Biocompatible, electrically conducting hydrogels, preparation and use thereof

A biocompatible, electrically conducting, and optically transparent hydrogel is created via 3D printing, addressing the limitations of existing hydrogels by providing a suitable scaffold for cell growth and differentiation, with improved conductivity and mechanical properties, suitable for bioprinting and stem cell engineering.

WO2026087490A1PCT designated stage Publication Date: 2026-04-30TECH UNIV DELFT
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Patent Information

Application Number
PCT/EP2025/080309
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-10-21
Filing Date
2025-10-21
Publication Date
2026-04-30

AI Technical Summary

Technical Problem

Existing hydrogels lack the required conductive properties combined with biocompatibility and transparency necessary for use as 3D platforms to monitor and guide stem-cell-to-functional cell differentiation using electrical cues, and are often prepared under biologically harmful conditions.

Method used

A biocompatible, electrically conducting, and optically transparent hydrogel is developed via 3D printing, comprising a conducting polymer, extracellular material, and hydrogel forming polymer, with the addition of multivalent cations, and optionally incorporating biological cells, to create a favorable environment for cell growth and differentiation.

Benefits of technology

The hydrogel provides a suitable scaffold for cell growth, supports functional cell network development, and is suitable for bioprinting, soft electronics, and stem cell engineering, with good conductivity, mechanical properties, and cell viability.

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Abstract

The invention relates to biocompatible electrically conducting and preferably optically transparent hydrogels, to a 3D printing method of forming such biocompatible electrically conducting and / or optically transparent hydrogels, to a method for developing functional cell networks from human induced pluripotent stem cells, to a 3D bioelectric platform comprising said 3D-printed biocompatible electrically conducting and / or optically transparent hydrogels and a method of creating the same, and to the use of said hydrogels.
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Citation Information

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