Chelating mixtures

Abstract

The present invention relates to a mixture, blend or combination, comprising at least three chosen from the following compounds: (A) a pyrone derivative, (B) a tropolone derivative, (C) a phenylpropanoid, (D) a monoterpene or monoterpenoid, (E) an aromatic acid or salt, (F) a dipeptide, and (G) an alkanediol, and its use as chelating mixture.

Description

[0001] Eisenfiihr Speiser

[0002] Munich, 22 November 2024

[0003] Our Ref.: SM 7028-01 WO SOE / TWS

[0004] Applicant: Symrise AG

[0005] Serial Number: New Application

[0006] Symrise AG

[0007] MuhlenfeldstraBe 1 , 37603 Holzminden,

[0008] Germany

[0009] Chelating mixtures

[0010] The present invention mainly relates to mixtures with chelating properties and their application in pharmaceutical, cosmetic, personal care, animal care or homecare formulations. More specifically, the present invention relates to a mixture comprising at least two or three chosen from the following compounds: (A) a pyrone derivative, (B) a 5 tropolone derivative, (C) a phenylpropanoid, (D) a monoterpene or monoterpenoid, (E) an aromatic acid or salt, (F) a dipeptide, and (G) an alkanediol, and its use as chelating mixture.

[0011] Chelating agents play a crucial role in various formulations, such as pharmaceuticals, cosmetics, personal care, animal care, and homecare products, for several important0 reasons.

[0012] Chelating agents, like EDTA (ethylenediaminetetraacetic acid), bind to metal ions (such as calcium, magnesium, iron, and copper) that might otherwise react with ingredients in the formulation. These metal ions can catalyze oxidation reactions, leading to degradation or discoloration of the product. By sequestering these metals, chelating agents help stabilize5 the formulation and extend the shelf life of cosmetics. Metal ions in cosmetic products can promote the growth of certain microorganisms, as they can be essential nutrients for microbial activity. Chelating agents deprive microbes of these essential metals, thereby enhancing the effectiveness of preservatives and helping to maintain the product's hygiene. lllll HI II By binding to metal ions that could otherwise deactivate active ingredients, chelating agents help maintain the potency of key ingredients, such as antioxidants or preservatives, ensuring that the product performs as intended throughout its lifespan. Chelating agents prevent metal-induced reactions that could cause undesirable physical changes in the product, such as changes in color, texture, or viscosity. This helps maintain the cosmetic's appealing appearance and smooth application properties. In products like shampoos or cleansers, chelating agents can neutralize the impact of hard water minerals (e.g., calcium or magnesium) that might reduce the effectiveness of surfactants, improving foaming action and rinse-off performance.

[0013] In summary, chelating agents in cosmetic formulations enhance stability, preserve product quality, and improve the overall effectiveness and appearance of the product by controlling unwanted interactions with metal ions.

[0014] However, there is no universal chelating agent that fits all needs I formulations, hence the industry continuously thrives to explore further compounds which exhibit effective chelating properties. Moreover, with the number of consumer reports on skin intolerances to cosmetics increasing, the ambition grows to reduce synthetic compounds, and in generally reduce the number of ingredients in a cosmetic product. It would thus be desirable to identify multifunctional agents providing both chelating and cosmetic effects. Desirably, the agents are at least partly natural and / or plant-based.

[0015] It is thus a main object of the present invention to provide new chelating agents as a replacement or partial replacement for existing chelating agents. An optional aim is to provide the chelating agents in the form of multifunctional compounds that combine the chelating capability with further functions that are of interest for pharmaceutical, cosmetic, personal care, and animal care or homecare formulations.

[0016] These objects are achieved by the present invention as specified in the appended claims. The invention itself, and its preferred variants, other objects and advantages, are however also apparent from the following detailed description in conjunction with the accompanying examples and figures. According to a first aspect of the present invention, a mixture comprises, or consists of, at least two or three of the following compounds:

[0017] (A) a pyrone derivative,

[0018] (B) a tropolone derivative,

[0019] (C) a phenylpropanoid,

[0020] (D) a monoterpene or monoterpenoid,

[0021] (E) an aromatic acid or salt,

[0022] (F) a dipeptide,

[0023] (G) an alkanediol.

[0024] The present invention is based on the inventors’ observation that a combination of two or three out of the aforementioned seven compounds A, B, C, D, E, F and G exhibit chelating properties. Advantageously, the effect is synergistic (as determined by the assays described herein). This means, the mixture of the invention is more effective than the sum of each respective compound alone. Therefore, the mixture is capable to function as a strong (synergistic) chelating mixture (system) alone or in conjunction with one or more further chelating agent(s) chemically distinct from the components A to G. Another advantage is that the mixtures of the invention are formed from compounds established on the cosmetic sector. They can thus be rapidly integrated in pharmaceutical, cosmetic, personal care, and animal care or homecare formulations. They not only impart cosmetically relevant properties, but have also proven to be well-tolerated for use in skin products. They are renewable or naturally occurring, and may thus be provided as mixtures free of synthetic compounds.

[0025] Any of compounds A to G is understood to respectively denote a single compound. However, this does not exclude the general possibility that mixtures of the invention may comprise one or more further compound(s) falling within the definition of one or more of compounds A to G. Moreover, any of components A to G may be provided by way of a mixture, such as a natural extract. For example, hinokitiol can be found in extracts of Hinoki cypress. Mixtures containing such extract would therefore comprise hinokitiol as compound B.

[0026] Compound A, preferably maltol, may be provided as pure substance, in diluted or dispersed form, or in the form of an extract such as a sugarcane ferment extract.

[0027] Compound B, preferably hinokitiol, may be provided as pure substance, in diluted or dispersed form, or in the form of an extract such as an extract of Hinoki cypress.

[0028] Compound C, preferably cinnamal, may be provided as pure substance, in diluted or dispersed form, or in the form of an extract such as cinnamomum cassia bark oil. Compound D may be provided as pure substance, in diluted or dispersed form, or in the form of an extract such as eucalyptus dives oil in the case of piperitone, or Litsea Cubeba oil or Lemongras oil cochin in the case of citral.

[0029] Compound E, an aromatic acid or salt, preferably anisic acid or a salt thereof, may be provided as pure substance, in diluted or dispersed form, or in the form of extract such as anis oil.

[0030] Compound F, a dipeptide, preferably carnosine, may be provided as pure substance, in diluted or dispersed form, or in the form of an extract. Although carnosine is a natural substance, it is primarily produced by synthesis.

[0031] Compound G, an alkanediol, preferably an 1 ,2-alkanediol, may be provided as pure substance, in diluted or dispersed form.

[0032] Moreover, the compounds chosen from A to G may be provided in the form of a (homogeneous) blend, a (heterogeneous) mixture, or as a combination in separate containers. The compounds may also be provided as a solution, for instance the compounds may be dissolved in a common solvent. A combination in separate containers is also referred to as a kit-type combination provided in separate containers. This means, compound A may be contained in a first container, compound B may be contained in a second container and compound C may be contained in a third container, etc.

[0033] Although the invention is not limited in this regard, it is preferred that all compounds in the mixtures of the invention occur in nature or are derived from renewable sources. This does not mean that the compounds are actually isolated from the nature, but they may also be synthetically derived as long as they occur naturally as such. Moreover, some compounds, for example, compounds A, B, C, D, E and G, may be of natural origin, whereas other compounds, for example compound F, the dipeptide, may be obtained by chemical synthesis.

[0034] In some embodiments, the mixture of the invention is a bio-mixture. The term “bio-mixture” means that some or all of components A to G are from bio-based sources. For example, the components A to G may be obtained from bioderived feedstock by fermentation, or from bio-based natural and renewable feedstock - such as biomass by catalytic synthesis as described in US 2019 / 0241491 A1 and US 2020 / 0189995 A1 for the component G. However, the present invention is not limited to a bio-mixture. It is rather envisaged that one, two, three or more, or even all of components A to G are derived from petrochemical or other fossil fuel sources by chemical synthesis. A mixture of bio-based and petrochemical components is also possible. It is also possible that all compounds included in the mixture occur naturally, whether the compounds of the mixture are actually of natural or synthetic origin.

[0035] The term “comprising” means that the named recitations are essential, and that additional recitations may be included. The term “consisting of’ signifies that the subject matter is closed-ended and only includes the recitations that are expressly recited. Whenever reference is made to “comprising” it is intended to cover both meanings as alternative embodiments. That is, the meaning can be either “comprising” or “consisting of’, unless the context dictates otherwise.

[0036] Compound A, a pyrone derivative, is an organic compound that is chemically based on, preferably includes, a pyrone structure, a six-membered ring containing both oxygen and carbon atoms, along with a carbonyl group within the ring. Preferred pyrone derivatives include a-Pyrone (2-pyrone) and y-Pyrone (4-pyrone). a-Pyrones are also known as 2H- pyran-2-one, and have the carbonyl group at the 2-position relative to the oxygen atom in the ring. y-Pyrones have the carbonyl group at the 4-position, making this structure 4H- pyran-4-one. Preferred examples of pyrone derivatives include coumarin, chromones, kojic acid (5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one), flavonoids, maltol, xanthones, 6- pentyl-2H-pyran-2-one, kojic acid derivatives (e.g., kojic dipalmitate), 2-ethyl-3 -hydroxy- 4H-pyran-4-one, 3-hydroxy-2-propylpyran-4-one, 3-hydroxy-2-propan-2-ylpyran-4-one, 2- acetyl-3-hydroxypyran-4-one, 2-ethyl-5-hydroxypyran-4-one, 3-hydroxy-2-(2-propen-l-y1 )- 4H-Pyran-4-one, 3-hydroxypyran-4-one, 2-hex-2-eny1-3-hydroxypyran-4-one, 3,5- dihydroxy-2-methy1 -4H-pyran-4-one (5-hydroxymaltol), 2-methy1 -4-oxo-4H-pyran-3-y1 isobutyrate (maltol isobutyrate), 2-methy1-3-(1-oxopropoxy)-4H-pyran-4-one (maltol propionate), 2-methy1 -4-oxo-4H-pyran-3-y1 butyrate (maltol butyrate), (2-methy1-4- oxopyran-3-y1) acetate, (2-ethy1-4-oxopyran-3 -y1) 2-methylpropanoate, 2-methy1-4-oxo- 4H-pyran-3-y1 2-hydroxybenzoate (salicylic acid maltol ester), 2-methy1-4-oxo-4H-pyran- 3-y1 lactate (maltol lactate), 2-methy1-4-oxo-4H-pyran-3-y1 , (Z)-(2-methy1-4-oxopyran-3- y1)-2-methylpent-2-enoate, (E)-(2-methy1-4-oxopyran-3-y1)-2-methylpent-2-enoate, and combinations thereof.

[0037] Preferably, the pyrone derivative is a 3-hydroxy-4-pyrone. It consists of a pyrone ring with a hydroxyl group attached at the 3rd position and a ketone group at the 4th position. Examples of 3-hydroxy-4-pyrones are listed above and include maltol and kojic acid, among others. Compound B, a tropolone derivative, is a compound derived from tropolone, a sevenmembered, aromatic, non-benzenoid ring structure with alternating double bonds and a hydroxyl group. Tropolone derivatives are compounds in which the basic tropolone structure is modified by substituting or attaching different functional groups to the sevenmembered ring. Examples of tropolone derivatives include hinokitiol (p-Thujaplicin), thujaplicin, eucarvone and colchicine. Preferred tropolone derivatives are tropolone and hinokitiol.

[0038] Compound C, a phenylpropanoid, is an organic compound derived from phenylalanine, characterized by a phenyl ring connected to a three-carbon chain. Examples of phenylpropanoids include cinnamic aldehyde (cinnamal), cinnamyl alcohol, hydroxycinnamaldehyde, anethol, dilapiol, allyl anisole, isoeugenol, eugenol, anethole and flavonoids.

[0039] Compound D, a monoterpene or monoterpenoid, is predominantly found in essential oils. Monoterpenes are compounds consisting of two isoprene units. Examples of (natural) monoterpenes include p-menthan, safranal, iridodial, fenchan, limonene, carvone, pinene, piperitone, citral, or one of the two isomers geranial and neral, and ocimene. Preferably, the term monoterpenes encompasses aromatic, alicycic or aliphatic structures, comprising two isoprene units. More preferably, monoterpenes are understood as aromatic or alicyclic structures, comprising two isoprene units. Monoterpenoids are a class of organic compounds derived from monoterpenes. This includes the products of (bio)chemical reactions between a monoterpene and another scaffold such as a carbohydrate as well as monoterpenes that contain additional functional groups after being (bio)chemically modified (e.g., by addition of new functional groups such as hydroxyl groups, ketones, aldehydes et cetera). Preferably the term monoterpenoid is used to describe the group of heteroatomcontaining molecules, which carbon structure comprises two fused isoprene units. More preferably, monoterpenoid is understood in this context as the group of alcohols, ketones, aldehydes or carboxylic acids of monoterpenes. Most preferably the term monoterpenoid describes the alcohols, ketones, aldehydes or carboxylic acids of aromatic or alicyclic monoterpenes. Examples of monoterpenoids include thymol, carvacrol, geraniol, menthol, linalool and eucalyptol (1 ,8-cineole), citronellol, (+) / (-)menthone, campher, camphene, grapefruit mercaptane, myrcene, perillyl alcohol.

[0040] Should there be an overlap between the class of tropolone derivatives and the class of monoterpenes or monoterpenoids, the overlapping part is to be allocated to the group of tropolone derivatives. In other words, compound D, a monoterpene or monoterpenoid, as understood herein is chemically a monoterpene or monoterpenoid other than a tropolone derivative.

[0041] Compound E, an aromatic acid or salt thereof, is characterized by an aromatic system when hydrogen atoms are substituted by carboxyl groups. Dependent on the number of carboxylgroups mono-, di-, and tri-substituted aromatic acids are distinguished. Examples include benzoic acid, anisic acid, phenylacetic acid, terephthalic acid, salicylic acid, p- aminobenzoic acid and their salts. Mono substituted aromatic acid (monobasic aromatic acid) and salts are preferred. Most preferred is anisic acid and its salts.

[0042] Compound F, a dipeptide, is a molecule consisting of two amino acids linked together by a peptide bond. Several dipeptides exist in nature such as Carnosine (p-alanyl-L-histidine), Anserine (p-alanyl-1-methyl-L-histidine), Kyotorphin (tyrosine-arginine), Aspartame (aspartyl-phenylalanine methyl ester), Balenine (p-alanyl-L-methylhistidine) and L-alanyl- L-glutamine.

[0043] Compound G, an alkanediol, is a group of substances consisting of linear or branched hydrocarbon chains containing exactly two hydroxy groups at different positions. The term “alkanediol” within the context of the present invention also includes its constitutional isomers or position isomers. Constitutional isomers are compounds that have the same molecular formula and different connectivity. Position isomers, a particular form of constitutional isomerism, are structural isomers that can be viewed as differing only on the position of a functional group on a parent structure, which in this case is the position of the two alcohol functions.

[0044] Preferred mixtures of the invention include maltol as compound A. In addition to providing synergistic chelating effects together with the other compounds of the mixture of the invention, maltol is a versatile ingredient in cosmetic formulations, contributing to fragrance, flavor, antioxidant protection, stability, skin conditioning and overall product sensory attributes.

[0045] Preferred mixtures of the invention include hinokitiol, tropolone or thujaplicin as compound B. Hinokitiol is a multifunctional ingredient, offering not only synergistic chelating effects in combination with the other compounds of the mixture, but also anti-inflammatory, antioxidant and skin conditioning properties.

[0046] Preferred mixtures of the invention include cinnamal, eugenol, cinnamyl alcohol, isoeugenol, eugenol and flavonoids, preferably cinnamal or isoeugenol, most preferably cinnamal, as compound C. Its benefits include synergistic chelating effects together with the other compounds of the mixtures of the invention, as well as fragrance and antimicrobial effects.

[0047] Preferred mixtures of the invention include a monoterpene or terpenoid as compound D. Preferred are piperitone, citral, limonene, thymol, carvacrol, more preferred are piperitone or citral, or an extract containing high amounts of the ingredients e.g., Litsea cubeba oil, Eucalyptus dives oil.

[0048] Preferred mixtures of the invention include anisic acid, in particular, p-anisic acid as compound E. In addition to strong chelating effects in combination with the other compounds of the mixtures of the invention, anisic acid is a versatile ingredient, offering fragrance, pH adjustment and potential skin conditioning.

[0049] Preferred mixtures of the invention include carnosine as compound F. In addition to synergistic chelating properties in combination with the other compounds of the mixtures of the invention, carnosine is particularly valued for its anti-aging and protective effects on the skin.

[0050] Preferred mixtures of the invention include a vicinal alkanediol as compound G. Preferably, compound G is a vicinal alkanediol having a linear carbon chain of 3 to 14 carbon atoms. Preferred vicinal alkanediol include 1 ,2-propanediol, 1 ,2-pentanediol, 1 ,2-hexanediol, 1 ,2- heptanediol, 1 ,2-octanediol, 1 ,2-nonanediol and 1 ,2-decanediol. 1 ,2-pentanediol is particularly preferred. Advantageously, 1 ,2-alkanediols not only provide chelating activity in conjunction with the other compounds of the mixture of the invention, but may also serve as humectant, solvent and emollient.

[0051] As already mentioned above, any of compounds A to G may be provided as single compounds, or as one or more complex mixtures such as natural extracts).

[0052] With respect to the (relative) amounts of components A to G in the mixture, one, two, three, four, five, six, seven, eight, nine, ten or even more than ten of the following may be fulfilled for mixtures of the invention:

[0053] (i) a weight ratio of compound A to compound B ranges from 1 :1 to 1500:1 ,

[0054] (ii) a weight ratio of compound A to compound C may range from 1 :2 to 1500:1 ,

[0055] (iii) a weight ratio of compound B to compound C may range from 1 :100 to 50:1 ,

[0056] (iv) a weight ratio of compound A to compound D ranges from 1 :30 to 150:1 ,

[0057] (v) a weight ratio of compound C to compound D ranges from 1 :1500 to 10:1 , (vi) a weight ratio of compound A to compound E ranges from 1 :16 to 75:1 ,

[0058] (vii) a weight ratio of compound B to compound E ranges from 1 :800 to 2.5:1 ,

[0059] (viii) a weight ratio of compound C to compound E ranges from 1 :800 to 5:1 ,

[0060] (ix) a weight ratio of compound D to compound E ranges from 1 :80 to 75:1 ,

[0061] (x) a weight ratio of compound A to compound F ranges from 1 :6 to 150:1 ,

[0062] (xi) a weight ratio of compound C to compound F ranges from 1 :300 to 10:1 ,

[0063] (xii) a weight ratio of compound E to compound F ranges from 1 :15 to 80:1 ,

[0064] (xiii) a weight ratio of compound B to compound D ranges from 1 :1500 to 5:1 ,

[0065] (xiv) a weight ratio of compound B to compound E ranges from 1 :800 to 2.5:1 ,

[0066] (xv) a weight ratio of compound D to compound F ranges from 1 :30 to 150:1 ,

[0067] (xvi) a weight ratio of compound A to compound G ranges from 1 :140 to 150:1 ,

[0068] (xvii) a weight ratio of compound B to compound G ranges from 1 :7000 to 5:1 , (xviii) a weight ratio of compound C to compound G ranges from 1 :7000 to 10:1 ,

[0069] (xix) a weight ratio of compound D to compound G ranges from 1 :700 to 150:1 ,

[0070] (xx) a weight ratio of compound E to compound G ranges from 1 :350 to 80:1 ,

[0071] (xxi) a weight ratio of compound F to compound G ranges from 1 :700 to 30:1 .

[0072] More preferably, a weight ratio of compound A to compound B ranges from 1 :0.8 to 1000:1 . More preferably, a weight ratio of compound A to compound C ranges from 1 :1 .6 to 500:1 . More preferably, a weight ratio of compound B to compound C ranges from 1 :80 to 20:1 . More preferably, a weight ratio of compound A to compound D ranges from 1 :26 to 33:1 . More preferably, a weight ratio of compound C to compound D ranges from 1 :650 to 3:1 . More preferably, a weight ratio of compound A to compound E ranges from 1 :10 to 20:1. More preferably, a weight ratio of compound B to compound E ranges from 1 :500 to 0.8:1 . More preferably, a weight ratio of compound C to compound E ranges from 1 :250 to 1 .6:1 . More preferably, a weight ratio of compound D to compound E ranges from 1 :17 to 26:1 . More preferably, a weight ratio of compound A to compound F ranges from 1 :5 to 70:1 .

[0073] More preferably, a weight ratio of compound C to compound F ranges from 1 :125 to 5:1 . More preferably, a weight ratio of compound E to compound F ranges from 1 :5 to 33:1 . More preferably, a weight ratio of compound B to compound D ranges from 1 :1300 to 1 .3:1 . More preferably, a weight ratio of compound B to compound E ranges from 1 :500 to 0.8:1 . More preferably, a weight ratio of compound D to compound F ranges from 1 :8 to 90:1 . More preferably, a weight ratio of compound A to compound G ranges from 1 :120 to 20:1 . More preferably, a weight ratio of compound B to compound G ranges from 1 :6000 to 0.8:1. More preferably, a weight ratio of compound C to compound G ranges from 1 :3000 to 1 .6:1 . More preferably, a weight ratio of compound D to compound G ranges from 1 :200 to 26:1 . More preferably, a weight ratio of compound E to compound G ranges from 1 :120 to 10:1 . More preferably, a weight ratio of compound F to compound G ranges from 1 :400 to 5:1 . Most preferably, a weight ratio of compound A to compound B ranges from 1 :0.3 to 700:1 .

[0074] Most preferably, a weight ratio of compound A to compound C ranges from 1 :0.5 to 140:1 .

[0075] Most preferably, a weight ratio of compound B to compound C ranges from 1 :50 to 6:1 .

[0076] Most preferably, a weight ratio of compound A to compound D ranges from 1 :5 to 0.7:1 .

[0077] Most preferably, a weight ratio of compound C to compound D ranges from 1 :100 to 0.05:1 . Most preferably, a weight ratio of compound A to compound E ranges from 1 :5 to 14:1 . Most preferably, a weight ratio of compound B to compound E ranges from 1 :500 to 0.6:10. Most preferably, a weight ratio of compound C to compound E ranges from 1 :100 to 1 :1 . Most preferably, a weight ratio of compound D to compound E ranges from 1 :0.5 to 10:1 . Most preferably, a weight ratio of compound A to compound F ranges from 1 :2 to 35:1 . Most preferably, a weight ratio of compound C to compound F ranges from 1 :40 to 2.5:1 . Most preferably, a weight ratio of compound E to compound F ranges from 1 :4 to 0.25:1 .

[0078] Most preferably, a weight ratio of compound B to compound D ranges from 1 :500 to 0.03:1. Most preferably, a weight ratio of compound B to compound E ranges from 1 :500 to 0.6:1 . Most preferably, a weight ratio of compound D to compound F ranges from 1 :0.2 to 25:1 . Most preferably, a weight ratio of compound A to compound G ranges from 1 :50 to 7:1 . Most preferably, a weight ratio of compound B to compound G ranges from 1 :5000 to 0.3:1 . Most preferably, a weight ratio of compound C to compound G ranges from 1 :1000 to 0.5:1 . Most preferably, a weight ratio of compound D to compound G ranges from 1 :5 to 5:1 . Most preferably, a weight ratio of compound E to compound G ranges from 1 :100 to 5:1 . Most preferably, a weight ratio of compound F to compound G ranges from 1 :250 to 2:1 .

[0079] The synergistic chelating activities of the compounds contained in the mixtures of the invention have been confirmed by determining binding (complex formation) capability of cupric and / or ferrous ions of the mixtures as compared to the respective binding capability of the respective pure compounds. The binding capability was determined indirectly by measuring the amount of cupric and / or ferrous ions bound to a reference compound (Pyrocatechol Violet and / or Ferrozine) using absorbance measurement, whereby binding to the reference compound is assumed to be only possible if the binding capability of the compounds / mixture of the invention is exhausted. This gave a quantitative indication of the synergistic effect. The synergism is particularly remarkable for combinations of two or three compounds chosen from maltol, cinnamal, hinokitiol, carnosine and a 1 ,2-alkanediol as specified herein.

[0080] Therefore, particularly preferred mixtures comprise, or consist of, the following combinations of compounds:

[0081] (a) Maltol, hinokitiol and cinnamal,

[0082] (b) Maltol, cinnamal and Carnosine,

[0083] (c) Hinokitiol, cinnamal and Carnosine, (d) Hinokitiol, cinnamal and a 1 ,2-alkanediol, preferably 1 ,2-pentanediol,

[0084] (e) Hinokitiol, Carnosine and a 1 ,2-alkanediol, preferably 1 ,2-pentanediol,

[0085] (f) Maltol, hinokitiol and a 1 ,2-alkanediol, preferably 1 ,2-pentanediol,

[0086] (g) cinnamal and hinokitiol,

[0087] (h) any of the mixtures above in which the 1 ,2- alkanediol is selected from the group consisting of 1 ,2-hexanediol, 1 ,2-heptanediol, 1 ,2-octanediol, 1 ,2-nonanediol, 1 ,2- decanediol,

[0088] (i) any of the mixtures above in which one of maltol, hinokitiol, cinnamal, carnosine and 1 ,2-pentanediol is replaced by anisic acid,

[0089] (j) any of the mixtures above in which one of maltol, hinokitiol, cinnamal, carnosine, anisic acid and 1 ,2-pentanediol is replaced by piperitone.

[0090] Yet further preferred mixtures comprise, or consist of, the following combinations of compounds:

[0091] Maltol, Cinnamal, Anisic Acid,

[0092] Maltol, Hinokitiol, Anisic Acid,

[0093] Maltol, Cinnamal, Piperitone,

[0094] Maltol, Hinokitiol, Piperitone,

[0095] Maltol, Piperitone, Anisic Acid,

[0096] Maltol, Anisic Acid, Pentylenglycol,

[0097] Maltol, Anisic Acid, 1 ,2-hexanediol,

[0098] Maltol, Anisic Acid, 1 ,2-heptanediol,

[0099] Maltol, Anisic Acid, Caprylyl Glycol,

[0100] Maltol, Anisic Acid, Decylene Glycol,

[0101] Maltol, Piperitone, Pentylenglycol,

[0102] Maltol, Piperitone, 1 ,2-hexanediol,

[0103] Maltol, Piperitone, 1 ,2-heptanediol,

[0104] Maltol, Piperitone, Caprylyl Glycol,

[0105] Maltol, Piperitone, Decylene Glycol,

[0106] Anisic Acid, Piperitone, Pentylenglycol,

[0107] Anisic Acid, Piperitone, 1 ,2-hexanediol,

[0108] Anisic Acid, Piperitone, 1 ,2-heptanediol,

[0109] Anisic Acid, Piperitone, Caprylyl Glycol,

[0110] Anisic Acid, Piperitone, Decylene Glycol,

[0111] Maltol, Citral, Anisic Acid,

[0112] Maltol, Citral, Pentylene Glycol,

[0113] Maltol, Citral, Hexanediol,

[0114] Maltol, Citral, Heptanediol, Maltol, Citral, Decylene Glycol,

[0115] Maltol, 4-Hydroxyacetophenone, Anisic Acid,

[0116] Maltol, 4-Hydroxyacetophenone, Pentylene Glycol,

[0117] Maltol, 4-Hydroxyacetophenone, 1 ,2-heptanediol,

[0118] Maltol, 4-Hydroxyacetophenone, Decylene Glycol,

[0119] Maltol, Anisic Acid, Caprylhydroxamic Acid,

[0120] Maltol, Caprylhydroxamic Acid, Pentylene Glycol,

[0121] Maltol, Caprylhydroxamic Acid, 1 ,2-Hexanediol,

[0122] Maltol, Caprylhydroxamic Acid, Decylene Glycol,

[0123] Maltol, Sodium Gluconate, Anisic Acid,

[0124] Maltol, Sodium Gluconate, Pentylene Glycol,

[0125] Maltol, Sodium Gluconate, 1 ,2-Hexanediol,

[0126] Maltol, Sodium Gluconate, 1 ,2-Heptanediol,

[0127] Maltol, Sodium Gluconate, Caprylyl Glycol,

[0128] Maltol, Sodium Gluconate, Decylene Glycol,

[0129] Maltol, Sodium Phytate, Pentyleneglycol,

[0130] Maltol, Carnosine,

[0131] Maltol, Carnosine, Pentylene Glycol,

[0132] Maltol, Carnosine, 1 ,2-Hexanediol,

[0133] Maltol, Carnosine, 1 ,2-Heptanediol,

[0134] Maltol, Carnosine, Caprylyl Glycol,

[0135] Maltol, Carnosine, Decylene Glycol.

[0136] As mentioned above, the mixtures of the invention can serve as a synergistically acting chelating mixture, and is thus useful for providing or contributing to overall stabilization, prevention of microbial growth, improved efficacy of active ingredients, enhanced appearance and texture as well as reduction of hard water effects of pharmaceutical, cosmetic, personal care, animal care or homecare formulations. Accordingly, the mixture may be selected among cosmetically acceptable mixtures, pharmaceutically acceptable mixtures, and mixtures acceptable for personal care, animal care and homecare formulations.

[0137] Another aspect of the present invention is a formulation comprising the mixture of the invention. The formulation may be a pharmaceutical or cosmetic formulation, or a formulation for personal care, animal care or homecare.

[0138] It has been found and hence it is preferred that the respective amounts of the compounds chosen among compounds A to G are sufficient to synergistically provide or contribute to the chelating effects in the formulation. Accordingly, the present invention provides the following preferred embodiments:

[0139] In preferred formulations, an amount of component A ranges from 0.05 to 1.5 % (500 to 15.000 ppm) by weight, preferably 0.05 to 1 % by weight, more preferably 0.1 to 0.7 % by weight, relative to the total weight of the formulation.

[0140] In further preferred formulations, an amount of component B ranges from 0.001 to 0.05 % by weight, preferably 0.001 to 0.04 % by weight, more preferably 0.001 to 0.03 % by weight, relative to the total weight of the formulation.

[0141] In yet further preferred formulations, an amount of component C ranges from 0.001 to 0.1 % by weight, preferably 0.002 to 0.08 % by weight, more preferably 0.005 to 0.05 % by weight, relative to the total weight of the formulation.

[0142] In yet further preferred formulations, an amount of component D ranges from 0.01 to 1 .5 % by weight, preferably 0.03 to 1.3 % by weight, more preferably 0.05 to 1.0 % by weight, relative to the total weight of the formulation.

[0143] In yet further preferred formulations, an amount of component E ranges from 0.02 to 0.8 % by weight, preferably 0.05 to 0.5 % by weight, more preferably 0.05 to 0.5 % by weight, relative to the total weight of the formulation.

[0144] In yet further preferred formulations, an amount of component F ranges from 0.01 to 0.3 % by weight, preferably 0.015 to 0.25 % by weight, more preferably 0.02 to 0.2 % by weight, relative to the total weight of the formulation.

[0145] In yet further preferred formulations, an amount of component G ranges from 0.01 to 7.0 % by weight, preferably 0.05 to 6 % by weight, more preferably 0.1 to 5 % by weight, relative to the total weight of the formulation.

[0146] Preferred formulations comprise two among compounds A to G, in which an amount of the two compounds is as specified above. Particularly preferred formulations comprise three among compounds A to G, in which an amount of one, preferably two, more preferably all three compounds is as specified above. Further formulations may comprise four among compounds A to G, in which an amount of two orthree ofthe four compounds is as specified above. Yet further formulations comprise four among compounds A to G, in which an amount of the four compounds is as specified above. Yet further formulations comprise all five compounds A to G, in which an amount of two or three or four of the five compounds is as specified above. Yet further formulations comprise all five compounds A to G, in which an amount of the five compounds is as specified above. Generally, one or more of compounds A to G may be synthetic compound(s) or natural compound(s). Formulations of the invention may also comprise partly synthetic compounds and partly natural compounds. Preferred formulations are free of synthetic compounds. A synthetic compound as understood herein is a compound that does not exist in nature, irrespective whether it has been provided by chemical synthesis or isolated from nature.

[0147] It is believed that addition of another chelating agent enhances the synergistic effect, and / or provides an additional synergistic efficacy. Accordingly, the formulation according to the present invention preferably includes one or more further chelating agents which are different from the compounds included in the mixture of the invention. For instance, the formulation of the invention may comprise one or more chelating agents selected from the group consisting of: EDTA (Ethylenediaminetetraacetic Acid) and its derivatives (Disodium EDTA, Tetrasodium EDTA, Trisodium EDTA), Sodium Phytate (Phytic Acid), Caprylhydroxamic Acid, Gluconolactone, Ascorbic Acid and its derivatives and salts, Citric Acid and its derivatives and salts, 2-hydroxyacetophenone, 4-Hydroxyacetophenone, Trisodium Ethylenediamine Disuccinate, Dehydroacetic Acid, Sodium Gluconate (Gluconic Acid), Mandelic acid, Pentasodium Pentetate, Tartaric acid and its derivatives and salts, as well as humic acids, bile acids, bile extracts & bilirubin, Lactic Acid, Hydroxyethyl Ethylenediamine Triacetic Acid (HEDTA), Etidronic Acid (HEDP), Tetrasodium Glutamate Diacetate, Tetrasodium Phyrophosphate, Malic acid and its derivatives and salts, a- hydroxy fatty acids, EGTA, MGDA (Trisodiumdicarboxymethyl alaninante), and their derivatives.

[0148] In a preferred variant the chelating agent is selected from the group consisting of EDTA (Ethylenediaminetetraacetic Acid) and its derivatives (Disodium EDTA, Tetrasodium EDTA, Trisodium EDTA), Caprylhydroxamic Acid, Sodium Phytate (Phytic Acid), Citric Acid and its derivatives and salts, Trisodium Ethylenediamine Disuccinate, Dehydroacetic Acid, Sodium Gluconate (Gluconic Acid), Etidronic Acid (HEDP), Tetrasodium Glutamate Diacetate, 4-hydroxyacetophenone, 2-hydroxyacetophenone and their derivatives.

[0149] The formulation according to the present invention preferably includes, in addition to the mixture of the invention, one or more antimicrobial agents. These antimicrobials act primarily against microorganisms, in particular bacteria, yeast and / or fungi, preferably, against microorganisms selected from the group consisting of Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Burkholderia cepacian, Candida albicans and Aspergillus brasiliensis, and combinations thereof. By suppressing or inhibiting the microorganisms’ growth, the degradation and deterioration of the formulation, in particular during storage, which sometimes goes along with impairment of the sensory quality of the products, can be prevented or at least minimized. The antimicrobial agent may be selected from the group consisting of Butyl paraben, 2- Benzylheptanol, 4-Hydroxyacetophenone, Alkyl (C 12-22) Trimethyl Ammonium Bromide and Chloride, Ascorbic Acid and salts thereof, Benzalkonium Bromide, Benzalkonium Chloride, Benzalkonium Saccharinate, Benzethonium Chloride, Benzyl Alcohol, Camphor, Caprylhydroxamic acid, Cetylpyridinium Chloride, Chlorhexidine, Chlorhexidine Diacetate, Chlorhexidine Digluconate, Chlorhexidine Dihydrochloride, Chlorocresol, Chloroxylenol, Chlorphenesin, Cyclohexylglycerin, Dehydroacetic Acid, Diazolidinyl Urea, Disodium EDTA, DMDM Hydantoin, Ethylhexylglycerin, Ethylparabene, Glycerin, Glyceryl Caprate, Glyceryl caprylate, Glyceryl Heptanoate, Hexamidine, Hexamidine Diisethionate, Hexylglycerin, Hydroxypropyl benzoate, Hydroxyethoxyphenyl Butanol, Hydroxyethoxyphenyl Butanone, lodopropynyl Butylcarbamate, Isobutylparaben, Itaconic Acid and salts thereof, Lactic Acid, Methyl Salicylate, Methylchloroisothiazolinone, Methylisothiazolinone, Methylparaben and its salts, Natamycin, Nisin, Phenethyl Alcohol, Phenoxyethanol, Phenylpropanol, Polyarginine, Polylysine, Potassium Sorbate, Propylparaben, Silver Chloride, Silver Citrate, Sodium Benzoate, Sodium Ethylparaben, Sodium Levulinate or Levulinic Acid and esters and / or ketals thereof, Sodium Propylparaben, Sorbic Acid, Sorbitan Caprylate, TEA-Salicylate, Tetrasodium Glutamate Diacetate, Triclocarban, Trisodium Ethylenediamine Disuccinate, Zinc Citrate, Trisodium Dicarboxym ethyl Alaninate, 1 ,3-propanediol, 1 ,2-pentanediol, 1 ,2-hexanediol, 1 ,2- heptanediol, 1 ,2-octanediol, 1 ,2-nonanediol, 1 ,2-decanediol, 2,3-pentanediol, 2,3- pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more the aforesaid compounds.

[0150] In a preferred variant, the antimicrobial agent is selected from the group consisting of 4- Hydroxyacetophenone, Benzyl Alcohol, Butyl paraben, Caprylhydroxamic acid, Chlorhexidine, Chlorhexidine Digluconate, Chlorphenesin, Diazolidinyl Urea, Disodium EDTA, DMDM Hydantoin, Ethylparaben, Ethylhexylglycerin, Glyceryl Caprate, Glyceryl Caprylate, Glyceryl Laurate, Hydroxypropyl benzoate, Hydroxyethoxyphenyl Butanol, Hydroxyethoxyphenyl Butanone, lodopropynyl Butylcarbamate, Isobutylparaben, Itaconic Acid, Methylchloroisothiazolinone, Methylisothiazolinone, Methylparaben and its salts, Natamycin, Nisin, Phenethyl Alcohol, Phenoxyethanol, Potassium Sorbate, Propylparaben, Sodium Benzoate, Sodium Ethylparaben, Sodium Propylparaben, Sorbitan Caprylate, TEA-Salicylate, Tetrasodium Glutamate Diacetate, Trisodium Ethylenediamine Disuccinate, Dehydroacetic Acid, 1 ,3-propanediol, 1 ,2-pentanediol, 1 ,2-hexanediol, 1 ,2- heptanediol, 1 ,2-octanediol, 1 ,2-nonanediol, 1 ,2-decanediol, 2,3-pentanediol, 2,3- hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, and mixtures of two or more the aforesaid compounds. In a particularly preferred variant, the antimicrobial agent is selected from the group consisting of 4-Hydroxyacetophenone, Benzyl Alcohol, Butylparaben, Caprylhydroxamic acid, Disodium EDTA, DMDM Hydantoin, Ethylparaben, Ethylhexylglycerin, Glyceryl Caprylate, Glyceryl heptanoate, Hydroxypropyl benzoate, Hydroxyethoxyphenyl Butanol, Hydroxyethoxyphenyl Butanone, Itaconic Acid, Methylchloroisothiazolinone, Methylisothiazolinone, Methylparaben, Natamycin, Nisin, Phenoxyethanol, Potassium Sorbate, Propylparaben, Sodium Benzoate, Sodium Propylparaben, Dehydroacetic Acid, 1 ,3- propanediol, 1 ,2-pentanediol, 1 ,2-hexanediol, 1 ,2-heptanediol, 1 ,2-octanediol, 1 ,2- nonanediol, 1 ,2-decanediol, 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3- octanediol, 2,3-nonanediol, and mixtures of two or more the aforesaid compounds.

[0151] In another preferred variant, the antimicrobial agent is selected from the group consisting of 4-Hydroxyacetophenone, Benzyl Alcohol, Caprylhydroxamic acid, Disodium EDTA, Ethylhexylglycerin, Glyceryl Caprylate, Hydroxypropyl benzoate, Methylparaben, Nisin, Phenoxyethanol, Potassium Sorbate and Sodium Benzoate.

[0152] The aforesaid antimicrobial agents can be used either as a single component or in combination with one or more other antimicrobial agents. In order to enhance the antimicrobial effect and to cover a broader range of antimicrobial effect, a combination of two or more antimicrobial agents is preferably used.

[0153] Additionally, one or more polymers as viscosity controlling agent may be included in the formulation. The viscosity controlling agent may be selected among Xanthan Gum, Hydroxyethylcellulose, Cellulose Gum, Cellulose, Aluminium Starch Octenylsuccinate, Hydroxypropyl Methylcellulose, Acacia Senegal Gum, Microcrystalline Cellulose, Sclerotium Gum, Carrageenan and salts, Hydroxypropylcellulose, Dextrin, Algin, Caesalpinia Spinosa gum, Sodium Starch Octenylsuccinate, Galactoarabinan, Hydroxypropyl Guar, Cyamopsis Tetragonoloba Gum, Sodium Polyacrylate Starch, Cetyl Hydroxyethylcellulose, Ethylcellulose, Sodium Carboxymethyl Betaglucan, Hydrolyzed Corn starch Octenylsuccinate, Pistacia Lentiscus Gum, Dehydroxanthan Gum, Pectin, Aery lates / C 10-30 Alkyl Acrylate Crosspolymer, Acrylates / beheneth-25 Methacrylate Copolymer; Ammonium Acryloyldimethyltaurate / VP Copolymer, Butylene / Ethylene / Styrene Copolymer, Carbomer, Cera Microcrystallina, Chondrus Crispus extract, Corn Starch Modified, Disteardimonium Hectorite, Glyceryl Acrylate / acrylic Acid Copolymer, Guar Hydroxypropyltrimonium Chloride, Hydroxyethyl Acrylate / Sodium Acryloyldimethyl Taurate Copolymer, PVP, Pentaerythrityl Tetraethylhexanoate, Phytosteryl / isostearyl / cetyl / stearyl / behenyl Dimer Dilinoleate, Sodium Acrylate / sodium Acryloyldimethyl Taurate Copolymer, Sodium Acrylates Copolymer, Sodium Polyacrlyate, Stearalkonium Bentonite, Tapioaca Starch, Zea (Mays) Corn starch, Gellan Gum, and mixtures thereof. Most preferred viscosity controlling agents include Xanthan Gum, Hydroxyethylcellulose, Cellulose Gum, Cellulose, Aluminium Starch Octenylsuccinate, Hydroxypropyl Methylcellulose, Acacia Senegal Gum, Microcrystalline Cellulose, Sclerotium Gum, Carrageenan and salts, Caesalpinia Spinosa gum, Hydroxypropyl Guar, Cyamopsis Tetragonoloba Gum, Aery lates / C 10-30 Alkyl Acrylate Crosspolymer, Carbomer, Guar Hydroxypropyltrimonium Chloride, and Tapioaca Starch.

[0154] The formulation of the invention may further include one or more active substances. An “active” substance within the meaning of the present invention means a component or a compound which imparts one or more than one benefit, functions or operate via more than one mode of action, such as anti-inflammatory, anti-itching, anti-redness, anti-dandruff, anti-microbial, anti-perspirant, deodorant, hair growth strengthening, anti-dark-spot, anticellulite, anti-oxidative, anti-wrinkle, skin-whitening, skin tanning, pain-reducing, swelling reduction, skin barrier strengthening, anti-mycotic, anti-sagging, and skin soothing properties.

[0155] Suitable active components are selected from the group consisting of abrasives, anti-acne agents, agents against ageing of the skin, anti-cellulitis agents, anti-dandruff agents, antiinflammatory agents, anti-microbial agents, irritation-preventing agents, irritation-inhibiting agents, antioxidants, astringents, odor absorbers, perspiration-inhibiting agents, antiseptic agents, cell stimulants, cleansing agents, depilatory agents, surface-active substances, deodorizing agents, antiperspirants, enzymes, enzyme inhibitors, hair care agents, hairsetting agents, hair-straightening agents, moisture-donating agents, moisturizing substances, moisture-retaining substances, bleaching agents, strengthening agents, stainremoving agents, optically brightening agents, impregnating agents, dirt-repellent agents, dyes, friction-reducing agents, lubricants, moisturizing creams, ointments, opacifying agents, covering agents, polish, gloss agents, green and synthetic polymers, powders, proteins, re-oiling agents, abrading agents, silicones, skin-soothing agents, skin-cleansing agents, skin care agents, skin-healing agents, skin-lightening agents, skin-protecting agents, skin-softening agents, hair promotion agents, cooling agents, skin-cooling agents, warming agents, skin-warming agents, stabilizers, surfactants, UV-absorbing agents, UV filters, primary sun protection factors, secondary sun protection factors, detergents, fabric conditioning agents, suspending agents, skin-tanning agents, actives modulating skin or hair pigmentation, matrix-metalloproteinase inhibitors, skin moisturizing agents, glycosaminoglycan stimulators, TRPV1 antagonists, desquamating agents, anti-cellulite agents or fat enhancing agents, hair growth activators or inhibitors, vitamins, oils, waxes, pearlizing waxes, fats, phospholipids, saturated fatty acids, mono- or polyunsaturated fatty acids, a-hydroxy acids, polyhydroxyfatty acids, liquefiers, dyestuffs, color-protecting agents, pigments, anti-corrosives, fragrances or perfume oils, aromas, flavoring substances, odoriferous substances, polyols, electrolytes, organic solvents, and mixtures of two or more of the aforementioned substances, as described herein.

[0156] The formulation of the invention may further include one or more auxiliary compounds. Auxiliary compounds, as understood herein, are supplementary ingredients that enhance the performance, stability, or appeal of the cosmetic formulation, but are not the main active ingredients. While the primary actives provide the main benefit (e.g., moisturizing, antiaging), auxiliary compounds assist in various ways, such as providing stabilization (they ensure the formulation stays homogenous and effective), aesthetic enhancement (improve texture, feel, color, and / or scent to make the formulation more appealing), protection (some provide preservative functions or protect against UV damage and oxidation), functional support (they help in better application and absorption of the main active ingredients). Within the framework of the present invention, the auxiliary compounds may be selected among preservatives, antimicrobial agents, antioxidants, viscosity modifiers (esp. thickeners), fragrances and perfuming agents, colorants and pigments, solvents, chelating agents, UV filters (sunscreens), anti-statics, binders, buffers, carrier materials, chelating agents, softeners, essential oils, fibers, film-forming agents, fixatives, foam-forming agents, foam stabilizers, substances for preventing foaming, foam boosters, gelling agents, gelforming agents, plasticizing agents, additives against ageing of the skin, surfactants, green and synthetic polymers, skin-cooling agents, rheology additives, oils, fragrances or perfume oils, and polyols.

[0157] Within the framework of the present invention, the active substance(s), adjuvant(s), additive(s), and / or auxiliary compound(s) may be selected among abrasives, agents against ageing of the skin, anti-cellulitis agents, antioxidants, astringents, odor absorbers, perspiration-inhibiting agents, anti-statics, binders, buffers, carrier materials, chelating agents, cell stimulants, depilatory agents, surface-active substances, deodorizing agents, antiperspirants, softeners, emulsifiers, enzymes, enzyme inhibitors, essential oils, fibers, film-forming agents, fixatives, foam-forming agents, foam stabilizers, substances for preventing foaming, foam boosters, gelling agents, gel-forming agents, hair care agents, hair-setting agents, hair-straightening agents, bleaching agents, strengthening agents, stain-removing agents, optically brightening agents, impregnating agents, dirt-repellent agents, dyes, friction-reducing agents, lubricants, opacifying agents, plasticizing agents, covering agents, polish, preservatives, gloss agents, green and synthetic polymers, powders, proteins, re-oiling agents, abrasives, silicones, skin-soothing agents, skin care agents, skin-healing agents, skin lightening agents, skin-protecting agents, skin-softening agents, hair promotion agents, warming agents, skin-warming agents, stabilizers, surfactants, UV-absorbing agents, UV filters, primary sun protection factors, secondary sun protection factors, detergents, fabric conditioning agents, suspending agents, skin-tanning agents, actives modulating skin or hair pigmentation, matrix-metalloproteinase inhibitors, glycosaminoglycan stimulators, TRPV1 antagonists, desquamating agents, anti-cellulite agents or fat enhancing agents, hair growth activators or inhibitors, anti-acne agents, agents against ageing of the skin, anti-dandruff agents, anti-inflammatory agents, (further) anti-microbial agents, irritation-preventing agents, irritation-inhibiting agents, astringents, odor absorbers, perspiration-inhibiting agents, antiseptic agents, cell stimulants, cleansing agents, depilatory agents, surface-active substances, deodorizing agents, antiperspirants, enzymes, enzyme inhibitors, hair care agents, hair-setting agents, hair-straightening agents, moisture-donating agents, moisturizing substances, moisture-retaining substances, bleaching agents, strengthening agents, stain-removing agents, optically brightening agents, impregnating agents, dirt-repellent agents, dyes, friction-reducing agents, lubricants, moisturizing creams, ointments, opacifying agents, covering agents, polish, gloss agents, green and synthetic polymers, powders, proteins, re-oiling agents, skin-cleansing agents, cooling agents, skin-cooling agents, fabric conditioning agents, vitamins, oils, waxes, pearlizing waxes, fats, phospholipids, saturated fatty acids, mono- or polyunsaturated fatty acids, a-hydroxy acids, poly hydroxyfatty acids, liquefiers, dyestuffs, color-protecting agents, pigments, anti-corrosives, fragrances or perfume oils, aromas, flavoring substances, odoriferous substances, polyols, electrolytes, organic solvents, and mixtures of two or more of the aforementioned substances, as described herein.

[0158] Among the aforementioned compounds preferred are agents against ageing of the skin, antioxidants, chelating agents, emulsifiers, surfactants, preservatives, green and synthetic polymers, rheology additives, oils, fragrances or perfume oils, polyols, and mixtures of two or more of the aforementioned agents.

[0159] The formulation according to the present invention may comprise a carrier or a mixture of different carriers. Preferred carrier materials are solid or liquid at 25°C and 1013 mbar (including highly viscous substances) as for example glycerol, 1 ,2-propylene glycol, 1 ,2- butylene glycol, 1 ,3-propylene glycol, 1 ,3-butylene glycol, ethanol, water, and mixtures of two or more of said liquid carrier materials with water. Other preferred liquid carrier substances are selected from the group consisting of oils such as vegetable, neutral and mineral oils.

[0160] Preferred solid carrier materials, which may be a component of the formulation according to the invention, are hydrocolloids, such as starches, degraded starches, chemically or physically modified starches, dextrins, (powdery) maltodextrins (preferably with a dextrose equivalent value of 5 to 25, preferably of 10 - 20), lactose, silicon dioxide, glucose, modified celluloses, gum arabic, ghatti gum, traganth, karaya, carrageenan, pullulan, curdlan, xanthan gum, gellan gum, guar flour, carob bean flour, alginates, agar, pectin, inulin, and mixtures of two or more of these solids, in particular maltodextrins (preferably with a dextrose equivalent value of 15 - 20), lactose, silicon dioxide and / or glucose.

[0161] Preferred formulations according to the present invention are intended for applications on a mammal’s skin (topical applications). The term “topical” is understood to mean external applications on a mammal’s skin, which are in particular for the treatment, protection, care and cleansing of the skin, scalp, eyelashes, eyebrows, nails, mucous membranes and hair. The mammal is preferably a human. For topical application, the formulations may be either rinse off or leave on preparations.

[0162] Preferred leave-on and rinse-off products include:

[0163] Moisturizers and Creams (e.g., face moisturizers, day creams, night creams), body lotions and body butters, sunscreens (e.g., SPF lotions, sprays, and creams for both face and body), Serums and Treatment Creams (e.g., Anti-aging serums (e.g., with retinoid, peptides, or hyaluronic acid), brightening serums with Vitamin C), Primers and Foundations (e.g., Makeup primers for a smooth base, Liquid foundations and BB / CC creams), Leave-In Hair Conditioners and Styling Products (e.g., Leave-in conditioners and serums for moisture and shine; Hair styling creams, gels, and sprays), Lip Balms and Lip Tints (e.g. Hydrating lip balms; Tinted lip products that provide color and hydration), Eye Creams (Targeted creams for hydration, antiaging, or de-puffing around the eyes), Acne Spot Treatments (e.g., Leave-on gels or creams with ingredients like salicylic acid or benzoyl peroxide), Body Oils and Creams (e.g., Hydrating body oils, creams, and lotions);

[0164] Cleansers (e.g., Face washes, foaming cleansers, and oil cleansers; Cleansing balms and milk cleansers), Shampoos and Conditioners (e.g., Hair cleansers for the scalp and hair; Rinse-off conditioners and hair masks, Body Washes and Shower Gels (e.g., Soaps and body cleansers), Exfoliating Scrubs (e.g., Face and body scrubs), Face Masks (e.g., Clay masks, sheet masks, or peel-off masks), Shaving Creams.

[0165] In another variant, formulations in accordance with the invention are useful for home care applications. For instance, the inventive formulations can be provided in a form of a household product selected from the group consisting of alcohol free glass cleaners, glass cleaners, all-purpose cleaners, all-purpose sprays, degreasers, carpet cleaners, wood cleaners, floor cleaners, laminate cleaners, vinyl cleaners, ceramic cleaners, cork cleaners, linoleum cleaners, porcelain cleaners, stone cleaners, concrete cleaners, parquet cleaners, high gloss floor cleaners, kitchen cleaners, fat solver cleaners, bathroom cleaners, toilet cleaners, chalk cleaners, automatic dish washes, hand dish wash fluids, antibacterial hand dish wash fluids, fabric softeners, fabric care, liquid laundry detergents, powder laundry detergents, and hygiene wash detergents.

[0166] The formulations according to the present invention can be present in different forms, e.g., in the form of a dispersion, a liquid surfactant formulation, a solid surfactant formulation, or an aqueous, aqueous / alcoholic, in particular aqueous / ethanolic, or an aqueous / glycolic based solution. Preferred are dispersions. The term “dispersion” in the context of the present invention means that the formulation is a dispersed two-phase system consisting of colloidal particles (disperse phase) and a medium in which they are suspended (disperse medium). Both phases are not miscible with each other. Such dispersions, for example emulsions, comprise at least an oil component, preferably in an amount of at least 0.01 % by weight and / or in an amount of 60.0 % by weight, or less.

[0167] If the formulation according to the present invention is an emulsion, the oil component is present in an amount of 0.01 to 60.0% by weight, based on the total weight of the formulation. In a preferred variant, the formulation comprises the oil component in an amount of 1.0 to 55.0 % by weight, based on the total weight of the formulation. In a particular preferred variant, the oil component is advantageously used in the formulation in an amount of at 3.0 to 35 % by weight, based on the total weight of the composition.

[0168] Suitable emulsions include a O / W emulsion, a W / O emulsion, a multiple emulsion, a hydro dispersion gel, a balm, a multiple emulsion of the water-in-oil type (W / O / WO) or of the oil- in-water type (O / W / O), PIT emulsion, Pickering emulsion, a micro-emulsion, a liquid, a lotion, a suspension, a milk, an ointment, a paste, a gel, a cream based, an oil based or a liposome-based formulation.

[0169] In a further alternative, the formulation according to the present invention is a liquid surfactant formulation. Such liquid surfactant formulations include for example shampoo, shower gel, micellar water, liquid soap, cleansing preparations. If the formulation according to the present invention is a liquid surfactant formulation, the surfactant component is present in an amount of 1 to 60 % by weight, preferably in an amount of 3 to 50 % by weight, more preferably in an amount of 4 to 40 % by weight, based on the total weight of the formulation.

[0170] In a further alternative, the formulation according to the present invention is a solid surfactant formulation. Such solid surfactant formulations include for example solid shampoos, solid body wash, bar soaps, etc.

[0171] Alternatively, the formulation as disclosed herein is an aqueous or aqueous / alcoholic or aqueous / glycolic based solution. Said solution is a homogeneous one phase system of water and additional components. The aqueous / alcoholic or aqueous / glycolic based solution comprises an aliphatic alcohol or a glycol in an amount of 0.1 to < 50 % by weight, preferably in an amount of 0.5 to 30 % by weight, more preferably in an amount of 2 to 20 % by weight, based on the total weight of the solution. The aliphatic alcohol is preferably selected from the group consisting of ethanol, isopropanol, n-propanol. The glycol is preferably selected from the group consisting of glycerin, propylene glycol, butylene glycol or dipropylene glycol. Preferably, the overall water content in the final solutions can be > 50 % by weight, more preferably > 70 % by weight, even more preferably > 80 % by weight, and in special cases particularly preferably even > 90 % by weight, based on the total weight of the solution. New applications such as those including solutions for water wipes have high water content. Such aqueous or aqueous / alcoholic or aqueous / glycolic based solutions include for example deo / antiperspirant preparations, after shave, cleansing preparations, or anti-acne preparations. In a preferred variant, the inventive formulation can be used for wet-wipe applications; they may then most preferably contain > 85 % by weight water, or even > 98 % by weight water.

[0172] In a preferred variant, the formulation according to the present invention is in the form of an emulsion as defined herein, advantageously in the form of an oil-in-water (O / W) emulsion comprising an oily phase dispersed in an aqueous phase in the presence of an O / W emulsifier.

[0173] Accordingly, the formulation of the invention may comprise an emulsifier. An emulsifier as understood herein refers to the ingredient(s) that serve to form and stabilize the foundational structure of the emulsion. Together with an optional co-emulsifier that helps the emulsifier(s) to stabilize the emulsion, the emulsion provides the medium in which cosmetic ingredients and / or functional additives can be incorporated. The emulsion, as understood herein, comprises, or consists of, an aqueous component, usually water or other water-soluble liquids (herein, water component or aqueous component), and a non- water-soluble component, typically oils, fats, or waxes (herein, oil phase or oil component).

[0174] The emulsifier serves to prevent that the emulsion collapses and that two separate phases are formed, and refers to one or more compounds with emulsifying properties. The emulsifier contributes to the overall emulsification properties of the formulation. The emulsifier may consist of, or comprise, a non-ionic emulsifier (e.g., Polysorbate), an anionic emulsifier (e.g., Glyceryl Stearate citrate), or a cationic emulsifier (e.g., Cetrimonium chloride). In some embodiment, an anionic emulsifier is preferred. In some embodiments, a non-ionic emulsifier is preferred. In some embodiment, a cationic emulsifier is preferred. According to a preferred embodiment of the formulation, an (anionic) emulsifier is selected from the group consisting of: emulsifiers based on amino acids, preferably sodium stearoyl glutamate, sodium stearoyl lactylate, aliphatic C12-22 fatty acids, preferably selected from the group consisting of palmitic acid, stearic acid, isostearic acid, lauric acid, arachidic acid, oleic acid,behenic acid, polyhydroxystearic acid, glyceryl esters and derivatives thereof, preferably glyceryl stearate citrate, glyceryl oleate citrate, esters of citric acid and aliphatic alcohols and derivatives thereof, more preferably selected from the group consisting of dilauryl citrate, phosphorous esters of phosphoric acid and aliphatic alcohols, preferably C8-22, more preferably C16-18, alcohols, and mixtures and salts thereof, most preferably selected from the group consisting of potassium cetyl phosphate, sodium cetyl phosphate, cetyl phosphate, oleth-10 phosphate, trilaureth-4 phosphate, and triceteareth-4 phosphate, sodium sulfosuccinate esters, preferably with C8-22, more preferably C16-18, alcohols, and mixtures thereof.

[0175] More preferred anionic emulsifiers include sodium stearoyl glutamate, sodium stearoyl lactylate, palmitic acid, stearic acid, glyceryl stearate citrate, glyceryl oleate citrate, dilauryl citrate, potassium cetyl phosphate, sodium cetyl phosphate, cetyl phosphate, and mixtures thereof. Most preferred is disodium cetearyl sulfosuccinate.

[0176] According to another embodiment of the formulation, a (non-ionic) emulsifier is selected from the group consisting of: fatty alcohols and alcohols, preferably selected from the group consisting of octyldodecanol, isocetyl alcohol, cetyl alcohol, stearyl alcohol, and cetearyl alcohol,, behenyl alcohol, sorbitan derivatives, preferably sorbitan mono or diesters with saturated or unsaturated fatty acids containing 6-22 carbon atoms and ethylene oxide addition products thereof, more preferably selected from the group consisting of polysorbate- 60, polysorbate-21 , sorbitan laurate, sorbitan stearate, sorbitan isostearate, sorbitan oleate, sorbitan olivate, sorbitan caprylate, PEG-40 sorbitan oleate, sorbeth-20 beeswax, polysorbate-20, sorbitan palmitate, sorbitan trioleate, sorbitan tristearate, sorbitan sesquioleate, PEG-80 sorbitan laurate, polysorbate-80, and polysorbate-81 , glyceryl derivatives, preferably glyceryl mono or diesters with saturated or unsaturated fatty acids containing 6-22 carbon atoms and ethylene oxide addition products thereof, more preferably selected from the group consisting of diisostearoyl polyglyceryl-3 dimer dilinoleate, glyceryl oleate, glyceryl stearate, glyceryl laurate, PEG-100 stearate, PEG-200 castor oil, PEG-29 castor oil, PEG-35 castor oil, PEG- 40 hydrogenated castor oil, polyglyceryl-2 dipolyhydroxystearate, polyglyceryl-2 Stearate polyglyceryl-2 isostearate, polyglyceryl-2 tri isostea rate, polyglyceryl-3 diisostearate, polyglyceryl-3 distearate, polyglyceryl-3 oleate, polyglyceryl-3 Caprylate, polyglyceryl-4 caprlyate / caprate, polyglyceryl-4 diisostearate / polyhydroxystearate / sebacate, polyglyceryl-4 isostearate, polyglyceryl-4 laurate, polyglyceryl-4 laurate / succinate, polyglyceryl-4 laurate / sebacate, polyglyceryl-6 behenate, polyglyceryl-6 palmitate / succinate, polyglyceryl-6 stearate, polyglyceryl-6 Distearate, tri(polyglyceryl-3 / lauryl) hydrogenated trilinoleate, polyglyceryl-2-sesquiisostearate, polyglyceryl-2 caprate, polyglyceryl-10 laurate, and polyglyceryl-3 polyricinoleate, hydrogenated palm glycerides, PEG-7 glyceryl cocoate, PEG-6 caprylic / capric glycerides, polyglyceryl- 3-caprate, PEG-5 bertholletia excelsa seed oily glyceryl esters, PEG-7 carapa guianensis glyceryl esters, PEG-7 caprylic / capric glycerides, PEG-7 theobroma grandiflorum seed butter glyceryl esters, cocoglycerides, glyceryl caprylate / caprate, glyceryl caprylate, glyceryl stearate, glyceryl oleate, glyceryl undecylenate, polyglyceryl-2 caprate, polyglyceryl-4 cocoate, polyglyceryl-3 diisostearate, and PEG-10 olive glycerides, lanolin compounds and derivatives thereof, preferably lanolin mono or diesters with saturated or unsaturated fatty acids containing 6-22 carbon atoms or ethylene oxide addition products thereof, more preferably selected from the group consisting of PEG-30 lanolin, lanolin alcohol, laneth-15, and laneth-40, carbohydrates, sugars and derivatives thereof, preferably selected from the group consisting of sucrose stearate, sucrose distearate, polyglyceryl 3-methylglucose distearate, methyl glucose sesquistearate, sucrose cocoate, lauryl glucoside, Cetearyl glucoside, Arachidyl glucoside, C12-20 alkyl Glucoside, and sucrose polystearate, and alkoxylated alcohols, preferably obtained from 1 mol C8-22 fatty alcohols and mixtures thereof and 2-50 mol ethylene or propylene oxide, more preferably selected from the group consisting of ceteareth-12, ceteareth-20, ceteareth-25, ceteareth-6, ceteareth-30, ceteareth-50, beheneth-10, behenth-25, ceteth-2, ceteth-10, ceteth- 20, laureth-23, laureth-4, laureth-7, oleth-10, oleth-20, oleth-3, oleth-30, oleth-5, PEG-40 hydrogenated castor oil, Hydrogenated lecithin PEG-5 rapeseed oil, PEG- 60 hydrogenated castor oil, PEG-7 hydrogenated castor oil, steareth-10, steareth- 100, steareth-2, steareth-20, steareth-21 , and PEG-40 Stearate.

[0177] More preferred non-ionic emulsifiers include cetyl alcohol, stearyl alcohol, and cetearyl alcohol, polysorbate-60, sorbitan isostearate, polysorbate-20, polysorbate-80, glyceryl stearate, polyglyceryl-3 Caprylate, polyglyceryl-4 caprlyate / caprate, glyceryl caprylate, polyglyceryl 3-methylglucose distearate, methyl glucose sesquistearate, Cetearyl glucoside, Arachidyl glucoside, ceteareth-12, ceteareth-20, laureth-7, PEG-40 hydrogenated castor oil, Hydrogenated lecithin, steareth-2, and steareth-21.

[0178] According to another embodiment of the formulation, a (cationic) emulsifier is selected from the group consisting of quaterny ammonium compounds including salts, preferably Behentrimonium chloride, Cetrimonium Chloride, Behentrimonium Methosulfate, Dicetyldimonium Chloride, Dipalmitoylethyl Hydroxyethylmonium Methosulfate, Distearoylethyl Dimonium chloride, Cetrimonium Methosulfate, Cinnamidopropyltrimonium Chloride, Dipalmitoylethyl Hydroxyethylmonium Methosulfate, Distearoylethyl Hydroxyethylmonium Methosulfate, Distearyldimonium Chloride, Guar Hydroxypropyltrimonium Chloride, Hydroxypropyl Guar Hydrxypropyltrimonium Chloride, Hydroxyproyltrimonium Hydrolyzed Wheat Protein, Laurdimonium Hydroxypropyl Hydrolyzed Keratin, Palmitamidopropyltrimonium Chloride, Polyquaternium-10, Polyquaternium-11 , Polyquaternium-16, Polyquaternium-22, Polyquaternium-37, Polyquaternium-47, Polyquaternium-55, Polyquaternium-7, Quaternium-18, Quaternium- 80, Quaternium-87, Quaternium-91 . Stearalkonium Chloride, Steartrimonium Chloride, and Stearamidopropyl Diemthylamine.

[0179] More preferred cationic emulsifiers include Behentrimonium chloride, Cetrimonium Chloride, Behentrimonium Methosulfate, Dicetyldimonium Chloride, Distearoylethyl Hydroxyethylmonium Methosulfate, Polyquaternium-10, Polyquaternium-37, Polyquaternium-7, Steartrimonium Chloride, and Stearamidopropyl Diemthylamine.

[0180] The emulsifier may be a single substance or a combination of two or more substances.

[0181] Moreover, preferred formulations may include an oil component (also referred to herein as “oil phase”). The oil component in the formulation according to the present invention may be selected from the group consisting of plant oils, hydrocarbons, fatty alcohols, fatty acid esters, liquid UV filters, or mixtures of two or more of oil components. The term “oil component” also encompasses wax.

[0182] According to a preferred embodiment, the oil component is selected from the group consisting of: esters, more preferably selected from the group consisting of cetearyl nonanoate, propanediol dicaprylate / caprate, propanediol caprylate, ethylhexyl isononanoate, PPG3 benzyl ether myristate, cetyl palmitate, myristyl myristate, myristyl stearate, myristyl oleate, myristyl behenate, ethylhexyl hydroxystearate, DI-PPG-3 myristyl ether adipate, DIPPG-2 myreth-10 adipate, PPG-15 stearyl ether, diethylhexyl succinate, propylene glycol isostearate, diethylhexyl adipate, butyl stearate, ethylhexyl cocoate, ethylhexyl stearate, pentaerythrityl tetracaprylate / tetracaprate, tridecyl neopentanonate, myristyl lactate, PPG-10 cetyl ether, PPG-15 stearyl ether, pentaerythrityl stearate / caprate / caprylate adipate, diisopropyl dimer dilinoleate, isopropyl isostearate, pentaerythrityl tetraisostearate, C12-15 alkyl benzoate, triisononanoin, isostearyl isostearate, triisostearin, trimethylolpropane tri isostea rate, diisopropyl adipate, isocetyl stearate, propylene glycol dicaprlyate / dicaprate, PPG 2 myristyl ether propionate, isostearyl neopentanoate, isopropyl palmitate, isopropyl myristate, cetyl esters, bis-diglyceryl polyacyladipate-2, isoamyl cocoate, cetyl ethylhexanoate, cetyl ricinoleate, decyl cocoate, diethylhexyl carbonate, decyl oleate, cetearyl ethylhexanoate, lauryl oleate, oleyl erucate, ethylhexyl palmitate, ethylhexyl palmitate, stearyl heptanoate, phenoxyethyl caprylate, hexyl laurate, dibutyl adipate, coco-caprlyate, dicaprylyl carbonate, coco-caprylate / caprate, caprylyl caprylate, caprylyl capylate / caprate, propylheptyl caprylate, decyltetradecyl ethylhexanoate, cetearyl isononanoate, neopentyl glycol diheptanoate, diheptyl succinate, dipropylheptyl carbonate, heptyl undecylenate, propylene glycol dibenzoate, isopropyl laurate, propylene glycol diethylhexanoate, cetyl lactate, lauryl lactate, C12-15 alkyl lactate, diethylhexyl malate, isocetyl stearoyl stearate, isodecyl neopentanoate, cetyl myristate, cetyl palmitate, cetyl stearate, cetyl isostearate, cetyl oleate, cetyl behenate, cetyl erucate, stearyl myristate, stearyl palmitate, stearyl stearate, stearyl isostearate, stearyl oleate, stearyl behenate, stearyl erucate, isostearyl myristate, isostearyl palmitate, isostearyl stearate, isostearyl isostearate, isostearyl oleate, isostearyl behenate, isostearyl oleate, oleyl myristate, oleyl palmitate, oleyl stearate, oleyl isostearate, oleyl oleate, oleyl behenate, oleyl erucate, behenyl myristate, behenyl palmitate, behenyl stearate, behenyl isostearate, behenyl oleate, behenyl behenate, behenyl erucate, erucyl myristate, erucyl palmitate, erucyl stearate, erucyl isostearate, erucyl oleate, erucyl behenate, Dicaprylyl carbonate, and erucyl erucate, ethers, more preferably selected from the group consisting of PPG-3 myristyl ether, PPG-11 stearyl ether, PPG-15 stearyl ether, PPG-14 butyl ether, and dicaprylyl ether, siloxanes and silanes, more preferably selected from the group consisting of dimethicone, PEG-14 dimethicone, PEG / PPG-14 / 4 dimethicone, Cetyl PEG / PPG- 10 / 1 Dimethicone and PEG / PPG-4 / 12 dimethicone, waxes, more preferably selected from the group consisting of cera alba (beeswax), copernicia cerifera (carnauba) wax, glyceryl rosinate, rhus verniciflua peel cera, euphorbia cerifera (candelilla) wax, hydrolyzed sunflower seed wax, jasminum officinale (jasmine) flower wax, acacia decurrens flower wax, myrica cerifera (bayberry) fruit wax, citrus aurantium dulcis (orange) peel wax, hydrogenated rapeseed oil, oryza sative (rice) bran wax, camellia sinensis leaf wax, vitis vinifera (grape) leaf wax, saccharum officinarum (sugarcane) wax, microcrystalline wax, lanolin (wool) wax, paraffin, synthetic wax, ozocerite, and hydrogenated jojoba, naphthenic hydrocarbons, more preferably selected from the group consisting of squalene, dialkylcyclohexanes, tetradecane, isohexadecane, dodecane, docosane, paraffin, and mineral oils, natural fats and oils including plant oils, preferably selected from the group consisting of caprylic / capric triglyceride, argania spinose kernel oil, cannabis sativa seed oil, ricinus communis (castor) seed oil, sesamum indicum (sesame) seed oil, crambe abyssinica seed oil, and triheptanoin castoryl maleateAbies Alba Seed Oil, Acacia Victoriae Seed Oil, Actinidia Chinensis (Kiwi) Seed Oil, Amaranthus Hypochondriacus Seed Oil, Simmondsia Chinensis (Jojoba) Seed Oil, Arachis Hypogaea (Peanut) Oil, Astrocaryum Murumuru Seed Butter, Astrocaryum Tucuma Seed Butter, Astrocaryum Tucuma Seed Oil, Astrocaryum Vulgare Fruit Oil, Astrocaryum Vulgare Kernel Oil, Avena Sativa (Oat) Kernel Oil, Brassica Alba Seed Oil, Brassica Campestris (Rapeseed) Seed Oil, Butyrospermum Parkii (Shea) Oil, Butyrospermum Parkii (Shea) butter, Calendula Officinalis Seed Oil, Calophyllum Inophyllum Seed Oil, Calophyllum Tacamahaca Seed Oil, Camellia Oleifera Seed Oil, Camellia Reticulata Seed Oil, Camellia Sinensis Seed Oil, Cannabis Sativa Seed Oil, Cannabis Sativa Seed / Stem Oil, Canola Oil, Carthamus Tinctorius (Safflower) Seed Oil, Chlorella Vulgaris Oil, Citrullus Lanatus (Watermelon) Seed Oil, Citrus Aurantifolia (Lime) Seed Oil, Citrus Aurantium Dulcis (Orange) Seed Oil, Citrus Grandis (Grapefruit) Seed Oil, Cocos Nucifera (Coconut) Oil, Cocos Nucifera (Coconut) Seed Butter, Coffea Arabica (Coffee) Seed Oil, Chlorella Oil (biotech), Corylus Americana (Hazelnut) Seed Oil, Corylus Avellana (Hazelnut) Seed Oil, Cucumis Melo (Melon) Seed Oil, Cucumis Sativus (Cucumber) Seed Oil, Cucurbita Pepo (Pumpkin) Seed Oil, Elaeis Guineensis (Palm) Oil, Elaeis (Palm) Fruit Oil, Glycine Soja (Soybean) Oil, Gossypium Herbaceum (Cotton) Seed Oil, Gossypium Hirsutum (Cotton) Seed Oil, Helianthus Annuus (Sunflower) Seed Oil, Macadamia Integrifolia Seed Oil, Macadamia Ternifolia Seed Oil, Mangifera Indica (Mango) Seed Butter, Mangifera Indica (Mango) Seed Oil, Melissa Officinalis Seed Oil, Microalgae Oil, Moringa Oleifera Seed Oil, Moringa Peregrina Seed Oil, Oenothera Biennis (Evening Primrose) Oil, Olea Europaea (Olive) Fruit Oil, Olus Oil, Orbignya Oleifera Seed Oil, Orbignya Speciosa Kernel Oil, Oryza Sativa (Rice) Bran / Germ Oil, Oryza Sativa (Rice) Bran Oil, Oryza Sativa (Rice) Germ Oil, Oryza Sativa (Rice) Lipids, Oryza Sativa (Rice) Seed Oil, Papaver Somniferum Seed Oil, Passiflora Edulis Seed Oil, Persea Gratissima (Avocado) Butter, Persea Gratissima (Avocado) Oil, Prunus Amygdalus Dulcis (Sweet Almond) Oil, Prunus Armeniaca (Apricot) Kernel Oil, Prunus Persica (Peach) Kernel Oil, Punica Granatum Seed Oil, Pyrus Malus (Apple) Seed Oil, Ricinoleic / Caproic / Caprylic / Capric Trig lyce rid e(s), Ricinus Communis (Castor) Seed Oil, Rosa Canina Fruit Oil, Rosa Moschata Seed Oil, Rubus Idaeus (Raspberry) Seed Oil, Sesamum Indicum (Sesame) Seed Butter, Soybean Glycerides, Theobroma Cacao (Cocoa) Seed Butter, Theobroma Grandiflorum Seed Butter, Triticum Vulgare (Wheat) Bran Lipids, Triticum Vulgare (Wheat) Germ Oil, Vitis Vinifera (Grape) Seed Oil, Zea Mays (Corn) Germ Oil, and Zea Mays (Corn) Oil, fatty alcohols and alcohols, preferably selected from the group consisting of octyldodecanol, isocetyl alcohol, cetyl alcohol, stearyl alcohol, and cetearyl alcohol, and glyceryl esters and derivatives thereof, more preferably selected from the group consisting of PEG-7 glyceryl cocoate, PEG-6 caprylic / capric glycerides, polyglyceryl- 3-caprate, polyglyceryl-4-caprate, PEG-5 bertholletia excelsa seed oily glyceryl esters, PEG-7 carapa guianensis glyceryl esters, PEG-7 caprylic / capric glycerides, PEG-7 theobroma grandiflorum seed butter glyceryl esters, cocoglycerides, glyceryl caprylate / caprate, glyceryl caprlyate glyceryl oleate, glyceryl undecylenate, polyglyceryl-2 caprate, polyglyceryl-4 cocoate, polyglyceryl-3 diisostearate, and PEG-10 olive glycerides. Most preferred esters as oil component include cetearyl nonanoate, propanediol caprylate, myristyl myristate, ethylhexyl stearate, C12-15 alkyl benzoate, isopropyl palmitate, isopropyl myristate, decyl cocoate, cetearyl ethylhexanoate, ethylhexyl palmitate, hexyl laurate, coco-caprylate / caprate, and caprylyl caprylate.

[0183] Most preferred ethers as oil component include dicaprylyl ether.

[0184] Most preferred siloxanes and silanes as oil component include dimethicone.

[0185] Most preferred waxes as oil component include cera alba (beeswax), copernicia cerifera (carnauba) wax, glyceryl rosinate, euphorbia cerifera (candelilla) wax, hydrolyzed sunflower seed wax, hydrogenated rapeseed oil, microcrystalline wax, lanolin (wool) wax, hydrogenated jojoba, isohexadecane.

[0186] Most preferred natural fats and oils as oil component include caprylic / capric triglyceride, argania spinose kernel oil, ricinus communis (castor) seed oil, Simmondsia Chinensis (Jojoba) Seed Oil, Butyrospermum Parkii (Shea) butter, Cocos Nucifera (Coconut) Oil, Glycine Soja (Soybean) Oil, Melianthus Annuus (Sunflower) Seed Oil, Olea Europaea (Olive) Fruit Oil, Persea Gratissima (Avocado) Oil, Prunus Amygdalus Dulcis (Sweet Almond) Oil, Theobroma Cacao (Cocoa) Seed Butter, Vitis Vinifera (Grape) Seed Oil.

[0187] The oil component may be a single substance or a combination of two or more substances.

[0188] In another preferred variant, the formulation according to the present invention is in the form of an aqueous or aqueous / alcoholic, preferably aqueous / ethanolic, or aqueous / glycolic based solution. Typically, this could be glycerin in water compositions.

[0189] As mentioned above, the formulation of the invention may further include one or more active substances, one or more adjuvants, one or more additives, and / or one or more auxiliary compounds. Auxiliary compounds, as understood herein, are supplementary ingredients that enhance the performance, stability, or appeal of the cosmetic formulation, but are not the main active ingredients. While the primary actives provide the main benefit (e.g., moisturizing, anti-aging), auxiliary compounds assist in various ways, such as providing stabilization (they ensure the formulation stays homogenous and effective over time), aesthetic enhancement (improve texture, feel, color, and / or scent to make the formulation more appealing), protection (some provide preservative functions or protect against UV damage and oxidation), functional support (they help in better application and absorption of the main active ingredients). Within the framework of the present invention, the active substance(s), adjuvant(s), additive(s), and / or auxiliary compound(s) may be selected among abrasives, agents against ageing of the skin, anti-cellulitis agents, antioxidants, astringents, odor absorbers, perspiration-inhibiting agents, anti-statics, binders, buffers, carrier materials, chelating agents, cell stimulants, depilatory agents, surface-active substances, deodorizing agents, antiperspirants, softeners, emulsifiers, enzymes, enzyme inhibitors, essential oils, fibers, film-forming agents, fixatives, foamforming agents, foam stabilizers, substances for preventing foaming, foam boosters, gelling agents, gel-forming agents, haircare agents, hair-setting agents, hair-straightening agents, bleaching agents, strengthening agents, stain-removing agents, optically brightening agents, impregnating agents, dirt-repellent agents, dyes, friction-reducing agents, lubricants, opacifying agents, plasticizing agents, covering agents, polish, preservatives, gloss agents, green and synthetic polymers, powders, proteins, re-oiling agents, abrasives, silicones, skin-soothing agents, skin care agents, skin-healing agents, skin lightening agents, skin-protecting agents, skin-softening agents, hair promotion agents, warming agents, skin-warming agents, stabilizers, surfactants, UV-absorbing agents, UV filters, primary sun protection factors, secondary sun protection factors, detergents, fabric conditioning agents, suspending agents, skin-tanning agents, actives modulating skin or hair pigmentation, matrix-metalloproteinase inhibitors, glycosaminoglycan stimulators, TRPV1 antagonists, desquamating agents, anti-cellulite agents or fat enhancing agents, hair growth activators or inhibitors, anti-acne agents, agents against ageing of the skin, anti-dandruff agents, anti-inflammatory agents, (further) anti-microbial agents, irritationpreventing agents, irritation-inhibiting agents, astringents, odor absorbers, perspirationinhibiting agents, antiseptic agents, cell stimulants, cleansing agents, depilatory agents, surface-active substances, deodorizing agents, antiperspirants, enzymes, enzyme inhibitors, hair care agents, hair-setting agents, hair-straightening agents, moisturedonating agents, moisturizing substances, moisture-retaining substances, bleaching agents, strengthening agents, stain-removing agents, optically brightening agents, impregnating agents, dirt-repellent agents, dyes, friction-reducing agents, lubricants, moisturizing creams, ointments, opacifying agents, covering agents, polish, gloss agents, green and synthetic polymers, powders, proteins, re-oiling agents, skin-cleansing agents, cooling agents, skin-cooling agents, fabric conditioning agents, vitamins, oils, waxes, pearlizing waxes, fats, phospholipids, saturated fatty acids, mono- or polyunsaturated fatty acids, a-hydroxy acids, polyhydroxy fatty acids, liquefiers, dyestuffs, color-protecting agents, pigments, anti-corrosives, fragrances or perfume oils, aromas, flavoring substances, odoriferous substances, polyols, electrolytes, organic solvents, and mixtures of two or more of the aforementioned substances, as further described below.

[0190] Among the aforementioned compounds preferred are agents against ageing of the skin, antioxidants, chelating agents, emulsifiers, surfactants, preservatives, green and synthetic polymers, rheology additives, oils, fragrances or perfume oils, polyols, and mixtures of two or more of the aforementioned agents.

[0191] Additional active compounds that may be included in the formulations of the invention are selected from the group consisting of abrasives, agents against ageing of the skin, anticellulitis agents, anti-dandruff agents, anti-inflammatory agents, anti-microbial agents, irritation-preventing agents, irritation-inhibiting agents, antioxidants, astringents, odor absorbers, perspiration-inhibiting agents, antiseptic agents, cell stimulants, cleansing agents, depilatory agents, surface-active substances, deodorizing agents, antiperspirants, enzymes, enzyme inhibitors, hair care agents, hair-setting agents, hair-straightening agents, moisture-donating agents, moisturizing substances, moisture-retaining substances, bleaching agents, strengthening agents, stain-removing agents, optically brightening agents, impregnating agents, dirt-repellent agents, dyes, friction-reducing agents, lubricants, moisturizing creams, ointments, opacifying agents, covering agents, polish, gloss agents, green and synthetic polymers, powders, proteins, re-oiling agents, abrading agents, silicones, skin-soothing agents, skin-cleansing agents, skin care agents, skin-healing agents, skin-lightening agents, skin-protecting agents, skin-softening agents, hair promotion agents, cooling agents, skin-cooling agents, warming agents, skin-warming agents, stabilizers, surfactants, UV-absorbing agents, UV filters, primary sun protection factors, secondary sun protection factors, detergents, fabric conditioning agents, suspending agents, skin-tanning agents, actives modulating skin or hair pigmentation, matrix-metalloproteinase inhibitors, skin moisturizing agents, glycosaminoglycan stimulators, TRPV1 antagonists, desquamating agents, anti-cellulite agents or fat enhancing agents, hair growth activators or inhibitors, vitamins, oils, waxes, pearlizing waxes, fats, phospholipids, saturated fatty acids, mono- or polyunsaturated fatty acids, a- hydroxy acids, polyhydroxy fatty acids, liquefiers, dyestuffs, color-protecting agents, pigments, anti-corrosives, fragrances or perfume oils, aromas, flavoring substances, odoriferous substances, polyols, electrolytes, organic solvents, and mixtures of two or more of the aforementioned substances, as further described below.

[0192] A further aspect of the present invention pertains to a method of producing a formulation as disclosed herein, comprising the following steps:

[0193] (i) providing the mixture as disclosed herein or the compounds contained in the mixture,

[0194] (ii) providing one or more active compounds and / or one or more auxiliary compounds, and

[0195] (iii) mixing the mixture of (i), or the compounds thereof, with the compounds of (ii) to provide the formulation. As mentioned above, the formulation produced this way exhibits chelating properties due to presence of the compounds contained in the mixture of the invention. Moreover, the compounds contribute to this effect in a synergistic manner.

[0196] Therefore, another aspect of the invention relates to a method of conveying chelating properties to a formulation, or increasing chelating properties of a formulation, comprising

[0197] (i) providing the mixture as disclosed herein or the compounds contained in the mixture,

[0198] (ii) providing one or more active compounds and / or one or more auxiliary compounds, and

[0199] (iii) mixing the mixture of (i), or the compounds thereof, with the compounds of (ii) to provide the formulation with chelating properties or the formulation with increased chelating properties.

[0200] Yet a further aspect of the present invention relates to the use of a mixture of the invention, or the compounds contained in the mixture, as a chelating mixture in a formulation. The formulation is preferably a pharmaceutical, cosmetic, personal care, animal care or homecare formulation.

[0201] On the basis of the observation that the combination of compounds included in the mixture of the invention provides a synergistic efficacy with respect to the chelating effect, it shall be understood that, generally, features and embodiments described in conjunction with a specific aspect of the invention shall form corresponding features and embodiments of all other aspects, unless the context dictates otherwise.

[0202] In the following, the invention is explained in more detail with reference to representative examples and the drawings, which show:

[0203] Fig. 1 Fe2+chelating properties of pentylene glycol, maltol, and carnosine as compared to the corresponding combination thereof.

[0204] Fig. 2 Fe2+chelating properties of maltol, cinnamal, and carnosine as compared to the corresponding combination thereof.

[0205] Fig. 3 Fe2+chelating properties of pentylene glycol, maltol, and cinnamal as compared to the corresponding combination thereof.

[0206] Fig. 4 Dependency of Fe2+chelating properties of anisic acid concentration. Example:

[0207] A. Chelating properties of different ingredients and combinations thereof

[0208] The below listed ingredients were evaluated fortheir chelating properties in relation to the most common ions in formulation (Fe and Cu). Normally EDTA or other classic chelators are used in formulations.

[0209] 1 . Ingredients tested 2. Test design

[0210] Sample preparation was as follows. Stock solutions were prepared. The pH value of the solutions was adjusted to 6. Final concentrations were adjusted via dilution factor. Assays for cupric ions and ferrous ions were performed by using an Assay Kit ex Zen-Bio. In both cases EDTA served as a positive control capable of chelation the respective ions in a dose dependent manner. Both were endpoint assays measuring absorbance of the formed complex. The activity was determined as the percent of total Pyrocatechol Violet (Pycrocatecholsulfonphtalein, PV) (Cu) or 3-(2-Pyridyl)-5,6-diphenyl-1 ,2,4-tiazinep, p'disulfonic acid (Ferrozine) (Fe) I ion binding.

[0211] In the cupric ion assay, PV is able to form a complex with free cupric ions resulting in a chromophore with strong absorbance at 632nm. Compounds that are able to chelate Cu(ll) lowerthe amount of free Cu(ll) in solution, decreasing the PV-Cu(ll) complex concentration, which results in a loss of absorbance at 632nm.

[0212] The ferrous ion assay is based on the ability of Ferrozine to form a complex with free ferrous ions resulting in a chromophore with strong absorbance at 562nm. Compounds that are able to chelate Fe(ll) lower the amount of free Fe(ll) in solution, decreasing the Ferrozine- Fe(ll) complex concentration, which results in a loss of absorbance at 562nm.

[0213] While both cupric ions and ferrous ions have been used in orientation trials, the set of main experiments has been carried out with the ferrous ion assay. The results thereof are shown in the following:

[0214] 3. Results a) Synergistic effect for Pentylene Glycol + Maltol + Carnosine

[0215] For the combination pentylene glycol, maltol and carnosine a synergistic effect on the chelating properties has been found, which can be easily seen from Fig. 1. Note that in order to better see a synergism, the amount of pentylene glycol, maltol and carnosine in the mixture was chosen to be half of the concentration of the respective pure substance solution. Despite lowering the concentrations, the chelating activity of the mixture was higher than the sum of each compound (in double concentration) alone. Therefore, the synergistic effect would be more remarkable if equal concentrations had been compared. b) Effect for Maltol + Cinnamal + Carnosine

[0216] The mixture of maltol, carnosine and cinnamal was found to exhibit 94.6% chelating efficiency. Summing the respective chelating efficiency determined for each respective (pure) compound up gives 85,5%. Thus, the chealting effect of the mixture is synergistic. This can also be derived from Fig. 2. Maltol, cinnamal and carnosine act together in a synergistic manner in relation to the chelating properties. c) Effect for Maltol + Cinnamal + Pentylene Glycol The results are illustrated in Fig. 3 and the table below.

[0217] Once again, a strong synergism could be observed for the combination pentylene glycol, maltol and cinnamal. Note that the mixture contains half of the pentylene glycol included in the respective single substance solution. d) Chelating effect of anisic acid Tested at two different concentrations (A=50ppm, B=87.5ppm), anisic acid alone was found to have strong and concentration-dependent chelating properties (cf. Fig. 4). 4. Summary

[0218] In summary, synergistic effects have been observed for the following combinations:

[0219] - Maltol, Carnosine, Pentylene Glycol;

[0220] - Maltol, Carnosine, Cinnamal; and - Maltol, Cinnamal, Pentylene Glycol.

[0221] Dose dependent chelating properties of Anisic Acid could be observed.

[0222] Similar synergistic results have been achieved for combinations of maltol, cinnamal and hinokitiol, combinations of cinnamal, carnosine and pentylene glycol, as well as combinations similar to those presented and mentioned above in which the pentylene glycol was replaced by 1 ,2-hexanediol, 1 ,2-heptanediol, 1 ,2-octanediol, 1 ,2-nonanediol and 1 ,2- decanediol.

[0223] B. Formulation examples

[0224] Overview:

[0225] Formulations (compositions) - amounts are indicated as % by weight for all formulations.

[0226] 1. DEO 1 .1 Cool Relief Deo Plus .2 Antiperspirant / deodorant roll-on . GEL .1 Frosty Facial Foam .2 Biotic Acne Control Gel

[0227] . Shampoo .1 Fresh Hair shampoo 3.2 Sulfate-free shampoo . Conditioner .1 Anti-itch hair conditioner, leave on .2 Hair Conditioner, Rinse-off . EMULSIONS .1 Essential Care Face& Body Cream 5.2 Antibacterial body lotion, sprayable

[0228] 5.3 Leave on w / o

[0229] Baby Erythema Cotton Cream .4 Sensitive Day Care Cream exp. SPF 15 .5 UV protection water spray SPF 50

[0230] 6. MASKS

[0231] Sheet mask- Ultra Calming

[0232] . Concentrate & Solid formulations: .1 Energy Concentrate

[0233] 7.2 Eye contour serum

[0234] 8. WIPES

[0235] Clear Anti Acne Wipe 9. Homecare

[0236] 9.1 All purpose cleaner

[0237] 9.2 Grapefruit Kitchen Cleaner

[0238] 9.3 High-performance HDWL with enzymes .4 Compact liquid detergent

Claims

Claims:

1. A mixture, blend or combination, comprising at least two, preferably at least three chosen from the following compounds:(A) a pyrone derivative,(B) a tropolone derivative,(C) a phenylpropanoid,(D) a monoterpene or monoterpenoid,(E) an aromatic acid or salt thereof,(F) a dipeptide, and(G) an alkanediol.

2. The mixture, blend or combination of claim 1 , wherein one or more of the following applies: compound A is a 3-hydroxy-4-pyrone, preferably maltol, compound B is hinokitiol, tropolone or thujaplicin, preferably hinokitiol, compound C is selected from the group consisting of cinnamal, eugenol, cinnamyl alcohol, isoeugenol, eugenol and flavonoids, preferably cinnamal or isoeugenol, most preferably cinnamal, compound D is selected from the group consisting of piperitone, citral, limonene, thymol and carvacrol, preferably piperitone or citral, compound E is a monobasic aromatic acid or salt, preferably anisic acid or a salt thereof, in particular p-anisic acid or a salt thereof, compound F is carnosine, compound G is a 1 ,2-alkanediol.

3. The mixture, blend or combination of claim 1 or 2, wherein one or more of the following applies:(i) a weight ratio of compound A to compound B ranges from 1 :1 to 1500:1 ,(ii) a weight ratio of compound A to compound C may range from 1 :2 to 1500:1 ,(iii) a weight ratio of compound B to compound C may range from 1 :100 to 50:1 ,(iv) a weight ratio of compound A to compound D ranges from 1 :30 to 150:1 ,(v) a weight ratio of compound C to compound D ranges from 1 :1500 to 10:1 ,(vi) a weight ratio of compound A to compound E ranges from 1 :16 to 75:1 ,(vii) a weight ratio of compound B to compound E ranges from 1 :800 to 2.5:1 ,(viii) a weight ratio of compound C to compound E ranges from 1 :800 to 5:1 ,(ix) a weight ratio of compound D to compound E ranges from 1 :80 to 75:1 ,(x) a weight ratio of compound A to compound F ranges from 1 :6 to 150:1 ,(xi) a weight ratio of compound C to compound F ranges from 1 :300 to 10:1 ,(xii) a weight ratio of compound E to compound F ranges from 1 :15 to 80:1 ,(xiii) a weight ratio of compound B to compound D ranges from 1 :1500 to 5:1 ,(xiv) a weight ratio of compound B to compound E ranges from 1 :800 to 2.5:1 ,(xv) a weight ratio of compound D to compound F ranges from 1 :30 to 150:1 ,(xvi) a weight ratio of compound A to compound G ranges from 1 :140 to 150:1 ,(xvii) a weight ratio of compound B to compound G ranges from 17000 to 5:1 , (xviii) a weight ratio of compound C to compound G ranges from 17000 to 10:1 ,(xix) a weight ratio of compound D to compound G ranges from 1700 to 150:1 ,(xx) a weight ratio of compound E to compound G ranges from 1 :350 to 80:1 ,(xxi) a weight ratio of compound F to compound G ranges from 1 00 to 30:1 .

4. The mixture, blend or combination of any of claims 1 to 3, which is acceptable for cosmetic, pharmaceutical, personal care, animal care or homecare formulations.

5. The mixture, blend or combination of any of claims 1 to 4, configured to exhibit chelating properties, preferably to a synergistic extent.

6. The mixture, blend or combination of any of claims 1 to 5, wherein all compounds present in the mixture, blend or combination occur in nature.

7. The mixture, blend or combination of any of claims 1 to 6, comprising one of the following combinations of compounds:(a) Maltol, hinokitiol and cinnamal,(b) Maltol, cinnamal and Carnosine,(c) Hinokitiol, cinnamal and Carnosine,(d) Hinokitiol, cinnamal and a 1 ,2-alkanediol, preferably 1 ,2-pentanediol,(e) Hinokitiol, Carnosine and a 1 ,2-alkanediol, preferably 1 ,2-pentanediol,(f) Maltol, hinokitiol and a 1 ,2-alkanediol, preferably 1 ,2-pentanediol,(g) cinnamal and hinokitiol,(h) any of the mixtures above in which the 1 ,2- alkanediol is selected from the group consisting of 1 ,2-hexanediol, 1 ,2-heptanediol, 1 ,2-octanediol, 1 ,2- nonanediol, 1 ,2-decanediol,(i) any of the mixtures above in which one of maltol, hinokitiol, cinnamal, carnosine and 1 ,2-pentanediol is replaced by anisic acid,(j) any of the mixtures above in which one of maltol, hinokitiol, cinnamal, carnosine and 1 ,2-pentanediol is replaced by piperitone.

8. A formulation comprising the mixture, blend or combination of any of claims 1 to 7, preferably wherein the formulation is selected from the group consisting of pharmaceutical, cosmetic, personal care, animal care and homecare formulations.

9. The formulation of claim 8, wherein, relative to the total weight of the formulation, one or more of the following applies: an amount of component A ranges from 0.05 to 1 .5 % by weight, relative to the total weight of the formulation, an amount of component B ranges from 0.001 to 0.05 % by weight, relative to the total weight of the formulation, an amount of component C ranges from 0.001 to 0.1 % by weight, relative to the total weight of the formulation, an amount of component D ranges from 0.01 to 1 .5 % by weight, relative to the total weight of the formulation, an amount of component E ranges from 0.01 to 1 .0 % by weight, relative to the total weight of the formulation, an amount of component F ranges from 0.01 to 0.3 % by weight, relative to the total weight of the formulation, an amount of component G ranges from 0.01 to 7.0 % by weight, relative to the total weight of the formulation.

10. The formulation of claim 8, wherein, relative to the total weight of the formulation, one or more of the following applies: an amount of component A ranges from 0.05 to 1 % by weight, preferably 0.1 to 0.7 % by weight, relative to the total weight of the formulation, an amount of component B ranges from 0.001 to 0.04 % by weight, preferably 0.001 to 0.03 % by weight, relative to the total weight of the formulation, an amount of component C ranges from 0.002 to 0.08 % by weight, preferably 0.005 to 0.05 % by weight, relative to the total weight of the formulation, an amount of component D ranges from 0.03 to 1.3 % by weight, preferably 0.05 to 1 .0 % by weight, relative to the total weight of the formulation, an amount of component E ranges from 0.02 to 0.8 % by weight, preferably 0.05 to 0.5 % by weight, relative to the total weight of the formulation. an amount of component F ranges from 0.015 to 0.25 % by weight, preferably 0.02 to 0.2 % by weight, relative to the total weight of the formulation, an amount of component G ranges from 0 0.05 to 6 % by weight, preferably 0.1 to 5 % by weight, relative to the total weight of the formulation.11 . The formulation of any of claims 8 to 10, wherein the formulation comprises one or more auxiliary compounds and / or one or more active compounds.

12. The formulation of any of claims 8 to 11 , wherein the formulation comprises a chelating agent different from the compounds chosen from compounds A, B, C, D, E, F and G.

13. A method of producing the formulation of any of claims 8 to 12, comprising:(i) providing the mixture, blend or combination of any of claims 1 to 7, or the compounds contained therein,(ii) providing one or more active compounds and / or one or more auxiliary compounds, and(iii) mixing the mixture, blend or combination of (i), or the compounds contained therein, with the compounds of (ii) to provide the formulation.

14. A method of conveying chelating properties to a formulation, or increasing chelating properties of a formulation, comprising(i) providing the mixture, blend or combination of any of claims 1 to 7, or the compounds contained therein,(ii) providing one or more active compounds and / or one or more auxiliary compounds, and(iii) mixing the mixture, blend or combination of (i), or the compounds contained therein, with the compounds of (ii) to provide the formulation with chelating properties or the formulation with increased chelating properties.

15. Use of a mixture, blend or combination of any of claims 1 to 7, or the compounds contained therein, or cinnamal and hinokitiol, as a chelating mixture, blend or combination in a pharmaceutical, cosmetic, personal care, animal care or homecare formulation.

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