Hangover relief agent

Abstract

A hangover relief agent is disclosed. Provided according to an aspect of the present invention is a hangover relief agent comprising 100 to 200 parts by weight of an Indian gooseberry extract, 100 to 150 parts by weight of purified glucose, and 40 to 60 parts by weight of barley sprout powder.

Description

hangover cure

[0001] The present invention relates to a hangover cure.

[0002]

[0003] Modern people experience various stresses in their daily lives, and to escape from this stress, they resort to sleeping, overeating, exercising, smoking, drinking, etc.

[0004] Drinking is the most common way to relieve stress, but it is common to suffer from hangover symptoms such as a heavy head, headache, or stomach upset after drinking.

[0005] A hangover is a feeling of discomfort, headache, and decreased mental and physical functioning that persists for one or two days after drinking. Symptoms of a hangover after drinking include fever, thirst, headache, abdominal pain, indigestion, nausea, vomiting, and diarrhea.

[0006] Three known causes of hangovers are serotonin, calcium, and acetaldehyde. Alcohol increases the production of the neurotransmitter serotonin, dilating blood vessels and stimulating pain points in blood vessel walls, leading to hangover symptoms like migraines.

[0007] Alcohol also alters our body's calcium metabolism. A temporary calcium deficiency can lead to feelings of discomfort, anxiety, and tension, worsening the overall state of mind and body. Furthermore, acetaldehyde, a toxin that damages our cells, is a byproduct of the liver enzymes' attempt to rapidly reduce alcohol levels by breaking down alcohol. It is carried through the bloodstream and enters the brain, causing headaches and stomachaches.

[0008] (Patent Document 0001) Republic of Korea Patent Publication No. 10-2437419 (20220829)

[0009]

[0010] The present invention provides a hangover remedy comprising an Indian gooseberry extract, refined glucose, and barley sprout powder, which can reduce the concentration of acetaldehyde in the blood and alleviate hangover symptoms when taken by a drinker.

[0011]

[0012] According to one aspect of the present invention, a hangover remedy is provided comprising 100 to 200 parts by weight of Indian gooseberry extract, 100 to 150 parts by weight of refined glucose, and 40 to 60 parts by weight of barley sprout powder.

[0013] The hangover remedy may further comprise 90 to 150 parts by weight of fruit concentrate.

[0014] Fruit concentrates may include grape concentrate, pear concentrate, and apple concentrate.

[0015] The fruit concentrate may comprise 30 to 50 parts by weight of grape concentrate, 30 to 50 parts by weight of pear concentrate and 30 to 50 parts by weight of apple concentrate.

[0016] The hangover remedy may further contain 30 to 50 parts by weight of orange extract.

[0017] The hangover remedy may further contain 10 to 30 parts by weight of ginger extract.

[0018] The hangover remedy may further contain 10 to 20 parts by weight of extract of the fruit of the Chinese juniper tree.

[0019] The hangover remedy may further contain 2 to 4 parts by weight of vitamin C.

[0020] The hangover remedy may further contain 2 to 4 parts by weight of amino acid reversible.

[0021] Hangover remedies may further contain magnesium stearate.

[0022]

[0023] According to the present invention, the composition comprises Indian gooseberry extract, refined glucose and barley sprout powder, and can reduce the concentration of acetaldehyde in the blood and reduce hangover symptoms when taken by a drinker.

[0024]

[0025] Figure 1 is a graph showing the results of a functional evaluation of a hangover remedy according to one embodiment of the present invention.

[0026] Figure 2 is a graph showing detailed results of a self-reported symptom questionnaire evaluation of a hangover remedy according to one embodiment of the present invention.

[0027]

[0028] In the description, if it is determined that a detailed description of a related known technology may obscure the gist of the present invention, the detailed description is omitted.

[0029] Terms such as first, second, etc. may be used to describe various components, but these components should not be limited by these terms. These terms are used solely to distinguish one component from another.

[0030] The terminology used in this application is only used to describe specific embodiments and is not intended to limit the present invention. The singular expression includes the plural expression unless the context clearly indicates otherwise. In this application, it should be understood that the terms "comprise" or "have" indicate the presence of a feature, number, step, operation, component, part, or combination thereof described in the specification, but do not exclude in advance the possibility of the presence or addition of one or more other features, numbers, steps, operations, components, parts, or combinations thereof.

[0031] Hereinafter, an embodiment of a hangover cure according to the present invention will be described in detail with reference to the attached drawings. In describing with reference to the attached drawings, identical or corresponding components are assigned the same drawing numbers, and redundant descriptions thereof will be omitted.

[0032] According to one embodiment of the present invention, a hangover remedy is provided comprising 100 to 200 parts by weight of Indian gooseberry extract, 100 to 150 parts by weight of refined glucose, and 40 to 60 parts by weight of barley sprout powder.

[0033] The hangover remedy of this example comprises Indian gooseberry extract, refined glucose, and barley sprout powder, and when taken by a drinker, can reduce the concentration of acetaldehyde in the blood and alleviate hangover symptoms in the drinker.

[0034] Although the mechanism of hangover caused by alcohol has not been clearly identified, the ethanol component of alcoholic beverages is broken down in the liver by alcohol dehydrogenase (ADH), producing acetaldehyde. The produced acetaldehyde is metabolized into acetate by aldehyde dehydrogenase (ALDH), converted into acetyl-CoA, and used to generate energy or synthesize cholesterol and fatty acids, and some is excreted through urine or sweat. However, it is known that excessive alcohol consumption causes health problems such as liver cell damage and metabolic diseases as well as hangover symptoms due to acetaldehyde and NADH that remain in the body because they are not broken down into acetate during the oxidation process, rather than the alcohol itself. Therefore, the present embodiment can have a hangover relief effect by reducing the concentration of acetaldehyde in the blood that causes hangover symptoms when taken by a drinker.

[0035] Hereinafter, the composition of a hangover remedy according to this embodiment will be described, and the effect of the hangover remedy according to the present invention will be described with reference to FIGS. 1 and 2.

[0036] The hangover remedy of the present embodiment may include 100 to 200 parts by weight of Indian gooseberry extract, 100 to 150 parts by weight of refined glucose, and 40 to 60 parts by weight of barley sprout powder, and may further include 90 to 150 parts by weight of a fruit concentrate including 30 to 50 parts by weight of grape concentrate, 30 to 50 parts by weight of pear concentrate, and 30 to 50 parts by weight of apple concentrate, and may further include an orange extract, a ginger extract, and a walnut fruit extract, which will be described later, and may be manufactured in a tablet form.

[0037] The Indian gooseberry (Phyllanthus emblica, Indian gooseberry, Amla) included in this example is a deciduous tree of the Euphorbiaceae family, known as the fruit of rejuvenation in India, and is a fruit that prevents various diseases and aging and is effective for beauty and health, and is used in the form of food or health supplements not only in India but also in many countries such as China, the UK, and the US. Indian gooseberry contains various antioxidant substances such as vitamin C, phenolic compounds, tannins, phyllem-belic acid, phyllembelin, rutin, curcuminoids, and emblicol, and it has been reported that it has antioxidant activity, cancer treatment and prevention, antidiabetic, hyperlipidemia, and lipid peroxidation inhibition effects.

[0038] The fruit concentrate included in the present embodiment may include grape concentrate, pear concentrate, and apple concentrate, and may each include 30 to 50 parts by weight of grape concentrate, 30 to 50 parts by weight of pear concentrate, and 30 to 50 parts by weight of apple concentrate.

[0039] Here, the grape concentrate can be red grape concentrate, and the apple concentrate can be green apple (unripe apple) concentrate.

[0040] The Indian gooseberry extract and fruit concentrate described above can be used in powder or liquid form.

[0041] The hangover remedy of the present embodiment may further include 30 to 50 parts by weight of orange extract, and the orange extract may be used in powder or liquid form as a Moroblood orange extract.

[0042] In addition, the present embodiment may further include 10 to 30 parts by weight of ginger extract and 10 to 20 parts by weight of walnut fruit extract, and each may be used in powder or liquid form.

[0043] The hangover remedy of the present embodiment may include 2 to 4 parts by weight of vitamin C, 2 to 4 parts by weight of amino acid reversible mix, and magnesium stearate, wherein the amino acid reversible mix may include seven kinds of amino acids, namely L-leucine, L-isoleucine, L-valine, L-arginine, L-glutamine, L-methionine, and L-alanine.

[0044]

[0045] In order to evaluate the hangover relief effect of the above-described example, an experiment was conducted using the test group and control group of the above-described example, and the specific contents of the experiment are as follows.

[0046] First, the experiment to evaluate the effect of this example was conducted by having group A of the test subjects take the test group once, twice (single dose) during the first visit, and group B take the placebo of the control group. After a 7-day rest period from the day of taking the human application food, during the second visit, group A was given the placebo of the control group, and group B was given the test group of this example in a cross-over manner, and the evaluation was conducted.

[0047]

[0048] The test group of the hangover cure of this example was manufactured with one tablet according to the composition shown in Table 1 below, and was provided in the form of a tablet with no off-flavor or off-taste, using Indian gooseberry extract powder as the main ingredient.

[0049]

[0050]

[0051] The control group was prepared with the composition shown in Table 2 below.

[0052]

[0053]

[0054] Subjects who participated in this experiment and completed all schedules according to the protocol without any major violations (PPS; Per Protocol Set) were selected for functional evaluation and analyzed. For the first functional evaluation, blood alcohol concentration, blood acetaldehyde concentration, concentration changes at 0.5, 0.75, 1, 2, 4, 6, and 15 hours before and after drinking, as well as AUC, Tmax, and Cmax, were measured. For the second functional evaluation, an evaluation was conducted using a hangover symptom questionnaire.

[0055] In this experiment, for statistical significance, a p-value less than 5% was considered statistically significant, and statistical analysis was performed using statistical programs such as SAS and SPSS as follows.

[0056] Additionally, this experiment was conducted on a total of 36 subjects, 22 males and 14 females, with an average age of 2625±547 years. In addition, among the test subjects, 10 smoked, smoking approximately 740±357 cigarettes, and 36 drinkers, drinking an average of 472±333 units.

[0057] (Drinking volume: 1 unit of alcohol = 10g = 125mL (calculated as a small glass: 50ml, beer glass: 200ml))

[0058] As shown in Fig. 1, the results of the primary functionality evaluation were as shown in Tables 3 and 4 below, and the analysis results showed that there was no statistically significant difference in blood alcohol concentration between the two intake groups in all items (p>.005), and there was a statistically significant difference in acetaldehyde concentration (0.5 hr and 6 hr) and AUC between the two intake groups (p<.005), and there was no statistically significant difference between the two intake groups in other items (p>.005). From a clinical perspective, there appears to be a difference in the blood acetaldehyde concentration (AUC) values ​​between the test group and the control group, and statistically, it was proven that there was a significant difference as the area of ​​the acetaldehyde concentration value in the test group was smaller than that of the control group (p-value=.0049).

[0059]

[0060]

[0061]

[0062] The hangover symptom questionnaire for the secondary functional evaluation is administered using the Alcohol Hangover Severity Scale (AHSS) questionnaire (see Table 5) after the alcohol challenge test at the first and second visits (15 hours after alcohol consumption), and the severity of each symptom is evaluated on a scale from 0 (absent) to 10 (extreme).

[0063]

[0064]

[0065] As shown in Figure 2, the hangover symptom questionnaire was analyzed by evaluating hangover symptoms 15 hours after alcohol consumption, and the analysis results showed that the test group's scores in the apathy (loss of interest), concentration problems, clumsiness, confusion (mental absentmindedness), sweating (sweat), and trembling (chills) items were significantly lower than those in the control group (p<0.005), and the test group's score was also significantly lower than that in the control group in the total score (p-value=0.0016). This means that the test group had less hangover symptoms than the control group when consuming alcohol, and it can be considered to have secured statistical significance.

[0066]

[0067]

[0068]

[0069] In conclusion, as a result of the functional evaluation through a test to evaluate the hangover effect of this example, there was a statistically significant difference in acetaldehyde concentration (0.5 hr and 6 hr) and AUC (p<0.005), and in the hangover subjective symptoms such as apathy (loss of interest), concentration problems, clumsiness, confusion (mentality), sweating (sweat), and trembling (chills), the scores of the test group were significantly lower than those of the control group, and the total score also showed a significant difference in the scores of the test group compared to the control group (p<0.005).

[0070] Therefore, it was proven that when a healthy adult takes the hangover remedy of this example, it can help with alcohol metabolism by reducing the blood acetaldehyde concentration after alcohol consumption and reducing hangover symptoms.

[0071]

[0072] Above, one embodiment of the present invention has been described, but a person having ordinary skill in the art will be able to modify and change the present invention in various ways by adding, changing, deleting or adding components, etc., within the scope that does not depart from the spirit of the present invention described in the claims, and this will also be considered to be included within the scope of the rights of the present invention.

Claims

1. A hangover remedy comprising 30 to 50 parts by weight of grape concentrate, 30 to 50 parts by weight of pear concentrate, and 30 to 50 parts by weight of apple concentrate.

2. In paragraph 1, A hangover remedy further comprising 90 to 150 parts by weight of fruit concentrate.

3. In paragraph 2, The above fruit concentrate is a hangover remedy including grape concentrate, pear concentrate and apple concentrate.

4. In paragraph 3, The above fruit concentrate is a hangover remedy comprising 30 to 50 parts by weight of grape concentrate, 30 to 50 parts by weight of pear concentrate, and 30 to 50 parts by weight of apple concentrate.

5. In paragraph 1, A hangover remedy further comprising 30 to 50 parts by weight of orange extract.

6. In paragraph 1, A hangover remedy further comprising 10 to 30 parts by weight of ginger extract.

7. In paragraph 1, A hangover remedy further comprising 10 to 20 parts by weight of extract of the fruit of the Chinese juniper tree.

8. In paragraph 1, A hangover remedy further comprising 2 to 4 parts by weight of vitamin C.

9. In paragraph 1, A hangover remedy further comprising 2 to 4 parts by weight of amino acid reversible.

10. In paragraph 1, A hangover remedy that further contains magnesium stearate.

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