Liquid nicotine formulation for use in an aerosol-generating system

Abstract

A liquid nicotine formulation for use in an aerosol-generating system, the liquid nicotine formulation comprising: nicotine; a liquid carrier; one or more monocarboxylic acids, one or more high-intensity sweeteners; and one or more cooling agents, wherein a ratio of the weight percent total cooling agent content to the weight percent total high-intensity sweetener content of the liquid nicotine formulation is between about 30:1 and about 60:1.

Description

[0001] P / 91070.W002

[0002] - 1 -

[0003] LIQUID NICOTINE FORMULATION FOR USE IN AN AEROSOL-GENERATING SYSTEM

[0004] The invention relates to a liquid nicotine formulation for use in an aerosol-generating system. The invention also relates to a cartridge for an aerosol-generating system comprising the liquid nicotine formulation and to an aerosol-generating system comprising the cartridge.

[0005] Aerosol-generating systems for delivering nicotine to a user that comprise an atomiser configured to generate an inhalable aerosol from a liquid nicotine formulation are known. Some known aerosol-generating systems comprise a thermal atomiser that is configured to heat the liquid nicotine formulation to generate an aerosol. Other known aerosol-generating systems comprise a non-thermal atomiser that is configured to generate an aerosol from the liquid nicotine formulation using, for example, impinging jet, ultrasonic or vibrating mesh technologies.

[0006] Handheld electrically operated aerosol-generating systems comprising a cartridge comprising a liquid storage portion comprising a supply of liquid nicotine formulation and an electrically operated heater configured to heat the liquid nicotine formulation to generate an aerosol, and an aerosol-generating device comprising control electronics and a power source for supplying power to the electrically operated heater, are known.

[0007] The heater typically comprises a coil of electrically conductive wire that is wound around an elongate wick, which transports liquid nicotine formulation from the liquid storage portion of the cartridge to the coil of wire. In use, an electric current may be passed through the coil of wire to heat the liquid nicotine formulation to generate an aerosol.

[0008] However, in other known handheld electrically operated aerosol-generating systems the heater comprises a fluid permeable heating element comprising an electrically conductive mesh that is in contact with a transport material, which conveys liquid nicotine formulation to the electrically conductive mesh. In use, an electric current may be passed through the electrically conductive mesh to heat the liquid nicotine formulation to generate an aerosol.

[0009] A cartridge comprising a supply of liquid nicotine formulation and an atomiser configured to generate an aerosol from the liquid nicotine formulation is sometimes referred to as a “cartomiser”. The liquid storage portion of the cartridge may comprise a retention material for holding the liquid nicotine formulation. The cartridge typically also comprises a mouthpiece portion that a user draws on, in use, in order to inhale the generated aerosol.

[0010] Liquid nicotine formulations for use in aerosol-generating systems typically comprise a liquid carrier comprising one or more solvents, such as glycerine, propylene glycol and water, and optionally one or more flavourants. It is also known to include acids in liquid nicotine formulations for use in aerosol-generating systems. P / 91070.W002

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[0012] I nclusion of an acid in a liquid nicotine formulation for use in an aerosol-generating system may advantageously enable generation of an inhalable aerosol having improved sensory properties. Inclusion of an acid may advantageously enable generation of an inhalable aerosol providing improved nicotine satisfaction to a user.

[0013] It would be desirable to provide a liquid nicotine formulation for use in an aerosolgenerating system that, in use, can provide an aerosol with improved user satisfaction and a balanced sensory experience. It would be particularly desirable to provide a liquid nicotine formulation for use in an aerosol-generating system that, in use, can provide an aerosol with improved user satisfaction and a balanced sensory experience without adversely impacting other properties of the aerosol, such as particle or droplet size and nicotine delivery.

[0014] According to a first aspect of the invention there is provided a liquid nicotine formulation for use in an aerosol-generating system, the liquid nicotine formulation comprising: nicotine; a liquid carrier; one or more monocarboxylic acids; one or more high-intensity sweeteners; and one or more cooling agents.

[0015] According to the first aspect of the invention there is provided a liquid nicotine formulation for use in an aerosol-generating system, the liquid nicotine formulation comprising: nicotine; a liquid carrier comprising propylene glycol and glycerine; one or more monocarboxylic acids; one or more high-intensity sweeteners; and one or more cooling agents.

[0016] According to the first aspect of the invention there is provided liquid nicotine formulation for use in an aerosol-generating system, the liquid nicotine formulation comprising: nicotine; a liquid carrier; one or more monocarboxylic acids, one or more high-intensity sweeteners; and one or more cooling agents, wherein a ratio of the weight percent total cooling agent content to the weight percent total high-intensity sweetener content of the liquid nicotine formulation is between about 30: 1 and about 60: 1.

[0017] According to the first aspect of the invention there is provided a liquid nicotine formulation for use in an aerosol-generating system, the liquid nicotine formulation comprising: nicotine; a liquid carrier comprising propylene glycol and glycerine; one or more carboxylic acids selected from benzoic acid and lactic acid; one or more high intensity sweeteners selected from advantame, aspartame, acesulfame potassium, cyclamates, glycyrrhizin, mogrosides, neotame, saccharin, steviol glycosides, and sucralose; and one or more cooling agents selected from: isomenthone, isomenthyl acetate, isopulegone, L-carvone, menthol, menthone, menthyl acetate, menthyl lactate, menthyl isovalerate, WS-3; WS-5; WS-12, and WS-23.

[0018] According to the first aspect of the invention there is provided a liquid nicotine formulation for use in an aerosol-generating system, the liquid nicotine formulation comprising: nicotine; a liquid carrier comprising propylene glycol and glycerine; one or more carboxylic acids selected from benzoic acid and lactic acid; one or more high intensity sweeteners selected from P / 91070.W002

[0019] - 3 - advantame, aspartame, acesulfame potassium, cyclamates, glycyrrhizin, mogrosides, neotame, saccharin, steviol glycosides, and sucralose; and a first cooling agent selected from: isomenthone, isomenthyl acetate, isopulegone, L-carvone, menthol, menthone, menthyl acetate, menthyl lactate, and menthyl isovalerate and a second cooling agent selected from WS-3; WS-5; WS-12, and WS-23.

[0020] According to the first aspect of the invention there is provided a liquid nicotine formulation for use in an aerosol-generating system, the liquid nicotine formulation comprising: nicotine; a liquid carrier comprising propylene glycol and glycerine; benzoic acid; neotame; and menthol and WS-23.

[0021] According to the first aspect of the invention there is provided a liquid nicotine formulation for use in an aerosol-generating system, the liquid nicotine formulation comprising: nicotine; propylene glycol and glycerine; benzoic acid; neotame; menthol and WS-23; and one or more non-cooling flavourants.

[0022] According to the first aspect of the invention there is provided a liquid nicotine formulation for use in an aerosol-generating system, the liquid nicotine formulation comprising: nicotine in an amount of between about 0.6 percent by weight and about 4 percent by weight; propylene glycol in an amount of between about 45 percent by weight and about 55 percent by weight; benzoic acid in an amount of between 0.5 percent by weight and about 3 percent by weight; glycerine in an amount of between about 35 percent by weight and about 45 percent by weight; neotame in an amount of between about 0.05 percent by weight and about 0.4 percent by weight; menthol in an amount of between about 0.75 percent by weight and about 2.5 percent by weight; WS-23 in an amount of between about 0.45 percent by weight and about 1 percent by weight; and optionally one or more non-cooling flavourants in an amount of between about 3 percent by weight and about 12 percent by weight.

[0023] According to a second aspect of the invention there is provided a cartridge for an aerosolgenerating system, the cartridge comprising: a liquid storage portion comprising a liquid nicotine formulation according to the first aspect of the invention; and an atomiser in fluid communication with the liquid storage portion, wherein the atomiser is configured to vaporise the liquid nicotine formulation to generate an aerosol.

[0024] According to a third aspect of the invention there is provided an aerosol-generating system comprising: a cartridge according to the second aspect of the invention; and an aerosolgenerating device configured to be removably coupled to the cartridge.

[0025] According to a fourth aspect of the invention there is provided use of a combination of neotame, menthol, and WS-23 in a liquid nicotine formulation for use in an aerosol-generating system. P / 91070.W002

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[0027] According to the fourth aspect of the invention there is provided use of a combination of one or more monocarboxylic acids, neotame, menthol, and WS-23 in a liquid nicotine formulation for use in an aerosol-generating system.

[0028] According to the fourth aspect of the invention there is provided use of a combination of benzoic acid, neotame, menthol, and WS-23 in a liquid nicotine formulation for use in an aerosolgenerating system.

[0029] It has been found that inclusion of a combination of one or more monocarboxylic acids, one or more high intensity sweeteners and one or more cooling agents in the liquid nicotine formulation may advantageously improve the perceived flavour and reduce the perceived sensorial harshness of aerosols generated from liquid nicotine formulations according to the first aspect of the invention.

[0030] In particular, it has been found that inclusion of a combination of one or more monocarboxylic acids, one or more high intensity sweeteners and one or more cooling agents in the liquid nicotine formulation may advantageously improve the perceived flavour and reduce the perceived sensorial harshness of aerosols generated from liquid nicotine formulations according to the first aspect of the invention, without adversely impacting nicotine delivery.

[0031] It has been found to be particularly advantageous where liquid nicotine formulations according to the first aspect of the invention comprise a combination of a monocarboxylic acid, a high intensity sweetener, a monoterpene or monoterpenoid cooling agent, and a WS cooling agent.

[0032] Particularly preferred liquid nicotine formulations according to the first aspect of the invention comprise a combination of benzoic acid, neotame, menthol, and WS-23.

[0033] As used herein, the term “aerosol” describes a dispersion of solid particles, or liquid droplets, or a combination of solid particles and liquid droplets, in a gas. The aerosol may be visible or invisible. The aerosol may include vapours of substances that are ordinarily liquid or solid at room temperature as well as solid particles, or liquid droplets, or a combination of solid particles and liquid droplets.

[0034] As used herein, the term “liquid nicotine formulation” describes a liquid formulation comprising nicotine.

[0035] Unless stated otherwise, percentages by weight of components of the liquid nicotine formulation recited herein are based on the total weight of the liquid nicotine formulation.

[0036] The liquid nicotine formulation may comprise natural nicotine, or synthetic nicotine, or a combination of natural nicotine and synthetic nicotine.

[0037] The liquid nicotine formulation may have a nicotine content of greater than or equal to about 0.1 percent by weight, greater than or equal to about 0.2 percent by weight, greater than or equal to about 0.4 percent by weight, or greater than or equal to about 0.6 percent by weight. P / 91070.W002

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[0039] The liquid nicotine formulation may have a nicotine content of less than or equal to about 10 percent by weight, less than or equal to about 6 percent by weight, less than or equal to about

[0040] 5 percent by weight, or less than or equal to about 4 percent by weight.

[0041] The liquid nicotine formulation may have a nicotine content of between about 0.1 percent by weight and about 10 percent by weight, between about 0.1 percent by weight and about

[0042] 6 percent by weight, between about 0.1 percent by weight and about 5 percent by weight, or between about 0.1 percent by weight and about 4 percent by weight.

[0043] The liquid nicotine formulation may have a nicotine content of between about 0.2 percent by weight and about 10 percent by weight, between about 0.2 percent by weight and about 6 percent by weight, between about 0.2 percent by weight and about 5 percent by weight, or between about 0.2 percent by weight and about 4 percent by weight.

[0044] The liquid nicotine formulation may have a nicotine content of between about 0.4 percent by weight and about 10 percent by weight, between about 0.4 percent by weight and about 6 percent by weight, between about 0.4 percent by weight and about 5 percent by weight, or between about 0.4 percent by weight and about 4 percent by weight.

[0045] The liquid nicotine formulation may have a nicotine content of between about 0.6 percent by weight and about 10 percent by weight, between about 0.6 percent by weight and about 6 percent by weight, between about 0.6 percent by weight and about 5 percent by weight, or between about 0.6 percent by weight and about 4 percent by weight.

[0046] Preferably, the liquid nicotine formulation has a nicotine content of between about 0.1 percent by weight and about 10 percent by weight, between about 0.2 percent by weight and about 5 percent by weight, or between about 0.6 percent by weight and about 4 percent by weight.

[0047] For example, the liquid nicotine formulation may have a nicotine content of 0.8 percent by weight, about 1.6 percent by weight, about 1.8 percent by weight, or about 3.5 percent by weight.

[0048] The liquid nicotine formulation according to the first aspect of the invention comprises a liquid carrier.

[0049] The liquid nicotine formulation may have a liquid carrier content of greater than or equal to about 75 percent by weight, greater than or equal to about 80 percent by weight, greater than or equal to about 85 percent by weight, or greater than or equal to about 90 percent by weight.

[0050] The liquid nicotine formulation may have a liquid carrier content of less than or equal to about 98 percent by weight, less than or equal to about 97 percent by weight, less than or equal to about 96 percent by weight, or less than or equal to about 95 percent by weight.

[0051] The liquid nicotine formulation may have a liquid carrier content of between about 75 percent by weight and about 98 percent by weight, between about 75 percent by weight and about 97 percent by weight, between about 75 percent by weight and about 96 percent by weight, or between about 75 percent by weight and about 95 percent by weight. P / 91070.W002

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[0053] The liquid nicotine formulation may have a liquid carrier content of between about 80 percent by weight and about 98 percent by weight, between about 80 percent by weight and about 97 percent by weight, between about 80 percent by weight and about 96 percent by weight, or between about 80 percent by weight and about 95 percent by weight.

[0054] The liquid nicotine formulation may have a liquid carrier content of between about 85 percent by weight and about 98 percent by weight, between about 85 percent by weight and about 97 percent by weight, between about 85 percent by weight and about 96 percent by weight, or between about 85 percent by weight and about 95 percent by weight.

[0055] The liquid nicotine formulation may have a liquid carrier content of between about 90 percent by weight and about 98 percent by weight, between about 90 percent by weight and about 97 percent by weight, between about 90 percent by weight and about 96 percent by weight, or between about 90 percent by weight and about 95 percent by weight.

[0056] The liquid carrier may comprise one or more biologically acceptable solvents.

[0057] Preferably, the liquid carrier comprises one or more polyhydric alcohols.

[0058] As used herein, the term “total polyhydric alcohol content” describes the combined content of all polyhydric alcohols in the liquid nicotine formulation.

[0059] In embodiments in which the liquid carrier comprises one or more polyhydric alcohols, the liquid nicotine formulation may have a total polyhydric alcohol content of greater than or equal to about 75 percent by weight, greater than or equal to about 80 percent by weight, greater than or equal to about 85 percent by weight, or greater than or equal to about 90 percent by weight.

[0060] In embodiments in which the liquid carrier comprises one or more polyhydric alcohols, the liquid nicotine formulation may have a total polyhydric alcohol content of less than or equal to about 98 percent by weight, less than or equal to about 97 percent by weight, less than or equal to about 96 percent by weight, or less than or equal to about 95 percent by weight.

[0061] In embodiments in which the liquid carrier comprises one or more polyhydric alcohols, the liquid nicotine formulation may have a total polyhydric alcohol content of between about 75 percent by weight and about 98 percent by weight, between about 75 percent by weight and about 97 percent by weight, between about 75 percent by weight and about 96 percent by weight, or between about 75 percent by weight and about 95 percent by weight.

[0062] In embodiments in which the liquid carrier comprises one or more polyhydric alcohols, the liquid nicotine formulation may have a total polyhydric alcohol content of between about 80 percent by weight and about 98 percent by weight, between about 80 percent by weight and about 97 percent by weight, between about 80 percent by weight and about 96 percent by weight, or between about 80 percent by weight and about 95 percent by weight.

[0063] In embodiments in which the liquid carrier comprises one or more polyhydric alcohols, the liquid nicotine formulation may have a total polyhydric alcohol content of between about P / 91070.W002

[0064] - 7 -

[0065] 85 percent by weight and about 98 percent by weight, between about 85 percent by weight and about 97 percent by weight, between about 85 percent by weight and about 96 percent by weight, or between about 85 percent by weight and about 95 percent by weight.

[0066] In embodiments in which the liquid carrier comprises one or more polyhydric alcohols, the liquid nicotine formulation may have a total polyhydric alcohol content of between about 90 percent by weight and about 98 percent by weight, between about 90 percent by weight and about 97 percent by weight, between about 90 percent by weight and about 96 percent by weight, or between about 90 percent by weight and about 95 percent by weight.

[0067] Preferably, the liquid carrier comprises one or more polyhydric alcohols selected from 1 ,3- butanediol, glycerine, 1 ,3-propanediol, propylene glycol, and triethylene glycol.

[0068] More preferably, the liquid carrier comprises one or more polyhydric alcohols selected from propylene glycol and glycerine.

[0069] Even more preferably, the liquid carrier comprises propylene glycol and glycerine.

[0070] Most preferably, the liquid carrier comprises propylene glycol and vegetable glycerine.

[0071] In embodiments in which the liquid carrier comprises propylene glycol and glycerine, the liquid nicotine formulation may have a combined propylene glycol and glycerine content of greater than or equal to about 75 percent by weight, greater than or equal to about 80 percent by weight, greater than or equal to about 85 percent by weight, or greater than or equal to about 90 percent by weight.

[0072] In embodiments in which the liquid carrier comprises propylene glycol and glycerine, the liquid nicotine formulation may have a combined propylene glycol and glycerine content of less than or equal to about 98 percent by weight, less than or equal to about 97 percent by weight, less than or equal to about 96 percent by weight, or less than or equal to about 95 percent by weight.

[0073] In embodiments in which the liquid carrier comprises propylene glycol and glycerine, the liquid nicotine formulation may have a combined propylene glycol and glycerine content of between about 75 percent by weight and about 98 percent by weight, between about 75 percent by weight and about 97 percent by weight, between about 75 percent by weight and about 96 percent by weight, or between about 75 percent by weight and about 95 percent by weight.

[0074] In embodiments in which the liquid carrier comprises propylene glycol and glycerine, the liquid nicotine formulation may have a combined propylene glycol and glycerine content of between about 80 percent by weight and about 98 percent by weight, between about 80 percent by weight and about 97 percent by weight, between about 80 percent by weight and about 96 percent by weight, or between about 80 percent by weight and about 95 percent by weight.

[0075] In embodiments in which the liquid carrier comprises propylene glycol and glycerine, the liquid nicotine formulation may have a combined propylene glycol and glycerine content of P / 91070.W002

[0076] - 8 - between about 85 percent by weight and about 98 percent by weight, between about 85 percent by weight and about 97 percent by weight, between about 85 percent by weight and about 96 percent by weight, or between about 85 percent by weight and about 95 percent by weight.

[0077] In embodiments in which the liquid carrier comprises propylene glycol and glycerine, the liquid nicotine formulation may have a combined propylene glycol and glycerine content of between about 90 percent by weight and about 98 percent by weight, between about 90 percent by weight and about 97 percent by weight, between about 90 percent by weight and about 96 percent by weight, or between about 90 percent by weight and about 95 percent by weight.

[0078] Increasing the proportion of propylene glycol in the liquid nicotine formulation may improve the ability of the liquid nicotine formulation dissolve flavours.

[0079] Increasing the proportion of glycerine in the liquid nicotine formulation may increase the volume of visible aerosol generated from the liquid nicotine formulation.

[0080] In embodiments in which the liquid carrier comprises propylene glycol and glycerine, the ratio of the weight percent propylene glycol content to the weight percent glycerine content of the liquid nicotine formulation may be greater than or equal to about 3:5, greater than or equal to about 4:5, greater than or equal to about 1 :1 , or greater than or equal to about 6:5.

[0081] In embodiments in which the liquid carrier comprises propylene glycol and glycerine, the ratio of the weight percent propylene glycol content to the weight percent glycerine content of the liquid nicotine formulation may be less than or equal to about 2: 1 , less than or equal to about 9:5, less than or equal to about 8:5, or less than or equal to about 7:5.

[0082] In embodiments in which the liquid carrier comprises propylene glycol and glycerine, the ratio of the weight percent propylene glycol content to the weight percent glycerine content of the liquid nicotine formulation may be between about 3:5 and about 2: 1 , between about 3:5 and about 9:5, between about 3:5 and about 8:5, or between about 3:5 and about 7:5.

[0083] In embodiments in which the liquid carrier comprises propylene glycol and glycerine, the ratio of the weight percent propylene glycol content to the weight percent glycerine content of the liquid nicotine formulation may be between about 4:5 and about 2: 1 , between about 4:5 and about 9:5, between about 4:5 and about 8:5, or between about 4:5 and about 7:5.

[0084] In embodiments in which the liquid carrier comprises propylene glycol and glycerine, the ratio of the weight percent propylene glycol content to the weight percent glycerine content of the liquid nicotine formulation may be between about 1 : 1 and about 2: 1 , between about 1 : 1 and about 9:5, between about 1 :1 and about 8:5, or between about 1 :1 and about 7:5.

[0085] In embodiments in which the liquid carrier comprises propylene glycol and glycerine, the ratio of the weight percent propylene glycol content to the weight percent glycerine content of the liquid nicotine formulation may be between about 6:5 and about 2: 1 , between about 6:5 and about 9:5, between about 6:5 and about 8:5, or between about 6:5 and about 7:5. P / 91070.W002

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[0087] For example, in embodiments in which the liquid carrier comprises propylene glycol and glycerine, the ratio of the weight percent propylene glycol content to the weight percent glycerine content of the liquid nicotine formulation may be about 5:4.

[0088] In embodiments in which the liquid carrier comprises propylene glycol and glycerine, the liquid nicotine formulation may have a propylene glycol content of greater than or equal to about 20 percent by weight, greater than or equal to about 30 percent by weight, greater than or equal to about 40 percent by weight, or greater than or equal to about 45 percent by weight.

[0089] In embodiments in which the liquid carrier comprises propylene glycol and glycerine, the liquid nicotine formulation may have a propylene glycol content of less than or equal to about 80 percent by weight, less than or equal to about 70 percent by weight, less than or equal to about 60 percent by weight, or less than or equal to about 55 percent by weight.

[0090] In embodiments in which the liquid carrier comprises propylene glycol and glycerine, the liquid nicotine formulation may have a propylene glycol content of between about 20 percent by weight and about 80 percent by weight, between about 20 percent by weight and about 70 percent by weight, between about 20 percent by weight and about 60 percent by weight, or between about 20 percent by weight and about 55 percent by weight.

[0091] In embodiments in which the liquid carrier comprises propylene glycol and glycerine, the liquid nicotine formulation may have a propylene glycol content of between about 30 percent by weight and about 80 percent by weight, between about 30 percent by weight and about 70 percent by weight, between about 30 percent by weight and about 60 percent by weight, or between about 30 percent by weight and about 55 percent by weight.

[0092] In embodiments in which the liquid carrier comprises propylene glycol and glycerine, the liquid nicotine formulation may have a propylene glycol content of between about 40 percent by weight and about 80 percent by weight, between about 40 percent by weight and about 70 percent by weight, between about 40 percent by weight and about 60 percent by weight, or between about 40 percent by weight and about 55 percent by weight.

[0093] In embodiments in which the liquid carrier comprises propylene glycol and glycerine, the liquid nicotine formulation may have a propylene glycol content of between about 45 percent by weight and about 80 percent by weight, between about 45 percent by weight and about 70 percent by weight, between about 45 percent by weight and about 60 percent by weight, or between about 45 percent by weight and about 55 percent by weight.

[0094] Preferably, the liquid nicotine formulation has a propylene glycol content of between about 20 percent by weight and about 80 percent by weight, between about 40 percent by weight and about 60 percent by weight, or between about 45 percent by weight and about 55 percent by weight. P / 91070.W002

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[0096] In embodiments in which the liquid carrier comprises propylene glycol and glycerine, the liquid nicotine formulation may have a glycerine content of greater than or equal to about 20 percent by weight, greater than or equal to about 25 percent by weight, greater than or equal to about 30 percent by weight, or greater than or equal to about 35 percent by weight.

[0097] In embodiments in which the liquid carrier comprises propylene glycol and glycerine, the liquid nicotine formulation may have a glycerine content of less than or equal to about 80 percent by weight, less than or equal to about 70 percent by weight, less than or equal to about 60 percent by weight, or less than or equal to about 45 percent by weight.

[0098] In embodiments in which the liquid carrier comprises propylene glycol and glycerine, the liquid nicotine formulation may have a glycerine content of between about 20 percent by weight and about 80 percent by weight, between about 20 percent by weight and about 70 percent by weight, between about 20 percent by weight and about 60 percent by weight, or between about 20 percent by weight and about 45 percent by weight.

[0099] In embodiments in which the liquid carrier comprises propylene glycol and glycerine, the liquid nicotine formulation may have a glycerine content of between about 25 percent by weight and about 80 percent by weight, between about 25 percent by weight and about 70 percent by weight, between about 25 percent by weight and about 60 percent by weight, or between about 25 percent by weight and about 45 percent by weight.

[0100] In embodiments in which the liquid carrier comprises propylene glycol and glycerine, the liquid nicotine formulation may have a glycerine content of between about 30 percent by weight and about 80 percent by weight, between about 30 percent by weight and about 70 percent by weight, between about 30 percent by weight and about 60 percent by weight, or between about 30 percent by weight and about 45 percent by weight.

[0101] In embodiments in which the liquid carrier comprises propylene glycol and glycerine, the liquid nicotine formulation may have a glycerine content of between about 35 percent by weight and about 80 percent by weight, between about 35 percent by weight and about 70 percent by weight, between about 35 percent by weight and about 60 percent by weight, or between about 35 percent by weight and about 45 percent by weight.

[0102] Preferably, the liquid nicotine formulation has a glycerine content of between about 20 percent by weight and about 80 percent by weight, between about 30 percent by weight and about 60 percent by weight, or between about 35 percent by weight and about 45 percent by weight.

[0103] The liquid carrier may be a non-aqueous liquid carrier.

[0104] As used herein, the term “non-aqueous liquid carrier” means that one or more solvents other than water are used as the liquid carrier in the liquid nicotine formulation. P / 91070.W002

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[0106] It will be appreciated that a liquid nicotine formulation comprising a non-aqueous liquid carrier may not be entirely water-free. In particular, it will be appreciated that trace amounts of water may be present in one or more solvents other than water used to prepare the non-aqueous liquid carrier. It will also be appreciated that trace amounts of water may be present in one or more components other than the liquid carrier used to prepare the liquid nicotine formulation.

[0107] As used herein, the term “non-aqueous liquid carrier” describes a liquid carrier having a water content of less than 1 percent by weight.

[0108] The liquid nicotine formulation comprises one or more monocarboxylic acids.

[0109] As used herein, the term “monocarboxylic acid” describes a carboxylic acid containing a single carboxyl group (-COOH).

[0110] The liquid nicotine formulation may comprise a single monocarboxylic acid.

[0111] The liquid nicotine formulation may comprise a plurality of monocarboxylic acids. For example, the liquid nicotine formulation may comprise two monocarboxylic acids, three monocarboxylic acids, or four carboxylic acids.

[0112] Preferably, the liquid nicotine formulation comprises one or more monocarboxylic acids selected from acetic acid, benzoic acid, lactic acid, levulinic acid, and salicyclic acid.

[0113] More preferably, the liquid nicotine formulation comprises one or more monocarboxylic acids selected from acetic acid, benzoic acid, lactic acid, and levulinic acid.

[0114] Even more preferably, the liquid nicotine formulation comprises one or more monocarboxylic acids selected from benzoic acid and lactic acid.

[0115] Most preferably, the liquid nicotine formulation comprises benzoic acid.

[0116] The liquid nicotine formulation may comprise a combination of benzoic acid and lactic acid.

[0117] In embodiments in which the liquid nicotine formulation comprises benzoic acid, the molar ratio of benzoic acid to nicotine in the liquid nicotine formulation may be greater than or equal to about 0.2:1 , greater than or equal to about 0.3:1 , greater than or equal to about 0.4:1 , or greater than or equal to about 0.5: 1.

[0118] In embodiments in which the liquid nicotine formulation comprises benzoic acid, the molar ratio of benzoic acid to nicotine in the liquid nicotine formulation may be less than or equal to about 1 :1 , less than or equal to about 0.9:1 , less than or equal to about 0.8:1 , or less than or equal to about 0.7:1.

[0119] In embodiments in which the liquid nicotine formulation comprises benzoic acid, the molar ratio of benzoic acid to nicotine in the liquid nicotine formulation may be between about 0.2:1 and about 1 :1 , between about 0.2: 1 and about 0.9:1 , between about 0.2: 1 and about 0.8:1 , or between about 0.2:1 and about 0.7:1. P / 91070.W002

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[0121] In embodiments in which the liquid nicotine formulation comprises benzoic acid, the molar ratio of benzoic acid to nicotine in the liquid nicotine formulation may be between about 0.3:1 and about 1 :1 , between about 0.3: 1 and about 0.9: 1 .between about 0.3: 1 and about 0.8:1 , or between about 0.3:1 and about 0.7:1.

[0122] In embodiments in which the liquid nicotine formulation comprises benzoic acid, the molar ratio of benzoic acid to nicotine in the liquid nicotine formulation may be between about 0.4:1 and about 1 :1 , between about 0.4: 1 and about 0.9: 1 .between about 0.4: 1 and about 0.8:1 , or between about 0.4:1 and about 0.7:1.

[0123] In embodiments in which the liquid nicotine formulation comprises benzoic acid, the molar ratio of benzoic acid to nicotine in the liquid nicotine formulation may be between about 0.5:1 and about 1 :1 , between about 0.5: 1 and about 0.9: 1 .between about 0.5: 1 and about 0.8:1 , or between about 0.5:1 and about 0.7:1.

[0124] In addition to one or more monocarboxylic acids, the liquid nicotine formulation may comprise one or more polycarboxylic acids.

[0125] As used herein, the term “polycarboxylic acid” describes a carboxylic acid containing two or more carboxyl groups (-COOH).

[0126] For example, the liquid nicotine formulation may comprise one or more polycarboxylic acids selected from acetic acid, adipic acid, citric acid, fumaric acid, malic acid, maleic acid, malonic acid, succinic acid, and tartaric acid.

[0127] As used herein, the term “total carboxylic acid content” describes the combined content of all carboxylic acids in the liquid nicotine formulation. Where the liquid nicotine formulation comprises one or more monocarboxylic acids and one or more polycarboxylic acids, the term “total carboxylic acid content” describes the combined monocarboxylic acid content and polycarboxylic acid content of the liquid nicotine formulation. For example, if the liquid nicotine formulation comprises benzoic acid and fumaric acid, the term “total carboxylic acid content” describes the combined benzoic acid content and fumaric acid content of the liquid nicotine formulation.

[0128] The liquid nicotine formulation may have a total carboxylic acid content of greater than or equal to about 0.1 percent by weight, greater than or equal to about 0.2 percent by weight, greater than or equal to about 0.3 percent by weight, greater than or equal to about 0.4 percent by weight, or greater than or equal to about 0.5 percent by weight

[0129] The liquid nicotine formulation may have a total carboxylic acid content of less than or equal to about 7 percent by weight, less than or equal to about 6 percent by weight, less than or equal to about 5 percent by weight, less than or equal to about 4 percent by weight, or less than or equal to about 3 percent by weight. P / 91070.W002

[0130] - 13 -

[0131] The liquid nicotine formulation may have a total carboxylic acid content of between about 0.1 percent by weight and about 7 percent by weight, between about 0.1 percent by weight and about 6 percent by weight, between about 0.1 percent by weight and about 5 percent by weight, between about 0.1 percent by weight and about 4 percent by weight, or between about 0.1 percent by weight and about 3 percent by weight.

[0132] The liquid nicotine formulation may have a total carboxylic acid content of between about 0.2 percent by weight and about 7 percent by weight, between about 0.2 percent by weight and about 6 percent by weight, between about 0.2 percent by weight and about 5 percent by weight, between about 0.2 percent by weight and about 4 percent by weight, or between about 0.2 percent by weight and about 3 percent by weight.

[0133] The liquid nicotine formulation may have a total carboxylic acid content of between about 0.3 percent by weight and about 7 percent by weight, between about 0.3 percent by weight and about 6 percent by weight, between about 0.3 percent by weight and about 5 percent by weight, between about 0.3 percent by weight and about 4 percent by weight, or between about 0.3 percent by weight and about 3 percent by weight.

[0134] The liquid nicotine formulation may have a total carboxylic acid content of between about 0.4 percent by weight and about 7 percent by weight, between about 0.4 percent by weight and about 6 percent by weight, between about 0.4 percent by weight and about 5 percent by weight, between about 0.4 percent by weight and about 4 percent by weight, or between about 0.4 percent by weight and about 3 percent by weight.

[0135] The liquid nicotine formulation may have a total carboxylic acid content of between about 0.5 percent by weight and about 7 percent by weight, between about 0.5 percent by weight and about 6 percent by weight, between about 0.5 percent by weight and about 5 percent by weight, between about 0.5 percent by weight and about 4 percent by weight, or between about 0.5 percent by weight and about 3 percent by weight.

[0136] The liquid nicotine formulation comprises one or more high-intensity sweeteners.

[0137] As used herein, the term “high-intensity sweetener” describes a sugar substitute that is sweeter than sucrose.

[0138] The liquid nicotine formulation may comprise a single high-intensity sweetener.

[0139] The liquid nicotine formulation may comprise a plurality of high-intensity sweeteners. For example, the liquid nicotine formulation may comprise two high-intensity sweeteners, three high- intensity sweeteners, or four high-intensity sweeteners.

[0140] Preferably, the liquid nicotine formulation comprises one or more high-intensity sweeteners selected from advantame, acesulfame potassium, aspartame, cyclamates, glycyrrhizin, mogrosides, neotame, saccharin, steviol glycosides, and sucralose. P / 91070.W002

[0141] - 14 -

[0142] More preferably, the liquid nicotine formulation comprises one or more high-intensity sweeteners selected from advantame, acesulfame potassium, cyclamates, glycyrrhizin, mogrosides, neotame, saccharin, steviol glycosides, and sucralose.

[0143] Most preferably, the liquid nicotine formulation comprises neotame.

[0144] As used herein, the term “total high-intensity sweetener content” describes the combined content of all high-intensity sweeteners in the liquid nicotine formulation. For example, if the liquid nicotine formulation comprises neotame and sucralose, the term “total high-intensity sweetener content” describes the combined neotame content and sucralose content of the liquid nicotine formulation.

[0145] The liquid nicotine formulation may have a total high-intensity sweetener content of greater than or equal to about 0.01 percent by weight, greater than or equal to about 0.02 percent by weight, greater than or equal to about 0.03 percent by weight, greater than or equal to about 0.04 percent by weight, or greater than or equal to about 0.05 percent by weight.

[0146] The liquid nicotine formulation may have a total high-intensity sweetener content of less than or equal to about 2 percent by weight, less than or equal to about 1.5 percent by weight, less than or equal to about 1 percent by weight, less than or equal to about 0.75 percent by weight, or less than or equal to about 0.5 percent by weight.

[0147] The liquid nicotine formulation may have a total high-intensity sweetener content of between about 0.01 percent by weight and about 2 percent by weight, between about 0.01 percent by weight and about 1.5 percent by weight, between about 0.01 percent by weight and about 1 percent by weight, between about 0.01 percent by weight and about 0.75 percent by weight, or between about 0.01 percent by weight and about 0.5 percent by weight.

[0148] The liquid nicotine formulation may have a total high-intensity sweetener content of between about 0.02 percent by weight and about 2 percent by weight, between about 0.02 percent by weight and about 1.5 percent by weight, between about 0.02 percent by weight and about 1 percent by weight, between about 0.02 percent by weight and about 0.75 percent by weight, or between about 0.02 percent by weight and about 0.5 percent by weight.

[0149] The liquid nicotine formulation may have a total high-intensity sweetener content of between about 0.03 percent by weight and about 2 percent by weight, between about 0.03 percent by weight and about 1.5 percent by weight, between about 0.03 percent by weight and about 1 percent by weight, between about 0.03 percent by weight and about 0.75 percent by weight, or between about 0.03 percent by weight and about 0.5 percent by weight.

[0150] The liquid nicotine formulation may have a total high-intensity sweetener content of between about 0.04 percent by weight and about 2 percent by weight, between about 0.04 percent by weight and about 1.5 percent by weight, between about 0.04 percent by weight P / 91070.W002

[0151] - 15 - and about 1 percent by weight, between about 0.04 percent by weight and about 0.75 percent by weight, or between about 0.04 percent by weight and about 0.5 percent by weight.

[0152] The liquid nicotine formulation may have a total high-intensity sweetener content of between about 0.05 percent by weight and about 2 percent by weight, between about 0.05 percent by weight and about 1.5 percent by weight, between about 0.05 percent by weight and about 1 percent by weight, between about 0.05 percent by weight and about 0.75 percent by weight, or between about 0.05 percent by weight and about 0.5 percent by weight.

[0153] The ratio of the weight percent total high-intensity sweetener content to the weight percent nicotine content of the liquid nicotine formulation may be greater than or equal to about 1 :200, greater than or equal to 1 :160, greater than or equal to about 1 :120, or greater than or equal to about 1 :80.

[0154] The ratio of the weight percent total high-intensity sweetener content to the weight percent nicotine content of the liquid nicotine formulation may be less than or equal to about 1 :1 , less than or equal to about 1 :2, less than or equal to about 1 :4, or less than or equal to about 1 :10.

[0155] The ratio of the weight percent total high-intensity sweetener content to the weight percent nicotine content of the liquid nicotine formulation may be between about 1 :200 and about 1 :1 , between about 1 :200 and about 1 :2, between about 1 :200 and about 1 :4, or between about 1 :200 and about 1 :10.

[0156] The ratio of the weight percent total high-intensity sweetener content to the weight percent nicotine content of the liquid nicotine formulation may be between about 1 :160 and about 1 :1 , between about 1 :160 and about 1 :2, between about 1 :160 and about 1 :4, or between about 1 :160 and about 1 :10.

[0157] The ratio of the weight percent total high-intensity sweetener content to the weight percent nicotine content of the liquid nicotine formulation may be between about 1 :120 and about 1 :1 , between about 1 :120 and about 1 :2, between about 1 :120 and about 1 :4, or between about 1 :120 and about 1 :10.

[0158] The ratio of the weight percent total high-intensity sweetener content to the weight percent nicotine content of the liquid nicotine formulation may be between about 1 :80 and about 1 :1 , between about 1 :80 and about 1 :2, between about 1 :80 and about 1 :4, or between about 1 :80 and about 1 :10.

[0159] In embodiments in which the liquid nicotine formulation comprises neotame, the liquid nicotine formulation may have a neotame content of greater than or equal to about 0.01 percent by weight, greater than or equal to about 0.02 percent by weight, greater than or equal to about 0.03 percent by weight, greater than or equal to about 0.04 percent by weight, or greater than or equal to about 0.05 percent by weight. P / 91070.W002

[0160] - 16 -

[0161] In embodiments in which the liquid nicotine formulation comprises neotame, the liquid nicotine formulation may have a neotame content of less than or equal to about 1 percent by weight, less than or equal to about 0.8 percent by weight, less than or equal to about 0.6 percent by weight, less than or equal to about 0.5 percent by weight, or less than or equal to about 0.4 percent by weight.

[0162] In embodiments in which the liquid nicotine formulation comprises neotame, the liquid nicotine formulation may have a neotame content of between about 0.01 percent by weight and about 1 percent by weight, between about 0.01 percent by weight and about 0.8 percent by weight, between about 0.01 percent by weight and about 0.6 percent by weight, between about 0.01 percent by weight and about 0.5 percent by weight, or between about 0.01 percent by weight and about 0.4 percent by weight.

[0163] In embodiments in which the liquid nicotine formulation comprises neotame, the liquid nicotine formulation may have a neotame content of between about 0.02 percent by weight and about 1 percent by weight, between about 0.02 percent by weight and about 0.8 percent by weight, between about 0.02 percent by weight and about 0.6 percent by weight, between about 0.02 percent by weight and about 0.5 percent by weight, or between about 0.02 percent by weight and about 0.4 percent by weight.

[0164] In embodiments in which the liquid nicotine formulation comprises neotame, the liquid nicotine formulation may have a neotame content of between about 0.03 percent by weight and about 1 percent by weight, between about 0.03 percent by weight and about 0.8 percent by weight, between about 0.03 percent by weight and about 0.6 percent by weight, between about 0.03 percent by weight and about 0.5 percent by weight, or between about 0.03 percent by weight and about 0.4 percent by weight.

[0165] In embodiments in which the liquid nicotine formulation comprises neotame, the liquid nicotine formulation may have a neotame content of between about 0.04 percent by weight and about 1 percent by weight, between about 0.04 percent by weight and about 0.8 percent by weight, between about 0.04 percent by weight and about 0.6 percent by weight, between about 0.04 percent by weight and about 0.5 percent by weight, or between about 0.04 percent by weight and about 0.4 percent by weight.

[0166] In embodiments in which the liquid nicotine formulation comprises neotame, the liquid nicotine formulation may have a neotame content of between about 0.05 percent by weight and about 1 percent by weight, between about 0.05 percent by weight and about 0.8 percent by weight, between about 0.05 percent by weight and about 0.6 percent by weight, between about 0.05 percent by weight and about 0.5 percent by weight, or between about 0.05 percent by weight and about 0.4 percent by weight. P / 91070.W002

[0167] - 17 -

[0168] The ratio of the weight percent neotame content to the weight percent nicotine content of the liquid nicotine formulation may be greater than or equal to about 1 :200, greater than or equal to about 1 :160, greater than or equal to about 1 :120, or greater than or equal to about 1 :80.

[0169] The ratio of the weight percent neotame content to the weight percent nicotine content of the liquid nicotine formulation may be less than or equal to about 1 :1 , less than or equal to about 1 :2, less than or equal to about 1 :4, or less than or equal to about 1 :10.

[0170] The ratio of the weight percent neotame content to the weight percent nicotine content of the liquid nicotine formulation may be between about 1 :200 and about 1 :1 , between about 1 :200 and about 1 :2, between about 1 :200 and about 1 :4, or between about 1 :200 and about 1 :10.

[0171] The ratio of the weight percent neotame content to the weight percent nicotine content of the liquid nicotine formulation may be between about 1 :160 and about 1 :1 , between about 1 :160 and about 1 :2, between about 1 :160 and about 1 :4, or between about 1 :160 and about 1 :10.

[0172] The ratio of the weight percent neotame content to the weight percent nicotine content of the liquid nicotine formulation may be between about 1 :120 and about 1 :1 , between about 1 :120 and about 1 :2, between about 1 :120 and about 1 :4, or between about 1 :120 and about 1 :10.

[0173] The ratio of the weight percent neotame content to the weight percent nicotine content of the liquid nicotine formulation may be between about 1 :80 and about 1 :1 , between about 1 :80 and about 1 :2, between about 1 :80 and about 1 :4, or between about 1 :80 and about 1 :10.

[0174] The liquid nicotine formulation comprises one or more cooling agents.

[0175] As used herein, the term “cooling agent” describes a cold receptor agonist. For example, a TRPM8 receptor agonist.

[0176] The liquid nicotine formulation may comprise one or more cooling agents that are flavourants.

[0177] The liquid nicotine formulation may comprise one or more cooling agents that are not flavourants.

[0178] The liquid nicotine formulation may comprise a single cooling agent.

[0179] The liquid nicotine formulation may comprise a plurality of cooling agents. For example, the liquid nicotine formulation may comprise two cooling agents, three cooling agents, or four cooling agents.

[0180] The liquid nicotine formulation may comprise one or more monoterpene or monoterpenoid cooling agents.

[0181] The liquid nicotine formulation may comprise one or more monoterpene or monoterpenoid cooling agents selected from L-carvone, isomenthone, isomenthyl acetate, menthol, menthone, menthyl acetate, menthyl lactate, and menthyl isovalerate.

[0182] The liquid nicotine formulation may comprise one or more WS (Wilkinson Sword) cooling agents. P / 91070.W002

[0183] - 18 -

[0184] The liquid nicotine formulation may comprise one or more WS (Wilkinson Sword) cooling agents selected from WS-3 (N-Ethyl-5-Methyl-2-(1-Methylethyl)-carboxamide), WS-5 (N- (Ethoxycarbonylmethyl)-3-p-menthanecarboxamide), WS-12 ((1 R,2S,5R)-N-(4-Methoxyphenyl)- 5-methyl-2-(1- methylethyl)cyclohexanecarboxamide), and WS-23 (N,2,3-trimethyl-2-(1- methylethyl)-butanamide).

[0185] Preferably, the liquid nicotine formulation comprises one or more cooling agents selected from isomenthone, isomenthyl acetate, isopulegone, L-carvone, menthol, menthone, menthyl acetate, menthyl lactate, menthyl isovalerate, WS-3, WS-5, WS-12, and WS-23.

[0186] Preferably, the liquid nicotine formulation comprises menthol.

[0187] As used herein, the term “menthol” is used to describe the compound 2-isopropyl-5- methylcyclohexanol in any of its isomeric forms.

[0188] In embodiments in which the liquid nicotine formulation comprises menthol, the liquid nicotine formulation may have a menthol content of greater than or equal to about 0.75 percent by weight, greater than or equal to about 1 percent by weight, greater than or equal to about 1.25 percent by weight, greater than or equal to about 1.5 percent by weight, or greater than or equal to about 1.75 percent by weight.

[0189] In embodiments in which the liquid nicotine formulation comprises menthol, the liquid nicotine formulation may have a menthol content of less than or equal to about 6 percent by weight, less than or equal to about 5 percent by weight, less than or equal to about 4 percent by weight, less than or equal to about 3 percent by weight, or less than or equal to about 2.5 percent by weight.

[0190] In embodiments in which the liquid nicotine formulation comprises menthol, the liquid nicotine formulation may have a menthol content of between about 0.75 percent by weight and about 6 percent by weight, between about 0.75 percent by weight and about 5 percent by weight, between about 0.75 percent by weight and about 4 percent by weight, between about 0.75 percent by weight and about 3 percent by weight, or between about 0.75 percent by weight and about 2.5 percent by weight.

[0191] In embodiments in which the liquid nicotine formulation comprises menthol, the liquid nicotine formulation may have a menthol content of between about 1 percent by weight and about 6 percent by weight, between about 1 percent by weight and about 5 percent by weight, between about 1 percent by weight and about 4 percent by weight, between about 1 percent by weight and about 3 percent by weight, or between about 1 percent by weight and about 2.5 percent by weight.

[0192] In embodiments in which the liquid nicotine formulation comprises menthol, the liquid nicotine formulation may have a menthol content of between about 1.25 percent by weight and about 6 percent by weight, between about 1.25 percent by weight and about 5 percent by weight, between about 1.25 percent by weight and about 4 percent by weight, between about P / 91070.W002

[0193] - 19 -

[0194] 1.25 percent by weight and about 3 percent by weight, or between about 1.25 percent by weight and about 2.5 percent by weight.

[0195] In embodiments in which the liquid nicotine formulation comprises menthol, the liquid nicotine formulation may have a menthol content of between about 1.5 percent by weight and about 6 percent by weight, between about 1 .5 percent by weight and about 5 percent by weight, between about 1.5 percent by weight and about 4 percent by weight, between about 1.5 percent by weight and about 3 percent by weight, or between about 1 .5 percent by weight and about 2.5 percent by weight.

[0196] In embodiments in which the liquid nicotine formulation comprises menthol, the liquid nicotine formulation may have a menthol content of between about 1.75 percent by weight and about 6 percent by weight, between about 1.75 percent by weight and about 5 percent by weight, between about 1.75 percent by weight and about 4 percent by weight, between about 1.75 percent by weight and about 3 percent by weight, or between about 1.75 percent by weight and about 2.5 percent by weight.

[0197] Preferably, the liquid nicotine formulation comprises WS-23.

[0198] In embodiments in which the liquid nicotine formulation comprises WS-23, the liquid nicotine formulation may have a WS-23 content of greater than or equal to about 0.25 percent by weight, greater than or equal to about 0.3 percent by weight, greater than or equal to about 0.35 percent by weight, greater than or equal to about 0.4 percent by weight, or greater than or equal to about 0.45 percent by weight

[0199] In embodiments in which the liquid nicotine formulation comprises WS-23, the liquid nicotine formulation may have a WS-23 content of less than or equal to about 2 percent by weight, less than or equal to about 1.75 percent by weight, less than or equal to about 1.5 percent by weight, less than or equal to about 1.25 percent by weight, or less than or equal to about 1 percent by weight.

[0200] In embodiments in which the liquid nicotine formulation comprises WS-23, the liquid nicotine formulation may have a WS-23 content of between about 0.25 percent by weight and about 2 percent by weight, between about 0.25 percent by weight and about 1.75 percent by weight, between about 0.25 percent by weight and about 1.5 percent by weight, between about 0.25 percent by weight and about 1.25 percent by weight, or between about 0.25 percent by weight and about 1 percent by weight.

[0201] In embodiments in which the liquid nicotine formulation comprises WS-23, the liquid nicotine formulation may have a WS-23 content of between about 0.3 percent by weight and about 2 percent by weight, between about 0.3 percent by weight and about 1.75 percent by weight, between about 0.3 percent by weight and about 1.5 percent by weight, between about 0.3 percent P / 91070.W002

[0202] - 20 - by weight and about 1.25 percent by weight, or between about 0.3 percent by weight and about

[0203] 1 percent by weight.

[0204] In embodiments in which the liquid nicotine formulation comprises WS-23, the liquid nicotine formulation may have a WS-23 content of between about 0.35 percent by weight and about 2 percent by weight, between about 0.35 percent by weight and about 1.75 percent by weight, between about 0.35 percent by weight and about 1.5 percent by weight, between about 0.35 percent by weight and about 1.25 percent by weight, or between about 0.35 percent by weight and about 1 percent by weight.

[0205] In embodiments in which the liquid nicotine formulation comprises WS-23, the liquid nicotine formulation may have a WS-23 content of between about 0.4 percent by weight and about

[0206] 2 percent by weight, between about 0.4 percent by weight and about 1.75 percent by weight, between about 0.4 percent by weight and about 1.5 percent by weight, between about 0.4 percent by weight and about 1.25 percent by weight, or between about 0.4 percent by weight and about 1 percent by weight.

[0207] In embodiments in which the liquid nicotine formulation comprises WS-23, the liquid nicotine formulation may have a WS-23 content of between about 0.45 percent by weight and about 2 percent by weight, between about 0.45 percent by weight and about 1.75 percent by weight, between about 0.45 percent by weight and about 1.5 percent by weight, between about 0.45 percent by weight and about 1.25 percent by weight, or between about 0.45 percent by weight and about 1 percent by weight.

[0208] As used herein, the term “total cooling agent content” describes the combined content of all cooling agents in the liquid nicotine formulation. For example, if the liquid nicotine formulation comprises menthol and WS-23, the term “total cooling agent content” describes the combined menthol content and WS-23 content of the liquid nicotine formulation.

[0209] The liquid nicotine formulation may have a total cooling agent content of greater than or equal to about 1 percent by weight, greater than or equal to about 1 .25 percent by weight, greater than or equal to about 1.5 percent by weight, greater than or equal to about 1.75 percent by weight, or greater than or equal to about 2 percent by weight.

[0210] The liquid nicotine formulation may have a total cooling agent content of less than or equal to about 8 percent by weight, less than or equal to about 6 percent by weight, less than or equal to about 5 percent by weight, less than or equal to about 4 percent by weight, or less than or equal to about 3 percent by weight.

[0211] The liquid nicotine formulation may have a total cooling agent content of between about 1 percent by weight and about 8 percent by weight, between about 1 percent by weight and about 6 percent by weight, between about 1 percent by weight and about 5 percent by weight, between P / 91070.W002

[0212] - 21 - about 1 percent by weight and about 4 percent by weight, or between about 1 percent by weight and about 3 percent by weight.

[0213] The liquid nicotine formulation may have a total cooling agent content of between about 1.25 percent by weight and about 8 percent by weight, between about 1.25 percent by weight and about 6 percent by weight, between about 1.25 percent by weight and about 5 percent by weight, between about 1.25 percent by weight and about 4 percent by weight, or between about 1.25 percent by weight and about 3 percent by weight.

[0214] The liquid nicotine formulation may have a total cooling agent content of between about 1.5 percent by weight and about 8 percent by weight, between about 1.5 percent by weight and about 6 percent by weight, between about 1 .5 percent by weight and about 5 percent by weight, between about 1 .5 percent by weight and about 4 percent by weight, or between about 1.5 percent by weight and about 3 percent by weight.

[0215] The liquid nicotine formulation may have a total cooling agent content of between about 1.75 percent by weight and about 8 percent by weight, between about 1.75 percent by weight and about 6 percent by weight, between about 1.75 percent by weight and about 5 percent by weight, between about 1.75 percent by weight and about 4 percent by weight, or between about 1.75 percent by weight and about 3 percent by weight.

[0216] The liquid nicotine formulation may have a total cooling agent content of between about 2 percent by weight and about 8 percent by weight, between about 2 percent by weight and about 6 percent by weight, between about 2 percent by weight and about 5 percent by weight, between about 2 percent by weight and about 4 percent by weight, or between about 2 percent by weight and about 3 percent by weight.

[0217] The ratio of the weight percent total cooling agent content to the weight percent nicotine content of the liquid nicotine formulation may be greater than or equal to about 1 :4, greater than or equal to 1 :3, greater than or equal to about 1 :2, or greater than or equal to about 2:3.

[0218] The ratio of the weight percent total cooling agent content to the weight percent nicotine content of the liquid nicotine formulation may be less than or equal to about 8: 1 , less than or equal to about 6: 1 , less than or equal to about 5:1 , or less than or equal to about 4: 1.

[0219] The ratio of the weight percent cooling agent content to the weight percent nicotine content of the liquid nicotine formulation may be between about 1 :4 and about 8:1 , between about 1 :4 and about 6: 1 , between about 1 :4 and about 5: 1 , or between about 1 :4 and about 4: 1.

[0220] The ratio of the weight percent cooling agent content to the weight percent nicotine content of the liquid nicotine formulation may be between about 1 :3 and about 8:1 , between about 1 :3 and about 6: 1 , between about 1 :3 and about 5: 1 , or between about 1 :3 and about 4: 1. P / 91070.W002

[0221] - 22 -

[0222] The ratio of the weight percent cooling agent content to the weight percent nicotine content of the liquid nicotine formulation may be between about 1 :2 and about 8:1 , between about 1 :2 and about 6: 1 , between about 1 :2 and about 5: 1 , or between about 1 :2 and about 4: 1.

[0223] The ratio of the weight percent cooling agent content to the weight percent nicotine content of the liquid nicotine formulation may be between about 2:3 and about 8:1 , between about 2:3 and about 6: 1 , between about 2:3 and about 5: 1 , or between about 2:3 and about 4: 1.

[0224] The ratio of the weight percent total cooling agent content to the weight percent total high- intensity sweetener content of the liquid nicotine formulation may be greater than or equal to about 25: 1 , greater than or equal to about 30: 1 , greater than or equal to about 35: 1 , or greater than or equal to about 40:1.

[0225] The ratio of the weight percent total cooling agent content to the weight percent total high- intensity sweetener content of the liquid nicotine formulation may be less than or equal to about 65:1 , less than or equal to about 60:1 , less than or equal to about 55:1 , or less than or equal to about 50:1.

[0226] The ratio of the weight percent total cooling agent content to the weight percent total high- intensity sweetener content of the liquid nicotine formulation may be between about 25:1 and about 65: 1 , between about 25: 1 and about 60: 1 , between about 25: 1 and about 55: 1 , or between about 25: 1 and about 50: 1.

[0227] The ratio of the weight percent total cooling agent content to the weight percent total high- intensity sweetener content of the liquid nicotine formulation may be between about 30:1 and about 65: 1 , between about 30: 1 and about 60: 1 , between about 30: 1 and about 55: 1 , or between about 30: 1 and about 50: 1.

[0228] The ratio of the weight percent total cooling agent content to the weight percent total high- intensity sweetener content of the liquid nicotine formulation may be between about 35:1 and about 65: 1 , between about 35: 1 and about 60: 1 , between about 35: 1 and about 55: 1 , or between about 35: 1 and about 50: 1.

[0229] The ratio of the weight percent total cooling agent content to the weight percent total high- intensity sweetener content of the liquid nicotine formulation may be between about 40:1 and about 65: 1 , between about 40: 1 and about 60: 1 , between about 40: 1 and about 55: 1 , or between about 40: 1 and about 50: 1.

[0230] In embodiments in which the liquid nicotine formulation comprises neotame, the ratio of the weight percent total cooling agent content to the weight percent neotame content of the liquid nicotine formulation may be less than or equal to about 65:1 , less than or equal to about 60:1 , less than or equal to about 55: 1 , or less than or equal to about 50: 1.

[0231] In embodiments in which the liquid nicotine formulation comprises neotame, the ratio of the weight percent total cooling agent content to the weight percent neotame content of the liquid P / 91070.W002

[0232] - 23 - nicotine formulation may be between about 25:1 and about 65:1 , between about 25:1 and about 60: 1 , between about 25: 1 and about 55: 1 , or between about 25: 1 and about 50: 1.

[0233] In embodiments in which the liquid nicotine formulation comprises neotame, the ratio of the weight percent total cooling agent content to the weight percent neotame content of the liquid nicotine formulation may be between about 30:1 and about 65:1 , between about 30:1 and about 60: 1 , between about 30: 1 and about 55: 1 , or between about 30: 1 and about 50: 1.

[0234] In embodiments in which the liquid nicotine formulation comprises neotame, the ratio of the weight percent total cooling agent content to the weight percent neotame content of the liquid nicotine formulation may be between about 35:1 and about 65:1 , between about 35:1 and about 60:1 , between about 35:1 and about 55:1 , or between about 35:1 and about 50:1.

[0235] In embodiments in which the liquid nicotine formulation comprises neotame, the ratio of the weight percent total cooling agent content to the weight percent neotame content of the liquid nicotine formulation may be between about 40:1 and about 65:1 , between about 40:1 and about 60: 1 , between about 40: 1 and about 55: 1 , or between about 40: 1 and about 50: 1 .

[0236] Preferably, the liquid nicotine formulation comprises a first cooling agent and a second cooling agent.

[0237] More preferably, the liquid nicotine formulation comprises a first cooling agent and a second cooling agent, wherein the first cooling agent is a monoterpene or monoterpenoid cooling agent and the second cooling agent is a WS cooling agent.

[0238] Even preferably, the liquid nicotine formulation comprises: a first cooling agent selected from isomenthone, isomenthyl acetate, isopulegone, L-carvone, menthol, menthone, menthyl acetate, menthyl lactate, and menthyl isovalerate; and a second cooling agent selected from WS- 3, WS-5, WS-12, and WS-23.

[0239] Most preferably, the liquid nicotine formulation comprises menthol and WS-23.

[0240] In embodiments in which the liquid nicotine formulation comprises a first cooling agent and a second cooling agent, the liquid nicotine formulation may have a first cooling agent content of greater than or equal to about 0.75 percent by weight, greater than or equal to about 1 percent by weight, greater than or equal to about 1.25 percent by weight, greater than or equal to about 1.5 percent by weight, or greater than or equal to about 1.75 percent by weight.

[0241] In embodiments in which the liquid nicotine formulation comprises a first cooling agent and a second cooling agent, the liquid nicotine formulation may have a first cooling agent content of less than or equal to about 6 percent by weight, less than or equal to about 5 percent by weight, less than or equal to about 4 percent by weight, less than or equal to about 3 percent by weight, or less than or equal to about 2.5 percent by weight.

[0242] In embodiments in which the liquid nicotine formulation comprises a first cooling agent and a second cooling agent, the liquid nicotine formulation may have a first cooling agent content P / 91070.W002

[0243] - 24 - of between about 0.75 percent by weight and about 6 percent by weight, between about 0.75 percent by weight and about 5 percent by weight, between about 0.75 percent by weight and about 4 percent by weight, between about 0.75 percent by weight and about 3 percent by weight, or between about 0.75 percent by weight and about 2.5 percent by weight.

[0244] In embodiments in which the liquid nicotine formulation comprises a first cooling agent and a second cooling agent, the liquid nicotine formulation may have a first cooling agent content of between about 1 percent by weight and about 6 percent by weight, between about 1 percent by weight and about 5 percent by weight, between about 1 percent by weight and about 4 percent by weight, between about 1 percent by weight and about 3 percent by weight, or between about 1 percent by weight and about 2.5 percent by weight.

[0245] In embodiments in which the liquid nicotine formulation comprises a first cooling agent and a second cooling agent, the liquid nicotine formulation may have a first cooling agent content of between about 1.25 percent by weight and about 6 percent by weight, between about 1.25 percent by weight and about 5 percent by weight, between about 1.25 percent by weight and about 4 percent by weight, between about 1.25 percent by weight and about 3 percent by weight, or between about 1.25 percent by weight and about 2.5 percent by weight.

[0246] In embodiments in which the liquid nicotine formulation comprises a first cooling agent and a second cooling agent, the liquid nicotine formulation may have a first cooling agent content of between about 1.5 percent by weight and about 6 percent by weight, between about 1.5 percent by weight and about 5 percent by weight, between about 1 .5 percent by weight and about 4 percent by weight, between about 1.5 percent by weight and about 3 percent by weight, or between about 1.5 percent by weight and about 2.5 percent by weight.

[0247] In embodiments in which the liquid nicotine formulation comprises a first cooling agent and a second cooling agent, the liquid nicotine formulation may have a first cooling agent content of between about 1.75 percent by weight and about 6 percent by weight, between about 1.75 percent by weight and about 5 percent by weight, between about 1.75 percent by weight and about 4 percent by weight, between about 1.75 percent by weight and about 3 percent by weight, or between about 1.75 percent by weight and about 2.5 percent by weight.

[0248] In embodiments in which the liquid nicotine formulation comprises a first cooling agent and a second cooling agent, the liquid nicotine formulation may have a second cooling agent content of greater than or equal to about 0.25 percent by weight, greater than or equal to about 0.3 percent by weight, greater than or equal to about 0.35 percent by weight, greater than or equal to about 0.4 percent by weight, or greater than or equal to about 0.45 percent by weight

[0249] In embodiments in which the liquid nicotine formulation comprises a first cooling agent and a second cooling agent, the liquid nicotine formulation may have a second cooling agent content of less than or equal to about 2 percent by weight, less than or equal to about 1.75 percent P / 91070.W002

[0250] - 25 - by weight, less than or equal to about 1.5 percent by weight, less than or equal to about 1.25 percent by weight, or less than or equal to about 1 percent by weight.

[0251] In embodiments in which the liquid nicotine formulation comprises a first cooling agent and a second cooling agent, the liquid nicotine formulation may have a second cooling agent content of between about 0.25 percent by weight and about 2 percent by weight, between about 0.25 percent by weight and about 1 .75 percent by weight, between about 0.25 percent by weight and about 1.5 percent by weight, between about 0.25 percent by weight and about 1.25 percent by weight, or between about 0.25 percent by weight and about 1 percent by weight.

[0252] In embodiments in which the liquid nicotine formulation comprises a first cooling agent and a second cooling agent, the liquid nicotine formulation may have a second cooling agent content of between about 0.3 percent by weight and about 2 percent by weight, between about 0.3 percent by weight and about 1.75 percent by weight, between about 0.3 percent by weight and about 1.5 percent by weight, between about 0.3 percent by weight and about 1.25 percent by weight, or between about 0.3 percent by weight and about 1 percent by weight.

[0253] In embodiments in which the liquid nicotine formulation comprises a first cooling agent and a second cooling agent, the liquid nicotine formulation may have a second cooling agent content of between about 0.35 percent by weight and about 2 percent by weight, between about 0.35 percent by weight and about 1 .75 percent by weight, between about 0.35 percent by weight and about 1.5 percent by weight, between about 0.35 percent by weight and about 1.25 percent by weight, or between about 0.35 percent by weight and about 1 percent by weight.

[0254] In embodiments in which the liquid nicotine formulation comprises a first cooling agent and a second cooling agent, the liquid nicotine formulation may have a second cooling agent content of between about 0.4 percent by weight and about 2 percent by weight, between about 0.4 percent by weight and about 1.75 percent by weight, between about 0.4 percent by weight and about 1.5 percent by weight, between about 0.4 percent by weight and about 1.25 percent by weight, or between about 0.4 percent by weight and about 1 percent by weight.

[0255] In embodiments in which the liquid nicotine formulation comprises a first cooling agent and a second cooling agent, the liquid nicotine formulation may have a second cooling agent content of between about 0.45 percent by weight and about 2 percent by weight, between about 0.45 percent by weight and about 1 .75 percent by weight, between about 0.45 percent by weight and about 1.5 percent by weight, between about 0.45 percent by weight and about 1.25 percent by weight, or between about 0.45 percent by weight and about 1 percent by weight.

[0256] In embodiments in which the liquid nicotine formulation comprises a first cooling agent and a second cooling agent, the ratio of the weight percent first cooling agent content to the weight percent second cooling agent content of the liquid nicotine formulation may be greater than or P / 91070.W002

[0257] - 26 - equal to about 1 :1 , greater than or equal to about 3:2, greater than or equal to about 2: 1 , or greater than or equal to about 5:2.

[0258] In embodiments in which the liquid nicotine formulation comprises a first cooling agent and a second cooling agent, the ratio of the weight percent first cooling agent content to the weight percent second cooling agent content of the liquid nicotine formulation may be less than or equal to about 11 :2, less than or equal to about 5:1 , less than or equal to about 9:2, or less than or equal to about 4:1.

[0259] In embodiments in which the liquid nicotine formulation comprises a first cooling agent and a second cooling agent, the ratio of the weight percent first cooling agent content to the weight percent second cooling agent content of the liquid nicotine formulation may be between about 1 :1 and about 11 :2, between about 1 :1 and about 5:1 , between about 1 :1 and about 9:2, or between about 1 : 1 and about 4: 1.

[0260] In embodiments in which the liquid nicotine formulation comprises a first cooling agent and a second cooling agent, the ratio of the weight percent first cooling agent content to the weight percent second cooling agent content of the liquid nicotine formulation may be between about 3:2 and about 11 :2, between about 3:2 and about 5:1 , between about 3:2 and about 9:2, or between about 3:2 and about 4: 1.

[0261] In embodiments in which the liquid nicotine formulation comprises a first cooling agent and a second cooling agent, the ratio of the weight percent first cooling agent content to the weight percent second cooling agent content of the liquid nicotine formulation may be between about 2:1 and about 11 :2, between about 2: 1 and about 5: 1 , between about 2:1 and about 9:2, or between about 2: 1 and about 4: 1.

[0262] In embodiments in which the liquid nicotine formulation comprises a first cooling agent and a second cooling agent, the ratio of the weight percent first cooling agent content to the weight percent second cooling agent content of the liquid nicotine formulation may be between about 5:2 and about 11 :2, between about 5:2 and about 5:1 , between about 5:2 and about 9:2, or between about 5:2 and about 4: 1.

[0263] Preferably, the liquid nicotine formulation comprises one or more non-cooling flavourants.

[0264] As used herein, the term “non-cooling flavourant” describes a flavourant that is not a cooling agent. That is, as used herein, the term “non-cooling flavourant” describes a flavourant that is not a cold receptor agonist.

[0265] Suitable non-cooling flavourants include, but are not limited to, ethyl vanillin, and vanillin.

[0266] The liquid nicotine formulation may comprise one or more natural non-cooling flavourants, or one or more synthetic non-cooling flavourants, or a combination of one or more natural noncooling flavourants and one or more synthetic non-cooling flavourants. P / 91070.W002

[0267] - 27 -

[0268] The liquid nicotine formulation may have a non-cooling flavourant content of greater than or equal to about 0.5 percent by weight, greater than or equal to about 1 percent by weight, greater than or equal to about 2 percent by weight, or greater than or equal to about 3 percent by weight.

[0269] The liquid nicotine formulation may have a non-cooling flavourant content of less than or equal to about 15 percent by weight, less than or equal to about 14 percent by weight, less than or equal to about 13 percent by weight, or less than or equal to about 12 percent by weight.

[0270] The liquid nicotine formulation may have a non-cooling flavourant content of between about 0.5 percent by weight and about 15 percent by weight, between about 0.5 percent by weight and about 14 percent by weight, between about 0.5 percent by weight and about 13 percent by weight, or between about 0.5 percent by weight and about 12 percent by weight.

[0271] The liquid nicotine formulation may have a non-cooling flavourant content of between about 1 percent by weight and about 15 percent by weight, between about 1 percent by weight and about 14 percent by weight, between about 1 percent by weight and about 13 percent by weight, or between about 1 percent by weight and about 12 percent by weight.

[0272] The liquid nicotine formulation may have a non-cooling flavourant content of between about 2 percent by weight and about 15 percent by weight, between about 2 percent by weight and about 14 percent by weight, between about 2 percent by weight and about 13 percent by weight, or between about 2 percent by weight and about 12 percent by weight.

[0273] The liquid nicotine formulation may have a non-cooling flavourant content of between about 3 percent by weight and about 15 percent by weight, between about 3 percent by weight and about 14 percent by weight, between about 3 percent by weight and about 13 percent by weight, or between about 3 percent by weight and about 12 percent by weight.

[0274] Preferably, the liquid nicotine formulation has a non-cooling flavourant content of between about 1 percent by weight and about 15 percent by weight, or between about 3 percent by weight and about 12 percent by weight.

[0275] The liquid nicotine formulation may be a non-aqueous liquid nicotine formulation.

[0276] As used herein, the term “non-aqueous liquid nicotine formulation” describes a liquid nicotine formulation having a water content of less than 1 percent by weight.

[0277] The liquid nicotine formulation may comprise water.

[0278] In embodiments in which the liquid nicotine formulation comprises water, the water may advantageously help to dissolve and stabilise polar components and ionic components of the liquid nicotine formulation.

[0279] In embodiments in which the liquid nicotine formulation comprises water, the liquid nicotine formulation may have a water content of greater than or equal to about 1 percent by weight, greater than or equal to about 2 percent by weight, or greater than or equal to about 3 percent by weight. P / 91070.W002

[0280] - 28 - ln embodiments in which the liquid nicotine formulation comprises water, the liquid nicotine formulation may have a water content of less than or equal to about 10 percent by weight, less than or equal to about 8 percent by weight, or less than about 6 percent by weight.

[0281] In embodiments in which the liquid nicotine formulation comprises water, the liquid nicotine formulation may have a water content of between about 1 percent by weight and about 10 percent by weight, between about 1 percent by weight and about 8 percent by weight, or between about

[0282] 1 percent by weight and about 6 percent by weight.

[0283] In embodiments in which the liquid nicotine formulation comprises water, the liquid nicotine formulation may have a water content of between about 2 percent by weight and about 10 percent by weight, between about 2 percent by weight and about 8 percent by weight, or between about

[0284] 2 percent by weight and about 6 percent by weight.

[0285] In embodiments in which the liquid nicotine formulation comprises water, the liquid nicotine formulation may have a water content of between about 3 percent by weight and about 10 percent by weight, between about 3 percent by weight and about 8 percent by weight, or between about

[0286] 3 percent by weight and about 6 percent by weight.

[0287] The pH of the liquid nicotine formulation may be measured by mixing the liquid nicotine formulation with a quantity of water and measuring the pH of the resulting solution with a pH meter. Unless stated otherwise, pH values of the liquid nicotine formulation recited herein are the pH of a 1 :3 ratio by volume of the liquid nicotine formulation to water.

[0288] The liquid nicotine formulation may have a pH of greater than or equal to about 3.5, greater than or equal to about 4, greater than or equal to about 4.5, or greater than or equal to about 5.

[0289] The liquid nicotine formulation may have a pH of less than or equal to about 7.5, less than or equal to about 7, less than or equal to about 6.5, or less than or equal to about 6.

[0290] The liquid nicotine formulation may have a pH of between about 3.5 and about 7.5, between about 3.5 and about 7, between about 3.5 and about 6.5, or between about 3.5 and about 6.

[0291] The liquid nicotine formulation may have a pH of between about 4 and about 7.5, between about 4 and about 7, between about 4 and about 6.5, or between about 4 and about 6.

[0292] The liquid nicotine formulation may have a pH of between about 4.5 and about 7.5, between about 4.5 and about 7, between about 4.5 and about 6.5, or between about 4.5 and about 6.

[0293] The liquid nicotine formulation may have a pH of between about 5 and about 7.5, between about 5 and about 7, between about 5 and about 6.5, or between about 5 and about 6.

[0294] According to the second aspect of the invention there is provided a cartridge for an aerosol-generating system, the cartridge comprising: a liquid storage portion comprising a liquid nicotine formulation according to the first aspect of the invention; and an atomiser in fluid P / 91070.W002

[0295] - 29 - communication with the liquid storage portion, wherein the atomiser is configured to vaporise the liquid nicotine formulation to generate an aerosol.

[0296] The atomiser may be a thermal atomiser.

[0297] As used herein with reference to the invention, the term “thermal atomiser” describes an atomiser that is configured to heat the liquid nicotine formulation to generate an aerosol.

[0298] Cartridge according to the second aspect of the invention may comprise any suitable type of thermal atomiser.

[0299] The thermal atomiser may comprise a heater. The thermal atomiser may comprise an electric heater. For example, the thermal atomiser may comprise an electric heater comprising a resistive heating element or an inductive heating element.

[0300] The heater may comprise a heater coil.

[0301] The heater may comprise a fluid permeable heating element comprising an electrically conductive mesh.

[0302] The thermal atomiser may comprise a heater and a transport element configured to transport liquid nicotine formulation to the heater.

[0303] The transport element may comprise a capillary wick.

[0304] The atomiser may be a non-thermal atomiser.

[0305] As used herein with reference to the invention, the term “non-thermal atomiser” describes an atomiser that is configured to generate an aerosol from the liquid nicotine formulation by means other than heating.

[0306] Cartridges according to the second aspect of the invention may comprise any suitable type of non-thermal atomiser.

[0307] For example, the non-thermal atomiser may be an impinging jet atomiser, an ultrasonic atomiser or a vibrating mesh atomiser.

[0308] According to the third aspect of the invention there is provided an aerosol-generating system comprising a cartridge according to the second aspect of the invention; and an aerosolgenerating device configured to be removably coupled to the cartridge.

[0309] The aerosol-generating system may comprise: a consumable cartridge according to the second aspect of the invention; and a reusable aerosol-generating device configured to be removably coupled to the cartridge.

[0310] The aerosol-generating device may be configured to be removably coupled to the cartridge using any suitable means. For example, the aerosol-generating device may be configured to be removably coupled to the cartridge via a snap-fit connection or corresponding screw threads. P / 91070.W002

[0311] - 30 -

[0312] The aerosol-generating system may comprise: a cartridge according to the second aspect of the invention; and an aerosol-generating device comprising a housing defining a device cavity configured to receive at least a portion of the cartridge.

[0313] The aerosol-generating device may comprise a power supply and control electronics.

[0314] The aerosol-generating device may comprise a battery and control electronics.

[0315] The power supply may be configured to supply power to the atomiser when the aerosolgenerating device is coupled to the cartridge. For example, the power supply may be configured to resistively heat the atomiser.

[0316] The aerosol-generating device may comprise an inductor. For example, the aerosolgenerating device may comprise an induction coil.

[0317] Below, there is provided a non-exhaustive list of non-limiting examples. Any one or more of the features of these examples may be combined with any one or more features of another example, embodiment, or aspect described herein.

[0318] EX1 : A liquid nicotine formulation for use in an aerosol-generating system, the liquid nicotine formulation comprising: nicotine; a liquid carrier; one or more monocarboxylic acids, one or more high-intensity sweeteners; and one or more cooling agents.

[0319] EX2: A liquid nicotine formulation according to example EX1 wherein the liquid nicotine formulation has a nicotine content of between about 0.1 percent by weight and about 10 percent by weight.

[0320] EX3: A liquid nicotine formulation according to example EX1 or EX2 wherein the liquid nicotine formulation has a nicotine content of between about 0.2 percent by weight and about 5 percent by weight.

[0321] EX4: A liquid nicotine formulation according to any one of examples EX1 to EX3 wherein the liquid nicotine formulation has a nicotine content of between about 0.6 percent by weight and about 4 percent by weight.

[0322] EX5 A liquid nicotine formulation according to any one of examples EX1 to EX4 wherein the liquid nicotine formulation has a nicotine content of about 0.8 percent by weight, about 1.6 percent by weight, about 1.8 percent by weight, or about 3.5 percent by weight.

[0323] EX6: A liquid nicotine formulation according to any one of examples EX1 to EX5 wherein the liquid carrier comprises glycerine and propylene glycol.

[0324] EX7: A liquid nicotine formulation according to any one of examples EX1 to EX6 wherein the liquid carrier comprises vegetable glycerine and propylene glycol.

[0325] EX8: A liquid nicotine formulation according to example EX6 or EX7 wherein the ratio of the weight percent propylene glycol content to the weight percent glycerine content of the liquid nicotine formulation is between about 3:5 and about 2:1. P / 91070.W002

[0326] - 31 -

[0327] EX9: A liquid nicotine formulation according to any one of examples EX6 to EX8 wherein the ratio of the weight percent propylene glycol content to the weight percent glycerine content of the liquid nicotine formulation is between about 4:5 and about 9:5.

[0328] EX10: A liquid nicotine formulation according to any one of examples EX6 to EX9 wherein the ratio of the weight percent propylene glycol content to the weight percent glycerine content of the liquid nicotine formulation is between about 1 :1 and about 8:5.

[0329] EX11 : A liquid nicotine formulation according to any one of examples EX6 to EX10 wherein the ratio of the weight percent propylene glycol content to the weight percent glycerine content of the liquid nicotine formulation is between about 6:5 and about 7:5.

[0330] EX12: A liquid nicotine formulation according to any one of examples EX6 to EX11 wherein the ratio of the weight percent propylene glycol content to the weight percent glycerine content of the liquid nicotine formulation is about 5:4.

[0331] EX13: A liquid nicotine formulation according to any one of examples EX6 to EX12 wherein the liquid nicotine formulation has a propylene glycol content of between about 20 percent by weight and about 80 percent by weight.

[0332] EX14: A liquid nicotine formulation according to any one of examples EX6 to EX13 wherein the liquid nicotine formulation has a propylene glycol content of between about 40 percent by weight and about 60 percent by weight.

[0333] EX15: A liquid nicotine formulation according to any one of examples EX6 to EX14 wherein the liquid nicotine formulation has a propylene glycol content of between about 45 percent by weight and about 55 percent by weight.

[0334] EX16: A liquid nicotine formulation according to any one of examples EX6 to EX15 wherein the liquid nicotine formulation has a glycerine content of between about 20 percent by weight and about 80 percent by weight.

[0335] EX17: A liquid nicotine formulation according to any one of examples EX6 to EX16 wherein the liquid nicotine formulation has a glycerine content of between about 30 percent by weight and about 60 percent by weight.

[0336] EX18: A liquid nicotine formulation according to any one of examples EX6 to EX17 wherein the liquid nicotine formulation has a glycerine content of between about 35 percent by weight and about 45 percent by weight.

[0337] EX19: A liquid nicotine formulation according to any one of examples EX1 to EX18 wherein the liquid carrier is a non-aqueous liquid carrier.

[0338] EX20: A liquid nicotine formulation according to any one of examples EX1 to EX19 wherein the liquid nicotine formulation is a non-aqueous liquid nicotine formulation. P / 91070.W002

[0339] - 32 -

[0340] EX21 : A liquid nicotine formulation according to any one of examples EX1 to EX20 wherein the liquid nicotine formulation comprises one or more monocarboxylic acids selected from acetic acid, benzoic acid, lactic acid, levulinic acid, and salicyclic acid.

[0341] EX22: A liquid nicotine formulation according to any one of examples EX1 to EX21 wherein the liquid nicotine formulation comprises one or more monocarboxylic acids selected from acetic acid, benzoic acid, lactic acid, and levulinic acid.

[0342] EX23: A liquid nicotine formulation according to any one of examples EX1 to EX22 wherein liquid nicotine formulation comprises one or more monocarboxylic acids selected from benzoic acid and lactic acid.

[0343] EX24: A liquid nicotine formulation according to any one of examples EX1 to EX23 wherein the liquid nicotine formulation comprises benzoic acid and lactic acid.

[0344] EX25: A liquid nicotine formulation according to any one of examples EX1 to EX23 wherein the liquid nicotine formulation comprises benzoic acid.

[0345] EX26: A liquid nicotine formulation according to example EX24 or EX25 wherein the molar ratio of benzoic acid to nicotine in the liquid nicotine formulation is between about 0.2:1 and about 1 :1.

[0346] EX27: A liquid nicotine formulation according to any one of examples EX24 to EX26 wherein the molar ratio of benzoic acid to nicotine in the liquid nicotine formulation is between about 0.3: 1 and about 0.9:1.

[0347] EX28: A liquid nicotine formulation according to any one of examples EX24 to EX27 wherein the molar ratio of benzoic acid to nicotine in the liquid nicotine formulation is between about 0.4: 1 and about 0.8:1.

[0348] EX29: A liquid nicotine formulation according to any one of examples EX24 to EX28 wherein the molar ratio of benzoic acid to nicotine in the liquid nicotine formulation is between about 0.5: 1 and about 0.7:1.

[0349] EX30: A liquid nicotine formulation according to any one of examples EX1 to EX29 wherein the liquid nicotine formulation has a total carboxylic acid content of between about 0.1 percent by weight and about 7 percent by weight.

[0350] EX31 : A liquid nicotine formulation according to any one of examples EX1 to EX30 wherein the liquid nicotine formulation has a total carboxylic acid content of between about 0.2 percent by weight and about 6 percent by weight.

[0351] EX32: A liquid nicotine formulation according to any one of examples EX1 to EX31 wherein the liquid nicotine formulation has a total carboxylic acid content of between about 0.3 percent by weight and about 5 percent by weight. P / 91070.W002

[0352] - 33 -

[0353] EX33: A liquid nicotine formulation according to any one of examples EX1 to EX32 wherein the liquid nicotine formulation has a total carboxylic acid content of between about 0.4 percent by weight and about 4 percent by weight.

[0354] EX34: A liquid nicotine formulation according to any one of examples EX1 to EX33 wherein the liquid nicotine formulation has a total carboxylic acid content of between about 0.5 percent by weight and about 3 percent by weight.

[0355] EX35: A liquid nicotine formulation according to any one of examples EX1 to EX34 wherein the liquid nicotine formulation has a total high-intensity sweetener content of between about 0.01 percent by weight and about 2 percent by weight.

[0356] EX36: A liquid nicotine formulation according to any one of examples EX1 to EX35 wherein the liquid nicotine formulation has a total high-intensity sweetener content of between about 0.02 percent by weight and about 1.5 percent by weight.

[0357] EX37: A liquid nicotine formulation according to any one of examples EX1 to EX36 wherein the liquid nicotine formulation has a total high-intensity sweetener content of between about 0.03 percent by weight and about 1 percent by weight.

[0358] EX38: A liquid nicotine formulation according to any one of examples EX1 to EX37 wherein the liquid nicotine formulation has a total high-intensity sweetener content of between about 0.04 percent by weight and about 0.75 percent by weight.

[0359] EX39: A liquid nicotine formulation according to any one of examples EX1 to EX38 wherein the liquid nicotine formulation has a total high-intensity sweetener content of between about 0.05 percent by weight and about 0.5 percent by weight.

[0360] EX40: A liquid nicotine formulation according to any one of examples EX1 to EX39 wherein the ratio of the weight percent total high-intensity sweetener content to the weight percent nicotine content of the liquid nicotine formulation is between about 1 :200 and about 1 :1.

[0361] EX41 : A liquid nicotine formulation according to any one of examples EX1 to EX40 wherein the ratio of the weight percent total high-intensity sweetener content to the weight percent nicotine content of the liquid nicotine formulation is between about 1 :160 and about 1 :2.

[0362] EX42: A liquid nicotine formulation according to any one of examples EX1 to EX41 wherein the ratio of the weight percent total high-intensity sweetener content to the weight percent nicotine content of the liquid nicotine formulation is between about 1 :120 and about 1 :4.

[0363] EX43: A liquid nicotine formulation according to any one of examples EX1 to EX42 wherein the ratio of the weight percent total high-intensity sweetener content to the weight percent nicotine content of the liquid nicotine formulation is between about 1 :80 and about 1 :10.

[0364] EX44: A liquid nicotine formulation according to any one of examples EX1 to EX43 wherein the liquid nicotine formulation comprises one or more high-intensity sweeteners selected P / 91070.W002

[0365] - 34 - from advantame, acesulfame potassium, aspartame, cyclamates, glycyrrhizin, mogrosides, neotame, saccharin, steviol glycosides, and sucralose.

[0366] EX45: A liquid nicotine formulation according to any one of examples EX1 to EX44 wherein the liquid nicotine formulation comprises one or more high-intensity sweeteners selected from advantame, acesulfame potassium, cyclamates, glycyrrhizin, mogrosides, neotame, saccharin, steviol glycosides, and sucralose.

[0367] EX46: A liquid nicotine formulation any one of examples EX1 to EX45 wherein the liquid nicotine formulation comprises neotame.

[0368] EX47: A liquid nicotine formulation according to example EX46 wherein the liquid nicotine formulation has a neotame content of between about 0.01 percent by weight and about 1 percent by weight.

[0369] EX48: A liquid nicotine formulation according to example E46 or EX47 wherein the liquid nicotine formulation has a neotame content of between about 0.02 percent by weight and about 0.8 percent by weight.

[0370] EX49: A liquid nicotine formulation according to any one of examples EX46 to EX48 wherein the liquid nicotine formulation has a neotame content of between about 0.03 percent by weight and about 0.6 percent by weight.

[0371] EX50: A liquid nicotine formulation according to any one of examples EX46 to EX49 wherein the liquid nicotine formulation has a neotame content of between about 0.04 percent by weight and about 0.5 percent by weight.

[0372] EX51 : A liquid nicotine formulation according to any one of examples EX46 to EX50 wherein the liquid nicotine formulation has a neotame content of between about 0.05 percent by weight and about 0.4 percent by weight.

[0373] EX52: A liquid nicotine formulation according to any one of examples EX46 to EX51 wherein the ratio of the neotame content to the weight percent nicotine content of the liquid nicotine formulation is between about 1 :200 and about 1 :1.

[0374] EX53: A liquid nicotine formulation according to any one of examples EX46 to EX52 wherein the ratio of the weight percent neotame content to the weight percent nicotine content of the liquid nicotine formulation is between about 1 :160 and about 1 :2.

[0375] EX54: A liquid nicotine formulation according to any one of examples EX46 to EX53 wherein the ratio of the weight percent neotame content to the weight percent nicotine content of the liquid nicotine formulation is between about 1 :120 and about 1 :4.

[0376] EX55: A liquid nicotine formulation according to any one of examples EX46 to EX54 wherein the ratio of the weight percent neotame content to the weight percent nicotine content of the liquid nicotine formulation is between about 1 :80 and about 1 :10. P / 91070.W002

[0377] - 35 -

[0378] EX56: A liquid nicotine formulation according to any one of examples EX1 to EX55 wherein the liquid nicotine formulation has a total cooling agent content of between about

[0379] 1 percent by weight and about 8 percent by weight.

[0380] EX57: A liquid nicotine formulation according to any one of examples EX1 to EX56 wherein the liquid nicotine formulation has a total cooling agent content of between about 1.25 percent by weight and about 6 percent by weight.

[0381] EX58: A liquid nicotine formulation according to any one of examples EX1 to EX57 wherein the liquid nicotine formulation has a total cooling agent content of between about 1.5 percent by weight and about 6 percent by weight.

[0382] EX59: A liquid nicotine formulation according to any one of examples EX1 to EX58 wherein the liquid nicotine formulation has a total cooling agent content of between about 1.5 percent by weight and about 5 percent by weight.

[0383] EX60: A liquid nicotine formulation according to any one of examples EX1 to EX59 wherein the liquid nicotine formulation has a total cooling agent content of between about 1.75 percent by weight and about 4 percent by weight.

[0384] EX61 : A liquid nicotine formulation according to any one of examples EX1 to EX60 wherein the liquid nicotine formulation has a total cooling agent content of between about

[0385] 2 percent by weight and about 4 percent by weight.

[0386] EX62: A liquid nicotine formulation according to any one of examples EX1 to EX61 wherein the liquid nicotine formulation has a total cooling agent content of between about 2 percent by weight and about 3 percent by weight.

[0387] EX63: A liquid nicotine formulation according to any one of examples EX1 to EX62 wherein the ratio of the weight percent total cooling agent content to the weight percent nicotine content of the liquid nicotine formulation is between about 1:4 and about 8:1.

[0388] EX64: A liquid nicotine formulation according to any one of examples EX1 to EX63 wherein the ratio of the weight percent total cooling agent content to the weight percent nicotine content of the liquid nicotine formulation is between about 1 :3 and about 6:1.

[0389] EX65: A liquid nicotine formulation according to any one of examples EX1 to EX64 wherein the ratio of the weight percent total cooling agent content to the weight percent nicotine content of the liquid nicotine formulation is between about 1 :2 and about 5:1.

[0390] EX66: A liquid nicotine formulation according to any one of examples EX1 to EX65 wherein the ratio of the weight percent total cooling agent content to the weight percent nicotine content of the liquid nicotine formulation is between about 2:3 and about 4: 1.

[0391] EX67: A liquid nicotine formulation according to any one of examples EX1 to EX66 wherein liquid nicotine formulation comprises one or more monoterpene or monoterpenoid cooling agents. P / 91070.W002

[0392] - 36 -

[0393] EX68: A liquid nicotine formulation according to any one of examples EX1 to EX67 wherein the liquid nicotine formulation comprises one or more monoterpene or monoterpenoid cooling agents selected from L-carvone, isomenthone, isomenthyl acetate, menthol, menthone, menthyl acetate, menthyl lactate, and menthyl isovalerate.

[0394] EX69: A liquid nicotine formulation according to any one of examples EX1 to EX68 wherein the liquid nicotine formulation comprises one or more WS (Wilkinson Sword) cooling agents.

[0395] EX70: A liquid nicotine formulation according to any one of examples EX1 to EX69 wherein the liquid nicotine formulation comprise one or more WS (Wilkinson Sword) cooling agents selected from WS-3, WS-5, WS-12, and WS-23.

[0396] EX71 : A liquid nicotine formulation according to any one of examples EX1 to EX70 wherein the liquid nicotine formulation comprises one or more cooling agents selected from isomenthone, isomenthyl acetate, isopulegone, L-carvone, menthol, menthone, menthyl acetate, menthyl lactate, menthyl isovalerate, WS-3, WS-5, WS-12, and WS-23.

[0397] EX72: A liquid nicotine formulation according to any one of examples EX1 to EX71 wherein the ratio of the weight percent total cooling agent content to the weight percent total high- intensity sweetener content of the liquid nicotine formulation is between about 25:1 and about 65:1.

[0398] EX73: A liquid nicotine formulation according to any one of examples EX1 to EX72 wherein the ratio of the weight percent total cooling agent content to the weight percent total high- intensity sweetener content of the liquid nicotine formulation is between about 30:1 and about 60:1.

[0399] EX74: A liquid nicotine formulation according to any one of examples EX1 to EX73 wherein the ratio of the weight percent total cooling agent content to the weight percent total high- intensity sweetener content of the liquid nicotine formulation is between about 35:1 and about 55:1.

[0400] EX75: A liquid nicotine formulation according to any one of examples EX1 to EX74 wherein the ratio of the weight percent total cooling agent content to the weight percent total high- intensity sweetener content of the liquid nicotine formulation is between about 40:1 and about 50:1.

[0401] EX76: A liquid nicotine formulation according to any one of examples EX1 to EX75 wherein the liquid nicotine formulation comprises a first cooling agent and a second cooling agent.

[0402] EX77: A liquid nicotine formulation according to example EX76 wherein the first cooling agent is a monoterpene or monoterpenoid cooling agent and the second cooling agent is a WS cooling agent. P / 91070.W002

[0403] - 37 -

[0404] EX78: A liquid nicotine formulation according to example EX76 or EX77 wherein the liquid nicotine formulation comprises: a first cooling agent selected from isomenthone, isomenthyl acetate, isopulegone, L-carvone, menthol, menthone, menthyl acetate, menthyl lactate, and menthyl isovalerate; and a second cooling agent selected from WS-3, WS-5, WS-12, and WS-23.

[0405] EX79: A liquid nicotine formulation according to any one of examples EX76 to EX78 wherein the liquid nicotine formulation has a first cooling agent content of between about 0.75 weight percent and about 6 weight percent.

[0406] EX80: A liquid nicotine formulation according to any one of examples EX76 to EX79 wherein the liquid nicotine formulation has a first cooling agent content of between about 1.25 weight percent and about 4 weight percent.

[0407] EX81 : A liquid nicotine formulation according to any one of examples EX76 to EX80 wherein the liquid nicotine formulation has a first cooling agent content of between about 1.75 weight percent and about 2.5 weight percent.

[0408] EX82: A liquid nicotine formulation according to any one of examples EX76 to EX81 wherein the liquid nicotine formulation has a second cooling agent content of between about 0.25 weight percent and about 2 weight percent.

[0409] EX83: A liquid nicotine formulation according to any one of examples EX76 to EX82 wherein the liquid nicotine formulation has a second cooling agent content of between about 0.35 weight percent and about 1.5 weight percent.

[0410] EX84: A liquid nicotine formulation according to any one of examples EX76 to EX83 wherein the liquid nicotine formulation has a second cooling agent content of between about 0.45 weight percent and about 1 weight percent.

[0411] EX85: A liquid nicotine formulation according to any one of examples EX76 to EX84 wherein the ratio of the weight percent first cooling agent content to the weight percent second cooling agent content of the liquid nicotine formulation is between about 1 :1 and about 11 :2.

[0412] EX86: A liquid nicotine formulation according to any one of examples EX76 to EX85 wherein the ratio of the weight percent first cooling agent content to the weight percent second cooling agent content of the liquid nicotine formulation is between about 3:2 and about 5:1.

[0413] EX87: A liquid nicotine formulation according to any one of examples EX76 to EX86 wherein the ratio of the weight percent first cooling agent content to the weight percent second cooling agent content of the liquid nicotine formulation is between about 2:1 and about 9:2.

[0414] EX88: A liquid nicotine formulation according to any one of examples EX76 to EX87 wherein the ratio of the weight percent first cooling agent content to the weight percent second cooling agent content of the liquid nicotine formulation is between about 5:2 and about 4:1.

[0415] EX89: A liquid nicotine formulation according to any one of examples EX76 to EX88 wherein the liquid nicotine formulation comprises menthol and WS-23. P / 91070.W002

[0416] - 38 -

[0417] EX90: A liquid nicotine formulation according to any one of examples EX1 to EX89 wherein the liquid nicotine formulation comprises one or more non-cooling flavourants.

[0418] EX91 : A liquid nicotine formulation according to example EX90 wherein the liquid nicotine formulation has a non-cooling flavourant content of between about 1 percent by weight and about 15 percent by weight.

[0419] EX92: A liquid nicotine formulation according to example EX90 or EX91 wherein the liquid nicotine formulation has a non-cooling flavourant content of between about 3 percent by weight and about 12 percent by weight.

[0420] EX93: A cartridge for an aerosol-generating system, the cartridge comprising: a liquid storage portion comprising a liquid nicotine formulation according to any one of examples EX1 to EX92; and an atomiser in fluid communication with the liquid storage portion, wherein the atomiser is configured to vaporise the liquid nicotine formulation to generate an aerosol.

[0421] EX94: An aerosol-generating system comprising a cartridge according to example EX93; and an aerosol-generating device configured to be removably coupled to the cartridge.

[0422] Liquid nicotine formulations according to the first aspect of the invention may have the compositions shown in Examples A to C:

[0423] Preferred liquid nicotine formulations according to the first aspect of the invention may have the compositions shown in Examples D to F: P / 91070.W002

[0424] - 39 -

[0425] Particularly preferred liquid nicotine formulations according to the first aspect of the invention may have the compositions shown in Examples G to I:

Claims

1. P / 91070.W002- 40 -CLAIMS1. A liquid nicotine formulation for use in an aerosol-generating system, the liquid nicotine formulation comprising: nicotine; a liquid carrier; one or more monocarboxylic acids, one or more high-intensity sweeteners; and one or more cooling agents, wherein a ratio of the weight percent total cooling agent content to the weight percent total high-intensity sweetener content of the liquid nicotine formulation is between about 30:1 and about 60:1.2 A liquid nicotine formulation according to any claim 1 wherein the one or more cooling agents are selected from: isomenthone; isomenthyl acetate; isopulegone; L-carvone; menthol; menthone; menthyl acetate; menthyl lactate; menthyl isovalerate; WS-3; WS-5; WS-12; and WS- 23.

3. A liquid nicotine formulation according to claim 1 or 2 having a total cooling agent content of between about 1.5 percent by weight and about 6 percent by weight.

4. A liquid nicotine formulation according to any one of claims 1 to 3 comprising: a first cooling agent selected from: isomenthone; isomenthyl acetate; isopulegone; L- carvone; menthol; menthone; menthyl acetate; menthyl lactate; and menthyl isovalerate; and a second cooling agent selected from WS-3; WS-5; WS-12; and WS-23.

5. A liquid nicotine formulation according to claim 4 having a first cooling agent content of between about 1 .25 percent by weight and about 4 percent by weight and a second cooling agent content of between about 0.35 percent by weight and about 1 .5 percent by weight.

6. A liquid nicotine formulation according to claim 4 or 5 comprising menthol and WS-23.

7. A liquid nicotine formulation according to any one of claims 1 to 6 wherein the one or more high-intensity sweeteners are selected from: advantame; aspartame; acesulfame potassium; cyclamates; glycyrrhizin; mogrosides; neotame; saccharin; steviol glycosides; and sucralose.P / 91070.W002- 41 -8. A liquid nicotine formulation according to claim 7 comprising neotame.

9. A liquid nicotine formulation according to any one of claims 1 to 8 having a total high- intensity sweetener content of between about 0.03 percent by weight and about 1 percent by weight.

10. A liquid nicotine formulation according to any of claims 1 to 9 wherein the one or more monocarboxylic acids are selected from: benzoic acid; and lactic acid.

11. A liquid nicotine formulation according to any of claims 1 to 10 wherein the liquid carrier comprises glycerine and propylene glycol.

12. A liquid nicotine formulation according to any one of claims 1 to 11 , the liquid nicotine formulation comprising: nicotine; propylene glycol and glycerine; benzoic acid; neotame; menthol and WS-23; and optionally one or more non-cooling flavourants.

13. A liquid nicotine formulation according to any one of claims 1 to 12, the liquid nicotine formulation comprising: nicotine in an amount of between about 0.6 percent by weight and about 4 percent by weight; propylene glycol in an amount of between about 45 percent by weight and about 55 percent by weight; benzoic acid in an amount of between 0.5 percent by weight and about 3 percent by weight; glycerine in an amount of between about 35 percent by weight and about 45 percent by weight; neotame in an amount of between about 0.05 percent by weight and about 0.4 percent by weight; menthol in an amount of between about 0.75 percent by weight and about 2.5 percent by weight;P / 91070.W002- 42 -WS-23 in an amount of between about 0.45 percent by weight and about 1 percent by weight; and optionally one or more non-cooling flavourants in an amount of between about 3 percent by weight and about 12 percent by weight.

14. A cartridge for an aerosol-generating system, the cartridge comprising: a liquid storage portion comprising a liquid nicotine formulation according to any one of claims 1 to 13; and an atomiser in fluid communication with the liquid storage portion, wherein the atomiser is configured to vaporise the liquid nicotine formulation to generate an aerosol.

15. An aerosol-generating system comprising: a cartridge according to claim 14; and an aerosol-generating device configured to be removably coupled to the cartridge.

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