36 results about "Thiophosphoric Acid Esters" patented technology

The invention relates to long-life turbine oil for an ammonia-resistant turboset and a preparation process of the long-life turbine oil. The complexing agent comprises an antioxidant, an anti-rust agent, an anti-wear reagent at extreme pressure, a metal deactivator, a demulsifier, an alkali-resistant stabilizer and base oil, the antioxidant comprises at least two of dinonyl diphenylamine, beta-(3, 5-di-tert-butyl-4-hydroxyphenyl) isooctyl propionate and dialkyl dithiocarbamate, the demulsifier comprises at least two of dialkyl dithiocarbamate, and the alkali-resistant stabilizer comprises at least two of dialkyl dithiocarbamate. The anti-wear reagent at extreme pressure comprises at least two of tricresyl phosphate, thiophosphate and amine salt derivatives thereof, and phosphate and amine salt derivatives thereof, and the alkali-resistant stabilizer comprises polycarboxylic polyether and aliphatic amines. The preparation method comprises the following steps: sequentially adding the components, heating, stirring, mixing at constant temperature, cooling and filtering.

The application belongs to the technical field of cutting oil, and specifically provides a kind of composite cutting oil and a preparation method thereof.A kind of composite cutting oil uses coconut oil, mineral oil, poly-alpha olefin as mixed base oil, adds specific amount of rust preventive, polyethylene glycol, nano molybdenum disulfide, antioxidant, dispersant and composite additive obtained by chemical combination of carboxylated multi-walled carbon nanotube surface and thiophosphate amine salt, etc., through the synergistic effect of multiple components, the prepared cutting oil has excellent lubricity, extreme pressure and wear resistance, and is suitable for severe extreme pressure cutting environment.

The invention discloses a graphene composite lubricating additive as well as a preparation method and application thereof, and belongs to the technical field of lubricating additive preparation. Modified graphene, nano molybdenum disulfide, a dispersing agent and thiophosphate amine salt are mixed and react to obtain the graphene composite lubricating additive. According to the invention, a triple synergistic stabilization mechanism of chemical anchoring, physical blocking and steric hindrance is utilized, so that the compatibility of graphene and base oil is improved, and the dispersion stability of the graphene composite lubricating additive is improved. Meanwhile, the prepared graphene composite lubricating additive can reduce the temperature of a friction pair, can form a friction reaction film containing C, Mo, P and O elements on the surface of the friction pair, reduces friction wear, shows good friction reduction and wear resistance, provides a theoretical basis and technical support for development of high-performance lubricating oil additives and application of high-temperature working conditions, and has wide application prospects. And the high-temperature lubrication problem of the marine diesel engine is solved, and remarkable engineering value and application prospects are achieved.

Provided is the use of two-dimensional nanomaterials in the inhibition of a coronavirus, and specifically disclosed is the use of the two-dimensional nanomaterials in the preparation of a medicament for treating or preventing diseases caused by a coronavirus or of a material for adhering to or inhibiting the coronavirus. The two-dimensional nanomaterial is selected from the group consisting of copper indium thiophosphate (CIPS) nanosheet, graphene oxide nanosheet, molybdenum disulfide nanosheet, black phosphorus nanosheet and mixtures thereof. The coronavirus is selected from one of HCoV-229E, HCoV-OC43, HCoV-NL63, HCoV-HKU1, SARS-CoV, SARS-CoV2 or MERS-CoV. The diseases caused by the coronavirus are diseases caused by coronavirus infection. The material has the advantages of being simple to prepare, having a high biological safety and an excellent effect.

The application belongs to the technical field of organic synthesis, and particularly relates to a kind of beta-carbonyl dithiophosphoric acid ester compounds, preparation method and application. The application is prepared by using cheap and easily available styrene, P4S 10 And alcohol as raw material, tetrabutylammonium tetrafluoroborate ( n Bu4NBF4) as electrolyte, acetonitrile (CH3CN) as solvent, beta-carbonyl dithiophosphoric acid ester compound is prepared in room temperature and air atmosphere. Compared with the preparation method reported previously, the application has the advantages of green, environmental protection, safety, high efficiency and energy saving, the raw material is easy to obtain, and the operation is simple, and has potential industrial application prospect.

The application relates to the field of cutting fluids, and discloses an inhibitor, a high-efficiency lubricating water-based cutting fluid and application thereof. A long-chain alkyl phosphate betaine is selected as a key inhibitor. Phosphate anions and quaternary ammonium salt cations in the molecule can be firmly adsorbed on metal surfaces with different electricities, and long-chain alkyls can form a dense hydrophobic layer on the metal surface, laying a foundation for multi-metal compatibility. The inhibitor has a synergistic effect with a semi-synthetic composite lubricating system. In addition, the system uses a thiophosphate and an organic phosphonic acid to be compounded as extreme pressure anti-wear agents. In the absence of chlorine and boron, the extreme pressure anti-wear agents can form a high-strength chemical reaction film with the above-mentioned adsorption film under extreme pressure conditions, so that the carrying capacity is further improved.

The invention relates to a double-stranded RNA conjugate and a preparation method and application thereof, the double-stranded RNA conjugate comprises a first nucleic acid molecule, a second nucleic acid molecule and a linker, the first nucleic acid molecule is connected with the second nucleic acid molecule through the linker, the linker is connected with the first nucleic acid molecule and the second nucleic acid molecule through phosphate (p) or thiophosphate (s), and the linker is connected with the first nucleic acid molecule and the second nucleic acid molecule through phosphate (p) or thiophosphate (s). The joint is selected from a structure as shown in a formula (I);

The present invention provides a stable composition comprising a nucleic acid oligomer having a phosphorothioate bond, a production method thereof, and an efficient production method of the aforementioned nucleic acid oligomer from the composition. The present invention provides a composition comprising an additive, the aforementioned additive comprising a nucleic acid oligomer having a phosphorothioate bond represented by formula (1) (in the formula, the symbols are the same as defined in the specification), an alkylammonium salt, a water-soluble organic solvent, water, and at least one compound described in the specification.

The invention discloses a method for preparing alkyl phosphorothioate through direct functionalization of a C-H bond, and belongs to the technical field of organic synthesis. The method comprises the following steps: adding a compound 1, a P (O) SH compound 2a, a photocatalyst, a copper catalyst and an oxidizing agent into a solvent, reacting in a protective atmosphere and under the irradiation of visible light, and after the reaction is completed, performing post-treatment to obtain the alkyl thiophosphate. The method for synthesizing the alkyl phosphorothioate through direct sulfur and phosphorus esterification of the C-H bond is a simple and efficient synthesis method. The method does not need to functionalize the raw materials in advance, greatly enriches product diversity, and has the characteristics of few steps, atom economy, simple operation and the like.

The invention relates to a preparation method of polyether modified silicone oil, which belongs to the technical field of polyether modified silicone oil, and comprises the following steps: carrying out reaction on octamethylcyclotetrasiloxane, fluorocyclosiloxane and polymethylhydrosiloxane to obtain low-hydrogen silicone oil; reacting low-hydrogen silicone oil with allyl polyether, silane grafted nanoparticles and glycidyl methacrylate to obtain a compound; and combining the compound with dialkyl dithiophosphate to obtain the polyether modified silicone oil. According to the technical scheme, octamethylcyclotetrasiloxane, fluorocyclosiloxane and polymethylhydrosiloxane are combined, so that the surface tension of polyether modified silicone oil can be remarkably reduced, and low-hydrogen silicone oil is combined with allyl polyether, silane grafted nanoparticles and glycidyl methacrylate, so that the surface tension of the polyether modified silicone oil is remarkably reduced. The thermal stability and wettability of the polyether modified silicone oil are improved, the defoaming performance and storage stability of the polyether modified silicone oil are further improved through the dialkyl dithiophosphate, and the comprehensive performance of the polyether modified silicone oil is overall improved.

The invention provides a central nervous system delivery structure as well as a conjugate, a preparation method and application thereof. The delivery structure is represented by L-R, where L is a lipophilic group and R is a group comprising a structure for covalent attachment to a nucleic acid molecule; the lipophilic group is selected from a saturated or unsaturated hydrocarbyl group, a saturated or unsaturated fatty acid, and a saturated or unsaturated fatty alcohol; the structure covalently linked with the nucleic acid molecule comprises an-O-group in a hydroxyl group, and is covalently linked with a phosphorothioate group or a phosphate group of the nucleic acid molecule through the-O-group; r at least comprises an optionally substituted cycloalkyl group, an optionally substituted heterocyclic group, an optionally substituted heteroaryl group or an optionally substituted aryl group. The delivery structure is high in delivery efficiency, low in toxicity and simple in preparation method.

The application relates to the field of lubricating oil, in particular to an antioxidant lubricating oil and a preparation method thereof. The lubricating oil comprises the following components in parts by weight: 80-90 parts of vegetable base oil, a forming additive; the forming additive comprises 3-6 parts of an antioxidant, 6-10 parts of a viscosity modifier, 2-5 parts of an anti-foaming agent and 2-5 parts of an anti-rust agent; the antioxidant comprises 40-60 wt% of p-diisooctyl diphenylamine, 20-30 wt% of a metal passivator, 5-8 wt% of a thiophosphate and the rest of mercaptan; the preparation method comprises pretreatment, one-step mixing and two-step mixing; the antioxidant of the application is prepared by compounding p-diisooctyl diphenylamine, a metal passivator, a thiophosphate and mercaptan, the antioxidant performance of the lubricating oil is greatly improved, and the problem that lubricating oil is difficult to stably lubricate in some lubricating operations with high humidity and long equipment running cycle is solved.

The present application relates to the technical field of shock absorber oil, and particularly relates to a long-life motorcycle shock absorber oil composition, a preparation method and application thereof. The shock absorber oil composition comprises the following components in percentage by weight: 0.4-4.7% of an anti-wear agent, 0.08-1.7% of an antioxidant; the anti-wear agent is a combination of butyl triphenyl phosphorothioate and a phosphorothioate complex ammonium salt; the antioxidant is a mixture of three components of alkyl diphenylamine, 2,6-di-tert-butyl mixed phenol and alkylated phenyl alpha-naphthylamine. The product has outstanding viscosity-temperature characteristics (a viscosity index greater than 150), excellent low-temperature performance (a pour point not higher than -45 DEG C without adding a pour point depressant), excellent friction-reducing and anti-wear performance, and good anti-oxidation and anti-rust performance. The product can be used for front and rear shock absorption of a motorcycle, and has a wide range of applications.

This invention discloses a highly efficient selective UV-absorbing film based on polyvinyl acetal and its preparation method, belonging to the technical field of polymer functional membrane materials. The UV-absorbing film comprises the following components in parts by weight: 55-95 parts of matrix resin, 5-45 parts of plasticizer, 0.005-1.2 parts of core UV absorber, 0.01-0.3 parts of auxiliary UV absorber, 0.01-0.8 parts of composite antioxidant, 0.01-0.8 parts of light stabilizer, and 0.0025-0.0065 parts of metal ion additive. The core UV absorber is an alkyl-modified benzoxazinone compound, and the composite antioxidant is a combination of a hindered phenolic resin as the main antioxidant and a thiophosphate ester as the auxiliary antioxidant. This invention achieves highly efficient blocking of UV-B radiation and high transmittance of UV-A radiation. Simultaneously, the film material has advantages such as low initial yellowing, excellent long-term anti-yellowing performance, good thermal stability, good compatibility with the matrix, and no exudation. The present invention also provides a method for preparing the core UV absorber and a method for preparing the membrane, which are simple processes and suitable for industrial production.

The disclosure relates to methods of operating transmissions and for providing bearing pitting protection and a passing static friction performance according to Caterpillar TO-4 SEQ 1221 in a transmission including lubricating the transmission with a transmission fluid composition comprising:greater than 50 wt. % of a base oil of lubricating viscosity;an amount of one or more overbased calcium sulfonate detergent(s) to provide from about 2000 ppm to about 5000 ppm of calcium;an amount of one or more zinc dialkyl dithiophosphate compound(s) to provide from about 700 ppm to about 1500 ppm of zinc; andan amount of one or more molybdenum-containing compound(s) to provide from about 5 ppmw to about 300 ppmw molybdenum, and the one or more molybdenum-containing compound(s) is selected from the group consisting of molybdenum dithiocarbamates, molybdenum phosphorodithioates, organomolybdenum complexes, molybdenum dialkyldithiophosphates and mixtures thereof. The disclosure also relates to the compositions used in these methods.

Provided are a novel nucleic acid oligomer and a method for producing the same.　The nucleic acid oligomer according to the present invention includes a nucleotide unit represented by general formula (1) and a nucleotide unit represented by general formula (2), and may or may not include a nucleotide unit represented by general formula (3). In general formulas (1), (2), and (3): R1 represents a hydrogen atom, a hydroxyl group, an alkoxy group, an alkenyloxy group, an acyloxy group, a trialkylsilyloxy group, an alkoxyalkoxy group, a haloalkoxyalkoxy group, or a halogenyl group, and R2 represents a hydrogen atom, or R1 and R2 bond together to form a five- or more-membered ring optionally having a substituent and optionally having a hetero atom; Bs represents a nucleobase selected from the group consisting of adenine, guanine, cytosine, 5-methylcytosine, thymine, and uracil, the nucleobase optionally having a nucleobase protecting group; and X+ represents a counter cation.

The invention discloses a preparation method of wear-resistant water-ethylene glycol flame-retardant hydraulic fluid, and belongs to the field of hydraulic oil. Comprising the following steps: step 1, slowly dropwise adding isooctanol into PSC13 at 0-5 DEG C, and reacting to obtain thiophosphate; 2, thiophosphate, polyether amine, a basic catalyst and methylbenzene are mixed, the temperature is increased, a reaction is conducted, aftertreatment is conducted, and thiophosphate complex ester amine salt is obtained; 3, mixing and dissolving a tackifier, water and ethylene glycol to obtain a basic solution; and step 4, mixing the thiophosphoric acid diester amine salt, the antirust agent, the defoaming agent and the basic liquid to obtain the wear-resistant water-ethylene glycol flame-retardant hydraulic fluid. A sulfur-phosphorus active center and a hydrophilic group which have a synergistic effect are constructed in molecules of the water-soluble thiophosphoric acid diester amine salt, so that the anti-wear agent can efficiently form a composite protective film in the friction process, and the extreme pressure anti-wear performance is remarkably improved.

This disclosure relates to the discovery of certain ashless antiwear additives in the form of dialkyl dithiophosphate triester compounds having specific oxygen ester moieties and specific sulfur ester moieties, which, in combination, provide antiwear additives that achieve lubricant performance without requiring (or having reduced levels of) the metals provided by more conventional metal-based antiwear additives. Therefore, the ashless antiwear additives of this disclosure can complement and / or replace conventional ZDDP additives used in lubricants, while still achieving the desired wear and durability performance targets in all types of automotive engines.

The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structurewherein:R1 and R2 are each independently for each occurrence optionally substituted C10-C30 alkyl, optionally substituted C10-C30 alkenyl, optionally substituted C10-C30 alkynyl, optionally substituted C10-C30 acyl, or -linker-ligand; R3 is H, optionally substituted C1-C10 alkyl, optionally substituted C2-C10 alkenyl, optionally substituted C2-C10 alkynyl, alkylhetrocycle, alkylphosphate, alkylphosphorothioate, alkylphosphorodithioate, alkylphosphonates, alkylamines, hydroxyalkyls, ω-aminoalkyls, ω-(substituted)aminoalkyls, ω-phosphoalkyls, ω-thiophosphoalkyls, optionally substituted polyethylene glycol (PEG, mw 100-40K), optionally substituted mPEG (mw 120-40K), heteroaryl, heterocycle, or linker-ligand; and E is C(O)O or OC(O).

The invention belongs to the technical field of cutting oil, and particularly provides composite cutting oil and a preparation method thereof. According to the composite cutting oil, coconut oil, mineral oil and poly-alpha olefin are used as mixed base oil, a specific amount of an anti-rust agent, polyethylene glycol, nano molybdenum disulfide, an antioxidant, a dispersing agent and auxiliary agents such as a composite additive obtained by chemically combining multi-walled carbon nanotubes with thiophosphate amine salt after the surfaces of the multi-walled carbon nanotubes are carboxylated are added, and the composite cutting oil is prepared through the synergistic effect of multiple components. The prepared cutting oil has excellent lubricity, extreme pressure property and wear resistance, and is suitable for severe extreme pressure cutting environments.

The application discloses a synthesis method of tris(4-aminophenyl) thiophosphate, and belongs to the technical field of chemical synthesis, characterized by comprising the following steps: placing tris(4-nitrophenyl) thiophosphate, a catalyst and a solvent in a high-pressure reaction kettle, filling hydrogen gas with a pressure of 1.0-2.5 MPa, reacting at 50-70 DEG C for 1-2 h, sampling after being cooled to room temperature, removing the catalyst through centrifugation, and obtaining the product tris(4-aminophenyl) thiophosphate; the catalyst is a bimetallic doped platinum carbon supported catalyst, and the doped active metal is selected from any two of Al, Cu or Zn; the synthesis method of tris(4-aminophenyl) thiophosphate is characterized by adopting a novel bimetallic doped platinum carbon catalyst to catalyze the reaction, simultaneously controlling the reaction pressure and reaction time, effectively improving the conversion rate of the catalytic reduction reaction, and the catalyst is not easy to be poisoned in the reaction process.

The application relates to the technical field of batteries, in particular to an electrolyte and a battery; the electrolyte comprises an organic solvent, a lithium salt and an additive, the additive comprises a first additive; the first additive comprises a silicon-based sulfonate compound and a thiophosphate compound, the silicon-based sulfonate compound has a structure shown in formula I, and the thiophosphate compound has a structure shown in formula II: formula I; formula II. Compared with the prior art, the application adds the additive containing the silicon-based sulfonate compound and the thiophosphate compound, improves the stability and ion conductivity of an interface film, and significantly improves the cycle life, high-temperature performance and low-temperature performance of a high-voltage lithium ion battery.

The invention relates to the technical field of micro-pitting repair, in particular to a micro-pitting repair additive as well as a preparation method and application thereof. The micro pitting corrosion repairing additive provided by the invention is layered silicate non-covalently modified by ionic liquid; the ionic liquid is one or more of phosphate ammonium salt, thiophosphate ammonium salt and phosphate phosphonium salt. The micro-pitting repair additive provided by the invention has a good repair effect on formed micro-pitting, can realize online repair, does not need to stop, and saves the cost.

The invention relates to the field of cutting fluid, and discloses a corrosion inhibitor, an efficient lubricating water-based cutting fluid and application of the corrosion inhibitor, long-chain alkyl phosphate betaine is selected as a key corrosion inhibitor, phosphate anions and quaternary ammonium salt cations in molecules of the long-chain alkyl phosphate betaine can be firmly adsorbed on metal surfaces with different electrical properties, and the metal surfaces with different electrical properties can be formed. And long-chain alkyl can form a compact hydrophobic layer on the metal surface, so that a foundation is laid for multi-metal compatibility. The corrosion inhibitor disclosed by the invention and a semi-synthetic composite lubricating system have a synergistic interaction effect. Besides, thiophosphate and organic phosphonic acid are compounded to serve as an anti-wear reagent at extreme pressure in the system, and the anti-wear reagent and the adsorption film can form a high-strength chemical reaction film under the extreme pressure condition under the condition that chlorine and boron are not contained, so that the bearing capacity is further improved.

PROBLEM TO BE SOLVED: To provide a grease composition which exhibits excellent friction and wear resistance characteristics and realizes a long service life even in high-temperature and high-speed-rotation environments. SOLUTION: A grease composition containing a synthetic hydrocarbon oil, a urea-based thickener, and an extreme pressure additive, in which the extreme pressure additive is at least one selected from the group consisting of alkenyl acid phosphates and trialkyl trithiophosphites and the grease composition is free from metal stearates and amide compounds.

In some embodiments, the present disclosure is directed to compositions and methods of reducing conversion of phosphorothioate bonds during the synthesis and storage of oligonucleotides. In some related embodiments, the present disclosure is directed to compositions and methods of reducing conversion of thio-NTPs. In some embodiments, the methods or compositions of the present disclosure find use in reducing phosphorothioate to phosphodiester impurities in an oligonucleotide or therapeutic oligonucleotide.

The invention relates to the technical field of lubricating oil preparation, and particularly discloses a preparation process of a lubricating oil composition containing a low-temperature enhanced molybdenum additive, which comprises the following steps: S1, mixing molybdic acid and docosyl thiophosphate ligand under the protection of nitrogen for in-situ synthesis of the low-temperature enhanced molybdenum additive to obtain an in-situ synthesized molybdenum-ligand compound; s2, a molybdenum nano dispersion with the particle size being 50-100 nm is obtained; s3, obtaining a pre-dispersed oil phase; s4, obtaining a modified oil phase; s5, obtaining a mixed oil phase; and S6, obtaining the final lubricating oil composition containing the low-temperature enhanced molybdenum additive. According to the low-temperature enhanced molybdenum additive disclosed by the invention, the molybdenum active component is highly dispersed and stable in a low-temperature environment through a fine in-situ complexing synthesis and nano-scale dispersion technology, and cannot be gathered or precipitated due to temperature drop, so that the pour point of lubricating oil is remarkably reduced, the pumpability and fluidity of an oil product at an extremely low temperature are improved, and the service life of the lubricating oil product is prolonged. And smooth starting and operation of the engine and mechanical equipment under severe cold conditions can be ensured.

The present invention relates to a chlorpyrifos hapten, an artificial antigen, a monoclonal antibody, and a preparation method and application thereof. The chemical structural formula of the chlorpyrifos hapten is: #imgabs0#. The preparation steps are as follows: 3,5,6-trichloropyridine-2-ol and ethyl thiophosphoryl dichloride react to obtain compound C; compound C reacts with ethyl 3-hydroxy-2-(hydroxymethyl)propionate to obtain compound E; and compound E is hydrolyzed under alkaline conditions to obtain the chlorpyrifos hapten. The chlorpyrifos hapten of the present invention not only contains two complete chlorpyrifos structures in each molecule, but also completely retains the characteristic groups of trichloro-2-pyridine and thiophosphorothioate in the chlorpyrifos molecule, so that the electron cloud density between the prepared hapten and the original drug is the same; at the same time, the prepared artificial antigen also enables the small molecule to have a more prominent spatial structure in the carrier protein, thereby improving the immunogenicity of the antigen.

To provide a lubricant composition and a method for lubricating an engine, which are effective in reducing high-temperature deposits, particularly those present in low-ash compositions.SOLUTION: A lubricant composition comprises at least one base oil of lubricating viscosity, a detergent system, and an antiwear system comprising a metal dialkyldithiophosphate that provides phosphorus to the lubricant composition. A total base number (TBN) of the lubricant composition is about 0.5 to about 20 and the amount of the phosphorus from the antiwear system relative to the TBN of the lubricant composition is 150 or less.SELECTED DRAWING: None