Pyrazine macrolide compound and use thereof
By developing pyrazine macrolide compounds, the problems of drug resistance and safety of macrolide antibiotics have been solved, providing an effective treatment option for Gram-positive bacteria, Gram-negative bacteria and mycoplasma.
WO2026086945A1PCT designated stage Publication Date: 2026-04-30EVOPOINT BIOSCIENCES CO LTD
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Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- EVOPOINT BIOSCIENCES CO LTD
- Filing Date
- 2025-10-24
- Publication Date
- 2026-04-30
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Figure PCTCN2025129998-FTAPPB-I100001 
Figure PCTCN2025129998-FTAPPB-I100002 
Figure PCTCN2025129998-FTAPPB-I100003
Abstract
The present invention relates to a pyrazine macrolide compound and the use thereof. Specifically disclosed is a compound as represented by formula I or a pharmaceutically acceptable salt thereof. The compound of the present invention exhibits activity against bacteria, mycoplasmas, or chlamydias, and is useful for preventing and / or treating diseases caused by bacteria, mycoplasmas, or chlamydias. Further, the compound of the present application can achieve an antibacterial activity comparable to or better than that of azithromycin or solithromycin at a lower dosage. Furthermore, the compound of the present application achieves a superior antibacterial effect on Gram-positive bacteria. Still furthermore, the compound of the present application exhibits a better inhibitory activity against mycoplasmas and a lower hepatotoxicity.
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