Disinfectant composition

Abstract

The purpose of the present invention is to provide a disinfectant that is effective for inactivating spore-forming bacteria. This disinfectant composition is acidic and comprises (A) ethanol, (B) water, and (C) a compound selected from the group consisting of (C1) halogenated salts and (C2) non-halogenated metal compounds. The disinfectant composition can inactivate spore-forming bacteria.

Description

Disinfectant Composition

[0001] The present invention relates to disinfectant compositions that are effective in inactivating spore-forming bacteria.

[0002] When spore-forming bacteria find it difficult to divide and multiply as vegetative bacteria, they form spores inside bacterial cells and distribute the replicated genes inside the spores. These spores are extremely durable and can survive even if the bacterial body dies. When the environment improves, the spores germinate, revert to bacteria, and multiply again.

[0003] Clostridioides difficile is an anaerobic, gram-positive, spore-forming bacillus known to be a causative agent of antibiotic-associated enteritis and nosocomial infections. Clostridioides difficile spores are present in the environment surrounding patients with Clostridioides difficile infection (CDI). Furthermore, as mentioned above, spores are highly durable, allowing them to survive and regrow for long periods in the environment, easily leading to nosocomial infection. Once a CDI outbreak occurs, responding to it is extremely difficult. Therefore, disinfection against spore-forming bacteria is extremely important.

[0004] To inactivate spores formed by spore-forming bacteria, high-level disinfectants, which are classified by antimicrobial spectrum, must be used. Specific examples of high-level disinfectants include glutaral preparations, phthalaral preparations, and peracetic acid preparations (Non-Patent Document 1). These high-level disinfectants are used to disinfect medical instruments such as endoscopes. Glutaral preparations generate toxic aldehyde gas, so caution is required to prevent mucosal damage and respiratory disorders. Although phthalaral preparations reduce the generation of aldehyde gas to 1 / 20 of that of glutaral preparations, the generation of aldehyde gas is unavoidable. Peracetic acid preparations do not generate harmful gases but are corrosive to metals.

[0005] Journal of the Japanese Society of Internal Medicine, Vol. 99, No. 8: 1916-1922, 2010

[0006] The current high-level disinfectants used to inactivate spore-forming bacteria require ventilation of toxic volatile gases and the wearing of protective gear to prevent direct skin contact with the disinfectant due to the nature of their active ingredients. As such, the current high-level disinfectants used to inactivate spore-forming bacteria have many limitations when used, so new options for disinfectants that can inactivate spore-forming bacteria are needed.

[0007] Therefore, an object of the present invention is to provide a disinfectant that is effective in inactivating spore-forming bacteria.

[0008] The present inventors have conducted extensive research and found that spore-forming bacteria can be inactivated by adding a compound selected from the group consisting of halide salts and non-halogenated metal compounds to an aqueous ethanol solution. The present invention was completed through further research based on this finding.

[0009] That is, the present invention provides the following aspects of the invention. Item 1. A disinfectant composition according to Item 1-1 or 1-2 below. Item 1-1. A disinfectant composition comprising (A) ethanol, (B) water, and (C) a specific compound selected from the group consisting of (C1) a halide salt and (C2) a non-halogenated metal compound, and which is acidic. Item 1-2. A disinfectant composition comprising (A) ethanol, (B) water, and (C) a specific compound, wherein the component (C) is (C1) potassium chloride, and which is acidic. Item 2. Item 1. The disinfectant composition according to Item 1, further comprising a component (D) selected from the group consisting of the following compounds: (D1) a substituted or unsubstituted phenolic compound selected from the group consisting of phenol and phenoxy alcohol, (D2) a phenylcarboxylic acid compound containing a substituted or unsubstituted phenyl group and an H-type, salt-type, or esterified carboxyl group, and (D3) a substituted benzene having a substituent other than a carboxyl group. Item 3. The disinfectant composition according to Item 1 or 2, further comprising (E) a component selected from the group consisting of (E1) a sugar alcohol, (E2) a monosaccharide, and (E3) a polyhydric alcohol. Item 4. The disinfectant composition according to any one of Items 1-1 and 2 to 3, wherein the component (C1) is selected from the group consisting of an alkali metal halide salt, an alkaline earth metal halide salt, an ammonium halide salt, and a quaternary ammonium halide salt. Item 5. The disinfectant composition according to any one of Items 1-1 and 2 to 4, wherein the component (C1) is potassium chloride. Item 6. Item 7. The disinfectant composition according to any one of Items 1-1 and 2 to 5, wherein the component (C2) is selected from the group consisting of alkali metal hydroxides, alkaline earth metal hydroxides, alkali metal salts of organic acids, and alkaline earth metal salts of organic acids. Item 8. The disinfectant composition according to any one of Items 1-1 and 2 to 5, wherein the component (D1) is a substituted or unsubstituted phenol represented by the following formula (5) and a substituted or unsubstituted phenoxy alcohol represented by the following formula (6): [In formula (5) and formula (6), R 13 is hydrogen, halogen, or an alkyl group having 1 to 6 carbon atoms, n4 is an integer of 1 to 6, and R 13 is other than hydrogen, R 13 The number of is 1 to 3, and R 13When the number of R is 2 or 3, each R 13 Item 8. The disinfectant composition according to any one of Items 2 to 6, wherein R is selected from the group consisting of: 13 is hydrogen or a methyl group, and R 13 is a methyl group, R 13 Item 7. The disinfectant composition according to Item 7, wherein the number of n is 1 and n4 is an integer of 1 to 6. Item 9. The disinfectant composition according to any of Items 2 to 8, wherein the component (D1) is selected from the group consisting of phenol, 2-phenoxyethanol, and 3-phenoxy-1-propanol. Item 10. The disinfectant composition according to any of Items 2 to 8, wherein the component (D2) is a compound represented by the following formula (7): [In formula (7), R 14 is a hydrogen atom, an alkali metal ion, an alkyl group having 1 to 4 carbon atoms, which may be substituted or unsubstituted with a hydroxyl group, or a substituted or unsubstituted aryl group or aralkyl group having 6 to 14 carbon atoms; R 15 is an unsubstituted or substituted alkylene group having 1 to 6 carbon atoms and a hydroxyl group as a substituent, and R 16 is hydrogen or a hydroxyl group, and R 17 is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a hydroxyl group, an aldehyde group, or an amino group, n5 is a number of 0 or 1, and R 17 is other than hydrogen, R 17 The number of is 1 to 2, and R 17 When the number of R is two, each R 17 may be the same or different. Item 11. The disinfectant composition according to any one of Items 2 to 9, wherein the component (D2) is a compound represented by the following formula (7-1): salicylic acid or a salt or derivative thereof, and benzoic acid or a salt or derivative thereof represented by the following formula (7-2): [In formula (7-1), R 14 represents a hydrogen atom, an alkali metal ion, or an alkyl group having 1 to 4 carbon atoms, which may be substituted with a hydroxyl group or may be unsubstituted, and in formula (7-2), R 14is hydrogen, an alkali metal ion, or an unsubstituted alkyl group having 1 to 4 carbon atoms. Item 12. The disinfectant composition according to any of Items 2 to 11, wherein the component (D2) is selected from the group consisting of salicylic acid, methyl salicylate, 2-hydroxyethyl salicylate, and benzoic acid. Item 13. The disinfectant composition according to any of Items 2 to 12, wherein the component (D) is the component (D2), and the component (D2) is 2-hydroxyethyl salicylate and / or methyl salicylate. Item 14. The disinfectant composition according to any of Items 2 to 12, wherein the component (D3) is a compound represented by the following formula (8): [In formula (8), R 18 is an alkyl group having 1 to 4 carbon atoms, halogen, or amino group, which may or may not have a hydroxyl group as a substituent; R 18 The number of is 1 to 4, and R 18 When the number of R is two or more, each R 18 Item 15. The disinfectant composition according to any one of Items 2 to 13, wherein R 18 is an alkyl group having 1 to 4 carbon atoms and having a hydroxyl group as a substituent, and R 18The disinfectant composition according to Item 14, wherein the number of (D3) is 1. Item 16. The disinfectant composition according to any of Items 2 to 15, wherein the component (D3) is benzyl alcohol. Item 17. The disinfectant composition according to any of Items 3 to 16, wherein the component (E1) is sorbitol and / or xylitol. Item 18. The disinfectant composition according to any of Items 3 to 17, wherein the component (E2) is glucose. Item 19. The disinfectant composition according to any of Items 3 to 18, wherein the component (E3) is propylene glycol. Item 20. The disinfectant composition according to any of Items 1-2 and 2 to 19, wherein the component (C) further comprises a non-halogenated metal compound (C2). Item 21. The disinfectant composition according to Item 20, wherein the component (C2) is selected from the group consisting of alkali metal hydroxides, alkaline earth metal hydroxides, alkali metal salts of organic acids, and alkaline earth metal salts of organic acids. Item 22. The disinfectant composition according to any one of Items 1 to 21, wherein the content of the component (A) is 60 to 95 v / v %. Item 23. The disinfectant composition according to any one of Items 1 to 22, wherein the content of the component (C) is 0.05 to 10 w / v %. Item 24. The disinfectant composition according to any one of Items 2 to 23, wherein the content of the component (D) is 0.05 to 10 w / v %. Item 25. The disinfectant composition according to any one of Items 3 to 24, wherein the content of the component (E) is 0.1 to 10 w / v %. Item 26. The disinfectant composition according to any one of Items 1 to 25, wherein the pH is 3.0 or less. Item 27. The disinfectant composition according to any one of Items 1 to 26, which is used for inactivating spore-forming bacteria. Item 28. The disinfectant composition according to Item 27, wherein the spore-forming bacteria is Clostridioides difficile. Item 29. Item 29. The disinfectant composition according to any one of Items 1 to 28, which is used for hand hygiene.

[0010] The disinfectant composition of the present invention is capable of inactivating spore-forming bacteria.

[0011] The results of a skin irritation test for the disinfectant compositions of the present invention (Examples 46 to 51), a commercially available mild hand disinfectant (Reference Example 1), and a commercially available highly irritating hand disinfectant (Reference Example 2) are shown. The results of a skin irritation test for the disinfectant compositions of the present invention (Examples 46 to 51), a commercially available mild hand disinfectant (Reference Example 1), and a commercially available highly irritating hand disinfectant (Reference Example 2) are shown.

[0012] The disinfectant composition of the present invention is characterized by comprising (A) ethanol (hereinafter also referred to as "component (A)"), (B) water (hereinafter also referred to as "component (B)"), and a predetermined compound selected from the group consisting of (C) (C1) halide salt (hereinafter also referred to as "component (C1)") and (C2) non-halogenated metal compound (hereinafter also referred to as "component (C2)") (hereinafter, components (C1) and (C2) are collectively referred to as "component (C)"), and is acidic. The disinfectant composition of the present invention is described in detail below. The disinfectant composition of the present invention is applicable to skin and is capable of inactivating spore-forming bacteria. In the present invention, inactivation of spore-forming bacteria means achieving a log reduction value (LR value) of spore-forming bacteria of 2.5 or more within 30 seconds.

[0013] [1. (A) Ethanol] The disinfectant composition of the present invention contains ethanol as component (A). The content of component (A) in the disinfectant composition of the present invention is, for example, 60 to 95 v / v %, and from the viewpoint of enhancing the inactivation ability of spore-forming bacteria, is preferably 65 to 90 v / v %, more preferably 70 to 85 v / v %, even more preferably 75 to 83 v / v %, and even more preferably 76.9 to 81.4 v / v %.

[0014] [2. (B) Water] The disinfectant composition of the present invention contains water as component (B). The content of component (B) in the disinfectant composition of the present invention is, for example, 5 to 40 v / v %, and from the viewpoint of enhancing the inactivation ability of spore-forming bacteria, is preferably 10 to 35 v / v %, more preferably 15 to 30 v / v %, even more preferably 17 to 25 v / v %, and even more preferably 19 to 23 v / v %.

[0015] [3. (C) Predetermined Compound (Halide Salt and / or Non-Halide Metal Compound)] The disinfectant composition of the present invention contains, as component (C), a predetermined compound selected from the group consisting of (C1) a halide salt and (C2) a non-halide metal compound. Of the components (C1) and (C2), the disinfectant composition of the present invention may contain, as component (C), only component (C1), only component (C2), or both component (C1) and component (C2).

[0016] [3-1. (C1) Halide Salt] The halide salt, which is the component (C1), refers to a compound composed of a halogen ion and a cation other than a hydrogen ion.

[0017] Examples of halogen elements constituting the halogen ions include fluorine, chlorine, bromine, and iodine, and from the viewpoint of enhancing the ability to inactivate spore-forming bacteria, chlorine, bromine, and iodine are preferred.

[0018] Other cations include metal ions, ammonium ions, aminium ions (ie, substituted ammonium ions), and pyridinium ions.

[0019] Metal elements constituting metal ions include alkali metals, alkaline earth metals, and amphoteric metals. Alkali metals include potassium and sodium. Alkaline earth metals include calcium and magnesium. Amphoteric metals include aluminum, tin, and zinc.

[0020] Specific examples of the aminium ion include ions represented by the following formulas (1) and (2), and specific examples of the pyridinium ion include an ion represented by the following formula (3). [In the formula, R 1 is an alkyl or alkenyl group having 6 to 18 carbon atoms, X is an aromatic ring, or an ester- or amide-linked group selected from —COO—, —CONH—, —OCO—, and —NHCO—, and R 2is an unsubstituted or substituted alkylene group having 1 to 6 carbon atoms when X is an ester bond group or an amide bond group, and is an unsubstituted or substituted alkylene group having 1 to 6 carbon atoms when X is an aromatic ring, or an alkylene oxide group having an average added mole number of 1 to 10 when X is an aromatic ring, and R 3 and R 4 are each independently an alkyl group or a hydroxyalkyl group having 1 to 3 carbon atoms, and R 5 is an alkylene group having 1 to 3 carbon atoms. Also, n1 is the number 0 or 1. R 6 ~R 9 At least one of these is an alkyl group having 8 to 18 carbon atoms, and the rest are alkyl groups or hydroxyalkyl groups having 1 to 3 carbon atoms. 10 is an alkyl or alkenyl group having 6 to 18 carbon atoms.

[0021] Among these other cations, from the viewpoint of enhancing the inactivation ability of spore-forming bacteria, metal ions are preferred, alkali metal ions and alkaline earth metal ions are more preferred, and potassium ions are particularly preferred.

[0022] In the halide salt, the above-mentioned halide ions and cations other than hydrogen ions can be combined arbitrarily.Furthermore, as the component (C1), these halide salts may be used singly or in combination of two or more.Preferred halide salts of the above-mentioned ions include alkali metal halide salts, alkaline earth metal halide salts, amphoteric metal halide salts, ammonium halide salts, and quaternary ammonium halide salts (preferably alkali metal halide salts, alkaline earth metal halide salts, ammonium halide salts, and quaternary ammonium halide salts), and more preferably alkali metal chlorides, alkaline earth metal chlorides, amphoteric metal chlorides, alkali metal bromides, alkali metal iodides, ammonium chloride, quaternary ammonium chlorides, and pyridinium chlorides (more preferably alkali metal chlorides, alkaline earth metal chlorides, alkali metal bromides, alkali metal iodides, ammonium chloride, and quaternary ammonium chlorides). More preferred examples of halide salts include potassium chloride, sodium chloride, calcium chloride, magnesium chloride, aluminum(III) chloride, tin(II) chloride, zinc chloride, potassium bromide, sodium bromide, potassium iodide, sodium iodide, ammonium chloride, benzalkonium chloride, benzethonium chloride, and cetylpyridinium chloride, and more preferred examples include potassium chloride, sodium chloride, calcium chloride, magnesium chloride, sodium bromide, potassium iodide, ammonium chloride, and benzalkonium chloride.From the viewpoint of compatibility between the versatility of halide salts and the inactivation ability of the disinfectant composition against spore-forming bacteria, potassium chloride is particularly preferred as the halide salt.

[0023] [3-2. (C2) Non-halogenated Metal Compound] The non-halogenated metal compound, which is the component (C2), refers to a compound composed of a non-halogen anion and a metal ion.

[0024] Non-halogen anions include hydroxide ions, organic acid ions, and phosphate ester ions. Organic acid ions are formed when the carboxyl group (-COOH) of an organic acid (i.e., an organic compound having a carboxyl group) is ionized (-COO -) ions. The "organic acid" of the organic acid ions is not particularly limited as long as it is an organic compound having a carboxyl group, and examples thereof include acetic acid, lactic acid, N-acylamino acid (preferably N-acetyltryptophan), fluorescein, etc. The "phosphate ester" of the phosphate ester ions includes a phosphate diester ion, and more preferably a higher alcohol ethylene oxide adduct phosphate ester ion shown in the following formula (4): [In the formula, R 11 and R 12 are each independently an alkyl or alkenyl group having 8 to 24 carbon atoms, and n2 and n3 are each independently an integer of 3 to 10.

[0025] Among these non-halogen anions, hydroxide ions and organic acid ions are preferred from the viewpoint of enhancing the ability to inactivate spore-forming bacteria.

[0026] Examples of the metal ions include alkali metal ions and alkaline earth metal ions, and preferably alkali metal ions, such as potassium ions and sodium ions.

[0027] In the non-halogenated metal compound, the above-mentioned halogen ions and cations other than hydrogen ions can be combined in any desired manner. As the component (C2), these non-halogenated metal compounds may be used singly or in combination of two or more. Non-halogenated metal compounds with preferred combinations of the above ions include sodium hydroxide, potassium hydroxide, potassium acetate, sodium lactate, sodium acetyltryptophan, sodium fluorescein, and polyoxyethylene oleyl ether sodium phosphate, and more preferably sodium hydroxide, potassium hydroxide, potassium acetate, and sodium lactate.

[0028] [3-3. Content] The content of component (C) in the disinfectant composition of the present invention, expressed as the total amount of components (C1) and (C2), may be, for example, 0.05 to 10 w / v%, preferably 0.1 to 7 w / v%, more preferably 0.5 to 5 w / v%, even more preferably 0.7 to 3 w / v%, even more preferably 0.8 to 2 w / v%, and particularly preferably 0.9 to 1.5 w / v%. The content of each of components (C1) and (C2) may be, for example, 0.05 to 10 w / v%, preferably 0.1 to 7 w / v%, more preferably 0.5 to 5 w / v%, even more preferably 0.7 to 3 w / v%, even more preferably 0.8 to 2 w / v%, and particularly preferably 0.9 to 1.5 w / v%.

[0029] [4. (D) Phenolic Compound and / or Phenylcarboxylic Acid Compound] The disinfectant composition of the present invention may contain a compound selected from the group consisting of (D) (D1) a specific phenolic compound (hereinafter also referred to as "component (D1)"), (D2) a specific phenylcarboxylic acid compound (hereinafter also referred to as "component (D2)"), and a specific substituted benzene (hereinafter also referred to as "component (D3)") (hereinafter, components (D1), (D2), and (D3) are collectively referred to as "component (D)"). The disinfectant composition of the present invention may contain, as component (D), only one of the three types of components, component (D1), component (D2), and component (D3), or may contain two or more types of components.

[0030] [4-1. (D1) Predetermined Phenol-Based Compound] The predetermined phenol-based compound, which is the component (D1), is a substituted or unsubstituted compound selected from the group consisting of phenol and phenoxy alcohol.

[0031] The substituted or unsubstituted phenol is a compound represented by the following formula (5), and the substituted or unsubstituted phenoxy alcohol is a compound represented by the following formula (6). [In the formula, R 13is hydrogen, halogen (preferably chlorine, bromine, or iodine, more preferably chlorine) [in this case, compound (5) or compound (6) is, respectively, R 13 as a halogen substituent], or an alkyl group having 1 to 6 carbon atoms (preferably 1 to 4 carbon atoms) (specifically, a methyl group, an ethyl group, an n-propyl group, an isopropyl group, an n-butyl group, a sec-butyl group, a tert-butyl group, an n-pentyl group, an isopentyl group, a sec-pentyl group, a 3-pentyl group, a tert-pentyl group, an n-hexyl group, an isohexyl group, a sec-hexyl group, a 3-hexyl group, or a tert-hexyl group) [in this case, compound (5) or compound (6) is a substituted phenol or a substituted phenoxy alcohol having R 13 as an alkyl substituent], and n4 is an integer of 1 to 6 (preferably 1 to 4, more preferably 1 to 3, and even more preferably 1 to 2). 13 is a substituent, R 13 The number of is 1 to 3, and R 13 When the number of R is 2 or 3, each R 13 may be the same as or different from each other.

[0032] Specific examples of the compound represented by formula (5) include phenol, cresol, hydroquinone, chlorocresol, and dibutylhydroxytoluene.Specific examples of the compound represented by formula (6) include 2-phenoxyethanol, 3-phenoxy-1-propanol, and ethylene glycol mono(4-chlorophenyl) ether.

[0033] As the component (D1), one of these specified phenolic compounds may be used alone, or two or more may be used in combination.

[0034] Preferable examples of the compound represented by the formula (5) include those compounds represented by the formula (5), 13 is hydrogen or a methyl group, and R 13 is a methyl group, R 13More preferred examples include compounds in which the number of R 13 A preferred example of the compound represented by the formula (6) is a phenol in which R 13 is hydrogen or a methyl group, and R 13 is a methyl group, R 13 and n4 is an integer of 1 to 6. More preferred examples include compounds in which R 13 is hydrogen and n4 is an integer of 1 to 6, and more preferred examples include 2-phenoxyethanol and 3-phenoxy-1-propanol.

[0035] Among the components (D1), a particularly preferred example from the viewpoint of enhancing the ability to inactivate spore-forming bacteria is 2-phenoxyethanol, which is preferred because of its low toxicity and low risk of environmental pollution, and also because it is a liquid and therefore does not precipitate even when the disinfectant composition dries after external use.

[0036] [4-2. (D2) Prescribed Phenylcarboxylic Acid Compound] The prescribed phenylcarboxylic acid compound, component (D2), is a compound containing a substituted or unsubstituted phenyl group and an H-type, salt-type, or esterified carboxyl group.

[0037] The predetermined phenylcarboxylic acid compound is a compound represented by the following formula (7): [In the formula, R 14 is hydrogen [in this case -COR 14 is an H-type carboxyl group], an alkali metal ion (preferably potassium or sodium, more preferably sodium) [in this case, -COR 14 is a salt-type carboxyl group], an alkyl group having 1 to 4 carbon atoms (preferably 1 to 3, more preferably 1 to 2) and having or not having a hydroxyl group as a substituent (preferably a methyl group, ethyl group, n-propyl group, isopropyl group, n-butyl group, sec-butyl group, tert-butyl group, hydroxyethyl group, 1-hydroxyethyl group, 2-hydroxyethyl group, or 3-hydroxypropyl group) [in this case, -COR14 is an esterified carboxyl group], or a substituted or unsubstituted aryl group having 6 to 14 carbon atoms (preferably a phenyl group, a methyl-substituted phenyl group (preferably a tolyl group or a xylyl group), a naphthyl group, or an anthryl group, more preferably a phenyl group) or an aralkyl group (preferably a benzyl group, a 1-phenylethyl group, a 2-phenylethyl group, a 1-phenylpropyl group, a naphthylmethyl group, a 1-naphthylethyl group, or a 1-naphthylpropyl group, more preferably a benzyl group) [in this case, —COR 14 is an esterified carboxyl group; and R 15 is an unsubstituted or substituted alkylene group having 1 to 6 carbon atoms (preferably 1 to 4, more preferably 1 to 3) and having a hydroxyl group as a substituent (preferably a methylene group, ethylene group, n-propylene group, isopropylene group, n-butylene group, isobutylene group, sec-butylene group, tert-butylene group, n-pentylene group, n-hexylene group, hydroxymethylene group, hydroxyethylene group, or hydroxypropylene group, more preferably a methylene group, ethylene group, n-propylene group, hydroxymethylene group, or hydroxyethylene group), and R 16 is hydrogen or a hydroxyl group, and R 17 represents hydrogen, an alkyl group having 1 to 6 carbon atoms (preferably 1 to 4, more preferably 1 to 3, even more preferably 1 to 2, and particularly preferably 1) (specifically, a methyl group, an ethyl group, an n-propyl group, an isopropyl group, an n-butyl group, a sec-butyl group, a tert-butyl group, an n-pentyl group, an isopentyl group, a sec-pentyl group, a 3-pentyl group, a tert-pentyl group, an n-hexyl group, an isohexyl group, a sec-hexyl group, a 3-hexyl group, or a tert-hexyl group), a hydroxyl group, an aldehyde group, or an amino group [R 17 is other than hydrogen, compound (7) is 17 and an H-type, salt-type, or esterified carboxyl group], and n5 is a number of 0 or 1. 17 is a substituent, R 17 The number of is 1 to 2 (preferably 1), and R 17 When the number of R is two, each R17 may be the same as or different from each other.

[0038] Specific examples of the predetermined phenylcarboxylic acid compound represented by the above formula (7) include salicylic acid, sodium salicylate, methyl salicylate, phenyl salicylate, 2-hydroxyethyl salicylate, gentisic acid, benzoic acid, sodium benzoate, benzyl benzoate, benzyl benzoate, ethyl aminobenzoate, 4-methylbenzoic acid, 2-aminobenzoic acid, 4-formylbenzoic acid, 4-aminophenylacetic acid, 2-hydroxyphenylacetic acid, sodium 2-phenylbutyrate, and mandelic acid.

[0039] As the component (D2), one of these specified phenylcarboxylic acid compounds may be used alone, or two or more may be used in combination.

[0040] More preferred examples of the predetermined phenylcarboxylic acid compound are salicylic acid represented by the following formula (7-1) or a salt or derivative thereof, and benzoic acid represented by the following formula (7-2) or a salt or derivative thereof. [In formula R 14 is as described in the above formula (7), and R in formula (7-1) 14 is preferably hydrogen, an alkali metal ion (preferably potassium or sodium, more preferably sodium), or an alkyl group having 1 to 4 carbon atoms (preferably 1 to 3, more preferably 1 to 2) which has or is not substituted with the above-mentioned hydroxyl group as a substituent, and R in formula (7-2) 14 is preferably hydrogen or the above-mentioned unsubstituted alkyl group having 1 to 4 carbon atoms (preferably 1 to 3, more preferably 1 to 2), and more preferably hydrogen.

[0041] More preferred examples of salicylic acid or a salt or derivative thereof represented by the above formula (7-1) are salicylic acid, methyl salicylate, and 2-hydroxyethyl salicylate, and a more preferred example of benzoic acid or a salt or derivative thereof represented by the above formula (7-2) is benzoic acid.

[0042] Among the components (D2), a particularly preferred example from the viewpoint of enhancing the ability to inactivate spore-forming bacteria is 2-hydroxyethyl salicylate, which is preferred because of its low toxicity and low risk of environmental pollution, and also because it is a liquid and therefore does not precipitate even when the disinfectant composition dries after external use.

[0043] [4-3. (D3) Substituted Benzene] The predetermined substituted benzene component (D3) is a compound represented by the following formula (8). [In the formula, R 18 is an alkyl group having 1 to 4 carbon atoms (preferably 1 to 3, more preferably 1 to 2) which has a hydroxyl group as a substituent or is unsubstituted (preferably a methyl group, an ethyl group, an n-propyl group, an isopropyl group, an n-butyl group, a sec-butyl group, a tert-butyl group, a hydroxyethyl group, a 1-hydroxyethyl group, a 2-hydroxyethyl group, or a 3-hydroxypropyl group), a halogen (preferably chlorine, bromine, or iodine, more preferably chlorine), or an amino group; R 18 The number of R is 1 to 4 (preferably 1 to 3, more preferably 1 to 2, and even more preferably 1), 18 When the number of R is two or more, each R 18 may be the same as or different from each other.

[0044] Specific examples of the predetermined substituted benzene represented by the above formula (8) include toluene, chlorobenzene, aniline, benzyl alcohol, and phenylethyl alcohol.

[0045] As the component (D3), one of these predetermined substituted benzenes may be used alone, or two or more may be used in combination.

[0046] Preferable examples of the compound represented by the formula (8) include those compounds represented by the formula (8) in which R 18 is an alkyl group having 1 to 4 carbon atoms and having a hydroxyl group as a substituent, and R 18 and compounds in which the number of is 1, preferably benzyl alcohol and phenylethyl alcohol, more preferably benzyl alcohol.

[0047] [4-4. Content] The content of component (D) in the disinfectant composition of the present invention, expressed as the total amount of components (D1), (D2), and (D3), may be, for example, 0.05 to 10 w / v%, preferably 0.1 to 7 w / v%, more preferably 0.5 to 5 w / v%, even more preferably 0.7 to 3 w / v%, even more preferably 0.8 to 2.5 w / v%, and particularly preferably 0.9 to 1.5 w / v%. Furthermore, the content of each of components (D1), (D2), and (D3) may be, for example, 0.05 to 10 w / v%, preferably 0.1 to 7 w / v%, more preferably 0.5 to 5 w / v%, even more preferably 0.7 to 3 w / v%, even more preferably 0.8 to 2.5 w / v%, and particularly preferably 0.9 to 1.5 w / v%.

[0048] [5. Sugar Alcohol, Monosaccharide, and / or Polyhydric Alcohol] From the viewpoint of enhancing the inactivation ability of spore-forming bacteria, the disinfectant composition of the present invention may contain a compound selected from the group consisting of (E) and (E1) sugar alcohols (hereinafter also referred to as "(E1) component"), (E2) monosaccharides (hereinafter also referred to as "(E2) component"), and (E3) polyhydric alcohols (hereinafter also referred to as "(E3) component") (hereinafter, the (E1) component, the (E2) component, and the (E3) component are collectively referred to as "(E) component"). The disinfectant composition of the present invention may contain, as the component (E), only one type of component out of the three types of components, the (E1), the (E2), and the (E3) component, or may contain two or more types of components.

[0049] [5-1. (E1) Sugar Alcohol] The sugar alcohol (E1) is not particularly limited, but examples thereof include sorbitol, xylitol, erythritol, mannitol, maltitol, and lactitol. As the (E1) component, one of these sugar alcohols may be used alone, or two or more may be used in combination. Among these sugar alcohols, sorbitol and xylitol are preferred.

[0050] [5-2. (E2) Monosaccharides] The monosaccharides (E2) are not particularly limited, but examples thereof include glucose, fructose, galactose, mannose, ribose, xylose, and arabinose. As the (E2) component, one of these monosaccharides may be used alone, or two or more may be used in combination. Among these monosaccharides, glucose is preferred.

[0051] [5-3. (E3) Polyhydric Alcohol] The polyhydric alcohol (E3) is not particularly limited (however, the component (E3) does not include the components (E1) and (E2) described above), but examples include dihydric alcohols such as ethylene glycol, polyethylene glycol, propylene glycol, 1,3-butylene glycol, dipropylene glycol, and 3-methyl-1,3-butanediol, as well as glycerin, diglycerin, and polyglycerin. As the component (E3), one of these polyhydric alcohols may be used alone, or two or more may be used in combination. Of these polyhydric alcohols, dihydric alcohols are preferred, with ethylene glycol, propylene glycol, 1,3-butylene glycol, and 3-methyl-1,3-butanediol being more preferred, and propylene glycol being even more preferred.

[0052] [5-4. Content] The content of component (E) in the disinfectant composition of the present invention is, for example, 0.1 to 10 w / v%, preferably 0.5 to 5 w / v%, more preferably 0.9 to 4 w / v%, even more preferably 1.4 to 3 w / v%, and even more preferably 1.9 to 2.5 w / v% in terms of the total amount of components (E1), (E2), and (E3). The content of each of components (E1), (E2), and (E3) may be, for example, 0.1 to 10 w / v%, preferably 0.5 to 5 w / v%, more preferably 0.9 to 4 w / v%, even more preferably 1.4 to 3 w / v%, and even more preferably 1.9 to 2.5 w / v%.

[0053] [6. pH Adjuster] The disinfectant composition of the present invention is acidic. Specific examples of the pH of the disinfectant composition of the present invention include a pH of 3.0 or less, preferably 1.5 to 3.0. From the viewpoint of enhancing the inactivation ability of spore-forming bacteria, the pH is preferably 1.8 to 2.5, more preferably 1.8 to 2.3, even more preferably 1.8 to 2.2, even more preferably 1.8 to 2.1, and particularly preferably 1.8 to 2.0 or 1.9 to 2.0. In the present invention, the pH of the disinfectant composition is measured using a glass electrode according to the pH measurement method of "General Test Method 2.54" of the Japanese Pharmacopoeia, 18th Edition, and is obtained as the pH at 20°C.

[0054] The disinfectant composition of the present invention contains a pH adjuster to adjust the composition to an acidic state. The pH adjuster contains at least an acid. Examples of the acid include hydrogen chloride and trifluoroacetic acid. These acids may be used alone or in combination of two or more.

[0055] [7. Other Components] The disinfectant composition of the present invention may or may not contain any other components in addition to the above-mentioned component (A), component (B), component (C), pH adjuster, and component (D) and / or component (E) blended as needed, as long as the effects of the present invention are not impaired. Such other components, which may or may not be contained, can be appropriately selected by those skilled in the art depending on the application and / or formulation of the disinfectant composition of the present invention. Specifically, other components include oils such as fatty acid esters such as glycerin triisooctanoate, isopropyl palmitate, isopropyl myristate, and olive oil; nonionic surfactants such as lauric acid diethanolamide, coconut oil fatty acid diethanolamide, coconut oil fatty acid monoethanolamide, lauric acid monoisopropanolamide, oleic acid monoisopropanolamide, palm kernel oil fatty acid diethanolamide, and polyoxyethylene coconut oil fatty acid monoethanolamide; cationic surfactants such as lauryl dimethylamine oxide and alkyl dimethylamine oxide. thickening agents such as carboxymethylcellulose, hydroxypropylcellulose, pectin, chitosan, chitin, xanthan gum, carboxyvinyl polymer, povidone, polyvinyl alcohol, etc.; anti-inflammatory agents such as glycyrrhetinic acid, dipotassium glycyrrhizinate, stearyl glycyrrhetinate, allantoin, azulene, licorice extract, tocopherol acetate, aloe extract, etc.; skin protectants such as algae extract, betaine, Camellia sinensis leaf extract, cerebroside, dimethicone, glucuronolactone, glycerin, kaolin, lanolin, malt extract, talc, etc. When these other ingredients are contained, the other ingredients may be used alone or in combination of two or more.

[0056] [8. Dosage Form] The dosage form of the disinfectant composition of the present invention is not particularly limited as long as it can be used as a rubbing agent. Specific dosage forms include liquid, cream, foam, gel, ointment, etc., and preferably liquid.

[0057] [9. Production Method] The method for producing the disinfectant composition of the present invention is not particularly limited. As an example, the disinfectant composition of the present invention can be produced by dissolving component (C) in component (B), adding and mixing component (A), further adding and mixing component (D), and adjusting the solution to acidic. In this case, component (B) may be further added after adding component (D) and / or after adjusting the solution to acidic.

[0058] [10. Uses] The disinfectant composition of the present invention is effective in inactivating spore-forming bacteria. Therefore, the disinfectant composition of the present invention can be used for inactivating spore-forming bacteria.

[0059] Inactivation of spore-forming bacteria means that the spore-forming bacteria (initial number of bacteria: 2 × 10) are inactivated within 30 seconds (for example, 10 to 30 seconds) of contact between the spore-forming bacteria and the disinfectant composition. 7 This means that the log reduction value (LR value) of the spore-forming bacteria (CFU / mL) is 2.5 or more (e.g., 2.5 to 6). The LR value within 30 seconds is preferably 3 to 6, more preferably 3.5 to 6, and even more preferably 4 to 6. The contact time between the spore-forming bacteria and the disinfectant composition required for the LR value to reach 2.5 or more (e.g., 2.5 to 6) is preferably 10 to 20 seconds, more preferably 10 to 15 seconds, 12 to 35 seconds, or 14 to 15 seconds.

[0060] The spore-forming bacteria are not particularly limited, but preferably include microorganisms of the genus Clostridioides, and more preferably Clostridioides difficile.

[0061] The disinfectant composition of the present invention is preferably applied to the skin. More preferably, the disinfectant composition of the present invention is used as a rubbing agent. Even more preferably, the disinfectant composition of the present invention is used for hand hygiene. Particularly preferably, the disinfectant composition of the present invention is used for hand hygiene by medical workers to prevent hospital-acquired infections.

[0062] The present invention will be described in more detail below with reference to examples, etc. However, the present invention is not limited to the following embodiments.

[0063] [Test Example 1] Sporicidal test [1] Test materials and methods [1.1] Test bacteria Clostridioides difficile (ATCC 43593, Microbiologics, Inc.) was used.

[0064] [1.2] Reagents and media (1) Diluent: Polysorbate 80 (product code: 166-21595, Fujifilm Wako Pure Chemical Corporation) 200 g, soybean lecithin (product code: 12128, Nisshin Oillio Group Co., Ltd.) 23.34 g, anhydrous sodium phosphate monobasic (product code: 048-29665, Fujifilm Wako Pure Chemical Corporation) 20.2 g, potassium dihydrogen phosphate (product code: 136-14485, Fujifilm Wako Pure Chemical Corporation) 0.80 g, sodium thiosulfate hydrate (product code: 190-13845, Fujifilm Wako Pure Chemical Corporation) 10.0 g, Triton X-100 (product code: 169-21105, Fujifilm Wako Pure Chemical Corporation) 2.0 mL, Tamol 20.0 g of NN8906 (product number: 50263222, BASF Japan Ltd.) was added to 1600 mL of distilled water and heated and stirred until dissolved. After dissolution, the pH was adjusted to 7.8-7.9, and distilled water was added until the total volume reached 2000 mL. This was then sterilized by high-pressure steam (121°C, 20 minutes).

[0065] (2) 50 w / v% Nycodenz Nycodenz AG (product number: AXS-1002424, Abbott Diagnostics Technologies AS) (50 g) was mixed with 100 mL of purified water and stirred. The mixture was then sterilized under high pressure (121°C, 20 minutes).

[0066] (3) BHIS Plate: 52 g of Brain Heart Infusion Agar (product number: 211065, Becton Dickinson), 5 g of Bacto Yeast Extract (product number: 212750, Becton Dickinson), and 1 g of L-cysteine ​​hydrochloride monohydrate (product number: 030-24102, Fujifilm Wako Pure Chemical Corporation) were mixed with 1000 mL of purified water and stirred. This mixture was sterilized by high-pressure steam (121°C, 15 minutes), and approximately 20 mL was dispensed into a Petri dish and allowed to solidify.

[0067] (4) Modified GAM agar plate (mGAM plate) Acudia TM 1000 mL of purified water was added to 56.7 g of modified GAM agar medium (product number: 05426, Shimadzu Diagnostics Co., Ltd.) and stirred. This was then sterilized by high-pressure steam (115°C, 15 minutes), and approximately 20 mL of the mixture was dispensed into petri dishes and allowed to solidify.

[0068] (5) Modified GAM agar medium (mGAMT agar medium) Acudia TM 56.7 g of modified GAM agar medium (product number: 05426, Shimadzu Diagnostics Co., Ltd.) and 1.0 g of sodium taurocholate (product code: T0808, Tokyo Chemical Industry Co., Ltd.) were added to 1000 mL of purified water and stirred. This was then sterilized by high-pressure steam (115°C, 15 minutes). The mixture was then kept at 48°C until use.

[0069] (6) Preparation of Purified Spore Solution: C. difficile ATCC 43593 bacteria grown on mGAM plates in an anaerobic chamber were harvested and suspended in saline to prepare a McFarland No. 1 suspension. This suspension was diluted 1 / 2000 with saline, and 100 μL was smeared onto a BHIS plate. Anaerobic incubation (35°C) was performed for 10 days or more to allow spore formation. The spore-forming bacteria were recovered from the BHIS plate in 10 mL of distilled water and heat-treated (75°C, 20 min). After cooling, the suspension was centrifuged (4500 × g, 4°C, 10 min), and the supernatant was removed. The pellet was suspended in 3 mL of ice-cold distilled water and gently added to 5 mL of 50 w / v% Nycodenz. The suspension was then centrifuged (4500 × g, 4°C, 10 min). The upper layer was removed, and the pellet was recovered in ice-cold distilled water. The spores were washed three times with ice-cold distilled water and suspended in an appropriate amount of distilled water to obtain a purified spore solution, which was then stored at 4°C until use.

[0070] [2] Test Samples (Disinfectant Compositions of Examples or Comparative Examples) [2.1] Preparation of Test Samples The disinfectant compositions shown in Tables 1 to 9 were prepared. Specifically, [i] component (C) and component (E) were dissolved in component (B), [ii] component (A) or isopropanol was added, [iii] component (D) was added, [iv] component (B) was added until all added components were dissolved, [v] a pH adjuster was added, and [vi] component (B) was added to adjust the liquid volume. [2.2] pH Measurement of Test Samples The pH was measured using a glass electrode according to the pH measurement method "General Test Method 2.54" of the 18th Edition of the Japanese Pharmacopoeia. The pH was measured at 20°C.

[0071] [3] Sporicidal test: Dilute the purified spore solution with distilled water to 2 x 10 7 A suspension of approximately CFU / mL was prepared, which was used as the test bacterial solution.

[0072] 1 mL of the test sample (the disinfectant composition of the Example or Comparative Example, immediately after preparation) was mixed with 10 μL of the test bacteria solution to obtain a reaction solution. After the reaction solution was left to stand at room temperature (23°C) for a predetermined time (15 seconds, 20 seconds, or 30 seconds), 0.25 mL of the reaction solution was added to 4.75 mL of the dilution solution, and 10 1 A 10-fold dilution was obtained. 1 0.3 mL of the diluted solution was added to 2.7 mL of the diluted solution to make a 10-fold dilution. 1 ~10 3 A total of three dilutions (up to 10 times diluted solution) were prepared. 1 ~10 3 One mL of each 2x diluted solution was dispensed into a petri dish, and approximately 15 mL of mGAMT agar medium stored at approximately 48°C was added to prepare pour plates. The pour plates were anaerobically cultured until colony counting became possible, and the number of colonies was counted. A control (for measuring initial viable cell count) was prepared by treating the plates in the same manner using distilled water instead of the test sample.

[0073] The number of colonies obtained was multiplied by the dilution factor to calculate the number of viable bacteria. The colony count from the pour plate that yielded 30 to 300 colonies was used. If the number of colonies was less than 30 at all dilution factors, the colony count from the lowest dilution factor was used, and if the number of colonies was 300 or more at all dilution factors, the colony count from the highest dilution factor was used. The log reduction value (LR value) was calculated using the following formula.

[0074] The LR value was rounded to three decimal places. If the number of colonies after the test substance was applied was 0, the LR was expressed as "> [initial viable count (common logarithm) - 1]" with an inequality sign. The higher the LR value, the greater the inactivation effect on spore-forming bacteria. The results are shown in Tables 1 to 9. In the tables, " / " indicates that data was not available.

[0075]

[0076]

[0077]

[0078]

[0079]

[0080]

[0081]

[0082]

[0083]

[0084] As shown in Tables 1 to 9, the disinfectant compositions of Examples 1 to 45 were effective in inactivating spore-forming bacteria.

[0085] Test Example 2: Skin Irritation Test The disinfectant compositions shown in the table below were prepared. The disinfectant compositions shown in the table below were effective in inactivating spore-forming bacteria. Also, a commercially available mild hand disinfectant (containing 0.2 g of chlorhexidine gluconate as the active ingredient, N-cocoyl-L-arginine ethyl ester DL-pyrrolidone carboxylate, concentrated glycerin, glycerin triisooctanoate, methylpolysiloxane, lactic acid, and ethanol as additives, with the balance being water, per 100 mL) was prepared. Also, a commercially available highly irritating hand disinfectant (containing 0.2 g of benzalkonium chloride as the active ingredient, and additives such as propylene glycol, isopropyl myristate, and ethanol, with the balance being water, per 100 mL) was prepared.

[0086]

[0087] 0.1 mL of the disinfectant composition of Examples 46 to 51 or Reference Examples 1 and 2 was applied to the skin of rabbits. Application was performed once daily for 10 days (Monday through Friday of the first week and Monday through Friday of the second week) at eight locations on the rabbit's skin. Erythema and crust formation, as well as edema formation, were evaluated visually and averaged based on the criteria of Draize et al. (Draize JH, Woodard G, Calvery HO. Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes. J Pharmacol Exp Ther 1944; 82: 377-390.) as shown in the table below. The results are shown in Figures 1 and 2.

[0088]

[0089] As shown in Figures 1 and 2, the disinfectant compositions of Examples 46 to 51 all had an average rating of mildness of less than 1. The degree of mildness provided by the disinfectant compositions of Examples 46 to 51 was much milder than that of the commercially available highly irritating hand disinfectant of Reference Example 2, and was equivalent to that of the commercially available mild hand disinfectant of Reference Example 1.

[0090] [Test Example 3] Sporicidal test A sporicidal test was conducted in the same manner as in Test Example 1, except that the disinfectant compositions shown in Tables 12 and 13 were prepared. The LR value obtained when the reaction solution obtained by mixing the disinfectant composition of Example 1 with a test bacterial solution was allowed to stand for 20 seconds ("LR value of Example 1 (20 seconds)") was subtracted from the LR value of each disinfectant composition to obtain a value ("LR difference"). The results are shown in Tables 12 and 13. A positive LR difference indicates a higher inactivation effect on spore-forming bacteria than the disinfectant composition of Example 1. Furthermore, a larger LR difference indicates a higher inactivation effect on spore-forming bacteria.

[0091] Furthermore, the disinfectant compositions shown in Table 13 were stored at 60°C for 2 weeks, and the LR difference was calculated in the same manner as above. Furthermore, the LR value of the disinfectant composition immediately after preparation minus the LR value of the disinfectant composition after 2 weeks of storage at 60°C was calculated as the "instability score." A smaller instability score indicates higher stability over time. The results are shown in Table 13.

[0092]

[0093]

[0094] As shown in Tables 12 and 13, the disinfectant compositions of Examples 1, 29 to 31, 33, and 52 to 59 were effective in inactivating spore-forming bacteria.

[0095] Furthermore, in comparison with Example 1, an improvement in the inactivation effect of spore-forming bacteria was observed in Examples 52 to 56, and the improvement in the inactivation effect of spore-forming bacteria in Examples 52 to 54 was particularly remarkable. Specifically, in comparison with Example 1, the improvement in the inactivation effect of spore-forming bacteria in Example 55 (disinfectant composition to which 0.1% hydrogen peroxide was added) was only 0.22 in the LR value (30 seconds) (1.09 - 0.87 = 0.22 from Table 12). 0.22 = 1.7 times.) In contrast, the improvement in the inactivation effect of spore-forming bacteria in Example 53 (the disinfectant composition to which 0.1% of the (D1) component was added) was 0.69 in the LR value (30 seconds) (1.56 - 0.87 = 0.69 from Table 12. The number of killed spores was 10 0.69= 4.9 times.) The improvement in the inactivation effect of spore-forming bacteria by Example 54 (the disinfectant composition to which 0.05% of the (D2) component was added) was 0.94 in the LR value (30 seconds) (1.81 - 0.87 = 0.94 from Table 12. The number of killed spores was 10 0.94 = 8.7 times.)

[0096] Furthermore, the addition of the (D) component improved stability over time, as shown by the instability scores of Examples 57 to 59, 29 to 31, and 33 compared with Example 1. In addition, as shown by the LR difference of Example 57 compared with Examples 29 and 30, when 2-phenoxyethanol was selected among the (D1) components, the improvement in the inactivation effect of spore-forming bacteria was significant, and as shown by the LR difference of Example 58 compared with Examples 31, 59, and 33, when 2-hydroxyethyl salicylate was selected among the (D2) components, the improvement in the inactivation effect of spore-forming bacteria was significant.

Claims

1. A disinfectant composition comprising (A) ethanol, (B) water, and (C) a specified compound, wherein the component (C) is (C1) potassium chloride, and the composition is acidic.

2. The disinfectant composition of claim 1, further comprising a component (D) selected from the group consisting of the following compounds: (D1) a substituted or unsubstituted phenolic compound selected from the group consisting of phenol and phenoxy alcohol, (D2) a phenylcarboxylic acid compound containing a substituted or unsubstituted phenyl group and an H-type, salt-type, or esterified carboxyl group, and (D3) a benzene having a substituent other than a carboxyl group.

3. The disinfectant composition of claim 1 or 2, further comprising a component selected from the group consisting of (E) (E1) sugar alcohols, (E2) monosaccharides, and (E3) polyhydric alcohols.

4. The component (D1) is a substituted or unsubstituted phenol represented by the following formula (5) and a substituted or unsubstituted phenoxy alcohol represented by the following formula (6): [In formula (5) and formula (6), R 13 is hydrogen, halogen, or an alkyl group having 1 to 6 carbon atoms, n4 is an integer of 1 to 6, and R 13 is other than hydrogen, R 13 The number of is 1 to 3, and R 13 When the number of R is 2 or 3, each R 13 The disinfectant composition of claim 2, wherein the hydroxyl groups are selected from the group consisting of:

5. In the formula (5) and formula (6), R 13 is hydrogen or a methyl group, and R 13 is a methyl group, R 13 The disinfectant composition according to claim 4, wherein the number of is 1 and n4 is an integer of 1 to 6.

6. The disinfectant composition of claim 2, wherein the component (D1) is selected from the group consisting of phenol, 2-phenoxyethanol, and 3-phenoxy-1-propanol.

7. The component (D2) is represented by the following formula (7): [In formula (7), R 14 is a hydrogen atom, an alkali metal ion, an alkyl group having 1 to 4 carbon atoms, which may be substituted or unsubstituted with a hydroxyl group, or a substituted or unsubstituted aryl group or aralkyl group having 6 to 14 carbon atoms; R 15 is an unsubstituted or substituted alkylene group having 1 to 6 carbon atoms and a hydroxyl group as a substituent, and R 16 is hydrogen or a hydroxyl group, and R 17 is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, a hydroxyl group, an aldehyde group, or an amino group, n5 is a number of 0 or 1, and R 17 is other than hydrogen, R 17 The number of is 1 to 2, and R 17 When the number of R is two, each R 17 The disinfectant composition according to claim 2, wherein the compound is represented by the formula:

8. The component (D2) is a salicylic acid or a salt or derivative thereof represented by the following formula (7-1), and a benzoic acid or a salt or derivative thereof represented by the following formula (7-2): [In formula (7-1), R 14 represents a hydrogen atom, an alkali metal ion, or an alkyl group having 1 to 4 carbon atoms, which may be substituted with a hydroxyl group or may be unsubstituted, and in formula (7-2), R 14 is hydrogen, an alkali metal ion, or an unsubstituted alkyl group having 1 to 4 carbon atoms.

9. The disinfectant composition of claim 2, wherein the component (D2) is selected from the group consisting of salicylic acid, methyl salicylate, 2-hydroxyethyl salicylate, and benzoic acid.

10. The disinfectant composition according to claim 2, wherein the component (D) is the component (D2), and the component (D2) is 2-hydroxyethyl salicylate and / or methyl salicylate.

11. The component (D3) is represented by the following formula (8): [In formula (8), R 18 is an alkyl group having 1 to 4 carbon atoms, halogen, or amino group, which may or may not have a hydroxyl group as a substituent; R 18 The number of is 1 to 4, and R 18 When the number of R is two or more, each R 18 The disinfectant composition according to claim 2, wherein the compound is represented by the formula:

12. In the formula (8), R 18 is an alkyl group having 1 to 4 carbon atoms and having a hydroxyl group as a substituent, and R 18 The disinfectant composition of claim 11, wherein the number of is 1.

13. The disinfectant composition of claim 2, wherein the component (D3) is benzyl alcohol.

14. The disinfectant composition according to claim 3, wherein the component (E1) is sorbitol and / or xylitol.

15. The disinfectant composition according to claim 3, wherein the component (E2) is glucose.

16. The disinfectant composition of claim 3, wherein the component (E3) is propylene glycol.

17. The disinfectant composition according to claim 1 or 2, wherein the component (C) further comprises (C2) a non-halogenated metal compound.

18. The disinfectant composition of claim 17, wherein the component (C2) is selected from the group consisting of alkali metal hydroxides, alkaline earth metal hydroxides, alkali metal salts of organic acids, and alkaline earth metal salts of organic acids.

19. A disinfectant composition according to claim 1 or 2, wherein the content of component (A) is 60 to 95 v / v %.

20. A disinfectant composition according to claim 1 or 2, wherein the content of component (C) is 0.05 to 10 w / v %.

21. The disinfectant composition according to claim 2, wherein the content of component (D) is 0.05 to 10 w / v %.

22. The disinfectant composition according to claim 3, wherein the content of component (E) is 0.1 to 10 w / v %.

23. The disinfectant composition of claim 1 or 2, having a pH of 3.0 or less.

24. A disinfectant composition according to claim 1 or 2, used for inactivating spore-forming bacteria.

25. The disinfectant composition of claim 24, wherein the spore-forming bacterium is Clostridioides difficile.

26. A disinfectant composition according to claim 1 or 2, used for hand hygiene.

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