Hydrogen-rich coral calcium, compositions, manufacture and use thereof

Abstract

A hydrogen-rich coral calcium product or composition is disclosed. It comprises (a) a material of coral calcium, having pores; and (b) hydrogen gas (H2), carried in the coral calcium pores; wherein the hydrogen rich coral calcium product or composition is a solid form and possesses a property of continuous and stable release of the hydrogen gas for at least 3 hours when it is in water. A method of manufacturing a hydrogen-rich coral calcium product or composition of the invention is also disclosed.

Description

[0001] HYDROGEN-RICH CORAL CALCIUM, COMPOSITIONS, MANUFACTURE

[0002] AND USE THEREOF

[0003] FIELD OF THE INVENTION

[0004] The present invention relates generally to a hydrogen rich composition, and more specifically to a hydrogen rich adjuvant, formulation, manufacture and use thereof.

[0005] BACKGROUND OF THE INVENTION

[0006] Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals in cultured cells using hydrogen water, and in an acute rat model using inhalation of 2% hydrogen gas (Ohsawa et al. “Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals” 2007, Nat Med 13, 688-694). A large amount of research and data prove hydrogen molecules have unique water and lipid soluble properties. As the smallest molecule, hydrogen can effectively remove cytotoxic oxygen radicals, restore youthful state and delay aging of the body. Hydrogen gas cannot be stored in the body. Whether hydrogen gas is inhaled or introduced through drinking water, almost all of it is excreted from the body after 15 min (Imaoka et al. “A basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H2 level” Med Gas Res. 2012; 2:21). Moreover, current hydrogen-rich foods are still relatively low in hydrogen content and have high production costs.

[0007] Therefore, there is a need in the art to address the aforementioned deficiencies and inadequacies related to hydrogen rich supplements, especially in connection with preparations and manufacture of hydrogen rich compositions for use as an adjuvant in adjunct therapy.

[0008] SUMMARY OF THE INVENTION

[0009] In one aspect, the invention relates to a hydrogen-rich coral calcium product or composition, comprising: (a) a material of coral calcium, having pores; and (b) hydrogen gas (Hz), carried in the coral calcium pores; wherein the hydrogen-rich coral calcium product or composition is a solid form and possesses a property of continuous and stable release of the hydrogen gas for at least 3 hours when it is in water. In one embodiment of the invention, the hydrogen-rich coral calcium product or composition displays structure-well-defined pore spaces in the skeletons of the coral calcium, which can be seen under an electronic microscope as shown in FIG. 1 A.

[0010] In another embodiment, the material of the coral calcium is un-pulverized.

[0011] In another embodiment of the invention, the coral calcium is heat-treated or burnt product.

[0012] In another embodiment, the coral calcium is heat-treated or brunt product and un-pulverized.

[0013] In another embodiment, the hydrogen-rich coral calcium product or composition possesses a property of continuous and stable release of the hydrogen gas for at least 6 hours when it is present in water.

[0014] In another embodiment, the hydrogen-rich coral calcium product or composition possesses a property of continuous and stable release of the hydrogen gas for at least 24 hours when it is present in water.

[0015] In another embodiment, the hydrogen-rich coral calcium product or composition possesses a property of continuous and stable release of the hydrogen gas for at least 48 horns when it is in water.

[0016] In another aspect, the invention relates to a method of manufacturing a hydrogen-rich coral calcium product or composition of the invention, the method comprising the steps of: (a) providing a material of coral calcium to a closed chamber; (b) increasing the temperature of the chamber to 350 °C to 400 °C under a condition of precise heating and simultaneously maintaining the chamber a negative pressure; (c) maintaining the chamber temperature at 350 °C to 400 °C for at least Ihr to bum the material of coral calcium for a period to afford burnt coral calcium; (d) pressuring hydrogen gas of more than Ipsi into the chamber to afford a product of hydrogen-rich coral calcium or a hydrogen-rich coral calcium composition; (e) cooling down the chamber to room temperature under a condition of precise cooling; and (f) starting a second cycle by repeating the above steps (a), (b), (c), (d) and (e).

[0017] In one embodiment, the method may further comprise the step of starting a third cycle by repeating the above steps (a), (b), (c), (d) and (e).

[0018] In another embodiment of the method invention, the closed chamber is housed in a room with humidity controlled below 45%, 55 or 65%.

[0019] In another embodiment, the precise heating condition is at a heating rate of 3 degree Celsius per minute (3 °C / min). In another embodiment, the precise cooling condition is at a cooling rate of 3 °C / min.

[0020] The method may further comprise the step of pulverizing the hydrogen rich coral calcium to obtain hydrogen-rich coral calcium in a powder form or hydrogen rich coral calcium powder.

[0021] In one embodiment, the method further comprises the step of: placing the hydrogen-rich coral calcium powder in a capsule to afford a hydrogen capsule.

[0022] In another aspect, the invention relates to a hydrogen-rich coral calcium product or composition which is manufactured by a method of the invention.

[0023] In another aspect, the invention relates to a hydrogen-rich coral calcium, oyster calcium or eggshell product or composition, comprising:

[0024] (a) a material of coral calcium, oyster calcium or eggshell, having pores; and

[0025] (b) hydrogen gas, carried in the coral calcium, oyster calcium or eggshell pores; wherein the hydrogen-rich calcium, oyster calcium or eggshell product or composition is a solid form and possesses a property of continuous and stable release of the hydrogen gas for at least 3 hours when it is in water.

[0026] In another aspect, the invention relates to a hydrogen-rich coral calcium product or composition of the invention for use in an adjunct therapy for preventing formation and / or retarding progression of a disorder or a disease selected from the group consisting of: Sjogren's syndrome, primary pulmonary arterial hypertension, heart failure, chronic kidney disease (CKD), interstitial lung disease, chronic obstructive pulmonary diseases, metabolic syndrome, hyper triglycerides, nonalcoholic fatty liver disease (NAFLD), altered gut microbiota (dysbiosis), and alcoholic hepatitis in a subject in need thereof.

[0027] These and other aspects will become apparent from the following description of the preferred embodiment taken in conjunction with the following drawings, although variations and modifications therein may be affected without departing from the spirit and scope of the novel concepts of the disclosure.

[0028] The accompanying drawings illustrate one or more embodiments of the invention and, together with the written description, serve to explain the principles of the invention. Wherever possible, the same reference numbers are used throughout the drawings to refer to the same or like elements of an embodiment.

[0029] BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 A is an electron microscopy photograph of a hydrogen-rich coral calcium or coral calcium product according to one embodiment of the invention. It displays good porosity, with well-defined pore spaces in the skeleton of the coral or coral calcium.

[0030] FIG. IB is an electron microscopy photograph of a hydrogen-rich coral calcium or coral calcium product made by an old, known process (prior art). It displays poor porosity and appears fragmented.

[0031] FIG. 1C is a graph showing the Oxidation-Reduction Potential (0RP)(mV) versus time (hrs) of hydrogen rich water (HRW), hydrogen-rich coral calcium (HRCC) according to one embodiment of the invention from FIG. 1 A, and prior art (PA) hydrogen-rich coral calcium (Old- HRCC) from FIG. IB.

[0032] FIG. 2 is a scheme illustrating the manufacture process of a hydrogen-rich coral calcium product according to one embodiment of the invention.

[0033] DETAILED DESCRIPTION OF THE INVENTION

[0034] DEFINITIONS

[0035] The terms used in this specification generally have their ordinary meanings in the art, within the context of the invention, and in the specific context where each term is used. Certain terms that are used to describe the invention are discussed below, or elsewhere in the specification, to provide additional guidance to the practitioner regarding the description of the invention. For convenience, certain terms may be highlighted, for example using italics and / or quotation marks. The use of highlighting has no influence on the scope and meaning of a term; the scope and meaning of a term is the same, in the same context, whether or not it is highlighted. It will be appreciated that same thing can be said in more than one way. Consequently, alternative language and synonyms may be used for any one or more of the terms discussed herein, nor is any special significance to be placed upon whether or not a term is elaborated or discussed herein. Synonyms for certain terms are provided. A recital of one or more synonyms does not exclude the use of other synonyms. The use of examples anywhere in this specification including examples of any terms discussed herein is illustrative only, and in no way limits the scope and meaning of the invention or of any exemplified term. Likewise, the invention is not limited to various embodiments given in this specification. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. In the case of conflict, the present document, including definitions will control.

[0036] As used herein, “around”, “about” or “approximately” shall generally mean within 20 percent, preferably within 10 percent, and more preferably within 5 percent of a given value or range. Numerical quantities given herein are approximate, meaning that the term “around”, “about” or “approximately” can be inferred if not expressly stated.

[0037] The term “adjuvant” as used herein means one that helps or facilitates such as (a) an ingredient that modifies the action of the principal ingredient; (b) something (such as a drug or method) that enhances the effectiveness of medical treatment; (c) a substance enhancing the immune response to an antigen; and (d) something (such as a drug or method) that suppress the negative side effect of medical treatment.

[0038] The term “adjunct” as used herein means something else as a supplementary rather than an essential part. An adjunct means another treatment used together with the primary treatment. Its purpose is to assist the primary treatment. Also called adjunctive therapy. A supplementary, or adjunctive, treatment is administered in conjunction with a patient’s ongoing antirheumatic therapy, in an attempt to treat symptoms or improve functions that are not addressed by the antirheumatic alone.

[0039] The term “treating”, “treat” or “treatment” as used herein includes preventative (e.g., prophylactic) and palliative treatment.

[0040] By “pharmaceutically acceptable” is meant the vehicle, carrier, diluent, excipients, and / or salt must be compatible with the other ingredients of the formulation, and not deleterious to the recipient thereof

[0041] The quantity and nature of the pharmaceutically appropriate vehicle, carrier, diluent, excipients, and / or salt can be easily determined by a person skilled in the art. They are chosen according to the desired pharmaceutical form and method of administration.

[0042] In one embodiment, the hydrogen-rich coral calcium product or composition is unpulverized.

[0043] EXAMPLES

[0044] Without intent to limit the scope of the invention, exemplary instruments, apparatus, methods and their related results according to the embodiments of the present invention are given below. Note that titles or subtitles may be used in the examples for convenience of a reader, which in no way should limit the scope of the invention. Moreover, certain theories are proposed and disclosed herein; however, in no way they, whether they are right or wrong should limit the scope of the invention so long as the invention is practiced according to the invention without regard for any particular theory or scheme of action.

[0045] Methods, Materials and Results

[0046] Manufacture:

[0047] Coral materials (supplier Ace Plan Co., Ltd.) were placed in a closed chamber and heated by gradually increasing the temperature under a precise heating condition at a heating rate of 3 degree Celsius per minute (3 °C / min). As the temperature was rising, the chamber was simultaneously vacuumed or maintained a negative pressure. The chamber temperature was kept at between 350 °C and 400 °C for about one hour, then hydrogen gas of more than lpsi was applied into the chamber to obtain the product of hydrogen-rich coral calcium. As the hydrogen gas was pressured into the chamber, precise cooling was started at a cooling rate of 3 °C / min. Once the chamber temperature reached the room temperature, a second cycle started, that is, the steps of precise heating, temperature maintaining, precise cooling, hydrogen pressuring as aforementioned were repeated.

[0048] At least two to three cycles are required for manufacture of a hydrogen-rich coral calcium product or composition of the invention (FIG. 2). The closed chamber is housed in a room with humidity being controlled below 65%~45% throughout the manufacturing process. The closed chamber may be housed in a room with humidity controlled below 65%. Preferably, the closed chamber is housed in a room with humidity below 55%. More preferably, the closed chamber is housed in a room with humidity below 45%.

[0049] The hydrogen-rich coral calcium was then pulverized to obtain hydrogen rich coral calcium in powder form (hydrogen rich coral calcium powder). Hydrogen rich coral powder was placed inside a capsule as a dosage form.

[0050] It was discovered that the heating and the cooling rate both have an impact on the hydrogen contents of the products as the oxidation-reduction potential (mV) versus time (hrs) (as shown in FIG. 1C) values were not the same. In addition, the EM structure also differed dramatically. It is critical that the heating and the cooling rate is kept at no higher than 3 °C / min. When the rate was smaller than or equal to 3 °C / min, the coral structure appeared perfect, its original skeleton structure was not destructed or damaged. On the opposite, when the heating and / or the cooling rate was higher than 3 °C / min, the coral structure became damaged, appeared fragmented like FIG. IB, and the hydrogen content reduced as reflected in the oxidation-reduction potential (mV) versus time study. Furthermore, if a coral calcium material was pulverized into powder first before it was burnt to afford burnt coral calcium, then the resulted hydrogen coral calcium powder appeared fragmented, losing well-defined pore structures. The chamber temperature maintaining at 350 °C ~ 400 °C is also important. It was found that a chamber temperature over 350 °C ~ 400 °C range during burning the coral calcium gave rise to a final hydrogen coral calcium product that has a fragmented, ugly structure. A chamber temperature below 350 °C during burning of the coral calcium gave rise to a hydrogen coral calcium product with low hydrogen contents and its oxidation-reduction potential (mV) versus time curve like FIG. 1C, old prior art product.

[0051] FIG. 1 A is an electron microscopy photograph of a hydrogen-rich coral calcium product in a powder form (the invention), which was manufactured according to one embodiment of the method invention. The hydrogen-rich coral calcium product of the invention displays good porosity (magnification 1809 x) with clear and well-defined pore spaces in the skeleton of the coral calcium.

[0052] FIG. IB shows an electron microscopy photograph of a hydrogen-rich coral calcium product in a powder form that was manufactured according to a method disclosed in patent publication number CN 101971892 A. Briefly, a material of coral calcium was powdered first, then soaked in an alcohol mixture (methanol: ethanol: propanol = 1 : 1: 1) for 3.5 hours, followed by heating to 400 °C and maintaining at 400 °C for 5 hours, then cooling down to the room temperature to obtain hydrogenated coral powder. The hydrogen coral calcium powder (i.e., prior art method- made product) displayed poor porosity (magnification 4000 x) that did not have clear and well- defined pore spaces in the skeleton of the coral calcium.

[0053] We investigated the oxidation-reduction potential (mV) of three hydrogen-rich products: (1) hydrogen-rich water (HRW); (2) hydrogen-rich coral calcium product in powder form (HRCC) according to one embodiment of the invention; and (3) hydrogen-rich coral calcium powder product made by an old, known process.

[0054] FIG. 1C shows oxidation-reduction potential (mV) versus time (hrs) relationship. Hydrogenrich water (solid circle), hydrogen-rich coral calcium powder made by a prior art method in the distilled water (solid triangle), and a hydrogen coral calcium product in powder form according to one embodiment of the invention in the distilled water (solid square ). Hydrogen-rich water or hydrogen-containing water (HRW) was obtained as follows: A hydrogen generator was used to electrolyze pure water to generate hydrogen gas. The hydrogen gas was then directed to enter water (100 ml) through a tube and mixed thoroughly with the water for 10 minutes to obtain hydrogen-rich water (HRW).

[0055] The hydrogen-rich coral calcium product or composition according to the invention possesses a property of continuous and stable release of hydrogen gas for at least 48 hours when it is in water. For example, a hydrogen-rich coral calcium product or composition in powder form according to the invention possesses a property of continuous and stable release of hydrogen gas for 72 hours or more than 100 hours. In other words, we could still detect hydrogen gas release into water when the hydrogen-rich coral calcium product of the invention is present in water for more than 72 hours or even more than 100 hours.

[0056] FIG. 2 is a scheme that illustrates the manufacture process of a hydrogen-rich coral calcium product according to one embodiment of the invention.

[0057] A hydrogen-rich coral calcium product may be further pulverized to afford a form of powder. A powder form of hydrogen-rich coral calcium may be added into a capsule to afford a hydrogen capsule. Each hydrogen capsule may contain 170 mg Hydrogen-Rich Coral Calcium (HRCC) with 1.7 x 1021molecules of hydrogen (around 24 cups of 1,200 ppb / 0.6 mM, 200 ml of Hydrogen Water).

[0058] Coral calcium can be replaced with oyster calcium or eggshell to manufacture a hydrogenrich oyster calcium or eggshell product or composition using a similar manufacture process as aforementioned. A hydrogen-rich coral calcium, oyster calcium or eggshell product or composition comprises (a) a material of coral calcium, oyster calcium or eggshell, having pores; and (b) hydrogen gas, carried in the coral calcium, oyster calcium or eggshell pores; wherein the hydrogen-rich calcium, oyster calcium or eggshell product or composition is a solid form and possesses a property of continuous and stable release of the hydrogen gas for at least 3 hours when it is in water.

[0059] Clinical applications

[0060] Hydrogen capsules are used as an adjuvant in adjunctive supplement in patients who can benefit from hydrogen molecules supplements. The studies of clinical human and non-human animal applications of hydrogen capsules according to one embodiment of the invention indicated that there were a statistic difference between the adjunct therapy and control groups in the patients afflicted with one of the following disorders or diseases: autoimmune disease, Sjogren's syndrome, primary pulmonary arterial hypertension, heart failure, chronic kidney disease (CKD), interstitial lung disease, chronic obstructive pulmonary diseases, metabolic syndrome, hyper triglycerides, nonalcoholic fatty liver disease (NAFLD), altered gut microbiota (dysbiosis), and alcoholic hepatitis.

[0061] Example 1 :

[0062] A clinical trial report of Hydrogen capsules in Rheumatoid Arthritis (RA) Syndrome can improve patients’ life quality and fatigue. Hydrogen capsules, each containing: (1) coral calcium 170 mg; (2) maltitol 174 mg; (3) Hydroxypropyl Methylcellulose (the material of capsule) 60 mg; (4) Ascorbic Acid (Vitamin C) 29.43mg; (5) Nicotinic Acid 4.45 mg; and (6) Calcium Stearate 11.5 mg, were administered to patients suffering from rheumatologic or autoimmune diseases. The “Rheumatoid Arthritis Scale DAS-28” used to diagnose rheumatoid arthritis showed improvement in rheumatoid arthritis condition. The “Fatigue Inventory BFLT” used to diagnose fatigue status showed improvement in patients' fatigue.

[0063] (Shen M , Chung JC , Wang K , Chu C , Tsou W , Chou H , Wang T , Chang T , Chen W , Liu F , Douglas FL , Hsieh R, Evaluation of the Safety and Potential Therapeutic Effects of Hydrogen- Rich Coral Calcium on Autoimmune Diseases, Research Square, Volume 13, Issue 12 2022) Example 2\

[0064] A case report of molecular hydrogen therapy in Sjogren's Syndrome with pulmonary arterial hypertension and right-sided heart failure. The study showed improved immune markers including Treg, B cells and plasma cells.

[0065] The increase in Treg indicates an improvement in the regulatory ability of the immune system and improvement the kidney function. The decrease in B cells indicates an improvement in the abnormal autoimmune response. The reduction of Plasma cells indicates the improvement of abnormal autoimmune response. Reduction of anti-Ro indicates improvement of abnormal autoimmune response. (Y.T Lin, J.W. Lu, C.H. Wu, Y.J. Ho, S.W Lui, TY Hsieh, F.C. Liu, Molecular Hydrogen Therapy in Sjogren’s Syndrome with Pulmonary Arterial Hypertension and Right-Sided Heart Failure: A Case Report of Improved Immune Markers including Treg B cells and plasma cell, In Vivo under review 2024)

[0066] Example 3;

[0067] A case report of molecular hydrogen therapy in interstitial lung disease Syndrome with chronic lung inflammation. The study showed improved immune markers Increased Resting Treg Cells or Decreased Fas+ T Cell Subsets in a IgG4-PF-ILD Patient. The increase in Treg indicates an improvement in the regulatory ability of the immune system and improvement the kidney function. It indicates an improvement in the abnormal autoimmune response, decrease chronic lung inflammation. And it indicate it may improve the Chronic Obstructive Pulmonary Diseases (COPD).

[0068] (S.W. Lui, J.W. Lu, Y.J. Ho, S.E. Tang, K.H. Ko, TY. Hsieh, F.C. Liu, Molecular Hydrogen as a Promising Therapy Could Be Linked With Increased Resting Treg Cells or Decreased Fas+ T Cell Subsets in a IgG4-PF-ILD Patient: A Case Report, In Vivo 38: 1512-1518 2024)

[0069] Example 4\

[0070] A clinical trial report of molecular hydrogen therapy in Metabolic Syndrome improves Hyper Triglycerides Syndrome. The study showed improved Patients’ health, result is lipid- lowering effects in a month.

[0071] The decreased Triglycerides indicated an improvement in the metabolic ability of lipid-lowering effects. It indicates an improvement in the metabolic response, decrease inflammation. It also indicated it may improve life quality.

[0072] (S.H. Chiu, F.L. Douglas, J.R. Chung, K.Y Wang, C.F. Chu, H.Y Chou, W.C. Huang, T.Y Wang, W.W. Chen, M.C. Shen, F.C. Liu, P.J. Hsiao, Evaluation of the safety and potential lipid-lowering effects of oral hydrogen-rich coral calcium (HRCC) capsules in patients with metabolic syndrome: a prospective case series study, Front Nutr. 102023)

[0073] Example 5;

[0074] A case report of molecular hydrogen therapy improves patients’ Chronic kidney disease, CKD. The study showed patients’ energy improved, decreased chronic fatigue. It indicates molecular hydrogen therapy inhibits the generation of mitochondrial ROS (mtROS), reduces mitochondrial damage, Chronic kidney disease, CKD. (C.M. Zheng, YC. Hou, M.T. Liao, K.W. Tsai, W.C. Hu, C.C. Yeh, K.C. Lu, Potential role of molecular hydrogen therapy on oxidative stress and redox signaling in chronic kidney disease, Biomed Pharmaco ther 176 2024). Example 6;

[0075] An animal study of molecular hydrogen therapy in nonalcoholic fatty liver disease, NAFLD Syndrome with liver inflammation. The study showed alters gut microbiome. It indicates molecular hydrogen therapy improve gut microbiome and lead to decrease live inflammation. (H.T. Wu, TH. Chao, H. Y. Ou, L.M. Tsai, A novel antioxidant hydrogen-rich coral calcium alters gut microbiome and bile acid synthesis to improve methionine-and- choline-deficient diet-induced non-alcoholic fatty liver disease, Antioxidants 13(6) 2024).

[0076] Example 7:

[0077] An animal study of molecular hydrogen therapy in Alcoholic hepatitis Syndrome with liver inflammation. The study showed improved inflammation markers TNF-a, IL-6, CCL2 and increases anti-oxidative enzyme levels in Catalase, GPx, MnSOD. These results indicate that molecular hydrogen therapy improve anti-oxidative enzyme levels and lead to a decrease in liver inflammation. (H.T. Wu, T.H. Chao, H.Y. Ou, L.M. Tsai, Coral hydrate a novel antioxidant improves alcohol intoxication in mice, Antioxidants 11(7) 2022).

[0078] The foregoing description of the exemplary embodiments has been presented only for the purposes of illustration and description and is not intended to be exhaustive to limit the invention to the precise forms disclosed. All references cited and discussed in this specification are incorporated herein by reference in their entireties and to the same extent as if each reference was individually incorporated by reference.

Claims

CLAIMSWhat is claimed is:

1. A hydrogen-rich coral calcium product or composition, comprising:(a) a material of coral calcium, having pores; and(b) hydrogen gas (Hz), carried in the coral calcium pores; wherein the hydrogen-rich coral calcium product or composition is a solid form and possesses a property of continuous and stable release of the hydrogen gas for at least 3 hours when it is in water.

2. The hydrogen-rich coral calcium product or composition of claim 1, displaying structure- well-defined pore spaces in the skeletons of the coral calcium, which can be seen under an electronic microscope as shown in FIG. 1 A.

3. The hydrogen-rich coral calcium product or composition of claim 1 or 2, wherein the material of the coral calcium is un-pulverized.

4. The hydrogen-rich coral calcium product or composition of claim 1 or 2, wherein the coral calcium is heat-treated or burnt product.

5. The hydrogen-rich coral calcium product or composition of claim 1 or 2, wherein the coral calcium is heat-treated or burnt product and un-pulverized.

6. The hydrogen-rich coral calcium product or composition of claim 1 or 2, which possesses a property of continuous and stable release of the hydrogen gas for at least 6 hours when it is present in water.

7. The hydrogen-rich coral calcium product or composition of claim 1 or 2, which possesses a property of continuous and stable release of the hydrogen gas for at least 24 hours when it is present in water.

8. The hydrogen-rich coral calcium product or composition of claim 1 or 2, which possesses a property of continuous and stable release of the hydrogen gas for at least 48 hours when it is in water.

9. A method of manufacturing a hydrogen-rich coral calcium product or composition as claimed in claim 1, comprising the steps of:(a) providing a material of coral calcium to a closed chamber;(b) increasing the temperature of the chamber to 350 °C to 400 °C under a condition of precise heating and simultaneously maintaining the chamber a negative pressure;(c) maintaining the chamber temperature at 350 °C to 400 °C for at least Ihr to bum the material of coral calcium for a period to afford burnt coral calcium;(d) pressuring hydrogen gas of more than lpsi into the chamber to afford a product of hydrogen-rich coral calcium or a hydrogen-rich coral calcium composition;(e) cooling down the chamber to room temperature under a condition of precise cooling; and(f) starting a second cycle by repeating the above steps (a), (b), (c), (d) and (e).

10. The method of claim 9, further comprising: starting a third cycle by repeating the above steps (a), (b), (c), (d) and (e).

11. The method of claim 9 or 10, wherein the closed chamber is housed in a room with humidity controlled below 45%, 55 or 65%.

12. The method of claim 9 or 10, wherein the precise heating condition is at a heating rate of 3 degree Celsius per minute (3 °C / min).

13. The method of claim 9 or 10, wherein the precise cooling condition is at a cooling rate of 3 °C / min.

14. The method of claim 9 or 10, further comprising the step of:pulverizing the hydrogen-rich coral calcium to obtain hydrogen-rich coral calcium in a powder form.

15. The method of claim 14, further comprising the step of: placing the hydrogen-rich coral calcium powder in a capsule to afford a hydrogen capsule.

16. The method of claim 9 or 10, further comprising the step of: starting a third cycle by repeating the steps (a), (b), (c), (d) and (e).

17. A hydrogen-rich coral calcium, oyster calcium or eggshell product or composition, comprising:(a) a material of coral calcium, oyster calcium or eggshell, having pores; and(b) hydrogen gas, earned in the coral calcium, oyster calcium or eggshell pores; wherein the hydrogen-rich calcium, oyster calcium or eggshell product or composition is a solid form and possesses a property of continuous and stable release of the hydrogen gas for at least 3 hours when it is in water.

18. A method of manufacturing a hydrogen-rich coral calcium product or composition, comprising the steps of:(a) providing a material of coral calcium to a closed chamber;(b) increasing the temperature of the chamber to 350 °C to 400 °C under a condition of precise heating and simultaneously maintaining the chamber a negative pressure;(c) maintaining the chamber temperature at 350 °C to 400 °C for at least Ihr to bum the material of coral calcium for a period to afford brunt coral calcium;(d) pressuring hydrogen gas of more than Ipsi into the chamber to afford a product of hydrogen-rich coral calcium or a hydrogen-rich coral calcium composition;(e) cooling down the chamber to room temperature under a condition of precise cooling; and(f) starting a second cycle by repeating the above steps (a), (b), (c), (d) and (e);wherein the hydrogen-rich coral calcium product or composition comprises: (i) a material of coral calcium, having pores; and (ii) hydrogen gas (H2), carried in the coral calcium pores; further wherein the hydrogen-rich coral calcium product or composition is a solid form and possesses a property of continuous and stable release of the hydrogen gas for at least 3 hours when it is in water .

19. The method of claim 18, further comprising: starting a third cycle by repeating the above steps (a), (b), (c), (d) and (e).

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