Ligation structure

Abstract

This ligation structure comprises: an adhesive for ligating a blood vessel; and a clip (10) on which the adhesive is disposed, wherein the clip (10) comprises a biodegradable material. The adhesive comprises a hydrogel and maintains a ligated state of the blood vessel even after a degradation time, which is the time required for the clip (10) to biodegrade in a human body. The clip (10) comprises: a first binding portion on which the adhesive is disposed; a second binding portion on which the adhesive is disposed; and a connecting portion connecting the first binding portion and the second binding portion. When the blood vessel is in a ligated state by the adhesive disposed on the clip (10), the adhesive on the first binding portion and the adhesive on the second binding portion face each other.

Description

ligation structure

[0001] The present invention relates to a ligation structure.

[0002] This study is related to the Development of Scaffolds for Vascular Expansion Containing Stem Cell Nanovesicles (Project Number: 1415187767, Project Number: 20023041, Research Period: 2023.04.01 ~ 2026.12.31) of the Excellent Corporate Research Institute Promotion Project (ATC+) conducted by Daughter Co., Ltd. with the support of the Korea Institute of Technology Evaluation and Planning (KITEP) and the Ministry of Trade, Industry and Energy (Government), and the Development of Implantable Biodegradable Metal / Hybrid Materials for the Treatment of Vascular Diseases (Project Number: 1711192182, Project Number: 2022M3H4A1A04073271, Research Period: 2022.04.01 ~ 2024.12.31) of the Nanomaterial Technology Development Research Project conducted by the Korea Institute of Science and Technology (KIST) with the support of the National Research Foundation of Korea (Government) and the Ministry of Science and ICT (Government).

[0003] To prevent excessive bleeding and infection during surgical procedures, doctors tie off tubular tissues, such as blood vessels or lymphatic vessels. They also tie off connected blood vessels before removing tumors or organs. To do this, doctors can use sutures to close the surgical site around the blood vessel or clips.

[0004] However, sutures using sutures have limitations: they require sufficient surgical space, require long surgical times, and have the risk of thread unraveling. Furthermore, because sutures are so thin, they can slip and fail to provide a secure hold.

[0005] Metal clips or non-degradable polymer clips are used for vascular ligation. Metal clips typically have a compact, U-shaped design and are made of titanium, tantalum, and stainless steel. However, these metal clips can interfere with imaging devices such as CT and MRI, and are prone to loosening. Furthermore, while metal clips adhere well to blood vessels horizontally, they tend to dislodge vertically.

[0006] To address the issues with metal clips, non-degradable polymer clips made of materials like polyacetal have been proposed. However, non-degradable polymer clips can persist in the body after surgery, potentially causing complications due to inflammation. Furthermore, non-degradable polymer clips are less likely to be removed vertically from blood vessels, but more likely to be removed horizontally. Furthermore, non-degradable polymer clips have high rigidity and low resilience, which can easily lead to breakage during ligation or weaken the ligation effect.

[0007] The embodiments of the present invention were invented against the background described above, and are intended to provide a ligation structure that effectively ligates blood vessels and then is biodegraded.

[0008] A ligation structure according to one aspect of the present invention comprises: an adhesive for ligating a blood vessel; and a clip on which the adhesive is disposed, wherein the clip comprises a biodegradable material.

[0009] Additionally, the adhesive comprises a hydrogel and can maintain the blood vessel ligation even after the degradation time, which is the time required for the clip to biodegrade in the human body.

[0010] In addition, the clip includes a first binding portion on which the adhesive is disposed; a second binding portion on which the adhesive is disposed; and a connecting portion connecting the first binding portion and the second binding portion, and when the blood vessel is in a ligated state by the adhesive disposed in the clip, the adhesive of the first binding portion and the adhesive of the second binding portion may face each other.

[0011] Additionally, the clip may include an elastic material.

[0012] In addition, a groove is formed at the end of the first binding portion, and an insertion portion inserted into the inside of the groove is formed at the second binding portion; and a protrusion that is caught at the end of the groove is formed, and when the protrusion is caught at the end of the groove, at least a portion of the adhesive arranged at the first binding portion and at least a portion of the adhesive arranged at the second binding portion come into contact, thereby ligating a blood vessel.

[0013] In addition, a first convex portion is formed on the inner surface of the first binding portion where the adhesive is placed, a second convex portion is formed on the inner surface of the second binding portion where the adhesive is placed, and the first convex portion and the second convex portion may not face each other when in the binding state.

[0014] Additionally, the first convex portion and the second convex portion may be provided in multiple pieces.

[0015] Additionally, the inner surface of the first binding portion and the inner surface of the second binding portion may face each other in a zigzag shape.

[0016] According to embodiments of the present invention, the adhesive can permanently ligate the blood vessel.

[0017] Additionally, according to embodiments of the present invention, ligation can be performed without interfering with the accuracy of follow-up examinations such as MRI or CT.

[0018] FIG. 1 is a perspective view of a ligation structure according to a first embodiment of the present invention.

[0019] Figure 2 is a front view of Figure 1.

[0020] Figure 3 is a drawing of a ligation structure that ligates a blood vessel.

[0021] Figures 4 to 7 show clips that biodegrade over time.

[0022] Figure 8 is a drawing showing the adhesive strength of the adhesive.

[0023] Figure 9 is a perspective view of a ligation structure according to a second embodiment of the present invention.

[0024] Figure 10 is a view of Figure 9 with the adhesive omitted.

[0025] Figure 11 is a front view of Figure 9.

[0026] Fig. 12 is a perspective view of a ligation structure according to a third embodiment of the present invention.

[0027] Figure 13 is a front view of Figure 12.

[0028] Hereinafter, specific embodiments for implementing the technical idea of ​​the present invention will be described in detail with reference to the drawings.

[0029] In addition, when explaining the present invention, if it is determined that a detailed description of a related known configuration or function may obscure the gist of the present invention, the detailed description is omitted.

[0030] Additionally, when it is said that a component is 'connected' or 'in contact with' another component, it should be understood that it may be directly connected or in contact with that other component, but there may also be other components in between.

[0031] The terminology used herein is intended solely to describe specific embodiments and is not intended to limit the invention. Singular expressions include plural expressions unless the context clearly dictates otherwise.

[0032] Additionally, please note that the terms "upper side," "lower side," and "side" in this specification are based on the illustrations in the drawings and may be expressed differently if the orientation of the subject changes. For the same reason, some components in the attached drawings are exaggerated, omitted, or schematically depicted, and the sizes of each component do not fully reflect the actual size.

[0033] Additionally, terms that include ordinal numbers, such as "first," "second," etc., may be used to describe various components, but these components are not limited by such terms. These terms are used solely to distinguish one component from another.

[0034] The term "comprising" as used in the specification means specifying a particular characteristic, region, integer, step, operation, element and / or component, but does not exclude the presence or addition of other particular characteristics, regions, integers, steps, operations, elements, components and / or groups.

[0035] Hereinafter, a ligation structure (1) according to one embodiment of the present invention will be described with reference to FIGS. 1 and 2. The ligation structure (1) can block blood flow by ligating a blood vessel. The ligation structure (1) may include a clip (10) and an adhesive (20).

[0036] An adhesive (20) may be disposed on the clip (10). The clip (10) may include a biodegradable material. For example, the clip (10) may include polycaprolactone (PCL), poly-L-lactide (PLLA), polyglycolic acid (PGA), poly(lactic-co-glycolic acid) (PLGA), polybutylene succinate (PBS), and poly(3-hydroxybutyrate) (PHB). When the clip (10) is biodegraded, the shape of the clip (10) may not exist in the body. When the clip (10) is biodegraded, the adhesive (20) may remain in the body and ligate a blood vessel. The clip (10) may include an elastic material. The clip (10) may include a first fastening portion (100), a second fastening portion (200), and a connecting portion (300).

[0037] An adhesive (20) may be placed inside the first binding portion (100). A groove (101) may be formed at an end of the first binding portion (100). The first binding portion (100) may face the second binding portion (200) when in a binding state described later. The surface of the first binding portion (100) on which the adhesive (20) is placed may have a shape that extends long in one direction. One end of the first binding portion (100) may be connected to a connecting portion (300), and a groove (101) may be formed at the other end of the first binding portion (100).

[0038] The groove (101) can provide a space into which the insertion portion (201) to be described later is inserted. The groove (101) can be formed at an end of the first fastening portion (100). The width of the first fastening portion (100) of the groove (101) in the extension direction can be greater than the width of the second fastening portion (200) of the insertion portion (201) to be described later in the extension direction. For example, the width of the first fastening portion (100) of the groove (101) in the extension direction can be greater than 1.2 times and less than 2 times the width of the second fastening portion (200) of the insertion portion (201) in the extension direction. When in a ligature state, a protrusion (202) can be caught at the end of the groove (101).

[0039] An adhesive (20) may be placed inside the second binding portion (200). The inner surface of the second binding portion (200) may face the inner surface of the first binding portion (100) when in a ligature. When in a ligature, the adhesive (20) inside the second binding portion (200) and the adhesive (20) inside the first binding portion (100) may be in contact. An insertion portion (201) and a protrusion portion (202) may be formed in the second binding portion (200). One end of the second binding portion (200) may be connected to the connection portion (300), and the insertion portion (201) and the protrusion portion (202) may be formed in the other end of the second binding portion (200).

[0040] The insertion portion (201) can be inserted into the groove portion (101) when in a ligated state. The width of the second fastening portion (200) of the insertion portion (201) in the extension direction can be smaller than the width of the first fastening portion (100) of the groove portion (101) in the extension direction. When in a ligated state, the insertion portion (201) can be placed on the outside of the blood vessel.

[0041] The protrusion (202) can be caught on the end of the groove (101) when in a ligatured state. When the protrusion (202) is caught on the end of the groove (101), at least a portion of the adhesive (20) arranged on the first binding portion (100) and at least a portion of the adhesive (20) arranged on the second binding portion (200) come into contact, thereby ligating the blood vessel. The protrusion (202) can include an elastic material. When the protrusion (202) includes an elastic material, the protrusion (202) can be caught on the end of the groove (101). The width of the protrusion (202) in the extension direction of the second binding portion (200) of the insertion portion (201) can be smaller than the width of the second binding portion (200) in the extension direction. For example, the width of the second fastening portion (200) of the protrusion (202) in the extension direction may be greater than 0.5 times and less than 0.9 times the width of the second fastening portion (200) of the insertion portion (201) in the extension direction. The state in which the protrusion (202) is caught on the end of the groove (101) may be referred to as a ligation state.

[0042] The connecting portion (300) can connect the first binding portion (100) and the second binding portion (200). The connecting portion (300) can be connected to one end of the first binding portion (100) and one end of the second binding portion (200).

[0043] The adhesive (20) can ligate a blood vessel. The adhesive (20) may include a hydrogel and may have properties that allow it to maintain adhesion even in a humid environment. The adhesive (20) can maintain the blood vessel in a ligate state even after the degradation time, which is the time required for the clip (10) to be completely biodegraded, has elapsed. After the degradation time has elapsed, the clip (10) loses its shape, and only the adhesive (20) can ligate the blood vessel. The adhesive (20) can permanently ligate the blood vessel. When the adhesive (20) ligates the blood vessel, blood flow in the blood vessel may be inhibited.

[0044] When in a ligature state, a blood vessel can be ligated by an adhesive (20) placed on a clip (10). When in a ligature state, the blood vessel can be placed between a first binding portion (100) and a second binding portion (200). When in a ligature state, the insertion portion (201) can be inserted into the inside of the groove portion (101) and the protrusion portion (202) can be caught on the end of the groove portion (101). When in a ligature state, the flow of blood can be suppressed, thereby preventing blood from flowing to unnecessary places. A state other than a ligature state can be called a release state. In a release state, the first binding portion (100) and the second binding portion (200) may not face each other.

[0045] Hereinafter, the operation and effect of the ligation structure (1) having the configuration described above will be described with reference to FIGS. 3 to 8.

[0046] The adhesive (20) of the ligation structure (1) according to the first embodiment of the present invention has the effect of permanently ligating blood vessels. Even if the clip (10) is biodegraded, the adhesive (20) does not decompose and can ligate blood vessels in the body.

[0047] In addition, the adhesive (20) of the ligation structure (1) according to the first embodiment of the present invention has the property of maintaining adhesion to the blood vessel and ligation even when the clip (10) is biodegraded, and maintaining adhesion even in a wet environment, so that the risk of blood vessels, which are slippery organs, being reopened is low, and there is an effect of being able to ligate without interfering with the accuracy of follow-up examinations such as MRI or CT.

[0048] Meanwhile, in addition to these configurations, a ligation structure (1) according to a second embodiment of the present invention may be provided. Hereinafter, the second embodiment of the present invention will be described with reference to FIGS. 9 to 11. In describing the second embodiment, differences compared to the above-described embodiment will be primarily described, and the same description will refer to the above-described embodiment.

[0049] Referring to FIGS. 9 to 11, a first convex portion (102) may be formed on the first fastening portion (100). The first convex portion (102) may be formed on the inner surface of the first fastening portion (100) where the adhesive (20) is disposed. The first convex portion (102) may be provided in single or multiple pieces. The height of the first convex portion (102) in a direction perpendicular to the extension direction may be greater than 1 / 5 and less than 4 / 5 of the height of the first fastening portion (100) in a direction perpendicular to the extension direction. For example, the height of the first convex portion (102) in a direction perpendicular to the extension direction may be 1 / 3 of the height of the first fastening portion (100) in a direction perpendicular to the extension direction.

[0050] The second convex portion (203) may be formed on the second fastening portion (200). The second convex portion (203) may be formed on the inner surface of the second fastening portion (200) where the adhesive (20) is disposed. The second convex portion (203) may be provided in single or multiple pieces. The second convex portion (203) may not face the first convex portion (102) when in a fastened state. The height of the second convex portion (203) in a direction perpendicular to the extension direction may be greater than 1 / 5 and less than 4 / 5 of the height of the second fastening portion (200) in a direction perpendicular to the extension direction. For example, the height of the second convex portion (203) in a direction perpendicular to the extension direction may be 1 / 3 of the height of the second fastening portion (200) in a direction perpendicular to the extension direction.

[0051] Below, the operation and effect of the ligation structure (1) having the configuration described above will be described.

[0052] The adhesive (20) disposed on the inner surface of the first binding portion (100) and the adhesive (20) disposed on the inner surface of the second binding portion (200) can be more closely connected and ligated by the first convex portion (102) and the second convex portion (203). When the adhesive (20) disposed on the inner surface of the first binding portion (100) and the adhesive (20) disposed on the inner surface of the second binding portion (200) are more closely connected and ligated, the area of ​​the blood vessel that is not ligated can be reduced.

[0053] Meanwhile, in addition to these configurations, a ligation structure (1) according to a third embodiment of the present invention may be provided. Hereinafter, the third embodiment of the present invention will be described with reference to FIGS. 12 and 13. In describing the third embodiment, differences compared to the above-described embodiment will be primarily described, and the same description will refer to the above-described embodiment.

[0054] Referring to FIGS. 12 and 13, the inner surface of the first fastening portion (100) and the inner surface of the second fastening portion (200) may face each other in a zigzag shape. The inner surface of the first fastening portion (100) and the inner surface of the second fastening portion (200) may also have a zigzag shape. An adhesive (20) may be arranged in a zigzag shape on the inner surface of the first fastening portion (100) and the inner surface of the second fastening portion (200).

[0055] Although the embodiments of the present invention have been described as specific embodiments, these are merely examples, and the present invention is not limited thereto, but should be construed to have the broadest scope in accordance with the technical concepts disclosed in this specification. Those skilled in the art may combine / substitute the disclosed embodiments to implement patterns of shapes not specified, but this also does not depart from the scope of the present invention. In addition, those skilled in the art may easily modify or alter the disclosed embodiments based on this specification, and it is clear that such modifications or alterations also fall within the scope of the present invention.

Claims

1. Adhesive for ligating blood vessels; and Includes a clip on which the adhesive is placed, The above clip contains a biodegradable material, Ligation structure.

2. In paragraph 1, The adhesive comprises a hydrogel and maintains the blood vessel ligation even after the degradation time, which is the time required for the clip to biodegrade in the human body. Ligation structure.

3. In paragraph 1, The above clip is, A first bonding portion on which the adhesive is placed; a second bonding portion on which the adhesive is placed; and Including a connecting portion connecting the first binding portion and the second binding portion, When the blood vessel is ligated by the adhesive placed on the clip, the adhesive of the first binding part and the adhesive of the second binding part face each other. Ligation structure.

4. In paragraph 3, The above clip comprises an elastic material, Ligation structure.

5. In paragraph 4, A groove is formed at the end of the first binding portion, In the above second binding part, an insertion portion inserted into the inside of the above home portion; and A protrusion that is caught on the end of the above home portion is formed, When the protrusion is caught on the end of the groove, at least a portion of the adhesive disposed on the first fastening portion and at least a portion of the adhesive disposed on the second fastening portion come into contact and ligate the blood vessel. Ligation structure.

6. In paragraph 5, A first convex portion is formed on the inner surface of the first bonding portion where the adhesive is placed, A second convex portion is formed on the inner surface of the second bonding portion where the adhesive is placed, The first convex portion and the second convex portion do not face each other when in the ligation state. Ligation structure.

7. In paragraph 6, The first convex portion and the second convex portion may be provided in multiple pieces. Ligation structure.

8. In paragraph 3, The inner surface of the first binding part and the inner surface of the second binding part are opposite each other in a zigzag shape. Ligation structure.

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