Cosmetic composition

Abstract

Disclosed herein are cosmetic compositions. More particularly, disclosed herein are cosmetic compositions comprising at least one compound of General Formula (1), including but not limited to N,N,N',N'-tetrakis(2-hydroxyethyl)ethylenediamine (THEED), tetrahydroxypropyl ethylenediamine (THPE), and N,N,N',N'-tetrakis(2-hydroxypentyl)ethylenediamine, and at least one skin care benefit agent for combating the harmful effects of atmospheric pollution relating to hyperpigmentation in human skin.

Description

[0001] COSMETIC COMPOSITION

[0002] Field of the Invention

[0003] Disclosed herein are cosmetic compositions. More particularly, disclosed herein are cosmetic compositions comprising at least one compound of General Formula (1), including but not limited to N,N,N',N'-Tetrakis(2-hydroxyethyl)ethylenediamine (THEED), tetrahydroxypropyl ethylenediamine (THPE), and N,N,N',N'-Tetrakis(2-hydroxypentyl)ethylenediamine, and at least one skin care benefit agent selected from acetyl glutamic acid, acetyl glutamine, acetyl methionine, acetyl tyrosine, and combinations thereof for combating the harmful effects of atmospheric pollution relating to hyperpigmentation in human skin.

[0004] Background of the Invention

[0005] Chemical substances such as aromatic hydrocarbons such as dioxin and aromatic hydrocarbons (PAHs) are present in the air and atmosphere. Exposure such as by inhaling such chemical substances in the air can harm the human body in various aspects. For example, pollutants in the atmosphere may cause inflammation in the cells of the body, resulting in irritation, overproduction of certain substances like melanin (i.e., the natural skin pigment present in human skin) produced by cells, and even cancer.

[0006] The present inventors have surprisingly found cosmetic compositions comprising at least one compound of General Formula (1), including but not limited to N,N,N',N'-tetrakis(2- hydroxyethyl)ethylenediamine (THEED), tetrahydroxypropyl ethylenediamine (THPE), and N,N,N',N'-tetrakis(2-hydroxypentyl)ethylenediamine, and at least one skin care benefit agent are effective for combating the harmful effects of atmospheric pollution, particularly that relating to hyperpigmentation in human skin. “Hyperpigmentation,” as used herein, refers to an area of skin wherein greater pigmentation than that of an adjacent area of skin is present, such as in the case of a sun / age spot or post-inflammatory hyperpigmentation (PIH). Thus, cosmetic compositions comprising at least one compound of General Formula (1) and at least one skin care benefit agent as described herein, fill this pollution-combatting need in consumers struggling with pollution-induced hyperpigmentation. Additional Information

[0007] Efforts have been disclosed for using tetrahydroxypropyl ethylenediamine or skin care benefit agents in compositions.

[0008] U.S. Patent No. RE41.339 describes compositions comprising N-acetyl-aldosamines, N- acetylamino acids, and related N-acetyl compounds useful to alleviate or improve various cosmetic conditions and dermatological disorders.

[0009] U.S. Patent Application Publication No. 2009 / 0227683 relates to compositions providing analgesic effects to skin. The examples describe a composition containing tetrahydroxypropyl ethylenediamine, glycerin, D-panthenol, Nipagin M, and Nipasol M.

[0010] U.S. Patent Application Publication No. 2016 / 0324754 provides for a shaving cream composition comprising water, carbomer, ethylhexylpalmitate, glycerin, glyceryl acrylate / acrylic acid, isododecane, stearic acid, butylene glycol, ethyl alcohol, cetearyl alcohol, ceteareth-20, propanediol, Brassica Campestris, phenoxyethanol, ethylhexylglycerin, tetrahydroxypropyl ethylenediamine, Aloe Barbadensis, carboxymethylhydroxyethylcellulose, bisabolol, PEG-45M, and tocopheryl acetate.

[0011] None of the additional information above describes the claimed cosmetic composition as disclosed herein.

[0012] Summary of the Invention

[0013] Accordingly, in a first aspect, the inventive composition relates to a cosmetic composition comprising at least one skin care benefit agent, and at least one compound of General Formula

[0014] where Ri, R2, R3, R4 are each, independently, a linear or branched carbon chain having 2 to 6 carbon atoms; and Rs is a carbon chain having 1 to 6 carbon atoms; in a cosmetically acceptable vehicle.

[0015] In a second aspect, there is provided a cosmetic composition comprising at least one skin care benefit agent and at least one skin care active comprising caffeine, ubiquinone, hydrolyzed rice protein, bisabolol, carnosine, Nannochloropsis Oculata extract, Gleditsia Triacanthos Seed extract, Zingiber Officinale (Ginger) Root extract, menthoxypropanediol, or a combination thereof.

[0016] In a third aspect, there is provided a method of providing a skin benefit to skin comprising: applying a cosmetic composition to the skin, wherein the cosmetic composition comprises at least one skin care benefit agent and at least one compound of General Formula (1), where R1, R2, R3, R4are each, independently, a linear or branched carbon chain having 2 to 6 carbon atoms; and R5is a carbon chain having 1 to 6 carbon atoms; in a cosmetically acceptable base, wherein a weight ratio of the skin care benefit agent to the compound of General Formula (1) is present from 75:1 to 1 :75, preferably, from 65:1 to 1 :50, and, more preferably, from 55:1 to 1 :25.

[0017] In a fourth aspect, there is provided a method of reducing pollution-induced hyperpigmentation in skin comprising a step consistent in applying to the skin a cosmetic composition comprising at least one skin care benefit agent and at least one compound of General Formula (1), preferably, tetrahydroxypropyl ethylenediamine.

[0018] In a fifth aspect, there is provided a use of the cosmetic composition for at least one skin care benefit, preferably, skin tone and / or skin texture, more preferably, for reducing pigmentation of skin.

[0019] All other aspects of the present cosmetic compositions will become more readily apparent upon considering the detailed description and examples which follow. Unless explicitly stated otherwise, all ranges described herein are meant to include all ranges subsumed therein. The term “comprises” is meant to encompass the terms consisting essentially of and consisting of.

[0020] The term “skin” as used herein includes the skin on the face, neck, chest, back, arms, axilla, buttocks, hands, legs and scalp. Skin benefit agent, as used herein, is meant to include a component that improves a facial or body characteristic after topical application like a skin characteristic and / or benefits the same wherein the skin benefit agent can be, and preferably is, a skin benefit agent in a cream, pump or aerosol spray, serum, lotion, balm, deodorant, gel, or wash composition. In an especially preferred embodiment, the composition is a leave-on composition.

[0021] Except in the examples, or where otherwise explicitly indicated, all numbers in this description indicating amounts of material are to be understood as modified by the word "about." All amounts are by total weight of the composition, unless otherwise specified.

[0022] The disclosure of the invention as found herein is to be considered to cover all aspects as found in the claims as being multiply dependent upon each other irrespective of the fact that claims may be found without multiple dependency or redundancy. Unless otherwise specified, numerical ranges expressed in the format "from x to y" are understood to include x and y. In specifying any range of values or amounts, any particular upper value or amount can be associated with any particular lower value or amount. All percentages and ratios contained herein are calculated by weight unless otherwise indicated.

[0023] Detailed Description of the Invention

[0024] Cosmetic compositions disclosed herein comprise at least one skin care benefit agent. The skin care benefit agent, as described herein, is selected from acetyl glutamic acid (e.g., N-acetyl glutamic acid), acetyl glutamine (e.g., N-acetyl glutamine), acetyl methionine (e.g., N-acetyl methionine), acetyl tyrosine (e.g., N-acetyl tyrosine), and combinations thereof, including as a free acid, amide, ester, lactone, isomer, and any derivatives or salts thereof. The term “derivative(s)” as used with reference to ingredients herein refers to an amide, ester, ether, carboxyl, amino, acetyl, and / or alcohol forms of the particular ingredient. “Salts,” as used herein, includes but is not limited to ammonium, calcium, magnesium, manganese, potassium, sodium, tetraalkylammonium, trialkylammonium, and a combination thereof. In a further aspect, the skin care benefit agent may be present in any of its isomeric forms and in combinations thereof. “Isomers,” as used herein, is meant to include D-isomers, L-isomers, and / or DL- isomers for a particular compound. Thus, the skin care benefit agent comprises its D-isomer form, L-isomer form, DL-isomer form, or a combination thereof. For example, N-acetyl methionine may be present in any of its isomeric forms and in combinations thereof. For example, N-acetyl-DL-methionine (i.e., is in its DL-isomer form), N-acetyl-D-methionine (i.e., is in its D-isomer form) and N-acetyl-L-methionine (i.e., is in its L-isomer form).

[0025] Typically, the skin care benefit agent is present in the cosmetic composition disclosed herein in an amount of from 0.0001 to 10%, or from 0.0005 to 8%, or from 0.001 to 6%, or from 0.005 to 5%, or from 0.01 to 4%, or from 0.02 to 3.5%, or from 0.025 to 3%, or from 0.05 to 2.5%, or from 0.1 to 2.5%, or from 0.1 to 2%, or from 0.2 to 1.5% by weight of the cosmetic composition. In another aspect, the skin care benefit agent is present in the cosmetic composition in an amount from 0.001 to 5%, or from 0.005 to 4%, or from 0.01 to 3%, or from 0.05 to 3%, or from 0.1 to 3%, or from 0.25 to 2% by weight of the cosmetic composition.

[0026] Where the cosmetic composition comprises acetyl methionine, acetyl methionine (or N-acetyl methionine) has the following Structural Formula (which is available from numerous suppliers, including Sigma-Aldrich):

[0027] In one aspect, at least 50%, or at least 70%, or at least 80%, or at least 90%, or 100% by weight of the skin care benefit agent comprises acetyl methionine. In one aspect, from 50 to 100%, or from 60 to 100%, or from 70 to 100%, or from 80 to 100%, or from 90 to 100%, or from 80 to 95%, or from 85 to 95%, by weight, of the skin care benefit agent comprises acetyl methionine.

[0028] Cosmetic compositions disclosed herein also comprise at least one compound of General Formula (1):

[0029] where Ri, R2, R3, R4 are each, independently, a linear or branched carbon chain having 2 to 6 carbon atoms; and Rs is a carbon chain having 1 to 6 carbon atoms.

[0030] In one aspect, the compound of general formula (1) comprises: a) N,N,N',N'-tetrakis(2-hydroxyethyl)ethylenediamine, where RI=R2=R3=R4=C2; and Rs=C2 (i.e., THEED); b) N,N,N',N'-tetrakis(2-hydroxypropyl)ethylenediamine, where RI=R2=R3=R4=C3; and Rs=C2 (i.e., tetrahydroxypropyl ethylenediamine (THPE)); and c) N,N,N',N'-tetrakis(2-hydroxypentyl)ethylenediamine, where RI=R2=R3=R4=C5; and R5=C2.

[0031] Preferably, a compound of general formula (1) is selected from THEED, THPE, N,N,N',N'- tetrakis(2-hydroxypentyl)ethylenediamine, or a combination hereof. More preferably, a compound of general formula (1) is THPE. THPE has the following structural formula:

[0032] THPE generally is used as an emulsion stabilizer, a dispersing agent, a solvent, a pH adjuster, and / or a chelating agent in cosmetic formulations. THPE is commercially available, for example, as Quadrol® or Neutrol® TE from BASF. The cosmetic composition comprises from 0.0001 to 10%, or from 0.0001 to 7.5%, or from 0.0001 to 5%, or from 0.0002 to 5%, or from 0.0002 to 4%, or from 0.0002 to 3%, or from 0.0002 to 2.5% by weight of a compound having General Formula (1). In one aspect, the cosmetic composition comprises from 0.001 to 6%, or from 0.001 to 5%, or from 0.005 to 4%, or from 0.01 to 5%, or from 0.05 to 4%, or from 0.1 to 4%, or from 0.5 to 3%, or from 0.1 to 2.5% by weight of a compound having General Formula (1).

[0033] Additional examples a compound of General Formula (1) include 1 ,T,T',1"'-(1,3- propanediyldinitrilo)tetrakis-2-propanol; 1 , T, 1", 1 "'-(1 ,5-pentanediyldinitrilo)tetrakis-2-propanol;

[0034] 1 , T, 1", 1 "'-(1 ,6-hexanediyldinitrilo)tetrakis-2-propanol.

[0035] The skin care benefit agent to the compound of General Formula (1) is present in a weight ratio of from 75:1 to 1 :75, or from 65:1 to 1 :50, or from 55:1 to 1:25, or from 50:1 to 1 :10, or from 50:1 to 1:5. In one aspect, the skin care benefit agent to the compound of General Formula (1) is present in a weight ratio of from 60:1 to 1:0.5, or from 60:1 to 1:1 , or from 55:1 to 5:1, or from 55:1 to 7:1, or from 50:1 to 10:1. In another aspect, the acetyl methionine to THPE is present in a weight ratio of from 60:1 to 1 :0.5, or from 60:1 to 1 :1, or from 55:1 to 5:1 , or from 55:1 to 7:1 , or from 50:1 to 10:1.

[0036] In a preferred aspect, the present invention provides a composition for reducing pollution- induced hyperpigmentation containing at least one skin care benefit agent and at least one compound of General Formula (1), where Ri, R2, R3, R4 are each, independently, a linear or branched carbon chain having 2 to 6 carbon atoms; and R5is a carbon chain having 1 to 6 carbon atoms; in a cosmetically acceptable base, wherein a weight ratio of the skin care benefit agent to the compound of General Formula (1) is present from 75:1 to 1 :75, preferably, from 65:1 to 1:50, and, more preferably, from 55:1 to 1:25.

[0037] Examples of atmospheric pollutants include substances included in Standard Reference Material (SRM) 1648a as supplied by the National Institute of Standards and Technology (NIST). More particularly, examples of such atmospheric pollutants include polycyclic aromatic hydrocarbons (PAHs), nitro-polycyclic aromatic hydrocarbons, polychlorinated biphenyls, and the like, preferably PAHs.

[0038] PAHs are chemicals that are formed during the incomplete burning of organic substances, such as fossil fuels, and is a pollutant commonly found in the air. For purposes of the cosmetic compositions disclosed herein, the pollutants are in particular polycyclic aromatic hydrocarbons (PAHs), preferably, acenaphthene, acenaphthylene, anthracene, benzanthracene, benzochrysene, benzofluoranthene, benzoperylene, benzopyrene, bromomethylnaphthalene, chrysene, corannulene, coronene, dibenzanthracene, dibenzofluroanthene, fluoranthrene, fluorene, indenopyrene, methylphenanthrene, 1 -naphthalene, naphthalene, ovalene, pentacene, phenanthrene, phenylene, phthalic acid, picene, pyrene, tetracene, triphenylene, or a combination thereof. In one aspect, the PAH is chrysene. Chrysene is commonly found in coal tar.

[0039] The “cosmetic composition”, “cosmetically acceptable composition” or “dermatologically acceptable composition”, means that the compositions or components thereof so-described are suitable for use in contact with skin, particularly human skin, without undue toxicity, incompatibility, instability, irritation, or allergic response. Such compositions may be a liquid, cream, pump or aerosol spray, serum, lotion, balm, deodorant, foam, scrub, wash, concentrates and / or powder which can be easily hydrated or applied with an implement or via a face mask or a pad composition. Cosmetic compositions for use in the invention may also be formulated in solid forms such as gels or sticks. In one aspect, combinations of any of the above-described product forms may also be used. The composition is a leave-on composition. The term "leave- on", as described herein, refers to a composition that is applied to or rubbed on the skin and left thereon.

[0040] In addition to the skin care benefit agent as described herein and the compound of General Formula (1) as described herein, the cosmetic composition as described herein, includes a cosmetically acceptable carrier. As used herein, the term "cosmetically acceptable carrier", "cosmetically acceptable excipient", "dermatologically acceptable carrier" or "dermatologically acceptable excipient" can include all solvents, dispersion media, coatings, antibacterial agents, antifungal agents, isotonic and absorption delaying agents, mixtures thereof or the like, as long as the same are cosmetically acceptable or dermatologically acceptable. Except insofar as any conventional media or agent is incompatible with the active ingredient, its use in the cosmetic compositions is contemplated. Supplementary active ingredients can also be incorporated into the compositions. Cosmetically acceptable carriers are suitable for topical application to the skin, have good aesthetic properties, are compatible with the active agents described herein and any other components, and cause minimal or no safety or toxicity concerns. In one aspect, the cosmetically acceptable carrier may comprise an aqueous phase, an oil phase, an alcohol, a silicone phase, or a mixture thereof, and may be in the form of an emulsion. Emulsions can have a range of consistencies including gels, thin lotions (which may also be suitable for spray or aerosol delivery), creamy lotions, light creams, and heavy creams. Exemplary emulsions include water-in-oil emulsions, oil-in-water emulsions, silicone-in-water emulsions, water-in-silicone emulsions, polyol-in-silicone emulsions, silicone-in-polyol emulsions, polyol-in-oil emulsions, oil-in-polyol emulsions, wax-in-water emulsions and water- oil-water triple emulsions. Preferred emulsions include oil-in-water (“O / W”) emulsions and water-in-oil (“W / O”) emulsions.

[0041] Cosmetic compositions in the form of an emulsion, and suitable for use in the invention, typically have an oil phase containing at one or more cosmetically acceptable fatty materials which may be liquid or solid at room temperature (25°C).

[0042] Suitable cosmetically acceptable fatty materials include naturally derived oils (such as sunflower oil, borage oil, soybean oil, castor oil, olive oil and almond oil); esters of monoalcohols or of polyols with monocarboxylic or polycarboxylic acids, at least one of the alcohols and / or acids comprising at least one hydrocarbon-based chain containing at least 6 carbon atoms (such as octyl palmitate, isopropyl myristate, isopropyl palmitate, isopropyl isostearate, hexyl laurate, isohexyl laurate, isohexyl palmitate, decyl oleate, isodecyl oleate, hexadecyl stearate, decyl stearate, dihexyldecyl adipate, lauryl lactate, myristyl lactate, myristoyl myristate, cetyl lactate, oleyl stearate, oleyl oleate, oleyl myristate, lauryl acetate, cetyl propionate, isononyl isononanoate, propylene glycol dicaprate, diisopropyl adipate, dibutyl adipate, dicaprylyl carbonate, and oleyl adipate); ethers (such as dicapryl ether); fatty alcohols (such as cetyl alcohol, stearyl alcohol and behenyl alcohol); isoparaffins (such as isooctane, isododecane and isohexadecane); silicone oils (such as dimethicones, cyclic silicones, and polysiloxanes); and hydrocarbon oils (such as mineral oil, petrolatum and polyisobutene); fatty acids containing from 8 to 30 carbon atoms (such as stearic acid, lauric acid, palmitic acid and oleic acid); vegetable fats (such as cocoa butter, coconut oil, palm oil and shea butter); natural or synthetic waxes (such as lanolin wax, beeswax, carnauba wax, candelilla wax, paraffin wax, lignite wax, microcrystalline waxes, ceresin, ozokerite, and polyethylene waxes), hydrogenated oils which are solid at 25°C (such as hydrogenated castor oil, hydrogenated jojoba oil, hydrogenated palm oil, hydrogenated tallow and hydrogenated coconut oil) and fatty esters that are solid at 25°C (such as C20-40 alkyl stearate). In one aspect, mixtures and / or combinations of any of the above-described materials may also be used. In one aspect, suitable fatty materials may be included in the cosmetic composition, as described herein, in an amount may range from 1 to 40%, or from 3 to 30%, or from 4 to 20%, or from 5 to 18%, or from 6 to 17%, or from 7 to 15%, or from 1 to 18%, or from 2 to 15%, or from 3 to 15%, or from 5 to 12% by weight of the composition. It is also within the scope of the cosmetic compositions to include sunscreens and photostabilizers as desirable cosmetically acceptable fatty materials. The sunscreens and photostabilizers that may be used in the cosmetic compositions include such materials as octylmethoxycinnamate (also known as ethylhexyl methoxycinnamate or OMK; commercially available as PARSOL® MCX), and ethylhexyl salicylate (also known as octisalate). Other sunscreens desirable for use include p-aminobenzoic acid (PABA), octyl dimethyl-PABA (also known as ethylhexyl dimethyl PABA), homomenthyl salicylate (also known as homosalate), menthyl anthranilate, benzophenone-4, triethanolamine salicylate, iscotrizinol (also known as diethylhexyl butamido triazone), octyl triazone (also known as ethylhexyl triazone), polysilicone-15, isopentenyl-4- methoxycinnamate (also known as isoamyl 4-methoxycinnamate), mixtures thereof or the like. Also desirable for use is octocrylene. In a preferred embodiment, the oil in the cosmetically acceptable vehicle comprises ethylhexyl triazone, homosalate, octisalate, octylmethoxycinnamate, or a mixture thereof.

[0043] In a preferred embodiment, illustrative examples of fatty materials that may be used in the compositions disclosed herein include, caprylic / capric triglycerides, a cyclic silicone (e.g., cyclopentasiloxane, cyclohexasiloxane), dimethicone, ethylhexyl triazone, homosalate, isodecyl neopentanoate, isopropyl myristate, isopropyl palmitate, octisalate, octocrylene, octylmethoxycinnamate, silicones, triolein, and a mixture thereof. In another preferred embodiment, caprylic / capric triglycerides, ethylhexyl triazone, homosalate, isodecyl neopentanoate, isopropyl myristate, isopropyl palmitate, octisalate, octocrylene, octylmethoxycinnamate, triolein, and a mixture thereof. Preferably, the oil comprises caprylic / capric triglycerides, dimethicone, isodecyl neopentanoate, isopropyl myristate, isopropyl palmitate, triolein, or a mixture thereof. More preferably, the oil comprises caprylic / capric triglycerides, dimethicone, isopropyl myristate, or a mixture thereof. Most preferably, the oil comprises caprylic / capric triglycerides, isopropyl myristate, or a mixture thereof.

[0044] Cosmetic compositions in the form of an emulsion, and suitable for use in the invention, typically have an aqueous phase, which may also include one or more organic liquids that are miscible with water at room temperature (25°C). Exemplary water-miscible organic liquids include monohydric and polyhydric alcohols and derivatives thereof such as C2-C6 alkanols (such as ethanol and isopropanol); C2-C10 glycols and polyols (such as glycerol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, caprylyl glycol, dipropylene glycol, and diethylene glycol); C3-C16 glycol ethers (such as mono-, di-, or tripropylene glycol (C1-C4) alkyl ethers and mono-, di-, or triethylene glycol (C1-C4) alkyl ethers) and polyethylene glycol having 2 to 12 oxyethylene units. In one aspect, a mixture and / or combination of any of the above-described materials may also be used.

[0045] In one embodiment, the cosmetically acceptable vehicle comprises more than or equal to 40% aqueous phase, or more than or equal to 50% aqueous phase, or more than or equal to 60% aqueous phase, or more than or equal to 75% aqueous phase, or more than or equal to 80% aqueous phase by weight of the vehicle. In another embodiment, the cosmetically acceptable vehicle comprises from 40 to 98%, or from 50 to 97%, or from 60 to 95%, or from 75 to 92% aqueous phase by weight of the composition.

[0046] Cosmetic compositions in the form of an emulsion, and suitable for use in the invention, generally include surface active ingredients, such as emulsifiers and solubilizers, to enable two or more immiscible components to be combined homogeneously and to help stabilize the composition. In an embodiment, the emulsifier may be selected from the group consisting of anionic, nonionic, cationic, and amphoteric surfactants. In one embodiment, the emulsifier is an isethionate (e.g., Cs-Cis acyl isethionate), taurate (e.g., acyl taurate), glutamate (e.g., acyl glutamate), glycinate, sarcosinate, sulfosuccinate (e.g., monoalkyl sulfosuccinate), or a mixture thereof. In another embodiment, emulsifiers that may be used to form O / W or W / O emulsions include sorbitan oleate, sorbitan sesquioleate, sorbitan isostearate, sorbitan trioleate, PEG-20 sorbitan isostearate, polyglyceryl-3-diisostearate, polyglycerol esters of oleic / isostearic acid, polyglyceryl-6 hexaricinolate, polyglyceryl-4-oleate, polyglyceryl-4 oleate / PEG-8 propylene glycol cocoate, polyglyceryl-2 dipolyhydroxystearate, PEG-30 dipolyhydroxystearate, oleamide DEA, TEA myristate, TEA stearate, magnesium stearate, sodium stearate, potassium laurate, potassium ricinoleate, sodium cocoate, sodium tallowate, sodium cocoyl isethionate, sodium lauroyl isethionate, potassium castorate, sodium oleate, cetyl phosphate, diethanolamine cetyl phosphate, potassium cetyl phosphate, sodium glyceryl oleate phosphate, alkyl sulfates and sulfonates, alkylbenzene sulfonates, alkyl and dialkyl sulfosuccinates, C8-C20 acyl isethionates, C8-C20 acyl methyl isethionates, C8-C20 acyl methyl taurates, sodium cocoyl glutamate, sodium cocoyl glycinate, dimethicone copolyol, cetyl dimethicone copolyol, octyldimethicone ethoxyglucoside copolyol, dimethicone copolyol crosspolymer, laurylmethicone copolyol, cocoamidopropyl betaine, C12-C20 trialkyl betaines, sodium lauroamphoacetate, and sodium laurodiamphoacetate. In one aspect, mixtures and / or combinations of any of the abovedescribed materials may also be used. In one aspect, surface active ingredient(s) may be included in the cosmetic composition, as described herein, in an amount may range of from 0.1% to 20%, or 1% to 10%, or 1 % to 8%, by weight of the composition, including all ranges subsumed therein. Cosmetic compositions for use in the invention may also be formulated in a single-phase carrier such as water and / or one or more water miscible organic liquids (such as the monohydric and polyhydric alcohols and derivatives thereof described above).

[0047] Skin Care Actives

[0048] Cosmetic compositions for use in the invention may comprise a resorcinol. A resorcinol is a monohydroxy phenol compound (i.e. , 1,3-dihydroxybenzene or 1,3-benzenediol) characterized by alcohol groups (—OH) at positions 1 and 3. The chemical structure of resorcinols may be modified, resulting in substituted resorcinols characterized by at least one substituent in the 2, 4, 5 or 6 position. Substituted, as used herein, refers to a compound in which one or more hydrogen atoms are replaced by another atom or group, e.g., substituent. In one aspect, the substituted resorcinol comprises at least one substituent comprising 5 to 11 carbon atoms, or 5 to 9 carbon atoms. In one aspect, the substituted resorcinol has at least one substituent comprised of an alkyl group or unsaturated alkyl group.

[0049] In one aspect, the substituted resorcinol is only substituted at position 4 with an alkyl group, e.g., the substituted resorcinol is a 4-substituted alkyl resorcinol, including but not limited to 4- methyl resorcinol, 4-ethyl resorcinol, 4-hexyl resorcinol, 4-cyclohexyl resorcinol, 4-propyl resorcinol, 4-isopropyl resorcinol, 4-butyl resorcinol, 4-pentyl resorcinol, 4-phenylethyl resorcinol, 4-cyclopentyl resorcinol, 4-cyclohexyl resorcinol, 4-heptyl resorcinol, 4-cycloheptyl resorcinol, 4-octyl resorcinol, 4-cyclooctyl resorcinol, 4-nonyl resorcinol, 4-decyl resorcinol, 4- undecyl resorcinol, 4-dodecyl resorcinol and / or combinations or mixtures thereof. Preferably, the substituted resorcinol is 4-ethylresorcinol, 4-hexylresorcinol, and 4-isopropylresorcinol. In one aspect, the substituted resorcinol is substituted at position 4 with a substituted or unsubstituted 5- or 6-membered ring carbon-based heterocyclic ring containing one or more heteroatoms selected from N, S or O, preferably a substituted 5-membered ring carbon-based heterocyclic ring containing two heteroatoms selected from N or S, e.g., isobutylamido thiazolyl resorcinol or thiamidol. When used, from 0.0001 wt% to 10 wt%, or from 0.0001 wt% to 5 wt%, or from 0.001 wt% to 8 wt%, or from 0.01 wt% to 5 wt%, or from 0.01 wt% to 3 wt%, or from 0.01 to 2.5 wt%, or from 0.01 wt% to 2 wt%, or from 0.01 wt% to 1 wt%, by weight of each of such ingredients, based on the total weight of the emulsion. A cosmetic composition in accordance with the invention disclosed herein may also include additional skin care actives which may be used to obtain a skin care benefit (e.g., for improving the physical and / or aesthetic characteristics of the skin). Examples of additional skin care actives which are suitable for use in the invention include vitamins, minerals and / or antioxidants, emollients, humectants, skin lightening agents, sunscreens, photostabilizers, antiirritants, exfoliating agents, and / or any combinations or mixtures thereof. In one aspect, the cosmetic composition substantially free of sulfates, preferably, having less than 5%, or less than 3%, or less than 1 %, or less than 0.5%, or less than 0.1% of sulfates, by weight of the composition.

[0050] It is within the scope of the cosmetic compositions to optionally include one or more antioxidants, which may be natural, naturally derived, or synthetic antioxidants. Antioxidants may be any antioxidant desirable for use in cosmetic compositions. Illustrative but nonlimiting examples of such antioxidants comprise alpha hydroxy acids (e.g., citric acid, lactic acid, glycolic acid, and mandelic acid), beta-hydroxy acids (e.g., propanoic acid and salicylic acid), butylated hydroxytoluene (BHT), carotenes, carotenoids, co-enzyme Q10 (ubiquinone), carnosine, didodecyl 3,3' thiodipropionate, glutathione, imidazole and derivatives thereof, octadecyl di-t- butyl-4-hydroxyhydrocinnamate, pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate, peptides and derivatives thereof, plant extracts (e.g., Rosmarinus officinalis (rosemary) leaf extract and Camellia sinesis (green tea) leaf extract), polyhydroxy acids (e.g., gluconic acid, gluconolactone and lactobionic acid), polyphenols (e.g., anthocyanin, ellagic acid, flavonoid, tannin), and resveratrol.

[0051] Another class that may be used in the inventive cosmetic composition as antioxidants includes vitamins. As used herein, “vitamins” refers to vitamins, pro-vitamins, and salts, isomers, and derivatives thereof. Illustrative vitamins include, but are not limited to, vitamin A, vitamin Bi, vitamin B2, vitamin B3 (niacinamide), vitamin B5 (panthenol), vitamin Be, vitamin C, vitamin E, vitamin F, vitamin K, folic acid, and biotin. Derivatives of the vitamins may also be employed. For instance, vitamin A and its precursors or derivatives include retinoids such as retinaldehyde, retinoic acid, retinol, retinyl acetate, retinyl palmitate, retinyl propionate, and carotenoids like betacarotene. The composition may also include vitamins such as vitamin B3 and its precursors or derivatives (such as niacinamide or picolinamide); vitamin B5 and its precursors or derivatives (such as panthenol and its precursors or derivatives); vitamin C and its precursors or derivatives (such as tetrahexyldecyl ascorbate, ascorbyl palmitate); vitamin D and its precursors or derivatives, vitamin E and its precursors or derivatives (such as d-alpha-tocopherol, tocopheryl acetate); vitamin K and its precursors or derivatives. In one embodiment, if included, the cosmetic composition further comprises vitamin A and its precursors or derivatives, vitamin B3 and its precursors or derivatives, or a mixture thereof. In another embodiment, if included, the cosmetic composition further comprises retinol, retinyl palmitate, retinyl propionate, niacinamide, picolinamide, or a mixture thereof. In yet another embodiment, the cosmetic composition further comprises at least one of a vitamin B3compound, a resorcinol compound, or a combination thereof.

[0052] It is preferred that, if included, the antioxidant comprises butylated hydroxytoluene (BHT), didodecyl 3,3' thiodipropionate, octadecyl di-t-butyl-4-hydroxyhydrocinnamate, pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate, polyphenols, or a mixture thereof. The total weight percent of antioxidants that may be present in the cosmetic compositions disclosed herein is preferably from 0.01 to 4%, or from 0.02 to 3%, or from 0.05 to 2.5%, or from 0.15 to 2%, or from 0.2 to 2% by weight of the cosmetic composition.

[0053] Emollients suitable for use in the invention include diesters having at least one Cs-22 fatty chain (such as dibutyl adipate, diethyl sebacate, diisopropyl dimerate, and dioctyl succinate); branched chain esters having at least one Cs-22 fatty chain (such as 2-ethylhexyl myristate, isopropyl stearate and isostearyl palmitate); tribasic acid esters having at least one Cs-22 fatty chain (such as triisopropyl trilinoleate and trilauryl citrate), straight chain esters having at least one Cs-22 fatty chain (such as lauryl palmitate, myristyl lactate, and stearyl oleate); C10-20 fatty alcohols and acids (such as cetyl, myristyl, palmitic and stearyl alcohols and acids); and C10-40 hydrocarbons (such as mineral oil, petroleum jelly, squalene, and isoparaffins). In one aspect, mixtures and / or combinations of any of the above-described materials may also be used. In one aspect, emollient(s) may be included in the cosmetic composition, as described herein, in an amount of from 0.05% to 6%, or from 0.07% to 5%, or from 0.1 % to 3%, by weight of the composition.

[0054] Humectants suitable for use in the invention include amino acids, chondroitin sulfate, glycerin, diglycerin, triglycerin, polyglycerin, polypropylene glycol, polyethylene glycol, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, 1 ,3-propanediol, isopentyldiol, hexylene glycol, 1 ,3-butylene glycol, 1 ,4-butylene glycol, ethylene glycol monoalkyl ether, diethylene glycol monoalkyl ether, erythritol, fructose, glucose, maltose, sucrose, lactose, xylose, inositol, lactitol, xylitol, sorbitol, mannitol, maltitol, panthenol, pentaerythritol, 1 ,2,6-hexanetriol, honey, hyaluronic acid, hydrogenated honey, hydrogenated starch hydrolysate, natural moisturization factor, PEG-15 butanediol, saccharide isomerate, polyglyceryl sorbitol, sodium and potassium salts of pyrollidone carboxylic acid, sodium glucuronate, trehalose, and urea. In one aspect, mixtures and / or combinations of any of the above-described materials may also be used. In one aspect, humectant(s) may be included in the cosmetic composition, as described herein, in an amount of from 0.1 % to 15%, or from 0.5% to 12%, or from 1 % to 10%, by weight of the topical composition.

[0055] Additional skin care actives suitable for use in the invention include natural botanical skin lightening agents derived from plant materials (such as Arctostaphylos patula and Arctostaphylos viscida extracts, Emblica officinalis extract, Mitracarpus scaber extract, Uva ursi (bearberry) extract, Moringa oleifera (Moringa) seed oil, Morus bombycis (mulberry) extract, Morus alba (white mulberry) extract, Broussonetia papyrifera (paper mulberry) extract, licorice extract, acerola cherry extract, Chlorella vulgaris extract, Aloe ferrox extract, hydrolyzed rice protein; Nannochloropsis Oculata extract, Gleditsia Triacanthos Seed extract; Zingiber Officinale (Ginger) Root extract, and Rumex occidentalis extract); synthetic or natural sugar amines (such as glucosamine, N-acetyl glucosamine, glucosamine sulfate, mannosamine, N- acetyl mannosamine, galactosamine, N-acetyl galactosamine and their hydrochloride salts); caffeine; kojic acid and C2-20 esters thereof (such as kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid monostearate and kojic acid monobenzoate); hydroquinone, hydroquinone monomethyl ether, hydroquinone monoethyl ether, hydroquinone monobenzyl ether, a- and p-arbutin, deoxyarbutin (4-[(tetrahydro-2H-pyran-2-yl)oxy]phenol), mequinol (4-hydroxyanisole), cysteine, azelaic acid, magnesium ascorbyl phosphate, peroxides (such as hydrogen peroxide, zinc peroxide, sodium peroxide and benzoyl peroxide); 2- mercaptonicotinoyl glycine (2-MNG); 3-aminotyrosine, glycyrrhizinic acid, petroselinic acid, conjugated linoleic acid, stearic acid, palmitic acid, and 12- and / or 10-hydroxystearic acid. In one aspect, mixtures and / or combinations of any of the above-described materials may also be used. In another aspect, the cosmetic composition further comprises palmitic acid, stearic acid, 12-hydroxystearic acid, glycerol, or a mixture thereof. In still another aspect, skin benefit agent(s) may be included in the cosmetic composition, as described herein, in an amount of from 0.001 % to 12%, or from 0.001% to 10%, or from 0.01 % to 8%, by weight of the composition, including all ranges subsumed therein.

[0056] Sunscreens suitable for use in the invention protect the skin from ultraviolet (UV) solar radiation falling within both the UVB region (between 290 nm to 320 nm wavelengths) and the UVA region (between 320 nm and 400 nm wavelengths). Additional examples of optional sunscreens to include in the cosmetic compositions herein include phenylbenzimidazole sulfonic acid (Ensulizole), Avobenzene (butyl methoxydibenzoylmethane; commercially available as PARSOL® 1789), benzophenone-1 , benzophenone-2, benzophenone-3 (also known as oxybenzone), benzophenone-6, benzophenone-8, benzophenone-9, benzophenone- 12, 4-methyl benzylidene camphor, terephthalylidene dicamphor sulfonic acid, bisoctrizole (also known as methylene bis-benzotriazolyl tetramethylbutylphenol), bisethylhexyloxyphenol methoxyphenyl triazine, bisdisulizole disodium (also known as disodium phenyl dibenzimidazole tetrasulfonate), drometrizole trisiloxane, and inorganic UV-absorbing particles (such as zinc oxide and titanium dioxide), or a mixture thereof. In one aspect, sunscreen(s) may be included in the cosmetic composition, as described herein, in an amount of from 1% to 20%, or from 2% to 10%, by weight of the composition.

[0057] Anti-irritants suitable for use in the invention include allantoin, aloe vera, a-bisabolol, caffeine, chamomile extract, Cola nitada extract, cucumber extract, dipotassium glycyrrhizinate, glycyrrhizic acid, green tea extract, lecithin or hydrogenated lecithin, licorice extract, tea tree oil, strontium acetate, strontium chloride, strontium nitrate, fatty acids with anti-irritant properties (such as linoleic acid and linolenic acid) and aromatic aldehydes with anti-irritant properties (such as 4-methoxy benzaldehyde, 4-ethoxy benzaldehyde, 4-butoxy benzaldehyde and 4- pentoxy benzaldehyde). In one aspect, mixtures and / or combinations of any of the abovedescribed materials may also be used. In one aspect, anti-irritants may be included in the cosmetic composition, as described herein, in an amount of from 0.1% to 20%, or from 0.5% to 15%, or from 0.75% to 10%, by weight of the composition.

[0058] Exfoliating agents suitable for use in the invention include benzoyl peroxide, benzoic acid, 3- hydroxy benzoic acid, salicylic acid, acetylsalicylic acid, acetic acid, trichloroacetic acid, 1- pyrrolidone-5-carboxylic acid, a-hydroxy acids (such as glycolic acid, lactic acid, malic acid, tartaric acid, mandelic acid, and citric acid); p-hydroxy acids (such as p-hydroxybutyric acid); a- keto acids (such as pyruvic acid, 2-oxopropanoic acid, 2-oxobutanoic acid and 2-oxopentanoic acid); and oxa acids (such as 3,6,9-trioxaundecanedioic acid). In one aspect, mixtures and / or combinations of any of the above-described materials may also be used. In one aspect, exfoliating agent(s) may be included in the cosmetic composition, as described herein, in an amount of from 0.001% to 12%, or from 0.001% to 10%, or from 0.01% to 8%, by weight of the composition.

[0059] Another optional skin care active suitable for use includes hemp oil with 2.5 to 25% by weight cannabigerol and / or cannabidiol at from 0.5% to 10% by weight. When used, such oil makes up from 0.0001% to 12%, or from 0.01% to 5% by weight of the cosmetic composition. In one embodiment, the cosmetic composition disclosed herein comprise (a) at least one skin care benefit agent, and (b) at least one skin care active comprising caffeine, ubiquinone, hydrolyzed rice protein, bisabolol, carnosine, Nannochloropsis Oculata extract, Gleditsia Triacanthos Seed extract, Zingiber Officinale (Ginger) Root extract, menthoxypropanediol, or a combination thereof. In another embodiment, the cosmetic composition further comprises at least one of a vitamin B3compound, a resorcinol compound, a sunscreen, or a combination thereof.

[0060] Functional Ingredients

[0061] In addition, the color stable cosmetic composition as described herein, may include additional functional ingredients.

[0062] Examples of additional functional ingredients which are suitable for use in the invention include water soluble or colloidally water soluble polymeric thickening agents (such as hydroxyethyl cellulose, methyl cellulose, hydroxypropyl methyl cellulose, polyquaternium-10, carrageenan, guar gum, hydroxypropyl guar gum, xanthan gum, polyvinylalcohol, pullulan, acrylic acid / ethyl acrylate copolymers, carboxyvinyl polymers, cross-linked polyacrylate polymers and polyacrylamide polymers); structurant clays (such as magnesium aluminium silicate, attapulgite, bentonite, montmorillonite and hectorite); inorganic pigments (such as titanium oxide, zirconium oxide, cerium oxide zinc oxide, iron oxide, chromium oxide and ferric blue); organic pigments (such as carbon black and barium, strontium, calcium, and aluminium lakes); pearlescent agents (such as mica and / or mica coated with titanium oxide and / or iron oxide); cooling agents (such as menthoxypropanediol); dyes, preservatives (such as EDTA, disodium EDTA, benzyl alcohol, methylparaben, sodium benzoate, phenoxyethanol, ethylhexylglycerin, 1 ,2-octanediol, iodopropynyl butyl carbamate (IPBC), hydroxyacetophenone, propylparaben, ethylparaben, butylparaben, and isobutylparaben); pH adjusters, and fragrances (including essential oils). In one aspect, mixtures and / or combinations of any of the above-described materials may also be used. In one aspect, the cosmetic composition is substantially free of parabens, having less than 5%, or less than 3%, or less than 1 %, or less than 0.5%, or less than 0.1 %, or 0.01 to 5%, or from 0.05 to 3%, or 0% of parabens. In one aspect, functional ingredient(s) may be included in the cosmetic composition, as described herein, in an amount of from 0.001% to 12%, or from 0.001% to 10%, or from 0.01 % to 8%, or from 0.02 to 6% by weight of the composition.

[0063] One of ordinary skill in the art would be adept to identify any need of neutralization, such as for adequate swelling of acrylate- based polymers to achieve a desirable and / or maximum viscosity. Any pH modifier known in the field acceptable for use in personal care and / or pharmaceutical products can be employed to result in a cosmetic composition possessing a skin-acceptable pH, typically within the range of from 4 to 8. In a preferred embodiment, the pH of the cosmetic composition is from 4.25 to 7.5, and most preferably, from 5 to 7. Traditional buffers or pH modifiers include common additives such as sodium hydroxide, potassium hydroxide, hydrochloric acid, citric acid, triethanolamine, and aminomethyl propanol. Viscosity of the cosmetic composition disclosed herein is preferably 1 ,000 to 120,000 mPas, and, more preferably, 5,000 to 80,000 mPas, taken under conditions of ambient temperature and a shear rate of 1s_1with a strain controlled parallel plate rheometer made commercially available from suppliers like T.A. Instruments under the Discovery name. Alternatively, viscosity can also be measured using a Brookfield Viscometer (speed at 20 rpm, spindle 5, helipath off, for one (1) minute at ambient temperature). The cosmetic composition can be formulated as a serum having a viscosity of 1 ,000 to 4,000 millipascal-second (mPas), a lotion having a viscosity of 4,000 to 10,000 mPas, a fluid cream having a viscosity of 10,000 to 20,000 mPas or a cream having a viscosity of 20,000 to 100,000 mPas or above.

[0064] When making the present cosmetic composition, the desired ingredients are mixed via conventional methods. If applicable, the oil phase and water phases are separately mixed using standard mixers and mixing blades and heated to a temperature usually from 20 to 85°C under atmospheric pressure. Upon reaching the desired temperature, the oil phase is added to the water phase to create an emulsion. Other ingredients in the cosmetic composition are subsequently added and mixed in no particular order.

[0065] The cosmetic composition disclosed herein is a composition suitable for topical application to human skin, including leave-on and wash-off products. Preferably, the term encompasses a fluid liquid, and particularly a moisturizer rather than a make-up product. Most preferred are leave-on compositions. The term "leave-on" as used with reference to compositions herein means a composition that is applied to or rubbed on the skin and left thereon.

[0066] Many types of packaging can be used to store and deliver the present cosmetic composition. The selection of packaging is dependent upon the cosmetic end-use and the viscosity of the composition itself. As an example, leave-on lotions and creams for skin typically employ plastic containers with an opening at a dispense end covered by an appropriate closure. Conventional closures include flip-top hinged lids, screw-caps, and non-aerosol pumps. As another example, appropriate packaging to be used for antiperspirants, deodorants and depilatories include a container with a roller-ball applicator on a dispensing end if the composition is fluid and of a thinner viscosity. If the composition is in a stick format, a container with a propel-repel mechanism wherein the stick is fixed on a platform towards a dispensing orifice is appropriate. If the composition is in an aerosol format, then metallic cans pressurized by a propellant and having a spray nozzle is appropriate. In general, patches, bottles, tubes, roller-ball applicators, squeeze containers, or lidded jars are preferred.

[0067] In one aspect, there is provided a method of reducing pollution-induced hyperpigmentation in skin comprising a step consistent in applying to the skin a composition comprising at least one skin care benefit agent and at least one compound of General Formula (1), preferably, tetrahydroxypropyl ethylenediamine.

[0068] In another aspect, there is provided a method of providing a skin benefit to skin comprising: (a) applying a cosmetic composition to the skin, wherein the cosmetic composition comprises at least one skin care benefit agent and at least one compound of General Formula (1), where Ri, R2, R3, R4 are each, independently, a linear or branched carbon chain having 2 to 6 carbon atoms; and Rs is a carbon chain having 1 to 6 carbon atoms; in a cosmetically acceptable base, wherein a weight ratio of the skin care benefit agent to the compound of General Formula (1) gent is present from 75:1 to 1 :75, preferably, from 65:1 to 1 :50, and, more preferably, from 55:1 to 1 :25.

[0069] In yet another aspect, there is provided a use of the cosmetic compositions disclosed herein for at least one skin care benefit, preferably, skin tone and / or skin texture, more preferably, for reducing pigmentation of skin.

[0070] The cosmetic compositions will now be described below in the context of specific non-limiting examples to facilitate a greater understanding of the present cosmetic compositions. One of ordinary skill in the art will recognize that variations of the inventive compositions that differ from the examples given may be practiced without deviating from the teachings of the present compositions.

[0071] The depigmenting effects of a combination comprising THPE and a skin care benefit agent were evaluated through an in vitro pollutant-induced model. The pollutant selected was chrysene, as made commercially available by Sigma-Aldrich. The skin care benefit agent selected was N-acetyl-DL-methionine as made commercially available by Evonik. The THPE selected was made commercially available by BASF. Darkly-pigmenting (DP) neonatal primary human melanocytes were sourced from Thermo Fisher Scientific. The melanocytes were maintained in Medium 254 supplemented with human Melanocyte Growth Supplement 2 (MGM, Cascade Biologicals) as well as with 10 ll / rnl penicillin G and 0.1 mg / ml streptomycin sulphate. The maintenance and sub-culturing of cells were carried out in the manner set forth in the manufacturer’s instructions. Cells between passages 3-6 were used for experimentation. Cells were maintained at a temperature of about 37°C and incubated in a humidified incubator with 5% CO2 atmosphere.

[0072] For the experiments, cells were seeded at a density of 5 x 104cells per well of a 24-well plate and maintained in a 5% CO2 incubator at about 37°C and 95% humidity for twenty-four (24) hours. Cultures were dosed with different concentrations of TH PE or acetyl methionine alone or in combination, and were challenged by the presence of 5 pg / ml chrysene. Seventy-two (72) hours later, culture supernatants were collected to determine cellular cytotoxicity by a Lactate Dehydrogenase (LDH) assay kit made commercially available by Invitrogen, while cultured cells were harvested and processed for estimation of melanin content using conventional techniques known to one skilled in the art.

[0073] Cellular cytotoxicity by LDH Assay

[0074] 30 pL of culture supernatant was collected from each treatment well and transferred to a 96-well plate. To determine maximum LDH, the lysis buffer provided in the LDH assay kit (10X) was added to the well containing cells in a 1 :10 dilution to enable release of maximum LDH from the cells. To the 30 pL of culture supernatant collected, 30 pL of a mixture of the LDH assay buffer and substrate solution was made based on the number of samples and added. The plate was incubated for thirty (30) minutes. Then, 30 pL of stop solution was added to stop the reaction. Once the reaction was stopped, the reading was recorded at a wavelength of 490 nm in a TECAN plate reader. After ascertaining non-cytotoxic doses, treatments were progressed for melanin estimation.

[0075] Melanin content estimation

[0076] After culture supernatants were collected and processed for cellular cytotoxicity by the LDH assay, adherent cells were lysed with a solution containing 1 N NaOH and 10% DMSO prepared in water and placed for one (1) hour at 60°C in a shaker incubator. The lysed cell suspension was cooled to room temperature (i.e. , about 20 to 25°C), mixed thoroughly, and transferred to a 384- well plate. Melanin content was measured at 405 nm in a TECAN plate reader. Melanin content was reported as % control ± SE.

[0077] Example 1:

[0078] Acetyl methionine and THPE were combined in different concentrations to evaluate impact on pollutant-induced melanin content in cultured primary human melanocytes. It was unexpectedly found that acetyl methionine and THPE synergistically reduced chrysene-induced melanin content only at specific dose combinations and weight ratios as captured in Tables 1, 2, and 3 of Example 1.

[0079] Table 1

[0080] Samples A, B, C, and D are comparative examples (not according to the invention) which are characterized by an absence of THPE, a skin care benefit agent, or a combination thereof. The untreated control in sample A was not treated with any treatment, including chrysene. Sample 1 comprises 0.0001 wt% THPE and 0.05 wt% acetyl methionine in the composition in accordance with the invention. Table 2

[0081] Samples A, B, E, and F are comparative examples (not according to the invention) which are characterized by an absence of THPE, a skin care benefit agent, or a combination thereof.

[0082] Sample 2 comprises 0.002 wt% THPE and 0.02 wt% acetyl methionine in the composition in accordance with the invention.

[0083] Table 3 P0000896WG CPL

[0084] 23

[0085] Samples A, B, G, and H are comparative examples (not according to the invention) which are characterized by an absence of TH PE, a skin care benefit agent, or a combination thereof. Sample 3 comprises 0.0002 wt% THPE and 0.002 wt% acetyl methionine in the composition in accordance with the invention.

[0086] 5

[0087] Example 2: Sample Formulation

[0088] The following ingredients were mixed under conditions of moderate sheer, 20°C to 85°C, and atmospheric pressure to produce the resulting emulsion cosmetic composition.

[0089] 10

[0090] An emulsion cosmetic composition according to the invention was made by combining the above ingredients.

Claims

P0000896WG GPL24Claims1. A cosmetic composition comprising: a) at least one skin care benefit agent, and b) at least one compound of General Formula (1):where Ri, R2, R3, R4 are each, independently, a linear or branched carbon chain having2 to 6 carbon atoms; and Rs is a carbon chain having 1 to 6 carbon atoms; in a cosmetically acceptable vehicle; and wherein the skin care benefit agent is acetyl glutamic acid, acetyl glutamine, acetyl methionine, acetyl tyrosine, or a derivative, salt, or combination thereof.

2. The cosmetic composition according to claim 1 , wherein the compound of General Formula (1) is selected from N,N,N',N'-tetrakis(2-hydroxyethyl)ethylenediamine (THEED), tetrahydroxypropyl ethylenediamine (THPE), and N,N,N',N'-tetrakis(2- hydroxypentyl)ethylenediamine.

3. The cosmetic composition according to claim 1 or 2, wherein the compound of General Formula (1) is tetrahydroxypropyl ethylenediamine.

4. The cosmetic composition according to any of the preceding claims, wherein the skin care benefit agent is, acetyl methionine, acetyl tyrosine, or a derivative, salt, or combination thereof, more preferably, acetyl methionine.

5. The cosmetic composition according to any of the preceding claims, wherein the skin care benefit agent is present in the cosmetic composition disclosed herein in an amount of from 0.0001 to 10%, preferably, from 0.0005 to 8%, and, more preferably, from 0.001 to 6% by weight of the cosmetic composition.P0000896WG GPL256. The cosmetic composition according to any of the preceding claims, wherein the cosmetic composition comprises from 0.00001 to 10%, preferably, from 0.0001 to 7.5%, and, more preferably, from 0.0001 to 5% by weight of a compound having General Formula (1).

7. The cosmetic composition according to any of the preceding claims, wherein the skin care benefit agent to the compound of General Formula (1) is present in a weight ratio of from 75:1 to 1 :75, preferably, from 65:1 to 1 :50, and, more preferably, from 55:1 to 1 :25.

8. The cosmetic composition according to any of the preceding claims, wherein the skin care benefit agent to the compound of General Formula (1) is present in a weight ratio of from 60:1 to 1 :0.5, preferably, from 60:1 to 1 :1 , and, more preferably, from 55:1 to 5:1.

9. The cosmetic composition according to any of the preceding claims, wherein the cosmetically acceptable vehicle comprises at least 40% by weight aqueous phase.

10. The cosmetic composition according to any of the preceding claims further comprising at least one skin care active and / or functional ingredient.

11. A cosmetic composition comprising: a) at least one skin care benefit agent, and b) at least one skin care active comprising caffeine, ubiquinone, hydrolyzed rice protein, bisabolol, carnosine, Nannochloropsis Oculata extract, Gleditsia Triacanthos Seed extract, Zingiber Officinale (Ginger) Root extract, menthoxypropanediol, or a combination thereof; wherein the skin care benefit agent is acetyl glutamic acid, acetyl glutamine, acetyl methionine, acetyl tyrosine, or a derivative, salt, or combination thereof.

12. The cosmetic composition according to claim 11 , wherein the cosmetic composition further comprises at least one of a vitamin B3 compound, a resorcinol compound, a sunscreen, or a combination thereof.

13. The cosmetic composition according to claim 11 or 12, wherein the skin care benefit agent is acetyl methionine, acetyl tyrosine, or a derivative, salt, or combination thereof, and, more preferably, acetyl methionine.P0000896WG GPL2614. Use of the cosmetic composition according to any of the preceding claims for at least one skin care benefit, preferably, skin tone and / or skin texture, more preferably, for reducing pigmentation of skin.

15. A method of providing a skin benefit to skin comprising: a) applying a cosmetic composition to the skin, wherein the cosmetic composition comprises at least one skin care benefit agent and at least one compound of General Formula (1):where Ri, R2, R3, R4 are each, independently, a linear or branched carbon chain having 2 to 6 carbon atoms; and Rs is a carbon chain having 1 to 6 carbon atoms; in a cosmetically acceptable base; wherein a weight ratio of the skin care benefit agent to the compound of General Formula (1) is present from 75:1 to 1 :75, preferably, from 65:1 to 1 :50, and, more preferably, from 55:1 to 1 :25; and further wherein the skin care benefit agent is acetyl glutamic acid, acetyl glutamine, acetyl methionine, acetyl tyrosine, or a derivative, salt, or combination thereof.

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