9 results about "Plasma leakage" patented technology

This invention relates to a hydrogel-coated oxygenation membrane and its preparation method. A polyolefin resin and a modifier are added to a diluent, and the mixture is heated and stirred to obtain a casting solution. Using the casting solution as a raw material, a sheet membrane or hollow fiber membrane is obtained by thermally induced phase separation and film scraping or spinning. The hydrogel solution is irradiated under ultraviolet light to reach a semi-solid state, obtaining a prepolymerized hydrogel solution. The obtained prepolymerized hydrogel solution is coated onto the sheet membrane or hollow fiber membrane. The membrane coated with the prepolymerized hydrogel solution is then irradiated under ultraviolet light until the hydrogel solution is completely cured. After drying at room temperature, a hydrogel-coated oxygenation membrane is obtained, wherein the hydrogel layer thickness is 0.5-3 μm. The hydrogel-coated oxygenation membrane is used as a medium for blood gas exchange during extracorporeal membrane oxygenation (ECMO); the anti-plasma leakage time is 180-560 h, and the protein adhesion is 0.3-1.1 μg / cm³. 2 The hemolysis rate was 0.79-1.01%.

The invention provides a plasma processing device and a method for preventing plasma leakage, and the device comprises a reaction cavity which is internally provided with a pedestal used for bearing a wafer, and the pedestal is electrically connected with a first non-constant voltage power supply; the restraint ring is arranged on the periphery of the base in a surrounding mode, and the space in the reaction cavity is divided into a plasma processing area and an exhaust area communicated with an external vacuumizing device; the restraint ring is electrically connected with the second non-constant-voltage power supply; plasma is prevented from entering the exhaust area through the restraint ring. Even under the condition that the plasma density in the reaction cavity is high, the plasma leakage can be avoided, and the condition that the exhaust flow guide of the restraint ring meets the process requirement is ensured.

The application discloses an automatic positioning method for plasma leakage points in an eye fundus, and particularly relates to the technical field of medical image processing, and comprises five steps of coordinate extraction, coordinate conversion, data enhancement, initial positioning and accurate positioning. The YOLO model can be used to position key points in the leakage points with a time consumption of milliseconds, the coordinates of the key points are sent into the SAM model as prompt words, and the leakage point region is accurately segmented, the advantages of the YOLO model positioning quickly and the SAM model segmenting accurately are combined, the rapid positioning capacity of the YOLO model and the strong generalization capacity of the SAM model are utilized, and the rapid and accurate positioning of the plasma leakage points in the FFA image is realized in a segmentation mode.

The application provides a poly-4-methyl-1-pentene (PMP) membrane with a gradient pore structure and a preparation method thereof, which is suitable for an extracorporeal membrane oxygenator (ECMO). The PMP membrane is prepared by physical blending of PMP and polyvinylidene fluoride (PVDF) and multi-stage electrospinning process, and is formed into a composite membrane with an asymmetric gradient pore structure. The dense layer effectively inhibits plasma leakage, and the porous layer optimizes the gas exchange efficiency. The preparation method of the application is carried out at normal temperature and pressure, overcomes the limitation of high-temperature processing of traditional PMP membranes, and significantly improves the mechanical strength and gas permeability of the membrane. The PMP membrane has excellent biocompatibility, long-term stability and anti-plasma leakage performance, and can meet the long-term use requirement of ECMO, and provides a better solution for artificial lung membrane technology.

The invention provides a poly (4-methyl-1-pentene) (PMP) membrane with a gradient pore structure and a preparation method of the poly (4-methyl-1-pentene) membrane. The poly (4-methyl-1-pentene) membrane is suitable for an in-vitro membrane type artificial lung (ECMO). According to the PMP membrane, PMP and polyvinylidene fluoride (PVDF) are physically blended, multi-walled carbon nanotubes are combined for reinforcement, and the composite membrane with an asymmetric gradient pore structure is prepared through a multi-stage electrostatic spinning process. Wherein the compact layer effectively inhibits plasma leakage, and the porous layer optimizes the gas exchange efficiency. The preparation method is carried out at normal temperature and normal pressure, the limitation of high-temperature processing of a traditional PMP film is overcome, and meanwhile, the mechanical strength and the gas permeability of the film are remarkably improved. The PMP membrane has excellent biocompatibility, long-term stability and plasma leakage resistance, can meet the long-term use requirement of ECMO, and provides a better solution for an artificial lung membrane technology.

The present application relates to the technical field of membrane oxygenator products, and particularly relates to a membrane oxygenator plasma leakage testing device and a testing method thereof. The membrane oxygenator plasma leakage testing device comprises a gas supply device, a fluid circulation device, a condensation device, a leakage collection device and a weight measuring device. The gas supply device is connected to a gas inlet of the membrane oxygenator. The fluid circulation device is arranged outside the membrane oxygenator and connects a fluid inlet and a fluid outlet. The leakage collection device is connected to a gas outlet of the membrane oxygenator through the condensation device. The weight measuring device can measure the weight of the leakage amount of the leakage collection device. The membrane oxygenator plasma leakage testing device has simple components and simple connection relationship, and can be configured according to actual application scenarios.

The invention belongs to the field of biomedical materials, and discloses a composite oxygenation membrane with an active aldehyde removing function and a preparation method and application thereof. The composite oxygenation membrane is composed of a porous substrate, a polydimethylsiloxane compact layer and an active functional layer rich in primary amine groups. The polydimethylsiloxane compact layer is used for effectively blocking plasma leakage, and meanwhile excellent gas permeability is kept; the hyperbranched polyethyleneimine active functional layer rich in primary amine groups is utilized, and active aldehyde toxins such as malonaldehyde in blood are efficiently removed through Schiff base reaction. In addition, a hydration layer constructed on the surface of the composite oxygenation membrane remarkably improves the anti-pollution performance. The composite oxygenation membrane has the advantages of long-acting leakage resistance, active detoxification and excellent blood compatibility, and is suitable for preparing a high-performance ECMO oxygenation device.

A plasma confinement ring and a plasma processing apparatus are disclosed. The plasma confinement ring includes: a first confinement ring body; and a plurality of first gas channels penetrating the thickness of the first confinement ring body and arranged radially along the first confinement ring body. The material of the first confinement ring body includes p-type silicon. The plasma confinement ring can better confine plasma and reduce plasma leakage.

The invention relates to the field of membrane materials, and particularly discloses a zwitter-ion modified permeable membrane as well as a preparation method and application thereof. According to the multilayer gradient charge coating modified permeable membrane based on the TA / PEI / P (SBMA-co-AA), bionic anchoring is achieved through the TA-FeIII coordination layer, the stability is enhanced through covalent cross-linking of the PEI middle layer, the amphoteric ion copolymer P (SBMA-co-AA) on the outermost layer forms a strong hydration anti-fouling layer through a sulfobetaine unit, and the acrylic acid unit constructs the negative degree from a membrane body to the surface. The design synchronously realizes excellent protein adsorption resistance (protein adsorption is less than 5 mu g / cm), remarkably inhibits plasma leakage and has stable gas exchange performance, and the industrial problem that the blood compatibility and safety of the ECMO membrane material are difficult to synergistically improve is effectively solved.