Lyophilized material transfer mechanism, dual-chamber pre-filled syringe production line and production method, control device and storage medium

Abstract

A lyophilized material transfer mechanism, a dual-chamber pre-filled syringe production line and production method, a control device, and a storage medium. The lyophilized material transfer mechanism (10) is provided with a first feeding conveying assembly (100) for feeding a medicinal container, a second feeding conveying assembly (200) for feeding a lyophilized material, and a pick-and-place assembly (300) for transferring the lyophilized material supplied by the second feeding conveying assembly (200) into the medicinal container supplied by the first feeding conveying assembly (100). The second feeding conveying assembly (200) comprises a first screw (230) and a second screw (240) which are coaxially arranged. The feeding state of the lyophilized material can be adjusted by means of different rotation frequencies of the first screw (230) and the second screw (240), such that the feeding of the lyophilized material can be matched with the feeding of the medicinal container, thereby improving the pre-filling and production effects of the dual-chamber pre-filled syringe.

Description

Freeze-dried material transfer mechanism, double-cavity pre-filled syringe production line, production method, control device and storage medium TECHNICAL FIELD

[0001] The present application relates to the technical field of medical equipment, in particular to a freeze-dried material transfer mechanism, a double-cavity pre-filled syringe production line, a production method, a control device and a storage medium. BACKGROUND

[0002] A syringe is a common medical device, which is mainly used to extract or inject liquid through a needle.

[0003] A special syringe is a double-cavity pre-filled syringe, which is widely used in occasions where multiple drugs or liquids need to be mixed. The syringe is provided with two independent cavities, different liquids or drugs are stored in the two cavities respectively, and a communication passage for communicating the two cavities is further provided on the barrel of the syringe. When in use, the user changes the position of the rubber plug in the syringe by pressing the plunger of the syringe, and when the rubber plug moves to the position of the communication passage, the two cavities are communicated through the communication passage, so that the components in the two cavities can be mixed.

[0004] However, the current production equipment cannot well realize the pre-filling and production of the double-cavity pre-filled syringe.

[0005] SUMMARY

[0006] The present application provides a freeze-dried material transfer mechanism, a double-cavity pre-filled syringe production line, a production method, a control device and a storage medium to improve the pre-filling and production of the double-cavity pre-filled syringe.

[0007] The first aspect of the present application provides a freeze-dried material transfer mechanism, which comprises,

[0008] A first feeding conveying assembly for feeding a medical container;

[0009] A second feeding conveying assembly for feeding a freeze-dried material, the second feeding conveying assembly comprising a first driving mechanism, a second driving mechanism, and a first screw and a second screw coaxially arranged, the first driving mechanism being drivingly connected to the first screw, the second driving mechanism being drivingly connected to the second screw, the first screw and the second screw being adjacently arranged along the conveying direction of the second feeding conveying assembly; and a taking and placing assembly for transferring the freeze-dried material supplied by the second feeding conveying assembly into the medical container supplied by the first feeding conveying assembly.

[0010] In some embodiments, the second screw is provided with a first feeding position and a second feeding position, the first feeding position being located downstream of the second feeding position, and the second screw can adjust the feeding state by switching the rotation frequency.

[0011] In some embodiments, the second screw rod can be switched among four feeding states, wherein in the first feeding state, the first feeding position and the second feeding position both have the freeze-dried material; in the second feeding state, the first feeding position has no freeze-dried material and the second feeding position has the freeze-dried material; in the third feeding state, the first feeding position has the freeze-dried material and the second feeding position has no freeze-dried material; and in the fourth feeding state, the first feeding position and the second feeding position both have no freeze-dried material.

[0012] In some embodiments, the freeze-dried material picking mechanism further comprises a detection mechanism for detecting the feeding pharmaceutical containers and obtaining a detection result; and the second feeding conveying assembly adjusts the feeding state of the second screw rod according to the detection result.

[0013] In some embodiments, the picking and placing assembly comprises a driving mechanism and at least one set of picking and placing units, and the driving mechanism is used to drive the picking and placing units to move between the first feeding conveying assembly and the second feeding conveying assembly, so as to feed the freeze-dried material into the pharmaceutical containers.

[0014] In some embodiments, the driving member can drive the picking and placing units to switch between the first station and the third station; in the first station, at least one set of the picking and placing units correspond to the first feeding position and the second feeding position of the second screw rod, so as to obtain the freeze-dried material; and in the third station, at least one set of the picking and placing units correspond to the position of the first feeding conveying assembly, so as to place the freeze-dried material into the pharmaceutical containers.

[0015] In some embodiments, the driving member can further drive the picking and placing units to the second station, and the second station is provided with a second detection mechanism for detecting the freeze-dried material.

[0016] In some embodiments, the driving member can further drive the picking and placing units to the fourth station, and the fourth station is a cleaning station.

[0017] In some embodiments, each set of picking and placing units comprises two picking and placing members, and the arrangement positions of the two picking and placing members correspond to the arrangement positions of the first feeding position and the second feeding position.

[0018] In some embodiments, the driving member comprises a rotary driving member, which is drivingly connected to the picking and placing units, so as to drive the picking and placing units to rotate and switch among the first station, the second station, the third station and the fourth station; and the first station, the second station, the third station and the fourth station are arranged along the circumference in sequence and uniformly.

[0019] In some embodiments, the pick-and-place unit comprises at least one pick-and-place member, which is a vacuum suction member, and a collection container is arranged at the fourth station for collecting the ejected material when the pick-and-place member ejects air outward.

[0020] In some embodiments, the pick-and-place assembly further comprises a central shaft, a vacuum source and a support, the central shaft is connected to the support through the gas slide ring, the vacuum source is in gas communication with the gas slide ring, and the gas slide ring is in gas communication with each of the vacuum suction members to provide positive pressure or negative pressure for each of the vacuum suction members.

[0021] In some embodiments, the pick-and-place assembly comprises four groups of pick-and-place units, which are arranged uniformly along the circumference.

[0022] In some embodiments, the driving member further comprises a lifting driving member connected to the pick-and-place unit for driving the pick-and-place unit to lift.

[0023] In some embodiments, the lyophilized material picking mechanism further comprises a connecting member, the rotating driving member is arranged on the connecting member, the pick-and-place assembly has a central shaft, the pick-and-place unit is connected to the central shaft, the central shaft is rotatably connected to the connecting member and in transmission connection with the rotating driving member, and the lifting driving member is connected to the connecting member to drive the connecting member, the rotating driving member and the pick-and-place unit to lift.

[0024] In some embodiments, the lyophilized material picking mechanism further comprises a guide post, a guide sleeve and a fixing frame, one of the guide post and the guide sleeve is connected to the fixing frame, and the other is connected to the connecting member, and the guide post is fitted in the guide sleeve, and the guide post extends along the lifting direction of the connecting member.

[0025] The second aspect of the present application provides a double-cavity pre-filled syringe production line, which comprises a filling unit, the filling unit comprising:

[0026] a first sealing mechanism for arranging a first sealing body in the medicinal container;

[0027] a filling mechanism arranged downstream of the first sealing mechanism, the filling mechanism being used for filling a liquid in the medicinal container;

[0028] a second sealing mechanism arranged downstream of the filling mechanism, the second sealing mechanism being used for arranging a second sealing body in the medicinal container, and a liquid chamber for accommodating the liquid is formed between the first sealing body and the second sealing body;

[0029] The freeze-dried material transfer mechanism provided in any of the foregoing embodiments is disposed downstream of the second sealing mechanism for adding freeze-dried material into the pharmaceutical container;

[0030] A third sealing mechanism is disposed downstream of the freeze-dried material transfer mechanism for providing a third sealing body in the pharmaceutical container for sealing the freeze-dried material.

[0031] In some embodiments, a first flipping mechanism is provided downstream of the second sealing mechanism and upstream of the freeze-dried material removal mechanism. The first flipping mechanism is used to flip the pharmaceutical container. A chamber for accommodating the freeze-dried material is formed between the first sealing body and the third sealing body.

[0032] In some embodiments, the dual-chamber pre-filled syringe production line further includes a third detection mechanism located downstream of the freeze-dried material transfer mechanism and upstream of the third sealing mechanism, for detecting the communication status between the liquid chamber for containing liquid and the chamber for containing freeze-dried material within the pharmaceutical container.

[0033] In some embodiments, the dual-chamber pre-filled syringe production line further includes a laminar flow hood, in which the first sealing mechanism, the filling mechanism, the second sealing mechanism, and the freeze-dried material removal mechanism are disposed and are in a Class A laminar flow environment.

[0034] In some embodiments, the dual-chamber pre-filled syringe production line further includes:

[0035] A pharmaceutical container supply unit is disposed upstream of the filling unit for supplying pharmaceutical containers to the filling unit;

[0036] A freeze-dried material supply unit is located upstream of the filling unit for supplying freeze-dried material to the filling unit; and a discharge unit is located downstream of the filling unit for discharging material from a pharmaceutical container pre-filled with liquid components and freeze-dried material after assembling it into a syringe.

[0037] A third aspect of this application provides a method for manufacturing a dual-chamber pre-filled syringe, comprising the following steps:

[0038] The pharmaceutical containers are fed through the first feeding and conveying assembly;

[0039] The freeze-dried material is fed through the second feeding and conveying assembly;

[0040] The freeze-dried material supplied by the second feeding and conveying component is transferred to the pharmaceutical container supplied by the first feeding and conveying component by the pick-and-place component;

[0041] The second feeding conveying assembly has four feeding states. In a first feeding state, the first feeding position and the second feeding position of the second feeding conveying assembly both have the freeze-dried material; in a second feeding state, the first feeding position has no freeze-dried material, and the second feeding position has the freeze-dried material; in a third feeding state, the first feeding position has the freeze-dried material, and the second feeding position has no freeze-dried material; and in a fourth feeding state, the first feeding position and the second feeding position both have no freeze-dried material.

[0042] In some embodiments, the method further comprises the steps of: detecting the fed pharmaceutical container by a detection mechanism and obtaining a detection result; and switching the feeding state of the second feeding conveying assembly according to the detection result.

[0043] In some embodiments, the step of moving the freeze-dried material supplied by the second feeding conveying assembly into the pharmaceutical container supplied by the first feeding conveying assembly by the taking-and-placing assembly comprises the following steps:

[0044] In the first station, the freeze-dried material supplied by the second feeding conveying assembly is taken by the taking-and-placing assembly;

[0045] The taking-and-placing assembly is rotated to a third station, and the freeze-dried material is placed into the pharmaceutical container.

[0046] In some embodiments, before the step of rotating the taking-and-placing assembly to the third station and placing the freeze-dried material into the pharmaceutical container, the taking-and-placing assembly is rotated to a second station, and the freeze-dried material is detected by a second detection mechanism.

[0047] In some embodiments, the taking-and-placing assembly moves the freeze-dried material by vacuum adsorption. After the step of rotating the taking-and-placing assembly to the third station and placing the freeze-dried material into the pharmaceutical container, the taking-and-placing assembly is rotated to a fourth station, and air is sprayed out at the fourth station to clean the air path of the taking-and-placing assembly.

[0048] In some embodiments, before the step of feeding the pharmaceutical container by the first feeding conveying assembly, the pharmaceutical container is filled with a liquid, and a liquid chamber for accommodating the liquid is formed.

[0049] In some embodiments, before the step of feeding the pharmaceutical containers by the first feeding conveying assembly, the pharmaceutical containers are fed by a pharmaceutical container feeding unit; before the step of feeding the freeze-dried materials by the second feeding conveying assembly, the freeze-dried materials are fed by a freeze-dried material feeding unit; after the step of moving the freeze-dried materials fed by the second feeding conveying assembly into the pharmaceutical containers fed by the first feeding conveying assembly by the taking and placing assembly, the assembled syringes pre-filled with the liquid components and the freeze-dried materials are discharged by a discharging unit.

[0050] The fourth aspect of the present application provides a control device of a double-chamber pre-filled syringe production line, which comprises,

[0051] The freeze-dried material moving mechanism provided by any of the foregoing embodiments;

[0052] The detection mechanism is configured to detect the fed pharmaceutical containers and obtain a detection result;

[0053] The controller is in signal connection with the freeze-dried material moving mechanism and the detection mechanism, and adjusts the feeding state of the second screw rod of the freeze-dried material moving mechanism according to the detection result.

[0054] The fifth aspect of the present application provides a non-volatile computer readable storage medium, which stores a computer program, and the computer program is executed by a processor to implement the steps in the production method of the double-chamber pre-filled syringe provided by any of the foregoing embodiments.

[0055] The present application has the following beneficial effects: the present application provides a freeze-dried material moving mechanism, a double-chamber pre-filled syringe production line, a production method, a control device and a storage medium, the freeze-dried material moving mechanism is provided with a first feeding conveying assembly for feeding pharmaceutical containers, a second feeding conveying assembly for feeding freeze-dried materials, and a taking and placing assembly for moving the freeze-dried materials fed by the second feeding conveying assembly into the pharmaceutical containers fed by the first feeding conveying assembly, wherein the second feeding conveying assembly comprises a first screw rod and a second screw rod coaxially arranged, and the feeding state of the freeze-dried materials can be adjusted by different rotation frequencies of the first screw rod and the second screw rod. Thus, the feeding of the freeze-dried materials can be matched with the feeding of the pharmaceutical containers, thereby improving the pre-filling and production effect of the double-chamber pre-filled syringe. BRIEF DESCRIPTION OF DRAWINGS

[0056] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed in the embodiment description will be briefly introduced as follows. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can also be obtained by those skilled in the art without creative effort.

[0057] Fig. 1 shows a top view of a lyophilized material transfer mechanism.

[0058] Fig. 2 shows a structural schematic view of a lyophilized material transfer mechanism.

[0059] Fig. 3 shows a front view of a lyophilized material transfer mechanism.

[0060] Fig. 4 shows a schematic view of a second feeding and conveying assembly in a first feeding state.

[0061] Fig. 5 shows a schematic view of a second feeding and conveying assembly in a second feeding state.

[0062] Fig. 6 shows a schematic view of a second feeding and conveying assembly in a third feeding state.

[0063] Fig. 7 shows a schematic view of a second feeding and conveying assembly in a fourth feeding state.

[0064] Fig. 8 shows a structural schematic view of another side of a lyophilized material transfer mechanism.

[0065] Fig. 9 shows a side view of a lyophilized material transfer mechanism.

[0066] Fig. 10 shows a structural schematic view of a double-cavity pre-filled syringe production line.

[0067] Fig. 11 shows a flow schematic view of a production method of a double-cavity pre-filled syringe.

[0068] Fig. 12 shows a schematic view of a control device of a double-cavity pre-filled syringe production line.

[0069] Figure element description: 10 - freeze-dried material transfer mechanism, 100 - first upper feeding conveying assembly 100, 200 - second upper feeding conveying assembly, 210 - first driving mechanism, 220 - second driving mechanism, 230 - first screw, 240 - second screw, 241 - first upper feeding position, 242 - second upper feeding position, 300 - taking and placing assembly, 310 - taking and placing piece, 320 - driving piece, 321 - rotary driving piece, 322 - lifting driving piece, 330 - fixing frame, 340 - connecting piece, 350 - central shaft, 360 - air slide ring, 370 - support, 400 - freeze-dried mold collection tray, 500 - second detection mechanism, 600 - detection mechanism, A - first group of taking and placing units, B - second group of taking and placing units, C - third group of taking and placing units, D - fourth group of taking and placing units. 20 - pharmaceutical container supply unit, 21 - unpacking mechanism, 22 - carton paper heating mechanism, 23 - paper taking mechanism, 24 - nest plate taking mechanism, 25 - pharmaceutical container taking mechanism. 30 - freeze-dried material supply unit, 31 - freeze-dried mold feeding mechanism, 32 - front weighing mechanism, 33 - freeze-dried material filling mechanism, 34 - rear weighing mechanism, 35 - freeze-dried feeding mechanism, 36 - freeze-drying mechanism, 37 - capping mechanism. 40 - filling unit, 41 - first sealing mechanism, 42 - filling mechanism, 43 - second sealing mechanism, 44 - first detection mechanism, 45 - first turnover mechanism, 46 - freeze-dried material pre-assembly machine, 47 - third sealing mechanism. 50 - discharge unit, 51 - adapter mounting mechanism, 52 - cap mounting mechanism, 53 - pharmaceutical container turnover mechanism, 54 - back pushing mounting mechanism, 55 - discharge mechanism. 60 - pharmaceutical container. 70 - control device of the double-cavity pre-filled syringe production line, 71 - processor, 72 - memory. DETAILED DESCRIPTION

[0070] The technical solutions in the embodiments of the present application will be described clearly and completely below in combination with the drawings in the embodiments of the present application. Obviously, the described embodiments are only some of the embodiments of the present application, not all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work are within the scope of protection of the present application. In addition, it should be understood that the specific embodiments described herein are only used to illustrate and explain the present application, and are not used to limit the present application. In the present application, the orientation words such as "upper", "lower", "left", "right" generally refer to the upper, lower, left and right of the device in the actual use or working state, and specifically refer to the direction of the drawing surface in the drawings.

[0071] In addition, the terms "first", "second", etc. are used only for descriptive purposes and are not to be construed as indicating or implying relative importance or an indicated number of technical features. Thus, features defined with "first", "second", etc. can explicitly or implicitly include at least one of the features.

[0072] The present application provides a lyophilized material transfer mechanism, a double-cavity pre-filled syringe production line, a production method, a control device and a storage medium, which are described in detail below. It should be noted that the order of description of the following embodiments is not limited as the preferred order of the embodiments of the present application. In the following embodiments, the description of each embodiment has its own emphasis, and the parts not described in detail in a certain embodiment can be referred to the related description of other embodiments.

[0073] Please refer to FIG. 1, the embodiment of the present application provides a lyophilized material transfer mechanism 10, which comprises a first feeding conveying assembly 100, a second feeding conveying assembly 200 and a taking and placing assembly 300.

[0074] The first feeding conveying assembly 100 is used for feeding the medical container 60, for example, the medical container 60 after being flipped by the first flipping mechanism 45 is conveyed by the first feeding conveying assembly 100 to one side of the taking and placing assembly 300. The related content of the first flipping mechanism 45 will be described later. Of course, it can be understood that in the case where the first flipping mechanism 45 is not provided, the first feeding conveying assembly 100 can convey the medical container 60 from the upstream to one side of the taking and placing assembly 300. The first feeding conveying assembly 100 can comprise a conveying line and the like.

[0075] The second feeding conveying assembly 200 is used for feeding the lyophilized material, which can comprise a conveying line and the like. For example, the lyophilized material from the lyophilized material supply unit 30 is conveyed to one side of the taking and placing assembly 300. The related content of the lyophilized material supply unit 30 will be described later.

[0076] Here, for example, the conveying direction of the first feeding conveying assembly 100 and the conveying direction of the second feeding conveying assembly 200 are parallel, and in the illustrated state of FIG. 1, the conveying directions of both are from left to right. The first feeding conveying assembly 100 and the second feeding conveying assembly 200 are respectively located on both sides of the taking and placing assembly 300, so as to save space and facilitate the taking and placing assembly 300 to fill the lyophilized material into the medical container 60. Of course, the example of the present embodiment does not constitute an improper limitation, and in other embodiments, the first feeding conveying assembly 100 and the second feeding conveying assembly 200 can also be located at other positions, for example, on the same side of the taking and placing assembly 300, or on the adjacent sides of the taking and placing assembly 300, etc.

[0077] Here, please refer to FIG. 2, the second feeding conveying assembly 200 comprises a first screw 230 and a second screw 240 coaxially arranged, please refer to FIG. 3, the second feeding conveying assembly 200 further comprises a first driving mechanism 210 and a second driving mechanism 220. The first driving mechanism 210 is drivingly connected to the first screw 230, the second driving mechanism 220 is drivingly connected to the second screw 240, the first screw 230 and the second screw 240 are adjacently arranged along the conveying direction of the second feeding conveying assembly 200, so as to realize the function of spiral conveying. The first driving mechanism 210 and the second driving mechanism 220 can be arranged on a fixed frame 330. Here, exemplarily, a transfer conveying line can also be arranged on the upstream side of the first screw 230, so as to supply the first screw 230 with materials.

[0078] Specifically, taking the first screw 230 as an example, the adjacent two blades of the first screw 230 form a containing position for containing the freeze-dried materials, under the driving of the first driving mechanism 210, the first screw 230 rotates a set angle and makes the freeze-dried materials move forward by one stroke, thereby realizing the spiral conveying of the freeze-dried materials. Similarly, the adjacent two blades of the second screw 240 also form a containing position for containing the freeze-dried materials, under the driving of the second driving mechanism 220, the second screw 240 rotates a set angle and makes the freeze-dried materials move forward by one stroke, thereby realizing the spiral conveying of the freeze-dried materials. In fact, the essence is to split a spiral conveying rod into the first screw 230 and the second screw 240 adjacently arranged.

[0079] Therefore, under the condition that the first screw 230 and the second screw 240 rotate synchronously, the freeze-dried materials can be continuously conveyed forward. In some cases, if the rotation number of the first screw 230 and the second screw 240 is adjusted, so that the rotation number of the second screw 240 is greater than that of the first screw 230, differential conveying can be realized, so as to cooperate with the subsequent taking and placing assembly 300 to move the freeze-dried materials.

[0080] For example, the rotation frequency of the second screw 240 is set to be twice that of the first screw 230, at this time, the first screw 230 rotates one circle to make a portion of freeze-dried materials move forward by one stroke and be conveyed to the second screw 240, while for the second screw 240, it rotates two circles to make the previous portion of freeze-dried materials at the original position of the portion of freeze-dried materials move forward by two strokes, thereby forming an empty containing position between the previous portion of freeze-dried materials and the portion of freeze-dried materials.

[0081] In the present embodiment, the second screw 240 of the second feeding conveying assembly 200 includes two feeding positions, which can be any two accommodation positions of the second screw 240 for accommodating the freeze-dried materials. For example, they can be two accommodation positions for accommodating the freeze-dried materials formed between the three blades farthest from one end of the second screw 240.

[0082] Please see FIG. 4, the present embodiment defines the two feeding positions as a first feeding position 241 and a second feeding position 242, the first feeding position 241 is located downstream of the second feeding position 242, that is, the first feeding position 241 is located on the side of the second feeding position 242 away from the first screw 230. Thus, by controlling the number of rotations of the second screw 240 and the first screw 230, the second screw 240 can have four feeding states, namely a first feeding state, a second feeding state, a third feeding state, and a fourth feeding state.

[0083] In the first feeding state, the first feeding position 241 and the second feeding position 242 both have freeze-dried materials. For example, when feeding two adjacent freeze-dried materials, the number of rotations of the second screw 240 and the first screw 230 can be made consistent.

[0084] Please see FIG. 5, in the second feeding state, the first feeding position 241 does not have freeze-dried materials, and the second feeding position 242 has freeze-dried materials. For example, before feeding a freeze-dried material to the second screw 240, the second screw 240 is made to rotate one more revolution than the first screw 230.

[0085] Please see FIG. 6, in the third feeding state, the first feeding position 241 has freeze-dried materials, and the second feeding position 242 does not have freeze-dried materials. For example, after feeding a freeze-dried material to the second screw 240, the second screw 240 is made to rotate one more revolution than the first screw 230.

[0086] Please see FIG. 7, in the fourth feeding state, the first feeding position 241 and the second feeding position 242 both do not have freeze-dried materials. For example, the second screw 240 can be made to rotate one revolution, while the first screw 230 does not rotate.

[0087] It can be understood that the present embodiment is described by taking an example of the second screw 240 including two feeding positions, but the second screw 240 itself can have more accommodation positions for accommodating freeze-dried materials. In addition, in other embodiments, the second screw 240 can also have other numbers of feeding positions, such as three, four, five, etc. Moreover, in other embodiments, the second screw 240 can also not have a fourth feeding state, etc. The examples in the present embodiment do not constitute undue limitations.

[0088] In the embodiment, referring to FIG. 1 again, the taking and placing assembly 300 comprises at least one set of taking and placing units, and each set of taking and placing units comprises at least one taking and placing piece 310. For example, the taking and placing assembly 300 has four sets of taking and placing units, i.e., a first set of taking and placing units A, a second set of taking and placing units B, a third set of taking and placing units C, and a fourth set of taking and placing units D, and the four sets of taking and placing units are arranged uniformly along the circumferential direction, i.e., the included angle between two adjacent sets of taking and placing units is substantially a right angle.

[0089] Here, the position and the number of the taking and placing pieces 310 in each set of taking and placing units correspond to the feeding positions of the second screw 240. For example, the number of the taking and placing pieces 310 in each set of taking and placing units is also two, and corresponds to the positions of the two feeding positions of the second screw 240, which is also described below with the case that the second screw 240 has two feeding positions. That is, the two taking and placing pieces 310 are arranged in sequence along the arrangement direction of the feeding positions, and can be used to take and place the freeze-dried materials at the two feeding positions at the same time. It can be understood that when the number of the feeding positions is three, four, five, etc., the number of the taking and placing pieces 310 in each set of taking and placing units is correspondingly three, four, five, etc.

[0090] Referring to FIG. 8, the taking and placing assembly 300 further comprises a rotating driving piece 321 which is drivingly connected to the taking and placing units, so as to drive the taking and placing pieces 310 of the taking and placing units to rotate. The rotating driving assembly can be a motor, etc., which can be drivingly connected to the taking and placing assembly 300 through a reduction box, a bevel gear transmission mechanism, etc. Thus, the taking and placing assembly 300 can be driven to rotate by the rotating driving piece 321. It can be understood that in FIGS. 2 and 8, the first feeding and conveying assembly 100 is not shown in order to facilitate the observation of the relative position relationship between the taking and placing pieces 310 and the medicinal containers 60.

[0091] Here, the taking and placing assembly 300 has four stations, i.e., a first station, a second station, a third station, and a fourth station. When the taking and placing assembly 300 is driven to rotate by the rotating driving piece 321, each set of taking and placing units can be switched among the four stations. For example, the first station, the second station, the third station, and the fourth station are arranged uniformly in sequence along the circumferential direction, i.e., the included angle between two adjacent stations is substantially 90 degrees. Of course, in other embodiments, the arrangement positions of the four stations can be different according to actual requirements, and the present embodiment does not constitute an improper limitation thereto.

[0092] Here, the movement process of each set of taking and placing units is the same, and the movement process of one set of taking and placing units is exemplarily described below.

[0093] At the first station, the taking and placing elements 310 of the set of taking and placing units correspond to the feeding position of the second screw 240, and the taking and placing elements 310 can take the freeze-dried material at the feeding position. For example, the taking and placing elements 310 are vacuum suction elements that take the freeze-dried material at the feeding position by vacuum suction. For example, the position of the first set of taking and placing units A in FIG. 1 is the position of the first station.

[0094] At the second station, the second detection mechanism 500 is arranged to detect whether the taking and placing elements 310 have taken the freeze-dried material. For example, the second detection mechanism 500 is a visual detection mechanism such as a camera, and of course, in other embodiments, it can also be other infrared detection mechanisms, and the present embodiment does not constitute an improper limitation. In addition, for example, the set of taking and placing units can be rotated by about 90 degrees from the previous state to rotate from the first station to the second station. For another example, the position of the second set of taking and placing units B in FIG. 1 is the position of the second station.

[0095] At the third station, the set of taking and placing units moves to a position corresponding to the first feeding conveying assembly 100 and corresponding to the position of the medical containers 60 on the first feeding conveying assembly 100, for example, to the upper side of the first feeding conveying assembly 100. The arrangement of the medical containers 60 on the first feeding conveying assembly 100, the arrangement of the feeding position of the second feeding conveying assembly 200, and the arrangement of the taking and placing elements 310 in each set of taking and placing units correspond to each other. Thus, when rotated to the third station, the taking and placing elements 310 of the set of taking and placing units can place the freeze-dried material into the corresponding medical containers 60. In addition, for example, the set of taking and placing units can be rotated by about 90 degrees from the previous state to rotate from the second station to the third station. For another example, the position of the third set of taking and placing units C in FIG. 1 is the position of the third station.

[0096] At the fourth station, which is a cleaning station. For example, the position of the fourth set of taking and placing units D in FIG. 1 is the position of the fourth station. At this time, since the particles of the freeze-dried material can fall off, the taking and placing assembly 300 can be attached with a part of the particles of the freeze-dried material, thereby causing the taking and placing assembly 300 to be contaminated and possibly causing the particles of the freeze-dried material to be attached to the subsequent freeze-dried material during subsequent use, thereby affecting the quality of the subsequent freeze-dried material. Especially when the taking and placing elements 310 are vacuum suction elements, the particles of the freeze-dried material can continue to block the air path of the vacuum suction.

[0097] To this end, at the fourth station, the set of pick-and-place units will be cleaned. For example, when the pick-and-place piece 310 is a vacuum suction accessory, the air path is cleaned by controlling the pick-and-place piece 310 to spray air outward. Exemplarily, a collection container can also be provided at the fourth station, and the pick-and-place pieces 310 of the set of pick-and-place units can be moved to a position corresponding to the collection container and sprayed to spray the particles of the freeze-dried material and the like into the collection container. Of course, in other embodiments, the cleaning station can also be provided with other structures and other ways to clean, such as a brush that can reciprocate to clean the pick-and-place piece 310, a high-pressure spray head and a drying device to clean by high-pressure liquid and then dry, and the like. The examples in the present embodiment do not constitute undue limitations on the present application.

[0098] It can be understood that four sets of pick-and-place units are provided and four stations are provided, and in actual work, a set of pick-and-place units is working at each station, thereby ensuring the continuity of the work of the pick-and-place assembly 300 and improving the work efficiency. However, in other embodiments, the number of pick-and-place units and stations can not correspond, such as only one set, two sets or other number of sets of pick-and-place units, and the like. In addition, the above is exemplarily described by providing four stations, and in other embodiments, only the first station and the third station can be provided, or the fourth station is not provided, and the like. The examples in the present embodiment do not constitute undue limitations on the present application.

[0099] It can be understood that the present embodiment is exemplarily described by providing the rotary driving piece 321, but in other embodiments, according to actual needs, the rotary driving piece 321 can be replaced by other linear displacement driving piece, curve displacement driving piece or other driving piece 320, as long as the driving piece 320 can drive the pick-and-place piece 310 of the pick-and-place unit to move between the first feeding conveying assembly 100 and the second feeding conveying assembly 200 to feed the freeze-dried material to the pharmaceutical container 60. The examples in the present embodiment do not constitute undue limitations on the present application. In addition, the above embodiment is exemplarily described by driving each set of pick-and-place units by the driving piece 320, and in other embodiments, the driving piece 320 can drive each pick-and-place piece 310. The examples in the present embodiment do not constitute undue limitations on the present application.

[0100] In addition, referring to FIG. 8 again, the driving piece 320 of the freeze-dried material moving and picking mechanism 10 can further include a lifting driving piece 322 connected to the pick-and-place unit for driving the pick-and-place piece 310 of the pick-and-place unit to lift.

[0101] Exemplarily, the connecting member 340 can be provided, and the taking and placing assembly 300 is arranged on the connecting member 340. The connecting member 340 can be an integral structure or a structure formed by connecting a plurality of connecting blocks. The lifting driving member 322 can be a motor or a telescopic cylinder, etc. For example, when the lifting driving member 322 is a motor, it is sequentially connected to a speed reducer and a lead screw to transmit power to the connecting member 340, so as to drive the connecting member 340 and the taking and placing assembly 300 on the connecting member 340 to ascend and descend in the vertical direction. For another example, when the lifting driving member 322 is a telescopic cylinder, it is directly or indirectly connected to the connecting member 340, so as to drive the connecting member 340 and the taking and placing assembly 300 on the connecting member 340 to ascend and descend in the vertical direction. Of course, in other embodiments, the lifting driving member 322 can also be of other structures, and the lifting driving member 322 can also be directly or indirectly connected to the taking and placing assembly 300 through other manners, as long as it can drive the taking and placing assembly 300 to ascend and descend. For example, the lifting driving member 322 can include a telescopic cylinder arranged corresponding to each taking and placing member 310 or each group of taking and placing units. The examples in the present embodiment do not constitute improper limitation thereto.

[0102] Thus, the lifting driving member 322 can drive the taking and placing member 310 to ascend and descend. For example, when the taking and placing member 310 is located at the first station, the taking and placing member 310 is driven and moved downward to obtain the freeze-dried material, and then is moved upward to reset. For another example, when the taking and placing member 310 is located at the third station, the taking and placing member 310 is driven and moved downward to place the freeze-dried material, and then is moved upward to reset. Of course, when there is no need to ascend and descend, the lifting driving member 322 can also not be provided. The examples in the present embodiment do not constitute improper limitation thereto.

[0103] In addition, in the second station or the fourth station, the taking and placing member 310 can also be moved to the required corresponding position through lifting, such as the detection position of the second station or the cleaning position of the fourth station. Of course, in other embodiments, the detection position of the second station or the cleaning position of the fourth station can also be arranged at the position before descending. The examples in the present embodiment do not constitute improper limitation thereto.

[0104] Here, refer to FIG. 8 for example, the pick-and-place assembly 300 has a central shaft 350, the pick-and-place unit is connected to the central shaft 350, and the central shaft 350 is rotatably connected to the connecting member 340 and in transmission connection with the rotary drive 321. The lifting drive 322 is arranged on a fixed frame 330, and the lifting drive 322 is directly or indirectly connected to the pick-and-place unit, for example, the lifting drive 322 is connected to the connecting member 340. When the lifting drive 322 drives the connecting member 340 to lift, the rotary drive 321 and the pick-and-place unit are also lifted. Here, the first drive mechanism 210 and the second drive mechanism 220 described above can also be arranged on the fixed frame 330. It can be understood that in other embodiments, the first drive mechanism 210, the second drive mechanism 220, and the lifting drive 322 can also be arranged on different fixed frames 330, respectively, and the present embodiment does not unduly limit them.

[0105] Of course, in other embodiments, the rotary drive 321 can be connected to the connecting member 340 to drive the connecting member 340 to rotate as a whole, and the lifting drive 322 can be arranged on the connecting member 340, and the pick-and-place assembly 300 is in transmission connection with the lifting drive 322 and is liftably connected to the connecting member 340, which can also achieve similar technical effects, and the examples in the present embodiment do not unduly limit them.

[0106] Through the cooperation of the rotary drive 321 and the lifting drive 322, a compact structure design is achieved, which helps to reduce the occupied space of the overall structure and improve the working efficiency. Especially the arrangement of the rotary drive 321 and the four stations arranged uniformly in the circumferential direction effectively improves the working efficiency.

[0107] In the embodiment in which the rotary drive 321 is arranged and the pick-and-place member 310 is a vacuum suction accessory, the pick-and-place assembly 300 has a central shaft 350, and the central shaft 350 is arranged with a gas slip ring 360 and connected to a support 370 through the gas slip ring 360. The vacuum source is in gas communication with the gas slip ring 360 through a pipeline, and the gas slip ring 360 is in gas communication with each vacuum suction accessory through a pipeline to provide positive pressure or negative pressure for each vacuum suction accessory. The vacuum source can be a pump or the like. The gas slip ring 360 can realize gas path communication in the rotating state. The gas slip ring 360 is a structure for realizing gas path sealing and communication, which is prior art in the field of gas path communication, and the present embodiment does not make undue repetition.

[0108] Here, the vacuum suction method can effectively and conveniently realize the pick-and-place and movement of the freeze-dried materials, improve the pre-loading efficiency of the freeze-dried materials, and will not damage the freeze-dried materials, which helps to ensure the feeding quality of the freeze-dried materials.

[0109] In some embodiments, in order to make the connection 340 and the pick-and-place assembly 300 have better collimation when lifting, a guide post and a guide sleeve can also be provided. The fixed frame 330 does not move with the driving of the lifting drive 322 and the rotating drive 321. One of the guide post and the guide sleeve is connected to the fixed frame 330, and the other is connected to the connection 340, and the guide post is fitted in the guide sleeve, the guide post extends along the direction in which the connection 340 lifts, which is generally the vertical direction. Thus, when the lifting drive 322 drives the connection 340 to lift, the guide post also lifts with the connection 340, and the guide effect is achieved based on the cooperation with the guide sleeve, so that the lifting of the connection 340 and the pick-and-place assembly 300 is more stable and collimated.

[0110] In some embodiments, referring to FIGS. 8 and 9, a detection mechanism 600 can also be provided, which can be used to detect whether the liquid in the pharmaceutical container 60 meets the preset standard. For example, the detection mechanism 600 can be a liquid weighing mechanism, a visual detection mechanism, etc., which is used to detect whether the weight of the liquid meets the preset standard or whether the liquid level of the liquid meets the standard, etc. Exemplarily, the detection result of the detection mechanism 600 can be used to control the second feeding conveying mechanism. Here, the detection mechanism 600 can be provided at the freeze-dried material picking mechanism 10, and when the freeze-dried material picking mechanism 10 is applied to a production line or other structure, the detection mechanism 600 can also be provided at other positions upstream of the freeze-dried material picking mechanism 10.

[0111] Thus, when it is detected according to the detection result of the detection mechanism that the liquid in the pharmaceutical container 60 does not meet the preset standard, the feeding of the freeze-dried material is not performed for the corresponding pharmaceutical container 60. For example, when the two consecutive pharmaceutical containers 60 both meet the standard, the second feeding conveying mechanism is controlled to be in the first feeding state; when the previous pharmaceutical container 60 does not meet the standard and the subsequent pharmaceutical container 60 meets the standard, the second feeding conveying mechanism is controlled to be in the second feeding state described above; when the previous pharmaceutical container 60 meets the standard and the subsequent pharmaceutical container 60 does not meet the standard, the second feeding conveying mechanism is controlled to be in the third feeding state described above; and when the two consecutive pharmaceutical containers 60 both do not meet the standard, the second feeding conveying mechanism is controlled to be in the fourth feeding state.

[0112] Through this arrangement, it can be effectively achieved that the freeze-dried material is only put into the pharmaceutical container 60 that meets the standard, and the pharmaceutical container 60 that does not meet the standard can be more conveniently moved to the waste collection area at the subsequent station, and the loss of the freeze-dried material is reduced. For example, at the subsequent station, the pharmaceutical container 60 that does not meet the standard is clamped by a mechanical hand or moved to the waste collection area by a conveying line.

[0113] In some embodiments, since the freeze-drying material is placed in the freeze-drying mold and fed, in order to collect the empty freeze-drying mold after the feeding of the freeze-drying material is completed, the end of the second feeding conveying mechanism can also be provided with a freeze-drying mold collecting tray 400, and the second feeding conveying mechanism can convey the empty freeze-drying mold to the freeze-drying mold collecting tray 400.

[0114] Correspondingly, in order to better achieve the technical effects of the embodiments of the present application, the embodiments of the present application also provide a double-cavity pre-filled syringe production line. Please refer to FIG. 10, the double-cavity pre-filled syringe production line comprises a medicine container supply unit 20, a freeze-drying material supply unit 30, a filling unit 40 and a discharging unit 50. Of course, in some embodiments, it can also only comprise the filling unit 40.

[0115] Among them, the medicine container supply unit 20 and the freeze-drying material supply unit 30 are both arranged upstream of the filling unit 40, and the discharging unit 50 is arranged downstream of the filling unit 40.

[0116] The medicine container supply unit 20 is used to supply the filling unit 40 with medicine containers 60, and the freeze-drying material supply unit 30 is used to supply the filling unit 40 with freeze-drying materials. The filling unit 40 is used to load the medicine containers 60, for example, to fill the medicine containers 60 with liquid components, and to load the freeze-drying materials into the medicine containers 60. The discharging unit 50 is used to discharge the medicine containers 60 pre-filled with liquid components and freeze-drying materials into syringes.

[0117] Here, in some embodiments, the medicine container supply unit 20 can also be used to unpack the outer packaging loaded with the medicine containers 60 to take out the medicine containers 60 in the outer packaging.

[0118] Exemplarily, the syringe supply unit comprises, in sequence, an unpacking mechanism 21, a carton paper heating mechanism 22, a paper taking mechanism 23, a nest plate taking mechanism 24 and a medicine container taking mechanism 25.

[0119] The medicine containers 60 are usually contained in an outer packaging, which comprises an outermost packaging bag or packaging box, and the packaging bag or packaging box has a nest box therein, and the nest box is a honeycomb-shaped container having a plurality of containing positions arranged in an array, and each containing position contains a medicine container 60. The nest box has a nest plate substantially covering the nest box, and the nest plate can also be provided with carton paper.

[0120] In use, the unpacking mechanism 21 first unpacks the outer packaging bag or packaging box to take out the nest box. Then the sealing paper heating mechanism 22 heats the sealing paper, so that the paper taking structure can tear the sealing paper from the nest box. After the sealing paper is torn off, the nest plate taking mechanism 24 takes away the nest plate, and then the medicinal container 60 in the nest box is exposed. Thus, the medicinal container taking mechanism 25 can take out the medicinal container 60 in the nest box.

[0121] The unpacking mechanism 21, the sealing paper heating mechanism 22, the paper taking mechanism 23, the nest plate taking mechanism 24, and the medicinal container taking mechanism 25 can be mechanisms including a mechanical hand, and of course, existing mechanisms can also be used. For example, the unpacking mechanism 21 can be an existing automatic unpacking machine or a semi-automatic unpacking machine, etc. This is a selection of those skilled in the art according to actual needs, and the examples in the embodiments do not constitute undue limitations.

[0122] Here, according to actual needs, any of the unpacking mechanism 21, the sealing paper heating mechanism 22, the paper taking mechanism 23, and the nest plate taking mechanism 24 can not be provided. For example, when the packaging bag or the packaging box does not need to be unpacked, the unpacking mechanism 21 can not be provided. In the case where the unpacking mechanism 21, the sealing paper heating mechanism 22, the paper taking mechanism 23, and the nest plate taking mechanism 24 are not provided, the medicinal container supply unit 20 can basically only perform the operation of supplying the medicinal container 60 to the filling unit 40. The other operation steps can be completed by manual or by other equipment in advance. It can be understood that the examples in the embodiments do not constitute undue limitations on the present application.

[0123] The freeze-dried material supply unit 30 is used to supply freeze-dried materials to the filling unit 40. Here, in some embodiments, the freeze-dried material supply unit 30 can also be used to realize the preparation of freeze-dried materials.

[0124] Exemplarily, the freeze-dried material supply unit 30 can include a feeding subunit and a freeze-drying subunit.

[0125] Wherein, please refer to FIG. 10, the feeding subunit can include a freeze-drying mold feeding mechanism 31, a front weighing mechanism 32, a freeze-dried material filling mechanism 33, and a rear weighing mechanism 34.

[0126] The freeze-drying mold feeding mechanism 31 is used to realize the feeding of the freeze-drying mold, which is used to contain freeze-dried materials in the subsequent process. After the freeze-drying mold is fed, the front weighing mechanism 32 first weighs it, and then the freeze-dried material filling mechanism 33 fills the freeze-dried material into the freeze-drying mold. After the freeze-dried material is filled, the rear weighing mechanism 34 weighs the freeze-drying mold filled with the freeze-dried material.

[0127] The difference between the data weighed by the rear weighing mechanism 34 and the data weighed by the front weighing mechanism 32 is the weight of the filled drug solution. If the difference does not meet the preset weight range, the corresponding freeze-drying mold will be rejected before freeze-drying. For example, the processor 71 of the double-chamber pre-filled syringe production line records the position sequence number of the freeze-drying mold that does not meet the requirements, and when the freeze-drying mold is transported to the rejection station downstream of the rear weighing mechanism 34, the mechanical hand or other structure of the rejection station will take the freeze-drying mold away from the production line.

[0128] For the freeze-drying mold that meets the weighing requirements, it is transported to the freeze-drying sub-unit for freeze-drying operation.

[0129] Of course, in other embodiments, any of the freeze-drying mold feeding mechanism 31, the front weighing mechanism 32 and the rear weighing mechanism 34 can not be provided according to actual needs, and the examples in the present embodiment do not constitute undue limitation.

[0130] And the freeze-drying mold feeding mechanism 31 therein can be a material feeding disc, and the filling mechanism 42 can include a filling pump, and of course the examples in the present embodiment do not constitute undue limitation, and other structures can be used to realize the corresponding functions in other embodiments.

[0131] Please continue to refer to FIG. 10, the freeze-drying sub-unit includes a freeze-drying feeding mechanism 35, a freeze-drying mechanism 36 and a capping mechanism 37.

[0132] The freeze-drying mold filled with freeze-drying material described above is transported to the freeze-drying feeding mechanism 35, which can be a push rod mechanism, etc., which sends the freeze-drying mold into the freeze-drying mechanism 36 for freeze-drying.

[0133] The freeze-drying mechanism 36 can be a freeze-drying machine, etc., and the freeze-dried freeze-drying material is generally in the shape of a solid pencil, which can be called a powder cake, and of course the present embodiment does not limit the shape, etc. After the freeze-drying operation is completed, the freeze-dried freeze-drying material and the freeze-drying mold containing it can be transported to the filling unit 40 for subsequent operation.

[0134] Here, the capping mechanism 37 does not participate in the work, so in some embodiments, the capping mechanism 37 can not be provided. In other embodiments, in order to improve the applicability of the double-chamber pre-filled syringe production line, the capping mechanism 37 can be provided. Thus, the double-chamber pre-filled syringe production line can also be used to complete the production of other products. For example, by feeding a vial or other container through the freeze-drying mold feeding mechanism 31, filling the vial or other container with a drug solution through the freeze-drying material filling mechanism 33, and then feeding the vial or other container filled with the drug solution into the capping mechanism 37 for capping operation, for storage and transportation.

[0135] It can be understood that in other embodiments, according to actual conditions, any of the feeding subunit and the freeze-drying subunit can also not be arranged. For example, freeze-drying and other operations can be completed by other devices, in such a state, the double-cavity pre-filled syringe production line does not arrange the feeding subunit and the freeze-drying subunit, and the double-cavity pre-filled syringe production line itself can not have a freeze-drying function, it can be used only for feeding the freeze-dried material that has undergone freeze-drying operation to the filling unit 40, the above examples of the present embodiment do not constitute undue limitation on the present application.

[0136] Here, please continue to refer to FIG. 10, the filling unit 40 is used for filling liquid components in the medical container 60, and the freeze-dried material is loaded into the medical container 60.

[0137] Exemplarily, the filling unit 40 includes a liquid filling subunit and a freeze-dried material preloading subunit.

[0138] The liquid filling subunit includes a first sealing mechanism 41, a filling mechanism 42 and a second sealing mechanism 43 arranged in sequence.

[0139] The first sealing mechanism 41 is used for adding a first sealing body in the medical container 60, the filling mechanism 42 is used for filling liquid, such as diluent, in the space on the upper side of the first sealing body, and the second sealing mechanism 43 is used for adding a second sealing body in the medical container 60, and the first sealing body and the second sealing body form a liquid chamber that seals the diluent. It can be understood that for the double-cavity pre-filled syringe, one end of the communication channel is connected to the liquid chamber.

[0140] Here, the first sealing body and the second sealing body can be the same or different, for example, both the first sealing body and the second sealing body are rubber plugs, of course, in other embodiments, other structures can also be used without affecting the performance of the liquid and the subsequent freeze-dried material filled, for example, wooden plugs, metal plugs, etc., as long as they can form a liquid chamber for containing liquid, the examples in the present embodiment do not constitute undue limitation.

[0141] In some embodiments, the first detection mechanism 44 can also be provided to detect whether the filling amount of the liquid meets the preset standard. The first detection mechanism 44 can be provided on the same side, opposite side, downstream, etc. of the filling mechanism 42, as long as it can achieve the detection of the filling amount of the liquid. For example, the first detection mechanism 44 can include two liquid weighing mechanisms respectively provided upstream and downstream of the filling mechanism 42, and the liquid is weighed before and after filling to obtain the filling amount of the liquid, etc. The examples in this embodiment do not constitute undue limitations thereto. In addition, in some embodiments, the detection result of the first detection mechanism 44 can be used to control the freeze-dried material preloading subunit downstream thereof, for example, the first detection mechanism 44 is used as the aforementioned detection mechanism of the freeze-dried material transfer mechanism 10. Of course, in other embodiments, a detection mechanism can also be additionally provided at the freeze-dried material transfer mechanism 10, and the detection mechanism can also be a liquid weighing mechanism or other mechanism.

[0142] It can be understood that the liquid filling subunit can not be provided with the first sealing mechanism 41, for example, in the case that the pharmaceutical container 60 supplied to the liquid filling subunit is already provided with the first sealing body.

[0143] Please continue to refer to FIG. 10, the freeze-dried material preloading subunit includes a first turnover mechanism 45, a freeze-dried material preloading mechanism 46 and a third sealing mechanism 47 provided in sequence. Among them, the freeze-dried material preloading mechanism 46 can adopt the freeze-dried material transfer mechanism 10 introduced in the foregoing embodiments, the structure of which has been specifically described in the foregoing embodiments, and this embodiment will not be described in detail.

[0144] Among them, the first turnover mechanism 45 is used to turn over the pharmaceutical container 60, so that the side of the pharmaceutical container 60 for preloading freeze-dried material faces the freeze-dried material transfer mechanism 10. For example, the first turnover mechanism 45 is a mechanical hand, etc. Of course, in some embodiments, in the case that the pharmaceutical container 60 does not need to be turned over, the first turnover mechanism 45 can not be provided.

[0145] Here, the freeze-dried material transfer mechanism 10 is provided downstream of the liquid filling subunit, and of course in other embodiments, it can also be provided upstream of the liquid filling subunit.

[0146] It can be understood that in other embodiments, the filling unit 40 can also be used to load freeze-dried material into the pharmaceutical container 60, without being used to fill liquid components in the pharmaceutical container 60, for example, in the case that the pharmaceutical container supply unit 20 supplies the pre-rotation unit with a pharmaceutical container 60 which has been filled with liquid components. The examples in this embodiment do not constitute undue limitations thereto.

[0147] Here, as mentioned above, downstream of the lyophilized material transfer mechanism 10, a third sealing mechanism 47 is further provided, which is used to provide a third sealing body in the medical container 60 for sealing the lyophilized material. In the embodiment provided with the first turnover mechanism 45, a cavity for accommodating the lyophilized material is formed between the first sealing body and the third sealing body. It can be understood that for the double-cavity pre-filled syringe, one end of the communication channel is connected to the liquid cavity, and the other end is connected to the cavity.

[0148] Here, the third sealing body can be a rubber plug or the like, and of course in other embodiments it can also adopt other structures, such as a wooden plug, a metal plug, etc., as long as it can form a cavity for accommodating the lyophilized material, and the examples in the present embodiment do not constitute undue limitations.

[0149] In some embodiments, as mentioned above, for the double-cavity pre-filled syringe, the medical container 60 has a liquid cavity for accommodating liquid and a cavity for accommodating lyophilized material, and before use of the double-cavity pre-filled syringe, the two cavities are not communicated, otherwise the lyophilized material will be mixed with the liquid in advance under unnecessary conditions, thereby causing the failure to achieve its function.

[0150] To this end, the double-cavity pre-filled syringe production line is further provided with a third detection mechanism, which is located downstream of the lyophilized material transfer mechanism 10 and upstream of the third sealing mechanism 47, for detecting the communication state of the liquid cavity for accommodating liquid and the cavity for accommodating lyophilized material in the medical container 60. If the third detection mechanism detects that the two cavities of the medical container 60 have been communicated in advance, the medical container 60 will be removed as a defective product at the subsequent station. In this way, the yield of the double-cavity pre-filled syringe can be improved. Here, the third detection mechanism can be a visual detection mechanism, an infrared detection mechanism, etc., and the examples in the present embodiment do not constitute undue limitations.

[0151] Here, in some embodiments, in order to improve the cleanliness of the environment, a laminar flow hood is provided, and the liquid filling subunit and the lyophilized material preloading subunit are both arranged in the laminar flow hood and are under an A-level laminar flow environment. The airflow of the A-level laminar flow moves in the direction from the liquid filling subunit to the lyophilized material preloading subunit. Since the liquid filling subunit is arranged upstream of the lyophilized material preloading subunit in the present embodiment, the product yield can be better guaranteed. On the contrary, if the lyophilized material preloading subunit is arranged upstream of the liquid filling subunit, the particles of the lyophilized material are easy to fall off, especially under the A-level laminar flow environment, the particles of the lyophilized material are easy to be lifted by the A-level laminar flow and form dust pollution, and are easy to fall into the liquid downstream, thereby causing the product yield to decrease.

[0152] Here, please refer to Fig. 10, the outfeed unit 50 is used to receive the medical container 60 from the filling unit 40, at this time the medical container 60 has been pre-filled with the liquid component and the lyophilized material, the liquid component can be diluent, and the lyophilized material can be cake. Then, the outfeed unit 50 assembles the medical container 60 pre-filled with the liquid component and the lyophilized material into a syringe and outfeeds.

[0153] Exemplarily, the outfeed unit 50 can include an adapter mounting mechanism 51, a top cap mounting mechanism 52, a medical container overturning mechanism 53, a back push mounting mechanism 54, and an outfeed mechanism 55.

[0154] The medical container 60 has opposite first and second ends. The adapter mounting mechanism 51 first mounts an adapter on the first end of the syringe, and the adapter provides a conversion head. Then the top cap mounting mechanism 52 mounts a top cap on the adapter for protection.

[0155] Subsequently, the medical container overturning mechanism 60 overturns the medical container 60 by 180°, and the first and second ends of the medical container 60 are reversed. The back push mounting mechanism 54 can mount a back push on the second end of the medical container 60. The back push is a flange structure protruding outwardly at the second end position of the medical container 60, and in actual use of the syringe, the operator can press the back push with the index finger and middle finger, and press the plunger with the thumb to achieve injection. After the back push is mounted, the medical container 60 becomes a syringe without a plunger and a needle, and the outfeed mechanism 55 can outfeed it into a finished product collection container.

[0156] The adapter mounting mechanism 51, the top cap mounting mechanism 52, the medical container overturning mechanism 53, the back push mounting mechanism 54, and the outfeed mechanism 55 can be structures including a mechanical hand, of course, they can also be other structures, for example, the outfeed mechanism 55 can be an outfeed star wheel, etc.

[0157] It can be understood that in other embodiments, the outfeed unit 50 can also not be provided with any of the adapter mounting mechanism 51, the top cap mounting mechanism 52, the medical container overturning mechanism 53, and the back push mounting mechanism 54. For example, when the second end of the medical container 60 does not need to be additionally mounted with a back push, the medical container overturning mechanism 53 and the back push mounting mechanism 54 can not be provided; for example, by adjusting the setting position of the back push mounting structure, the medical container overturning mechanism 53 can not be provided and the medical container 60 can be overturned, etc. For example, in existing other types of syringe manufacturing production lines, there are usually structures for realizing corresponding functions such as adapter mounting, top cap mounting, and back push mounting, and the relevant structures can be used to realize the corresponding functions, and the double-chamber pre-filled syringe production line itself can not have the corresponding functions. In short, the examples in the present embodiment do not constitute undue limitations.

[0158] In addition, in some embodiments, the double-chamber pre-filled syringe production line can also be provided with a web transfer mechanism or other conveying mechanism such as a conveying line, which is used to realize the material conveying between units and / or between mechanisms of the units. The structure of the conveying mechanism itself and its application in various production lines are well known to those skilled in the art, and the present embodiment does not make too many limitations.

[0159] With the above arrangement, a complete double-chamber pre-filled syringe production line can be provided, thereby realizing a series of steps such as unpacking of the pharmaceutical containers 60, preparation of the freeze-dried material, assembly of the liquid such as the diluent and the freeze-dried material into the pharmaceutical containers 60, and assembly of the syringes, so as to effectively improve the production efficiency of the double-chamber pre-filled syringes and also help to improve the production quality.

[0160] In some embodiments, the double-chamber pre-filled syringe production line can also be used to produce other products, for example, it can be used to fill the pharmaceutical liquid into a vial and crimp the cap, and the aforementioned filling mechanism 42 or freeze-dried material filling mechanism 33 will be used. For the mechanisms that do not need to be used, the conveying line or other conveying mechanism can pass the vial along the production line through the mechanisms, and the mechanisms that do not need to be used do not work.

[0161] Correspondingly, in order to better achieve the technical effects of the embodiments of the present application, the embodiments of the present application also provide a production method of a double-chamber pre-filled syringe, please refer to FIG. 11, which includes the following steps:

[0162] S1. feeding the pharmaceutical containers 60 by the first feeding conveying assembly 100;

[0163] S2. feeding the freeze-dried material by the second feeding conveying assembly 200;

[0164] S3. moving and taking the freeze-dried material supplied by the second feeding conveying assembly 200 to the pharmaceutical containers 60 supplied by the first feeding conveying assembly 100 by the taking and placing assembly 300.

[0165] In some embodiments, the production method of the double-chamber pre-filled syringe can be implemented based on the aforementioned double-chamber pre-filled syringe production line or the production line with the aforementioned freeze-dried material moving and taking mechanism 10.

[0166] It can be understood that the serial numbers of the steps in the embodiments of the present application do not necessarily represent the order of their implementation. For example, step S1 and step S2 can be implemented synchronously, and the examples in the present embodiment do not constitute improper limitations.

[0167] In step S2, the second feeding conveying assembly 200 has four feeding states. In a first feeding state, the first feeding position 241 and the second feeding position 242 of the second feeding conveying assembly 200 both have the freeze-dried material; in a second feeding state, the first feeding position 241 has no freeze-dried material and the second feeding position 242 has the freeze-dried material; in a third feeding state, the first feeding position 241 has the freeze-dried material and the second feeding position 242 has no freeze-dried material; and in a fourth feeding state, the first feeding position 241 and the second feeding position 242 both have no freeze-dried material.

[0168] In some embodiments, the feeding pharmaceutical containers 60 are detected by a detection mechanism and detection results are obtained; in step S2, the feeding state of the second feeding conveying assembly 200 is switched according to the detection results.

[0169] In some embodiments, step S3 specifically includes:

[0170] S31. In the first station, the freeze-dried material supplied by the second feeding conveying assembly 200 is obtained by the taking and placing assembly 300;

[0171] S33. The taking and placing assembly 300 is rotated to the third station, and the freeze-dried material is placed in the pharmaceutical container 60.

[0172] In some embodiments, the following step is further provided before step S33:

[0173] S32. The taking and placing assembly 300 is rotated from the first station to the second station, and the freeze-dried material is detected by the second detection mechanism 500.

[0174] In some embodiments, the following step is further provided before step S33:

[0175] S34. The taking and placing assembly 300 is rotated from the third station to the fourth station, and air is sprayed outward in the fourth station to clean the air path of the taking and placing assembly 300.

[0176] In some embodiments, the following step is further provided before step S1: the pharmaceutical container 60 is filled with liquid, and a liquid chamber for accommodating the liquid is formed.

[0177] In some embodiments, the following step is further provided before step S1: the pharmaceutical container 60 is supplied by the pharmaceutical container supply unit 20. The pharmaceutical container 60 is usually a pharmaceutical container 60 that has been filled with liquid. Specific implementation examples have been described in the foregoing embodiments, and will not be described here.

[0178] In some embodiments, before step S2, a step of supplying the freeze-dried material by the freeze-dried material supply unit 30 is provided. The specific implementation examples have been described in the foregoing embodiments, and will not be repeated here.

[0179] In some embodiments, after step S3, the pre-filled syringe 60 pre-filled with the liquid component and the freeze-dried material is discharged by the discharge unit 50. The specific implementation examples have been described in the foregoing embodiments, and will not be repeated here.

[0180] Correspondingly, in order to better achieve the technical effects of the embodiments of the present application, referring to FIG. 12, the embodiments of the present application further provide a control device 70 of the double-chamber pre-filled syringe production line, which comprises the detection mechanism 600, the controller 71 and the aforementioned freeze-dried material transfer mechanism 10. The detection mechanism 600 is used to detect the pre-filled syringe 60 and obtain a detection result; the controller 71 is in signal connection with the freeze-dried material transfer mechanism 10 and the detection mechanism 600, and adjusts the feeding state of the second screw 240 of the freeze-dried material transfer mechanism 10 according to the detection result.

[0181] For example, when the detection result is that the two pre-filled syringes 60 in succession meet the standard, the controller controls the second feeding conveying mechanism to be in the first feeding state; when the detection result is that the previous pre-filled syringe 60 does not meet the standard and the subsequent pre-filled syringe 60 meets the standard, the controller controls the second feeding conveying mechanism to be in the aforementioned second feeding state; when the detection result is that the previous pre-filled syringe 60 meets the standard and the subsequent pre-filled syringe 60 does not meet the standard, the controller controls the second feeding conveying mechanism to be in the aforementioned third feeding state; and when the detection result is that the two pre-filled syringes 60 in succession do not meet the standard, the controller controls the second feeding conveying mechanism to be in the fourth feeding state.

[0182] In some embodiments, the controller controls the aforementioned double-chamber pre-filled syringe production line to produce the double-chamber pre-filled syringe according to the aforementioned double-chamber pre-filled syringe production method.

[0183] In some embodiments, the control device of the double-chamber pre-filled syringe production line further comprises a memory 72, the memory 72 is used to store a computer program, the processor 71 and the memory 72 are in signal connection, and the computer program is executed by the processor 71 to realize the aforementioned double-chamber pre-filled syringe production method.

[0184] Correspondingly, in order to better achieve the technical effects of the embodiments of the present application, the embodiments of the present application further provide a non-volatile computer readable storage medium, and the non-volatile computer readable storage medium stores a computer program, and the computer program is executed by a processor to realize the steps in the aforementioned double-chamber pre-filled syringe production method.

[0185] The specific limitations and implementation manners of the above steps can refer to the steps and methods of the embodiments of the production method of the double-chamber pre-filled syringe, which will not be repeated here. A person of ordinary skill in the art can understand that all or part of the processes in the above-mentioned embodiment methods can be completed by instructing the relevant hardware through a computer program, and the relevant computer program can be stored in a non-volatile computer readable storage medium. When the computer program is executed, it can include the processes of the above-mentioned embodiments of the method. Among them, any reference to memory, storage, database or other medium used in each embodiment provided by the present application can include non-volatile and / or volatile memory. Non-volatile memory can include read-only memory (ROM), programmable ROM (PROM), electrically programmable ROM (EPROM), electrically erasable programmable ROM (EEPROM) or flash memory. Volatile memory can include random access memory (RAM) or external cache memory. As an illustration but not limitation, RAM is available in various forms, such as static RAM (SRAM), dynamic RAM (DRAM), synchronous DRAM (SDRAM), double data rate SDRAM (DDR SDRAM), enhanced SDRAM (ESDRAM), synchronous link (Synchlink) DRAM (SLDRAM), memory bus (Rambus) direct RAM (RDRAM), direct memory bus dynamic RAM (DRDRAM), and memory bus dynamic RAM (RDRAM), etc.

[0186] Application examples

[0187] Here, an example of the use of the double-chamber pre-filled syringe production line in actual use is provided, and it can be understood that it does not constitute an undue limitation on the present application.

[0188] Here, the entire double-chamber pre-filled syringe production line is used under A-level laminar flow ring to ensure sterility.

[0189] First, the freeze-drying mold is on the freeze-drying mold feeding mechanism 31, which can include a feeding turntable and the like. The feeding turntable works together with the guardrails on the feeding turntable to arrange the freeze-drying molds in a single column. Then the freeze-drying molds are transferred to the front weighing mechanism 32 to complete the front weighing.

[0190] The freeze-drying mold is then transferred to a freeze-drying material filling mechanism 33, and the medicine liquid is filled into the freeze-drying mold through the freeze-drying material filling mechanism 33. The freeze-drying mold filled with the medicine liquid is then sent to a rear weighing mechanism 34, and the difference between the data weighed by the rear weighing mechanism 34 and the data weighed by the front weighing mechanism 32 is the weight of the filled medicine liquid. The freeze-drying mold that does not meet the required filling amount is rejected in the subsequent workstations. The freeze-drying mold that meets the requirement is sent to the entrance of a freeze-drying mechanism 36 through a transfer web belt. A freeze-drying feeding mechanism 35 feeds the freeze-drying mold into the freeze-drying mechanism 36, and after all the medicine liquid is fed into the freeze-drying mechanism 36, the door of the freeze-drying mechanism 36 is closed, and freeze-drying is performed.

[0191] In another aspect, the whole package of the medicine container 60 is sent to the unpacking mechanism 21 to be unpacked and the nest box is obtained. The conveying web belt conveys the nest box to the sealing paper heating mechanism 22, the sealing paper heating mechanism 22 makes the sealing paper and the heating part fully contact and heat, so that the paper taking mechanism 23 takes out the sealing paper. After the heating is completed, the conveying web belt transfers the nest box to the paper taking mechanism 23, the paper taking mechanism 23 is lowered, the sealing paper is taken out through the vacuum suction nozzle, and then the paper taking mechanism 23 is rotated to the waste paper collection place, the vacuum is broken, and the sealing paper is placed into the waste paper collection device. After the sealing paper is taken out, the paper taking mechanism 23 is rotated to the nest box again, and is lowered, the inner liner paper is sucked through the vacuum suction nozzle, is lifted and rotated to the waste paper collection place, and is placed into the waste paper collection device. Subsequently, the conveying web belt conveys the nest box to the downstream equipment.

[0192] The conveying web belt conveys the nest box to the nest plate taking mechanism 24, the nest plate taking mechanism 24 is lowered, and the nest plate is taken out of the nest box through the vacuum suction nozzle. The nest plate taking mechanism is rotated and then lowered, and the nest plate is placed in the nest plate transfer conveying line. The nest plate transfer conveying line transfers the nest plate to the nest removing position, and the medicine container taking mechanism 25 is lowered and sucks the medicine container 60 through the vacuum. Then the medicine container taking mechanism 25 is raised, the medicine container 60 is taken out of the nest plate, and the distance between the medicine containers 60 is pulled apart. The mechanism is rotated by 180°, lowered again, and the medicine containers 60 are placed into the medicine container 60 double-layer transfer web belt. Then the medicine container taking mechanism 25 breaks the vacuum, and is raised. The medicine container transfer web belt transfers the medicine containers 60 to the downstream equipment.

[0193] After all the medicine containers 60 are taken out, the nest plate transfer conveying line transfers the empty nest plate to the nest box taking mechanism, the nest box taking mechanism is lowered, the empty nest plate is taken out and placed in the empty nest box. The empty nest box and the empty nest plate are pushed into the empty nest box collection web belt by the pushing mechanism in the conveying web belt.

[0194] The medicine container feeding transfer web belt transfers the medicine containers 60 after the nests are removed in the upstream to the main web belt, and the main web belt transfers the medicine containers 60 to the first sealing mechanism 41 for adding the intermediate rubber stopper. The first sealing mechanism 41 adds the rubber stopper into the medicine container 60.

[0195] After the intermediate rubber plug is added, the medicine container 60 is transferred by the main web belt to the front weighing position of the second detection mechanism 500 for weighing.

[0196] Subsequently, the main web belt transfers the medicine container 60 to the filling mechanism 42, the filling mechanism 42 fills the diluent into the medicine container 60, and the main web belt transfers the medicine container 60 to the rear weighing position of the second detection mechanism 500 for rear weighing.

[0197] Then, the main web belt transports the medicine container 60 to the second sealing mechanism 43 for adding a rubber plug. After the rubber plug is added, the medicine container 60 is transferred to the reject star wheel, the reject star wheel sucks the medicine container 60 without a rubber plug or with unqualified weight by vacuum and transfers it to the reject channel, and the normal medicine container 60 is transferred to the downstream equipment by the discharge star wheel.

[0198] The medicine container 60 after the diluent is filled is transferred by the first feeding conveying assembly 100 such as a feeding star wheel and a web belt to the freeze-dried material picking mechanism 10, the first turnover mechanism 45 takes the medicine container 60 from the web belt, turns it by 180°, and puts it back on the web belt. The web belt transfers the medicine container 60 to the front weighing position of the detection mechanism 600 for weighing. The second feeding conveying assembly 200 including the transfer web belt transfers the freeze-dried product to the freeze-dried material picking mechanism 10, the 4-station freeze-dried material picking mechanism 10 is lowered, and the freeze-dried material is picked from the freeze-dried mold by vacuum. Then, the freeze-dried material picking mechanism 10 rotates, transfers the freeze-dried material to the third station, and puts the freeze-dried material into the medicine container 60.

[0199] Subsequently, the web belt transfers the medicine container 60 to the rear weighing position of the detection mechanism 600 for weighing. After the weighing is completed, the web belt transfers the medicine container 60 to the third sealing mechanism 47 to add a front rubber plug. Subsequently, the web belt transfers the finished product to the reject star wheel, the reject star wheel sucks the medicine container 60 without a powder cake, with unqualified weight of the powder cake, or without a front rubber plug by vacuum and transfers it to the reject channel. The qualified product is transferred to the discharge unit 50 by the discharge star wheel for assembly.

[0200] In the discharge unit 50, the medicine container 60 completes the installation of the adapter, the top cap, and the back push, and is then discharged by the discharge mechanism 55.

[0201] It can be understood that, except for special description, the meanings of the terms in the various embodiments of the present application are the same, and the specific implementation details of the contents not described in detail for a certain embodiment can be referred to the description in other embodiments, and the example illustration and technical effects shown by the foregoing embodiments can be correspondingly realized, and for the repeated parts, the present embodiment will not be described in detail.

[0202] The above provides a lyophilized material transfer mechanism, a double-cavity pre-filled syringe production line, a production method, a control device and a storage medium. The principles and implementation modes of the present application are described by applying specific examples. The above examples are only used to help understand the method and core idea of the present application. Meanwhile, for those skilled in the art, according to the idea of the present application, the specific implementation mode and application range will be changed. In summary, the content of the specification should not be understood as a limitation of the present application.

Claims

1. A lyophilized material transfer mechanism, comprising: comprising, a first feeding conveying assembly for feeding the medicinal containers; a second feeding conveying assembly for feeding the freeze-dried materials, the second feeding conveying assembly comprising a first driving mechanism, a second driving mechanism, and a first screw and a second screw coaxially arranged, the first driving mechanism being drivingly connected to the first screw, the second driving mechanism being drivingly connected to the second screw, the first screw and the second screw being adjacently arranged along a conveying direction of the second feeding conveying assembly; and a picking and placing assembly for picking and placing the freeze-dried materials fed by the second feeding conveying assembly into the medicinal containers fed by the first feeding conveying assembly.

2. The lyophilized material transfer mechanism of claim 1, wherein, The second screw is provided with a first feeding position and a second feeding position, the first feeding position being located downstream of the second feeding position, and the second screw is capable of adjusting feeding states of the first feeding position and the second feeding position through switching of a rotation frequency.

3. The lyophilized material transfer mechanism of claim 2, wherein, The second screw is capable of switching among four feeding states, wherein, in a first feeding state, both the first feeding position and the second feeding position have freeze-dried materials; in a second feeding state, the first feeding position has no freeze-dried materials, and the second feeding position has freeze-dried materials; in a third feeding state, the first feeding position has freeze-dried materials, and the second feeding position has no freeze-dried materials; in a fourth feeding state, both the first feeding position and the second feeding position have no freeze-dried materials.

4. The lyophilized material transfer mechanism of claim 3, wherein, Further comprising, a detection mechanism for detecting the fed medicinal containers and obtaining a detection result; the second feeding conveying assembly adjusts the feeding state of the second screw according to the detection result.

5. The lyophilized material transfer mechanism of claim 3, wherein, The picking and placing assembly comprises a driving member and at least one set of picking and placing units, the driving member being used to drive the picking and placing units to move between the first feeding conveying assembly and the second feeding conveying assembly, so as to feed the freeze-dried materials into the medicinal containers.

6. The lyophilized material transfer mechanism of claim 5, wherein, The driving member is capable of driving the picking and placing units to switch between a first station and a third station; in the first station, at least one set of the picking and placing units corresponds to the first feeding position and the second feeding position of the second screw, so as to obtain the freeze-dried materials; in the third station, at least one set of the picking and placing units corresponds to a position of the first feeding conveying assembly, so as to place the freeze-dried materials into the medicinal containers.

7. The lyophilized material dispensing mechanism of claim 6, wherein, The driving member is further capable of driving the picking and placing units to a second station, the second station being provided with a second detection mechanism for detecting the freeze-dried materials.

8. The lyophilized material transfer mechanism of claim 6, wherein, The driving member is further capable of driving the picking and placing units to a fourth station, the fourth station being a cleaning station.

9. The lyophilized material transfer mechanism of claim 6, wherein, Each set of the picking and placing units comprises two picking and placing members, and the arrangement positions of the two picking and placing members correspond to the arrangement positions of the first feeding position and the second feeding position.

10. The freeze-dried material picking and placing mechanism according to claim 6, wherein the driving member comprises a rotary driving member drivingly connected to the picking and placing units, so as to drive the picking and placing units to rotate and switch among a first station, a second station, a third station and a fourth station; the first station, the second station, the third station and the fourth station are uniformly arranged along a circumferential direction.

11. The lyophilized material dispensing mechanism of claim 8 or 10, wherein, The taking and placing unit comprises at least one taking and placing member, which is a vacuum suction member, and a collecting container is arranged at the fourth station to collect the sprayed material when the taking and placing member sprays air outward.

12. The lyophilized material transfer mechanism of claim 11, wherein, The taking and placing assembly further comprises a central shaft, a vacuum source and a support, the central shaft is connected to the support through a gas sliding ring, the vacuum source is in gas communication with the gas sliding ring, and the gas sliding ring is in gas communication with each vacuum suction member to provide positive pressure or negative pressure for each vacuum suction member.

13. The lyophilized material transfer mechanism of claim 10, wherein, The taking and placing assembly comprises four groups of taking and placing units, which are uniformly arranged along the circumference.

14. The lyophilized material transfer mechanism of claim 10, wherein, The driving member further comprises a lifting driving member connected to the taking and placing unit to drive the taking and placing unit to lift.

15. The lyophilized material transfer mechanism of claim 14, wherein, Further comprising a connecting member, the rotating driving member is arranged on the connecting member, the taking and placing assembly has a central shaft, the taking and placing unit is connected to the central shaft, the central shaft is rotatably connected to the connecting member and in transmission connection with the rotating driving member, and the lifting driving member is connected to the connecting member to drive the connecting member, the rotating driving member and the taking and placing unit to lift.

16. A dual chamber pre-filled syringe line, characterized in that, The filling unit comprises, a first sealing mechanism for arranging a first sealing body in the medical container; a filling mechanism arranged downstream of the first sealing mechanism, the filling mechanism being configured to fill the medical container with a liquid; a second sealing mechanism arranged downstream of the filling mechanism, the second sealing mechanism being configured to arrange a second sealing body in the medical container, the first sealing body and the second sealing body forming a liquid chamber for accommodating the liquid therebetween; the freeze-dried material transfer mechanism according to any one of claims 1 to 15 is arranged downstream of the second sealing mechanism to add freeze-dried material into the medical container; a third sealing mechanism arranged downstream of the freeze-dried material transfer mechanism to arrange a third sealing body in the medical container for sealing the freeze-dried material.

17. The dual-chamber pre-filled syringe production line according to claim 16, wherein, a first overturning mechanism is further arranged downstream of the second sealing mechanism and upstream of the freeze-dried material transfer mechanism, the first overturning mechanism being configured to overturn the medical container; the first sealing body and the third sealing body form a chamber for accommodating the freeze-dried material therebetween.

18. The dual chamber pre-filled syringe line of claim 16, wherein, Further comprising a laminar flow hood, the first sealing mechanism, the filling mechanism, the second sealing mechanism and the freeze-dried material transfer mechanism are arranged in the laminar flow hood and in an A-level laminar flow environment.

19. The dual chamber pre-filled syringe line of claim 16, wherein, Further comprising, a medical container supply unit arranged upstream of the filling unit to supply the filling unit with medical containers; a freeze-dried material supply unit arranged upstream of the filling unit to supply the filling unit with freeze-dried material; and a discharge unit arranged downstream of the filling unit to discharge the medical containers pre-assembled with the liquid component and the freeze-dried material into syringes. The method comprises the following steps, 20. A method of producing a dual chamber pre-filled syringe, characterized by, feeding the medical containers by the first feeding conveying assembly; feeding the freeze-dried material by the second feeding conveying assembly; ​ The freeze-dried material supplied by the second feeding and conveying assembly is moved to the medicinal containers supplied by the first feeding and conveying assembly by a pick-and-place assembly; The second feeding and conveying assembly has four feeding states. In the first feeding state, the first feeding position and the second feeding position of the second feeding and conveying assembly both have freeze-dried material. In the second feeding state, the first feeding position has no freeze-dried material, and the second feeding position has freeze-dried material. In the third feeding state, the first feeding position has freeze-dried material, and the second feeding position has no freeze-dried material. In the fourth feeding state, the first feeding position and the second feeding position both have no freeze-dried material.

21. The method of producing a dual chamber pre-filled syringe according to claim 20, wherein The medicinal containers are detected by a detection mechanism, and detection results are obtained. The feeding state of the second feeding and conveying assembly is switched according to the detection results.

22. The method of producing a dual chamber pre-filled syringe according to claim 20, wherein The step of moving the freeze-dried material supplied by the second feeding and conveying assembly to the medicinal containers supplied by the first feeding and conveying assembly by the pick-and-place assembly specifically includes, In the first station, the pick-and-place assembly obtains the freeze-dried material supplied by the second feeding and conveying assembly. The pick-and-place assembly is rotated to the third station, and the freeze-dried material is placed in the medicinal containers.

23. The method of producing a dual chamber pre-filled syringe according to claim 22, wherein Before the step of rotating the pick-and-place assembly to the third station and placing the freeze-dried material in the medicinal containers, the pick-and-place assembly is rotated to the second station, and the freeze-dried material is detected by a second detection mechanism.

24. The method of producing a dual chamber pre-filled syringe according to claim 22, wherein The pick-and-place assembly moves the freeze-dried material by vacuum adsorption. After the step of rotating the pick-and-place assembly to the third station and placing the freeze-dried material in the medicinal containers, the pick-and-place assembly is rotated to the fourth station, and air is sprayed outward at the fourth station to clean the air path of the pick-and-place assembly.

25. The method of producing a dual chamber pre-filled syringe according to claim 20, wherein, Before the step of feeding the medicinal containers by the first feeding and conveying assembly, the medicinal containers are filled with a liquid, and a liquid chamber for containing the liquid is formed.

26. The production method of the dual-chamber pre-filled syringe according to claim 20, wherein, Before the step of feeding the medicinal containers by the first feeding and conveying assembly, the medicinal containers are supplied by a medicinal container supply unit; Before the step of feeding the freeze-dried material by the second feeding and conveying assembly, the freeze-dried material is supplied by a freeze-dried material supply unit; After the step of moving the freeze-dried material supplied by the second feeding and conveying assembly to the medicinal containers supplied by the first feeding and conveying assembly by the pick-and-place assembly, the medicinal containers pre-filled with the liquid component and the freeze-dried material are assembled into syringes by an ejection unit.

27. A control device for a dual chamber pre-filled syringe production line, characterized in that, The freeze-dried material moving mechanism according to any one of claims 1 to 15; The detection mechanism is configured to detect the medicinal containers and obtain detection results. The controller is signal-connected to the freeze-dried material moving mechanism and the detection mechanism, and adjusts the feeding state of the second screw of the freeze-dried material moving mechanism according to the detection results. ​ 28. A non-transitory computer readable storage medium, comprising: The non-transitory computer readable storage medium has stored thereon a computer program that, when executed by a processor, implements the steps of the method of producing a dual chamber pre-filled syringe of any one of claims 20 to 26.

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