Photon beam dose correction method and apparatus for lipiodol area, terminal device, and storage medium

Abstract

The present application relates to the technical field of correction methods, and in particular to a photon beam dose correction method and apparatus for a lipiodol area. The method comprises the following steps: S1, placing lipiodol samples of different component proportions in a simulation phantom; S2, using a radiotherapy planning system to respectively perform photon beam irradiation and simulation irradiation on the simulation phantom to respectively obtain and determine an actual photon beam dose and a simulated photon beam dose; S3, on the basis of corresponding actual photon beam doses and simulated photon beam doses under the lipiodol samples of different component proportions, obtaining a correction function for a photon beam dose; S4, on the basis of the component proportions of the lipiodol samples and the correction function, obtaining a correction factor for the photon beam dose, and determining a correction value for a required dose in the radiotherapy planning system. Therefore, the relative electron density of a lipiodol sample of a certain component proportion after photon beam irradiation can be obtained, thereby obtaining a corresponding correction factor for a photon beam dose by means of the relative electron density.

Description

Iodized oil region photon beam dose correction method, device, terminal equipment and storage medium

[0001] Cross-reference to Related Applications

[0002] The present application claims priority to the Chinese patent application No. 202410761690.6, filed on June 13, 2024, and entitled "Iodized oil region photon beam dose correction method", the entire content of which is incorporated herein by reference. TECHNICAL FIELD

[0003] The present application relates to the technical field of correction methods, in particular to an iodized oil region photon beam dose correction method. BACKGROUND

[0004] Iodized oil is needed in the process of photon beam test, which specifically deposits in cancer tissue and does not disappear during treatment. However, the presence of iodized oil will affect the actual test dose of photon beam, resulting in deviation between the actual test dose of photon beam and the test dose set by the radiotherapy planning system, and adversely affecting treatment.

[0005] The existing method is to adjust the set value by experience when medical staff sets the test dose of the radiotherapy planning system based on the actual required photon beam test dose. However, this method only adjusts by experience, which has certain contingency, and sometimes there is a large deviation between the actual test dose after adjustment and the actual required photon beam test dose.

[0006] SUMMARY

[0007] Therefore, the present application aims to overcome the technical problems in the prior art and provide a more scientific iodized oil region photon beam dose correction method obtained through experiments.

[0008] The present application provides an iodized oil region photon beam dose correction method, comprising:

[0009] S1, placing iodized oil samples with different component proportions in a simulation phantom;

[0010] S2, using a radiotherapy planning system, respectively irradiating the simulation phantom with a photon beam and simulating the irradiation to obtain a determined photon beam actual dose and a photon beam simulated dose;

[0011] S3, based on the corresponding photon beam actual dose and photon beam simulated dose under different component proportions of iodized oil samples, obtaining a photon beam dose correction function;

[0012] S4, obtaining a photon beam dose correction factor based on the component proportion of the iodized oil sample and a correction function, and determining a correction value of the required dose in the radiotherapy planning system.

[0013] Further, in the step S2, the irradiation dose of the photon beam irradiation and the simulation irradiation is the same.

[0014] Further, in the step S2, a CT image is obtained by CT scanning of the simulation phantom, and the radiotherapy planning system performs simulation irradiation on the CT image.

[0015] Further, the photon beam simulation dose is represented by the relative electron density on the CT image after simulation irradiation.

[0016] Further, the step S3 comprises:

[0017] S31, fitting a function of the relative electron density based on the component proportion of the iodized oil sample, and obtaining a fitting function of the relative electron density;

[0018] S32, calculating a deviation proportion of the photon beam actual dose and the photon beam simulation dose under different component proportions of the iodized oil sample;

[0019] S33, fitting a function of the obtained deviation proportions based on the relative electron densities corresponding to different component proportions of the iodized oil sample, and calibrating the function as a correction function.

[0020] Further, in the step S32, the deviation proportion is calculated by a deviation calculation formula, and the deviation calculation formula is as follows: δ=(D real -D TPS ) / D TPS *100%,

[0021] Wherein, δ is the deviation proportion, D real is the photon beam actual dose, and D TPS is the photon beam simulation dose.

[0022] Further, the step S4 comprises:

[0023] S41, obtaining the corresponding relative electron density by substituting the component proportion of the iodized oil sample into the fitting function of the relative electron density;

[0024] S42, obtaining the photon beam dose correction factor by substituting the obtained relative electron density into the correction function;

[0025] S43, calculating the correction value of the required dose in the radiotherapy planning system based on the required dose in the radiotherapy planning system and the correction factor, and the deviation calculation formula, wherein the correction factor is substituted into the deviation proportion, and the required dose is substituted into the photon beam actual dose.

[0026] An iodized oil region photon beam dose correction device, comprising:

[0027] A test module for placing iodized oil samples with different ingredient proportions in a simulation phantom;

[0028] An irradiation module for using a radiotherapy planning system to respectively irradiate the simulation phantom with a photon beam and simulate irradiation, and respectively obtain a photon beam actual dose and a photon beam simulated dose;

[0029] A calculation module for obtaining a correction function of the photon beam dose based on the corresponding photon beam actual dose and the photon beam simulated dose under the iodized oil samples with different ingredient proportions;

[0030] A correction module for obtaining a photon beam dose correction factor based on the ingredient proportion of the iodized oil sample and the correction function, and determining a correction value of a required dose in the radiotherapy planning system.

[0031] A terminal device comprising a memory and a processor, the memory storing a computer program executable on the processor, and the processor implements the iodized oil region photon beam dose correction method as described above when executing the computer program.

[0032] A computer readable storage medium storing a computer program, the computer program being executed by a processor to implement the iodized oil region photon beam dose correction method as described above.

[0033] The technical solution of the present application has the following advantages:

[0034] The iodized oil region photon beam dose correction method provided by the present application establishes a functional relationship between the photon beam actual dose and the photon beam simulated dose, and then obtains a photon beam dose correction factor to obtain a correction value of a required dose. It has relatively high scientificity and accuracy.

[0035] The iodized oil region photon beam dose correction method provided by the present application can obtain the relative electron density of an iodized oil sample with a certain ingredient proportion after being irradiated by a photon beam, and then obtain the corresponding photon beam dose correction factor through the relative electron density. When estimating, based on the formula δ = (D real -D TPS ) / D TPS *100%, the photon beam dose correction factor δ can be determined through the above, and the actual required photon beam test dose is D real , and D TPS can be calculated. The present application obtains the relationship between the ingredient proportion of the iodized oil sample and the corresponding relative electron density through the test method, and the relationship between the relative electron density and the corresponding photon beam dose correction factor, which has relatively high scientificity and accuracy. BRIEF DESCRIPTION OF DRAWINGS

[0036] In order to more clearly illustrate the technical solutions of the embodiments of the present application or the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly introduced. Obviously, the drawings in the following description are some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative labor.

[0037] Fig. 1 is a schematic diagram of the principle of the present application;

[0038] Fig. 2 is a schematic diagram of the principle of the present application;

[0039] Fig. 3 is a schematic diagram of the principle of the present application;

[0040] Fig. 4 is a schematic diagram of the preparation of iodine oil samples and a simulation phantom of the present application;

[0041] Fig. 5 is a CT scan coronal view of an abdominal simulation phantom after inserting a sample tube of the present application;

[0042] Fig. 6 is a RED calibration fitting curve diagram of iodine oil samples with different mixing ratios of the present application;

[0043] Fig. 7 is a fitting curve diagram of different RED and photon beam dose correction factors δ of the present application;

[0044] Fig. 8 is a structural block diagram of a photon beam dose correction device in the iodine oil region of the present application;

[0045] Fig. 9 is a schematic diagram of the hardware structure of a terminal device of the present application. DETAILED DESCRIPTION

[0046] The technical solutions of the present application will be described in detail below with reference to the drawings. Obviously, the described embodiments are some embodiments of the present application, not all embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor are within the scope of protection of the present application.

[0047] In the description of the present application, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer" and the like indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as limiting the present application. In addition, the terms "first", "second", "third" are only for descriptive purposes and cannot be understood as indicating or implying relative importance.

[0048] In the description of the present application, it should be noted that unless specifically defined and limited otherwise, the terms "mounting", "connected", "connection" should be understood broadly, for example, can be fixedly connected, can be detachably connected, or integrally connected; can be mechanically connected, can be electrically connected; can be directly connected, can be indirectly connected through an intermediate medium, and can be internal communication of two elements. For those skilled in the art, the specific meanings of the above terms in the present application can be understood according to the specific circumstances.

[0049] In addition, the technical features involved in the different embodiments of the present application described below can be combined with each other as long as there is no conflict.

[0050] Embodiment

[0051] This embodiment takes liver cancer as an example. Liver cancer is the sixth most common malignant tumor and the third leading cause of cancer-related death worldwide, causing 830,000 deaths each year. In China, liver cancer has the fourth highest incidence and the second highest mortality rate. Hepatocellular carcinoma is the most common histological type of primary liver cancer, accounting for 75%-85% (1). Liver cancer is insidious in onset. In China, 64% of patients are in the middle and advanced stages at the time of initial diagnosis. Transcatheter arterial chemoembolization (TACE) is an important treatment method. For BCLC B stage, good liver function, and no macrovascular invasion or extrahepatic spread of hepatocellular carcinoma patients, TACE is currently considered a first-line treatment method. However, TACE is not a radical treatment for most patients. Combination therapy of TACE can significantly improve patient outcomes. Meta-analysis shows that interventional combination therapy significantly improves objective response rate (ORR) compared to simple intervention, and median survival is extended from 13.5 months to 22.7 months.

[0052] Iodized oil is specifically deposited in hepatocellular carcinoma tissue after interventional therapy and does not disappear during treatment, resulting in an increase in the Hounsfield unit (HU) of the tumor area in CT images. In photon radiotherapy, the radiotherapy planning system (TPS) converts the HU value of the CT image into relative electron density (RED) to calculate the dose distribution, so the increase in the HU value of the iodized oil area will change the RED, resulting in a change in the dose distribution. DONGHO SHIN et al. evaluated the effect of iodized oil on the depth of the proton test beam and found that the high HU value of the iodized oil area would result in a deeper actual beam depth for proton therapy, and the TPS would overestimate the blocking power of iodized oil for the proton beam, resulting in a significant difference between the actual dose delivered to the tumor area and the organ at risk (OAR) and the planned dose. After measuring the iodine-containing liquid marker used in lung proton radiotherapy by Scherman et al., it was found that the iodized oil marker could cause a 4.8% dose disturbance. In photon radiotherapy, whether the TPS directly calculates the photon dose according to the converted RED is accurate, and the dosimetric effect of the iodized oil deposition area on the photon beam needs further study. The direct use of pure iodized oil in previous studies is necessary to design a system for simulating different density iodized oil areas after liver tumor intervention for clinical research. Based on the dosimetric effect of the iodized oil deposition area on the photon beam, the photon beam test dose can be estimated when setting the radiotherapy planning system.

[0053] An iodized oil area photon beam dose correction method as shown in FIGS. 1 to 7, comprising:

[0054] S1, placing iodized oil samples with different component proportions in a simulation phantom;

[0055] S2, using a radiotherapy planning system, respectively irradiating and simulating the simulation phantom with a photon beam to obtain the actual dose of the photon beam and the simulated dose of the photon beam;

[0056] S3, based on the corresponding actual dose of the photon beam and the simulated dose of the photon beam under different component proportions of the iodized oil sample, obtaining a correction function of the photon beam dose;

[0057] S4, based on the component proportion of the iodized oil sample and the correction function, obtaining a photon beam dose correction factor to determine the correction value of the required dose in the radiotherapy planning system.

[0058] In the step S1, the iodized oil sample can be made by mixing iodized oil and ground pork liver. Specifically, uniform ground pork liver and iodized oil injection can be used to mix the iodized oil sample in six different proportions, with a mixing ratio of 0ml / 100g, 2ml / 100g, 5ml / 100g, 10ml / 100g, 15ml / 100g, and 20ml / 100g.

[0059] The iodine oil samples with different component proportions can be arranged in corresponding sample bins, and the sample bins containing the iodine oil samples are inserted into the simulation phantom. The simulation phantom can be an abdominal simulation phantom. CT scanning of the simulation phantom is performed by using a CT scanner, and a CT image is obtained.

[0060] The two adjacent sample bins are detachably connected, and the plurality of sample bins are sequentially connected to form a sample tube. The capacity of each sample bin can be about 60 ml.

[0061] The ionization chamber channel is arranged in the middle position of the sample tube. CT scanning and dose measurement can be conveniently performed. The material of the sample bin is PE material, and the sample bins are sealingly connected in the sample tube.

[0062] Further, in the step S2, the irradiation dose of the photon beam irradiation and the simulation irradiation is the same.

[0063] Further, in the step S2, the CT image is obtained by performing CT scanning on the simulation phantom, and the radiotherapy planning system performs simulation irradiation on the CT image.

[0064] Further, the photon beam simulation dose is represented by the relative electron density on the CT image after simulation irradiation.

[0065] Further, the step S3 comprises:

[0066] S31, based on the component proportion of the iodine oil sample, a function fitting is performed on the corresponding relative electron density to obtain a fitting function of the relative electron density;

[0067] S32, the deviation proportion of the photon beam actual dose and the photon beam simulation dose under different component proportions of the iodine oil sample is calculated;

[0068] S33, based on the corresponding relative electron density of the iodine oil sample with different component proportions, a function fitting is performed on the obtained each deviation proportion to calibrate a correction function.

[0069] Further, in the step S32, the deviation proportion is calculated by using a deviation calculation formula, and the deviation calculation formula is as follows:

[0070] δ=(D real -D TPS ) / D TPS *100%,

[0071] Wherein, δ is the deviation proportion, D real is the photon beam actual dose, and D TPS is the photon beam simulation dose.

[0072] Further, the step S4 comprises:

[0073] S41, based on the proportion of the iodized oil sample, the fitting function of the relative electron density is substituted to obtain the corresponding relative electron density;

[0074] S42, the obtained relative electron density is substituted into the correction function to obtain the photon beam dose correction factor;

[0075] S43, based on the required dose in the radiotherapy planning system and the correction factor, and the deviation calculation formula, the correction value of the required dose in the radiotherapy planning system is calculated, wherein the correction factor is substituted into the deviation ratio, and the required dose is substituted into the actual dose of the photon beam.

[0076] Specifically, the CT image is imported into the radiotherapy planning system, the radiotherapy planning system performs photon beam simulation irradiation on the imported CT image to obtain a photon beam simulation dose. The iodized oil area, ionization chamber detector and normal tissue organ (OAR) are respectively outlined on the CT images of iodized oil samples with different mixing proportions. In this embodiment, fixed 6MV X-ray, different segmentation modes (1Gy / f-10Gy / f) and uniform block modes (FF / FFF) can be used in the radiotherapy planning system to simulate irradiation of iodized oil areas with different densities in sequence, and the photon beam simulation dose D TPS of the current radiotherapy planning system is recorded, wherein the photon beam simulation dose is the Hu value on the CT image, and the radiotherapy planning system can calculate the photon beam simulation dose D TPS of the current radiotherapy planning system through the HU-RED conversion relationship. It should be noted that the radiotherapy planning system performs photon beam simulation irradiation on the imported CT image, and multiple simulation irradiations will not affect the CT image, meeting the requirement of controlling variables.

[0077] In this embodiment, in order to avoid the difference in HU value definition of different CT scanners and radiotherapy planning systems, the electronic density of the iodized oil sample with different mixing proportions is accurately calibrated. This calibration density will be used as a standard reference for subsequent research. The sample bin containing the iodized oil sample is assembled every three groups and inserted into the base of the abdominal simulation phantom; the ionization chamber detector is placed at the center of each of the six sample bins, and the spiral CT scanning (Siemens SOMATOM Definition AS CT) is performed at 1mm per layer, the scanning voltage is 120kV, and the current is 300mA. The scanned image (Figure 5) is uploaded to the radiotherapy planning system (Pinnacle3 V16.2) used by the unit, and the RED of the iodized oil sample with different mixing proportions in each group is calibrated based on the HU-RED conversion relationship used by the radiotherapy planning system, wherein the RED is the relative electron density in this application.

[0078] Figure 4 is the preparation and simulation phantom of iodine oil samples, wherein A is 100g of uniform chopped pig liver equivalent to human liver tissue; B is 2ml, 5ml, 10ml, 15ml and 20ml of Libo Duo iodine oil injection; C is the mixed proportion of 0ml / 100g, 2ml / 100g, 5ml / 100g, 10ml / 100g, 15ml / 100g and 20ml / 100g of iodine oil samples after being filled into the sample tube, and each three groups are assembled; D is a design drawing of the cylindrical sample tube which can be assembled, and an ionization chamber channel is reserved in the middle; E is a physical drawing of the sample tube which is not assembled; F is a schematic diagram of an abdominal simulation phantom; and G is a physical drawing of the abdominal simulation phantom after the sample tube is inserted.

[0079] Figure 5 is a CT scan coronal view of the abdominal simulation phantom after the sample tube is inserted: A shows from bottom to top 0ml / 100g, 2ml / 100g and 5ml / 100g of iodine oil samples, and at this time the ionization chamber detector is located at the center of the 2ml / 100g sample tube; B shows from bottom to top 10ml / 100g, 15ml / 100g and 20ml / 100g of iodine oil samples, and at this time the ionization chamber detector is located at the center of the 15ml / 100g sample tube.

[0080] Further, the ionization chamber detector is inserted into the ionization chamber channel to obtain the actual dose of the relative electron density.

[0081] Wherein, the abdominal simulation phantom with the sample tube inserted is irradiated by the same beam as the TPS using a linear accelerator, the ionization chamber charge number at the center of each sample bin is read by the ionization chamber detector, the relative electron density under each mode is recorded, and the actual dose D of the photon beam is obtained through the HU-RED conversion relationship real . The D TPS and D real under each mode are compared to obtain the relationship between the photon beam dose correction factor δ and the iodine oil deposition area RED, wherein the photon beam dose correction factor δ is calculated according to the following formula:

[0082] δ=(D real -D TPS ) / D TPS *100%.

[0083] Under different segmentation modes (1Gy / f-10Gy / f) and uniform block modes (FF / FFF), the relationship between the photon beam dose correction factor δ and the iodine oil area RED is obtained. The calibration fitting curve of the RED of the iodine oil sample with different mixing proportions is shown in Figure 6 (R2=0.9994). Among them, the RED of the 0ml / 100g sample without mixed iodine oil is 1.062g / cm3, which is close to the RED of the normal human liver tissue (1.05-1.07g / cm3) (14), indicating that the method of the embodiment conforms to the actual situation.

[0084] Figure 6 shows the RED calibration fitting curves for iodized oil samples with different mixing ratios. The linearity of the calibration curves is R2 = 0.9994. The other density values ​​were calculated using linear interpolation.

[0085] Under different partitioning modes (1Gy / f–10Gy / f) and uniform block mode (FF / FFF), the iodized oil region D of different REDs TPS and D real The photon beam dose correction factor δ is shown in Figure 7. For the 0 ml / 100 g sample without iodized oil, the photon beam dose correction factor δ is close to 0 (μ±σ=0.06%±0.04%, μ is the mean, σ is the standard deviation), which verifies the accuracy of the TPS calculation results and the actual measurement results without considering the influence of the iodized oil region. Under fixed segmentation and uniform block modes, the δ value gradually increases with increasing iodized oil content (range: 0.54% to 5.74%, P<0.0001), indicating that TPS underestimates the dose calculation results of the iodized oil region in photon radiotherapy.

[0086] Figure 7 shows the fitting curves of different RED values ​​and photon beam dose correction factors δ under different fractionation modes (1 Gy / f–10 Gy / f) and uniform block modes (FF / FFF). The average linearity R² = 0.9985 in FF mode and 0.9975 in FFF mode. Other photon beam dose correction factors δ were calculated using linear interpolation. Figure 7 shows that under fixed fractionation and uniform block modes, the δ value gradually increases with increasing iodized oil content (range: 0.54%–5.74%, P<0.0001), indicating that the radiotherapy planning system underestimates the dose calculation results in the iodized oil region. Under the same fractionation mode, the correction factor δFFF in FFF mode is systematically higher than that in FF mode (δFF ranges from 0.27% to 4.31%, δFFF ranges from 0.54% to 5.74%, P<0.0001). This can be explained by the formula δ = (D real -D TPS ) / D TPS *100%, the actual required photon beam test dose is D. real Make corrections.

[0087] The above experiments allow us to obtain the relative electron density of an iodine oil sample with a specific composition ratio after photon beam irradiation. This relative electron density can then be used to obtain the corresponding photon beam dose correction factor. When estimating, the formula δ=(D real -D TPS ) / D TPS *100%, the photon beam dose correction factor δ can be determined through the above, and the actual required photon beam test dose is D.real , D can be calculated TPS Since the method is used to obtain the relationship between the iodine oil sample component ratio and the corresponding relative electron density by function fitting, and the relationship between the relative electron density and the corresponding photon beam dose correction factor is obtained by function fitting.

[0088] An iodine oil region photon beam dose correction device, comprising:

[0089] A test module is configured to place iodine oil samples with different component ratios in a simulation phantom;

[0090] An irradiation module is configured to use a radiotherapy planning system to respectively irradiate the simulation phantom with a photon beam and simulate the irradiation, and respectively obtain a photon beam actual dose and a photon beam simulated dose;

[0091] A calculation module is configured to obtain a photon beam dose correction function based on the corresponding photon beam actual dose and the photon beam simulated dose under different component ratios of the iodine oil sample;

[0092] A correction module is configured to obtain a photon beam dose correction factor based on the component ratio of the iodine oil sample and the correction function, and determine a correction value of a required dose in the radiotherapy planning system.

[0093] A terminal device, comprising a memory and a processor, the memory stores a computer program capable of running on the processor, and the processor implements the above-mentioned iodine oil region photon beam dose correction method when executing the computer program.

[0094] A computer readable storage medium, the computer readable storage medium stores a computer program, and the computer program is executed by a processor to implement the above-mentioned iodine oil region photon beam dose correction method.

[0095] Obviously, the above-mentioned embodiments are only examples for clearly illustrating, and not limited to the embodiments. For those skilled in the art, other different forms of changes or variations can be made on the basis of the above-mentioned description. Here, all the embodiments need not and cannot be exhausted. The obvious changes or variations derived therefrom are still within the protection scope of the present application.

Claims

1. A method for iodine oil region photon beam dose correction, characterized by, The method comprises the following steps: S1, placing iodine oil samples with different component proportions in a simulation phantom; S2, using a radiotherapy planning system to perform photon beam irradiation and simulation irradiation on the simulation phantom respectively to obtain actual photon beam dose and simulated photon beam dose respectively; S3, obtaining a correction function of photon beam dose based on the corresponding actual photon beam dose and simulated photon beam dose under the iodine oil samples with different component proportions; S4, obtaining a photon beam dose correction factor based on the component proportion of the iodine oil sample and the correction function, and determining a correction value of the required dose in the radiotherapy planning system.

2. The iodized oil region photon beam dose correction method of claim 1, wherein, In the step S2, the irradiation dose of the photon beam irradiation and the simulation irradiation is the same.

3. The iodized oil region photon beam dose correction method of claim 1, wherein, In the step S2, a CT image is obtained by performing CT scanning on the simulation phantom, and the radiotherapy planning system performs simulation irradiation on the CT image.

4. The iodized oil region photon beam dose correction method of claim 3, wherein, The simulated photon beam dose is represented by the relative electron density on the CT image after simulation irradiation.

5. The iodized oil region photon beam dose correction method of claim 4, wherein, The step S3 comprises: S31, fitting a function based on the component proportion of the iodine oil sample and the corresponding relative electron density, obtaining a fitting function of the relative electron density; S32, calculating the deviation proportion of the actual photon beam dose and the simulated photon beam dose under the iodine oil samples with different component proportions; S33, fitting a function based on the corresponding relative electron density of the iodine oil samples with different component proportions, and calibrating the obtained deviation proportions as the correction function.

6. The iodized oil region photon beam dose correction method of claim 5, wherein, In the step S32, the deviation ratio is calculated by a deviation calculation formula as follows: δ = (D real -D TPS ) / D TPS * 100%, where δ is the deviation ratio, D real is the actual dose of the photon beam, D TPS is the simulated dose of the photon beam.

7. The iodized oil region photon beam dose correction method of claim 6, wherein, The step S4 comprises: S41, obtaining the corresponding relative electron density by substituting the component proportion of the iodine oil sample into the fitting function of the relative electron density; S42, obtaining the photon beam dose correction factor by substituting the obtained relative electron density into the correction function; S43, calculating the correction value of the required dose in the radiotherapy planning system based on the required dose in the radiotherapy planning system and the correction factor, and a deviation calculation formula, wherein the correction factor is substituted into the deviation proportion, and the required dose is substituted into the actual photon beam dose.

8. An iodine oil region photon beam dose correction device, characterized by, The method comprises the following steps: A test module for placing iodine oil samples with different component proportions in a simulation phantom; An irradiation module for using a radiotherapy planning system to perform photon beam irradiation and simulation irradiation on the simulation phantom respectively to obtain actual photon beam dose and simulated photon beam dose respectively; A calculation module for obtaining a correction function of photon beam dose based on the corresponding actual photon beam dose and simulated photon beam dose under the iodine oil samples with different component proportions; A correction module for obtaining a photon beam dose correction factor based on the component proportion of the iodine oil sample and the correction function, and determining a correction value of the required dose in the radiotherapy planning system. 9.A terminal device, comprising a memory and a processor, wherein the memory stores a computer program capable of running on the processor, and the computer program comprises the following steps of: The processor executes the computer program to realize the iodine oil region photon beam dose correction method in any one of claims 1 to 7.

10. A computer-readable storage medium storing a computer program, the computer program comprising instructions that, when executed by a computer, cause the computer to perform the method of any one of claims 1 to 9. The computer program is executed by the processor to realize the iodine oil region photon beam dose correction method in any one of claims 1 to 7.

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