Mosquito repellent composition and preparation method therefor and use thereof, and product having composition

Abstract

A mosquito repellent composition and a preparation method therefor and a use thereof, and a product having the composition, relating to the technical field of mosquito repelling. The mosquito repellent composition comprises in percentage by weight: 0.1-40% of a mosquito repellent active ingredient, 1-10% of an emulsifier, 3-8% of an antifreeze agent, 0.1-3% of a thickener, 0.1-2% of a defoamer, and the balance being water, or 0.1-40% of a mosquito repellent active ingredient, 1-10% of an emulsifier, 1-10% of a capsule wall material, 0.1-0.5% of a pH regulator, 3-8% of an antifreeze agent, 0.1-3% of a thickener, 0.1-2% of a defoamer, and the balance being water, wherein the mosquito repellent active ingredient comprises α-ethylidene-phenylacetaldehyde, or a tautomer or cis-trans isomer thereof. Compared with an α-ethylidene-phenylacetaldehyde technical material, the mosquito repellent composition has greatly improved thermal storage stability and a longer-lasting mosquito repellent effect. Compared with emulsions in water and capsule suspensions prepared by other formulas, the emulsion stability after thermal storage is greatly improved.

Description

Mosquito repellent composition and its preparation method, application and product

[0001] Related applications

[0002] This application is a PCT application based on and claiming priority to Chinese patent application No. 2024110213188 filed on July 26, 2024. The patent application is incorporated herein in its entirety as if fully set forth. TECHNICAL FIELD

[0003] The present application belongs to the technical field of mosquito repellent, and specifically relates to a mosquito repellent composition and its preparation method, application and product. BACKGROUND

[0004] In addition to directly stinging and sucking blood, disturbing the peaceful working and living atmosphere, mosquitoes also spread a variety of serious diseases such as malaria, dengue fever (or dengue hemorrhagic fever), epidemic encephalitis B, lymphatic filariasis, yellow fever, and equine encephalitis, which seriously endanger human health.

[0005] Alpha-ethylidene-acetophenone, also known as 2-phenyl-2-butenal, is a synthetic food flavor. CN116868998A first discloses the mosquito repellent use of alpha-ethylidene-acetophenone. The invention finds that alpha-ethylidene-acetophenone has a significant mosquito repellent effect. By placing alpha-ethylidene-acetophenone around the environment or applying alpha-ethylidene-acetophenone as a potent mosquito repellent, mosquito bites can be prevented.

[0006] However, alpha-ethylidene-acetophenone exposed to the natural environment is easily lost through evaporation or degradation, so its mosquito repellent effect cannot be maintained for a long time. In particular, enal compounds are not stable enough. When exposed to the outdoors, alpha-ethylidene-acetophenone loses its function in a short time due to environmental factors such as ultraviolet light and heat.

[0007] Therefore, there is an urgent need for an alpha-ethylidene-acetophenone composition with good stability and more stable mosquito repellent effect.

[0008] SUMMARY

[0009] The present application provides a mosquito repellent composition and its preparation method, application and product to solve the problems in the prior art.

[0010] To achieve the above-mentioned purpose, the technical solutions adopted by the present application are as follows:

[0011] In a first aspect, the present application provides a method for improving the thermal storage stability of alpha-ethylidene-acetophenone, comprising the following steps:

[0012] Adjusting the content of alpha-ethylidene-acetophenone to 0.1-40wt%;

[0013] adjusting the content of the emulsifier to be 1-10 wt%;

[0014] adjusting the content of the antifreeze to be 3-8 wt%;

[0015] adjusting the content of the thickening agent to be 0.1-3 wt%;

[0016] adjusting the content of the antifoaming agent to be 0.1-2 wt%;

[0017] adjusting the balance to be water; or

[0018] adjusting the content of the α-ethylidene-benzaldehyde to be 0.1-40 wt%;

[0019] adjusting the content of the emulsifier to be 1-10 wt%;

[0020] adjusting the content of the capsule wall material to be 1-10 wt%;

[0021] adjusting the content of the pH adjuster to be 0.1-0.5 wt%;

[0022] adjusting the content of the antifreeze to be 3-8 wt%;

[0023] adjusting the content of the thickening agent to be 0.1-3 wt%;

[0024] adjusting the content of the antifoaming agent to be 0.1-2 wt%;

[0025] adjusting the balance to be water.

[0026] In some embodiments, the HLB of the emulsifier ranges from 12 to 16.

[0027] In some embodiments, the emulsifier is an anionic surfactant and / or a non-ionic surfactant.

[0028] In some embodiments, the emulsifier is at least one of a polyethylene glycol ether of a straight-chain alcohol, an ethoxylated nonyl phenol, a naphthalene sulfonate, a long-chain alkyl benzene sulfonate, and a block copolymer of propylene oxide and ethylene oxide.

[0029] The capsule wall material in the present invention is a polyurea, a polyurethane, or a polyamide, and the capsule wall material includes a first capsule wall material and a second capsule wall material.

[0030] In some embodiments, when the capsule wall material is a polyurea, the first capsule wall material is a diisocyanate and / or a polyisocyanate, and the second capsule wall material is at least one of ethylenediamine, diethylenetriamine, and triethylenetetramine.

[0031] In some embodiments, when the capsule wall material is polyurethane, the first capsule wall material is diisocyanate and / or polyisocyanate, and the second capsule wall material is at least one of ethylene glycol, propylene glycol, 1,4-butanediol, and 1,6-hexanediol.

[0032] In some embodiments, when the capsule wall material is polyamide, the first capsule wall material is terephthaloyl chloride, and the second capsule wall material is at least one of ethylenediamine, diethylenetriamine, and triethylenetetramine.

[0033] The antifreeze agent in the present application is at least one of ethylene glycol, propylene glycol, glycerol, and urea.

[0034] The thickening agent in the present application is at least one of xanthan gum, polyethylene glycol, polyvinyl alcohol, magnesium aluminum silicate, carboxymethyl cellulose, bentonite, white carbon black, polyvinylpyrrolidone, and acrylic acid dispersion.

[0035] The antifoaming agent in the present application is polydimethylsiloxane and / or polyether-modified silicone.

[0036] In a second aspect, the present application provides an anti-mosquito composition comprising, by weight percentage, 0.1-40% of an anti-mosquito effective ingredient, 1-10% of an emulsifier, 3-8% of an antifreeze agent, 0.1-3% of a thickening agent, 0.1-2% of an antifoaming agent, and the balance of water; or

[0037] In a second aspect, the present application provides an anti-mosquito composition comprising, by weight percentage, 0.1-40% of an anti-mosquito effective ingredient, 1-10% of an emulsifier, 3-8% of an antifreeze agent, 0.1-3% of a thickening agent, 0.1-2% of an antifoaming agent, and the balance of water; or

[0038] In some embodiments, the anti-mosquito effective ingredient is alpha-ethylidene-acetophenone.

[0039] In some embodiments, the anti-mosquito effective ingredient is alpha-ethylidene-acetophenone and a second anti-mosquito ingredient.

[0040] In some embodiments, the second anti-mosquito ingredient comprises a chemical synthetic mosquito repellent or a plant mosquito repellent.

[0041] Preferably, the chemical synthetic mosquito repellent comprises at least one of pyrethroid insecticide, organophosphorus insecticide, neonicotinoid insecticide, carbamate insecticide, bisamide insecticide, isoxazoline insecticide, DEET, diethyltoluamide, diethylmethylcuetpiperidinyl butylcarbinol, and icaridind.

[0042] The plant mosquito repellent is from a plant extract, preferably at least one of citronella, peppermint oil, Siberian fir, d-limonene, cedar, eucalyptus, peppermint, lemon grass, wormwood, tea tree, and geranium.

[0043] In some embodiments, the mass ratio of the alpha-ethylidene-substituted benzaldehyde and the second mosquito-repelling ingredient is 0.01-100:0-99.99.

[0044] In some embodiments, the mosquito-repelling composition is an emulsion in water or a microcapsule suspension.

[0045] In a third aspect, the present application provides a preparation method of the mosquito-repelling composition described above, comprising the following steps:

[0046] The mosquito-repelling effective ingredient is used as the oil phase, water and the emulsifier are used as the water phase, the oil phase is added to the water phase under shearing to form an oil-in-water emulsion, and finally other components are added and uniformly mixed to form an emulsion in water; or

[0047] The mosquito-repelling effective ingredient and the first capsule wall material are used as the oil phase, water and the emulsifier are used as the water phase, the oil phase is added to the water phase under shearing to form an oil-in-water emulsion, the second capsule wall material is added dropwise, and solidification is performed to form microcapsules, and finally other components are added and uniformly mixed to form a microcapsule suspension.

[0048] In some embodiments, the mass ratio of the first capsule wall material and the second capsule wall material is 3-12:1; preferably 5-10:1; and more preferably 6-9:1.

[0049] In some embodiments, the solidification is performed at a temperature of 30-60℃ for 1-3h.

[0050] In a fourth aspect, the present application provides a mosquito-repelling product comprising the mosquito-repelling composition described above or prepared by the preparation method described above.

[0051] The mosquito-repelling product described in the present application can achieve mosquito-repelling by being directly applied to the skin; can achieve mosquito-repelling by spatial repellent means, such as hanging, placing, carrying or pasting; and can also achieve mosquito-repelling by wearing mosquito-repelling clothing.

[0052] In a fifth aspect, the present application provides a mosquito-repelling method, which utilizes the volatilization of the mosquito-repelling composition described above or prepared by the preparation method described above or the mosquito-repelling product described above to achieve mosquito-repelling.

[0053] In some embodiments, the mosquito-repelling method comprises the following steps: loading the mosquito-repelling composition described above onto a carrier, drying the surface moisture to obtain a mosquito-repelling carrier; and placing the obtained mosquito-repelling carrier in a mosquito-repelling target area to achieve mosquito-repelling by volatilization of the effective ingredient.

[0054] In some embodiments, the carrier is selected from at least one of polyester, PE, non-woven fabric, cotton cloth, blended fabric, cotton fiber, nylon, synthetic fiber, gel, porous material and filter paper.

[0055] The alpha-ethylidene-acetophenone in the present application includes its tautomers or its cis-trans isomers.

[0056] Compared with the prior art, the present application has the following beneficial effects:

[0057] (1) The present application greatly improves the heat storage stability of the product by preparing alpha-ethylidene-acetophenone into water emulsion or microcapsule suspension, compared with single alpha-ethylidene-acetophenone original drug.

[0058] (2) The present application greatly improves the emulsion stability of the product after heat storage by preparing water emulsion or microcapsule suspension using emulsifiers with HLB value of 12-16, compared with preparations prepared using other emulsifiers not within this HLB range.

[0059] (3) The present application has more persistent mosquito repellent effect by preparing alpha-ethylidene-acetophenone into microcapsule suspension, compared with single alpha-ethylidene-acetophenone original drug or water emulsion.

[0060] (4) The alpha-ethylidene-acetophenone of the present application can be compounded with a second mosquito repellent component to play a synergistic effect, and has stronger mosquito repellent efficacy. DETAILED DESCRIPTION

[0061] The present application will be described in detail below through specific examples, so that the technical solution of the present application is easier to understand and master, but the present application is not limited thereto, and the described examples are only a part of the examples of the present application, rather than all the examples.

[0062] The endpoints of the ranges and any values disclosed in this document are not limited to the precise values stated. The ranges and values should be interpreted as being approximate. For numeric values, the endpoints of each range, the endpoints of each range and individual point values, and individual point values can be combined with each other to generate one or more new numeric ranges, which should be considered as specifically disclosed herein. As used herein, the singular forms "a", "an", and "the" include singular and plural referents unless the context clearly dictates otherwise. Numeric ranges expressed in terms of "from" and "to" include all numerical values between the recited endpoints and the recited endpoints.

[0063] All other examples obtained by those of ordinary skill in the art based on the examples in the present application without creative labor should fall within the scope of protection of the present application. In the following examples, the experimental methods described are conventional methods unless otherwise specified. The reagents and materials described are commercially available unless otherwise specified. The following reagent source information is exemplary and should not be considered limiting to the present application.

[0064] The CAS number of the alpha-ethylidene-benzaldehyde of the present application is 4411-89-6, the manufacturer of Ethylan NS-500LQ is AkzoNobel, the manufacturer of Atlas™ G-5002L is Dow Chemical, the manufacturer of TERMUL 5030 is Indorama, the CAS number of carboxymethyl cellulose is 9000-11-7, the CAS number of polydimethylsiloxane is 9016-00-6; the manufacturer and part number of polyether modified silicone is Ashland Drewplus T-4201A; the CAS number of TDI is 584-84-9, the CAS number of PAPI is 9016-87-9, the manufacturer of SP-3936 is Jiangsu Qinyu Chemical Technology Co., Ltd., the manufacturer of Tergitol XD is Dow Chemical, the manufacturer of citronella extract is Robertet Fragrances. The CAS number of the alpha-ethylidene-benzaldehyde of the present application is 4411-89-6, the manufacturer of Ethylan NS-500LQ is AkzoNobel, the manufacturer of Atlas™ G-5002L is Dow Chemical, the manufacturer of TERMUL 5030 is Indorama, the CAS number of carboxymethyl cellulose is 9000-11-7, the CAS number of polydimethylsiloxane is 9016-00-6; the manufacturer and part number of polyether modified silicone is Ashland Drewplus T-4201A; the CAS number of TDI is 584-84-9, the CAS number of PAPI is 9016-87-9, the manufacturer of SP-3936 is Jiangsu Qinyu Chemical Technology Co., Ltd., the manufacturer of Tergitol XD is Dow Chemical, the manufacturer of citronella extract is Robertet Fragrances.

[0065] Example 1-3 mosquito repellent emulsion

[0066] [Preparation method]

[0067] According to the formula of the mosquito repellent composition described in Table 1, the effective ingredient is used as the oil phase, water and emulsifier are used as the water phase, the oil phase is added to the water phase under shearing to form an oil-in-water emulsion, and finally other components are mixed uniformly to form the mosquito repellent emulsion.

[0068] Table 1 Formula of the mosquito repellent composition described in Examples 1-3 (unit: wt%)

[0069] Example 4-6 mosquito repellent microcapsule suspension

[0070] [Preparation method]

[0071] According to the formula of the mosquito repellent composition described in Table 2, the mosquito repellent effective ingredient and the first capsule wall material are used as the oil phase, water and emulsifier are used as the water phase, the oil phase is added to the water phase under shearing to form an oil-in-water emulsion, the second capsule wall material is added dropwise, and the microcapsule is formed after incubation at 30℃ for 2h, and finally other components are mixed uniformly to form the microcapsule suspension.

[0072] Table 2 Formula of the mosquito repellent composition described in Examples 4-6 (unit: wt%)

[0073] Effect evaluation

[0074] Test 1 Thermal storage stability of alpha-ethylidene-benzaldehyde

[0075] The emulsifiable concentrate and the capsule suspension of α-ethylidene-phenylacetaldehyde prepared in Examples 1-6 and the technical α-ethylidene-phenylacetaldehyde provided in Comparative Example 1 were respectively filled into 50 ml glass reagent bottles. After being placed in an oven at 54°C for 14 days, they were taken out. The content of α-ethylidene-phenylacetaldehyde in the samples on the 0th day and the 14th day of storage was respectively determined by gas chromatography and the thermal storage loss rate was calculated.

[0076] Table 3

[0077] Conclusion: It was found by the thermal storage experiment that the thermal storage loss rate of the technical α-ethylidene-phenylacetaldehyde of Comparative Example 1 after 14 days of thermal storage at 54°C was 7.08%. It was indicated that the thermal storage stability of the technical α-ethylidene-phenylacetaldehyde was poor; while the thermal storage loss rate of the emulsifiable concentrate or the capsule suspension of α-ethylidene-phenylacetaldehyde prepared in Examples 1-6 after 14 days of thermal storage at 54°C was all less than 2%, and the stability was significantly improved.

[0078] Test 2 Physical stability test

[0079] Comparative Examples 2-4 Mosquito repellent emulsifiable concentrates

[0080] [Preparation method]

[0081] According to the formula of the mosquito repellent composition described in Table 4, the effective ingredient was used as the oil phase, water and the emulsifier were used as the water phase, the oil phase was added to the water phase under shearing to form an oil-in-water emulsion, and finally other components were added and uniformly mixed to form the mosquito repellent emulsifiable concentrate.

[0082] Table 4 Formula of the mosquito repellent composition described in Comparative Examples 2-4 (unit: wt%)

[0083] Comparative Examples 5-7 Mosquito repellent capsule suspensions

[0084] [Preparation method]

[0085] According to the formula of the mosquito repellent composition described in Table 5, the mosquito repellent effective ingredient and the first capsule wall material were used as the oil phase, water and the emulsifier were used as the water phase, the oil phase was added to the water phase under shearing to form an oil-in-water emulsion, the second capsule wall material was added dropwise, and the microcapsules were formed after being incubated at 30°C for 2 h, and finally other components were added and uniformly mixed to form the mosquito repellent capsule suspension.

[0086] Table 5 Formula of the mosquito repellent composition described in Comparative Examples 5-7 (unit: wt%)

[0087] [Emulsion stability of α-ethylidene-phenylacetaldehyde preparation after thermal storage]

[0088] The emulsions of the alpha-ethylidene-benzaldehyde prepared in Examples 1-6 and the microcapsule suspensions were respectively filled into 50ml glass reagent bottles with the emulsions of the alpha-ethylidene-benzaldehyde and the microcapsule suspensions of Comparative Examples 2-7. The samples were taken out after being placed in an oven at 54°C for 14 days. The emulsion stability of the samples was observed.

[0089] Table 6

[0090] Conclusion: By observing the emulsion state of the examples and the comparative examples before and after heat storage, it is found that the emulsion state of the examples 1-6 is stable and uniform before and after heat storage; while the emulsions of the comparative examples 2-7 all appear to be separated and demulsified after heat storage, which indicates that the HLB of the emulsifiers used in the examples 1-6 is between 12-16; while the HLB of the emulsifiers EL-20, AEO-4 and Tween-20 used in the comparative examples 2-7 is 9-10, 9-10 and 16.5 respectively, which are all not within the range of 12-16, so the emulsions appear to be separated and demulsified. It is shown that the emulsion stability of the alpha-ethylidene-benzaldehyde prepared into the emulsion or the microcapsule suspension using the emulsifier with HLB value of 12-16 in the technical solution claimed in the present application is significantly improved after being stored at 54°C for 14 days.

[0091] Test 3 repellency persistence test

[0092] Experimental method: The alpha-ethylidene-benzaldehyde technical material and the alpha-ethylidene-benzaldehyde mosquito repellent emulsion or microcapsule suspension of Examples 1-6 were respectively sprayed on 20cm x 20cm non-woven fabric substrates in a certain amount of positive and negative, ensuring that each substrate contains 100mg of active ingredient, and then placed in a hollow plastic shell that can be hung. By using a 28m 3 The repellent effect of the test substrate was tested in a standard glass house under the specified temperature of 26°C±2°C and humidity of 60%±20% within a specified time, the glass house simulated the cabin of the repellent experiment, and 1 mouse was bound as a lure. 50 mosquitoes were put into the glass house for each experiment. The experiment was carried out in a dark condition with the lights off from 16:00 to 8:00. The blank control group was the substrate without spraying the liquid. The mosquitoes were collected the next day to observe the blood sucking, knockdown and death conditions. After the experiment, the substrate was stored in a climate chamber. The persistence of the sample was evaluated again after 1 month, 2 months and 3 months. The results are shown in Tables 7-10.

[0093] Table 7

[0094] Table 8

[0095] Table 9

[0096] Table 10

[0097] Conclusion: From the repellent experiment for 3 months, it is found that the blank sample without spraying the active ingredient has no repellent effect on Aedes on the first day and the first, second and third month, and the blood sucking rates are 100%, 100%, 96% and 98% respectively. The repellent effect of the sample sprayed with the α-ethylidene-hydratropic aldehyde of Comparative Example 1 is very good on the first day, and the blood sucking rate is 2%, which is consistent with the repellent effect of the α-ethylidene-hydratropic aldehyde EW and CS of Examples 1-6. With the increase of time, the blood sucking rates of the sample of Comparative Example 1 are increased to 20%, 48% and 64% on the first, second and third month respectively, which indicates that the persistence of the α-ethylidene-hydratropic aldehyde sprayed on the substrate is very short. The blood sucking rates of the samples of Examples 1-3 sprayed with the α-ethylidene-hydratropic aldehyde EW are 4%, 6%, 6%; 10%, 12%, 10%; 16%, 18%, 18% on the first, second and third month respectively. The blood sucking rates of the samples of Examples 4-6 sprayed with the α-ethylidene-hydratropic aldehyde CS are 0%, 2%, 2%; 2%, 0%, 2%; 4%, 2%, 4% on the first, second and third month respectively, which indicates that the persistence of the α-ethylidene-hydratropic aldehyde CS sprayed on the substrate is greater than or equal to 3 months; the persistence of the α-ethylidene-hydratropic aldehyde EW is 2 months, and the persistence of the α-ethylidene-hydratropic aldehyde is only about 1 month.

[0098] Examples 7-9: Repellent microcapsule suspensions

[0099] [Preparation method]

[0100] According to the formula of the repellent composition described in Table 8, the repellent active ingredient and the first capsule wall material are used as the oil phase, water and the emulsifier are used as the water phase, the oil phase is added to the water phase under shearing to form an oil-in-water emulsion, the second capsule wall material is added dropwise, and the microcapsules are formed by solidification at 30°C for 2 hours. Finally, the other components are added and uniformly mixed to form the microcapsule suspension.

[0101] Table 11: Formula of the repellent composition of Examples 7-9 (unit: wt%)

[0102] Test 4: Repellent test

[0103] Experimental method: The α-ethylidene-hydratropic aldehyde repellent microcapsule suspensions of Examples 4, 7-9 are sprayed on the 20 cm x 20 cm polyester fabric substrate in a certain amount, and each substrate contains 100 mg of active ingredient. Then, the substrate is placed in a hollow plastic shell that can be hung. A 28 m 3The standard glass simulation field tests the repellent effect of the test substrate at a specified temperature of 26℃±2℃ and humidity of 60%±20% within a specified time. The glass house simulates the cabin of the repellent experiment, and 1 mouse is bound as a lure. 50 mosquitoes are put into the glass house for each experiment. The experiment is performed in the dark condition of 16:00-8:00 with the light off. The blank control group is the substrate without spraying the liquid medicine. The mosquitoes are collected the next day to observe the blood sucking, knockdown and death.

[0104] Table 12

[0105] Conclusion: The four-fluorophenyl chrysanthemum, citronella extract and DEET are respectively compounded with α-ethylene-benzene acetaldehyde to prepare the two-component mosquito repellent microcapsule suspensions, and the repellent performance test is performed. It is found that the blank substrate sample without spraying the medicine has no repellent effect on the mosquitoes. The two-component mosquito repellent microcapsule suspensions prepared by compounding the citronella extract and DEET of examples 8 and 9 with α-ethylene-benzene acetaldehyde have similar repellent effect on the substrate after spraying, and the blood sucking rate is 2%. The two-component mosquito repellent microcapsule suspensions prepared by compounding the four-fluorophenyl chrysanthemum of example 7 with α-ethylene-benzene acetaldehyde have the best repellent effect on the substrate after spraying, and the blood sucking rate is 0%, and the knockdown effect of the sample is greatly increased due to the presence of the four-fluorophenyl chrysanthemum, and the knockdown rate is 52%. It is indicated that the mosquito repellent preparation prepared by compounding the four-fluorophenyl chrysanthemum with α-ethylene-benzene acetaldehyde has better effect.

[0106] Finally, it should be noted that the above content is only used to illustrate the technical solutions of the present application, and is not a limitation on the protection scope of the present application. Simple modifications or equivalent replacements of the technical solutions of the present application made by those skilled in the art do not deviate from the essence and scope of the technical solutions of the present application.

Claims

1. An insect repellent composition, characterized in that, 0.1-40% of mosquito-repelling effective component, 1-10% of emulsifier, 3-8% of anti-freezing agent, 0.1-3% of thickening agent, 0.1-2% of defoaming agent and the rest of water; or 0.1-40% of mosquito-repelling effective component, 1-10% of emulsifier, 1-10% of capsule wall material, 0.1-0.5% of pH regulator, 3-8% of anti-freezing agent, 0.1-3% of thickening agent, 0.1-2% of defoaming agent and the rest of water; The mosquito-repelling effective component contains α-ethylidene-acetophenone, its tautomer or its cis-trans isomer.

2. The mosquito-repelling composition according to claim 1, characterized by The mosquito-repelling effective component contains a second mosquito-repelling component, which is a chemical synthetic mosquito-repelling agent or a plant mosquito-repelling agent; the mass ratio of the α-ethylidene-acetophenone, its tautomer or its cis-trans isomer to the second mosquito-repelling component is 0.01-100:0-99.

99.

3. The mosquito-repelling composition according to claim 2, characterized by The chemical synthetic mosquito-repelling agent contains at least one of pyrethroid insecticides, organophosphorus insecticides, neonicotinoid insecticides, carbamate insecticides, bisamide insecticides, isoxazoline insecticides, DEET, diethyltoluamide, diethylmethylbutyl-amine and ethylhexanediol. The plant mosquito-repelling agent is extracted from plants, containing at least one of citronella, peppermint oil, Siberian fir, d-limonene, cedar, eucalyptus, peppermint, lemon grass, wormwood, tea tree and geranium.

4. The mosquito-repelling composition according to claim 1, characterized by, The HLB of the emulsifier ranges from 12 to 16; the capsule wall material is polyurea, polyurethane or polyamide; the anti-freezing agent is at least one of ethylene glycol, propylene glycol, glycerol and urea; the thickening agent is at least one of xanthan gum, polyethylene glycol, polyvinyl alcohol, magnesium aluminum silicate, carboxymethyl cellulose, bentonite, white carbon black, polyvinyl pyrrolidone and acrylic acid dispersion; and the defoaming agent is polydimethylsiloxane and / or polyether modified silicone.

5. The mosquito-repelling composition according to any one of claims 1 to 4, characterized in that, The mosquito-repelling composition is water emulsion or microcapsule suspension.

6. A process for the preparation of the mosquito-repelling composition according to any one of claims 1 to 5, characterized in that, The method comprises the following steps: The mosquito-repelling effective component is used as the oil phase, water and the emulsifier are used as the water phase, the oil phase is added into the water phase under shearing to form an oil-in-water emulsion, and finally other components are added and uniformly mixed to form the water emulsion; or The mosquito-repelling effective component and the first capsule wall material are used as the oil phase, water and the emulsifier are used as the water phase, the oil phase is added into the water phase under shearing to form an oil-in-water emulsion, the second capsule wall material is added dropwise, and solidification is performed to form microcapsules, and finally other components are added and uniformly mixed to form the microcapsule suspension.

7. An insect repellent product characterized in that, The mosquito-repelling composition is prepared by the method of any one of claims 1-5 or the preparation method of claim 6.

8. A method of repelling mosquitoes, characterized by, The mosquito-repelling composition is prepared by the method of any one of claims 1-5 or the preparation method of claim 6.

9. The method of repelling mosquitoes according to claim 8, wherein, The mosquito-repelling composition is loaded on a carrier, surface moisture is dried, and a mosquito-repelling carrier is obtained; the obtained mosquito-repelling carrier is placed in a mosquito-repelling target area, and the mosquito-repelling purpose is achieved through volatilization of the effective component.

10. A method of improving the thermal storage stability of an α-ethylidene-phenylacetaldehyde, characterized by, The method comprises the following steps: The content of the α-ethylidene-acetophenone is adjusted to 0.1-40wt%; The content of the emulsifier is adjusted to 1-10wt%; The content of the anti-freezing agent is adjusted to 3-8wt%; adjusting the content of the thickening agent to be 0.1-3wt%; adjusting the content of the defoaming agent to be 0.1-2wt%; adjusting the balance to be water; or adjusting the content of the α-ethylidene-benzaldehyde to be 0.1-40wt%; adjusting the content of the emulsifier to be 1-10wt%; adjusting the content of the capsule wall material to be 1-10wt%; adjusting the content of the pH regulator to be 0.1-0.5wt%; adjusting the content of the antifreeze agent to be 3-8wt%; adjusting the content of the thickening agent to be 0.1-3wt%; adjusting the content of the defoaming agent to be 0.1-2wt%; adjusting the balance to be water; the HLB of the emulsifier ranges from 12 to 16; the capsule wall material is polyurea, polyurethane or polyamide; the antifreeze agent is at least one of ethylene glycol, propylene glycol, glycerol and urea; the thickening agent is at least one of xanthan gum, polyethylene glycol, polyvinyl alcohol, magnesium aluminum silicate, carboxymethyl cellulose, bentonite, white carbon black, polyvinyl pyrrolidone and acrylic acid dispersion; the defoaming agent is polydimethylsiloxane and / or polyether modified silicone.

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