Peptide having CGRP mimotope function and CGRP detection using same
A single-step immunoassay using mimotopes addresses the time-consuming and degradation issues of CGRP detection, enabling rapid and accurate quantification of CGRP for migraine diagnosis.
WO2025258888A1 Publication Date: 2025-12-18UI (UNIVERSITY IND FOUNDATION) YONSEI UNIVERSITY
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Patent Information
- Application Number
- PCT/KR2025/007132
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2025-05-13
- Filing Date
- 2025-05-27
- Publication Date
- 2025-12-18
AI Technical Summary
Technical Problem
Existing CGRP detection methods are time-consuming and suffer from rapid degradation of CGRP by proteolytic enzymes, necessitating a rapid and accurate detection method for migraine diagnosis.
Method used
Development of a single-step immunoassay using chemically mimicked peptides (mimotopes) that bind to CGRP, allowing for rapid and accurate quantification within 30 minutes, utilizing an Fv-antibody library expressed on E. coli and pre-conjugated with fluorescently labeled antibodies.
Benefits of technology
The method achieves statistically similar results to conventional ELISA within a shorter time frame, providing high sensitivity and specificity for CGRP detection, supporting early diagnosis and effective treatment of migraine.
✦ Generated by Eureka AI based on patent content.
Abstract
Disclosed are a peptide having CGRP mimotope function and CGRP detection using same. The peptide may have the following sequences: DVGSYTKAPDF, YGPGGSQAVDF, CRARAGIGLDF, and YVAKATGPADF. The peptide of the present invention can be used in a rapid and accurate single-step immunoassay for CGRP detection, and thus can be effectively used for diagnosis and treatment monitoring of migraine patients.
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