Tube reactor module, use of tube reactor module, and incubation device

The tube reactor module addresses the challenge of irregular liquid piping and prolonged processing times by employing a serpentine flow path with alternating curve sections and varying cross-sections, enhancing mixing and controlling residence time for efficient viral inactivation.

WO2026002887A1 Publication Date: 2026-01-02SARTORIUS STEDIM BIOTECH GMBH
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Patent Information

Application Number
PCT/EP2025/067574
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-06-25
Filing Date
2025-06-23
Publication Date
2026-01-02

AI Technical Summary

Technical Problem

Existing reactors face challenges in accurately measuring device volume, leading to irregular piping of process liquids, high residence time distribution, and insufficient processing quality due to prolonged processing times, which can degrade the process liquid, especially in applications like viral inactivation where precise control of mixing and residence time is crucial.

Method used

A tube reactor module with a tubular flow path featuring a serpentine pattern of alternatingly bent curve sections, changing the flow direction by at least 90°, and varying cross-sections to enhance mixing and control residence time, utilizing a serpentine pattern with alternating curve sections and varying cross-sections to improve mixing and reduce residence time distribution.

Benefits of technology

The tube reactor module achieves effective mixing with reduced residence time distribution, ensuring efficient processing without excessive degradation, particularly beneficial for viral inactivation by maintaining a low residence time and minimizing exposure to harsh conditions.

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Abstract

The application relates to a tube reactor module for controlling a reaction time of a process fluid in dynamic operation, in particular during viral inactivation in the process fluid, comprising: an inlet for receiving the process fluid; an outlet for discharging the process fluid; a tubular flow path comprising a serpentine pattern for guiding the process fluid from the inlet to the outlet, the tubular flow path comprising a sequence of fluidly connected alternatingly bent curve sections, wherein each curve section is shaped such that a flow direction of the process fluid changes by at least approximately 90°, in particular by between approximately 135° and 225°, and wherein the tubular flow path comprises a first cross-section perpendicular to the flow direction of the process fluid at respective apexes of the curve sections and a second cross-section perpendicular to the flow direction of the process fluid at respective end portions of the curve sections, wherein the first cross-section is different from the second cross-section.
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