A herbicidal combination

Abstract

The present disclosure relates to a herbicidal combination comprising a carbamate herbicide and a diphenyl ether herbicide.

Description

[0001] A HERBICIDAL COMBINATION

[0002] FIELD OF THE DISCLOSURE:

[0003] The present disclosure relates to a herbicidal combination comprising a carbamate herbicide and a diphenyl ether herbicide. Furthermore, the present disclosure relates to a method for controlling weeds by applying an effective amount of the herbicidal combination thereof.

[0004] BACKGROUND OF THE DISCLOSURE:

[0005] Herbicides are chemical substances, which are used to control unwanted plants / weeds. The mode of action for herbicides is a biochemical or a physical mechanism, which disrupts or alters one or more of the metabolic processes of the unwanted plants / weed, thereby controlling their growth. Therefore, when and how any herbicide should be applied may be determined by the mode of action of the herbicide.

[0006] Furthermore, there are certain species or groups of unwanted plants / weeds, which are susceptible to certain herbicides and not susceptible to certain herbicides. This may be because either the herbicides use different biochemical pathways, or the herbicides have slightly different enzymes. In situations where one herbicide is ineffective, additional herbicide(s) with different modes of action may provide better results.

[0007] Asulam, also known as methyl A-(4-aminophenyl)sulfonylcarbamate), is a broadspectrum carbamate herbicide. Asulam is a plant growth inhibitor which inhibits folate synthesis by suppression of dihydropteroate synthase (DHPS) in plants. The structure of asulam is represented as:

[0008]

[0009] Asulam is especially useful for post-emergence control of perennial grasses in crops such as sugarcane, soybean, cotton, etc. It provides effective control for a wide variety of herbicide-resistant and herbicide-tolerant weeds while reducing phyto toxicity in crops.

[0010] Oxyfluorfen is a diphenyl ether herbicide used for broad spectrum pre- and post- emergent control of annual broadleaf and grassy weeds in a variety of tree fruit, nut, vine, and field crops. It is a contact herbicide, and light is required for it to affect target plants. This herbicide inhibits the enzyme protoporphyrinogen oxidase (PPO), an essential enzyme involved in the biosynthesis of chlorophyll, the green pigment in plants. The structure of oxyfluorfen is represented as: Furthermore, herbicidal combinations known in the art usually have some disadvantages. They have none or insufficient herbicidal activity against specific unwanted plants / weeds, the spectrum of unwanted plants / weeds which can be controlled with the herbicides is not broad enough, the selectivity and compatibility of the herbicides with crops is too low, thereby causing unwanted damage and / or reduced yield of the crops, the initial herbicidal activity is not acceptable or not strong enough, and / or the herbicidal activity does not last long enough. For these reasons, there is a constant need to develop herbicidal combinations which overcome the aforementioned disadvantages. There also exists a need for an environmentally safe herbicidal combination that can selectively control unwanted plants / weeds, while leaving other plants and crops unharmed.

[0011] OBJECTIVES OF THE DISCLOSURE:

[0012] It is a primary objective of the present disclosure to provide a herbicidal combination for controlling or preventing unwanted plants / weeds in crops.

[0013] It is another objective of the present disclosure to provide a herbicidal combination for efficient weed control, weed suppression and weed eradication.

[0014] It is another objective of the present disclosure to provide a herbicidal combination possessing enhanced efficacy over the individual herbicides.

[0015] It is yet another objective of the present disclosure to provide a herbicidal combination comprising highly effective herbicidal actives for selective and non- selective weed control.

[0016] It is another objective of the present disclosure to provide a herbicidal combination comprising highly effective herbicidal actives for an efficient bum-down program.

[0017] It is yet another objective of the present disclosure to provide a herbicidal combination to control, suppress or prevent a wide spectrum of weeds comprising both dicotyledonous and monocotyledonous, broad-leaved, and grassy weeds. It is yet another objective of the present disclosure to provide a herbicidal combination which is safe to use, effective and can be applied pre-emergence, postemergence or at the time of sowing.

[0018] It is another objective of the present disclosure to provide a herbicidal combination achieving increased yield in the crops to which they are applied, by reducing the number of weeds in the crops.

[0019] Additionally, it is an objective of the present disclosure to provide a method of controlling resistant varieties of weeds with a herbicidal combination or a composition comprising such a combination.

[0020] SUMMARY OF THE DISCLOSURE:

[0021] In one aspect, the present disclosure provides a herbicidal combination comprising a carbamate herbicide and a diphenyl ether herbicide.

[0022] Another aspect of the present disclosure provides a herbicidal composition comprising a carbamate herbicide, a diphenyl ether herbicide, and at least one agrochemically acceptable excipient.

[0023] An aspect of the present disclosure also provides a process of preparing a herbicidal combination / compo sition comprising a carbamate herbicide and a diphenyl ether herbicide.

[0024] Yet another aspect provides use of a herbicidal combination comprising a carbamate herbicide and a diphenyl ether herbicide for effective control of weeds.

[0025] Another aspect of the present disclosure provides a method of controlling weeds comprising applying to a plant or a locus thereof, a herbicidal combination comprising a carbamate herbicide and a diphenyl ether herbicide. An aspect of the present disclosure also provides a kit-of-parts comprising a component of carbamate herbicide and another component of diphenyl ether herbicide. The said components may be mixed at the time of application as per the given set of instructions.

[0026] Additional features and advantages of the present disclosure will be apparent from the detailed description that follows, which illustrates by way of example, the most preferred features of the present disclosure which are not to be construed as limiting the scope of the disclosure described herein.

[0027] DETAILED DESCRIPTION OF THE DISCLOSURE:

[0028] The present disclosure now will be described hereinafter with reference to the accompanying examples, in which embodiments of the disclosure are shown. This description is not intended to be a detailed catalogue of all the different ways in which the disclosure may be implemented, or all the features that may be added to the instant disclosure. Thus, the disclosure contemplates that in some embodiments of the disclosure, any feature or combination of features set forth herein can be excluded or omitted. In addition, numerous variations and additions to the various embodiments suggested herein will be apparent to those skilled in the art in light of the instant disclosure, which do not depart from the instant disclosure. Hence, the following descriptions are intended to illustrate some particular embodiments of the disclosure, and not to exhaustively specify all permutations, combinations and variations thereof.

[0029] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the disclosure, suitable methods and materials are described herein. “About” or “approximately” as used herein is inclusive of the stated value and means within an acceptable range of deviation for the particular value as determined by one of ordinary skill in the art, considering the measurement in question and the error associated with measurement of the particular quantity (i.e., the limitations of the measurement system). For example, “about” can mean within one or more standard deviations, or within ±10 or ±5 of the stated value.

[0030] The use of the terms “a”, “an”, and “the” and similar referents (especially in the context of the following claims) are to be construed to cover both the singular and the plural, unless otherwise indicated herein or clearly contradicted by context. The terms first, second etc., as used herein are not meant to denote any particular ordering, but simply for convenience to denote a plurality of, for example, layers.

[0031] The terms “comprising”, “having”, “including”, and “containing” are to be construed as open-ended terms (i.e., meaning “including, but not limited to”) unless otherwise noted. The use of any and all examples, or exemplary language (e.g., “such as”), is intended merely to better illustrate the disclosure and does not pose a limitation on the scope of the disclosure unless otherwise claimed. No language in the specification should be construed as indicating any non-claimed element as essential to the practice of the disclosure as used herein.

[0032] While the disclosure has been described with reference to an exemplary embodiment, it will be understood by those skilled in the art that various changes may be made, and equivalents may be substituted for elements thereof without departing from the scope of the disclosure. In addition, many modifications may be made to adapt a particular situation or material to the teachings of the disclosure without departing from the essential scope thereof. Therefore, it is intended that the disclosure is not limited to the particular embodiment disclosed as the best mode contemplated for carrying out this disclosure, but that the disclosure will include all embodiments falling within the scope of the appended claims. The term “control” relates to a weed, includes control of the weed, as well as protecting a plant, a portion of the plant, or a plant seed from attack or invasion by said weed.

[0033] As used herein, the term “agrochemical” refers to all active substances which can be used in the agrochemical field, i.e., fungicides, bactericides, insecticides, acaricides, nematicides, molluscicides, rodenticides, repellents, plant growth regulators, herbicides and safeners, and plant nutrients.

[0034] Subsequently, the term “herbicide” encompasses both herbicides as well as plant growth regulators, as far as this does not otherwise emerge from the context. The term herbicide as used herein denotes a compound which controls or modifies the growth of undesired weeds / plants.

[0035] The term “herbicidally effective amount” indicates the quantity of such a compound or combination of such compounds which is capable of controlling or modifying effect on the growth of harmful plants / undesired vegetation / weeds. Controlling effects include all deviation from natural development, for example: killing, retardation, leaf bum, albinism, dwarfism, etc.

[0036] As used herein the term “plant” or “crop” refers to whole plants, plant organs (e.g., leaves, stems, twigs, roots, trunks, limbs, shoots, fruits etc.), plant cells, and plant seeds. This term also encompasses plant crops such as fruits. The term “plant” may further include the propagation material thereof, which may include all the generative parts of the plant such as seeds and vegetative plant material such as cuttings and tubers, which can be used for the multiplication of the plant. This includes seeds, tubers, spores, corms, bulbs, rhizomes, sprouts basal shoots, stolon, and buds and other parts of plants, including seedlings and young plants, which are to be transplanted after germination or after emergence from soil. As used herein, the term “plant propagation material” is understood to denote generative parts of a plant, such as seeds, vegetative material such as cuttings or tubers, roots, fruits, tubers, bulbs, rhizomes and parts of plants, germinated plants and young plants which are to be transplanted after germination or after emergence from the soil. These young plants may be protected before transplantation by a total or partial treatment by immersion.

[0037] As used herein, the term “seed” embraces seeds and plant propagules of all kinds including but not limited to true seeds, seed pieces, suckers, corms, bulbs, fruit, tubers, grains, cuttings, cut shoots and the like. In a preferred embodiment a seed is a true seed.

[0038] As used herein, the term “pre-emergence” refers to the time point before seedlings emerge from the ground. When any herbicide is applied at pre-emergence stage, it prevents establishment of the germinated weed seedlings. As used herein, the term “post-emergence” refers to the time point after seedlings emerge from the ground. When any herbicide is applied at post-emergence stage, it prevents growth of the germinated weed seedlings.

[0039] As used herein, the term “increased yield” of an agricultural plant means that the yield of a product of the respective plant is increased by a measurable amount over the yield of the same product of the plant produced under the same conditions, but without the application of the compositions described herein. According to the present disclosure, it is preferred that the crop yield be increased by at least 0.5%, preferably at least 2%, more preferably at least 5%, upon application of the combinations and compositions described herein.

[0040] The term “weed” as used herein refers to the plant whose growth is considered undesirable in a particular situation i.e., growth of a plant at a wrong place and includes pesticide resistant plants. In the broadest sense, the term “weed” refers to plants which grow in locations in which they are not desired. In other words, a “weed” is a plant in which in the context of a crop is undesirable due to competition for water, nutrients, sunlight, soil, etc. The term may also refer to crop plants which are undesirable at a location. As used herein, the terms “undesirable vegetation”, “harmful plants”, “unwanted plants”, “weeds” and “weed species”, as used herein, are synonyms.

[0041] Typically, the combinations / compositions of the present disclosure are applied to the targeted weed or to their locus or to the crop / plant. The term “locus” as used herein shall denote the vicinity of a desired crop in which weed control, typically selective weed control is desired. The locus includes the vicinity of desired crop plants wherein the weed infestation has either emerged or is yet to emerge. The term crop shall include a multitude of desired crop plants or an individual crop plant growing at a locus. The said locus could be a weed, an area adjacent to the weed, soil adapted to support growth of the weed, a root of the weed and / or foliage of the weed.

[0042] As used herein, the term “phytotoxicity” refers to any adverse effect or reaction on plant growth, physiology, or metabolism caused by any chemical substance, fertilizer, herbicide, heavy metal, etc.

[0043] As used herein, the term “L-glufosinate” or “Glufosinate-P” includes the L-isomer of Glufosinate, a salt and an ester thereof. The L-enantiomer of glufosinate acts by inhibition of glutamine synthetase thereby causing accumulation of toxic levels of ammonium ion and indirectly stopping photosynthesis. It is also known as phosphinothricin or (S)-2-amino-4-(hydroxy(methyl)phosphonoyl)butanoic acid. The term can generically refer to any form of L-glufosinate such as solvates, hydrates, esters, anhydrous form, polymorph forms, pseudo polymorph forms, amorphous form or mixture thereof, and sodium, potassium or ammonium salts. The salts of L-glufosinate such as monosodium salt, disodium salt, monopotassium salt, dipotassium salt, calcium salt, ammonium salt, -NH3(CH3)+ salt, - NH2(CH3)2+ salt, -NH(CH3)3+salt, -NH(CH3)2(C2H4OH)+ salt, and - NH2(CH3)(C2H4OH)+ salt are included in the definition. The agronomically acceptable salts include L-glufosinate-ammonium (Glufosinate-P-ammonium), L- glufosinate-sodium, and L-glufosinate -potassium. The term may also refer to an isomeric (racemic) mixture of L-glufosinate, D-glufosinate and salts thereof, wherein the content of L-glufosinate in the mixture is 70% or greater, preferably 80% or greater and more preferably 90% or greater. Typically, the ratio of L- glufosinate: D-glufosinate can be in the range from about 90: 10 to about 99.9:0.1, preferably from about 95:5 to about 99.9:0.1. As used herein, the term “L- glufosinate” may be used interchangeably with “glufosinate P”, “glufosinate-P”, “L glufosinate” or “LGF”.

[0044] As used throughout the disclosure, the carbamate herbicide, the diphenyl ether herbicide, and the organophosphorous herbicide include their salts, esters, ethers, polymorphs including solvates and hydrates. A salt includes salts that retain the biological effectiveness and properties of the active ingredient, and which are not biologically or otherwise undesirable, and include derivatives of the disclosed compounds in which the parent compound is modified by making inorganic and organic, non-toxic, acid or base addition salts thereof. The salts can be synthesized from the parent compound by conventional chemical methods.

[0045] According to an embodiment, the present disclosure provides a herbicidal combination for controlling weeds. In another embodiment, the present disclosure provides a herbicidal combination for controlling herbicide -resistant weeds and / or herbicide-tolerant weeds.

[0046] In another embodiment, the present disclosure provides a herbicidal combination comprising: at least one carbamate herbicide; and at least one diphenyl ether herbicide. In another embodiment, the mode of action of the carbamate herbicide is by inhibition of dihydropteroate synthase. In another embodiment, the mode of action of the diphenyl ether herbicide is by inhibition of protoporphyrinogen oxidase.

[0047] In another embodiment, the present disclosure provides a herbicidal combination comprising: a carbamate herbicide; and a diphenyl ether herbicide.

[0048] In another embodiment, the carbamate herbicide is selected from the group comprising asulam, barban, 1 -methylpropyl (3-chlorophenyl)carbamate (BCPC), carbasulam, carbetamide, carboxazole, 2-chloroethyl-N-3 -chlorophenylcarbamate (CEPC), chlorbufam, 2-chloro- 1-methylethyl (3-chlorophenyl)carbamate (CPPC), dichlormate, famoxacarb, fenasulam, propham, swep, terbucarb, salts, derivatives, or combinations thereof.

[0049] In a preferred embodiment, the carbamate herbicide is asulam.

[0050] In another embodiment, the present disclosure provides a herbicidal combination comprising: asulam; and at least one diphenyl ether herbicide.

[0051] In another embodiment, the diphenyl ether herbicide is selected from the group comprising oxyfluorfen, acifluorfen, aclonifen, bifenox, chlomethoxyfen, chlornitrofen, ethoxyfen, etnipromid, fluorodifen, fluoroglycofen, fluoronitrofen, fomesafen, fucaomi, furyloxyfen, halosafen, lactofen, nitrofen, nitrofluorfen, salts, derivatives, or combinations thereof.

[0052] In a preferred embodiment, the diphenyl ether herbicide is oxyfluorfen. In another embodiment, the present disclosure provides a herbicidal combination comprising: a carbamate herbicide comprising asulam; and a diphenyl ether herbicide comprising oxyfluorfen.

[0053] In a preferred embodiment, the present disclosure provides a herbicidal combination comprising asulam and oxyfluorfen.

[0054] According to an embodiment, the carbamate herbicide comprising asulam is present in a concentration from about 10 g / L to about 900 g / L, preferably from about 50 g / L to about 800 g / L, preferably from about 100 g / L to about 700 g / L, preferably from about 200 g / L to about 600 g / L, and preferably from about 300 g / L to about 500 g / L. In a preferred embodiment, asulam is present in a concentration of about 400 g / L.

[0055] According to an embodiment, the diphenyl ether herbicide comprising oxyfluorfen is present in a concentration from about 10 g / L to about 900 g / L, preferably from about 50 g / L to about 850 g / L, preferably from about 100 g / L to about 800 g / L, preferably from about 150 g / L to about 750 g / L, and preferably from about 200 g / L to about 700 g / L. In a preferred embodiment, oxyfluorfen is present in a concentration of about 240 g / L.

[0056] According to an embodiment, the organophosphorus herbicide comprising glyphosate is present in a concentration from about 10 g / L to about 900 g / L, preferably from about 100 g / L to about 850 g / L, preferably from about 200 g / L to about 800 g / L, preferably from about 300 g / L to about 750 g / L, and preferably from about 400 g / L to about 700 g / L. In a preferred embodiment, glyphosate is present in a concentration of about 620 g / L.

[0057] According to an embodiment, the organophosphorus herbicide comprising L- glufosinate is present in a concentration from about 1 g / L to about 500 g / L, preferably from about 10 g / L to about 450 g / L, preferably from about 20 g / L to about 400 g / L, preferably from about 30 g / L to about 350 g / L, and preferably from about 50 g / L to about 300 g / L. In a preferred embodiment, L-glufosinate is present in a concentration of about 200 g / L.

[0058] According to an embodiment, the present disclosure provides a herbicidal combination comprising a carbamate herbicide and a diphenyl ether herbicide, wherein the carbamate herbicide and the diphenyl ether herbicide are present in a weight ratio from about 1: 100 to about 100: 1, preferably from about 1:90 to about

[0059] 90: 1, preferably from about 1:80 to about 80: 1, preferably from about 1:70 to about

[0060] 70: 1, preferably from about 1:60 to about 60: 1, preferably from about 1:50 to about

[0061] 50: 1, preferably from about 1:40 to about 40: 1, preferably from about 1:30 to about

[0062] 30: 1, preferably from about 1:20 to about 20: 1, and more preferably from about 1: 10 to about 10: 1.

[0063] In a preferred embodiment, asulam and oxyfluorfen are present in a weight ratio of about 1:0.6.

[0064] According to an embodiment, the present disclosure provides a herbicidal combination comprising a diphenyl ether herbicide and an organophosphorus herbicide, wherein the diphenyl ether herbicide and the organophosphorus herbicide are present in a weight ratio from about 1:100 to about 100: 1, preferably from about 1:90 to about 90: 1, preferably from about 1:80 to about 80: 1, preferably from about 1:70 to about 70: 1, preferably from about 1:60 to about 60: 1, preferably from about 1:50 to about 50: 1, preferably from about 1:40 to about 40: 1, preferably from about 1:30 to about 30: 1, preferably from about 1:20 to about 20: 1, and more preferably from about 1: 10 to about 10: 1.

[0065] In a preferred embodiment, oxyfluorfen and glyphosate are present in a weight ratio of about 1:2.5. In a preferred embodiment, oxyfluorfen and L-glufosinate are present in a weight ratio of about 1:0.8. According to an embodiment, the present disclosure provides a herbicidal combination comprising a carbamate herbicide and an organophosphorus herbicide, wherein the carbamate herbicide and the organophosphorus herbicide are present in a weight ratio from about 1: 100 to about 100: 1, preferably from about 1:90 to about 90: 1, preferably from about 1:80 to about 80: 1, preferably from about 1:70 to about 70: 1, preferably from about 1:60 to about 60: 1, preferably from about 1:50 to about 50: 1, preferably from about 1:40 to about 40: 1, preferably from about 1:30 to about 30: 1, preferably from about 1:20 to about 20: 1, and more preferably from about 1: 10 to about 10: 1.

[0066] In a preferred embodiment, asulam and glyphosate are present in a weight ratio of about 1: 1.5. In a preferred embodiment, asulam and L-glufosinate are present in a weight ratio of about 1:0.5.

[0067] Unless otherwise indicated, the ratios disclosed throughout the specification are weight ratios.

[0068] In an embodiment, the herbicidal combination of the present disclosure may comprise an additional herbicide. In an embodiment, the herbicidal combination of the present disclosure optionally comprises an additional herbicide.

[0069] In an embodiment, the additional herbicide is selected from the group comprising aliphatic acid herbicides, amide herbicides, aromatic acid herbicides, benzofuran herbicides, benzonitrile herbicides, benzophenone herbicides, benzothiadiazinone herbicides, benzyl ether herbicides, botanical herbicides, carbamate herbicides, cyclohexanedione oxime herbicides, dinitroaniline herbicides, dinitrophenol herbicides, diphenyl ether herbicides, diphenyl heterocycle herbicides, dithiocarbamate herbicides, fumigant herbicides, halogenated alkanoic acid herbicides, imidazolinone herbicides, inorganic herbicides, isoxazole herbicides, isoxazolidinone herbicides, isoxazoline herbicides, N-phenyl heterocycle herbicides, N-phenylimide herbicides, N-phenyloxadiazolone herbicides, N- phenyltriazolinone herbicides, organochlorine herbicides, organophosphorous herbicides, oxirane herbicides, oxyacetamide herbicides, phenol herbicides, phenoxy herbicides, phenylcarboxylic acid herbicides, phenyl ether herbicides, phenylthiourea herbicides, pyrazole herbicides, pyridazine herbicides, pyridazinone herbicides, pyridine herbicides, pyrimidinediamine herbicides, pyrimidinyloxybenzylamine herbicides, quaternary ammonium herbicides, quinone herbicides, alpha- thio acetamide herbicides, thiocarbamate herbicides, thiocarbonate herbicides, triazine herbicides, triazinone herbicides, triazole herbicides, triazolone herbicides, triazolopyrimidine herbicides, triketone herbicides, uracil herbicides, urea herbicides, unclassified herbicides, or combinations thereof.

[0070] In an embodiment, the additional herbicide is selected from the group comprising organophosphorous herbicides. The organophosphorous herbicides are selected from the group comprising glycine derivative herbicides, phosphinic acid herbicides, phosphonate herbicides, phosphoramidate herbicides, phosphoro thiolate herbicides, or combinations thereof.

[0071] In an embodiment, the additional herbicide is selected from the group comprising glyphosate, L-glufosinate (glufosinate-P), glufosinate, huangcaoling, bilanafos, fosamine, amiprofos-methyl, amiprophos, butamifos, DMPA, shuangjiaancaolin, bensulide, or combinations thereof.

[0072] In a preferred embodiment, the additional herbicide is glyphosate. In a preferred embodiment, the additional herbicide is L-glufosinate (glufosinate-P).

[0073] In another embodiment, the present disclosure provides a herbicidal combination comprising: asulam; at least one diphenyl ether herbicide; and an additional herbicide. In another embodiment, the present disclosure provides a herbicidal combination comprising: a carbamate herbicide comprising asulam; a diphenyl ether herbicide comprising oxyfluorfen; and an additional herbicide comprising glyphosate.

[0074] In a preferred embodiment, the present disclosure provides a herbicidal combination comprising asulam, oxyfluorfen and glyphosate.

[0075] In another embodiment, the present disclosure provides a herbicidal combination comprising: a carbamate herbicide comprising asulam; a diphenyl ether herbicide comprising oxyfluorfen; and an additional herbicide comprising L-glufosinate.

[0076] In a preferred embodiment, the present disclosure provides a herbicidal combination comprising asulam, oxyfluorfen and L-glufosinate.

[0077] In another embodiment, the present disclosure provides a herbicidal composition comprising: a carbamate herbicide; a diphenyl ether herbicide; and at least one agrochemically acceptable excipient.

[0078] In another embodiment, the present disclosure provides a herbicidal composition comprising: asulam; oxyfluorfen; and at least one agrochemically acceptable excipient. In another embodiment, the present disclosure provides a herbicidal composition comprising: a carbamate herbicide; a diphenyl ether herbicide; an additional herbicide; and at least one agrochemically acceptable excipient.

[0079] In another embodiment, the present disclosure provides a herbicidal composition comprising: asulam; oxyfluorfen; glyphosate; and at least one agrochemically acceptable excipient.

[0080] In another embodiment, the present disclosure provides a herbicidal composition comprising: asulam; oxyfluorfen;

[0081] L-glufosinate; and at least one agrochemically acceptable excipient.

[0082] According to an embodiment of the present disclosure, the agrochemically acceptable excipients are selected from the group comprising emulsifier(s), colorant(s), thickener(s) / binder(s), antifreeze agent(s), antifoaming agent(s), antioxidant(s), solvent(s), preservative(s), glidant(s), anticaking agent(s), pH- regulating agent(s), buffering agent(s), formulation aid(s), disintegrant(s), or combinations thereof.

[0083] In another embodiment, in the herbicidal composition the carbamate herbicide is present from about 10% w / w to about 90% w / w, preferably from about 10% w / w to about 70% w / w, preferably from about 10% w / w to about 60% w / w, and more preferably from about 10% w / w to about 50% w / w of total weight of the composition.

[0084] In another embodiment, in the herbicidal composition the diphenyl ether herbicide is present from about 10% w / w to about 90% w / w, preferably from about 10% w / w to about 70% w / w, preferably from about 10% w / w to about 60% w / w, and more preferably from about 10% w / w to about 50% w / w of total weight of the composition.

[0085] In another embodiment, in the herbicidal composition the additional herbicide is present from about 10% w / w to about 90% w / w, preferably from about 10% w / w to about 70% w / w, preferably from about 10% w / w to about 60% w / w, and more preferably from about 10% w / w to about 50% w / w of total weight of the composition.

[0086] In another embodiment, in the herbicidal composition the agrochemically acceptable excipient is present from about 10% w / w to about 90% w / w of total weight of the composition.

[0087] In another embodiment, the present disclosure provides use of the herbicidal combination for controlling weeds, the combination comprising: a carbamate herbicide; and a diphenyl ether herbicide.

[0088] In another embodiment, the present disclosure provides use of the herbicidal combination for controlling weeds, the combination comprising: asulam; and oxyfluorfen.

[0089] In another embodiment, the present disclosure provides use of the herbicidal combination for controlling weeds, the combination comprising: a carbamate herbicide; a diphenyl ether herbicide; and an additional herbicide.

[0090] In another embodiment, the present disclosure provides use of the herbicidal combination for controlling weeds, the combination comprising: asulam; oxyfluorfen; and glyphosate.

[0091] In another embodiment, the present disclosure provides use of the herbicidal combination for controlling weeds, the combination comprising: asulam; oxyfluorfen; and

[0092] L-glufosinate.

[0093] In another embodiment, the present disclosure provides use of the herbicidal combination for controlling weeds. In an embodiment, the present disclosure provides use of a herbicidal combination, for controlling herbicide-resistant and / or herbicide-tolerant weeds. In an embodiment, the present disclosure provides use of a herbicidal combination, for improving yield of the desired crop.

[0094] In another embodiment, the present disclosure provides a method for controlling weeds, wherein the method comprises applying to a plant or a locus thereof an effective amount of a herbicidal combination comprising: a carbamate herbicide; and a diphenyl ether herbicide.

[0095] In another embodiment, the present disclosure provides a method for controlling weeds, wherein the method comprises applying to a plant or a locus thereof an effective amount of a herbicidal combination comprising: asulam; and oxyfluorfen.

[0096] In another embodiment, the present disclosure provides a method for controlling weeds, wherein the method comprises applying to a plant or a locus thereof an effective amount of a herbicidal combination comprising: a carbamate herbicide; a diphenyl ether herbicide; and an additional herbicide.

[0097] In another embodiment, the present disclosure provides a method for controlling weeds, wherein the method comprises applying to a plant or a locus thereof an effective amount of a herbicidal combination comprising: asulam; oxyfluorfen; and glyphosate.

[0098] In another embodiment, the present disclosure provides a method for controlling weeds, wherein the method comprises applying to a plant or a locus thereof an effective amount of a herbicidal combination comprising: asulam; oxyfluorfen; and

[0099] L-glufosinate.

[0100] In another embodiment, the present disclosure provides a method for controlling weeds by application of the herbicidal combination. In another embodiment, the present disclosure provides a method for controlling herbicide -resistant and / or herbicide-tolerant weeds by application of the herbicidal combination.

[0101] In another embodiment, the present disclosure provides a method for controlling weeds by application of an effective amount of the herbicidal combination to a plant, or a plant propagation material, or a locus thereof. The selection of the effective amount depends on the density of weed infestation, weather patterns, crop health, etc. In an embodiment, the present disclosure provides a method for controlling weeds, wherein the weeds are treated by applying concurrently or subsequently or sequentially the herbicidal combination.

[0102] According to an embodiment, the herbicidal combination / compo sition is present either in the form of a tank mix or a pre-formulated (pre-mix) composition.

[0103] In another embodiment, the herbicidal combination comprises a carbamate herbicide applied at an application rate from about 1 g a.i. / ha to about 2000 g a.i. / ha, preferably from about 100 g a.i. / ha to about 2000 g a.i. / ha, preferably from about 500 g a.i. / ha to about 2000 g a.i. / ha, preferably from about 750 g a.i. / ha to about 2000 g a.i. / ha, preferably from about 1000 g a.i. / ha to about 2000 g a.i. / ha, and more preferably from about 1100 g a.i. / ha to about 1900 g a.i. / ha.

[0104] In a preferred embodiment, the herbicidal combination comprises asulam applied at an application rate of about 1800 g a.i. / ha. In a preferred embodiment, the herbicidal combination comprises asulam applied at an application rate of about 1400 g a.i. / ha.

[0105] In another embodiment, the herbicidal combination comprises a diphenyl ether herbicide applied at an application rate from about 1 g a.i. / ha to about 2000 g a.i. / ha, preferably from about 1 g a.i. / ha to about 1500 g a.i. / ha, preferably from about 10 g a.i. / ha to about 1000 g a.i. / ha, preferably from about 10 g a.i. / ha to about 900 g a.i. / ha, preferably from about 10 g a.i. / ha to about 800 g a.i. / ha, preferably from about 10 g a.i. / ha to about 700 g a.i. / ha, and more preferably from about 10 g a.i. / ha to about 500 g a.i. / ha.

[0106] In a preferred embodiment, the herbicidal combination comprises oxyfluorfen applied at an application rate of about 480 g a.i. / ha. In a preferred embodiment, the herbicidal combination comprises oxyfluorfen applied at an application rate of about 240 g a.i. / ha.

[0107] In another embodiment, the herbicidal combination comprises an organophosphorus herbicide applied at an application rate from about 1 g a.i. / ha to about 2000 g a.i. / ha, preferably from about 1 g a.i. / ha to about 1900 g a.i. / ha, and more preferably from about 1 g a.i. / ha to about 1800 g a.i. / ha.

[0108] In a preferred embodiment, glyphosate is applied at an application rate of about 1790 g a.i. / ha. In a preferred embodiment, L-glufosinate is applied at an application rate of about 200 g a.i. / ha.

[0109] In another embodiment, the combination of the present disclosure is used to control weeds in various agricultural crops. Non-limiting examples of weeds controlled by the combination of the present disclosure comprise Spermacoce densiflora, Digitaria insularis, Commelina benghalensis, Bidens subalternans, Euphorbia hirta, Raphanus raphanistrum, Raphanus sativus, Sinapis arvensis, Capsella bursa- pastoris, Brassica juncea, Brassica campestris, Descurainia pinnata, Rorippa islandica, Rorippa sylvestris, Thlaspi arvense, Myagrum rugosum, Lepidium virginicum, Coronopus didymus, Dinebra retroflexa, Cynodon dactylon, Echinochloa colonum, Echinochloa crusgalli, Setaria viridis, Setaria faberi, Setaria glauca, Setaria ilosa ate, Digitaria ciliaris, Digitaria sanguinalis, Digitaria horizontalis, Eleusine indica, Poa annua, Alospecurus aequalis, Alopecurus myosuroides, Avena fatua, Sorghum halepense, Sorghum vulgare, Agropyron repens, Eolium multiflorum, Eolium perenne, Eolium rigidum, Bromus secalinus, Bromus tectorum, Elordeum jubatum, Aegilops cylindrica, Phalaris arundinacea, Phalaris minor, Apera spicaventi, Panicum dichotomiflorum, Panicum texanum, Panicum maximum, Brachiaria reptains Brachiaria platyphylla, Brachiaria ruziziensis, Brachiaria plantaginea, Brachiaria decumbens, Brachiaria brizantha, Brachiaria humidicola, Brachiaria mutica, Cenchrus echinatus, Cenchrus pauciflorus, Eriochloa villosa, Pennisetum setosum, Chloris gayana, Chloris barbata, Eragrostis ilosa, Rhynchelitrum repens, Dactyloctenium aegyptium, Ischaemum rugosum, Oryza sativa, Paspalum notatum, Paspalum maritimum, Pennisetum clandestinum, Pennisetum setosum, Rotboellia cochinchinensis, Conzya species, Avena Sativa, Glycine max, Phaseolus vulgaris, or combinations thereof.

[0110] In a preferred embodiment, the weeds are selected from Spermacoce densiflora, Digitaria insularis, Commelina benghalensis, Bidens subalternans, Euphorbia hirta, Amaranthus hybridus, Eleusine indica, or combinations thereof.

[0111] In another embodiment, the combination of the present disclosure is used to control weeds in various agricultural crops.

[0112] According to an embodiment, the present disclosure provides a method for controlling weeds in crops comprising rice, wheat, barley, rye, oat, sorghum, cotton, soybean, peanut, buckwheat, beet, rapeseed, sunflower, durum wheat, fall wheat, field corn, winter barley, cotton, fall barley, fallow, spring wheat, triticale, winter wheat, sugar cane, tobacco, etc.; vegetables; solanaceous vegetables such as eggplant, tomato, pimento, popper, potato, etc., cucurbit vegetables such as cucumber, pumpkin, zucchini, water melon, melon, squash, etc., cruciferous vegetables such as radish, white turnip, horseradish, kohlrabi, Chinese cabbage, cabbage, leaf mustard, broccoli, cauliflower, etc., asteraceous vegetables such as burdock, crown daisy, artichoke, lettuce, etc., liliaceous vegetables such as green onion, onion, garlic, and asparagus, ammiaceous vegetables such as carrot, parsley, celery, parsnip, etc., chenopodiaceous vegetables such as spinach, Swiss chard, etc., lamiaceous vegetables such as Perilla frutescens, mint, basil, etc. strawberry, sweet potato, Dioscorea japonica, colocasia, etc., flowers, foliage plants, turf grasses, fruits: pome fruits such apple, pear, quince, etc. stone fleshy fruits such as peach, plum, nectarine, Prunus mume, cherry fruit, apricot, prune, etc., citrus fruits such as orange, lemon, rime, grapefruit, etc., nuts such as chestnuts, walnuts, hazelnuts, almond, pistachio, cashew nuts, macadamia nuts, etc. berries such as blueberry, cranberry, blackberry, raspberry, etc., grape, kaki fruit, olive, plum, banana, coffee, date palm, coconuts, etc., trees otter than fruit trees; tea, mulberry, flowering plant, trees such as ash, birch, dogwood, Eucalyptus, Ginkgo biloba, lilac, maple, Quercus, poplar, Judas tree, liquidambar formosana, plane tree, zelkova. Japanese arborvitae, fir wood, hemlock, juniper, Pinus, Picea, and Taxus cuspidate, or combinations thereof.

[0113] According to an embodiment of the present disclosure, the herbicidal combination comprising asulam, oxyfluorfen and glyphosate / L-glufosinate provides from about 48% to about 100% control of the weeds.

[0114] According to an embodiment of the present disclosure, the herbicidal combination is usually applied to the unwanted plants / weeds by spraying on the leaves. Here, the application can be carried out using, for example, water as carrier by customary spraying techniques. In an embodiment, the application of the herbicidal combination may be done before, during and / or after, preferably before and / or after, the sowing of the crops. In an embodiment, the application of the herbicidal combination may be done on fallow field. In a preferred embodiment, the application of the herbicidal combination may be done to control the growth of weeds at the pre-emergence stage or the post-emergence stage. In a preferred embodiment, the application of the herbicidal combination may be done to control the growth of weeds close to the sowing stage of the crop.

[0115] According to an embodiment of the present disclosure, the herbicidal combination may be applied pre-or post-emergence of weeds, or together with the plant, or plant propagation material, or locus of a plant thereof. It is also possible to apply the herbicidal combination to a plant, or a plant propagation material, or a locus thereof or pre-treating a crop plant with the herbicidal combination.

[0116] In another embodiment, the herbicidal combination of the present disclosure may be applied in combination with agrochemical components such as fertilizers, macronutrients, micronutrients, biologic als, bio stimulants, plant extracts, synergists, or combinations thereof. In an embodiment, the macronutrients or a micronutrient is selected from the group comprising nitrogen, phosphorus, potassium, calcium, sulfur, magnesium, iron, zinc, copper, boron, manganese, chlorine, molybdenum, nickel, or combinations thereof.

[0117] In another embodiment, the additional herbicide may be admixed with an adjuvant or a bio-stimulant or a fertilizer compound such that said components may be tank mixed before spraying.

[0118] According to an embodiment, the herbicidal combination is applied from a predosage device, a knapsack sprayer, a spray tank, a spray plane, or an irrigation system, or a drone, or an spot spray system. Typically, the herbicidal combination is made up with water, buffer, and / or further auxiliaries to the desired application concentration and the ready-to-use spray liquor of the herbicidal combination is thus obtained.

[0119] In another embodiment, the herbicidal combination may be used for foliar application, application to a ground, or to the soil, or to a plant, or a locus or a plant propagation material, or combinations thereof.

[0120] In another embodiment, the herbicidal combination can be used in agricultural lands such as fields, paddy fields, lawns and orchards or in non-agricultural lands, fallow fields, or for the purpose of chemical fallow application.

[0121] According to an embodiment, the present disclosure provides a process for preparing a herbicidal combination / compo sition comprising: a carbamate herbicide; a diphenyl ether herbicide; and at least one agrochemically acceptable excipient thereof; wherein the process comprises mixing the carbamate herbicide, the diphenyl ether acid herbicide and at least one agrochemically acceptable excipient homogenously to form the herbicidal combination / composition.

[0122] According to an embodiment, the present disclosure provides a process for preparing a herbicidal combination / composition comprising: a carbamate herbicide; a diphenyl ether herbicide; an additional herbicide; and at least one agrochemically acceptable excipient thereof; wherein the process comprises mixing the carbamate herbicide, the diphenyl ether acid herbicide, the additional herbicide and at least one agrochemically acceptable excipient homogenously to form the herbicidal combination / composition.

[0123] According to an embodiment, the various components of the herbicidal combination may be used individually or already partially or completely mixed with one or more to prepare the herbicidal combination. It is also possible for the components to be separately packaged and used as a component in a kit of parts. In one embodiment, the kits may include one or more of the components that are used to prepare the herbicidal combination. For examples, the kits may include active ingredients and / or at least one agrochemically acceptable excipient. One or more of the components may already be combined together or pre-formulated.

[0124] One or more of the components may already be combined together or preformulated. In those embodiments where more than two components are provided in a kit, the components may already be combined and as such are packaged in a single container such as a vial, bottle, can, pouch, bag and / or canister. In other embodiments, two or more components of a kit may be packaged separate from one another, i.e., they are not pre-formulated. As such, a kit may include one or more separate containers such as vials, cans, bottles, pouches, bags and / or canisters, each container containing a separate component of the herbicidal combination. According to an embodiment, the kit of parts comprises: at least one carbamate herbicide; at least one diphenyl ether herbicide; and optionally further comprises: instructions for use.

[0125] According to an embodiment, the kit of parts comprises: at least one carbamate herbicide; at least one diphenyl ether herbicide; an additional herbicide; and optionally further comprises: instructions for use.

[0126] In an embodiment, the herbicidal combination comprising a carbamate herbicide, and a diphenyl ether herbicide may provide synergistic control for weeds at pre- emergent and / or at post-emergent stage. In another embodiment, the herbicidal combination is synergistic and effective in improving yield of desired crop by controlling weeds. The herbicidal combination also provides increase in crop yield and crop quality.

[0127] In view of the above, it will be seen that several advantages of the disclosure are achieved, and other advantageous results are attained. Although the present disclosure has been disclosed in full, it will be understood that numerous additional modifications and variations could be made thereto without departing from the scope of the disclosure.

[0128] The disclosure may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive. EXAMPLES:

[0129] The following active ingredient compounds were used in the present invention to prepare combinations / compositions of asulam with oxyfluorfen. Example 1: Efficacy of Asulam and Oxyfluorfen on Spermacoce densiflora

[0130] The herbicidal combination comprising asulam and oxyfluorfen was evaluated to assess the efficacy of the combination for percentage control of Spermacoce densiflora on 21, 28 and 35 days after application (DAA). No phytotoxicity was observed on the crops. The results have been tabulated in Table 1. Table 1

[0131] It was observed that the herbicidal combination comprising asulam and oxyfluorfen showed enhanced control for Spermacoce densiflora. Example 2: Efficacy of Asulam and Oxyfluorfen on Digitaria insularis

[0132] The herbicidal combination comprising asulam and oxyfluorfen was evaluated to assess the efficacy of the combination for percentage control of Digitaria insularis on 28 and 35 days after application (DAA). No phytotoxicity was observed on the crops. The results have been tabulated in Table 2. Table 2

[0133] It was observed that the herbicidal combination comprising asulam and oxyfluorfen showed enhanced control for Digitaria insularis.

[0134] The following active ingredient compounds were used in the present invention to prepare combinations / compositions of asulam with oxyfluorfen.

[0135] Example 3: Efficacy of Asulam and Oxyfluorfen on Commelina benghalensis The herbicidal combination comprising asulam and oxyfluorfen was evaluated to assess the efficacy of the combination for percentage control of Commelina benghalensis on 21 and 28 days after application (DAA). No phytotoxicity was observed on the crops. The results have been tabulated in Table 3.

[0136] Table 3

[0137] It was observed that the herbicidal combination comprising asulam and oxyfluorfen showed enhanced control for Commelina benghalensis.

[0138] Example 4: Efficacy of Asulam and Oxyfluorfen on Bidens subalternans

[0139] The herbicidal combination comprising asulam and oxyfluorfen was evaluated to assess the efficacy of the combination for percentage control of Bidens subalternans on 14 and 21 days after application (DAA). No phytotoxicity was observed on the crops. The results have been tabulated in Table 4.

[0140] Table 4

[0141] It was observed that the herbicidal combination comprising asulam and oxyfluorfen showed enhanced control for Bidens subalternans.

[0142] Example 5: Efficacy of Asulam and Oxyfluorfen on Euphorbia hirta

[0143] The herbicidal combination comprising asulam and oxyfluorfen was evaluated to assess the efficacy of the combination for percentage control of Euphorbia hirta on 14, 21, 28 and 35 days after application (DAA). No phytotoxicity was observed on the crops. The results have been tabulated in Table 5. Table 5

[0144] It was observed that the herbicidal combination comprising asulam and oxyfluorfen showed enhanced control for Euphorbia hirta.

[0145] 5

[0146] The following active ingredient compounds were used in the present invention to prepare combinations / compositions of asulam and oxyfluorfen and L-glufosinate.

[0147] Example 6: Efficacy of Asulam + Oxyfluorfen + Glyphosate and Asulam + 10 Oxyfluorfen + L-glufosinate on Amaranthus hybridus

[0148] The herbicidal combination comprising asulam and oxyfluorfen and glyphosate / L- glufosinate was evaluated to assess the efficacy of the combination for percentage control of Amaranthus hybridus on 14 and 21 days after application (DA- A). No phytotoxicity was observed on the crops. The results have been tabulated in Table 15 6. Table 6

[0149] It was observed that the herbicidal combination comprising asulam and oxyfluorfen and glyphosate / L-glufosinate showed enhanced efficacy in control of Amaranthus hybridus as compared to asulam and oxyfluorfen.

[0150] Example 7: Efficacy of Asulam + Oxyfluorfen + Glyphosate and Asulam + Oxyfluorfen + L-glufosinate on Digitaria insularis

[0151] The herbicidal combination comprising asulam and oxyfluorfen and glyphosate / L- glufosinate was evaluated to assess the efficacy of the combination for percentage control of Digitaria insularis on 14 and 21 days after application (DA-A). No phytotoxicity was observed on the crops. The results have been tabulated in Table 7.

[0152] Table 7

[0153] It was observed that the herbicidal combination comprising asulam and oxyfluorfen and glyphosate / L-glufosinate showed enhanced efficacy in control of Digitaria insularis as compared to asulam and oxyfluorfen.

[0154] Example 8: Efficacy of Asulam + Oxyfluorfen + Glyphosate and Asulam + Oxyfluorfen + L-glufosinate on Eleusine indica

[0155] The herbicidal combination comprising asulam and oxyfluorfen and glyphosate / L- glufosinate was evaluated to assess the efficacy of the combination for percentage control of Eleusine indica on 14, 21 and 28 days after application (DA-A). No phytotoxicity was observed on the crops. The results have been tabulated in Table 8.

[0156] Table 8 It was observed that the herbicidal combination comprising asulam and oxyfluorfen and glyphosate / L-glufosinate showed enhanced efficacy in control of Eleusine indica as compared to asulam and oxyfluorfen. Example 9: Efficacy of Asulam + Oxyfluorfen + Glyphosate and Asulam + Oxyfluorfen + L-glufosinate on Spermacoce densiflora

[0157] The herbicidal combination comprising asulam and oxyfluorfen and glyphosate / L- glufosinate was evaluated to assess the efficacy of the combination for percentage control of Spermacoce densiflora on 14, 21 and 28 days after application (DA-A). No phytotoxicity was observed on the crops. The results have been tabulated in Table 9.

[0158] Table 9

[0159] It was observed that the herbicidal combination comprising asulam and oxyfluorfen and glyphosate / L-glufosinate showed enhanced efficacy in control of Spermacoce densiflora as compared to asulam and oxyfluorfen.

Claims

CLAIMS:

1. A herbicidal combination comprising: asulam; and at least one diphenyl ether herbicide.

2. The combination as claimed in claim 1, wherein the diphenyl ether herbicide is selected from the group comprising oxyfluorfen, acifluorfen, aclonifen, bifenox, chlomethoxyfen, chlornitrofen, ethoxyfen, etnipromid, fluorodifen, fluoroglycofen, fluoronitrofen, fomesafen, fucaomi, furyloxyfen, halosafen, lactofen, nitrofen, nitrofluorfen, salts, derivatives, or combinations thereof.

3. The combination as claimed in claim 2, wherein the diphenyl ether herbicide is oxyfluorfen.

4. The combination as claimed in claim 3, wherein asulam and oxyfluorfen are present in a weight ratio from about 1:25 to about 25: 1.

5. The combination as claimed in claim 1, wherein the combination comprises at least one additional herbicide selected from the group comprising glyphosate, L-glufosinate, glufosinate, or combinations thereof.

6. The combination as claimed in claim 5, wherein asulam and glyphosate or L- glufosinate are present in a weight ratio from about 1:25 to about 25: 1.

7. The combination as claimed in claim 5, wherein oxyfluorfen and glyphosate or L-glufosinate are present in a weight ratio from about 1:25 to about 25: 1.

8. Use of the herbicidal combination as claimed in claim 1, for controlling weeds by concurrent or subsequent or sequential application.

9. A method for controlling weeds, wherein the method comprises applying to a plant or a locus thereof, an effective amount of a herbicidal combination comprising: asulam; and at least one diphenyl ether herbicide.

10. The method as claimed in claim 9, wherein the combination comprises at least one additional herbicide selected from the group comprising glyphosate, L- glufosinate, glufosinate, or combinations thereof.

11. The method as claimed in claim 9, wherein the method comprises: asulam applied at an application rate from about 1000 g a.i. / ha to about 2000 g a.i. / ha; oxyfluorfen applied at an application rate from about 1 g a.i. / ha to about 800 g a.i. / ha; glyphosate applied at an application rate from about 1 g a.i. / ha to about 1800 g a.i. / ha; andL-glufosinate applied at an application rate from about 1 g a.i. / ha to about 1800 g a.i. / ha.

12. The method as claimed in claim 9, wherein the weeds are selected from Spermacoce densiflora, Digitaria insularis, Commelina benghalensis, Bidens subalternans, Euphorbia hirta, Amaranthus hybridus, Eleusine indica, or combinations thereof.

13. The method as claimed in claim 9, wherein the combination provides from about 48% to about 100% control of the weeds.

14. A herbicidal composition comprising: asulam; at least one diphenyl ether herbicide; andat least one agrochemically acceptable excipient.

15. The composition as claimed in claim 14, wherein the composition comprises at least one additional herbicide selected from the group comprising glyphosate, L-glufosinate, glufosinate, or combinations thereof.

Images