A home care cleaning composition for delivering benefits to skin

Abstract

The present invention relates to a composition for providing skin health through a home care cleaning composition. When formulated as a laundry treatment composition the actives included therein are delivered to the fabric being laundered so that the person wearing the fabrics after laundering gets the benefits delivered on to the skin. The actives may also be delivered directly to the skin when the composition is used for laundering clothes by hand or when washing dishes with a hand dish wash composition of the invention. The actives are two specific polysaccharides pectin and resistant maltodextrin.

Description

[0001] P0001010 CPL

[0002] 1

[0003] A HOME CARE CLEANING COMPOSITION FOR DELIVERING BENEFITS TO SKIN

[0004] Field of the Invention

[0005] 5 The present invention relates to a composition for delivering skin health. Particularly, the present invention relates to a laundry treatment composition that delivers the actives included therein to the fabric being laundered so that the person wearing the fabrics after laundering gets the benefits on to the skin which is in contact with laundered fabric. The actives may also be delivered through a cleaning composition like a laundry hand wash composition, or a hand dishwash composition such that when the composition is used to clean the desired surface using ones hands, the benefits of the invention are delivered to the skin surface which comes in contact with the composition.

[0006] Background of the Invention

[0007] 15 Washing fabrics, also known as laundering or simply as laundry, makes up one of the main chores that people undertake routinely. Laundering is undertaken primarily to remove noticeable stains which may be oily, particulate or food stains. Clothes are also laundered to remove malodour and give them a fresh look and smell. For this, people have been relying on detergent compositions that are widely available. Typically, a fabric is washed by contacting it with a

[0008] 20 detergent composition either in neat or diluted form, rinsing the fabric one or more times with water; and finally, drying it.

[0009] Many other actives are included in detergent compositions to deliver various other benefits like softness and conditioning benefits, antimicrobial benefits, anti-wrinkling benefits, sun-screening

[0010] 25 benefits etc. Although some attempts have been made to deliver skin care benefits through detergent compositions that are used to wash clothes worn by people, it is still a vastly unexplored area. The present inventors through their extensive experience in biochemistry of skin and the interfacial science of cleaning, conducted extensive experimentation with various actives that could be included into detergent composition to deliver perceptible skin benefits. To their surprise

[0011] 30 they found that two very commonly used polysaccharides pectin and resistant dextrin when included in a detergent composition upregulate two different genes which work in tandem to deliver skin health benefits. They also believe that this technology which uses commonly available and safe polysaccharides for improving skin health is a sustainable technology. P0001010 CPL

[0012] 2

[0013] Since the composition delivers the benefits on to skin through a wash off composition, it was found to be effective whenever the skin comes in contact with a wash liquor containing the composition like in the case of a hand wash laundry composition and a hand dish-wash composition.

[0014] 5

[0015] It is therefore an object of the present invention to provide for a laundry treatment composition that delivers skin care benefits to the person wearing the clothes laundered with the composition.

[0016] Summary of the Invention

[0017] The first aspect of the present invention relates to a home care cleaning composition for delivering benefits to skin comprising

[0018] (i) 0.001 to 10 wt% pectin;

[0019] (ii) 0.001 to 10 wt% resistant dextrin; and

[0020] (iii) a surface treatment active selected from one or both of a surfactant or a fabric softening

[0021] 15 active.

[0022] According to another aspect of the present invention there is provided a method of delivering skin health to a person wearing a laundered fabric wherein the laundry process comprises the steps of (i) contacting the fabric pre-wet with water with a composition of the first aspect; (ii) rinsing the

[0023] 20 fabric with water; and (ii) drying the rinsed fabric.

[0024] Detailed Description of the Invention

[0025] For the avoidance of doubt, any feature of one aspect of the present invention may be utilised in any other aspect of the invention. The word "comprising" is intended to mean "including" but not

[0026] 25 necessarily "consisting of” or "composed of". Thus, the term "comprising" is meant not to be limiting to any subsequently stated elements, but rather to optionally also encompass nonspecified elements of major or minor functional importance. In other words, the listed steps or options need not be exhaustive. Whenever the words "including" or "having" are used, these terms are meant to be equivalent to "comprising" as defined above. It is noted that the examples given in the description below are intended to clarify the invention and are not intended to limit the invention to those examples per se. Except in the examples, or where otherwise explicitly indicated, all numbers in this description indicating amounts of material or conditions of reaction, physical properties of materials and / or use are to be understood as modified by the word "about". Unless specified otherwise, numerical ranges expressed in the format "x to y" are understood to

[0027] 35 include x and y. When for a specific feature multiple preferred ranges are described in the format P0001010 CPL

[0028] 3

[0029] "x to y", it is understood that all ranges combining the different endpoints are also contemplated. Unless specified otherwise, amounts as used herein are expressed in percentage by weight based on total weight of the composition and is abbreviated as “wt%”.

[0030] 5 The composition of the invention delivers improved skin health through use of a home care cleaning composition like a laundry detergent composition or a fabric conditioning composition which are both used to clean clothes and other laundry articles. The laundered clothes after they are dried are used by the consumer. The fabric of the clothes so laundered when in touch with the skin during use by the consumer are seen to deliver the skin health. The skin health is also seen to be delivered to the hands of the person when he or she uses the laundry detergent composition or the fabric conditioning composition to wash the clothes by hand.

[0031] The skin health benefits of the composition of the invention is also delivered to the hands of the person who washes dishes using the hand dish wash composition of the invention.

[0032] The skin health benefits through use of the composition of the invention includes reduced water

[0033] 15 loss though the skin thereby keeping the skin less dry and so better hydrated. Concomitantly the skin is less prone to entry of foreign particles like allergens thus improving the defence mechanism of the skin. The benefits also include a more balanced microbiome on the skin.

[0034] The composition of the invention comprises pectin. Pectin is a structural

[0035] 20 acidic heteropolysaccharide contained in the primary and middle lamella and cell walls of terrestrial plants. Its main component is galacturonic acid, a sugar acid derived from galactose. It is produced commercially as a white to light brown powder, mainly extracted from citrus fruits, and is used in food as a gelling agent, particularly in jams and jellies. It is also used in dessert fillings, medicines, sweets, as a stabiliser in fruit juices and milk drinks, and as a

[0036] 25 source of dietary fibre. Pectin also known as pectic polysaccharides, are rich in galacturonic acid. Several distinct polysaccharides have been identified and characterised within the pectic group. Homogalacturonans are linear chains of a-(1— 4)-linked D-galacturonic acid. Substituted galacturonans are characterised by the presence of saccharide appendant residues (such as D- xylose or D-apiose in the respective cases of xylogalacturonan and apiogalacturonan) branching

[0037] 30 from a backbone of D-galacturonic acid residues. Rhamnogalacturonan pectins (RG-I) contain a backbone of the repeating disaccharide: 4)-a-D-galacturonic acid-(1 ,2)-a-L-rhamnose-(1. From many of the rhamnose residues, sidechains of various neutral sugars branch off. The neutral sugars are mainly D-galactose, L-arabinose and D-xylose, with the types and proportions of neutral sugars varying with the origin of pectin. Another structural type of pectin P0001010 CPL is rhamnogalacturonan II (RG-II), which is a less frequent, complex, highly branched polysaccharide.

[0038] Pectin is preferably derived from one or more of a fruit chosen from pear, apple, guava, plum,

[0039] 5 gooseberry, orange or any other citrus fruit, preferably citrus. It is preferably from apple or citrus fruit. It is preferred that the pectin included in the composition of the invention is in free form i.e. it is not delivered through the shells of microcapsules included in the composition. It is also preferred that the composition of the invention is not delivered through wipes. By wipes is meant a porous water - insoluble substrate into which the composition is impregnated.

[0040] Pectin consists predominantly of a-D galacturonic acid units, but also contains some amount of neutral sugars such as rhamnose, xylose, arabinose, galactose and glucose.

[0041] The percentage of galacturonic acid units is therefore the amount of galacturonic acid groups present relative to the total amount of the pectin. The galacturonic acid content of a sample can

[0042] 15 be determined by methods known in the art, such as for example the Saeman hydrolysis method (Englyst and Cummings (Analyst, 109(7), 937-942 (1984), Filisetti-Cozzi and Carpita (Analytical Biochemistry, 197, 157-162 (1991)).

[0043] Galacturonic acid typically has the following repeat unit structure:

[0044] 20

[0045] It is possible to esterify galacturonic acids on the carboxylic acid group. The percentage of esterified units is called the degree of esterification (DE). The degree of esterification can be determined according to methods known in the art, such as the base titration method (Shultz,

[0046] 25 1965) as proposed by the Food Chemical Codex (FCC (1981). 3rd ed., (1981) National Academy of Science, Washington, DC), quantification of methanol released during de-esterification using gas chromatography (GC) (Walter et al. (1983), Journal of Food Science, 48: 1006-10070), colorimetry (Hou et al. (1999), Botanical Bulletin of Academia Sincia, 40:115-119), high performance liquid chromatography (HPLC) (Levigne S., et al. (2002), Food Hydrocolloids 16:

[0047] 30 547-550), nuclear magnetic resonance (NMR) (Rosenbohm et al. (2003) Carbohydrate Research, 338: 637-649) and capillary zone electrophoresis (CZE) (Williams et al. (2003), Journal of Agricultural Food and Chemistry, 51 : 1777-1781). P0001010 CPL

[0048] 5

[0049] A method to separate pectin into fractions with different DE is described, for example, by Strom, et al. (2005), Carbohydrate Polymers, Volume 60, Issue 4, 20 June 2005, Pages 467-473.

[0050] In nature, the carboxylic groups are typically methylated to varying degrees to provide pectin methyl esters. The number fraction of carboxylic acid groups methylated is known as the degree

[0051] 5 of methyl esterification.

[0052] The pectin used in the composition of the present invention preferably has a degree of methyl esterification higher than 50%, more preferably 52.5% or higher, further more preferably 55% or higher, yet more preferably 57.5% or higher and most preferably 60% or higher.

[0053] The pectin used according to the invention preferably has a molecular weight of higher than 50kDa, more preferably higher than 100kDa. Typical upper limits of pectin molecular weights are preferably of the order of 1000kDa, more preferably 800kDa. Thus, the pectin for use in the composition of the invention preferably has a molecular weight of between 50 kDa and 1000kDa.

[0054] 15 The composition comprises pectin to be included at a concentration of 0.001 to 10%, preferably 0.01 to 5%, more preferably 0.1 to 3%, further more preferably 0.1 to 2% by weight of the composition.

[0055] The composition of the invention comprises resistant dextrin. Resistant dextrin is also known by

[0056] 20 some as digestion resistant maltodextrin. It is usually prepared by highly controlled partial hydrolysis of corn, potatoes, barley or wheat preferably from corn starch. It usually contains 3 to 20 D-glucose units that are linked by a(1 -4), a(1 -6), p(1 -4) and p(1 -6) glycosidic bond. It is also reported to contain some 1 ,2 and 1 ,3 glycosidic bond. It usually has the chemical formula C6nH( n+2)O(5n+i) or (CeHioOsjn where ‘n’ represents the number of glucose units linked together.

[0057] 25 It is usually sold as an off-white powder which is odourless. It is soluble in water. A preferred supplier of resistant dextrin is ADM Bio Science & Technology (Tianjin) Co. Ltd., Tianjin, China who sell it under the brand name Fibersol or FibersolR2. Resistant dextrin is included in 0.001 to 10%, preferably 0.01 to 5%, more preferably 0.1 to 3%, further more preferably 0.1 to 2% by weight of the composition.

[0058] 30

[0059] For the sake of clarity, the resistant dextrin referred herein is not what is generally known as maltodextrin (or digestible maltodextrin) which predominantly contains only a(1-4) glycosidic bonds. P0001010 CPL

[0060] 6

[0061] Without wishing to be bound by theory the inventors believe that the pectin and resistant dextrin delivered to the skin via the laundered fabric upregulate certain genes on the skin that work in tandem to deliver better skin health. They believe that these two polysaccharides act on the skin and improve skin health by selectively turning on genes which are involved in skin regeneration,

[0062] 5 maintenance, and desquamation. They work alone or in tandem especially when they turn on different genes. The present inventors have shown that there is benefit in both solo or combination modes. In combination, pectin and resistant dextrin are seen to work in tandem to deliver enhanced benefit. While they can turn on beneficial genes by themselves, the net effect of turning on genes which are upstream and downstream together makes it more powerful. Pectin turns on KLK5 and resistant dextrin in combination with Pectin turns on Involucrin, Loricrin and Filaggrin. KLK5 is a protease and Involucrin is a substrate for the protease. Together this results in enhanced benefit.

[0063] The composition of the invention preferably comprises a hydrotrope. Suitable hydrotropes for

[0064] 15 inclusion in the composition of the invention are one or more of an alkali metal cumene sulphonate, alkali metal xylene sulphonate, polyethylene glycol (PEG), mono propylene glycol (MPG), and dipropylene glycol (DPG). The preferred alkali metal cumene sulphonate is sodium cumene sulphone (SOS). The preferred alkali metal xylene sulphonate is sodium xylene sulphonate (SXS). The most preferred hydrotrope for use in the present invention is one or both

[0065] 20 of SOS and MPG. The composition preferably comprises 0.05% to 5 wt%, more preferably 0.1 to 4 wt% hydrotrope.

[0066] It is especially preferred that the composition of the invention includes a preservative.

[0067] 25 It is further preferred that the composition of the invention includes a fragrance. Fragrance is also referred to as a fragrance component, a perfume or a perfume component and so these words / phrases are used interchangeably. Perfume components may comprise odiferous materials and / or pro-fragrance materials. The cleaning composition preferably comprises 0.1 to 15 wt.% perfume, more preferably 0.5 to 8 wt. % free perfume.

[0068] Particularly preferred perfume components are blooming perfume components and substantive perfume components. Blooming perfume components are defined by a boiling point less than 250°C and a LogP or greater than 2.5. Substantive perfume components are defined by a boiling point greater than 250°C and a LogP greater than 2.5. Boiling point is measured at standard

[0069] 35 pressure (760 mm Hg). Preferably a perfume composition will comprise a mixture of blooming P0001010 CPL

[0070] 7 and substantive perfume components. The perfume composition may comprise other perfume components.

[0071] The composition of the invention is useful in cleaning and treating surfaces in home care

[0072] 5 applications. A "home care cleaning composition" as per this invention is a product for the treatment, cleaning, caring or conditioning of soft and hard surfaces in the home which are cleaned by hand. The foregoing includes products for cleaning or conditioning of surfaces, clothes and fabrics and for cleaning dishes with hand.

[0073] 10 The composition may be delivered as a laundry detergent composition which in addition to the two polysaccharides also includes 1 to 80% surfactant. The laundry detergent composition may be delivered in the form of a solid or as a liquid of which the liquid form is more preferred. A preferred aspect relates to a laundry detergent composition which comprises 5 to 60% anionic surfactant.

[0074] 15

[0075] The solid laundry compositions herein can take a variety of physical solid forms including forms such as powder, granule, ribbon, noodle, paste, tablet, flake, pastille and bar, and preferably the composition is in the form of powder, granule or a bar. The composition according to the present invention may be made via a variety of conventional methods known in the art including dry¬

[0076] 20 mixing, compaction such as agglomerating, extrusion, tabletting, or spray-drying of the various compounds comprised in the detergent component, or combinations of these techniques. The powder or granule compositions preferably have a density of more than 350 grams / litre, more preferably more than 450 grams / litre or even more than 570 grams / litre.

[0077] 25 Typical solid laundry detergent compositions comprise one or more of surfactants chosen from anionic, nonionic, zwitterionic, cationic, amphoteric types, preferably it is of the anionic type. These compositions in solid form typically comprise from 2 to 30% by weight surfactants. They may also comprise other adjuvents to provide benefits to the fabric being washed e.g soil release polymers and antiredeposition polymers which together may be included in 0 to 5% by weight of

[0078] 30 the composition. Builders are generally included especially to counteract the ill effects of hardness of water being used to wash the fabric and these account for up to 50% typically 10 to 30% by weight of the composition. Other fabric benefit agents like shading dyes and optical brightener may be included in up to 1 % by weight of the composition. Bleaches may sometimes be included and when it is included it accounts for up to 10% by weight of the composition and

[0079] 35 fillers generally account for up to 40% by weight of the composition. P0001010 CPL

[0080] 8

[0081] The solid laundry detergent composition according to the present invention preferably has a pH from 7.0 to 10.5, preferably 7.0 to 10.2, still preferably from 8.5 to 10.2, when measured at 1 wt.% dilution in de-ionised water at 25°C. The composition may preferably include a buffer.

[0082] 5 The laundry detergent composition in which the present invention may be delivered in the liquid form. The term liquid may encompass emulsions, suspensions, and compositions having flowable yet stiffer consistency, known as gels or pastes. Pourable liquid detergent compositions preferably have a viscosity of from 200 to 1 ,500 mPa.s, preferably from 200 to 700 mPa.s. Such compositions generally have an aqueous continuous phase. Preferably, the composition comprises at least 50% wt. water and more preferably at least 70% wt. water. Water is generally present in an amount of 20% to 99.9% preferably from 40% to 80% by weight of the composition.

[0083] Liquid laundry detergent compositions generally comprise 5 to 60% and preferably from 10 to 40% by weight of one or more surfactants. The surfactant is generally anionic in nature.

[0084] 15 Preferred anionic surfactants are of the organic sulfates and sulfonates having alkyl radicals containing from about 8 to about 22 carbon atoms, the term “alkyl” being used to include the alkyl portion of higher acyl radicals. Examples of such materials include alkyl sulfates, alkyl ether sulfates, alkaryl sulfonates, alpha-olefin sulfonates and mixtures thereof. The alkyl radicals preferably contain from 10 to 18 carbon atoms and may be unsaturated. The alkyl ether sulfates

[0085] 20 may contain from one to ten ethylene oxide or propylene oxide units per molecule, and preferably contain one to three ethylene oxide units per molecule. The counterion for anionic surfactants is generally an alkali metal such as sodium or potassium; or an ammoniacal counterion such as monoethanolamine, (MEA) diethanolamine (DEA) or triethanolamine (TEA). Mixtures of such counterions may also be employed. Sodium and potassium are preferred.

[0086] 25

[0087] Most preferred surfactants are of the alkylbenzene sulfonates type, particularly linear alkylbenzene sulfonates (LAS) with an alkyl chain length of from 10 to 18 carbon atoms. Some alkyl sulfate surfactant (PAS) may be used, such as non-ethoxylated primary and secondary alkyl sulphates with an alkyl chain length of from 10 to 18.

[0088] Preferably, the composition comprises from 1 to 20%, more preferably 5 to 20 wt% non-ionic surfactant based on the total weight of composition. A preferred class of nonionic surfactant for use in the invention includes aliphatic Cs to Cis, more preferably C12 to C15 primary linear alcohol ethoxylates with an average of from 3 to 20, more preferably from 5 to 10 moles of ethylene oxide per mole of alcohol. A preferred non-ionic surfactant are the C16 / 18 Alcohol ethoxylates.

[0089] 35 P0001010 CPL

[0090] 9

[0091] Liquid laundry detergent compositions also generally comprise agents like soil release polymers, hydrotropes, co-surfactants, builders, polymeric thickeners, and shading dyes in addition to the above described ingredients. Soil release polymers (SRP) help to improve the detachment of soils from fabric by modifying the fabric surface during washing. The SRP structure may also

[0092] 5 include capping groups to control molecular weight or to alter polymer properties such as surface activity. Preferred SRPs for use in the invention include copolyesters formed by condensation of terephthalic acid ester and diol, preferably 1 ,2 propanediol, and further comprising an end cap formed from repeat units of alkylene oxide capped with an alkyl group. The SRP, when included, may range from 0.1 to 10%, desirably from 0.3 to 7%, more preferably from 0.5 to 5% by weight of the composition.

[0093] The liquid laundry detergent composition of the invention may contain one or more cosurfactants (such as amphoteric (zwitterionic) and / or cationic surfactants) in addition to the non-soap anionic and / or nonionic detersive surfactants described above. Such cosurfactant, when included, may

[0094] 15 be present in an amount ranging from 0.1 to 5% by weight of the composition.

[0095] The liquid laundry detergent composition may also optionally contain relatively low levels of organic detergent builder or sequestrant material. Examples include the alkali metal citrates, succinates, malonates, carboxymethyl succinates, carboxylates, polycarboxylates

[0096] 20 aminocarboxylates and polyacetyl carboxylates. If utilized, the organic builder materials may comprise from about 0.5 percent to 20 wt percent, preferably from 1 wt percent to 10 wt percent, of the composition.

[0097] The composition of the invention is also preferably delivered as a fabric conditioning

[0098] 25 composition which additionally comprises 1 to 50% of a fabric softening active.

[0099] When the composition of the invention is delivered as a fabric conditioner composition, the fabric treatment active is a fabric softening active. Fabric conditioner composition generally comprises 1 to 50 wt. %, preferably 1.5 to 30 wt.% and more preferably 2 to 20 wt. % fabric softening active

[0100] 30 by weight of the composition. The fabric softening actives may be any material known to soften fabrics. These may be polymeric materials or compounds known to soften materials. Examples of suitable fabric softening actives include: quaternary ammonium compounds, silicone polymers, clays, amines, fatty esters, dispersible polyolefins, polymer latexes and mixtures thereof. P0001010 CPL

[0101] 10

[0102] The fabric softening actives may preferably be cationic or non-ionic materials. Preferably, the fabric softening actives of the present invention are cationic materials. Suitable cationic fabric softening actives are described herein.

[0103] 5 The preferred softening actives for use in fabric conditioner compositions of the invention are quaternary ammonium compounds (QAC).

[0104] The QAC preferably comprises at least one chain derived from fatty acids, more preferably at least two chains derived from a fatty acids. Generally fatty acids are defined as aliphatic monocarboxylic acids having a chain of 4 to 28 carbons. Fatty acids may be derived from various sources such as tallow or plant sources. Preferably the fatty acid chains are derived from plants. Preferably the fatty acid chains of the QAC comprise from 10 to 50 wt. % of saturated C18 chains and from 5 to 40 wt. % of monounsaturated C18 chains by weight of total fatty acid chains. In a further preferred embodiment, the fatty acid chains of the QAC comprise from 20 to 40 wt. %,

[0105] 15 preferably from 25 to 35 wt. % of saturated C18 chains and from 10 to 35 wt. %, preferably from 15 to 30 wt. % of monounsaturated C18 chains, by weight of total fatty acid chains.

[0106] The preferred quaternary ammonium fabric softening actives for use in compositions of the present invention are ester linked quaternary ammonium compounds or so called "ester quats".

[0107] 20

[0108] Particularly preferred materials are the ester-linked triethanolamine (TEA) quaternary ammonium compounds comprising a mixture of mono-, di- and tri-ester linked components.

[0109] Typically, TEA-based fabric softening compounds comprise a mixture of mono, di- and tri ester

[0110] 25 forms of the compound where the di-ester linked component comprises no more than 70 wt.% of the fabric softening compound, preferably no more than 60 wt.% e.g. no more than 55%, or even no more that 45% of the fabric softening compound and at least 10 wt.% of the monoester linked component.

[0111] 30 A first group of quaternary ammonium compounds (QACs) suitable for use in the present invention is represented by formula (I): P0001010 CPL

[0112] 11

[0113] [(CH;)rl(TR)]m wherein each R is independently selected from a C5 to C35 alkyl or alkenyl group; R1 represents a C1 to C4 alkyl, C2 to C4 alkenyl or a C1 to C4 hydroxyalkyl group; T may be either O-CO. (i.e. an ester group bound to R via its carbon atom), or may alternatively be CO-O (i.e. an ester group

[0114] 5 bound to R via its oxygen atom); n is a number selected from 1 to 4; m is a number selected from 1 , 2, or 3; and X- is an anionic counter-ion, such as a halide or alkyl sulphate, e.g. chloride or methylsulfate. Di-esters variants of formula I (i.e. m = 2) are preferred and typically have mono- and tri-ester analogues associated with them. Such materials are particularly suitable for use in the present invention.

[0115] Also suitable are actives rich in the di-esters of triethanolammonium methylsulfate, otherwise referred to as "TEA ester quats".

[0116] A second group of QACs suitable for use in the invention is represented by formula (II):

[0117] (R NHCH?CH-TR?X- (ir)

[0118] 15 wherein each R1 group is independently selected from C1 to C4 alkyl, hydroxyalkyl or C2 to C4 alkenyl groups; and wherein each R2 group is independently selected from C8 to C28 alkyl or alkenyl groups; and wherein n, T, and X- are as defined above.

[0119] 20 Preferred materials of this second group include 1 ,2 bis[tallowoyloxy]-3- trimethylammonium propane chloride, 1 ,2 bis[hardened tallowoyloxy]-3- trimethylammonium propane chloride, 1 ,2- bis[oleoyloxy]-3-trimethylammonium propane chloride, and 1 ,2 bis[stearoyloxy]-3- trimethylammonium propane chloride. Such materials are described in US 4, 137,180 (Lever Brothers). Preferably, these materials also comprise an amount of the corresponding mono-ester.

[0120] 25 A third group of QACs suitable for use in the invention is represented by formula (III): P0001010 CPL

[0121] 12 wherein each R1 group is independently selected from C1 to C4 alkyl, or C2 to C4 alkenyl groups; and wherein each R2 group is independently selected from C8 to C28 alkyl or alkenyl groups; and n, T, and X- are as defined above. Preferred materials of this third group include bis(2- tallowoyloxyethyl)dimethyl ammonium chloride, partially hardened and hardened versions

[0122] 5 thereof.

[0123] A particular example of the third group of QACs is represented the by the formula:

[0124] A fourth group of QACs suitable for use in the invention are represented by formula (V)

[0125] R1 and R2 are independently selected from C10 to C22 alkyl or alkenyl groups, preferably C14 to C20 alkyl or alkenyl groups. X- is as defined above.

[0126] The iodine value of the quaternary ammonium fabric conditioning material is preferably from 0 to

[0127] 15 80, more preferably from 0 to 60, and most preferably from 0 to 45. The iodine value may be chosen as appropriate. Essentially saturated material having an iodine value of from 0 to 5, preferably from 0 to 1 may be used in the compositions of the invention. Such materials are known as "hardened" quaternary ammonium compounds.

[0128] 20 A further preferred range of iodine values is from 20 to 60, preferably 25 to 50, more preferably from 30 to 45. A material of this type is a "soft" triethanolamine quaternary ammonium compound, preferably triethanolamine di-alkylester methylsulfate. Such ester-linked triethanolamine quaternary ammonium compounds comprise unsaturated fatty chains.

[0129] 25

[0130] A further type of softening compound may be a non-ester quaternary ammonium material represented by formula (VI): P0001010 CPL

[0131] 13 wherein each R1 group is independently selected from C1 to C4 alkyl, hydroxyalkyl or C2 to C4 alkenyl groups; R2 group is independently selected from C8 to C28 alkyl or alkenyl groups, and X- is as defined above.

[0132] 5 The fabric conditioner composition preferably comprises one or more cationic polymers more preferably 0.1 to 10 wt. % cationic polymer by weight of the formulation, even more preferably 0.2 to 7.5 wt. %, and most preferably 0.3 to 5 wt. % cationic polymer by weight of the formulation.

[0133] Cationic polymer refers to polymers having an overall positive charge. The cationic polymer may be naturally derived or synthetic. Examples of suitable cationic polymers include: acrylate polymers, cationic amino resins, cationic urea resins, cationic proteins and cationic polysaccharides.

[0134] Preferably the cationic charge of the cationic polymer is provided by the incorporation a

[0135] 15 quaternary ammonium salt. In other words, preferably the cationic polymer comprises a quaternary ammonium group. Preferably the quaternary ammonium salt is linked to the polysaccharide backbone by a hydroxyethyl or hydroxypropyl group. Preferably the charged nitrogen of the quaternary ammonium salt has one or more alkyl group substituents.

[0136] 20 The counterion of the cationic polymer is freely chosen from the halides: chloride, bromide, and iodide; or from hydroxide, phosphate, sulphate, hydrosulphate, ethyl sulphate, methyl sulphate, formate, and acetate.

[0137] The molecular weight of the cationic polymer is preferably greater than 20 000 g / mol, more

[0138] 25 preferably greater than 25 000 g / mol. The molecular weight is preferably less than 2 000 000 g / mol, more preferably less than 1 000 000 g / mol.

[0139] Polysaccharide based cationic polymers include cationic celluloses, cationic guars and cationic starches. Polysaccharides are polymers made up from monosaccharide monomers joined

[0140] 30 together by glycosidic bonds. P0001010 CPL

[0141] 14

[0142] Examples of suitable polysaccharide polymers are salts of hydroxyethyl cellulose reacted with trimethyl ammonium substituted epoxide, referred to in the field under the International Nomenclature for Cosmetic Ingredients as Polyquatemium 10 and is commercially available from the Amerchol Corporation, a subsidiary of The Dow Chemical Company, marketed as the

[0143] 5 Polymer LR, JR, and KG series of polymers.

[0144] Other suitable cationic polymers include Polyquatemium 24, cocodimethylammonium hydroxypropyl oxyethyl cellulose, lauryldimethylammonium hydroxypropyl oxyethyl cellulose, stearyldimethylammonium hydroxypropyl oxyethyl cellulose, and stearyldimethylammonium hydroxyethyl cellulose; cellulose 2-hydroxyethyl 2- hydroxy 3-(trimethyl ammonio) propyl ether salt, polyquaternium-4, polyquaternium-10, polyquaternium-24, polyquaternium-37 and polyquaternium-67 or mixtures thereof.

[0145] Non-polysaccharide-based cationic polymers are comprised of structural units, these structural

[0146] 15 units may be non-ionic, cationic, anionic or mixtures thereof. The polymer may comprise noncationic structural units, but the polymer must have a net cationic charge.

[0147] The cationic polymer may comprise a nonionic structural units derived from monomers selected from: (meth)acrylamide, vinyl formamide, N, N-dialkyl acrylamide, N, N-dialkylmethacrylamide,

[0148] 20 01-012 alkyl acrylate, 01-012 hydroxyalkyl acrylate, polyalkylene glyol acrylate, 01-012 alkyl methacrylate, 01-012 hydroxyalkyl methacrylate, polyalkylene glycol methacrylate, vinyl acetate, vinyl alcohol, vinyl formamide, vinyl acetamide, vinyl alkyl ether, vinyl pyridine, vinyl pyrrolidone, vinyl imidazole, vinyl caprolactam, and mixtures thereof.

[0149] 25 The cationic polymer may comprise a cationic structural units derived from monomers selected from: N, N-dialkylaminoalkyl methacrylate, N, N-dialkylaminoalkyl acrylate, N, N-dialkylaminoalkyl acrylamide, N, N-dialkylaminoalkylmethacrylamide, methacylamidoalkyl trialkylammonium salts, acrylamidoalkylltrialkylamminium salts, vinylamine, vinylimine, vinyl imidazole, quaternized vinyl imidazole, diallyl dialkyl ammonium salts, and mixtures thereof.

[0150] 30

[0151] Preferably, the cationic monomer is selected from: diallyl dimethyl ammonium salts (DADMAS), N, N-dimethyl aminoethyl acrylate, N,N-dimethyl aminoethyl methacrylate (DMAM), [2- (methacryloylamino)ethyl]trl-methylammonium salts, N, N-dimethylaminopropyl acrylamide (DMAPA), N, N-dimethylaminopropyl methacrylamide (DMAPMA), acrylamidopropyl trimethyl P0001010 CPL

[0152] 15 ammonium salts (APTAS), methacrylamidopropyl trimethylammonium salts (MAPTAS), quaternized vinylimidazole (QVi), and mixtures thereof.

[0153] The cationic polymer may comprise anionic structural units derived from monomers selected

[0154] 5 from: acrylic acid (AA), methacrylic acid, maleic acid, vinyl sulfonic acid, styrene sulfonic acid, acrylamidopropylmethane sulfonic acid (AMPS) and their salts, and mixtures thereof.

[0155] Some cationic polymers disclosed herein will require stabilisers i.e. materials which will exhibit a yield stress in the ancillary laundry composition of the present invention. Such stabilisers may be selected from: thread like structuring systems for example hydrogenated castor oil or trihydroxystearin e.g. Thixcin ex. Elementis Specialties, crosslinked polyacrylic acid for example Carbopol ex. Lubrizol and gums for example carrageenan.

[0156] Preferably the cationic polymer is selected from; cationic polysaccharides and acrylate polymers.

[0157] 15

[0158] The fabric conditioner compositions described herein may preferably additional ingredients as will be known by the person skilled in the art. A non-limiting list of such ingredients include: solvents, antifoams, insect repellents, shading or hueing dyes, preservatives (e.g. bactericides), anti microbial agents, pH buffering agents, perfume carriers, additional malodor ingredients, dye

[0159] 20 transfer inhibitors, hydrotropes, anti-redeposition agents, soil-release agents, polyelectrolytes, anti-wrinkle agents, oils (e.g. plant based oils and mineral oils), plant extracts, waxes, sugaresters, anti-oxidants, dyes, colorants, sunscreens, anti-corrosion agents, anti-static agents, sequestrants and silicones.

[0160] 25 The fabric conditioner composition is preferably aqueous, preferably comprises water, more preferably at least 60 wt.% water, even more preferably 70 wt.% water. The compositions preferably comprise less than 98 wt.% water, more preferably less than 95 wt.% water.

[0161] The fabric conditioning composition may be used to treat fabrics either in a hand washing or a machine washing process. Preferably the fabric conditioner is used in the rinse stage of the

[0162] 30 washing process.

[0163] Preferably the clothes are treated with a 10 to 100 ml dose of fabric conditioner for a 4 to 7 kg load of clothes. More preferably, 10 to 80 ml for a a 4 to 7 kg load of clothes. P0001010 CPL

[0164] 16

[0165] Preferably, the composition of the present invention is used to clean a hard surface in the kitchen especially that which is cleaned by hand e.g dishes, utensils, cutlery, and crockery. The invention also ensures good delivery of skin health when used to clean implements like sponges, mops and scrubs. In such cases the composition may be used in diluted form with water. The dilution

[0166] 5 with water in such cases is preferably in the range of 1 :1 to 1 :100 and more preferably in a ratio of between 1 :1 to 1 :10.

[0167] The present invention may therefore be delivered as a hand dish wash composition which preferably comprises a surfactant system comprising 1 to 20 wt% anionic surfactant. Other surfactants may be included with total amount of 3 to 30 wt%, preferably 5 to 30 wt% surfactants. Generally, the anionic surfactant included is called the primary surfactant. The anionic surfactant is preferably selected from one or more of an alkyl ether sulphate surfactant, an alkyl sulphate surfactant and an alkyl benzene sulphonate surfactant. The primary anionic surfactant is preferably included in 2 to 20 wt%, preferably 2 to 10 wt% of the composition.

[0168] 15 The anionic surfactant is preferably an alkyl sulphate surfactant. The alkyl sulphate surfactant for inclusion in the composition of the invention preferably has 10 to 18 carbon atoms, more preferably 10 to 12 carbon atoms. The surfactant has a counterion which is an alkali metal such as sodium or potassium; or an ammoniacal counterion such as monoethanolamine, (MEA) diethanolamine (DEA) or triethanolamine (TEA). Preferably it is sodium or potassium, most

[0169] 20 preferably it is sodium. The most preferred surfactant of this class for inclusion in the composition of the invention is sodium lauryl sulphate. The alkyl sulphate surfactant is included in 2 to 5%, preferably 3 to 4% by weight of the composition.

[0170] The anionic surfactant is preferably an alkyl ether sulphate surfactant. The alkyl ether sulphate

[0171] 25 surfactant for inclusion in the composition of the invention preferably has 10 to 18 carbon atoms, more preferably 10 to 12 carbon atoms. The alkyl ether sulphate surfactant preferably has one to ten ethylene oxide or propylene oxide units per molecule, preferably one to three ethylene oxide units per molecule. The surfactant has a counterion which is an alkali metal such as sodium or potassium; or an ammoniacal counterion such as monoethanolamine, (MEA) diethanolamine

[0172] 30 (DEA) or triethanolamine (TEA). Preferably it is sodium or potassium, most preferably it is sodium. The most preferred surfactant of this class for inclusion in the composition is sodium laureth sulphate 1 EO. P0001010 CPL

[0173] 17

[0174] Another class of anionic surfactant that may preferably be included is of the alkylbenzene sulfonates type, particularly linear alkylbenzene sulfonates (LAS) with an alkyl chain length of from 10 to 18 carbon atoms.

[0175] 5 The hand dish wash composition as per the invention preferably also includes a secondary surfactant which may be an amphoteric surfactant. The amphoteric surfactant is selected from one or both of alkyl amidopropyl betaine surfactant and amine oxide surfactant. Preferred alkyl amidopropyl betaine is cocoamido propyl betaine. The amine oxide may be any one of the C8 - C18 alkyl amine n-oxide (which is broadly referred to an amine oxide). The preferred amine oxide is one or both of lauramine oxide or lauryl / myristyl amido propyl amine oxide. The more preferred amine oxide is lauramine oxide.

[0176] Preferably, the composition preferably comprises 1 to 20 wt%, more preferably 1 to 5 wt%, of the amphoteric surfactant.

[0177] It is preferred that the weight ratio of the primary anionic surfactant to the secondary amphoteric

[0178] 15 surfactant is between 1.5:1 to 20:1 , more preferably between 1.5: 1 to 5: 1.

[0179] In certain embodiments, ancillary or top-up compositions may be applied subsequent to a primary wash cycle, either in conjunction with or independent of a fabric conditioning composition. When such ancillary compositions comprise the polysaccharides as per the invention they facilitate

[0180] 20 fragrance deposition which can be modulated by the surfactant system present within the formulation. It has been observed that use of a surfactant system wherein the weight ratio of anionic to nonionic surfactant is at least 1 enhances the fragrance impact.

[0181] Furthermore, the presence of higher amounts of anionic or cationic surfactants as compared to non-ionic surfactants in any composition as per the invention has been found to be advantageous

[0182] 25 for promoting enhanced fragrance deposition. More preferably the weight ratio of the anionic surfactant to the non-ionic surfactant is higher than 1.5:1 , more preferably higher than 2:1 , further more preferably higher than 4:1. It is further more preferred that when non-ionic surfactant is present, it is included in less than 15%, further more preferably less than 9%, even further more preferably less than 3% by weight of the composition. In certain embodiments, non-ionic

[0183] 30 surfactant is absent from the composition. When non-ionic surfactant is included in the composition as per the invention, it is preferred that the weight ratio of the non-ionic surfactant to resistant dextrin is less then 15:1 , more preferably less then 9:1. P0001010 CPL

[0184] 18

[0185] The invention also relates to a method of delivering skin health to a person wearing a laundered fabric wherein the laundry process comprises the steps of (i) contacting the fabric pre-wet with water with a composition of the first aspect; (ii) rinsing the fabric with water; and (iii) drying the rinsed fabric.

[0186] 5

[0187] When the composition is formulated as a laundry detergent composition, the composition may be diluted in water after which the fabric is washed either by hand or in a machine. Thereafter the washed fabric may be rinsed two or three times, squeeze dried and thereafter dried either in a drying machine or left out to dry on a clothesline.

[0188] When formulated as a fabric conditioning composition the composition may be added to the rinse water preferably in the last stage of rinsing and then squeeze dried before drying in a machine or on a clothesline.

[0189] The invention also relates to a method of delivering skin health to the hands of a person

[0190] 15 comprising the steps of hand washing fabric with a laundry detergent composition or a fabric conditioning composition of the invention preferably diluted with water.

[0191] The invention also relates to a method of delivering skin health to the hands of a person comprising the steps of hand washing dishes with a hand dish wash composition of the invention

[0192] 20 preferably diluted with water.

[0193] The invention will now be illustrated with the help of the following examples.

[0194] Examples

[0195] 25

[0196] Example 1 : Upregulation of Kallikrein 5 through use of pectin

[0197] Pectin was used to study the effect on the Kallikrein 5 gene. Pectin for use in the present invention was sourced from CP Kelco, UK.

[0198] The method used was as follows:

[0199] Pectin (at 0.025%) was added onto differentiated HaCaT (Human Keratinocyte cell line) cells and incubated for 24 hours. Post incubation, RNA was harvested from the cells for gene expression analysis via Real Time quantitative Polymerase Chain reaction.

[0200] 35 The result is summarised in Table -1 : P0001010 CPL

[0201] 19

[0202] Table -1

[0203] The data in Table -1 indicates that pectin is responsible for several fold increase in upregulation

[0204] 5 of the kallikrein 5 gene in comparison to the control.

[0205] Example 2: Upregulation of Loricrin through use of resistant dextrin

[0206] Resistant dextrin (at 0.01%) was used to study the effect on Loricrin gene. Resistant dextrin for use in the present invention was Fibersol 2 from ADM Bio Science & Technology (Tianjin) Co. Ltd., Tianjin, China.

[0207] The method used was as follows:

[0208] Resistant dextrin along with skin swab filtrate was added onto differentiated HaCaT (Human

[0209] 15 Keratinocyte cell line) cells and incubated for 24 hours. Post incubation, RNA was harvested from the cells for gene expression analysis via Real Time guantitative Polymerase Chain reaction.

[0210] The result is summarised in Table -2:

[0211] 20

[0212] Table -2

[0213] The data in Table -2 indicates that resistant dextrin is responsible for several fold increase in upregulation of loricrin gene in comparison to the control.

[0214] 25

[0215] Example 3, 4: Upregulation of Involucrin, Loricrin and Filaggrin through use of a combination of pectin and resistant dextrin P0001010 CPL

[0216] 20

[0217] Pectin in combination with resistant dextrin was used to study the effect on Involucrin, Loricrin and Filaggrin gene. The amounts used were as follows:

[0218] Example - 3: 0.01% Pectin and 0.02% resistant dextrin on the cells

[0219] Example - 4: 0.02% Pectin and 0.01% resistant dextrin on the cells

[0220] 5 The method used was as follows:

[0221] Pectin and resistant dextrin in different ratios was added onto differentiated HaCaT (Human Keratinocyte cell line) cells and incubated for 24 hours. Post incubation, RNA was harvested from the cells for gene expression analysis via Real Time quantitative Polymerase Chain reaction.

[0222] The result is summarised in Table -3:

[0223] Table -3

[0224] 15 The data in Table -3 indicates that the combination of pectin and resistant dextrin is responsible for several fold increase in upregulation of involucrin, loricrin and filaggrin gene in comparison to the control.

[0225] Example A, 5: Effect of inclusion of the actives as per the invention in a fabric conditioning

[0226] 20 composition on upregulation of Filaggrin.

[0227] A fabric conditioning composition as shown in Table - 4 below was used along with a composition that also included pectin and resistant dextrin.

[0228] 25

[0229] Table - 4: P0001010 CPL

[0230] 21

[0231] The upregulation of Filaggrin was measured using the following procedure.

[0232] Skin HaCaT cell culture experiments: Swatches washed in the fabric conditioning composition of Table - 4 above (Example - A) and with a composition additionally having 0.4 wt% fibersol and

[0233] 5 0.1 wt% pectin (Example - 5) were placed on a monolayer of skin cells for 24 hours. Post exposure, cells were harvested for RNA isolation and qPCR to assess the change in gene expression levels of skin barrier function genes such as Filaggrin. The data is summarized in Table - 5 below.

[0234] 10 Table - 5:

[0235] The data in the Table - 5 above indicates fabric washed with a fabric conditioning composition as per the invention (Example -5) was found to be vastly superior in upregulating genes beneficial to skin health.

[0236] Example B, 6: Effect of inclusion of the actives as per the invention in a powder fabric cleaning composition on reduction in hydration and increase in TEWL before and after immersion in a wash liquor.

[0237] Powder detergent composition as shown in Table 6 below was taken and the above parameters

[0238] 20 were measured using the procedure given below:

[0239] Table - 6 P0001010 CPL

[0240] 22

[0241] Volunteers had one hand immersed into in a 3 gram per liter (gpl) solution of composition of Example B while the other hand was immersed in a 3 gpl solution of composition of Example 6. The composition of Examples B and 6 were randomised amongst 24 volunteers. The hands were

[0242] 5 dipped in to the wash liquor for 10 minutes on day 1 , 2 and 3. Hydration and TEWL (trans epidermal water loss) assessments were done on day 1 , 2 and 3 before and after hand dipping.

[0243] Hydration was measured using a Corneometer, which works based on the principle of electrical conductance. Output is presented in the unit of micro-Siemens (pS). Electrical conductance of

[0244] 10 the stratum corneum is directly proportional to the skin’s hydration level. Corneometry can be used to demonstrate the efficacy of products applied to the skin which are intended to improve hydration

[0245] Skin TEWL measurement was done using a Tewameter probe which measures the density gradient of the water evaporation from the skin indirectly by two pairs of sensors (temperature and relative humidity).

[0246] The difference before and after hand immersion was plotted as the percentage change in hydration and TEWL. The data is presented in Table -7 as an average % change for 24

[0247] 20 volunteers.

[0248] Table -7: P0001010 CPL

[0249] 23

[0250] The data in the Table - 7 above indicates that composition as per the invention (Example -6) consistently delivers lower decrease in hydration over the three days as compared to a standard detergent powder (Example - B). This benefit is further corroborated by TEWL measurements 5 where the composition as per the invention (Example - 6) deliver lower amount of water loss as compared to Example - B.

Claims

1. P0001010 CPL24Claims1. A home care cleaning composition for delivering benefits to skin comprising(i) 0.001 to 10 wt% pectin;(ii) 0.001 to 10 wt% resistant dextrin; and(iii) a surface treatment active selected from one or both of a surfactant or a fabric softening active.

2. The composition as claimed in any one of the preceding claims wherein the pectin is derived from one or more of a fruit selected from pear, apple, guava, plum, gooseberry, orange and any other citrus fruit, preferably citrus fruit.

3. The composition as claimed in any one of the preceding claims which is a laundry detergent composition comprising 1 to 80 wt% surfactant.

4. The composition as claimed in claim 3 comprising 5 to 60% anionic surfactant.

5. The laundry detergent composition as claimed in claim 3 and 4 comprising 1 to 20% non-ionic surfactant.

6. The composition as claimed in claims 1 or 2 which is a fabric conditioning composition additionally comprising 1 to 50% of a fabric softening active.

7. The fabric conditioning composition as claimed in claim 6 wherein the fabric softening active is a quaternary ammonium compound.

8. The fabric conditioning composition as claimed in claim 7 comprising 0.1 to 10 wt% of a cationic polymer.

9. The composition as claimed in claims 1 or 2 which is a hand dish wash composition comprising 1 to 20 wt% anionic surfactant.

10. A method of delivering skin health to a person wearing a laundered fabric wherein the laundry process comprises the steps ofP0001010 CPL25(i)contacting the fabric pre-wet with water with a composition as claimed in any one of the preceding claims 1 to 8;(ii) rinsing the fabric with water; and(iii) drying the rinsed fabric.

11. A method of delivering skin health to the hands of a person comprising the steps of hand washing fabric with a laundry detergent composition as claimed in claims 5 or 6 or a fabric conditioning composition as claimed in claims 7 or 8, preferably diluted with water.

12. A method of delivering skin health to the hands of a person comprising the steps of hand washing dishes with a composition as claimed in claim 9 preferably diluted with water.

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