 300 comprises a first blood supply pipe 310 connected with the hepatic artery, a second blood supply pipe 311 connected with the portal vein of the liver, and a first blood discharge pipe 312 connected with the inferior vena cava of the liver. The perfusion assembly 300 further comprises a first liquid discharge pipe 313 for discharging liver permeate and a second liquid discharge pipe 314 for discharging bile, the first liquid discharge pipe 313 communicates with a blood filter 320, and the second liquid discharge pipe 314 communicates with a bile collection bag. The liquid supply pipe and the liquid discharge pipe of the perfusion assembly 300 are flexible pipes, which can move with the movement of the isolated organ to avoid damaging the organ. It can be understood that the specific number of each liquid supply pipe and liquid discharge pipe can be adjusted according to the perfusion demand of the isolated organ.

[0042] The perfusion assembly 300 further comprises a blood filter 320, an oxygen generation module 360, a blood pump 330 and other life support components, which are used to ensure that various parameters such as blood oxygen, temperature and nutrients during blood circulation are maintained within a set range, so that the isolated organ can maintain activity in vitro.

[0043] It should be noted that the organ transport machine of the present application further comprises a driving assembly 400 arranged below the supporting member 211 to drive the supporting member 211 to reciprocate the isolated organ in the vertical direction, so as to promote the blood circulation in the isolated organ and reduce the possibility of local blood vessel blockage.

[0044] Based on the above, it can be found that the organ transport machine not only is provided with the perfusion assembly 300 to maintain the activity of the isolated organ, but also is provided with the driving assembly 400 for driving the isolated organ to move to promote the blood circulation in the organ, and the organ preservation effect of the organ transport machine is better, and the damage in the organ transplantation and transport process can be reduced, and the success rate of organ transplantation can be improved.

[0045] In some embodiments, the organ container 200 comprises a first box 210 and a second box 220 which can be covered, in the embodiment as shown in FIG. 2, the first box 210 is a bottom base, the support 211 is arranged in the first box 210, and the second box 220 is a top cover, and the first box 210 and the second box 220 jointly define a containing cavity. The first box 210 and the second box 220 can be hingedly connected on one side, and detachably connected on the other side, so that the second box 220 can rotate relative to the first box 210 to open the containing cavity in the organ container 200. Alternatively, both sides of the first box 210 and the second box 220 can be detachably connected in a plug-in, lock-in or other connection manner, so that the second box 220 can be separated from the first box 210 to expose the containing cavity of the first box 210.

[0046] The containing cavity in the organ container 200 is also provided with a protection member 221 made of flexible material, and the manufacturing material of the protection member 221 can be the same as or different from that of the support 211, but also needs to have good toughness and chemical resistance. The protection member 221 can cover the isolated organ, so that the protection member 221 and the support 211 are respectively located on the upper and lower sides of the isolated organ to coat the isolated organ, and then jointly limit the displacement of the isolated organ to avoid collision damage of the isolated organ with the cavity wall of the containing cavity during the transport process.

[0047] It can be understood that the top of the first box 210 has a first opening, and the bottom of the second box 220 has a second opening, when the first box 210 and the second box 220 are covered, the first opening and the second opening are connected to each other, so that the first box 210 and the second box 220 define a closed containing cavity for containing the isolated liver.

[0048] It should be noted that in the embodiment shown in FIG. 2, the support 211 is arranged on the first box 210, and the protection 221 is arranged on the second box 220. After the isolated organ is placed on the support 211, the top of the isolated organ is exposed to the first opening. The protection 221 is arranged at the second opening of the second box 220. When the first box 210 and the second box 220 are closed, the protection 221 abuts against the isolated organ and deforms according to the shape of the top surface of the isolated organ, thereby covering the top surface of the isolated organ. The organ container 200 of this structure realizes fixation of the isolated organ when the first box 210 and the second box 220 are closed and locked, which is relatively convenient and fast to operate.

[0049] In some other embodiments (not shown in the drawings), the protection 221 is detachably connected with the first box 210. After the isolated organ is placed on the support 211, the protection 221 is covered on the isolated organ and is connected and fixed with the first box 210, and then the second box 220 is closed to form a sealed chamber. The organ container 200 of this structure has good adaptability to the isolated organ, and can adjust the abutting position and abutting force of the protection 221 and the isolated organ according to the size of the isolated organ.

[0050] In the related art, the isolated organ is flatly placed in the organ container 200. The bottom region of the isolated organ in contact with the support 211 is compressed by the weight of the isolated organ itself, and the perfused blood is difficult to pass through the bottom region of the organ which is compressed more seriously, resulting in local ischemia of the bottom of the organ and damage.

[0051] To ensure the blood flow of the bottom of the isolated organ, the following improvements are made in the present application: in some embodiments, the support 211 is made of flexible material, forming a thin film-shaped hanging bag structure as shown in FIG. 2. When the support 211 carries the isolated organ, the support 211 deforms concave downward. It can be understood that the support 211 will exert a normal pressure F on the isolated organ towards the contact point. The vertical component of the pressure F is used to balance the weight of the isolated organ, and the horizontal component of the pressure F becomes a harmful stress to squeeze the isolated organ. It can be understood that the greater the horizontal component, the more serious the internal squeezing of the isolated organ, and the greater the damage to the isolated organ. Therefore, the driving assembly 400 of the embodiment of the present application is used to drive the isolated organ to move in the up-down direction to change the internal stress, thereby producing an effect similar to massage, promoting the blood flow of the bottom of the isolated organ.

[0052] Specifically, the driving assembly 400 of the present application comprises a first air bag 410 and a driving motor 420. The first air bag 410 is arranged below the supporting member 211. In the initial state, the first air bag 410 can be in abutment with the supporting member 211 or can be arranged in a spaced manner with the supporting member 211. The driving motor 420 can be arranged in the functional cavity 110 or can be arranged outside the functional cavity 110 as shown in FIG. 1. The specific arrangement is determined according to the space design of the organ transport machine. The driving motor 420 is in transmission connection with the first air bag 410. The first air bag 410 is driven by the driving motor 420. The first air bag 410 can move towards the supporting member 211 until abutting with the supporting member 211. Then, the first air bag 410 drives the supporting member 211 to move reciprocatingly along the vertical direction under the driving of the driving motor 420. It can be understood that when the supporting member 211 is placed with the isolated organ, the supporting member 211 drives the isolated organ to move up and down, so as to promote the blood circulation in the isolated organ and reduce the possibility of local blood vessel occlusion.

[0053] In the embodiment as shown in FIG. 2, the driving assembly 400 comprises a motor arranged outside the functional cavity 110 and an adapter 430 penetrating the organ container 200. The adapter 430 is in abutment with the first air bag 410. The first air bag 410 is of a flexible structure and can be in flexible abutment with the supporting member 211, so as to avoid damaging the isolated organ when the first air bag 410 abuts with the supporting member 211.

[0054] Next, the abutment process of the first air bag 410 and the supporting member 211 and the blood circulation of the isolated organ are analyzed in detail with the embodiments as shown in FIG. 1 and FIG. 2 as examples.

[0055] Firstly, when the first air bag 410 is located at the lower limit position, the first air bag 410 is not in contact with or is not forced by the supporting member 211. At this time, the isolated organ is only in contact with the supporting member 211. The horizontal component force of the pressure F reaches the maximum, the internal extrusion force of the isolated organ reaches the maximum, the gravity and the internal extrusion force are all applied to the lower part of the isolated organ, so that the perfusion blood is more likely to pass through the capillary vessels in the upper part of the isolated organ with relatively small extrusion force, and the capillary vessels in the lower part of the isolated organ are difficult to flow with blood due to the relatively large internal stress, and are prone to ischemia.

[0056] When the first air bag 410 is driven to gradually move upwards, the contact area between the supporting member 211 and the first air bag 410 gradually increases, the supporting member 211 gradually tends to be flat, the horizontal component force of the contact point between the supporting member 211 and the isolated organ gradually decreases (the angle between the normal direction of the contact point and the horizontal direction increases), the internal extrusion force gradually decreases, and the isolated organ gradually spreads. The blood pressure difference in the capillary vessels in the isolated organ gradually decreases, and the perfusion blood in the entire isolated organ tends to be in the best state of circulation. Most of the cells of the isolated organ can obtain blood supply.

[0057] When the first air bag 410 reaches the upper limit position, the first air bag 410 has the largest contact area with the support 211, the horizontal component of the force of the support 211 on the isolated organ is zero, the internal pressure reaches the minimum, and the isolated organ is completely spread out. The pressure difference of the blood flowing in the capillary vessels of the isolated organ reaches the minimum, and the perfusion blood has the best flowability in the entire isolated organ. Most of the cells of the isolated organ can obtain sufficient blood supply.

[0058] When the first air bag 410 is driven to move downward from the upper limit position, the contact area of the first air bag 410 with the support 211 gradually decreases, the horizontal component of the force of the support 211 on the isolated organ gradually increases, the internal pressure gradually increases, and the blood flowability in the capillary vessels of different parts of the isolated organ changes. Under the action of the internal stress, the blood in a part of the capillary vessels accelerates, the blood in another part of the capillary vessels decelerates, and the blood flowability in a part of the capillary vessels remains unchanged. Due to the different flowabilities in the internal capillary vessels, the center of gravity of the isolated organ changes slightly, thereby changing the position of the maximum stress point of the isolated organ, and the cells bearing the maximum pressure change, thereby changing the blood supply state of the lower cells and ensuring that the lower cells do not appear in a state of long-term ischemia, thereby reducing cell damage.

[0059] When the first air bag 410 moves to the lower limit position and then continues to move upward to repeat the above process, after multiple reciprocating movements, the pressure and flow in the capillary vessels at the same position in the organ are not the same, thereby ensuring that most of the cells are in a state of not lacking blood.

[0060] It can be understood that, unlike the driving mode of the driving motor 420 driving the first air bag 410 to move shown in FIG. 2, in another embodiment (not shown in the figure), the driving assembly 400 includes the first air bag 410 and a gas pump, and the volume of the first air bag 410 is increased or decreased by the gas pump inflating or deflating the first air bag 410. In the initial state, the first air bag 410 can not abut against the support 211, and in the inflation process, the volume of the first air bag 410 gradually increases, the top end of the first air bag 410 gradually approaches the support 211 until it abuts against the support 211. With the continuous expansion of the first air bag 410, the first air bag 410 can drive the support 211 to move upward, and in this process, the support 211 gradually tends to be flat, and the horizontal component of the force of the support 211 on the isolated organ gradually decreases.

[0061] In some embodiments, the perfusion assembly 300 comprises a first blood supply tube 310 for connecting with an artery of the isolated organ, a second blood supply tube 311 for connecting with a portal vein of the isolated organ, and a first blood discharge tube 312 for connecting with an inferior vena cava of the isolated organ. It is noted that the perfusion assembly 300 further comprises a blood filter 320 and a blood pump 330, the blood filter 320 has a function of storing blood and filtering blood clots and organ shedding fragments in the blood. The blood pump 330 draws blood in the blood storage filter to simulate the pumping of blood in the manner of heart beating. The first blood discharge tube 312 is in communication with the blood filter 320, and the first blood supply tube 310 and the second blood supply tube 311 are respectively in communication with the blood pump 330, so that the blood discharged from the inferior vena cava is filtered by the blood filter 320 and then driven by the blood pump 330 to be delivered back to the isolated organ in the organ chamber 200.

[0062] Further, as shown in FIGS. 1-3, the perfusion assembly 300 further comprises a blood oxygen mixing module 340, and the liquid outlet pipe of the blood pump 330 branches into a first branch pipe 331 and a second branch pipe 332. It can be understood that the first branch pipe 331 and the second branch pipe 332 deliver blood discharged from the inferior vena cava, and the blood oxygen saturation of the blood is low. For the convenience of description, the blood that has not passed through the blood oxygen mixing module 340 is named as non-oxygenated blood, and the blood that has passed through the blood oxygen mixing module 340 is named as oxygenated blood. It can be understood that the blood oxygen saturation of the non-oxygenated blood is lower than that of the oxygenated blood, and thus the first branch pipe 331 and the second branch pipe 332 are both used for circulating non-oxygenated blood. The first branch pipe 331 is in communication with the blood oxygen mixing module 340 to convert the non-oxygenated blood into oxygenated blood, and the liquid outlet pipe of the blood oxygen mixing module 340 branches into a third branch pipe 341 and a fourth branch pipe 342. It can be understood that the third branch pipe 341 and the fourth branch pipe 342 circulate oxygenated blood.

[0063] It should be noted that the second branch pipe 332 and the third branch pipe 341 are both communicated with the second blood supply pipe 311 to mix the part of non-oxygenated blood and the part of oxygenated blood and then input the mixed blood into the portal vein through the second blood supply pipe 311. The fourth branch pipe 342 is communicated with the first blood supply pipe 310 to input the oxygenated blood into the organ artery. This design mode realizes the blood supply of the blood supply pipes with different blood oxygen saturation requirements through one blood oxygen mixing module 340, and accordingly, the perfusion assembly 300 also includes an oxygen production module 360 and a heating module 350 matched with the blood oxygen mixing module 340. Therefore, the oxygen production module 360 and the heating module 350 also only need to be provided one, which reduces the number of parts of the organ transport machine, is beneficial to reduce the size of the organ transport machine, and reduces the manufacturing cost of the organ transport machine. It should be explained that the oxygen production module 360 is used to supply oxygen to the blood oxygen mixing module 340, and the oxygen production module 360 can change the working state according to the set value to provide clean gas with different oxygen concentrations and flow rates. The heating module 350 is used to supply heat to the blood oxygen mixing module 340 to maintain the temperature of the oxygenated blood.

[0064] Further, the second branch pipe 332 is provided with a first electric valve 3321, the third branch pipe 341 is provided with a second electric valve 3411, and the organ transport machine also includes a controller 500. The controller 500 can control the opening degree of the first electric valve 3321 and the second electric valve 3411 respectively to adjust the proportion of oxygenated blood and non-oxygenated blood in the second blood supply pipe 311, so as to adjust the blood oxygen saturation of the blood supplied to the portal vein. It should be explained that the opening degree of the valve generally refers to the degree of opening or closing of the valve. The greater the opening degree, the greater the flow through the valve, and the smaller the opening degree, the smaller the flow through the valve.

[0065] It should be noted that in addition to being able to adjust the blood oxygen saturation in the second blood supply pipe 311, the first electric valve 3321 and the second electric valve 3411 can also be used to control the pressure and flow of the artery. Specifically, when the opening degree of the first electric valve 3321 and the second electric valve 3411 is reduced, the blood flow through the first electric valve 3321 and the second electric valve 3411 becomes smaller, so that the perfusion flow and perfusion pressure in the portal vein decrease. In the case that the blood pump 330 has a certain speed, that is, the total perfusion flow is certain, the perfusion flow and perfusion pressure in the artery increase. Conversely, if the opening degree of the first electric valve 3321 and the second electric valve 3411 is increased, the perfusion flow and perfusion pressure in the artery decrease.

[0066] In the embodiment shown in FIG. 1, the first blood supply vessel 310 is provided with a first pressure sensor 3102 and a first flow sensor 3101, and the second blood supply vessel 311 is provided with a second pressure sensor 3112 and a second flow sensor 3111, and the controller 500 can be communicatively connected with the first pressure sensor 3102, the first flow sensor 3101, the second pressure sensor 3112 and the second flow sensor 3111, respectively, so as to detect the blood pressure and blood flow in the portal vein and the artery in real time, so that the controller 500 can timely control.

[0067] Further, the organ transport machine has a pre-perfusion mode and a perfusion mode. It can be understood that before the organ transport machine is connected with the organ, the pre-perfusion mode needs to be run, so as to empty the air in the pipeline and test run the equipment. In the pre-perfusion mode, the controller 500 controls the opening degree of the first electric valve 3321 and the second electric valve 3411, respectively, so as to maintain the flow ratio of the first blood supply vessel 310 and the second blood supply vessel 311 between 1:3 and 1:4. When the isolated organ is placed in the organ bin 200 and connected with the pipelines, the organ transport machine is switched to the perfusion mode. In the perfusion mode, the rotating speed of the blood pump 330 changes in a sinusoidal manner, simulating the blood output mode of the heart beating. The controller 500 controls the opening degree of the first electric valve 3321 and the second electric valve 3411, so as to maintain the arterial pressure within a set range, and controls the flow of the second branch pipe 332 and the third branch pipe 341, so as to adjust the mixing ratio of the oxygenated blood and the non-oxygenated blood in the second blood supply vessel 311, thereby maintaining the blood oxygen saturation in the second blood supply vessel 311 between 60% and 75%.

[0068] In some embodiments, during the organ perfusion process, it is necessary to continuously supplement the nutrient consumption of the organ itself and prevent the occurrence of coagulation and inflammation, etc. Therefore, a first medicine feeder 370 is connected in the pipeline before the blood pump 330, the first medicine feeder 370 contains a first medicament for supplementing nutrient substances and antibiotics, etc., and can supplement the first medicament into the pipeline, so that the blood in the first blood supply vessel 310 and the second blood supply vessel 311 can be supplemented with nutrient substances and medicines. In the embodiment shown in FIG. 1, the first medicine feeder 370 is in communication with the blood filter 320, so as to inject the first medicament into the blood in the blood filter 320, and then deliver it to the portal vein and the artery through the blood pump 330. It should be noted that the first medicament can be one or a combination of heparin, insulin, glucose, antibiotics, etc. The first medicine feeder 370 can be one or can be provided with multiple ones for injecting different first medicaments.

[0069] In addition, if no intervention is made, the arterial flow resistance will gradually increase as the organ is kept out of the body for a longer time, and since the arterial perfusion pressure is kept within a set range, the arterial perfusion flow will gradually decrease. When the arterial perfusion flow is lower than the limit value, the arterial perfusion is insufficient, and a vasoactive drug needs to be injected into the artery to reduce the arterial flow resistance and increase the perfusion flow. Therefore, in the present application, the perfusion assembly 300 further comprises a second drug supplier 375 containing a second drug, which can be a vasoactive drug, for reducing the arterial flow resistance to increase the arterial perfusion flow. It should be noted that the second drug supplier 375 is in communication with the first blood supply vessel 310, and only needs to inject the second drug into the blood in the first blood supply vessel 310.

[0070] It should be noted that the first drug supplier 370 and the second drug supplier 375 are both automatic drug suppliers that can automatically inject drugs under the action of the controller 500 without manual injection. In some embodiments, the controller 500 detects the flow data of the first flow sensor 3101, and when the detected flow data is less than a first set value, the controller 500 controls the second drug supplier 375 to work to inject the second drug into the blood in the first blood supply vessel 310 to reduce the arterial impedance and increase the arterial flow.

[0071] In some embodiments, as shown in FIGS. 1, 3 and 4, the organ transfer machine of the present application also has two temperature control stages of heating and temperature maintaining. In the heating stage, the heating module 350 is used to heat the blood-oxygen mixing module 340, and the temperature of the heat exchange water in the blood-oxygen mixing module 340 is detected by the first temperature sensor 343 to prevent the temperature of the heat exchange water from being too high to damage the blood cells. The first temperature sensor 343 detects the blood temperature of the blood outlet pipe of the blood-oxygen mixing module 340, and this measured value is the perfusion temperature. The heating efficiency of the heating module 350 is controlled by using a PID algorithm (a PID control algorithm is a control algorithm that combines proportional, integral and differential three links) to make the temperature feedback by the first temperature sensor 343 within a first temperature range. After the perfusion temperature reaches the set range, the temperature maintaining stage is entered.

[0072] In the temperature maintaining stage, since the oxygen production module 360 uses a molecular sieve type oxygen production, the heat generated during the oxygen production process can be introduced into the functional cavity 110 through the heat dissipation air duct to heat the gas in the functional cavity 110, and the waste heat generated by the oxygen production module 360 is used to maintain the temperature of the functional cavity 110, so that each outlet pipe and supply pipe of the perfusion assembly 300 is within a set perfusion temperature range.

[0073] Specifically, as shown in FIG. 4, the oxygen production module 360 includes a first channel 361 in communication with the functional cavity 110, a second channel 362 in communication with the external environment, and a switching valve 363 disposed at the intersection of the first channel 361 and the second channel 362. It should be explained that the first channel 361 and the second channel 362 are both connected to the heat dissipation pipeline of the oxygen production module 360 for leading out the heat generated by the oxygen production module 360. The switching valve 363 is used to control the opening degree of the first channel 361 and the second channel 362, so that the temperature in the functional cavity 110 is also maintained within the first temperature range.

[0074] It can be understood that the opening degrees of the first channel 361 and the second channel 362 are negatively correlated, that is, when the opening degree of the first channel 361 increases, the hot air flow introduced into the functional cavity 110 increases, and the opening degree of the second channel 362 decreases, and the heat dissipated into the surrounding environment decreases, and vice versa. The switching valve 363 realizes the on-off control of the two heat dissipation channels, simplifies the number of electric control components, and saves the cost. Moreover, by utilizing the waste heat generated by the oxygen production module 360 for heat preservation, the energy utilization efficiency is improved, and the power consumption of the organ transport machine is reduced.

[0075] A second temperature sensor 111 is also disposed in the functional cavity 110 for measuring the gas temperature in the functional cavity 110. After the gas temperature in the functional cavity 110 reaches the set perfusion temperature, the hot air flow into the functional cavity 110 is controlled by the switching valve 363, so that the gas temperature of the switching valve 363 is maintained within the set perfusion temperature range.

[0076] In addition, as shown in FIG. 1, the organ transport machine also includes a display 550, which is in communication with the controller 500 and is used to display various parameters in the organ transport machine, including but not limited to perfusion flow, perfusion pressure, perfusion temperature, rotation speed of the blood pump 330, etc.

[0077] The above embodiments of the present application are described in detail in combination with the drawings, but the present application is not limited to the above embodiments, and various changes can be made within the knowledge range of ordinary skilled in the art without departing from the purpose of the present application. In addition, the embodiments of the present application and the features in the embodiments can be combined with each other without conflict.

Claims

1. An organ transport machine, characterized by, The organ transport machine comprises: a machine body defining a functional cavity; an organ container placed in the functional cavity, the organ container having a support for carrying an isolated organ; a perfusion assembly partially inserted into the organ container for connection with the isolated organ to circulate blood in the isolated organ; wherein the organ transport machine is further provided with a driving assembly arranged below the support to drive the support to reciprocally move the isolated organ in a vertical direction.

2. The organ transport machine of claim 1, wherein, The organ container comprises a first box and a second box which can be closed, the support is arranged in the first box, and a protection member made of flexible material is arranged in the organ container, the protection member can cover the isolated organ, so that the protection member and the support jointly define the displacement of the isolated organ.

3. The organ transport machine of claim 1, wherein, The support is made of flexible material, and when the support carries the isolated organ, the support is deformed to be concave downward. The driving assembly comprises a first air bag and a driving motor, the driving motor is used to drive the first air bag to reciprocally move in a vertical direction, when the first air bag abuts against the support and drives the support to move upward, the support gradually tends to be flat. Alternatively, the driving assembly comprises a first air bag and a gas pump, the gas pump is used to inflate or deflate the first air bag to increase or decrease the volume of the first air bag, when the volume of the first air bag increases until the first air bag abuts against the support and drives the support to move upward, the support gradually tends to be flat.

4. The organ transport machine of claim 1, wherein, The perfusion assembly comprises a first blood supply tube for connection with the artery of the isolated organ, a second blood supply tube for connection with the portal vein of the isolated organ, and a first blood discharge tube for connection with the inferior vena cava of the isolated organ, the perfusion assembly further comprises a blood filter and a blood pump, the first blood discharge tube is in communication with the blood filter, the first blood supply tube and the second blood supply tube are respectively in communication with the blood pump, and the blood pump is used to deliver the blood filtered by the blood filter back to the isolated organ.

5. The organ transport machine of claim 4, wherein, The perfusion assembly further comprises a blood oxygen mixing module, the blood pump has a first branch tube and a second branch tube, the first branch tube and the second branch tube are used to flow non-oxygenated blood, the first branch tube is in communication with the blood oxygen mixing module to convert the non-oxygenated blood into oxygenated blood, and the blood oxygen mixing module has a third branch tube and a fourth branch tube for flowing the oxygenated blood, the second branch tube and the third branch tube are both in communication with the second blood supply tube, and the fourth branch tube is in communication with the first blood supply tube.

6. The organ transport machine of claim 5, wherein, The second branch tube is provided with a first electric valve, the third branch tube is provided with a second electric valve, and the organ transport machine further comprises a controller which controls the opening degrees of the first electric valve and the second electric valve respectively to adjust the proportion of oxygenated blood and non-oxygenated blood in the second blood supply tube.

7. The organ transport machine of claim 6, wherein, The organ transport machine has a pre-perfusion mode and a perfusion mode, in the pre-perfusion mode, the controller controls the opening degrees of the first and second electric valves respectively to maintain the flow ratio of the first and second blood supply vessels between 1:3 and 1:4; in the perfusion mode, the controller controls the opening degrees of the first and second electric valves respectively to maintain the blood oxygen saturation in the second blood supply vessel between 60% and 75%.

8. The organ transport machine of claim 4, wherein, The perfusion assembly further comprises a first medicine feeder containing a first medicine, which is communicated with the blood filter to inject the first medicine into the blood in the blood filter. And / or, the perfusion assembly further comprises a second medicine feeder containing a second medicine, which is communicated with the first blood supply vessel to inject the second medicine into the blood in the first blood supply vessel.

9. The organ transport machine of claim 4, wherein, The organ transport machine further comprises a controller, the perfusion assembly comprises a second medicine feeder containing a second medicine, the second medicine feeder is communicated with the first blood supply vessel, the first blood supply vessel is provided with a first flow sensor for detecting the flow in the first blood supply vessel, when the flow data detected by the first flow sensor is less than a first set value, the controller controls the second medicine feeder to work to inject the second medicine into the blood in the first blood supply vessel.

10. The organ transport machine of claim 1, wherein, The perfusion assembly comprises a heating module and a blood oxygen mixing module, the heating module is used to supply heat to the blood oxygen mixing module to make the outlet liquid temperature of the blood oxygen mixing module within a first temperature range; The perfusion assembly further comprises an oxygen production module, the oxygen production module comprises a first channel communicated with the functional cavity, a second channel communicated with an external environment, and a switching valve arranged at the intersection of the first channel and the second channel, the first channel and the second channel are used to lead out the heat generated by the oxygen production module, the organ transport machine further comprises a controller, the switching valve is controlled by the controller to adjust the opening degrees of the first channel and the second channel to make the temperature in the functional cavity within a first temperature range.

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