Phage therapy

Abstract

The present invention relates to phage therapy. More specifically, the present invention relates to novel phages with high specificity for Staphylococcus aureus strains, their manufacture, their components, compositions comprising them, and their use in phage therapy and as companion diagnostics.

Description

[0001] This application is a divisional application of the application filed on March 7, 2018, with international application number PCT / EP2018 / 055629, which entered the Chinese national phase on September 9, 2019, with application number 201880016793.2 and invention title "phage therapy". Technical Field

[0002] This invention relates to novel bacteriophage compositions, their manufacture, and their uses. The invention is particularly suitable for treating infections in humans and animals. Background Technology

[0003] Bacteriophages are small viruses that exhibit the ability to infect and kill bacteria without affecting cells from other organisms. First described by William Twort a century ago and independently discovered shortly thereafter by Félix d'Herelle, over 6,000 different bacteriophages have been identified and morphologically described to date, including viruses of bacteria and archaea. The vast majority of these viruses are tailed, while a smaller number are polyhedral, filamentous, or pleomorphic. They can be classified according to their morphology, genetic contents (DNA or RNA), specific host, habitat (marine or other habitats), and life cycle. As intracellular parasites of bacterial cells, bacteriophages exhibit different life cycles within their bacterial hosts: lytic, lysogenic, and pseudolysogenic (Weinbauer, 2004; Drulis-Kawa, 2012). As a normal part of their life cycle, lytic bacteriophages cause lysis of the host bacterial cell. Lysogenic phages (also known as temperate phages) can replicate using a lytic life cycle and cause lysis of host bacteria, or they can incorporate their DNA into the host bacterial DNA and become non-infectious prephages. Pseudolysogenicity can be defined as a developmental arrest phase in which a phage does not proliferate or replicate in the host cell (M...). (2012). Regardless of the phage cycle type, the first step is attachment to receptors on the bacterial cell wall, after which the phage's genetic material can enter the bacteria. This specific process defines the spectrum of bacteria that interact with phages.

[0004] Bacteriophages are often used as research tools to improve bacteria in laboratory experiments.

[0005] Due to their target host cell specificity, bacteriophages have been considered for use as a therapy to treat acute and chronic infections, particularly in dermatology, ophthalmology, urology, dentistry, pediatrics, otolaryngology, or surgery. However, the concept of this therapeutic use of bacteriophages for bacterial infections has been highly controversial from the outset and has not been widely accepted by the public or the medical community. Early studies were widely criticized for the lack of suitable controls and inconsistent results. The lack of reproducibility and numerous conflicting results obtained in various published studies led the Council on Pharmacy and Chemistry of the American Medical Association to conclude that the evidence regarding the therapeutic value of lysate filtrate was largely contradictory and unconvincing, and recommended further research to confirm its claimed benefits.

[0006] Since the introduction of antibiotics in the 1940s, this field of therapeutics has received little attention, particularly in the Western world. However, the widespread use of antibiotics has led to the proliferation of antibiotic-resistant bacteria worldwide, causing increasingly serious problems. Therefore, overcoming the limited remaining treatment options still available for treating major multidrug-resistant microorganisms has become a major challenge.

[0007] Staphylococcus aureus (S. aureus) is a Gram-positive coccus that is commonly found in the nose, respiratory tract, and on the skin. Staphylococcus aureus is distinguished from other staphylococcal species by its aureus colony pigmentation and positive results in coagulase, mannitol fermentation, and deoxyribonuclease tests. Staphylococcus aureus is one of the most important pathogens worldwide and has become a significant organism infecting critically ill patients.

[0008] Staphylococcus aureus (S. aureus) can be a commensal but also a dangerous pathogen. Approximately 30% of the population is colonized by S. aureus. S. aureus infection is a leading cause of skin, soft tissue, respiratory, bone, joint, and vascular diseases such as skin abscesses, wound infections, endocarditis, osteomyelitis, pneumonia, and toxic shock syndrome. S. aureus is particularly adept at infecting foreign objects in the human host. In these cases, S. aureus typically forms a biofilm on the surface of foreign devices (e.g., implantable cardiac devices, vascular catheters, prostheses, stents, etc.), making eradication of the infection virtually impossible without surgical removal of the device. S. aureus can adapt to living inside cells, where it is protected from host defense mechanisms and most antibiotics.

[0009] The number of staphylococcal infections continues to rise, and these infections are becoming even more difficult to treat due to the emergence of multidrug-resistant staphylococcal strains, including methicillin and vancomycin. In the United States and the United Kingdom, 40% to 60% of hospital-acquired Staphylococcus aureus strains are multidrug-resistant.

[0010] Therefore, there is a great need for new antibacterial agents or compositions that can be used to destroy or control Staphylococcus aureus strains, suitable for use in human or animal therapies, and suitable for the disinfection of materials.

[0011] Experimental phage therapies against Staphylococcus aureus have been tested in mice (Capparelli et al., 2007) but have not yet been developed for human use. Therefore, given the high potential for Staphylococcus aureus to acquire resistance, there is a need for novel antibacterial agents or compositions that can be used to kill Staphylococcus aureus strains, including the troublesome methicillin-resistant strains (MRSA). Summary of the Invention

[0012] The inventors have isolated and characterized novel bacteriophages that exhibit strong lytic activity against Staphylococcus aureus strains. These bacteriophages, alone or in combination, provide very strong antibacterial effects and can be used as active agents in pharmaceutical or veterinary preparations, particularly for the treatment of Staphylococcus aureus infections.

[0013] One object of the present invention is to provide an antibacterial composition comprising at least one bacteriophage having lytic activity against at least one strain of Staphylococcus aureus, said at least one bacteriophage being selected from bacteriophages having a genome having a nucleotide sequence comprising any one of SEQ ID NO: 1 to 4 or a sequence having at least 90% identity with it.

[0014] Another object of the present invention relates to a bacteriophage that has lytic activity against Staphylococcus aureus strains and has a genome comprising a nucleotide sequence selected from any one of SEQ ID NO: 1 to 4 or a sequence having at least 95% identity with it.

[0015] The present invention also relates to isolated nucleic acid molecules contained in the bacteriophages of the present invention, preferably isolated nucleic acid molecules comprising a nucleotide sequence selected from any one of SEQ ID NO: 1 to 4 or a sequence having at least 95% identity with it, and isolated polypeptides encoded by said nucleic acid.

[0016] Another object of the present invention is a composition comprising nucleic acids or polypeptides as defined above.

[0017] The compositions of the present invention typically also contain pharmaceutically or veterinarily applicable excipients or carriers. These may be liquid, semi-liquid, solid, or lyophilized.

[0018] Another object of the present invention relates to bacteriophages, nucleic acids, polypeptides or compositions as defined above, for the treatment of infections in humans and animals, for the modification of the microbial flora of said humans or animals, for the sterilization of materials, for the killing or control of Staphylococcus aureus bacteria, and / or for impairing the integrity of bacterial biofilms produced by Staphylococcus aureus bacteria, and / or for the sterilization of food and beverages.

[0019] The present invention also relates to bacteriophages, nucleic acids, polypeptides, or compositions as defined above, for improving the condition of a subject by modifying the microbial community within the subject. The microbial community can be improved by correcting, altering, or restoring an appropriate balance of microorganisms within the community.

[0020] The present invention also relates to a method for treating an infection in a human or animal, the method comprising administering to the human or animal at least one phage, nucleic acid, polypeptide, or composition as defined above.

[0021] The present invention also relates to a method for treating a surface or material suspected of being contaminated with Staphylococcus aureus bacteria, the method comprising applying to the surface or material at least one bacteriophage, nucleic acid, polypeptide, or composition as defined above. The surface or material can be the surface of any device, container, laboratory material, clothing, footwear, military equipment, air cooling system, residence, etc.

[0022] Another object of the present invention relates to a kit comprising a composition as defined above and a tool for applying the composition to an object or surface.

[0023] This invention can be used on or in any human or animal (preferably human) or in any human or animal (preferably human), or for handling any material, including laboratory materials or medical devices inside or outside a human or animal.

[0024] Another object of the present invention relates to a method for determining a mixture of bacteriophages effective against a target strain of Staphylococcus aureus, the method comprising:

[0025] a) Contact the targeted Staphylococcus aureus strain or a sample containing the strain separately with the following phages: (i) a phage having a genome containing the nucleotide sequence of SEQ ID NO: 1 or a sequence having at least 90% identity with it, and / or (ii) a phage having a genome containing the nucleotide sequence of SEQ ID NO: 2 or a sequence having at least 90% identity with it, and / or (iii) a phage having a genome containing the nucleotide sequence of SEQ ID NO: 3 or a sequence having at least 90% identity with it, and / or (iv) a phage having a genome containing the nucleotide sequence of SEQ ID NO: 4 or a sequence having at least 90% identity with it, and (v) one or more combinations of these phages;

[0026] b) Select bacteriophages that exhibit lytic activity against the strain.

[0027] c) Optionally, further select active bacteriophages that exhibit synergistic activity against the strain when combined; and / or

[0028] d) Optionally, further select viable phages that do not exhibit antagonistic effects when combined; and / or

[0029] e) Optionally select live phages belonging to different genera; and

[0030] f) Combine the selected phages. Detailed Implementation

[0031] This invention relates to novel bacteriophages, their components, compositions containing said bacteriophages, their manufacture, and their use as antibacterial agents, particularly for treating infections in humans or animals or improving the condition of said objects by modifying the microbial flora in said objects.

[0032] definition

[0033] To facilitate understanding of this invention, many terms are defined below.

[0034] When used herein, the term "phage" refers to a functional phage particle containing a nucleic acid genome packaged in a protein envelope or capsid. The term also refers to portions of a phage that provide substantially the same functional activity, including assemblies of, for example, heads or phage components.

[0035] The term "phenotypic characteristics" more preferably refers to the morphology and / or host range of a bacteriophage. Methods for determining bacteriophage phenotypes are known in the past and include, for example, determining bacterial host range and / or activity against biofilms produced by certain bacterial strains.

[0036] When used in this invention, the term "lytic activity" refers to the ability of a bacteriophage to induce lysis of bacterial cells. The lytic activity of a bacteriophage can be tested on Staphylococcus aureus strains according to techniques known in the art (see also the Experimental Section).

[0037] The term "variant" of a reference phage refers to a phage that has variations in its genomic sequence and / or the polypeptide encoded by it compared to the reference phage. The variant may have different phenotypic characteristics compared to the reference phage, such as a different bacterial host range. In certain cases, variants can be acquired through directed evolution (also known as phage training), a technique that allows the variant to acquire lytic activity against one or more bacterial strains. Variants typically exhibit the same morphology as the reference phage. Typically, the reference phage has a nucleic acid sequence comprising a sequence selected from any of SEQ ID NO: 1-4. Variants typically contain, for example, silent mutations, conserved mutations, small deletions, and / or small duplications in the genetic material. In a preferred embodiment, the variants of the invention retain any observable characteristics or properties dependent on the genome of the phage of the invention, such as the phenotypic characteristics of the phage and / or lytic activity against Staphylococcus aureus strains. Preferred variants have less than 5%, even more preferably less than 4%, and more preferably less than 2%, of nucleic acid variation compared to the genome of the reference phage. Optionally or in combination, the variant preferably has less than 5% amino acid variation in the encoded polypeptide sequence compared to the polypeptide of the reference phage.

[0038] For bacteriophages, the term "specific" or "specific" refers to the types of hosts that the bacteriophage can infect. More preferably, a bacteriophage "specific" to Staphylococcus aureus refers to a bacteriophage that can infect one or more strains of Staphylococcus aureus and, under physiological conditions, is substantially non-Staphylococcal bacteria.

[0039] When used herein, the term “peptide” refers to a polypeptide of any size, including, for example, small peptides of 5 to 20 amino acids, longer polypeptides, proteins, or fragments thereof.

[0040] In the context of this specification, the term "isolated phage" should be understood to mean a phage extracted from its natural environment and / or separated from components of its natural environment and / or produced by directed evolution. This term specifically refers to phages that are cultured, purified, and / or formulated with any suitable formulation product, such as a diluent or excipient, for example. For nucleic acids or polypeptides, the term "isolated" refers to a nucleic acid molecule or polypeptide separated from at least one component of its natural environment, such as a protein, lipid, sugar, and / or nucleic acid.

[0041] When used herein, the term "pharmaceutical or veterinary" means any material (e.g., carrier, excipient, or diluent) compatible with use in human or animal subjects. These materials include physiologically acceptable solutions or media that are harmless to organisms or do not elicit any significant specific or nonspecific immune response or disintegrate the biological activity of the active compound. To formulate the composition into a liquid dosage form, saline, sterile water, Ringer's solution, buffered physiological saline, albumin infusion solution, dextran solution, maltodextrin solution, glycerol, ethanol, and mixtures thereof can be used as pharmaceutical or veterinary excipients or carriers. Other conventional additives such as thickeners, diluents, buffers, preservatives, surfactants, antioxidants, and antibacterial agents may be added if necessary. Furthermore, diluents, dispersants, surfactants, binders, and lubricants may be additionally added to the composition to prepare injectable formulations such as aqueous solutions, suspensions, and emulsions; oral formulations such as pills, capsules, granules, or tablets; powder formulations; and aerosolized formulations such as liquids or powders.

[0042] When used herein, “PFU” refers to plaque-forming unit, as clearly defined in the art. A lysing phage lyses the host cell, creating a clear zone (or plaque) on a culture plate. Theoretically, each plaque is formed by one phage, and the number of plaques multiplied by the dilution factor equals the total number of phages in the test formulation.

[0043] When used herein, “CFU” refers to colony-forming unit, as is clearly defined in the art for estimating the number of viable bacteria in a sample.

[0044] The term "treatment" or "therapy" refers to curative or preventative treatment of a disease. Curative treatment is defined as treatment that leads to the cure of a disease, or treatment that alleviates, reduces, stabilizes, or eliminates the symptoms of a disease or the suffering it causes directly or indirectly, or treatment that improves the condition of a subject or slows the progression of the disease. Preventative treatment includes treatment that leads to the prevention of a disease and / or treatment that reduces and / or delays the incidence of a disease or the risk of its occurrence.

[0045] When used herein, the term "biofilm" refers to heterogeneous bacterial formations grown on various surfaces; preferably, bacterial communities embedded in an extracellular polysaccharide matrix attached to a solid biological or non-biological surface.

[0046] When used herein, the term “damage” refers to any alteration of integrity. Damage to a bacterial biofilm is understood as biofilm denaturation and / or invasion by bacteriophages, infection and / or lysis of biofilm-associated bacteria, and / or partial or complete removal of the biofilm (i.e., by cessation of colonization and / or disruption of the biofilm).

[0047] When used herein, the term "sample" means any sample, such as a biological sample, particularly a sample containing cells. Examples of such samples include bodily fluids such as blood, plasma, saliva, feces, or urine, as well as biopsy, organ, tissue, or cell samples. The samples may be processed.

[0048] When used herein, the term “object” or “patient” refers to an animal, preferably a human, including adults and children. The term “object” also covers animals, such as, but not limited to, pets (e.g., dogs, cats), farm animals such as horses, cows, goats, pigs, sheep, poultry, non-human primates, and fish, shellfish, shrimp, etc.

[0049] When used herein, the term "efficacy" of treatment or "response" to phage therapy refers to a reduction in the number of Staphylococcus aureus strains in a subject after phage therapy compared to the pre-treatment number. A "good responder" subject is one who has shown or will show a clinically significant recovery when treated with phage therapy.

[0050] The term "mixture" of bacteriophages refers to a combination of different bacteriophages. The bacteriophages in a mixture are preferably formulated together in the same container or package, although they can also be used as kits of parts, in which certain bacteriophages are formulated or packaged separately and combined for use or administration.

[0051] When used herein, the term "sequence identity" is determined by comparing two optimally aligned sequences within a comparison window, wherein, for optimal alignment of the two sequences, the polynucleotide fragment in the comparison window may contain additions or deletions (e.g., gaps or protrusions) compared to a reference sequence without additions or deletions. The percentage of sequence identity is calculated as follows: the number of positions in which identical nucleic acid bases or amino acid residues appear in the two sequences is determined to obtain the number of matching positions; the number of matching positions is divided by the total number of positions in the comparison window, and the result is multiplied by 100 to obtain the percentage of sequence identity. The optimal alignment of sequences for comparison can be achieved by Smith and Waterman’s local homology algorithm (Add.APL.Math.2:482(1981)), Needleman and Wunsch’s homology alignment algorithm (J.Mol.Biol.48:443(1970)), Pearson and Lipman’s similarity search method (Proc.Natl.Acad.Sci.(USA)85:2444(1988)), computerized implementations of these algorithms (GAP, BESTFIT, BLAST, PASTA, and TFASTA in the Wisconsin genetics software package, Genetics Computer Group (GCG), 575 Science Dr., Madison, WI) or by visual inspection.

[0052] Description of Implementation

[0053] This invention relates to novel phage therapy for Staphylococcus aureus (S. aureus) infection. More specifically, this invention relates to novel phages with high lytic activity against Staphylococcus aureus (S. aureus) strains, their manufacture, their components, compositions comprising them, and their use in phage therapy.

[0054] bacteriophage

[0055] In a first aspect, the present invention discloses the isolation and characterization of novel bacteriophages that possess lytic activity against Staphylococcus aureus strains and exhibit, individually or in combination, a superior host range of lytic activity. These bacteriophages have been isolated, sequenced, and characterized. They possess activity against Staphylococcus aureus strains, individually and in combination. They are significantly and effectively resistant to pathogenic Staphylococcus aureus strains, including antibiotic-resistant Staphylococcus aureus strains such as methicillin-resistant Staphylococcus aureus (MRSA) strains. These bacteriophages can be combined and formulated into states suitable for use as pharmaceutical or veterinary agents to exhibit very strong antibacterial effects against a controlled range of Staphylococcus aureus strains.

[0056] More specifically, the following bacteriophages have been isolated. Their corresponding nucleic acid sequences have also been annotated.

[0057] Table 1

[0058]

[0059]

[0060] The lysis profiles of these phages have been determined on a wide range of Staphylococcus aureus strains. The results demonstrate broad-spectrum activity (specific and total activity) of the four phages of this invention. These four phages are members of the order Caudovirales.

[0061] Bacteriophage PN1137 is a member of the family Podoviridae and has the nucleotide sequence SEQ ID NO: 1, containing 17,213 nucleotides. It exhibited specific lytic activity against 46 of the 109 tested Staphylococcus aureus strains, representing 42.2% of those strains. Furthermore, phage PN1137 showed total lytic activity against 81 of the 109 tested strains, representing 74.31% of those strains.

[0062] Bacteriophage PN1493 is a member of the Myoviridae family and has the nucleotide sequence SEQ ID NO: 2, containing 134,876 nucleotides. It exhibited specific lytic activity against 86 of the 109 tested Staphylococcus aureus strains, representing 78.9% of those strains. Furthermore, phage PN1493 showed total lytic activity against 108 of the 109 tested strains, representing 99.08% of those strains.

[0063] Bacteriophage PN1815 is a member of the Myoviridae family and has the nucleotide sequence SEQ ID NO: 3, containing 136,156 nucleotides. It exhibited specific lytic activity against 59 of the 109 tested Staphylococcus aureus strains, representing 54.13% of those strains. Furthermore, phage PN1815 showed total lytic activity against 108 of the 109 tested strains, representing 99.08% of those strains.

[0064] Bacteriophage PN1957 is a member of the family Podoviridae and has the nucleotide sequence SEQ ID NO: 4, containing 17,629 nucleotides. It exhibited specific lytic activity against 71 of the 109 tested Staphylococcus aureus strains, representing 65.14% of those strains. Furthermore, phage PN1957 showed total lytic activity against 95 of the 109 tested strains, representing 87.16% of those strains.

[0065] These combinations of bacteriophages exhibit specific lytic activity covering at least 74 of the said strains (67%). Specifically, bacteriophages PN1493 and PN1957 together exhibit specific lytic activity covering 98 of the said Staphylococcus aureus strains (89.9%) and total lytic activity covering 100% of the said Staphylococcus aureus strains.

[0066] Therefore, a specific object of the present invention is a bacteriophage that has lytic activity against Staphylococcus aureus strains and has a genome comprising a nucleotide sequence selected from any one of SEQ ID NO: 1 to 4 or a sequence having at least 95% identity with it, preferably at least 96%, 97%, 98% or 99% identity with it.

[0067] The phages of the present invention can be prepared using standard culturing, isolation, and purification methods. For example, *Staphylococcus aureus* producing bacteria are cultured, infected with a phage sample, and then treated to remove bacterial cells and debris. The enriched phage solution can be plated in a medium, such as agar, containing an embedded susceptible *Staphylococcus aureus* host strain to obtain plaques. Individual plaques can then be picked for subsequent phage purification and amplification. One or more selective amplification cycles of the phages of the present invention can be performed, for example, by mixing the phage with competent *Staphylococcus aureus*, adding growth medium, and incubating under selected experimental growth conditions. After centrifugation, the clarified amplification supernatant is filtered and another selective amplification cycle is performed or the presence of lytic activity is tested.

[0068] Subsequently, the titer of the phage in the suspension and the visualization of the plaque morphology of the phage of the present invention can be assessed by known methods, such as by plaque counting. Furthermore, as is known in the art, the phage of the present invention can be processed into various different forms (liquid, lyophilized, etc.) by any suitable method for short-term, long-term, frozen, or any other type of storage (see, for example, Clark, 1962).

[0069] The lytic activity of the bacteriophages of the present invention can be evaluated using methods known in the art, such as plaque assays (also known as double agar assays), on the basis of growing the bacteriophages with potential host bacteria and then assessing their ability to kill the host bacterial cells. In the plaque assay, after incubation in soft agar medium for a period of time, the bacteriophages induce lysis of the target Staphylococcus aureus strain, producing a clear zone on the plate called a plaque.

[0070] As will be disclosed in more detail below, the phages of the present invention can be cultured, amplified, isolated, purified, and used in phage therapy for diseases mediated by, for example, Staphylococcus aureus. Furthermore, variants of these phages that retain phenotypic characteristics (e.g., lytic activity) can be produced and / or isolated using techniques known per se in the art.

[0071] Nucleic acids and polypeptides

[0072] This invention relates to nucleic acids or any fragments of such nucleic acids contained in the bacteriophages of this invention. The term "fragment" more preferably refers to a fragment containing (or constituting) an open reading frame. The nucleic acid may be DNA or RNA, and may be single-stranded or double-stranded.

[0073] The nucleic acid may be isolated from preserved bacteriophages or produced using recombinant DNA technologies (e.g., polymerase chain reaction (PCR) amplification, cloning), enzymatic synthesis, or chemical synthesis, or a combination thereof, according to techniques generally known in the art. It also includes its homologous sequences and fragments, including but not limited to natural allelic variants and nucleic acid sequences in which nucleotides have been inserted, deleted, substituted, and / or inverted.

[0074] In a particular embodiment, the present invention relates to nucleic acids comprising a sequence selected from any of SEQ ID NO: 1-4 or a sequence having at least 95%, 96%, 97%, 98%, 99% or higher sequence identity with any of SEQ ID NO: 1-4.

[0075] The nucleic acids of the present invention can be in free form or cloned in a vector such as a plasmid, viral vector, expression cassette, or granules.

[0076] On the other hand, the present invention also relates to isolated polypeptides encoded by nucleic acid sequences as defined above, preferably by nucleic acid sequences selected from SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, or SEQ ID NO: 4. The polypeptides can be produced by techniques known per se in the art, such as synthesis, recombinant techniques, or combinations thereof. The polypeptides can be isolated or purified and used as antibacterial agents or as reagents for in vitro analysis.

[0077] The composition of the present invention

[0078] One aspect of the invention relates to compositions comprising at least one, more preferably at least two or more phages as described above, and optionally pharmaceutically or veterinarily applicable excipients. As described, the phages of the present invention exhibit very strong lytic activity against Staphylococcus aureus strains. Combinations of these phages can be generated to expand the host range and produce highly effective antibacterial compositions.

[0079] More specifically, the present invention relates to an antibacterial composition comprising at least one bacteriophage having lytic activity against Staphylococcus aureus strains, said at least one bacteriophage being selected from bacteriophages having a genome having a nucleotide sequence comprising any one of SEQ ID NO: 1 to 4 or having at least 90% identity with such sequences, for example having at least 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity with such sequences.

[0080] On the one hand, compared to a reference phage having a sequence of any one of SEQ ID NO: 1-4, a phage having a genome containing a nucleotide sequence having at least 90% identity with any one of SEQ ID NO: 1-4, for example, having at least 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity with any one of SEQ ID NO: 1 to 4, can have the same phenotypic characteristics. Typically, the phages have the same bacterial host range. Such phages typically contain, for example, silent mutations, conserved mutations, few deletions, and / or few copies of genetic material.

[0081] On the other hand, phages having genomes containing nucleotide sequences with at least 90% identity to any of SEQ ID NO: 1 to 4, such as at least 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity to any of SEQ ID NO: 1-4, may be produced by directed evolution (phage training) and may have different bacterial host ranges. Typically, such phages are active against a wider range of bacterial strains compared to reference phages having sequences from any of SEQ ID NO: 1-4.

[0082] More specifically, the present invention relates to an antibacterial composition comprising at least two bacteriophages having lytic activity against Staphylococcus aureus strains, said at least two bacteriophages being selected from bacteriophages having a genome having a nucleotide sequence comprising any one of SEQ ID NO: 1 to 4 or having at least 90% identity with such sequences, for example, having a sequence having at least 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity with such sequences.

[0083] In another specific embodiment, the composition of the present invention comprises at least three, or more preferably at least four, different phages selected from phages having a genome having a nucleotide sequence comprising any one of SEQ ID NO: 1 to 4 or having at least 90% identity with such sequences, for example, sequences having at least 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identity with such sequences.

[0084] Specific examples of the compositions of the present invention include:

[0085] - Phages having a genome containing the nucleotide sequence of SEQ ID NO: 1 or a sequence having at least 90% identity with it, and phages having a genome containing the nucleotide sequence of SEQ ID NO: 2 or a sequence having at least 90% identity with it;

[0086] - Phages having a genome containing the nucleotide sequence of SEQ ID NO: 1 or a sequence having at least 90% identity with it, and phages having a genome containing the nucleotide sequence of SEQ ID NO: 3 or a sequence having at least 90% identity with it;

[0087] - Phages having a genome containing the nucleotide sequence of SEQ ID NO: 1 or a sequence having at least 90% identity with it, and phages having a genome containing the nucleotide sequence of SEQ ID NO: 4 or a sequence having at least 90% identity with it;

[0088] - Phages having a genome containing the nucleotide sequence of SEQ ID NO: 2 or a sequence having at least 90% identity with it, and phages having a genome containing the nucleotide sequence of SEQ ID NO: 3 or a sequence having at least 90% identity with it;

[0089] - Phages having a genome containing the nucleotide sequence of SEQ ID NO: 2 or a sequence having at least 90% identity with it, and phages having a genome containing the nucleotide sequence of SEQ ID NO: 4 or a sequence having at least 90% identity with it;

[0090] - Phages having a genome containing the nucleotide sequence of SEQ ID NO: 3 or a sequence having at least 90% identity with it, and phages having a genome containing the nucleotide sequence of SEQ ID NO: 4 or a sequence having at least 90% identity with it;

[0091] - Phages having a genome containing the nucleotide sequence of SEQ ID NO: 1 or a sequence having at least 90% identity with it; phages having a genome containing the nucleotide sequence of SEQ ID NO: 2 or a sequence having at least 90% identity with it; and phages having a genome containing the nucleotide sequence of SEQ ID NO: 3 or a sequence having at least 90% identity with it.

[0092] - Phages having a genome containing the nucleotide sequence of SEQ ID NO: 1 or a sequence having at least 90% identity with it; phages having a genome containing the nucleotide sequence of SEQ ID NO: 2 or a sequence having at least 90% identity with it; and phages having a genome containing the nucleotide sequence of SEQ ID NO: 4 or a sequence having at least 90% identity with it.

[0093] - Phages having a genome containing the nucleotide sequence of SEQ ID NO: 1 or a sequence having at least 90% identity with it; phages having a genome containing the nucleotide sequence of SEQ ID NO: 3 or a sequence having at least 90% identity with it; and phages having a genome containing the nucleotide sequence of SEQ ID NO: 4 or a sequence having at least 90% identity with it; or

[0094] - Phages having a genome containing the nucleotide sequence of SEQ ID NO: 2 or a sequence having at least 90% identity with it, phages having a genome containing the nucleotide sequence of SEQ ID NO: 3 or a sequence having at least 90% identity with it, and phages having a genome containing the nucleotide sequence of SEQ ID NO: 4 or a sequence having at least 90% identity with it.

[0095] In certain embodiments, the compositions of the present invention comprise at least:

[0096] - A bacteriophage having a genome containing the nucleotide sequence of SEQ ID NO: 1 or a sequence having at least 90% identity with it;

[0097] - A bacteriophage having a genome containing the nucleotide sequence of SEQ ID NO: 2 or a sequence having at least 90% identity with it;

[0098] - A bacteriophage having a genome containing the nucleotide sequence of SEQ ID NO: 3 or a sequence having at least 90% identity with it; and

[0099] - A bacteriophage having a genome containing the nucleotide sequence of SEQ ID NO: 4 or a sequence having at least 90% identity with it.

[0100] The compositions of the present invention may comprise phage mixtures as shown in Table 2:

[0101] Table 2 The bacteriophage mixture of the present invention

[0102] mixture bacteriophage 1 PN1137+PN1493 2 PN1137+PN1815 3 PN1137+PN1957 4 PN1493+PN1815 5 PN1493+PN1957 6 PN1815+PN1957 7 PN1137+PN1493+PN1815 8 PN1137+PN1493+PN1957 9 PN1137+PN1815+PN1957 10 PN1493+PN1815+PN1957 11 PN1137+PN1493+PN1815+PN1957

[0103] The compositions of the present invention may also contain other antibacterial agents, particularly other bacteriophages with different host specificities.

[0104] The most preferred composition of the present invention exhibits lytic activity against more than 70% of the 109 bacterial strains identified by the Centre National de Référence des Staphylocoques de Lyon. This collection contains a large number of diverse Staphylococcus aureus strains that have the highest incidence rates in Europe and the United States.

[0105] The compositions of the present invention may contain any effective amount of the selected phage. Preferably, they contain 10 e1 Up to 10 e12 Between PFU / ml, preferably 10 e4 Up to 10 e11 Each of the aforementioned phages is between PFU / ml. The relative amount of each type of phage in the compositions of the present invention can be adjusted by a person skilled in the art. Generally, when the antibacterial composition contains several (n) different phages as defined above, the total relative amount %A of each phage in the composition is more preferably %A = (100 / n) i )xV, where n i V represents the number of different bacteriophages, and is a coefficient of variation between 0.2 and 5. Most preferably, V is between 0.3 and 3, even more preferably between 0.5 and 2, and generally between 0.8 and 1.5. In a preferred typical embodiment, each type of bacteriophage is present in approximately equal relative amounts in the composition of the invention.

[0106] The antibacterial compositions of the present invention can be in various forms, such as liquid, semi-liquid, solid, or lyophilized formulations. The compositions of the present invention preferably contain a suitable diluent or carrier, such as a pharmaceutically or veterinarily applicable excipient or carrier. In addition to the selected bacteriophage, the compositions of the present invention may also include any excipient or carrier, such as thickeners, diluents, buffers, preservatives, surfactants, etc. These include physiologically acceptable solutions or media that are harmless to the organism or do not elicit any significant specific or nonspecific immune response or negate the biological activity of the bacteriophage. For liquid formulations, saline, sterile water, Ringer's solution, buffered physiological saline, albumin infusion, dextran solution, maltodextrin solution, glycerol, ethanol, and mixtures thereof can be used as pharmaceutically or veterinarily applicable excipients or carriers. Other conventional additives, such as thickeners, diluents, buffers, preservatives, surfactants, antioxidants, and antibacterial agents, may be added if appropriate. In addition, diluents, dispersants, surfactants, binders, and lubricants may be added to the composition to prepare injectable formulations such as aqueous solutions, suspensions, and emulsions; oral formulations such as pills, capsules, granules, or tablets; powder formulations having dried and / or extruded powders; and aerosolized formulations having liquid or dry aerosols. Formulations for surface administration may include bandages, dressings, patches, films, ointments, lotions, creams, gels, drops, suppositories, sprays, tampons, sanitary napkins, liquids, and powders. Formulations for disinfection or for medical use may also include aerosols or sprays.

[0107] The compositions of the present invention can be used in the medical field, including human or veterinary medicine, for example, to treat infections or improve the condition of a subject. The compositions can be used to reduce or kill Staphylococcus aureus bacteria in an organism for the treatment of infections. The compositions can also be used to improve the condition of a subject by modifying its microbial flora. Specifically, the compositions of the present invention can specifically remove Staphylococcus aureus strains from the skin or mucous membranes of a subject, thereby modifying its microbial flora and restoring a suitable balance.

[0108] In certain embodiments, the present invention also relates to a method for treating an infection in a subject, the method comprising administering to the subject a composition, bacteriophage, nucleic acid, or polypeptide as defined above.

[0109] The present invention also relates to the use of the described phage compositions, nucleic acids or peptides in the manufacture of medicaments for treating infections in subjects or restoring the microbial community in said subjects.

[0110] The compositions of the present invention can be used to treat a variety of Staphylococcus aureus-mediated infections, particularly diabetic or non-diabetic foot ulcer infections, or bone infections such as, but not limited to, osteomyelitis or septic arthritis or joint infections or prosthetic joint infections, or skin infections such as, but not limited to, atopic dermatitis, acne, impetigo, staphylococcal scalded skin syndrome, or soft tissue infections, or pleural and pulmonary infections, or other clinical syndromes such as, but not limited to, meningitis or urinary tract infections or sepsis or endocarditis or otitis.

[0111] The compositions of the present invention can be administered via any convenient route, including intravenous, oral, transdermal, subcutaneous, mucosal, intramuscular, intrapulmonary, intranasal, parenteral, rectal, vaginal, and topical administration. The phages or compositions can also be administered via intrapulmonary or intranasal instillation or nebulization. The compositions can be administered directly or indirectly, for example via a support or device (e.g., a nebulizer, bandage, etc.). In this regard, the compositions can be applied or sprayed onto the affected area, for example. The compositions of the present invention can also be administered orally or parenterally. The appropriate dosage for application, spraying, or administration of the compositions of the present invention can be adjusted by those skilled in the art based on various factors, including the formulation, route of administration, the age, weight, sex, condition, diet, route of administration, and responsiveness of the treated subject at the time of administration. Physicians or veterinarians with ordinary skills in the art can readily determine and prescribe the desired effective amount of the composition.

[0112] Dosage can also be adjusted by a qualified technician to achieve lytic activity against antibiotic-resistant Staphylococcus aureus strains. Depending on the route of administration, the effective dose for achieving lytic activity in vivo typically includes at least 10... e4 PFU / ml, preferably about 10 e2 Up to 10 e12 PFU / ml concentration.

[0113] In certain embodiments, the phages, compositions, and mixtures of the present invention are used to treat diabetic and non-diabetic foot ulcer infections, bone and joint infections, prosthetic joint infections, or respiratory infections.

[0114] In cases such as diabetic foot ulcers infected with methicillin-resistant or methicillin-sensitive Staphylococcus aureus (MRSA or MSSA), patients may receive 10... 4 Up to 10 10A dressing impregnated with a phage solution of PFU / ml is applied daily to every ten days, for example, every two to nine days, preferably every three to eight days, more preferably every seven days, with or without antibiotics, until the wound closes. The efficacy of the treatment can be measured by a relative reduction in bacterial load.

[0115] In cases of recurrent Staphylococcus aureus (S. aureus) (MRSA or MSSA) prosthetic joint infection, such as in the hip or knee, patients can receive phage therapy in conjunction with standard surgery, with or without antibiotics. A concentration of 10% can be added at the end of the explantation. 4 Up to 10 10 A PFU / ml phage solution is dispersed in the surgical field within the bone, joint space, and / or muscle tissue. A second dispersal of the same formulation can be performed immediately after reimplantation and before the surgical site closes. Additional application may be given while the wound is still open, such as during wound dressing. 10 4 Up to 10 10 Supplemental oral phage administration of PFU / ml to support local treatment.

[0116] In cases of bone reshaping surgery involving Staphylococcus aureus (MRSA or MSSA) infection, an absorbable plaster containing 10g of [unspecified substance] can be placed at the base of the surgical site after bone curettage. 4 Up to 10 10 A pressure pad containing PFU / ml phage is applied to the infected scraped bone. The remainder of the cavity can be filled with other sterile pressure pads, and the surgical site is covered with a waterproof dressing. Alternatively, a vacuum-assisted closure (VAC) system can be used, following drainage to remove blood or serous fluid from the wound or surgical site, followed by phage infusion with or without antibiotics (10). 4 Up to 10 10 The phage is circulated at a rate of PFU / ml. It remains in place for several hours before drainage is restarted. This circulation can be repeated several times over several days post-surgery.

[0117] In cases of respiratory infection, 10 can be administered using a nebulizer. 4 Up to 10 10 A phage solution of PFU / ml. Nebulization can be performed using a portable inhaler or an additional nebulizer connected to a medical mechanical ventilator. Phage solution volumes, for example, ranging from 1 to 20 ml, can be nebulized at various time intervals and during treatment. Lung lavage can be performed using the same phage solution before initiating the first nebulization, depending on the patient's condition.

[0118] As shown in the experimental section, the bacteriophages and compositions of the present invention are capable of effectively killing a broad range of Staphylococcus aureus bacteria. The compositions can even destroy mixtures of different Staphylococcus aureus bacteria at low doses. Furthermore, the compositions of the present invention strictly do not affect eukaryotic cells, are therefore specific, and have no side effects when administered to humans and animals.

[0119] This invention also relates to the use of the compositions, bacteriophages, nucleic acids, or peptides of this invention in the disinfection of materials. Due to their potent antibacterial effects and their ability to even disrupt the integrity of bacterial biofilms, the compositions of this invention can be used as disinfectants to eliminate bacteria on materials or at least reduce their number. Such methods can be applied to the treatment of a wide variety of biological or non-biological surfaces in both medical and non-medical contexts, including solid materials or devices such as contact lenses, surfaces of devices to be implanted in the body, pipes, catheters, laboratory containers, fabrics, clothing, footwear, housing, military equipment, etc.

[0120] The present invention also relates to a method for preparing the composition of the present invention, wherein the composition comprises at least two bacteriophages, the method comprising producing the at least two bacteriophages separately and combining the bacteriophages with a suitable carrier or excipient.

[0121] The compositions of the present invention can be used in combination with at least one antibiotic. This co-administration allows for a reduction in the amount of antibiotic used, restoration of antibiotic efficacy, or sensitization of bacteria embedded in biofilms to antibiotics.

[0122] The diagnostic / predictive test of this invention - companion diagnostics:

[0123] The present invention also relates to a method for predicting or determining the efficacy of phage therapy in a subject, wherein the method includes the step of determining the lytic activity of one or more phages of the present invention against a sample of *Staphylococcus aureus* strains from the subject, such lytic activity indicating highly effective treatment. Preferably, the method optionally further includes the step of treating the subject with one or more phages having lytic activity against a sample of *Staphylococcus aureus* strains from the subject.

[0124] On the other hand, the present invention provides a method for selecting a subject or determining whether a subject is likely to benefit from phage therapy, wherein the method includes the step of determining the lytic activity of one or more phages of the present invention against a Staphylococcus aureus strain from a sample of the subject, wherein the lytic activity of one or more phages of the present invention against at least one Staphylococcus aureus strain indicates the responder subject.

[0125] Another object of the present invention relates to a method for predicting a subject's response to a phage therapy, wherein the method includes the step of determining the lytic activity of one or more phages of the present invention against a Staphylococcus aureus strain from a sample of the subject, the lytic activity of one or more phages of the present invention against at least one Staphylococcus aureus strain indicating a good response to the therapy.

[0126] On the other hand, the present invention provides a method for evaluating the susceptibility of Staphylococcus aureus strains to bacteriophages, wherein the bacteriophages are selected from bacteriophages having a genome containing a nucleotide sequence comprising any one of SEQ ID NO: 1 to 4 or a sequence having at least 90% identity with it, and / or at least one mixture of bacteriophages listed in Table 2, the method comprising:

[0127] a) Contacting the *Staphylococcus aureus* strain with at least one bacteriophage and / or a mixture of at least one bacteriophage, and

[0128] b) Determine the lytic activity of the phage and / or mixture against the strain, thereby assessing the susceptibility of the strain to the phage and / or mixture.

[0129] Step a) can be performed in vitro by contacting, exposing, or mixing a strain of Staphylococcus aureus with at least one bacteriophage and / or a mixture of at least one bacteriophage in any medium suitable for this step (e.g., solid or liquid).

[0130] In a preferred embodiment, determining the lytic activity of the phage and / or mixture includes measuring the amplification of the phage in the *Staphylococcus aureus* strain, wherein an increase in the phage concentration indicates the lytic activity of the phage and / or mixture against the strain.

[0131] Phage concentration can be measured using any technique known to those skilled in the art, such as plaque formation, polymorphic chain reaction (PCR), bioluminescence, etc.

[0132] Alternatively or additionally, the determination of the lytic activity of the phage and / or mixture includes determining the plaque shadow in a plaque assay.

[0133] However, when complete or partial lysis of the bacterial pad is observed in the presence of a bacteriophage in a solid culture medium of bacteria, the bacterial strain may also be considered sensitive to the bacteriophage.

[0134] Other techniques known to those skilled in the art can be used to evaluate the lytic activity of the phage and / or mixture.

[0135] Another object of the present invention relates to a method for determining a mixture of bacteriophages effective against a target strain of Staphylococcus aureus, the method comprising:

[0136] a) Contact the target Staphylococcus aureus strain or a sample containing the strain separately with the following phages: (i) a phage having a genome containing the nucleotide sequence of SEQ ID NO: 1 or a sequence having at least 90% identity with it, and / or (ii) a phage having a genome containing the nucleotide sequence of SEQ ID NO: 2 or a sequence having at least 90% identity with it, and / or (iii) a phage having a genome containing the nucleotide sequence of SEQ ID NO: 3 or a sequence having at least 90% identity with it, and / or (iv) a phage having a genome containing the nucleotide sequence of SEQ ID NO: 4 or a sequence having at least 90% identity with it, and / or (v) one or more combinations of these phages;

[0137] b) Select bacteriophages that exhibit lytic activity against the strain.

[0138] c) Optionally, further select active bacteriophages that exhibit synergistic activity against the strain when combined; and / or

[0139] d) Optionally, further select viable phages that do not exhibit antagonistic effects when combined; and / or

[0140] e) Optionally select live phages belonging to different genera; and

[0141] f) Combine the selected phages.

[0142] This method can be used as a phage assay to determine which mixture has the best lytic activity against a specific strain of Staphylococcus aureus.

[0143] Other aspects and advantages of the invention will be disclosed in the experimental section below, which is merely illustrative.

[0144] Example

[0145] method

[0146] Classification and identification of bacteriophages

[0147] The four bacteriophages of this invention (PN1137, PN1493, PN1815, and PN1957) were studied using electron microscopy. The results showed that these bacteriophages belong to the order Caudovirales and the families Podovirae and Myoviridae, as described below:

[0148] -PN1137: Podocirae (short-tailed bacteriophages)

[0149] -PN1483: Myoviridae (myovirophage family)

[0150] -PN1815: Myoviridae (family Myoviridae)

[0151] -PN1957: Podocirae (short-tailed bacteriophage family).

[0152] Sequencing and analysis of bacteriophage genomes

[0153] Phage DNA was isolated by extraction with phenol:chloroform:isoamyl alcohol (25:24:1, V / V), ethanol precipitation, and redissolution in water. Whole-genome sequencing was performed, and the BLAST algorithm was used to determine similarity to genes described in the National Center for Biotechnology Information (NCBI) database. The genome was scanned to obtain potential open reading frames (ORFs). The nucleic acid sequences are shown as SEQ ID NO: 1-4. Sequence alignment using the database yielded the same classification identification as using electron microscopy.

[0154] Example 1: In vitro characterization: host range

[0155] There are likely two different types of bacterial lysis: lysis caused by the enzymatic hydrolysis of the bacterial cell wall by the phage (referred to as "non-specific" lysis) and lysis caused by phage amplification (referred to as "specific" lysis). Both types of lysis are related to the utility of the phage. For each phage, both specific and non-specific lysis were identified using two methods.

[0156] Phage amplification in solid culture medium

[0157] This method allows for the assessment of the ability of bacteriophages to amplify and lyse bacteria.

[0158] The method involves depositing multiple dilutions (at a ratio of 10) of a phage suspension onto the surface of an agar containing bacteria. The agar is then incubated at 37°C for 18 hours to allow the bacterial pads to develop. The deposited areas are then analyzed. The following may occur:

[0159] -Scenario 1: No lysis of the bacterial pad is found in the deposition area.

[0160] -Scenario 2: The bacterial pad completely lyses at the deposition area.

[0161] -Scenario 3: The bacterial pad partially ruptures at the deposition area, and

[0162] -Scenario 4: Plaques (plaque-forming units (PFUs)) were observed in the deposition area.

[0163] Only the formation of plaques (case 4) can confirm the ability of bacteriophages to amplify and effectively lyse the bacteria in the bacterial strain.

[0164] If cases 1, 2, and / or 3 are observed but case 4 is not present, then the strain is tested in liquid culture medium.

[0165] Phage amplification in liquid culture medium

[0166] This method allows for the assessment of bacteria's ability to produce bacteriophages.

[0167] The method involves culturing the bacterial strain and bacteriophage at 37°C for 18 hours. The concentration of bacteriophage in the supernatant is then determined. If the concentration of bacteriophage after culturing is higher than the initial concentration, this indicates that the bacteriophage has been amplified by the bacteria.

[0168] The ability of bacteria to produce bacteriophages depends in particular on the multiple of infection (MOI), i.e., the phage / bacteria ratio. Several MOIs were tested.

[0169] The phage titer after culture was determined using a method similar to that used in spot tests. Multiple dilutions of the culture supernatant (at a ratio of 10) were deposited on both an agar surface containing the production strain of the phage and an agar surface containing the patient strain. The agar was then incubated at 37°C for 18 hours. The number of plaques on the deposited areas, correlated with the dilution factor, allowed for the determination of the phage concentration.

[0170] Specific activity

[0171] The specificity profile, i.e., the ability of each phage to amplify a group of bacterial strains, was evaluated. A phage was considered to have been amplified by a bacterial strain when the following conditions were met:

[0172] - Case 4 was observed in the solid culture medium test, and

[0173] - In liquid culture medium experiments, the concentration of phages after culture increased 50-fold relative to the initial concentration.

[0174] The group of Staphylococcus aureus strains was identified by the Centre National de Référence des Staphylocoques de Lyon. It includes 109 Staphylococcus aureus strains with the highest incidence rates in Europe and the United States.

[0175] In Table 3 below, "+" indicates that the bacteriophage of the present invention can be amplified by bacterial strains, and "-" indicates that the bacteriophage cannot be amplified by bacterial strains.

[0176] Table 3 Specific activity spectra of PN1137, PN1493, PN1815 and PN1957 against a group of 109 Staphylococcus aureus strains

[0177]

[0178]

[0179]

[0180]

[0181]

[0182] PN1493 and PN1957 showed specific activity against 86 and 71 of the 109 Staphylococcus aureus strains, respectively, accounting for 78.9% and 65.14%.

[0183] PN1137 and PN1815 also exhibited broad-spectrum specific activity. They showed specific activity against 46 and 59 of the described strains, respectively, representing 42.2% and 54.13%.

[0184] Total pyrolysis activity

[0185] The overall lytic activity profile, i.e., the ability of each phage to lyse the strain with or without phage production, has been evaluated. The phage is considered active against the *Staphylococcus aureus* strain under the following conditions:

[0186] - Situations 2, 3, or 4 were observed in the solid culture medium test, or

[0187] - In liquid culture medium experiments, the concentration of phages after culture increased by 50 times compared to the initial concentration.

[0188] In Table 5 below, "+" indicates positive lytic activity of the bacteriophage against the bacterial strain, and "-" indicates no lytic activity of the bacteriophage against the bacterial strain.

[0189] Table 5 Total activity spectrum of PN1137, PN1493, PN1815 and PN1957 against a group of 109 Staphylococcus aureus strains

[0190]

[0191]

[0192]

[0193]

[0194]

[0195] These results demonstrate a very broad activity spectrum of the four phages tested, all exhibiting lytic activity against more than 70% of the 109 *Staphylococcus aureus* strains. Specifically, phages PN1493 and PN1815 showed very good results, exhibiting activity against 108 of the 109 *Staphylococcus aureus* strains, representing over 99% of the strains in the group. PN1137 and PN1957 also showed broad-ranging lytic activity, being effective against 81 and 95 strains from the group, respectively (74.31% and 87.16%, respectively). Every *Staphylococcus aureus* strain from the group was lysed by at least one of the phages. Furthermore, 79 of the strains were lysed by all four phages.

[0196] Example II: Production of the mixture

[0197] Mixture 5: PN1493 and PN1957

[0198] These two bacteriophages have complementary lytic activity ranges. In fact, together they exhibited specific activity against 98 of the tested Staphylococcus aureus strains, representing 89.9% of those strains. Furthermore, their total lytic activity covered all tested Staphylococcus aureus strains. A preferred mixture contains the two bacteriophages in a 1:1 ratio.

[0199] Mixture 6: PN1815 and PN1957

[0200] Similar to Mixture 5, these two phages have complementary lytic activity ranges. Together, they exhibited specific activity (79.8%) against 87 of the tested Staphylococcus aureus strains. Furthermore, their overall lytic activity covered all tested Staphylococcus aureus strains. A preferred mixture contains these two phages in a 1:1 ratio.

[0201] Mixture 1 (PN1137 and PN1493) and Mixture 4 (PN1493 and PN1815)

[0202] Both mixtures also exhibited broad-ranging lytic activity against the tested bacterial strains. Mixtures 1 and 4 showed specific lytic activity against 89 and 87 of the tested strains, respectively (81.6% and 79.8%, respectively). Furthermore, both showed total lytic activity against 108 of the tested strains, representing lytic activity against over 99% of the tested Staphylococcus aureus strains. A preferred mixture contains the two bacteriophages in a 1:1 ratio.

[0203] Mixtures 3, 5, 6, 8, 9, 10, and 11

[0204] These mixtures exhibited total lytic activity against 100% of the strains.

[0205] Example II: In vivo efficacy

[0206] Two mouse models were used to evaluate the efficacy of the phage mixture of the present invention.

[0207] The first model reproduces Staphylococcus aureus infection in diabetic or non-diabetic foot ulcers. It is based on Staphylococcus aureus infection of the hind paw in naive or diabetic mice.

[0208] The second model reproduced Staphylococcus aureus (S. aureus) bone and joint infection (BJI) and prosthetic joint infection (PJI).

[0209] Diabetic foot ulcer model (DFU)

[0210] Diabetes was induced in the mice using streptozotocin. The diabetic state in the mice was based on a blood glucose level of approximately 5 g / L 7 days after induction and an assay for the inactivation of damaged Staphylococcus aureus (S. aureus) in the blood.

[0211] Staphylococcus aureus strains

[0212] Clinical strains isolated from pseudoinfection were selected based on their in situ survival and reproductive capacity. The optimal inoculum was selected based on the persistent bacterial load 14 days post-infection (pi) in diabetic mice with the highest survival rate.

[0213] Experimental Design

[0214] Diabetes was induced by two streptozotocin injections 48 hours apart. One hind paw was infected 14 days after the first streptozotocin injection. Four groups were compared:

[0215] • Phage mixture treatment group. The mixture was administered topically (SC injection) at a multiple of infection (MOI) of 1 30 min post-infection.

[0216] • Phage mixture treatment group. The mixture was administered topically at MOI 10 (SC injection) 30 min after infection.

[0217] • Antibiotic treatment group. Linezolid was administered systemically at 25 mg / kg (IP injection) 30 minutes after infection.

[0218] • Untreated group. PBS was administered topically (SC injection) 30 minutes after infection.

[0219] The study involved 30 mice in each group.

[0220] Mice were euthanized at six time points post-infection, and the number of colony-forming units (CFU) and plaque-forming units (PFU) in the soft tissue and bone of the infected hind paw was counted. Macroscopic observation of edema and lesions was scored according to the method described by Chhibber et al. Myeloperoxidase (MPO) levels were determined to track the inflammatory response, and histological analysis of the hind paw was performed on day 5 to assess differences in inflammatory response among the four groups.

[0221] This model allows for the evaluation of the efficacy of the bacteriophages or bacteriophage mixtures of the present invention against Staphylococcus aureus infection in diabetic foot ulcers.

[0222] Nondiabetic foot ulcer model

[0223] Staphylococcus aureus strains

[0224] The strains used in the diabetic foot ulcer model were also used in the non-diabetic foot ulcer model. The same inoculum was used.

[0225] Experimental Design

[0226] Infecting one hind paw in natural mice. Groups compared in a diabetic foot ulcer model were also studied in a non-diabetic foot ulcer model. The same criteria were used.

[0227] This model allows for the evaluation of the efficacy of the bacteriophages or bacteriophage mixtures of the present invention against Staphylococcus aureus infection in non-diabetic foot ulcers.

[0228] Bone and joint infection models

[0229] Staphylococcus aureus strains

[0230] Clinical strains isolated from protozoan infections were selected based on their in situ survival and reproductive capacity. The optimal inoculum was chosen based on the persistent bacterial load at 7 days post-infection, which yielded the highest survival rate.

[0231] Experimental Design

[0232] In natural mice, infection occurs via the knee. Seven groups were compared:

[0233] • Phage mixture treatment group. The mixture was administered systemically at a high dose 30 minutes after infection.

[0234] • Phage mixture treatment group. The mixture was administered systemically at a low dose 30 minutes after infection.

[0235] • Phage mixture treatment group. The mixture was administered topically at a high dose 30 minutes after infection.

[0236] • Phage mixture treatment group. The mixture was administered topically at a low dose 30 minutes after infection.

[0237] • Antibiotic treatment group.

[0238] • Antibiotic + bacteriophage treatment group.

[0239] • Untreated group.

[0240] The study involved 30 mice in each group.

[0241] The infection process was tracked along with bacterial and phage loads, and the clinical status of mice, such as body weight, food and water consumption.

[0242] This model allows for the evaluation of the efficacy of the bacteriophages or bacteriophage mixtures of the present invention against Staphylococcus aureus (S. aureus) bone and joint infections.

[0243] Prosthetic joint infection model

[0244] Staphylococcus aureus strains

[0245] The strain and inoculum are the same as those in the BJI model.

[0246] Experimental Design

[0247] Kirschner wires were inserted into the femoral cavity of native mice. The mice were then infected via the knee adjacent to the Kirschner wire. Group comparisons and readout data were similar to those of bone and joint infection models.

[0248] This model allows for the evaluation of the efficacy of the bacteriophages or bacteriophage mixtures of the present invention against Staphylococcus aureus (S. aureus) prosthetic joint infections.

[0249] References

[0250] Capparelli R et al., Antimicrob Agents Chemother., Experimental Phage Therapy against Staphylococcus aureus in Mice, 2007 Aug; 51(8):2765–2773.

[0251] Clark WA, 1962, Appl Microbiol., Comparison of several methods for preserving bacteriophages, 1962 Sep; 10:466-71.

[0252] Drulis-Kawa Z, Majkowska-Skrobek G, Maciejewska B, Delattre AS, Lavigne R, 2012, Learning from bacteriophages—advantages and limitations of phage and phage-encoded protein applications, 13(8):699-722.

[0253] Weinbauer MG., Ecology of prokaryotic viruses, FEMS Microbiol Rev 2004; 28:127-81. sequence list <110> Pherecydes Pharma <120> Phage therapy <130> SPI215077-11 <160> 4 <170> PatentIn version 3.5 <210> 1 <211> 17213 <212> DNA <213> Artificial sequence <220> <223> PN1137 <400> 1 aacttctatt ccaacttatc taacctatta catattaatc aaatacattt attatacatc 60 tattgacttt tatcaaaatt tatgattgga acataaaatc taatttcttc tattaaatag 120 tagttttaaa ttatttaaac ttttttaaga aaaactgttg acaaaacttt taaacgtttg 180 ctatactaat tatgtaatca aaacaaggag gtaacaaaaa tggttaatgt tgataatgca 240 ccagaagaaa aaggacaagc ctatactgaa atgttgcaac tattcaataa actgattcaa 300 tggaatccag cttatacatt tgacaatgca attaacttag tagcagcttg ccaacaacta 360 ttattaaact ataacagttc tgttgttcaa ttcttaaaag atgaactaaa caatgaaatt 420 aaaccagaat caatattatc ttacattgct ggtgatgacc ctatagaaca atggaacatg 480 cacaaaggat tttatgaaac gtataacatt tacgtttttt agaaaggaat gatataataa 540 tgaaagctga tgacattgtt gttttacgtg ttaaaggtta tatacttcat tacttagatg 600 atgataatga atacattgag gaatttgttc cacttcacga gtatcattta actaaaacgc 660 aagcaaaaga gttattacca gaatcatgta cactattatc cactacacgt acaacgaaaa 720 caattcatgt ttattacaat gatttactac aaatcgcaat tgcagaaagc aaataattta 780 aataagagga gaaattaaaa tgacaaacgt aaaagatatt ttatcaagac accaaaaaac 840 attagcgaga tttgaatttg aggaaaaaga aagagtattt atcaaactat cagaattagt 900 agaaaaatac ggtatgaaaa aagagtatat cgttagagca ttatcataa acacagaatc 960 ccaattcggt gaacagggtg ttatgtcac tgacgactat aatgtaaact taccgaacca 1020 cttaacagag ttaattaaag aaatgagagc agacgaggac attgttgaca ttatcaacgc 1080 tggtgaagtt caattcacaa tttatgaata tgaaaataaa aaaggtcaaa aaggttattc 1140 aatcaatttt ggtcaagtat cattttaata caatttcata gggggtattt atcccctatt 1200 tttatgaggt gctaaacaat ggaaaaatat acactgccgt attattatac atgtatcaa 1260 ttaatgaac attgacat gaattgaac attcgaaaaaaaaa gttaggtaa 1320 tatatagtta tttgacgca aacttttaca aaaaaggtgc atataatctt tgtgtaaaat 1380 attaagga gcttaaaat gaaaattaca acaattaa acaaaaaaattaat 1440 tacattttaa ctaatagaga gtgttttatta aaaaaata caaatttac atcactaagt 1500 gataaatgtg tcgttttgt tagatacggt gatatttcta ttgaatacta tgatagtgat 1560 aaaaaaaaaaaaaaatgattt atttacttta gatatgacg ttgatta taaacatgtt 1620 tttaattgtc ttgtggtttt ttatcgagaa catttaaacc cactatataa aaagaagtt 1680 ttcacgggat gtactattga tgatgtatta gaaaatttg agaaaccatt agaaagttat 1740 attactatta tataccaaaaaagtcata tacgataatg ggaagtgat tgaacatgaa 1800 taacctatta aacatagcca ttgtattcct tttagcgtttt taattacac tgattatact tatgacactg catatacgcg tgtcattgg tgttttattc actacattga tattattcta 1920 cattatcttt ttagtggtta tatatgggtt atatggaggt cgttagcaat ggttagacat 1980 acgtccgaaa tggaataatg gaaaaaagaa agagacgcaa gaaagagca gaaaaaagaa 2040 ttgttttaa atgattttag tactgttaat ttaatttg atgataaga tttacagag 2100 gcgtatatag acgcatggaa acatttcgca catttgccct attttccaa agaaagaaac 2160 gtgtcatatg taaatgcggt atcattggta agaggtaaa gatatgacaca attaaactat 2220 atacttgaa tataaccg taagatgaa tctataata aaacgctaa aaaacataa 2280 tatgctttat atgaattaca agctaaaaat aaatttctt ctagtataa atatataag 2340 gaaattgaca ctttataca agaaattggt aaatcagaca gaccagtgac aactattgat 2400 gatgagagatg tgaggtataa tttttatat tatgcacat ttgaagacta atttattac 2460 tgtaaacgac atcaataact attataagga gcaaaaaaat ggtaaaaaaaccgtttag 2520 acatggtaag agattatca aatgctgtca atcatgtcag aaaaaaata accatact 2580 ataatcaat agaattagtt tagaactca tgaatgata tacatatcta 2640 tttcaaaccg ctctgacgga aaatcgttca actatgtttc atttttatt tatttagcta 2700 ttaaacttga tataaaattt actttattat cacgtcatta tacattacgt gacgcttacc 2760 gtgattttat tgaggaaatc atagataaaa acccactatt caaatctaag cgtgtcacgt 2820 tcagaagtgc tagggactat ttagctatta tctatcaaga taaagaaatt ggtgtgatta 2880 cagatttgaa tagtgccact gatttaaaat atcattctaa ttttttaaaa cactacccta 2940 ttattatata tgatgaattt ttagcacttg aagatgacta tttaattgat gagtgggata 3000 agttaaaaac aatttatgaa tcaattgacc gtaaccatgg taatgttgat tatattggtt 3060 ttcctaaaat gtttttacta ggtaatgctg tcaacttttc aagtcctata ttatctaatt 3120 taaatatata caatttatta caaaagcata aaatgaatac atcaagactt tacaaaaaca 3180 ttttttaga aatgagacga aacgattacg tcaatgaaaa acgtaataca cgtgcgttta 3240 attcaaatga agacgctatg acaactggtg aatttgaatt taacgaatat aatttggcgg 3300 atgataattt aagaaatcat attaaccaaa acggtgattt tttctatatt aaaactgacg 3360 aaatatat aaaattatg tataatgttg atacttta tgctaatatt attgttatac 3420 cttatacaa acaatgag tttgtacta agatcaaga tatagatgac atgttattt 3480 attagaga agacatgttt tataaagaaa acatggagcg ttattac aatccaagca 3540 attack tgacaatgca tattcaaaaa attackcgtggt tgataatgat agatatttat 3600 Attagatat gataaattt aaaaatttc attaaaaaa tgaatgag aaaaacatca 3660 acgaatttga aaaaaga aaaaatacg aagataacta tattgaaat aaagagt 3720 atttaatgaa acaatacggc ttaaaagg tgtgtagat tatgggatta cttgagtgta 3780 tgcaatca taaacatgaa cgtaaaatga tattgtattg ggatattgaa acatcat 3840 acataaaat aaacggacgt aaaaaccaa cgctataata aaacgtaacg tattcagtag 3900 cgattggttg gtttaatggt tacgaattg atgttgaagt attccctagt ttgaagctt 3960 tttatgatga ttttacaag tatgttaatc gccgtgatac aatcacaaa tcaaaacag 4020 attackatcat gattgcacat aactgtaata agtatgacaa ccatttttta cttaaagata 4080 ccatgcgtta ttttgataat atcacacgtg aaaatatata tttaaaatct gcagaagaaa 4140 acgaacacac actaaaaatg caagaggcta ctattttagc taaaaatca aatgtgattt 4200 tagaaaaacg tgtgaaatcg tctattaatt tagacttac catgtttttta atgatttta 4260 aatttaatat tattgataac tttatgaaa ccaatacatc attgcaaca ttaggtaaaa 4320 agttgcttga cggtggttat attacagacg accacttaa aacagatttt attacacga 4380 tatttgataa agatacgat atgaatgata gtgaagcata cgactatgca gcgaatgtt 4440 tttcaaact cacacctgaa caactatat acatcataa tgacgtgatt atattaggta 4500 tgtgccatat tcattatagt gatatatttc caattttga ctataacaaa ttaacatttt 4560 cattgaatt tatggaatcg tattaata atcaatgac acggttttcag ttactcaatc 4620 ataataaga tattaaata tcatatacac atttacatttt ccatgatatg atttttatg 4680 actatatca atcattttat cgtggtggtt taaatatgta taacactaa tacataaca 4740 aacttattga tgagccttgt tttctattg atatcattc cagttatcct tatgtgatgt 4800 atcatgagaa aattccaaca tggttatact tttacgaaca ttattcagaa ccaacgttaa 4860 tccctacttt tttagatgat gacaattatt tttcattata taagattgat aaagatgtat 4920 ttaacaatga tttattaatt aaaatcaaat cacgtgtatt acgtcaaatg attgttaaat 4980 actataacaa tgataatgat tacgttaata tcaatacaaa tacattaaga atgattcaag 5040 acattacggg tattgattgt atgcatatac gtgttaattc gtttgtgata tatgaatgtg 5100 aatattttca tgctcgtgat attatttttg aaaactattt tataaaaaca caaggtaaat 5160 taaaaaataa gattataatg acatcaccat atgattataa aattactgat gatatcaacg 5220 aacaccata ctcaaatgag gaggttatgt tatctaaagt cgttttaaat ggattatatg 5280 gcatacctgc attacgttca cattttaact tattccgttt agatgataac aatgaactat 5340 acaatatcat taacggttac aaaaacactg aacgtaatat attattctct acatttgtca 5400 catcacgttc attgtataac ttatggttc ctttccaata cttaacggaa agtgaaattg 5460 acgacaattt tatttattgc gatactgata gtttgtatat gaaatccgtt gttaaaccct 5520 tattgaaccc cgatttattc gaccgattg ccttaggtaa atggttatt gaaacgaac 5580 agatagata gatgtttgta ctgaatcata agaataatgc attgaagtg atggaaaga 5640 ttaaaatagc ttctgctggt ataccgaaaa acgcctttga tacaagcgtc gattttgaaa 5700 cctttgtacg tgaacaattc tttgacggtg ccattattga aaacataaa agtatctata 5760 atgagcaagg tacaatacg atatatcctt ctaaaactga aattgtatgt ggtaatgtat 5820 atgatgaata ttttactgat gaacttaata tgaaacgtga atttatta aaagacgcta 5880 gagaaaattt cgaccatagt caatttaatg atattcttta tattgaagt gatacggtt 5940 cattttcact taacgactta ttccagttg aacgttcagt acatacaaa tctgatttgc 6000 atatattaaa acgtgaacat gatgaataaaaaggcaa ctgttaaaat aacagttgcc 6060 ttttttttat tgagataca tgaaaaatgt gtacgaaaat tgatttagtt ttgttatttta 6120 ttactagca ttactagcat gtgttcatta tagcatacat ctttatgcaa tgccactaaa 6180 gabacaata ttcaccag cattattgg tacaccatta atgagtgaat acaataccac 6240 acgtgacggt gcaacgtatg gtggtacatt atagtttgct actaagaatg aaccatcgtc 6300 aaatactgcc actacaacac ctgtgtgacc aataccataa gctgttgctt gtaagtatgg 6360 tggtttactt gaaaaaccat aaccaacagt agggttgtgt gttgttttag cacctaactt 6420 tttataaaca taccacacac gttgaccgtt tgttatttgt ccgtcgtcgg taggttgtct 6480 tttaccatgt agttgcgaca tataagcca tgttaattct gtacactgtc ccgcattacc 6540 cgtttgagga aatatgttac cgggtttgta taagtattct tttttgaata aaggtacacc 6600 aattgctttt ttatattttt ctggtaactg tgcatacgtc cagttaccac caatgacgcg 6660 accactttta ccattaggtt tgactgattt accactaatt ggtttatgat ctccgtcatc 6720 atcagtaggg tttgaactac taccccact atctacttgc acgctatcaa tcagtttttt 6780 taatgaatcg agtagcccaa tagtcatttt aatatgatat gtgttgttaa atgttttttg 6840 taatgtaaaa taatcattac taaaaaattt gtcgctacct atactgtgta catcccattg 6900 taatgcgtct tgtacttttt ttaataattc ttgcatggct tgttttgcta aagcgagtag 6960 tgaactacca ctgtcaccac tactaccact gtcagacgtg tcactaggtg aaccaccttt 7020 accgtctaat tttccacccc atgctagaat agcatttgca ccgtctaaaa atggattacc 7080 atagttttgt actttattat atgatgcttt caaacctggt ggataatatg ccgcccaagt 7140 agctgcagct gttaatggaa tatacgcacg tccaattgta cctgctttca tatttttagc 7200 aaaatctgca ttaccttttc tttgtacgtc ttgtggtaca aaatgcactg gattaccgta 7260 atcataccaa gacggttgcc cagcttgttt tgattgtgat actaattttc ttgctatgaa 7320 tttagcgtct gttaaataat caccacgtgc agacgtatga tttaaccaac ctaaaccagc 7380 actataaccc tcattttttt catatacggc aaaaagagta ggtgatacac ctatctcttt 7440 tactgcttt aatacttgtc tgattttact ttcattacca ccaagccata cattaaagcg 7500 cccatatcct tttactttag ggactaactg gtctatcgtt aaaccgaaat catcattaat 7560 atacgaatgc gtaaatttat ctatcttctc ttggttgttc attattca ctcttttcag 7620 aatcattttt aattactctt aatttatctt taatttgttc tgggactaac acgtccattt 7680 ctgcacaatt ttctacgata gataacccct cattagcgat ataatagaaa atcgtaatca 7740 tgagtaagcc accttttaat tgtaaaatct ggtcaatgat gttagctaaa atgataatac 7800 agaatatcaa taatttttta gcaaaacctt tcattgattt tttagaccat aagttattat 7860 ttttaatagc tttagcaaaa cctgtgataa catcaataat cattaaaaca aataaaaagt 7920 atagtaattt taaatcccca gcatatataa acatgtgaaa cgcttctgag tctgtaaatc 7980 tgaatttac ttcgttcata ttataccccc tctctaaatt tgttatttaa tggattttgt 8040 aacattggat tacctgaacc gtcattatgc caaaatctca caccagattc taaaattgct 8100 tttaattgtt ccattaacat ggggtcaatg tcacgtatgg tatacgtacc tgtacatttt 8160 aatagttgc aaacagtcat actgttaatt ggttcaataa atgaattata gtcattcact 8220 tcaaaaccaa acaacatata atatttttgt aaaaatgtaa tttctttagg tgacggtaca 8280 ctaatttca tcgttaaacc gttaatactg tttgcaattt ggaatgcgtt gcccatttcc 8340 gactctgtca ctgacggtgg ttgtaatgct aaatctttat attctgcttg ttgttgtttg 8400 tagaaattat attcttcatt aaacttacca aataaagcag tcggacttaa attacttgct 8460 acgctcactg cgtcataaaa acgtgatttt ggatcacttc catttaatac attatttata 8520 cgacttgtga ttaattgact ttctgcatta cgctgtctat tggcttgttg tgattgtcct 8580 aaaattccgt tattaattaa tataggtact tgcgcaaaac tattaaatgt tatatttgta 8640 tttaagaatg aacctgtatc aattaatata tctttatttt tagcaagtat cggtctatcg 8700 ttttcagcac tgtataatc tactggatat actcgcactt cattatgata accaatgatt 8760 gactttgtac gtaacttaac acctgtttt tgcgaaatct taccagcgtc tagtaacatt 8820 gtattaccgt tccagtcata aaattcaatc gtcatatact cattacgtat catatgttta 8880 aactcttct ttttagacaa catcatttct tgaagctttg tgaaacttaa tgataaatcg 8940 tttaaactcc attctttga ttttccacct tgttttaacg tctttaatcc agtaattttt 9000 tcacttgtct taacgtcctc taaatctttt gtattaataa agtctttagg taacatttga 9060 accttttgaa agttttgtgt aatccatgga tatgcactca tttatccat aaaattgata 9120 aaatccccgt attccataac gtataagttg actggtgat tgatattgtc atatatcgta 9180 cctttagacg tatctaagtt tggcttttt ttcgtaccaa atttctttga taaatcagcg 9240 cttgactgga atacactaa attttctaaa tactgttgca ttggttata cacatagtttt 9300 ttatttgata cttttacac atcatcattg tggtacat atagttatac 9360 gtgcgttttg ataagtgttg acgttcaata ttaacgttg agagttgctc taatacatta 9420 ccttgtgtat acgtcataat agtatcaatc acaaaata ttttaccac aacatcattc 9480 acatattcga ttgattcac aaagcataa taacgtctgt cctcaaaatc tgataaaaac 9540 gtcatatagt taatcccttg tgcgtcatgc cactgcatat ciecattgat ttccattcta 9600 tcacgtataa aattatacgg ttgtttggaa tagtctaatg atttaaaatg acgaccattt 9660 aaaaaataat catcacgttc tttacta ttaaaatgaa tcgtgttttg ataatctgta 9720 aacggtgtgt tatagaaaaa tttaaaattt gttaatttc tcattttac ctccataaaa 9780 atagtcgtat aaatttatta tacgactatt atacatttt tattcaatga ttgtgtgtc 9840 tattgcaaaa cgtttatcac catttgttaa gtcactatcg ctataatttg atgtaacaaa 9900 atgtaagtta cccttaaagt ttaaatacat tcttgtattt atcattttat tatcaacagc 9960 acattgcgtg taatgatgtg ttgattttaa atttgcgtta atcgtaccta atttaatatc 10020 accgttttta ttaatccctt taaatacacc ttttaattgt attgttttta tgtcattgat 10080 tgtaacaatg cgatatttta aaggtggata agcattacta ttataatctg ttgtaatacc 10140 actttctaat tgtatatttt gccaacctgt atcattaaat tcaactttta cactgttaat 10200 tttttgatta aaattttgtt caatttctga tttggattgc gcaattttag tatcaattaa 10260 attaatttca tttgtattac gtcctacact atctttagta gcgtttaatg attgtgtaag 10320 tgtgttatat ttatcatcat actgtaacat tgatttttca aattcattta attgtttttg 10380 atgttgttct aaactttcaa ttaatatgac atctttttct tttaatgcgt caatgttatt 10440 tttattacta tcaatcattg gttgtaattt ttttatcttc tctaaaaatg ttgatatttt 10500 ctctttgtta tcattaattg caatatcatg tttatctatt tgaccactat atttatcaat 10560 caatgttttt aaatcattat aaaacgttaa cttataataa cttgaatcag tacggacata 10620 aatatgtccg tctgatgtac taatcaagtc attttcttct gttaaaaaat ctgctaaacg 10680 ttctatatct tcgacacgtc ttaaacttct tacgattcta tcagccattg tttacacctc 10740 ttatttatat cgtttccaac taaactcaaa gaaaaaacct aaaataccca ttatgagaac 10800 accccccaaggaataccaac actgtaacta ttacctgttt taccattcca ttgccttact 10860 ggtaaataat aacgtgtacc ttgccagttg taaccaatcc aaactaaccc atctgataaa 10920 catacttcgt catatggtgt atatccacca ggttgaaacc agtagccgtt aggttctgat 10980 aatttaggac taccaacatg tgcaaatatt ggtaaaaagc cacatgtaaa tgttgcattt 11040 tcatttctgt aatatgtacc gtattgattt tgtttccagt tgttagtttt ttgaatattt 11100 tgttctaata ctttactatc actatttgaa aattttggac gaataaaatg cgttacaccg 11160 tcataataat gggtgcgtat tgtcgctttt tcccaaccgt caaaaccgcc attcaaccag 11220 ttttgctcta aacatgtata ataatctaaa ttcccactta ttacacattg gatatgacca 11280 tattgagaat tagtataaac agcaacatca cctaattgag gtttaaagct cggtgtattt 11340 tcatacaccg ttgctaaacc tttaaagtta ttattaatag cgtctttggc gttaccccac 11400 atgcgaactt taccgtcggt aatgtaataa acataagcaa ctgctaagtc catacattga 11460 aaaccatatg cgccatcaaa gtcaacgcca acaccctcat gtttatatat ccaatctttc 11520 gcttgttgtt gtgatttcat ttatatcact cctatttttg atgttttggt acccaatcat 11580 attcacgatg tgtatttttt actgttacaa gactataaaa ctctttatat gttgatgaat 11640 ttattaataa cgtttgtcta acttcacctg aaacgttacc acttgatact tgtaaccatg 11700 caccagcttc accaatatct ttaggtttat ctttaaagtt attcatttgt gttgatgtaa 11760 tgtaatattc acctggtaat gtaattttag caatccaata accaaaattt ttagcctcta 11820 cgtattcttt ttcagttgaa ttagtatcaa taacagacca gttaccaaat tcaaattttt 11880 gtgtttttaa gttatatgtg aaacttctta ttagtttcat catttttctt aatcctgagt 11940 ttcttgttaa ttcttgatat ccacctaact gttgtgtttt tggtgataca aataaaaacc 12000 aaccggcatc attattgata tatggaaaat catccataac tttagtatgt tctgtcatca 12060 tataataaaa tccagtttcg gtaatttggc ttaaacttgt tacaccatct cttattgata 12120 aagctctacc gtcatctttc gttagttat agttttgccc accttttaac gttaatccta 12180 caaaacgctc atattcacca gtttgaaaga aaccatacaa tagttttgt ctttttccac 12240 caccagcagt tgtatatgca attaataaag attgtttttt agttctagga ttaacgtata 12300 aataatcc ctcaggttct ctaaaattat ctctaggatt ttcaacacca tgttcaaatg 12360 aaacatcgtt taaataataa tcgtatactt ttgatttgt tttaaaacta tatttttgaa 12420 ttaatgtttt actatctagt tctgaccaac cacttaacca gtataaatca tcaccataaa 12480 ctgcaatacc ttgcataggt ctgtctggtg tgttttcttt tacatcaatt tgtagttctt 12540 tttctacatt gtcaatgtga ttaattacat cttctcttga ccgtacttgt attaaaccac 12600 caccatatct aataactaat ttgtcatttt cttcatccat aataggcgta aaatattcat 12660 gtgacgatgc tggcgtgaaa tcagttaatg cttcgcatc atctactgtt aatgttgtat 12720 tatctctata agcgatttgc acaagttttg aaagtgcaac atgatacaac catattttta 12780 tctcaccgtt actttttctt tctaaagcaa tattagtacc atgaccaccc tctacaatat 12840 gcatactaga aattaaatca ccactaggcg taaatttgtt aatccaaaaa ccttcttttt 12900 cttgtgagtc ggattgtgta gagtacattt gatttgtttc tctatcaatt aatacttt 12960 ggttacagc gttacgaaca ccaccaaagc cagttacaaa cttttggttca agctcattta 13020 attcaaaccc attaacgaaa cggtcaatgt cttaattaa gtctttcact tctgctttaa 13080 aatcattcat ttgtttcatt tctgcaactt taaataatgc aaacgccgat gttaatcctg 13140 cactatatttt tttaaactcg tcatgaataa tgttatcaat cgtaccatcg tttaaccaac 13200 ctctaaataa gtctttcgct tggtctggga atgctttcat taagtcgtcc cagtttctaa 13260 aacgtttttt taactcaccg tcatagtccc aatacgacg tgctaatact tcaattagtt 13320 ttgataatct tgaaatataa tcataatacg attttgaatt tgtattataa tctgctctat 13380 catcgtaaaa cggtgtgtaa cgttctctag ttttatatat ttcgtctaaa aatggacgaa 13440 tgtcatcaaa atatttaaaa tcgttttcat tatatgccat aattttccac ctttaccaaa 13500 tttgtaaaaa acatttttta tcaaattcat ttaaaatttt ctttcttaaa tcgtatactt 13560 tatcaatatt atcaattaaa tactgctttg aaaattgtgt acctttcgca ttaccttttt 13620 gattttgatt acgttttgcg ttttgattac tttcgttact tgatttattc acagttttac 13680 cgttatcgat tgtattatta tcagcaaatc gtaacgttgt attatcaaca tcaatgttaa 13740 cctcactttg tggcagtgac acataagcat ttctgtttgc tgtcatccca gttgaattgt 13800 ctaaagatgt agcattttga ttcgatgttt catcagtatt gcttgttgta tcttcattat 13860 gttctgtaaa accttgtgat tgtagatatt tttcaacttc tcttgatgaa taaaccacat 13920 tcaaataatc ctcatgtgtg atacatacag taatcacttg catgccaaaa gcttcaactg 13980 tttgtctgtt gatttctcta tctaaaaagt gtattgtaaa tgatttttta aaagtaagt 14040 cagataagtc atctttaagt ttaaaacctt taaacacttt ttcattaacg atggctaaaa 14100 cgtctttgtc aaacttcaac attttgca tgaattgaaa ttcatcatca taaaacgtta 14160 atttatcatt atttacaat tcattaaaac cttttttaat taattctgat ttataaaat 14220 CAAAAGT cattgtatat ctagccattg tattcactac ttcatcatt agacaatgta 14280 tctatcattg ttatttctga agtaacttca tcgtcgtaat acggtttaat atctaaacca 14340 taacgttttg atagaatgt aatcggttca cgacctttta ataaatatt actatttgat 14400 gtgtaaaac ctcggttgct tttgctct tcgtccgaaa caccgctttc cttatccact 14460 gctagtgaat taatacctaa atagttactt aattcactaa ttttattg gtattcgcgt 14520 ttcatctcag ttagtgctg atcacacta ttactggtta aatctgat atcatcatcg 14580 gcgttaaaca taggtgacat ttacaaat ggtgcaccgt tatatatttc cgatacaagt 14640 tgattactg actcatcatt atgtgat ttaatattt tgctaattt tgcttgcata 14700 attaatgaga atcgagataa aaacctca gataattcat cagtataatg ttctatgatt 14760 tctatatcac tattatattg aattggttta ttttgcatga caacaaagtt accactcata 14820 cagttatcat atattttatg aatctgtaag cattcatctg gtattaaata ctctggtaca 14880 atgaaataaa tatcatcttt tgttaatcgt ttttgaaatt ggaaattaaa gtttgatgaa 14940 aaatttggtg cttgattaaa gtaagtgtta tttacataac caagaatcat aatttgctta 15000 tttctagctt caccaaccac tacattgatg ttttgctta aagctgattc taactgaata 15060 aaatctatac caaccgtatc acgattggta tagttgatga gtagcggtaa aaattccaaa 15120 taacgattaa acataagacg tttaaatctg ttgcgatgtt ctacaacacg tttattgatt 15180 tctttagata attcaacctg tacgccttta ttatgtttag tcatttatag cacctctatt 15240 attctgttct cggtgtaaca tcttggtcag taattaaaat tttattaaag aatgggctaa 15300 tggctttaaa tgaataataa tgaatccagt gtgtgacttc atcaaattca ccattataga 15360 atggttgttt taacatacct ttgtgtaac gtttatattt aattgaatta atatccaaaa 15420 taaacgcata taaatctgat ttggtttta ttctcaac gttagactta aattcagata 15480 aatttgaac atcatagtg atactgaac caacggaat tgtacacct ttatgagtttt 15540 gatacacc gtaagcacgt aagaattaa ctgattcgtc acttgaacg acaatctt 15600 tagtaacttt aaatactcca cctaatcat caaactaat aacgtggtct gtaagtca 15660 tccctgctac ttggaacgtg tgcgcaatct ttgtatcta aagatagat tttaagctat 15720 cagtcgttaa aaacaata tcttttaatt ttgaaactgt tgtatattgt ccaatagcac 15780 cacctgaagc acgatgaact tcattatatt tagcactgtt gttttgtag tgagaatag 15840 cttcaaaaac tttacttgct aaatctctt ttgatgttgc tttacgtaca ttgattcag 15900 ataattgatt caatgagtaa tcactaca tgctcgcat ttctttct tctaatacgt 15960 taatatcaga aattttcttt ttatagacac ctaatgcata attagttgcg tctgctaatg 16020 tttggaaattt gaaacgtgta tcattgttat ttaatgtgaa ttttgtttc ttcacaatac 16080 cactaccata taacttagta gccatacgtg gataattacg ttttagcatt aattcttcat 16140 ttttagataa atccatgtta ataggtacag tatccataat tacatattct tcactgtatt 16200 gtccgataaa gtcttgttct ttagctaacc attaaaacg gttacctaat gcaatatcga 16260 ttaataacgt ttcattaatc ttagggaata aaaatttatt tacaaatgtt tcaaacattg 16320 tatttgagtt atcccactta tcgccaaacg tccatgattt tgaataagta tgattaaagt 16380 cttgtaatgc agatttagct gacttagcaa ctaatagtgc tgttcgttt tttgtaatat 16440 tttctgccat gatttattat tcctcctcta catcgccagt aaatgactgt tttgaaagtg 16500 aatgaatttg tacaccataa ctatcttcac ttttgtttgt gtcaattgac atattttcat 16560 ttaattctgt tcgtttattt aatcttgaat cttcatatga tgtacccatc attgaacgca 16620 tattgtttcc ctcatacatg tttaaattcc tcctaatcta aatctaactt ttctattaat 16680 tcttcatctg aatagtcgtt atcttctttg tctgattctg ttacatctgg ttgtgtttgt 16740 tgtacttgtt gtggttgttg catttgtgaa gataaataag tagttacttg ttgttctaat 16800 gaagtaatac gctgctctaa tacaacaggg tcaaatttag aactatcttc atctgttgta 16860 gtaggttcta atttgttttc attttcttct tcgattgttt ctactgtttt atcttcagtt 16920 gattcttcag ttgattcttc agtagattct tcagttgatt cttcagttaa ttcttcagtt 16980 gattcttcag ttgattctga agtttcttct ttgtcgtctg gttttacgat ttcatcaaat 17040 tctgtcattt agacacctcc aaatatttta taactaatta tatcatagaa tatttaaata 17100 agtaaaataa ttttattata tgttcaaacc ataatttttg ataaaagtca atagatacat 17160 aaattttgta tttgatgaat atgtaatagg ttagataagt tggaatagaa gtt 17213 <210> 2 <211> 134876 <212> DNA <213> Artificial Sequence <220> <223> PN1483 <400> 2 aaaacctata gaacctgaaa aacctataga acctgaaaaa cctatagaac ctgaaaaacc 60 tatagaacct gaaaaaccta tagaacctga aaaacctata gaacctgaaa aacctagctc 120 agatactacg atacttttag ttccattgga acctagcaca cctgtagatg aaagtaatga 180 tactaatgga gaggtaac ctctcctttt tttgctatat taaaagagta aaataaa 240 cattatagtt ggtgattttt tgataggatt aaacgtactt acagctatat ccgtagtttt 300 tgcttgtgta agtctactag cactaatgat atttgcgtat attaaaactg aaaaaagtag 360 taagttggtt ctatacttga tatatgctat aatttctata ggttcttatg tagtattac 420 aatgtttcaa gccacgtcaa tcattataa aaatgatgtt atagactcta ttgagaatac 480 agagcagtat gtagggttta aacccttt aattgtttt ggtataagtt tctttggagc 540 tgtaataggc agttttttggt ttttagttat gagattgta atactagga atttaaaaaa 600 taaaaaatta aaggattgaa gcattgcta tttcaaag acgaataatg ggatgaagca 660 aaagacttta taaaaggtca aggattagca gatattga tagattagt ggattactat 720 agacagatag gtggtaaca tgtagctatg tttattgcta ttgataagt taaatatatg 780 gtactagaag ctacaaagga taataagta atattggtag aataggaata taatattgtg 840 ttagaggatt atgatattgt tatggaagt aagaaaatgt tttactatat agaagaacca 900 ttcgaagtaa agataaatat tcctaaacat atccagaca ttacctataa taacactgtt 960 attackacta ctattcgagg aggtaataa aaagttgccct gatttatta aaagtctaag 1020 gttaggtagt atgtataaag agacactga agaccttatg gttcctatag atgacggaat 1080 acaagctaac attagaaa window acaagctac attactaac ttactaatc 1140 tttgtatggt aacagcaag cttatgcaga accatttta gaatgatgg atacaaatcc 1200 tgattataga gatagaga gttattagag aaatgctcat atttacatg aagtgttaaa 1260 gaaatttggt aaactcta tactaatgc tataattatt acaagagcta atcaagtac 1320 tacatactgt aaacctgcta ggtattcaga agaggagtg ggttttgag tttaattaa 1380 agacttagac gctacaccctg gttaaaga aaagaacag atgaacgta ttgaagaatt 1440 tattcttaat acaggtacag aaagatat agacagggat tcattccaag agttttgtaa 1500 aaaaatagta agagatactt acacgtacga ccaagttaac ttcgaaaag ttttagtcc 1560 taaaaaacaaa actaagatgg agaagtttat tgcagtagac cctagcacca tttttatgc 1620 tactgataaa aacggtaaga taattaaagg tggcaatcgc tttgtacagg tcatagaataa 1680 gcaagtagta gctagtttta caagtagaga acttgtcatg ggtattagga accctaggtc 1740 agactaaat tctagtgggt acggattgtc agaagtagag attgcaatga aagaatttat 1800 agcttataat aatactgaaa gttttaacga taggttcttc agtcacggtg gaacaacaag 1860 aggtatctta cagattagag ctgaccaaca gcaatctcaa catgcgttag agaactttaa 1920 aagagaatgg aaatctagtt tttcaggtat aaacggtagc tggcaaattt gcctctatat 1980 aaagtaattt gtatagatga agggttaact gctaagaaca cctaaagctc aatacactac 2040 aaagtaaccc gaaagggtag gcttgaatgt tacgaaagta gaaaaaagat attgagatac 2100 gttaaggtta aatcctaaga cgaagaacaa tggttgttta gcatcgaaag tcctaaagaa 2160 ctgaaaggtc tatggaatac gttcaacgac tatcccgtta caagacggga gtaaagctcc 2220 aagctattgg gagaagaaaa atccttaccc tacaacatag ggataacaaa tagtctagtc 2280 tcgtactgaa aggtagagca tgtgaaataa cacaggttta caagtagcg tttgtaaata 2340 aaaaaacta agtttataa aaaaaaatta ttcctttact agttgacaag taatctttc 2400 tatgatatac ttaaccata gaaagggtt gaagtcaat gagaaaccata aattagat 2460 tattaccac tccagagca gagacttaa tgtgggttca tgtaatcat acacgtaatg 2520 ttaaaaatattttagct aaatgttttg actaaaaga aacaggagaa tttataagta 2580 aaaccacatc aaaaaacta agattagaat taacggaat gttgaaaca gataatata 2640 gttatttaa aagtgtatca agagatacac tagatagagc tgtaatagt gtagttcaat 2700 cttatgttga ttggtgtaga ggtactcatg gtaaacctaa attcaaaag aaaaataaat 2760 gtacaaaata ctttgatgtt agggaaaata gattaaaag gtatggacat acttttcata 2820 tacctagtat aggaaagtt aaagtactcta aaatacttt aaagaatat tttagtatta 2880 taaattctat agaaagttta gataaattta gaaaaacatc tattagtat gatggtagt 2940 attggattat gtttattact tatgatgaca catagttac ccctcgaaaa ccagagaat 3000 tatctaatga aaccataggt atagacttag gtattaaaac attagccact tgttctaatg 3060 gtaatctta taaaaatatt aaaaagtt ctaagttaaaaactagaa aagaattat 3120 ctagactaca frequency ctagactaca frequency ctagactaca frequency 3180 ttaaaactaa taatattatt aagttagaaaaaaataa actcttacat agaaactta 3240 gtaatattag aaataatcat attcatacta tgactaaga atagtagaa caatatccta 3300 gtgaaatagt atagagac ttaaggta gtaacttaag aaaaaaaaaaaaaaaaaaaaaaaaagateded 3360 atagtatttc taagctaat tggtataca ttagagata ccttactt aaatgtgaag 3420 atagaggaat attacttact attgctaata cttactatcc gtctagtcaa acatgttcta 3480 attgtggtaa tcgttttaact aacaagata actactcttt atcacaaga acataat at 3540 gttcttgtgg aagtagtata gatagagatt taaacgctag tattaactta aagaactata 3600 gatactccaa ttggtatcac aatcatgttt taactaaatc aacagtaaa catgatatgt 3660 aggattccgt aaatccgaat taacccttt ggagtatcac acaacctga gtagagtata 3720 taaaagtagc tagtaagt gagatactc aaaagggat acgttgaaaa aggaataaa 3780 tttttataa atttttagatt acgaagtccc cgtgatgatg gctgatgatg ttaagttttgt 3840 taatatgaca ccaacagcaa atgatatgca atttgagaaa tggttaaact ttttaatcaa 3900 tattattct gctttgtatg gtatagaccc ttctgaaata ggattcccta atagaggagg 3960 aggagccaca gggtcaaag gcggttctac attgaatgag tcagaccctg ctaagaagca 4020 acaacaatct atgaataag gtttacaacc tctattaga ttatagaag attatta 4080 cagacacatt atatctgaat ttggtgataa gtatactttc caatcgttg gaggagatac 4140 taagtctgag ttagataagc ttagtatttt aaaaagaa gtacaagtat aaaactgt 4200 aaatgaagca aggagaac agggattga accaatagat ggtggagatg taatctctga 4260 ctcagcatttt ttcaxaagta caccacaga atacaaaa gaccaatacc gatatacta 4320 aaaaagaa agactcaat tacttagag ttatacacaa ccacaactg atgagcctac 4380 agatgatagt aaaaaaaaaaaaaaaaaaaaaaaaaaaa haveaa have ctactaatca agagtagg acagatacc agtaaaagg 4440 tgatgataac gtatagaa stormc aaaaagga aaggtgagaa 4500 atcttccgac tttagtaga taatattagc aacctatta atacttaggt tgttattttt 4560 taatttggag ctacatttat actatgttat actatgtgtg tagtaatgaa taatgttgat 4620 gatatacttt ttgttatatt atgtatgtac ataaaata acattaagt gaggtgtata 4680 atcactttgg aagaaatgaa atttaatgct ttgttccta tggacttaa gaatccata 4740 gatacggaag atgatacaa taaatattct atcgtatctg gttggggctc cacaccagct 4800 gttgatttgc agaatgacat tataaatcca aaagtattg atatagaata ctttaaaaaa 4860 aatgatata ttactacga acatcaaca gatatgtag taggtatacc tacagataac 4920 tgttatgttg atttagaaaa aggtttattt atagaagcta agctatggaa agatgatgaa 4980 aatgttataa aatgttaga cctagctgag aaactagaaa agtcaggtag tggtagacgt 5040 ttaggtttt ctatagaagg cgctgttaag aaacgtaca taaatgaca tagattgtt 5100 gatgaactta tgattacagg ggtagcacta gtaaaaaacc cagctaatcc tgaagctaca 5160 tgggagtt ttgttaaatc attccttact ggaacggaaa cacaccaga cacacaagta 5220 gatgcaggag ccttacgtaa agatcatta gcaagctcta ttactaattt aacctagta 5280 aaaaaatta aagatgttaa agagtataat gatatttgga atatgtagt agaggactta 5340 actaaatcta attatatggg ttgagaa tcagttatta cattacatt agccaagg 5400 ctatcaagaa aagatgctga gatagcagtt atgagtatta aaaaaaaa tttagaatag 5460 gggattatat tatatgccta cggaattaca aaatattcta cagaatg atacttaga 5520 aaagaa gtatcaaat ctgtagaga gtctaagaa gaagtaaag agataaac 5580 agagacact aaaaaaaaaaaaaaaaaaaaatt aaaaatgag agagctac 5640 agagagcaa gtagcaagg ctaagaagg accacaaa cctgcaagg ttactgaagg 5700 agatgctaaa gagcacatg aaaatctagaa gagaagtat ctaagtcagc 5760 taggagtcg aagaccctg tagaaaa agatactaaa agagaca aagahaaaa 5820 gaaaaaaaaaaaaaaaaaagaaaaaaaaaaaaaaaaaaaaaaaaacal 5880 atctaaatct atttctgata agatattgt agatggtttc cgtactatct tgaaatcatt 5940 ccaagacatt aaaaagaaa atgaacaat tgtgactaaa tcagatttag aagaagtaac 6000 taaatctatt caagctttaa ctgataaaat taattctaat gagaagtttt ctaatcagt 6060 tgagagcaac cagagata aagagaagc agtagaaaaa tccgtaacga ctaatacac 6120 ttcgaatgaa caatgtag ttggttgt agctaatca gtacaacag aagaacaagc 6180 agaaactaca gagataag aaaaaaaagaagaaaa gtagagactt 6240 atctgtagaa gcccgtgaaa attcatgag tacctataaa gaaaaatctc aaaacccaca 6300 tacgaatcgt tcagaagtat tgaatgctta tcaagcttac ttaataatcc gcaacaatcc 6360 agagcaagca agtgaaaag actttaat tgtaaagaa ttgctaatc tttattag 6420 aaaaaaagtt gtgttattatt atagtgtgta aaaaaaaaaaaaaa gagcatatat 6480 gaaggtgat atatataat gaaccaaat gaactttca aaagcaca tgcagttgct 6540 gatgaattac aagaaaaatt atcgaaatcc ttccaactg gatatggtat cactcctgaa 6600 acacaagtgg atgcaggtgc tttacgtcgt gaaattttag acgaccaaat cactatgctt 6660 acatggggaa ataatgattt agtattttac cgtgatgttg cacgtagacc agctgaatca 6720 acagtaatta aatatgatgt tttcttacgt cacggtaaag taggtcattc tcgttttgta 6780 cgtgaaatcg gagtagcgtc agtttcagac cctaatatcc gtcaaaagac cgttacaatg 6840 aaatacattt ctgatactaa aaatatgtca ttggcatcta gtttagtaaa taacattgct 6900 gaccctggtc aaatcttgac tgaagatgct atctcagttg ttgctaaaaac aattgaatgg 6960 gcttcattct atggtgatgc ttcattaact tctgaagttg gtggagaagg actagaattt 7020 gatggactag ctaaattaat tgatgctgat aacgttatcg acgctaaagg tgctcactta 7080 gatgagaaat tattaaactt agcttcagtt aaaataggta aaggttttgg tacagctaca 7140 gatgcttaca tgcctatcgg tgtacattct gactttgtta ctaatatttt aggtcgacaa 7200 atgcaattaa tgcaagacaa tagtggtaat gtaaatactg gtttcagtgt taacggattc 7260 tattcatctc gtggattcat tagattacat ggttctactg taatggaaaa tgaattaatc 7320 ctagatgaaa ctttaatccc acaaccaaat gcaccacaac cagctacagt aactgctact 7380 gtaaaaaacag accaaaaag taaatttact aaagaagaag accgtgcagg tttatcttat 7440 aaagtagttg ttcactctga tgaagctgaa tcagcaccat cagaagcaca agttgctaca 7500 gtaacaaatg ctacagatgg agtagaatta aagattactg ttaactctat gtaccaacaa 7560 agcccacaat tcgtatctat ttaccgtcaa ggtaaagaaa caggtatgta ctacttaatt 7620 aaacgtgtag cacttaaaga tgcacaagaa gatggttctt tagtattcgt tgataaaaac 7680 gaaacattac ctgaaacagc agacgtattc gttggtgaaa tgtcaccaca agtattacac 7740 ttgttcgagt tattaccaat gatgaaatta ccattagctc aaattaatgc tagtattaca 7800 tttgcagtat tatggtatgg tgctttagcg ttacgtgccc ctaaaaaatg ggctcgtatt 7860 aaaaacgtaa gttaaccttgc attaaatag taaatacaat taaaaattga atacaataga 7920 ataaggagta tacctaaggg ttgctccttt tttatacta cttatagtat acacgaaagg 7980 aatttaaaaa tcaatgttaa cttataaatt aaaaaatatt aaaatggcta ctgtacatgg 8040 tcaagtaaga gtagatgata aaggcgtagt taaagatta actgctaaac aagaaaaaga 8100 ttttgctaat ttaccaggtt ttacacatat ggagacaag aaaacaacaa agaaagaagt 8160 aaaacctaag gaaaaag aagagaagag accaattaaa aaaacaacta aaaaagaaga 8220 tagtaggtt gatagaatgg taaacagtat gtttggtggt agtttagacc cttacgaaag 8280 ctctttatca tatgagtatc cttatcaccc atctggaaac ccaaaacata tagaaaaag 8340 agaattagat agtattactc tagctgatta tggttggtca gcagatgctg tgaaagccta 8400 catgtttggt ataacagtac aaaaccccga tacaggacaa cctatgggtg atgattttta 8460 8520 8580 tgtacacgca tataaaaaac ctatattaca ggtagaaaat ttacaactac aattaatgg 8640 tagacctatg tatgattatc cagctaactg gtgggaaagtg gagcatttag caggtcacgt 8700 acagttattc cctacagctt taatgcagac gggtcaatct atgtcttatg atgctgtatt 8760 cagtggatat cctcaattag caggaatgta cccaccaagt ggagcaactt ttgcacctca 8820 aatgattaca ttagattata ttagtggtat gttacctaga caaagagcag gtagaactaa 8880 accatgggaa gtaccaccag aattagagca attagttat aaatatgcac taaaagaaat 8940 ttaccaaata tggggttacg atgatattac cctgtgtgta gcgtaagttg cacattttca 9000 aaggttaact gctaagaaat cctaaagcta actaaactac aaagtaagtc gaaagactaa 9060 gcttgaatgt tgagaaatca gaaaaaatta gttagatact ctaaggttaa atcctaaaga 9120 gaagagcaat ggaagtttag catcgaaagt cctaagtcaa tagaaagga atacgttcaa 9180 cgactattct gtatagacga cagaagtaaa gctccaagtg attgggagaa gaaaaatctt 9240 taccctagtc ttagggataa caaatagtct gcacacgtct tgaaaggag tgctaggaat 9300 tgacctagac ttattagta gcgtaagtaa ggaaacaatg ttaattaaat gaaaacttcc 9360 tattgaaatt accccaagta tatgttatat tatagatata atatataagg tggtgaaagt 9420 aaatgaaaaa aacggaaaat acatttata gaggtataac actaaaagta aaccctaccc 9480 aagaacaaga aggttaatg tggaacatg taaaccattc tagattatt tatatta 9540 tgttagaaag atattggaaa gctctcgata acggtaaata tatagaccat aaaataatga 9600 tttctatatt aaagaaata aagaatgatg ataagtatag tttctttaat gaagtatcta 9660 gaaaaacctt agttggtaaaatagatgact taagagaac attaataaa tatcataatc 9720 atgaattag aaaacctaaa tttaagtcta agaaaggga atctaagagg tttcctatta 9780 gatatgaccg atgcacttt aaaaagaaaaacatgttaa agttgaaaa ttaggttact 9840 windowsttc taatggtaca taaaaaata aatcagt actagagaat gaagcatta 9900 aacctttaaa ccctaaatgt tactatgatg gtaaatattg gtatatatct tttcaattg 9960 aagtagataa tcaatacaag aagaaaagg ataatactaa cgaagtcata ggtatagact 10020 taggtagtgg taaaaaacac gtaatttgtt ctaacagaaa atatatggt atattattt 10080 attccaagaa atgaaaagg ttagaaaaaa attackctga cctacagaaa agattaagta 10140 aataatatga tattacac accaaaaaaatgtttt aaagctaga aaataagatag 10200 ctaaagttta tagaaaatg tcaataatcc gtaaaaatca tgtacatgaa atacaaag 10260 aaattgttga aaagtaccct aaagagatta ttgtagagga tataagagtt cgtgatttaa 10320 taaaagacaa agatataca ggacaaaaaa gaaaacaat acagttttct aatttctata 10380 tgattagaca gcaattaca tataaatgtg aagatagagg tataaaattt acagtagcta 10440 gtacttatta tccatcatca caatatgca gtaattgcgg agaaagaaa agaatgctt 10500 taaaattaca gttaggtgat aaagtcttta aatgtaatgc ttgtggatat gagagata 10560 gggatataaa tgcaagtatt aatttaaaaa attaccataa ttcccaatgg ttaaaagaac 10620 aaaaccaata atatgtttgc ttttagtagg gttccataac ccgaatgtat aatgcccttt 10680 attttacaa ggagttaat ttattaca tattgtaatc tcattacgg tgcaggata 10740 gcaaacaaaa ctctagatgt agatggtatt acagaaaaa taggtactac acaatctgct 10800 atgtatggtg gagcaagtgc tcaatacta caatatg agatataa agagctatta 10860 gctgggttaa atcttactt tggctccaat atgataggca tagtagga aggatatt 10920 aaatgcaaaa accttttatg ataggtacta ataataatac ttctaatata attaatagt 10980 ctactatgta tacatctaca acacaagcag atgaaagtta tctacagcta 11040 gactgagtt tgacataag gattgaga gatttgtca tgatagaggt ataaggtac 11100 tgtgggaaag agcttacttt tgtccttgcc tttaccctga cacaggacat cctagagtag 11160 attgtcctag gtgtcacggt aaagtattg cctattacc tcctaaagg acaataatgg 11220 ctattcaatc tcaagaaaaa ggaactaaca atttagatat aggaattta gatactggta 11280 cagctatagg aactacaca ctagaaaaac gagtactta tagagacagg tttactgttc 11340 ctgaagtatt gatgccaca cactatat accatgttac taagagcgt atacaaag 11400 gtattccttt gtattatgat gtcaagaag taacttttat tacatctaac gatggtaatg 11460 tttatgaaga tgactataat atagagaca atagattatt catggacgct aagtttgaaa 11520 aaaaactgt atccttaaat attttaatgg tacttagata tgtagtaca gatatattaa 11580 aagaaagtcg atcaat actaaattta atcaaccta tacaagtttt gaaaatttac 11640 ctcagaagct attattaaaa agggagacg ttattgtact acctgagcca ttaagtta 11700 atgatggtat agagaggac ttagagatac aggtagaa ccctaaaaa gatctaaag 11760 ataatcattc aggtggtttc tttggaggaa tgctataatg cctataaaag caacgacc 11820 tagttattt agagacacga actataaaaa ttagttag agagacagtag atgttatgcg 11880 ttctgatatt ttagatagat tacaagctac agcattacaa gtagataatg taagtgtca 11940 acgcatgcct acttactac aaatactga gaaaagcta gagagcaag gtgtaataga 12000 ccttaagaaa gcttttgctc attcacctaa aaagaaaagg actaagatg gtggttgta 12060 tctaacggtg cctatagaa taaaaacaag tagatgaat aaaaacat accagactt 12120 aaggtcttta aaatagaca gttcaagtaa ttcagtatct actcttactg atttattaga 12180 aggtagacga agtaatatta gtcacccatc actaaagcct gctagtaaat caagtagaat 12240 tactaagta agaatgta aaaaatctag ttactttag tttagacag tacttagta 12300 atcccctgca agttcatgga tattaatag agataggtt atgaaaaca acttctctaa 12360 aaacatta aagtagtta gaatcttat gaactgaag attagaatt tatgtaga 12420 aggttatgga agtaggatgg caatacatc agtagactca tattactag agcaataa 12480 gcccagatta catacagtac taagtattg tttattata catgagtttt taaagactt 12540 tgatttacaa actagggaaa tgttcaaga ggctttttgc ggtaagacg actaggcacga 12600 agtaacagta gggttcaattcctagctt taaaaacaac tacgaagctc attackacctaat 12660 acactagga caggtcaag agttaaaaa ctctttaggt agtatacaag gttcttatctct 12720 agaagcttcg gtaacacat atagtgaaca atcagtagct aaagagaag gtaatcgttt 12780 agtatttcat gtatctaaac ctatttctaa tgtaataga gtagagaca tagcgttttga 12840 ttcttacgat gatgttaaag tatcagataa cactgtatct tttatta ctaacaatga 12900 gacttatgaa ggctacaacg caatattgt atatgtagaa aaaacaatg atagtaagg 12960 gttagtaaaa gttattacca tagagaca agtaacatt gtgggtagt cgtataatgt 13020 agatgttgct agatgtttag atgccgtatt aaaaatgata ttgatatcta tgagagacag 13080 tatagagaa caacat tccagctaca aaatcttgca tttggata tcgcacctat 13140 attccaagac ggtgagtcat ctatctttgg tagacctact ataatttaat acacaagttc 13200 attagattta gatatacha tacacaag attactttca agataagg 13260 agcaaaaga taatggcta gaaaacacct aaggtaaaa cctttacagg tttgtacat 13320 atagatacat ttttaaaaac agcacagacc ttgttaata tgaaagagtc acaggtagca 13380 ggttttaaag cctacatgga aggtaacac tacctgttca atgaaaaga ctttattcca 13440 tttttagaaa agtattagg tagagatta gaatttaat atagattag gagattatta 13500 catggcagtt gaaccgttc cacgaagacc tgtcactcgt ccacatgcag tcattaatgt 13560 agacagtaca ggtatcggta aatcagctag ctccagtga aagatttt gtttaattgg 13620 acagctgaa ggtggtaaac ctgataccgt atatgatta agaactacg cacaagctaa 13680 aagactattc cgctcaggtg aattacttga tgcaattgaa ttagcttggg gttctaatcc 13740 acaatacaca gcaggtaaga tttttgctat gcgtgtagag gatgctaaac cagctacagc 13800 tgaagtaggc ggattgaaag ttacttcaca gatttatggt aacgtagcta acaacattca 13860 agtaggatta gaaaaaaata caatcagtaa ttcattacgt ttacatttaa tcttccaaga 13920 tgatagattt aatgaaacat atgataatat tggtaatatc ttcactatca aatataaagg 13980 tagtgaaagt acagctactt tttctgtaga gcacgataaa gagacacaaa aagcaaaaag 14040 attagtatta aaagctaata gcacagaagt taagtcttat gacttaacag gaggagctta 14100 cgctactact aatgccatca ttaacgatat taaccaatta cctgattttg aagctaagtt 14160 atcacctttt ggagataaga acttagagtc ttacttatta gaccctatga cagatgttaa 14220 cattaaggat aaagctgagt atgtaaaagc agtatttggt gatttagaga aacaaacagc 14280 ctataacgga cttgtttcat ttgaacgatt agtatctgaa caagcaccta aaaacgtaga 14340 agtagacgca catgaagaat ctgctactgt aacagctgtg tccccaattc aagaaatcac 14400 accttttgaa ttaacaaaac tttctggcgg tacaaatggt gaaccaccag ctacatgggc 14460 agataaaatt gaaaaatttg cacatgaagg cggatactac atggtacctc tatcatctaa 14520 acaatctgtt catgcagaag tagcttctt tgttaaagaa cgttctgatg caggtgaacc 14580 tatgcgtgct attctaggtg gaggatttaa tgaaacgaaa gaacagttgt ttggtcgtca 14640 atcatcatta tctagcccac gagttgcttt agtagctaac tcaggtatat tcacaatgga 14700 caatggtcgt aagttacatg taccagctta tatggtagct tctgctatcg gaggtttggt 14760 aagtggttta gctataggtg agtctattac ctttaagcaa ctacgtatta ataatgtaga 14820 ccaattatat gaatcattag acttagatga gttaaatgaa aacggtatta tcaccgtaca 14880 atatgttcgt atagagcta atacattctt tagattaaca gacgatgtta cgacatttaa 14940 tgataaaaat gaccctgtta agtcagaaat ggctgttggg gaagcaaatg acttcttatg 15000 ttctgagtta aaacttgagc ttgaaaataa ctttattggt actcgtacta tcaatacaag 15060 tgctcaatt atcaagact ttgtacagtc attcttagga cgcaagaac gagataacga 15120 aattcaagac ttcccacctg aagacgtaca agttattgtc gaggtaatg aagctagaat 15180 ttcaatggtt gtatacccta tcagaagctt cagaaaatt tctgttagct tggtatacca 15240 acaaaaca ttagagcct aaactaggac aaggtacc tagtttaggt actcctatta 15300 aatttaatag gagagtgaat taatatggct tcagaggcta agcagctgt ccatactggt 15360 ataccgtta tgctaatggt aaaaggtaaa ccagttggaa gagcacaatc tgctaaggt 15420 caacgtgaat acggaactac tggtgtatac gaaattgta gtattatgcc acagagcat 15480 gtttacttaa atatgctgg tacaattaca ctagaacgtt tacgtatgaa aaagaaaac 15540 ttcgcagatt taggatatgc ttcactggt gagagattc ttaagaaga tattattgat 15600 atcttagtag tagatactt acgaaaaaaa gttattatt catatcatgg tttattaaa 15660 cagacccctt gtacagtgat gtgcattgaa taatacctta aattgctaga acaccgtaaa 15720 gctaactaaa ctacaagta agtcgaaaga ctaagcttga atgttgagaa atcagaaaaa 15780 attagttaga tggtataagg ttaaatccta agtactacat aattgtaat tagcatccaa 15840 gctcctgtaa atggagaag gttcaacgac tataataggt aagtcttagt tacatataa 15900 gattatggca tagtctagtc ccttaaaata tatcgaaaga taggtataa acggttcagc 15960 aaacaacac aacgagactt ggcagacaa tgaattgta acagaaa tgagtttag 16020 ctacctttaa ctatagagg ctagttttgg tgacaagcat agaaacact ttaaattgcg 16080 tgaaagtctt aaagactaga taactacaaa gtaacctgaa agggtaagct tgaatgttga 16140 gaatcagaa aaatatcta gtatagtata aggttaacc ctaagtacag taaatagat 16200 gatacgcagg caagcctacg agagtgggaa gcttcaacga ctataag tgagtcttag 16260 ttacacatta agatttggt atagtctact ccctttaaaa tatatcgaaa gatggtat 16320 agaggacagc atcagataag gctagaactt aaatttcgta ttaagaccta acataaag 16380 ttaggtcttt ttttatactt gttttag aagtactgta ttattatta aaaayaagg 16440 aggtgtacta atgacaac aggaaaaaaaggtaagt aagtaatca agggcacat 16500 ggaaaattta accacaaaaaaaaaaaaatattct agaaaaaata 16560 agcataagg tattgacaat tataaatac tgtaatacta tagttatata aggagatgat 16620 gaactgtgaa aactttttat tcaggtagaa gaaaacagg taaaaacagg gaactgaa 16680 agcattaata acaatgact aatcaagaaa tattatatg taggaatta ctaaagagg 16740 cttataata aaatattac tttaagttaa caatcactt aaggtaa tgtaagaaac 16800 cagtaaattt taagcgttt gttcattata tacaataata gaacttagat attagaat 16860 atatgaaac attatacaat aaaaaatac aacgtaggt agttgttaga cacccttatg 16920 tagtaaagt aaaataaa ttcttacc attattagt tattagagtt gaacaggtg 16980 aagttgtaac tatgtactat aacagagtca cagatacca caaacatta atttaatg 17040 attattatga taaaaattta aaaaaagt attgacataa gtaaatacat attatatact 17100 aaggttacat taataaagag gagaataaaa aatgacaaat aaattaagag ctatccatga 17160 agaaatgaaa attgagttac ataaattccc acagaatgta gatttaacaa gtaagacaac 17220 tgctattgca atcaatcaaa ttcttgacaa gtttaaaacc ttaacggaac aagcaggtaa 17280 aatcactaaa aagtatttg agggtcaaga gattttgacg attgattttg aatattatga 17340 ctcacttcaa gattactaca tttacttact taaaaatagt gaaacaattg aacaaaggtt 17400 acaagaaatt gaaaaaagag tagctgaata tgttaagtaa tttggagtta taaccacatt 17460 atgttatact gtatgtgtat aaaaaacata agttagctgt tatattaatt atgagaaaat 17520 aataaaggat ggataaagaa ttggaaaaag aacaaaaaga tattaaagat atgacacctg 17580 aagaaattga tgaattaaaa tatcagcaac aaaaagataa agagcgtgtt attaacaaag 17640 taattaaagg tgttaatgat gtatgggaga aagaatacaa ctttgaagaa ttagatttaa 17700 aattcaaagt aaaaattaga ttacctaatg ctagagaaca aggtaatatc atggctttac 17760 gttctgcata cttaggtgga atggatgctt atcaatctga ccaagttatt aatgcttatc 17820 agatgttagc tactctacaa gaagtagggg tagaagtacc taaagaattt agagaccctg 17880 aagagattta taacctaact ccacttgcta ttatgtggga tgattggtta gactttatga 17940 cgtcctttcg ttactagtaa cgtaaagaag ttaaatgaag atatagaacg gttaggtgga 18000 ctttcacata tagctagaga gcctttatca agaaacttat gggctatcat gcgtgagttt 18060 aatgtgctac ctaccgaaca acgttttaaa gatttagatg actatcaaat agagtttatt 18120 atagctaaca tgaatttaga tacaaaagaa atgatggaag ctagagacgg taaaaactat 18180 gatatgaaag cggagaacgt agacacatca tggttcgaag cgccgacaga tgaatttgat 18240 gttgttcctg atttcttaga cttagatgat ttaaatacac aagtagataa aagtttaagt 18300 gagaaagaaa agatagaaag agatagacga gttgaagctg agttagaaga tgaaaccgag 18360 ggattaacaa ctcaacattt agctatgatg gaacacataa gacaaaaaca aaaagagctt 18420 gatgaaagtt taggtattga taacaaagaa acaacacaag aagatataaa caaagcaata 18480 gagatgtag atgattgta catgtagggt aatgtataa caccaatacc cttatttttt 18540 gattaggtgg tgaatactgt tggcaatga atgacgatta taggttggtc tgactggtg 18600 atagttctag cttagacaaagtttaaag ctatagagat gtacatggat gcgttagagt 18660 ctaaaaacat agatgcacca ttacaaact tcttagagaa atttaaagta atagcaaag 18720 aagtaaaatc tgtacaaac attggata aaaaagtga tagtcttta atcaccaa 18780 aagctatgga tgaggtatt agttctacac agatgtaac windowata aacgaccta 18840 agaaagcttt aaatgacata siacata atattacaa gggtatagct cctgaccctg 18900 aagtagagaa agtatagt aaacttaata agacactaa tatacaca agaactag 18960 agaaagtagc atctcaaag attggttcag actcagatat aaaaaagaa 19020 tgaaaacact gaaccaagtt acagagagt ataataatt agtaaagat gccagttcag 19080 ctaaggagta caaagcaa ctagagcta atcgtaat ggttagaggt catatatcta 19140 ggtctgaagg ctctaataga atgtcctatg accaaggtgc tagatacgt tctgaattag 19200 gtaagtaga cactttgaa aaagcaacgag aagctaacha tagaata aaaaaacc 19260 aagatagata taggttat agacaac aaagattt agtaggcaa agagctcgtg 19320 gtgaaataag ttctgaggt tataaaaaac aatcagctc tattaaaatg atgattgatg 19380 aaagtgaaaa gctttctgaa gtttatagaa aacaggtgc tgaattagac aagtcaatca 19440 actacttaa aaatagtgct aaaaaacagt ttgctcagcg tgagatagaa cagcaacgag 19500 gaacaatggg taaattgttc caagatagat taccatctat tggtgcacat gctactatgg 19560 cagtaactgc tcttgcaggt gtatgtata tgaaaggtgc ctccttatcc gaggcaata 19620 gacctatggt aacatcatta ggacaaatt cagaatatat ggatatagac gcagtaagaa 19680 atacatatgg agatttgtca atacataata agcttggtta taattcact gacatgctaa 19740 aaatggctac gtcatatgaa agttctatag gataaaag cgatgcagat acgtataag 19800 gagctaaca gttagctgta ggtggtcgtt cattaggtat acagaccaa gaagcttatc 19860 agcaatccat gtcacaactt atgcatacag gtggcgtaaa ctcagataat atgaaagcta 19920 tgcaagatgc tttcttaggt ggtatacgtg aatctgatat ggttggtaga caagacgagc 19980 aattaagagc tttaagtact attgccgagc agtcaggaca aggtagaaca ttatctaaag 20040 gagaaatgtc taatcttact tctctacaag ctcaagtagc gggtacaggt agtaaaggtc 20100 tacaaggtgc acaaggagct caagccttaa gtagtattga ccaaggtatt aaaaatggta 20160 tgggtaattc ttatactaga ttagcaatgg gatggggtac taagtaccaa ggattagaag 20220 gtatgcatga cttacaagca caaatggata aaggtatatc agaccctaat aacttagtta 20280 atatatttga ccaagctaat atataggaa gtacaacaaa agaaaaacaa gccatagcta 20340 aaaaaggctt tgaaagcatg ggagctaact taacacaaga gcaaacagat gagttgtaca 20400 atctttacgc ctcaggtaaa ctatctaaag aagagttagc tagtaaagct aagagcatgg 20460 aacaagaagg ctctaaagca ggagataaaa ataaggataa gtattccgag tctaaagcag 20520 gtagaaatga ccataacaaa gctaagacag atgataaagc tgaggatatt tatgacttag 20580 ctcaacctat tagagatgtt catagtgcta tggcaagctt gccagctcct ttatacctag 20640 cttcaggagc agtacttgcc tttgtagcat ctttagctaa atctactgcc atgatggctg 20700 gtggttcttt attaggtaaa ggtcaaaaag gactaaaaga ttggtttaat aaccgtaaag 20760 gaggttcaac aggtaagact ggtggtagta aacctggtgg taatcctaac ggtggtggac 20820 gctttggagg acttaaaaac ttagctgaca ctatactagg tgataaccct agaggtggag 20880 accgaccatt taagaccaa gcaaaaggag caggacaaac tgctaaaggc atgggtaaaa 20940 ccttgtttga tacctttgga aaaagagatt ttactttttgg tgaatatatg ggaagaacca 21000 aagacctagg taaaggtgca tggaacaaag gtaagggagc ttttggtaaa gctaaaggta 21060 aatttagcgg taaaggttct gacttaggtt tttgtcaca agcacctact gctaacgcag 21120 gaggtcttgg taaactaggt ggtcttacaa gtaagctagg ttggattggt gcaggtctat 21180 cggcgtttga tataggtagt tctttaatac aaggagatac taaagaagct tcttctaaat 21240 ttggtaatac tataggaagt attatagacc cgttaaattt aggctatgga gatggcttaa 21300 gagattatgc tacgaaaaca gcggaaggtt ctatgacaag tgatggttgg aaattatggt 21360 ctaatggaga taaagatggt aagaataaat tccaagactc tcctgtaggt aaactatggg 21420 gtggcataac agatttcttc acaccagata acccttctaa attagacgag acagtgaaaa 21480 ataaaaaagg taacataatt agttatatac taattgcctt gcttatagag caatctgtaa 21540 gtaccgagtg ttaactgcta tgaaactact aaagctaact aaactacaaa gtaacctgaa 21600 agggtaagct tgaatgttga gaaatcagaa aaaattagtt agatactcta aggttaaatc 21660 ctaaggagaa gtacaatggg tgtatagcat cgaaagtcct aaagacctga aaggtctacg 21720 gaacacgttc aacgactatt ccgtataggt gacggaagta aagccacaag tgattggtgg 21780 aagaaaaata ctcaccctat actaataggg ataacaaata gtctgcgcac gtaccgaaag 21840 gtagtgtcta gaataacta gagaatatac agtagcgtgt atatttaaac attgttaaaa 21900 tatataaata attaaaattt gtattctact tctgcatata aacctttctt attttgtaag 21960 gtaaacttgt tattaata atacataa ctaatacgat aggttatata tgaaagtata 22020 ctattgttta tatgttttaa cttatggtat tatgataa tcacaagta aagacaggca 22080 aaaaaaaaaaaaaaaaaaaaaaaghaa tgattcaga gaaaaaaaaaaaaaaaaaaacaetta 22140 ctcacatttc ttagaccatt tagcagataa cctaacaat aaagtagta gttctaacga 22200 cagttcatca ggaggacac ttgactacct tgatgtaaa aactttacgg ataagacgt 22260 aactaagcat gacttaggta aactgctaa aggtgtaac gccgaatgt taaataatg 22320 gattgagtct caagcaccta gtaattctaa atgcgcggt ttaggtgagc tttatatgaa 22380 agcaggtaaa gagtcaggac ttgaccaag gtatttagta gcacatagtg ctgttgagac 22440 aggctgggga acatcaaatc ttccaagg aggaccct aacaaaggta actggttcgg 22500 tataggtgct tttgataca atcctaataa tggttttaac tatggttgg gtattgttgg 22560 tggtgctaaa tggattagag acaacttcta siaaaaaaaaact tacacgaat 22620 gagacacaac aatggtgttc atgaatatgc aacagcaggt aattgggata ctatgattgc 22680 cagtattatg aaaggttcag acaagttcat aggtggcgga ggtggaggca gtgatgttat 22740 gcctagacat gctctaaaaa acgaccatca accaaagaat cttaaatata acatagaagt 22800 acctaaaagt aaaaacccta atgaaacagg gaaagcaata ggtagaaaat taaaacaatt 22860 attagaatct aatttttaga atacaattat aatacttata tattttaaca aatggtataa 22920 ataataaaaa acagaaaatg tctacagaac aactaagaga aaagaataat aaatcagaaa 22980 ctaaaaactt aaaaacttac agtaacctat tagatagagc acaacaaatt atagaagatg 23040 ctaaagcgct agactcagga ggttcagaca gtagttctga ctcagggggt tcagcttccg 23100 atgtagatgg agaaggtgcg ggtaagattt acaaattcct taaaggtaaa ggtttatccg 23160 ataaccaagt aggtgccgtt atgggtaacc ttaagcaaga atcagggctt gaccctaatg 23220 caaagaacgc ctctagtggt gcttttggca ttgcacaatg gttaggtagt aggaaatcag 23280 accttgatag ctttgctaaa tctaaaggta agaagtctaa tgacttagac gcacagttag 23340 atttcttatg gaagaatg agttctggtc aaatagtga tatgcttaa atgcaggat 23400 ggagtaaag tggtagtttta gaaaaaaata caaagcttt tgcacaaggt ttgagcgta 23460 tggtgctgg agaggctatg atgagtactc gagtaataa cgctaaagt tatgtaagca 23520 atacggtaa gtcaggtggc ggtggcggtg gagctatacc atcatcatat acgtccgtat 23580 taagaaaccc gatacttagt agtgctcag gaagtactgc atctcaaat aatgtatctg 23640 tgaatgttag cattacagga acaatgaca aaaggtgc tgagaata ggtaaggca 23700 ttaagtctac ttttggagat gacttagata ttttctcaa cacatataaa cgtaattact 23760 agggtagtat tattagtac taccctttat aaaaaaa aggagtaca agtagtata 23820 gattagacg tcctaagata cgattagaaa tagtacaga tgattaca tttacattaa 23880 agtttgaaga tactaagat tacaacggca atcaatttgc ttcaagtta cttagttttc 23940 aaactaagaa tgctatggaa gatgagtg ctgtattcca ataactatg gcaggggata 24000 cgtattggga taagctagta atggcaatg atattattaa gatatatat acgcctaata 24060 atgaccataa agataagag ggaaccaag agaacttat acagtaggt atggtatctc 24120 aagtatctaa agtaggtagt tatggtaatg accaagtaca atttagaata acaggtcaat 24180 cattgtaaa accttttg aagttttggtt taggtgtta tcaagaggta caagctgtat 24240 taccaactgt tggttgtta gttgatggcg atggagaa tcaggttaa tttacaggta 24300 gttccgctaa agatgtaatg caagttatta tacaacgat tattccttac atgagtaca 24360 attacgga acaactac aacattag agagttactt nagattat gattactcta 24420 gttgggatga gtatgaaag tttactgaag ttccgcttt tactacttc gatggtacat 24480 taaaacaact tatggactta gtaactgcta gaccttttaa tgagttattc tttagaaatt 24540 cagataaca taaagtaa gcacagctag tattagaaaactcctttt aatccaactg 24600 aatggaaagc actagaatac atagttgtac caacgatga ttttagag gaggatgtag 24660 gtaagagtga tgtagaaacc tacttactt ttacagtaaa accagcaggt atgttaaaag 24720 aattaacagg ggatgtattc tctaaacctc aatttcacca agaattagta gatagatacg 24780 ggtattctaa atatgaaaca gaaaacctat acataggaac taagagtggt agtgctacag 24840 aagatagtga aactacaggt ggagataacg gtcatgaacg agtaacttat gacagactac 24900 ttaaagattt aaataactat ggtagagagt ccatatctaa aggattagat aaatactcta 24960 gtaagatatc atcaaagtac aacaatatta ctaaaacctga agtaaagagt attttagagt 25020 cttacataa aaaaggtaat ttaagtaaag aagattatga aaagataaca aagaataata 25080 cttcaagaga atcagtatct gatactagac caaagttaac aaaagaaaaa ttaaagtcta 25140 tattagcgga aaagtttaat aaaaaagaaa cttttgatga taaagattta aataagaaaa 25200 caacaaaagc tgtaatagat gatattacaa agaattataa atatggtaat cctgcacatg 25260 ctaagaaact actagaggat tacactagat ttaaaggcaa cccacctaca agtaccacag 25320 gtgatattta tgataagtat cttaaagccg tagaaggagt agctaatgtt gctagagata 25380 caggttctga cgcaagtgat gaccctttaa ttatatttac taaaatgcta tttaattggt 25440 atcactcaaa ccctaatttt tatgcaggta atattgttgt attaggtgac cctaagtatg 25500 acctaggtaa acggttattt ataaaagata aacaacgagg ggatatatgg gagttttaca 25560 tagagtccat agaacataag tttgattata aacaaggata ctttactaca ataggagtaa 25620 caagaggact aaaagatgct attataaaag atggtgaagg aagcaaacat aggtttaaag 25680 gactatggaa tcagtcatct gactttatgg gtggtcttat gggtgaagag acatctaaag 25740 attaaaaga aaaaggtgta gccgagaaga aaacaaaagg aaataaagat ggagattctg 25800 acggaggcgc acaagatgga ggtaccttag cttcactaga aaaatataat ggtaagttgc 25860 ctaaacacga cccaaatttt gttcaaccag gaaacaggca ttacaaatat caatgtacat 25920 ggtatgctta tatagacgt ggtgagttag gtattcctgt tccgttatgg ggagacgcgg 25980 cggattggat tggcggtgct aaaagtgctg gttatagtgt aggtagaaca cctaaacaag 26040 gagcttgtgt tatatggcag agaggcgctc ctggcggaag ccctcagtat ggacatgttg 26100 cttttgtaga aaagtatta gacggtggcg ctagtatatt tatatcagaa catattatg 26160 siactcctaa tggctatggt acagaacaa tagacatgag ttcagcaata ggtaaggtg 26220 ctcaatttat atatgataaa ggatattga tatggcaacg gataaacag ttaagatgt 26280 tatagataaa tttatagata atctttcaa ttttgaagta ttaaccaag aaaggttga 26340 agaaaagat agagagtta aaagataac tacagac gtatacata aagttgtttta 26400 tattagacca tatgtaggtg tattacaag tattacacct agacaggtaa catatgatag 26460 ttttactaat aatggtacag atatagaagc taaactcaca tttagaaaaa taagttatac 26520 tacagataat ctcacagtac ctactgatgc atatcaact tgtatggtgc atatggtaga 26580 aagaaatggt gtacttgtta tagattactt tgatgagtta cagaacatac tgtactgtag 26640 ctacatggag atgagcata tattgatga agatgttcca gttagtacat tagtacatt 26700 agacttgaaa gagaatttaa atattaa acatataca atatgtttta aaggaatac 26760 ggataaaaat ccttttgaaa gtaggatat agtaccttta gatacataca acttattata 26820 ttggatgtat aaaaagagaa atgtagagct aaaaaatcca ttacagtta actactctt 26880 cacaggtaaa agcttctata ccatatttgg taaggacac aaatataaag ttggtattga 26940 caattcaa taggta tactattctt ttggt tagtata tag 27000 catgggagat aagaagttta ttctcttat gggtacattt cctaagata acacctctat 27060 tagtacctat gagttagacg attattggga tgactttaat ggtaggtta tgaggtttga 27120 tgaggatgat agcatggt aggatta caatctctt taggtagag tttaaaaag 27180 atagactcag aagaacttaa tgttaaaggt ctattattag gtacagtag CAAAATAT 27240 tataagtacc aactgtaga agttaaata atagtttta cattaggaca taaccctagt 27300 gatgatgta agttagctgt tccttatcct aagattatg taggagaac acctgaaggt 27360 agtatgtag gcagtaatac tttaatacg gaaggaacta ctgtactgtt aggatttatt 27420 aatgatgaca tattaccc tattatacta gctactacg gtaatacaga agcaaaccaa 27480 ctcataaata cgaatcctttt aagggtggt aaatgagta atgatgatgt ttataatat 27540 agtagtgctt tgtattctat attacctgac ctaactata catataaga tggtgaaggt 27600 acatctataa aacattca tgtaaatct ttcttatcca ttactcagg tgataagaa 27660 aaacctttat cttcagactt ttatacaggt actgaatacc agacttatt cccatcatac 27720 tatagtaca aaatttaat agaacctaga atacaaagg cacctacat gttattaaa 27780 caccagggtc tatactttga tgatggttct gaagataatc atgttacaac tttattt 27840 tccgaaaag gtgatgtaag agctccgta tagacaaaa gcacacaaaaaacaaca 27900 CAagagatgt ctcatgatgg ttcttataga gttataaagc aagatgatga cctattatta 27960 gactcagcgc aagtatgggt agagttttggt aataatgata ataatgtgtt tatataaaa 28020 aaccctaagc attgtttga atttaatgat aaggtatat atttagatg taagccaatt 28080 ttagatacgt tagatgctag cattaccgag tctatagata ggctttagga agtacagaaa 28140 gattagagg acattaacta cttacttgag ggtgtagta aggaaactt agaggagtta 28200 atccaagaga ctaaaaaatc tatagaagtt tctagtaag caagtagtga tgttacgact 28260 atgaaatctc aaatatctaa tgtagtagt agagctgagg gcattattac acagtttca 28320 gagtttagag aaaacatt taaggctta tatgagatg cttctactat gataataaa 28380 tacaccaag aaatacctga gttaaaaagc agattgaata ctctaggtac attackacatta 28440 cctaacatta ataatacctt attagagaaa tcaagtaaga cctatgttaa taatagttct 28500 haaagtgtta gtagtatta tctaggttca ttactgcaat tagatagta ccttactatt 28560 tatccgtaca cacctacacg tattatatgg aagatag ttttaataa ttctgagtttt 28620 gtaataaga ctaaggatgc tttgttatt ccgttaggtg tatctaaagt taaagttctct 28680 attaatctta atgggaat attachagat aaagtaaaa ctattgcagt attachagat 28740 agtatacat aaacat aaccaatggt atacacacg atatatat tacaatgtt 28800 atacctgtta aaaaggaga tacattcaca gtagaagtac aaagata tgatattaac 28860 cttacattac tacagata tacaatgttt agtatagaag tattagaac tactttagca 28920 cctactaaca ctgagttatt aggtacagta tccgaacaaa cagataagca actacaaca 28980 cttgtaaatt ctaatgttga tttattgagt ttgacacac aagttactaa agataatcag 29040 ttagtctgtc ttaatgattc taattagat actataaca caggtaagg tatgtgtct 29100 gattacactc tacacaaat aaagtcattt tctctaaga gtggagaag tattttact 29160 ttagagag tattaacta ataaaaat tctgttagat acagtattaa tttaccaact 29220 actgcaaaca tagtagaact actgaaaaaa tataattta ttggtataag agcacctagg 29280 aatcaagtgt atttgaaagt taagattta acaatcacac aagaatatt aaatatttt 29340 tctaacttac cagtattata taatacttcc tatctaca gtacagatat tacaaaggt 29400 atatataca atatatacgg agtacta ccatatacta gcatcactca agatacagta 29460 atacagcac ataataata cctatctata tatgctagtg gtgatatgac aagtgatatt 29520 aataatagc tttatttata tggtatagat ggtgtagaaa CAAAAAAT attagagtttt 29580 aaaaagttt aaagtccta ttaatagggc ttttatat atgtcatgtt atattaact 29640 tgagaaagta gttgtattta attcctatat atgatataat acgatataga aaggtggtaa 29700 gttatgccctc atcagatgg aagaataca atagacgta ttgcattacg tttccaaca 29760 gcaagcggta atatata gtaccgttttc aaagtaacc ctgaagtta tgaatagat 29820 gcaccacaaa gaacatctat aactaaaact aaatcagaca ttattgttga agactacggt 29880 aaagatatag agacaataac ttttctgt actactggat ttagacctgt aaagagta 29940 gatggtacta aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaacaat 30000 gctaagcagg gtggagatgg tagcgtagca ggagcttata taactttact 30060 gatgataaat attacaagt acatctagca ccgcaaggtt taaaataac aaggtctaaa 30120 gatgaatcct tgttatatag atatgaaata actttagttg tgataggtaa ccttgctgaa 30180 gcagatagag gttccgtaac atctgctgag ttgtaatg taaaacctaa tgctaaacaa 30240 agagttgatg agggtgttaa tgatttagat agtaacgcac gaaaaacaag aaaaaaaat 30300 aatcaatag tatcacaatt tgaaaataa agcagtcaa gctctctaa ttctagtagt 30360 agcggttcac gatatggac ggcaggaca ttagaggg gtagtggcat aagaacaggt 30420 ggttctgagg gtatagaga cggtagagt atataggta tatataaccc tagacagaat 30480 actaacggtc ttagtagtac tgttgatgat atggcactta aaataggata cggtgatgga 30540 ggtgtatcta ggtaatgaat attatatac ctcaccaca aggactatta aggtttta 30600 attagattaga gttagacatg tcttacacac attagaactt attagatgag gaagtacctt 30660 ttgttttctaa attctataca ccacaatac aactaagtga acttgcaaga aaaattaa 30720 aagagatta gtctactgat atccctactt tagagaac atttacaac atacaatag 30780 tttaaagt agaaaca agtttaagt tacaatcacc tegatgtat ttatttgc 30840 aatctatcgt aatggaagct tacgctattg taaactgctt tgtagaagt cctgaatact 30900 taaaatatttt aagaaaaa gatgtacta tagtagaag taatgttac tacgtagctg 30960 actacttaag tgatttagaa gatatacaata gtattgttct cgatttaaga gacttagact 31020 tatgttttgg ctctttggaa ttacactac cactattaa gagtgaggtg gtataatgag 31080 atttagaaag catgagtcc aaccagaaga aaccttaca gctatatcac aaagtatta 31140 tggtgatgtt agttactggt tagattaat agacataac aacttacaat atccttatat 31200 tgtagataca gatgagaaa agaaaaagaa ccccgagcat ttaataacta aaggtgatat 31260 tattatta cctttagatg ctgagttaac agactcggtt tctaagaaa taacatcaag 31320 agaxaagat gtattagtag aattagcttt aggtagagac ctaaataatga cggatataa 31380 agagtatata gacgctcatg gaacagatga tgaaatatta gccctatctt cagatggtag 31440 aggacctt gatatagtta aaggcataga tatattag caatctttaa gagctagact 31500 attgacacct aaggttctt tattaca tcctgaatt ggttctaca ttcataattt 31560 atttggttta atataccctg aacaagctac gttaattgaa gtagatgtat taagactct 31620 aacatcagat agtagagtta atcatctaa cttaaaaggt tgggataa agtaatga 31680 atactatggg tcatttaatg tagaatca gtccgtagaa gatctatag actttgtatt 31740 aggtcagat gattcaggtg tctttgcttt atttgactaa gaaggaat ttatatgaga 31800 acaagaagt acacagat attatctagg ttaatggata agacgataca aggtacaagc 31860 aaaaaycag actttacacc tggttcagct gtacgctctc ttttagaagc agtagcttta 31920 gaatagaac agtattatta attack gaaacatta attggggcat tcaagaaggg 31980 attattgaag cttttgattt tcaaaaaga aaagctaagc gtgcttatgg taatgtaac 32040 attcaattt accaacttt agacatgaga atgtatatac ctgcaggtac tacattctca 32100 tctactaggc agaataccc tcacaattt gaacactag tgattacta tgctgagaa 32160 ggaaccactg aaattacagt agaagtttat tgtaagaag ttggtattgt aggtatata 32220 cctgaagata tcattaatac atagcctca ggctctagtt tagttcgtac aattacaac 32280 ccgactcct ttatacagg aaaaaagaa gatctcaag aggatttta acgtaggttc 32340 catatgtttg tagatcgag aggaaggct actaataat ctattagata tggtacatta 32400 caagtacctg atgttgatgg tgtttatgtt tatgagaag taggtcatgt tactgtatat 32460 gcgcatgata aaaacggaaa tttatctgct actctaaaa atgacataat aacggcatta 32520 gagattaca gacctagtgg tataaaatta gatgttgtag gcgtagagaa agaggaata 32580 gatgtgtctg cagtagtac attackctaat aaagctagg taggtgacac attack 32640 catattgaaa gtgttattag agggtatcta atagtttga ctacttctga tgactttatt 32700 attack tattcaagc tattgaat atgatgata atttaattta tgatgtagca 32760 tttagaatt tattacaaa tagata tctcgaaag gttattag agcaggagat 32820 attaggtag aattaata gggggtaaac atggctaat ttttagaa acttacaccc 32880 tttattaaga agaaataga attaataag taaccagac cctaactag ctttaataac 32940 agcacttaat gatgagatga acaataga gttagacacc atttaaagca aacttcaatc 33000 atcattaaaa actgccacag gagattactt agatagtttt ggggattggt ttggtgtata 33060 springgaata atgagaatg springing springgaaaaga attaaaat acttattatt 33120 gaaaagaggt actaataatg ctacattag tgctattaaa gactacttag atatgagaa 33180 tataaatgtt agtgtatatg aaccttttaa aatatattc tataccaata atcaaatt 33240 aaatggtgaa gattatttaa tgggttatta ttatagattt gctgtgataa atgttttctgt 33300 tgatggctac tttcctttag agattataga tgtaataaat gatttaac ccgcaggtgt 33360 taagttatat ttaacttatg atggtgctac taccataag ggtgatggtg ttgttaaatg 33420 gcttaaaaat ctacctaaga ttgaacata taggttatta gatgattat taggttatga 33480 tgaaactttc tatggacatt tgaacatggg tgaagcaca gctgaacaat ctgataaaac 33540 aaggttcaga acaataga gtacattaaa tagtgagat attctatcag gctcttctaa 33600 tattggacgt agatttataa attatgctta tgttacgaca tattgcatatg aacctactag 33660 tacatcagcc gtcacacata tagcttttt aaatgataaa ggaaagac cacctttaga 33720 tattactta tatacatcct windowatac tatgatata atatattaca tggaaacttc 33780 ttacggtgta tcttatttat acaataactt taatgtaggg gagtttacca gtagataca 33840 acctaatata gatataacta gagataatgc taaaaaaaaaaatccgatt ttgtagggga 33900 actaacaat gatttctttg caaagctt agtttcacct gatgaatcat tacctatta 33960 gttacaaata ttgattttc gtactaatga atggttaact gtatcagaaa cagaactatc 34020 tttttacgag aaaaacatag gtgtaaacat aggttatata agagattact taatgatga 34080 ccttaattta ttcacagat tagaggttaa ttagttaa gatgagcaa agatataag 34140 tattaactac atggattac atttttatta tattaaaaa gatgtgtata ctatcaacc 34200 ttttaaggca ctagttgaaa actacataga tttgactaa gatacttata ttgaaggctt 34260 taaagtagcc tcattattaa atggacat aattaataa aatggatacc aacccataa 34320 attttaagg ttacatgcta cttatgattc aactaaacct attgtaagta ttacaggtaa 34380 aaacagcaat atgaggtac aaaataatac acctatagat ttattaaaa atgcaactaa 34440 tagaactta ttgcaatcat aaaggtga tagtagtata ttcaggatg ttgtaagcac 34500 aaagagttt tatactcat catgggctga caccttatat aactcaacgt atttatctaa 34560 agtactgaa ccacaaaat tatatacttt gtcattcgag atggaatca cagatgctaa 34620 tatggactta aaaacatatt ctgacaatca tgtatatat ttatatagta gtactaagg 34680 tattgttgct aatgtgtta aaagcatgca aaagata ggtaataa ttgatgtatc 34740 taccacattt acagcaccta cattacaga ccatagactt gttgtttaca caggtagata 34800 tacagcagat ggtactgcct ctaaaaacacc tattgcttct atacggtaa aagtaacaa 34860 ccttcaacta aagaaggag ctactaagaa ggactacacg gtagcacctg aagatgtaac 34920 taatgttata ghaaagcta ttgtgtttga windowacatatta acagatatac aaacaatagg 34980 aaaataca acacaccctc taggaatat tgagctagt tattcttact atgggataa 35040 ttggaaaaaaaaaaaaaaaaaagtaattt aagtcaaggt gaaaaaaaaaaaaaaaaa 35100 cctagtagat ttatatggct tagaacaat agattattca agtattacac ctttctctag 35160 ggttatactt aaactatat ggaatgctaa cctgaataat ttaacaata aaaaggtag 35220 tattctaac atgagtaata actatttca tgctgtgtgg caagaggtag attgatata 35280 blind tagtag tagtagt tacttag tagtag ttttgag 35340 ttcacagga caggtaata attackacc windows caggatata ctgatgtaga 35400 tagattgcta acgtctacta ctctata cgagaatatt acattaggtt caatagatt 35460 tatttatgac ttacggata tgttactatc aagtgataca ttcacagtag atataaaat 35520 taaagtata gatataca cagaagtaca gtaagatat tgacataaa gttattaat 35580 gatatagtaa ggtatgcgta ttatagtata ccttgttata ttaatacaga atactagaca 35640 tgaaaggaat aaaaataatg gctatagcaa caatgctc acatgtagaa ttagctaat 35700 acatgtaag taaggctgac tctattt taacaatttgg taaagtaca gcgtggtcta 35760 atgaacaag tccacctcaa cctgagaaa cagcaacatc attack gttatcggat 35820 aaaaaagc aaaaaggta gcattagtta gacctgcaa aaaaaaggt gatgaaata 35880 aaaaagaat tacatatggt aaaacgat gggtagaat tgattcagct atgcagttg 35940 ctgaaggtgc taagtgggtg tacttagaaa gtagtattgt tgggatga ttacccttag 36000 gtacatatag acagtagga ttgttatgg atttgttagc tAAagataat atttctaaat 36060 ttaacttact acctagtgaa gtgcaatcta caggaacctt attattat gataataac 36120 aattccaaaa taggtgaaaaactg taaaagagcg ctttatcatt gagtttaa 36180 aaggagaatt gatatatat ggcaattat tttaaagtt ctccatactt agatagattt 36240 gaccctacaa agatagaac agagtacta tttaatccag atagaccact acaacca 36300 gaactaaatg aaatgcagtc tattgaacaa tattactta aaatttagg ggattctatt 36360 tttaagatg gagaataaca atcaggatta ggttttacat taactaaga tatgtacta 36420 caagttaatc caggttatgt gtataaat ggtaagatac gttactatag tagtgaagac actgttaaga ttacgggtgt aggtaaaga acagtaggta ttaactaac agaagaatt attacacctg atgaagatag tagcttatta gaccaacaa gcggagttcc tagttatttt tctaagggtg cagaccgttt agaagagaag ttatttttaa cagtcaatga ccctacttct gctactattt atacttttat ggatggagac ctctatatcc aatctactaa tgctgagatg gataaaatca acaaagtatt agcagagcgt acttatgatg agtcgggctc atataaagtt agtggatttg agctattttc agaaggaac gccgaagatg ataatcatgt atctgttgtt gtagatgctg gtaaggcata tgtaaaaggt tataagtag ataaaccagt ttctaccaga attagtgtag agaagtcaag ggaattaggt aaagcagaga atgaaagtac tgtatttaat aaatcatcaa father tttagctaat acccctgtaa aagatgttca acgtgtaaca gcacaagtat character agagcgtgtt acaagaagtt caacaggaga ttctcaagac 37140. tatttatcta ataaaacagc ttttgaagta gttagagtat ggacagaaac aagtccaggt cagacaacaa aagaatacaa acaaggagaa gactatagac ttaccgatgg tcaaacaata 37200 gactggtctc cttcaggtca agaacctaat ggaggtacat cttattatgt ttcgtataag 37260 tacaatagaa agatggaagt aggtaaagac tatgaagtat ctacagtagg tgagggagta 37320 ggtaaacgtt ggtctattaa tttcacacct gttaatggta ctaagcctat tgaccaaagt 37380 gttgtacttg tagactatac ttactactta gctcgtaaag atgctgtttt tattaataag 37440 tttggtgaca ttgctattct taaaggtgaa cctaatatta tgagattagt aacaccacct 37500 ttaaatacag accctgagaa cttacaatta ggtactgtaa cagtattacc tgattctaac 37560 gaagcagtat gtatttcata tgctattact agattatcta tggaagactt acaaaaagta 37620 aaaactagag tagataattt agagtataat caagctgtta atgctttgga tgatggcgca 37680 atggaaaaac aaaacccatt aacattacgt tctgtattta gtgaaggttt tatatcttta 37740 gataaagccg acattacaca ccctgacttt ggtattgtat ttagttttga tgatgcggag 37800 gctactttag cctataagga agctgtgaac aacctaga ttcagg agacactaca 37860 gctcatgtat ggggtcgatt aatttctgct ccatttacag aagacgtac aatttacca 37920 gggcaagcat cagaaacctt aaatgtaaac ccatacaaca taccaaataa acaaggtgta 37980 ttaaaattaa ctcctagtga agatactgg atagatactc aaaatgtaac atcacagaa 38040 cagaaaacta aaaagtaac aatgaaaga ttctggagac atatgaaag ttattatgga 38100 gaacagaac attacttata ttctaactta cagttagata aaggacaga gtggaaggt 38160 aagtcatacg catatgatag agaacatggt agaacaggta ctctattaga ggctggagga 38220 cagcgtacac ttgaagaat gattgaattt attcgtgttc gtgacgtatc tttcgaagtt 38280 aatggtttaa atcctaatga taataatttg tatatttta ttgatgtgt tcgttgtgct 38340 attacaccag cacaggtta tangaaggt tctgagatg gtacaattat gtctgatgct 38400 aaaggcacag ctaaaggtac atttacaatt ccagcaggta ttcgttgcgg tatagagaa 38460 gtaacattga aaatgctaa ctctacaagt gctacacat atacagctca aggacgtaag 38520 aagactgtac aagatgttat tatcaaaaca cgtgttacag taaacttagt agacccatta 38580 gcacaatcat tccagtatga tgaaagtaga actattagtt ctttaggttt atactttgct 38640 agtaaaggag ataagtctag taatgtaact gtacaaattc gtggtatggg agatacaggt 38700 taccctaaca agacggtata cgctgaaaca gtaatcaact cagatgatat taaagtatct 38760 aataatgcta gtgctgaaac tagagtatac tttgatgacc ctatgatggc tgaagcaggt 38820 aaagagtatg ctattgtcat tattacagaa aatagtgatt atactatgtg ggtcggaaca 38880 agaacaaaac ctaagattga taaacctaat gaagttatta gtggtaatcc atatgtacaa 38940 ggcgttctat ttagttcatc taacgctagt acttggactc cacaccaaaa ttcagattta 39000 aaatttggtg tatatacttc taagtttaat gaaacagcta caattgaatt tgaacctatt 39060 aagaatgtat cagcggatag attagtttta atgtctacgt acttaactcc tgaaagaaca 39120 ggatgtactt gggaaattaa aatgatttta gatgacatgg ctacatctac tacatttgac 39180 caattaaaat gggaacctat tggtaactac caagatttag aggtattagg tttagctaaa 39240 caagttaaat taaaagctac atttgagtct aataaatata tttcaccttt attaagttct 39300 aatgacttaa cgtttactac attcttaact gagttaaaag gttcctatat cggtagagct 39360 attgatatga cagaagctcc atataacaca ataagattta gttatgaagc attcttacct 39420 aagggcacta atgttatcc taaatattca gacgatgatg gtaaaacttg gaaaacattt 39480 actaagtctg ctcaagtagt taaggctaat agaacttta atagatatgt tattgatgag 39540 aaagtaaacc aatctactaa gaataacaaa ttacaagtaa gattagactt atcaactgaa 39600 aatagtttct taagacctcg tgtacgtaga cttatggtta caacaagaga tgagtaagtt 39660 taaagagggt ttcataccct ctttttatt aactaaggaa gtgatattat gcctacagaa 39720 tatagagacc cttactcaca agctaaactc tttattccta ctgtagaaga aaaagctata 39780 aaagaaatgg aacaaacata taaagataaa ctacaagaag ttaatgagct tattgatgag 39840 cttaaaaaat tgaaaggtga ttacacacat gacgtttaac tacacacctc taacagaatc 39900 aaagatta aagatagt accctaagt aaatgaatg ggtaaatact taaaagaga 39960 agttaactta tctgatttaa aaacgattag ttatcctgac ttaataatg ttctaaattt 40020 catacagac tcaggtgact acttgtaac acaagccaga aacaccccac aaggtgtaag 40080 tactacgggg ttttacact tagataaaa gggtagtact tattaagt tatattatgc 40140 cccatctaac acaataat tgtttgtgaa acttattat aatggtactg tctatgattg 40200 ggttagtttt aaactagatg aaggtacact atacgattca ggaatacaa ttaatgtaaa 40260 agatttaca gagtctaca ctcaatttgc aacactcata aatcctccta aaagtaattt 40320 aaacacagga tggataatt ataaggaag taaaaatggt acccagctt tagctgagtt 40380 taatcctatt attctactt cacatttaa atgattaga aagttaccac gccaagacca 40440 acaacctaac tgttaaggg tagtttatt cacattacca atgacggatg tagctaat 40500 aagaacgtat tatatagata atacatcttt ttggggtttt actaataatg catctacctc 40560 aacagttaga tatatgggtg aaatactat tcattagat gatgggggg aatcatatcc 40620 tactgttata tctaaacgtt ttagattagg gatgattta tatgtaggtg atacagttac 40680 aatgtctgta taccttaaag aatgacac tagtttatta aatggtact tcccttactt 40740 tgaaatagcg ggttatgata atgtatctca aacaataac ccttacacag gaggaggag 40800 agaagttaat tacttagt tatctacaga atggaaaaa ttctcattta cttttacatt 40860 gcagtattat aaccaagagg ctagcagtga cactgttaat tatatatcag cattattag 40920 atttaactgt tctaaccta aaaataatgg tgctattgta tattatgcac taccaaaatt 40980 agaaaaatcg tactcggtaa ctccatttat tacaatact tatgataaa gaaaatcg 41040 tgagatatgg agcaattgga tagagacaac aaagcaagat gaacttcaa cacatagtgc 41100 tgtagatacg acacaatg actactaca atatgtatgg atatcaa acgcaacgg 41160 tagagtttta cacaattag caatgtctgt acctcaggt tttactt tttattgtga 41220 tagttctata agtgacac ctaacataa aactataca ggtacgatac aagtagcata 41280 taggaata attaata ctachaata ataataca atggatttta gtgaccctaa 41340 aggtaaaga tattctttaa catataataa agatactaat ggttggcaag atatgaaat 41400 tcaatgtct agtaatagtc ttgggagg tactctgac ttagctcag gtaatacagt 41460 aaacttatcc tctcattag ataattatga ttttattgaa gtagtatact ggactagag 41520 ttctggacat atacaacta aaggtaccc agcaagtaca tctagtattg taattagaga 41580 ttttaactta gtaaatgatg gttctaatgc tagtgtagac tttttgaag ggtattgtga 41640 cattacagat aagtgaatg ttactgctaa aatgtcaaaaaataca taggggaa 41700 tagaaatact atgtctgttg ctcagtta tcaactggt catattgag tattagagt 41760 tgtaggacta acgtatatttt ataaggagt tttgtaaatg aaaatatg atattagtaa 41820 agatgaaatt gtgttacatt tagatag tagtatatc atgggttaca ctattgttgg 41880 agggtatgat gagaacaacg gtgacgtaaa aatttctagg tcaatcttc ctgacggggtt 41940 ttttactgag ttgttagta ctaagtatgt atactataag atactaacg aagtatatata 42000 taacaaaat tttaggata atgctaagg tattgagat gctgattacc aaccaccta 42060 agagtagtt cctaagaag attaaaaa gctagaagt gagtagaag attaaaaag 42120 aatgctacaa gattgttat ctaagaaagg attaata tggcactaa ttcacct 42180 attacagaaa atagtacaat agcagattta aaaaaaag ttatatat aggtggtgta 42240 ctaactgagg acagaatgt ctttgaagta acaacagact tgtagtaga 42300 acacagaaag ttaagttaac aacagataga gggttagcta aagatattga ttatactaat 42360 tacttaagag attagaaa ggtaggtcta tattatatag gagctcgtac attagctact 42420 atgtatgata aacctgatat ggaaaacatg gatgtactac ttcaagtact aaccttagat 42480 actgaggata gagtagtaca gatttacat acattatcta ccgctgattc taagtaaaa 42540 gtactatata ggtttgttaa cattatca acatcacaat ggcaagtagt acaagtcta 42600 ccaaataata atacacatc tcaataggt ggaagtcctt ttgattaa cacacaaggt 42660 atatattatg tgtctagtat gtcggatatg ccaaatggtg tatatgaagg gtttttacag 42720 gttattatag acaataatga aaatagaatg ttaagattaa cggatattag cacaggaaaa 42780 gaatatctta atgttaaaaa atcgtatggt agctggggca catggaaaac tgatttagat 42840 gtacaaaaaa taagtaagta tttattatct aatgtagatg gtgatgctga aagtaataac 42900 tactctttat ctgtatatac tacagacaac ataacatttc aacaggcaat agctaaacat 42960 attgaagaaa caagtaaaac tgtttttact tttatatac aaggggtgt tgtagggtct 43020 ccgtcctcgg ttagttgtag aggtgtattc atatcagatt caactaactt tactaatcta 43080 tatggtgttt atactgctat aggtactgat ggaagaacta ttaatggttc tgtaaatggt 43140 aatgtgtgga acacaacaaa aacactacca ggatttaaag agctgtggaa tggtgcacat 43200 aactttaaag atacaaataa aaaagaaacc atgtctgatt ctatatctaa ctaccagtat 43260 gtagaagtat acacaagata tagagctcta caaaatacaa aaggtactga taaaacaggt 43320 acactatgtc ataagttcta tatagacgga gacggtattt acacatgttc aggagcttat 43380 gtatcaggag actctatat tggatagag tattatagag taacactc tattagtggt 43440 gatacttgga chattaaga tagtgcagta ataata aagaccata tgttacacgt 43500 gttgtaggta tctctttacc atagactagg atattccta gtcttttt ctgactaac 43560 tttaaat atggtagat aaaaaggac taaaaaaaa gggaata tgcagttaag 43620 acacagaat atatatacat atgtagattt tgacgaagt gatggtata ttaagaat 43680 catacttaag cgtgttcata aacattagg agctaaaaa gatggttatc aacatagctt 43740 agcttttaaa cgaggtgtgt gggatggtta tgtagatttc tatgattatt ctgagaacaa 43800 attccccagt gggttgttac ctaagatgat aacattacta ggtgagttac atcaagaca 43860 taactttcaa tacgaatta ttgatgaaaa atctgaagc ttttagctg aagagat 43920 tgatgatgaa attackac tegataata cgtaggtaag attackac gtgactatca 43980 gtacgaagct gtatttata gtctagtcaa ttataatggt atatgtaagc aagctactaa 44040 tgcaggtaaa tttgcccct tagtagaa atattatag tgtgactcct ttaattcatg 44100 ggaactctct cattgagac atcatgagc caagcctata ataggaagg tgcaacgact 44160 attatgtaca tccaagtgga tggaacgggg gagaacctaa gtctcattag atatggttaa 44220 gatatagtct gaacttgta ggagactaca agaaggttag gagtaacgaa cctaccgta 44280 aaaaattga aaacagaggt tgctagcggt atcatagacc aactattacc acactagaa 44340 aaaggagagc gtgtagcttt ctttacaagc tctaccgaga ttttaatca atctgctgac 44400 cgtttaagtg aacgattgaa tataccagta ggtaagtag gttctggtaa gtttgatgtt 44460 aaacaagtaa ctgtagttat gattcctact gttaacctta acttaaaga ccctacagaa 44520 ggagtaaag tatctgctaa agtaaactta agtaaaaga tagctaaaga gatactccct 44580 aaatttgaag gtggtaaaa tcaaaaagg ttactaagt tattattaga aagtacaca 44640 cctaaaacta aagtagagca gatgtgctt gatatacttc aagatattta tcatattca 44700 aagacggatg ctgaagtatt aatggcatta aacaatcata atgttatttt ccaaaaagaa 44760 gtaagaaaga aaaatcaaaa gagctatgat aaatatcata aaatgcgtga gttcctagac 44820 tctatagctg taatgatagt tgatgaagca catcacagta aatcagattc atggtataca 44880 agtttaatgt cctgtgagaa tgcactatac aggatagcac taacaggctc catagacatg 44940 aaagatgagc tactatggat gcgtatgcaa gcattattcg gagatattat tgtaagaaca 45000 tctaatgagt ttttaatcga gaatggctat tcagctagac ctacaataaa tattatccct 45060 attgctaacc ctgatgatat agataatatt aaggattaca gggatgcata tataaaggt 45120 attgtacata acgagtttag aaatacactt attgcaaaac taacagctaa atggtttaat 45180 caagataaag ctacacttat tattattaac tttgttgaac atggtgagat actatccact 45240 atgttgaatg aaatgggtgt agagaatttc tttttacatg gtgaataga gtcagatatg 45300 cgtaaacaaa agttagatga aatgcgtaat ggtaaactta aagttatgat tgctacaagc 45360 cttattgatg agggtgttga tatcagtggt attcgttcat taatcctagg tgcaggtggt 45420 aaatctttac vakaaacact acaacgtgta ggtcgtgcgt tacgtaaaaa gaagagat 45480 atacacac agatatttga ttatgat atgacacata agtttta taacattct 45540 aatgagcgta gaaaaata tgagagaaaatttgaaa ttaagaatt aggaagtag 45600 gtatgggtag tgactaagac agaagaga ttatatgatt acattgaaa aaatcaaa 45660 ataatactt atcaataac tactaaaaaa gagttagcag agagctaga tgtctcagtc 45720 tctactttat ctaaaaaacct tAAagatta gaacaggata acaaattta tgttgttttct 45780 aaaagaggaaaaggtgg tattgttata tcactagtaa gagatttaga tacagatagt 45840 ctcttacatt ttaatcctac nationals ctcttacatt cttaatctaga ttacgctact 45900 gattacgaa atagattttt tcctagttac gtatatgaaa gaaaagaaa taaacgtaga 45960 aaaaactag aaatggttca atataatgct atttaagata aaaacaggaa aattaatca 46020 atatgaatt ttatagtag tagcttacct tacctacta aagatatttt taatatgtct 46080 tatgaccctg agggtttttta taaagcttat atattatgta agttatatga ccaatatgct 46140 atagcacaca tgaatgcta atattacaa cattacat ttcaatgg tgaatgc 46200 gtagatagac ataagcattt atctgagtac tacagaaaga aaatgttaca gatttatca 46260 cgagatagta ttgtaaga cttctttggt agtagacat ttaatacatt ctacaacttt 46320 tacttaaga tAAagata gacattaat gttttttaat acatgcaaa tgttttttaag 46380 ataccacat ttgggtttga gataaaaaaaccttacc ctatacctgc accaatttt 46440 tttagttccg ataatactt aactattat gaaaatttag taaaaggtat taaacgaggt 46500 gtaataaaaaatagaca attggggaa gtagagtctt taattaagtc atctgattac 46560 ttattaaatc ctgctgtagc acattacat cacatatata cacacctttt aaatgaagg 46620 atacatgata ttgatacaat gtttaaaaca gctttaaata tagatac tatttatggt 46680 atattaatg gcatgaaca tattatactt ttatcatata aataatatat agaacacacta 46740 atagaaaaaat tacctagta acataaaaac ttattaatta aatttattaa acatgtatt 46800 gtaaatgagt attcacctac tacaatacct aacaatgcta gactactat gttttaatg 46860 haaaagagt aaagcaaa tatcgcagaa ttaatggtg gtatagagt aagagactta 46920 ataggtataa gtttagtaaa cactacagac ttaagtaaac aagatattgt aatatagaa 46980 hurricane international hurricane tattca 47040 atgtatagta attacttagg tttagaggtt aatttaaaag aagttaagtc tataattgaa 47100 aaatattatt tattgatta ataccattg aaaagag gtatgttgaa ctataag 47160 gttattgata tagtaagga tgacacatat gagtaacga attagga tattacctaca 47220 taagtctatg aaggatatac attttgcaag agagtacta taagttac ctaaagtct 47280 atttgctaca gatcggaag acatgggtta cttattcaca gctaaaaa gaacaccaca 47340 cattgctgat aaatgtca atgaatcttt agctattaaa gtagagcaat taatgggtag 47400 tgataaaaa gatgatgaaa agtaacaaaaaaaaa tattagata gcttatatac 47460 agtagacatg ataataag acgattctgt aaactatgaa gtagaaagt atattaaac 47520 agaaatgtct aaagaagtat tagttagtt catagctgag aaagcaag aggactcaga 47580 taacttacct gaactagtag agaaactaaaaaatagaa gtcagtgaca ttaatggtac 47640 tgacggagaa ttttgact tttgaga cgtagataaa aagagagaac tattagcaa 47700 cttaagtatt ataagtatt ctacaggtttt ccattctata gaccagcaaa ttgaaggtgg 47760 tataggtaga ggggaagtag gattagttat tgcacctaca ggtagaggta agtctcttat 47820 ggcaagtaat ttaggtaga actagttaa acaagttta aatgtttta atttgccct 47880 agaggaaaag atgatagaa tggtattaag agcggaaaaaaatggtag gtgtacaaa 47940 gatcaatta cttaatggtg acttatcttt aaacacagat gcttataata agatacaaga 48000 acacttaaa aagaatagac aactgctagg taacttttat atcgttaac atatgcctgg 48060 tgaggtaaca storm windowtaat storm gagata 48120 acatatagat gttgttatta ttgattatcc taaacttatg cgtaacctt accttaagta 48180 tcaaagtgaa tcagatgctg gtggtcgtat ctttgaagat attcgaaaat tatcacaaga 48240 atacaatttt gtttgttgga cattagcaca aacaaacaga acagcttacg gttcagaaat 48300 tattacaagt gagcatgttg agggaagcag aaagattgtc aatgctgtag aggttgcttt 48360 tgccgttaac caaaaagatg aagaatttaa aaatggttt ttaagattgt acttagacaa 48420 agtaagaaac agttcaaaca caggtgagag atttgttaat cttaaagtag agcctactaa 48480 aatggttgtt agagatgaaa caccagaaga ggcagaagaa cataagcaaa tactagcgga 48540 acttaatggt gaagataaaa gtagatttaa agaaaaacct aataaagctg aagctattaa 48600 taattctttt ggagggttga gtttttaatg gatgacttta ctaagcttta taaaaaagta 48660 cgtagaacat ttacacgtaa taaagcagaa tgggattata caaatacagg attaagaacc 48720 ttccaattaa aaggaactaa tgtatgtgtt acattactag actctataggc aaggaataat 48780 acaacaggat ataagtacaa cgttatgtct aataaagtac ctgctatacc ttgcaataca 48840 catcaagaag tattaagc attgaat aagttaaaaa attgagaaa agccttgaca 48900 atgtatttgt taaggcttat acttttatta taaacataa agaggtgta agatttgaac 48960 ttaatgag aaagtaa atttaaaaac ttaaagtca ttaaagca cggatttata 49020 gagacttaa acacaagta ctctgaaag gagttagagg atgtctcaac cgatatattt 49080 atacattag atattacgt atacattaag tattggttgta attgtttta tattaagccct 49140 aaagagta ttatagagtt agattaaaaaaaaaaaaacactt aagaagtag 49200 attattatta tggaattaga attaataaattattaacg aagattgtttt agaaggtag 49260 aagaaaatac ctgacaatag tatagactta atagtaccg accctcctta ttatattaat 49320 tataaaacca accggaaa aaaaagag catagatttg gaaaagttat ttataatgat 49380 aaactaac acttattat aaattatatt gaggagtgtt acaggatatt aaaaaacat 49440 agcgctatgt atatgttctg ctcatcagag aaagtagat ttttaaca acattagag 49500 aaaaattta aaaaaaaa tatgattta tgggtaaaa acatcatac agcaggagat 49560 ttaaaaggtt cttttggtag aaaatacgaa atcttatttt tagtagtaaa gggcaaaaaaa 49620 cattttaatg ggagaagatt aactgatgta tgggaatttg atagggtaag tggtaaaaaa 49680 caattacacc aaaatgaaaa accattagat ttaataaaac aatgtattat gaagcatagt 49740 aataaaggag atgtggtttt agatgggttt attggtagtg gcactactgc tattgcttgt 49800 atgagtacta accgcaatta cattggtttt gaattagacg aagaatacta taatttagcc 49860 agtgaaagaa tagaaaaata taaggagata ctaaacaatg aaaatgacaa tacaggaact 49920 acaagataag actgaatttt taagacacgt aaaggtatat acggaagaag caatggatat 49980 ccttgaagat atattaagag gagagcctta cacagatgag gtatgtgaat tgatacattt 50040 ttattcaagt aagctactaa atgagattaa tgacaatcat atgtttaaat tacaggaggtt 50100 tgctaatcat gatgttatag aaattagtga agagggagta aaataatgat aaaattatta 50160 caggggatt gcttagagtt attagataca attgaagata gtagtatcga tgctattgta 50220 acagaccctt catatacat ttcaaagaa aacagattta caactatagg tagagctggt 50280 attgattttg gagagtgga taaaaatttt gatctactt tatggatta taagctata 50340 ccaaaagtta aaaaaggtgg taatatcgtt gtgttttgtg acatgagaca attcacaccc 50400 atcattaata ctatggaaga attaggctgt gatttaaag atgttattcg tctgaaaaaa 50460 tctatcccta tgcctcgtaa taggataga cgatttatt ttgatactga atttgctt 50520 tattttgtta aaaaggaga taatggact tttaccgtt taggatgaaa attgaaaga 50580 ccttgtatta aaacaagtgt aacacctaga agtgaaaagc agggcaagg acacccaca 50640 cagaaacctt tatatgctat ggaatggttg ttagagtgct taactaatga aggacacatt 50700 gttctagact gcttcatggg aagcggaaca acaggtgtcg catgtaaaaa gttaaataag 50760 aattttattg gttgtgaatt atcagagaa tacttcagta tggtacaaga tagattacta 50820 aaatacaa attaaaaaaaacccttgac aacatgtttg ttaagggtta tacttttatc 50880 ataacgtact aaaggaggac actaatgaaa tttatatttt ttacagatag ccattttcat 50940 atgtttacga attagtaa acctgatgaa gatatgta atgatagatt taagaacaa 51000 attgagacat tacaaagt atttgattta gctagagaaa aaagctaa agttatattt 51060 ggaggatt tattccatta gagaatgcg gtagatacta gagtatatta taggtattt 51120 gaaacctttg ctaagaatca agatgttaaa gtctatatgg ttagaggaa tcatgatgct 51180 gtgtctaatt ctttatatac ggaatctagt attgatatct ttgaacatt acctaatgtg 51240 gagtaacta aagatttacg tagtgactca ctttctagta agtacaatt actagtgt 51300 gcttatggag atgaacaga agaattag gagtatatta aaaatatta ccaaaaagat 51360 aaagtaata tattagtagc acatttaggc gtagagata gtttacagg taaaggctca 51420 cacagattag aaggtgcatt tggttaccaa gacctattac cagaaaaata tgattttatt 51480 cttcttggtc actatcatag aagacaat ttaaacaata accctaatca tatgtatggt 51540 ggttctctaa tgcaacaatc cttttcagat gaacagag ctaatggtgt acatttaata 51600 gatacagata agctacatc aacgttcatt ccattagata ctagaaggtt tattacagtg 51660 caggtgaca atgtaccaga tacatgaat gatttagta accaaggtca ctttattagg 51720 tttattggta ctccagaaca agctaagta attgaatttag ataaaacaga atgatgaatct 51780 aatgtacaag tacaatgaa gaaagaatac acggtagaaa aggagtcga cgctgacgtg 51840 tctgacagcc ctataacgat tacttctagc tatgcagaca atactatcc agaagcaaaa 51900 gatgagattc tagagtgttt aaggcggtg ctgtagtatg atagatatta ttataagaa 51960 tattaaacca agtatatata aatctaaacc tattttacag ttcttacata aaaagac 52020 atatgatgta tgtaatgtta aaatattga tgatgcgatg taccttatta acaaagtatt 52080 agaggaagct aactatgctc attattac gaggattatt gacagaag attgttatat 52140 tcgattat gttcacatc aatgttctt taattgtta aagaaggtg gtacaaatgg 52200 ttagtttaa ttagtagag atgaatact tttagctat tgagcatatc aagctaaatc 52260 tggataagca aggtcttgta cttattgagg gttattataa aacaatgat agttttgaa 52320 gtaatggaac aagtaaaacg agcatgatat cttctattac ctagcactg tttggaaaaa 52380 ctgagaaagg ttaaggca gatgatgtcg tttaaggta tagagaaa gacctacg 52440 ttaagctttc ttcacata ggtaagacg agtatttaat cgaagatac cgtaacata 52500 aagaacacaa gaaaaggtt aagctgttct gtaatacaa agagataca ggctctacaa 52560 atgatgttac ggatactcaa atacaaggt tattttggtat tccttttaat acatagtaa 52620 atgctattat atatggtca ggagacattc caatgttttc acagctacc gandaaggta 52680 aaaaagaaat actagaatct attack ctgaattta tagcaagcc cagaagtag 52740 ctaaagaaaa ggttaaagaa gtagagaga aaaaaaaaaagaaaaa 52800 aactagaata taaaagaaac ctaaaaacaag aaaaataa taatgagta aaataata 52860 attackttatt agagcagagagagagagagtt attackaaagagtt 52920 acgagataa atttaaagat ttagacaatc agattggtgt atgtaaggt agtattccta 52980 aagttgaaga ctttgaattt gtatttagtg aaattatac aaagctac caagttattg 53040 aaagattaa cacaatatt atgaataat tattgccatt attgagtca gaacaaca 53100 ataagaatac aactctaaat atattaatc aattaaca atctattaat aaactagata 53160 caaatgacca ttgtcctgtt tgtggttctc ctatagataa tacacacaa ataaaagaaa 53220 aagaaaactt agaattacaa attaagaag aaaaaactaa attackctcag tacgacata 53280 agagcaggc taattaat aagaagaag agctactac taatctag gactacac 53340 aatttataca gcaagagat atagaaaga aaaaacatga tgatgatatt caacggcaat 53400 atagagaaca gcagaagta tatgatgaaa ttagccaatt agaaacact aaagctatt 53460 taaaagaacc aacattaat gattactctt atagaga acctaatga gattacaca 53520 aaagaact aaagatact ghaatacata ttgaxaaca taggaaat atagtacaat 53580 Tagagagta gaaaaaaaaaaaaacag ctgtagatgc atttagtaat aaggattac 53640 gttctgtaat attagacttt attacaccgt tcttaatga gaagctaat gagttattac 53700 aaatattagc gggttcggat atcgaaattg aatttcaaac acaagtagaa aatgctaagg 53760 gagaacttaa agataagttc gatgttattg ttaagaataa caatggaggg gagtcttaca 53820 aatctaattc agcaggagag caaaaacgta ttgacctagc tattagtttt gctatccaag 53880 acttaattat gagtaaagaa gatatatcta caaatatagc cctttacgat gaatgctttg 53940 acggactaga cactattggt tgtgagaacg tagttaaact actaaaagat agactaaaaaa 54000 ftaggtac tatttttgtt attactcata ataagagtct agcaccttta tttgagaata 54060 caattacggt agtaaaagaa aatggtgtag ctacactaag aaaggaatta aataatgaaa 54120 ctaaagatta aagataacca gtttgcatct ttaacagtaa attacacaaa caatgcaaag 54180 ttacatatag ataaattcc tgtttctact ttagtagact ggtacccttt aagtaatgca 54240 tacgagtata aagctagtaa tgactttgga tatattgaac taaagagatt acgctctagt 54300 ttacctatgt cttatggatt aacacaccga actttatata aaggtgaaac tgttaaatgt 54360 aaactaggatt tattgtataa tgaaaaata aagaata atgagaaat tattgagaaa 54420 gctaagttgt acggtttacc tactatagat gaacccttca caagtaag tgtaagcaa 54480 ggatttagtg acttaggtgt tattttcca acactaaaa caatcagtac aaacgagtac 54540 ttaaaagata aaaaattga agagattaac atctttagta agaatcaga ggattatcha 54600 ttaatgaag tactcaagta cagtacaca ctggtagatg atacttag tgacttaagt 54660 aaatctata atatgttact attaatgag aaattgttt ctatatagga agtgactgaa 54720 aatgaggttt gagacttt taagtcaag gattgaca cccaaagaga atactgtagg 54780 agaattacga tattgttgtc ctttttgtgg ggaacagaaa tacaagtttt atgttaaaca 54840 gtctttagac gctactaatg gtgtatca ttgtaagag tgtggagaac atggtaaccc 54900 tattacttt atgagtctt attacttat tacaggtaga caagctttg agttactga 54960 aaaaagaat attgatatac aattctcacc aacattagaa atatataca cagatttac 55020 tgaagtgag aattattac taggcttta tggatataca aagataata gtagtataa 55080 atcaaagca cctgaactac ctatagggtt taattgatt aagatact taataata 55140 agagtagta ccgtatttaa gatatctta attagaggt attackac agcaatcct 55200 agattacaac atagttata ttacagatgg ttattgttat tcttatgta ttaataatga 55260 gaaaaagaaa atagtactta gaatagtgt tatattttt acttatgaca atgaaggtaa 55320 gtatatatac tggaataca gaagtattga aacaatcca tatattaat ctataaatgc 55380 accttctaaa cctaatgagt atggtaaag cgatgttata tttaatttaa atagctag 55440 taaacaaag ttgttgtta taactgaggg tgtttttgac gcccttacat tgatagta 55500 cggtatagct acgtttggta aacaagtttc aaagatacaa gttaataacc tcattcaag 55560 tattcctaaa gaacaccta tatatattat gttagacaca gacctacag actttagtat 55620 taatttagct ataagctta tctcacatttt caatgtagtg tatttac cacatggtaa 55680 tgaagatgct aatgatatgg gtatggaaa agctttgt acttgaac acatagatt 55740 tttagttaca cctgaaagta ttcaaagtta caagttacaa caaaagttaa aactttaatc 55800 ttgcattata atgtatagta tgttacaata catatataaa aataaaggaa gtgttatttt 55860 ggaagagaaa gatattctac atttgtaga tgagtatgtt acagcattac gtgtaggtaa 55920 tgaacagcgt atgcaccaat tagaagagtt aggtaaagaa caaacagcaa ctttaacaga 55980 tgtatgaaa gctattacta acttattgtt aggtgttaat aaacaaatgg ttgacctaga 56040 gcaaaataca gagttaaact taaacattct aattgatgct ttatacaaag ctgagttagt 56100 taacgatgac gtattaaaat atattgagga agcaattgaa gaatcaaaag aaaaggatga 56160 agaataatgg aaaaaaatat tagtacacat acaaaaggta tttcacaaaa agatatggac 56220 atgtggttag aagctattac acaaggaaca gtagaaggca aggaattaac tgaggacact 56280 gctaagcaat tacatcgtat tggagcacgt agtgtatcgt tagatgaggc tactagaatt 56340 gcacgagcaa ttaatgccgt tacagttcaa gagtatgcat ctgcctttaa tgatgctttt 56400 aatgctattg atttgttaat gattgttatg gaagataact tagatgtaac tactgagcaa 56460 gtagagaagg cgcaacttaa attaaaaga aaacgtgaaa agtattaga agaaaaaaaaaa 56520 Gaaaaaaaaaaaaaaaaaaaggcat aaaaagtagtg 56580 cagttgaga aacatgacaa atagtaaaaaaaggtgat gtattcgaaa gaagattgc 56640 haaagaactt tctgattggt gggttttcc tttagg tctccagt caggaggtgc 56700 ttcatggggg gctaataata atgctgtcgg tgacattgta gcacctttag agtctaattt 56760 tccattagtt gtagagtgca aacatagaga aaattggatt atggacaatg ttttactta 56820 taataagaa cctcatacat ggtgggaaca agttatagga gatagcttac aagttaataa 56880 aactccttgt ttatattta caagaatag agcacagtca tatgtagcat taccttatat 56940 agaatgta tatgtaagt taagagatga agaataccct attgaga cggattttat 57000 tgtagaaaat gttagaaaag aaacattt ttatgatgtt cttataacta cgatagatgg 57060 gttgactaac ttacacctt cttatat atcttgctac aaaaaaag agattaacc 57120 atatagagtt gtcaagtcta aaatatctaa agttagtaaa aaagaagata agttgattga 57180 tgatttactt gatggtatat aaggaaggga tactagttga ttacacaaat aaaaaaacgt 57240 gatggttccg ttggatatta tgatttaagt aaagttacta atgctatttt aagagccaac 57300 tcagaaacag aagaatat tgaagatgtt attgattctc ttgtagatga tgtagactct 57360 ttactagaag aacaagacac tatcattact gtagaattaa tacaagatat agtagaagaa 57420 gttttattta gtagtatgta taaagatact gctaaagctt ttattttata tagggataaa 57480 aagaaaagag agcgtaaaag agacttattc aaaccaagaa aagaattaaa accctatgaa 57540 taccctgaat tattagaata taaagatgct atacgccaaa gttactgggt acacactgag 57600 tttaactata catcagatat tcaagactat aagaataacg ttaaatacaa tgagcaaatg 57660 accattaaaa aagctatgtt agcaattgct caagtagaag tagcagtaaa gactttctgg 57720 ggtgacctat atcatagaat gcctaaatgg gaaacaggag ctgtaggtgc aacttttagt 57780 gagagtgaag cacgtcatgc agacgcttat tcacatttat tagagatttt aggtttgaat 57840 gaagagttta aaacaattga cgatattcct gctcttaaag aacgtgttga tgagttagcg 57900 atgcatgtaa aactaagtaa gagtgaggat gatatagatt acgtactatc tgttttatta 57960 ttttctatat ttatgaaca tgtatcttta tttagtcaat ttttaattat gatgagtttt 58020 aataaatata aaaacttatt tagaggttta tcaaatgcta ttgaagctac atctaaagaa 58080 gagcaaatcc atggattatt tggaacagaa atcattaata ttcttagaga agaaagacct 58140 gagtggttca acaaagaaat ggaagaatgca gtttacacag cctgtaaaaa atcttatgaa 58200 tcagaaacac ggttacttga ttggatgtat gaagaatgggg aactagagtt cttacctaag 58260 aaagtagtac aagaatttat taaaataga cttaataact ctctagtagc tgttgggtat 58320 aataaacttt ttgatgttga tgaagagtta ctaagtgaag tgtcatggtt tgatgatgaa 58380 gttatagta ctaagttaac ggacttttta tctaaacgtt ctgtaacta tacaaaattt 58440 agtaattctg taacggaaga tactattttt tcaacggaat ctgattttga aaatactggt 58500 aaacgagtta c'aagaata agtaaacgct atttagac t'aaaatgat aaaggcag 58560 tgtataga tgagtaattt tgaatggtta aaatgatt ctagagtttt tctagaacgt 58620 ggttatta gtgatggtga aacaccagaa CAagatta aagattattgc agattgct 58680 gagaatttt taggtattga tgggttttct gatagtttt atgattat gagtaaggt 58740 tattattcct tatccagtcc tattattggtct aatttcggga agatagagg atttagtatt 58800 agttgttttg gtagttgggt agatgatact ataccatcga tacttaatac tgctagtga 58860 gtaggtag tgagtaata cggtggtggt acagtggtt acttcggtaa catcagacct 58920 agaggctcag aaatcactga taatggactg acagtggtt ccgttcattt tatgaagcta 58980 tttgagcaaa tgacagatac gataagccaa ggatgttatg atgataaac tgaaatactc 59040 acagagaatg ggtatgaatt atttactaat gtagttagta gaaagatgg aaaaagtt 59100 gcacaggtaa cagataatga tgaatagag ttgtagagc ctacaggtta tatggaattt 59160 gtacctgaag atatgaatt agttcatttt aagatagta aaatattga cttattagtg 59220 actaagaacc samaaatggt ttttaaatac agaactaaaa ggactataataa agaaacagga 59280 aaaagagaaa gtgttttagt acctgagtat agaaatagat tagcagaaga tatgccatta 59340 catatagagcg tttatttagc acattcttca tttgctaaag aaggcagagg actcacattt 59400 aaagaacgtc ttttggtagc cttgcaagca gatggtagta ttattaaaaa ataccctaaa 59460 tctttgaagt ttagatttag taaagaacgt aaaaaagata gactattatg gatattagat 59520 ggtctaggag ttgaatacac atataatgta gacaaagaca ataatcataa tatttatgtt 59580 aatatgggtg aagaattacc taaagaattt agtaaatggg taaatttaca aaatgtcaca 59640 caacaatggg cttatgattt tattgatgag ttgtctcatt gggatgctag tagaagaacg 59700 gataaatcat ttatctacat gagtgtggtt gaacataatg tagacattgt tcaagccata 59760 gcttctatgg taggttataa atctcgtaaa tcagttgatt taagggaaag agaacctaat 59820 aaagccacta tgtataaaat atatctatct gaaggtcaat tatttggagg ctcaaatgtt 59880 actgtggaaa cggtacaata taaaggtaaa gtatattgtg ttgaagtacc tactcataa 59940 cttgttgtaa gaaggaaagg gcatacatta gtttgtggta attctacacg tagagggcgt 60000 tttagtcctt atttacctat agaacatgag gatatgatg agtttttaga gattggtacc 60060 gaaggtaatc caattcaaaa cttaacacat gcagtaacag ttactgatga ctggtatta 60120 gacatgatta atggggataa agaaaaaaga aaaacatggg ctaaagtatt aacaagaagaa 60180 60240 gtatataaag acaaagggtt aactattaat aactcaaatt tgtgtaaaaa tttgcacctt 60300 tagtaagtaa ttactatcga aaaatccatc taaacggtga atatctaagt taaaatatat 60360 gacaacaccg tgctaaatca gattataaat ctgtaaatgc ctaacgacta tctgtaacct 60420 attcacataa gtgaagggat aaggttagag ccaagtggta taagtatga gtaataatca 60480 agtaaatctt atttaaatcg aaatggtgga cttccttatt aaaggaagatg atatagtctg 60540 ctctatatgg aaaatatag aagttcatat taaaataat aattaagagg gtcgaaaatg 60600 gagtaccata tttataaaat tashaaaaaaaatacat cggaattaca 60660 tcaaaacag ttcacacaca atttaaaaat cattagaa aagctagat aggctcaca 60720 actaatttac accaatcaat gatgaaacat ggtgaagaga atttttgt agagaatta 60780 tacacttta gtacagagga taaaaagttt gcttacatgg tagagcaat ttttatagac 60840 atgtacgaat ctgtaaaaa agttataat atggagatag gttttgggtg gatataatg 60900 gatagacgag gaaaaaaaaaa tccgatt ggtaaaaaa gcgctaatgc taaaaaagtt 60960 attgttgatg gcgtagttta taaaaattg ggtatatgct ctgaagagct aggaataaac 61020 agaaatacat taaccagaag atgtattct gaaaaatttcc ctaactaa atattgttaa 61080 ttagagaact ggtagtgatt acgaccact attgaacatg taggagtga atatgttac 61140 ctataaga agattggtca ttgtatgtg acctatctag tatgaacctt gttaagtatg 61200 atgaatggaa accacggat gctgtagaga cacttgttta ctttttagat gctgttatgt 61260 ctgagtttat tagagactta gatatctaa gagactcaga tgaaaaaaaaaagaag 61320 catttaaatt taggagaga gcttataact ttctgttga gaacagagcc ttaggatag 61380 gcgttcttgg taccattca tacctacaat caaactcat accttttgaa agtattaaag 61440 ccagtcaat tatgagag attattaat tattaaaga aaaaacttat aaagctagtg 61500 agcagttagc taacttat ggagagcctt ctattttaaa aggttatggt agaagaatt 61560 catgttgat ggcggtagct cctacgactt cgagctcatt tatcctaggt caagtttcta 61620 aaatcaattga accttttatg agtaattatt acgttgtaga cactgctaaa gtaagaaaa 61680 ctatgattta tccttacctt aaagactt aaaaaaaaaaaggac aaaaaaag 61740 ttattgagag tatcagagat aatgatggtt ccgttcaca cctactttc ttaagtgatt 61800 atgaaaagga agtattaaa acatagtg aaattaatca atatatata ttagaccaag 61860 cttctacaag acaaaat attgaccaag gatactt aaacattatg attack 61920 aacatgttac agcagaggag ttaatgaac tttactctt tgcatggtct atgtatta 61980 agtcattgta ttcacat ggtacaatg catcacaca attcaattta tctaaaattt 62040 gtattaattg tgaagcctaa agaggtgact aaatgataa aaagaagcg ttggattac 62100 tagtagac tgagatata ttcaatca atgatttttt ctcacaagta agtaatgtac 62160 aagaccctat tagatgttt atagggaag atgatacta agcagatagt aatchagta 62220 aatttcagct agagtttatt tatatacat atgtgtacat tcttatatat gaagtacat 62280 taaagctatt taagctgat ggtacggagc agttaacaca tgtagctgat attgaaacat 62340 ttaagatat tattgacaca ttagaaaagg atgatacaga aaatgaaaa agtgaatagt 62400 ttattagagt taaatacaac atcagacaaaacaggatg ttattgtcat ggttacaca 62460 gatgagtgtg ctaaatgtga aattttaaaa agtgtgatc ctcttttcga agcagaagga 62520 gatttacta aacctgtttta tgttattac ttagatgata aagatgtaga tagagaaaaa 62580 gcggtcaagt tattgacat tatgagtaca cctgtactta ttggttataa agatggagaa 62640 cttgctaaga agttcgaga ccaagtaca cctaaaaact tatggatt agatttactt 62700 taatttgtaa ttacctacta cttatgctat acttatatta gtaaaggta gtaggttttt 62760 tcatgaaagg atgaatagtt atcgcaaaaaaaacatt actatatat atagtgata 62820 gatttttaa tacatgta aaaaaaaaaaaag atgaatttac taaagctatt aaagttaca 62880 ctttaatga agatgata gaaaagata tggacaactt agctataa tcaactaggt 62940 attacktag nationalaattackgc attackattac natgatag 63000 tgattgaaaa atatgcaag cacggtggac agtaacata ctataccgat tcagtaattc 63060 cttactatgt gcttaagat ttatcagctc accctaaatc atcagttgta tatagaatgc 63120 gtagtaagtt tagtaaaa gagatgata atagcttt gagtttcatg ggaaaaaag 63180 tcattattga tattcagtt gtatttcctt acgtcaatcc ttacgatatt attagaagtt 63240 tatacgatgt taaaacgaat gtagacgagg ttcatctatc attcctcgt attagttcta 63300 tacgctaa aaagtaag tactacacgt atgataag agcttataa ctaaaaccta 63360 ggtatacgct tgactttgca gacaaattaa gggtttcttt gtccgtgtgg aaaatgtata 63420 tctatattct tgctagtaaa gaaaataaag attatgaaac aatagaagac ctacttactg 63480 attaaaaag acaaagaaag attaagattt aggtgattttt gtgagtacag caaatagaag 63540 agatatagca agaaagatat ctgagagtac agggtattat atccaagacg tagaagagat 63600 actagaagca gaaacaaaag ctatttctga attactactt gaagattacg ataaggtaaa 63660 gaatcataag tactttcaaa tagaagtagt agagcgtaag ggtaaaaaag catgggatgg 63720 actaaataaa acatacttca ctttacctaa tagaaaggca ctaaagttta aacctttgtc 63780 tgaattagat aaagttatag atgtattaaa caaagaggaa gaaaacagtt aaatatttta 63840 tatagcataa gatttagtat ctactcttca tgtatttagt tggtagtata tgttttgcta 63900 ttatatacta tttatttaac agagattgag tcaagtttat acttgactct tttttttatg 63960 tttgtata gtttaactat aaggagctga ttgaatatga aaatgaaaga tttagataac 64020 ttacatattg ttgtagtag tattagaat gatacattac ctgatgtagg gtatatggtc 64080 ttagaaaata taaaaagaaa gtaaaaagaa atagtgacat acatgaat catataaaaac 64140 agaagtaaaaaaataac aaaataat tgattaat aaaaaaatta atgcttgtag 64200 aagtgtttat aaaattta ttgagtaaa taatttcgt tatgataacg ggttgaattt 64260 tttaaaccat agaagtttta gtgttttgta taataatgat tttattccta ataaaga 64320 taaaaaatgg actaggaag taaatacta agcaactaa caagctatgg actagctga 64380 ggatgcatat aaagattct ttaataat atcaggtttt cctaagtttta agagacaca 64440 aagtaacggt tcttactatt taataggtac tatacatgta gaacgtcata gatacgact 64500 acctaattta aaatgggtta agttaaaaaaaaggatat ataccggaa acaataaa 64560 atcagctact attattaag aaatgatag attattagtg tcagtgttag tagatgaga 64620 acctaagact atacttaaaaaccacatac tgaggtatt ggtatagacc taggattaa 64680 agatacacta ttcacctt caggcgttaa gattacagat tttaggaaa aaaaaatt 64740 agttaaatta cataagtctt taaaacgaca acaaagaaaa ttatcacgaa aacaaagaa 64800 gtccaataac tggtctaaac aattattaaa agtacaaaga ttatatcgta aaataagcaa 64860 cattaagaag gatattaaac aaaagaaaat actagaaata gtacaggaaa acccacaatc 64920 tatcacaatt gaaaatttaa atattaaagg tatgatgaaa aataaaagat tgtctaatag 64980 tttccaacaa ataggattag gctacattat tgaatggctc aaatggaaat gttatcaata 65040 tgatatagaa ctaagacaag tagagatt ttacccttca agtcaaatat gcaatcaatg 65100 tggaaataga caaaaaatgc ctttaaataa aagaatttac gaatgtgata attgtgatat 65160 gatagaagat aaagatataa acgcaagtat taacttaaaa caagcaaaag aatatacaat 65220 actagtataa aagaaaaaga gaagttactg agaactagta tcttacttaa agtctaaaca 65280 aatacggtag gctatatcgg aattaacgct ctgggagagg tttttagacc tgattgttaa 65340 tacaatcaac ctcgttgaat ggagaaactt tctaaatata catttaagta tgtttttagt 65400 agcaggatta agttcctctt ttttttattg actactatga ttagatatgc tatactgtat 65460 ttaagttaaa gaagggattg gtaataacat gaaagtttta attttatacg actatatcag 65520 agaggaacac ttttcagtta gtaatgatgg tagtgttaag aatgtactat taaatacacc 65580 taatggtaga gtactaaac aactattgtc taatatttct ggtattaata gagataggag 65640 cacaaaggat tatgacattg atttttata tcctaaagta cctacaccta ttaagaataa 65700 ctatggtaaa acaattaagt accaagacgt taagttatct gaagttaaac cttactatga 65760 aagaatgagt caaataatca taaacaataa gtacgatatt attatcctt taggtaagct 65820 aggggttaaa tatttattaa atgtatcagc tatcggtaaa gttagaggtg tacctaataa 65880 agtaactatt actagtgaag ataaaaaaca tgatgtttgg gtattaccta cttatagcat 65940 agagtacaca aacgttaata agaatagtga gcgtcatgta gtagctgacc ttaagttat 66000 aggtaagttt gtagaacaag gtgaagatgt atttaaacct aaagaagtta agtatgaact 66060 tgttacaagt attgagcgtg taagagaaat atttaataaa gaagtaaaga atgataatca 66120 tgacggtgta gacattaccg catgggattt agaaactaac tcacttagtc ctgatagaga 66180 aggaagtaaa cccttagtat tatcaatgag ttgggagaat ggtcaaggtg ttacaatacc 66240 tttatataaa tcagacttta cttgggagaa tggacagcaa gatatgatg aaattctttc 66300 cttattaaaa gaatgggtag ctagcaaaga agacattaag gtactacata atgctactta 66360 tgatataaat ttccttatgg caacgcaagg tttcacaaac tttgaaaata atcaagacac 66420 taaggtaggt tggtatttag ctgtaacaca agaacaagca gagtctctaa gattatcaga 66480 ccttgcttac gaagtaacag atgtaggagg atatgacaaa ccccttgaag attttaaaga 66540 gtggtatgta ttgaagctac taagattctt atcagataaa ctaaaagata ttaaaaaaga 66600 aataaaaaa gttgctaaga aagaatataa cataaaagca aatgagtatg atacttggtt 66660 gaaaaataaa ctcgataaca ttgatataga actaacagat gaagaataagt attatggtat 66720 cacagaagag caaaaaagat atttagagtt aaaactaaca cctgaggtta ttacaaagaa 66780 tatgcttatg gattctgaat ttaaagaagt agccgaatca tcacctgagt atatgagttt 66840 atctaacaaa gctaaagatt atgtattagg tacatctatt aatttaatta acacgtataa 66900 agacaatact aaagttatta atgaggtaga tggaggtgac tttaattatg attggattcc 66960 attagagctt atgcatcctt atgccagtgg tgacaccgat gtctgtagaa gaatatactg 67020 tgatgttat gaaaagttaa aagaacaaaa tagacctaaaa gcattggact taatgtcaat 67080 aagttaccct agattaatta gaacattagc tagaatacaa tcaaatggtt tacattgtga 67140 cctagaatac atgcataaaa atgatgaatt ttatattaat gagatggaaa aaacccacca 67200 agaaattaga gaacattggg ctatccaaga atttgaggag actaggtata atttatacca 67260 attagcctta gcagaacatg agaagaaacc atctgataga aataaagaaa tacatgagta 67320 tagagctaaa tttaaaagatg aaggttggaa gtttaaacca agctcaggtg accataaagg 67380 tgaagtattg tatagcattt taggtataca gttaccttat agtaaagaga cagttaagga 67440 taaacctttc agtaatggta ctaaagaaga tgagttatca tggaaagatt acaaaacaga 67500 tactaagtct aaagctgg cattatcttt ggttgagaat gagataata aaagctact 67560 agacttactt atttatg cctctttgca actaaaaga aattcttta ctaagaaatt 67620 acctaaaga gtaataaga atacacataa tttacatggt aactataata gtacaggaac 67680 tgcatgtatt acaggtgatt ctttagttat tactgataaa ggtataaaa aaatagaaga 67740 cttatcaat atagaaag aaaagtatt tagtagtatt gatgtaggta tgttaag 67800 acagggaat ttagaaaag cttcacactt ttttagt ggtgtaagaa atggattaaa 67860 gattacttta gagatggta ctacattaac tactacttta aaccacccct tattacgaaa 67920 taattatta agtaatactg gtaggggttct aaaaaaaaaaaaaa ctaagcattt 67980 actagataat gattggttg tagctgaga ttaaaata ggtgattata taaaaatgtc 68040 attattattct aatctttatta attaagtta tattgattta gatactaag attattatata 68100 tagtaaga aaagtatta storm aagctataca ctacctatt atgtactctga 68160 agattttgct gaatggtacg gtatgtatac agctgatggg tctttttcta caaataacgg 68220 ttcattcagt ataagattaa ctaatagtaa tcttgaagtt aggaatagat tctttaacct 68280 aactaaagat ttatttgata ttacaccata ctacattagt aataaagata gaagtgattc 68340 tattgaattt tcttcaattg gtttaggtag atggttagaa catattttta atatgcaaag 68400 taaagcatta aataaagaaa tcccacaaca aatattagat agccctaaaa gtgtacaaca 68460 agcatttctt aagggtttaa gtttagatac tgcaacagaa aagaaaaagt atcctagttt 68520 gtactataat actgtatcta ataaaatgtc tttacaaata agaacaatgc taatgaatat 68580 gggtatctat tgtaggtatt ctataggtaa agtttataaa aataataata gaaaagtaca 68640 aaatgaatgc tattctatac aaataactta tgatgcatta gataaatttt acgatgaaat 68700 agggtttatt gaaagtatta agcgtgatag agtaaagtat aaatcagaaa atctaaaggc 68760 attaggcaga agaaacggta ttcttttata tgataatgtt ttattaggta aaataaagaa 68820 aattgaaaaa ataaaagata tggaattttt tgatttacat gttcctagta gccattcatt 68880 tgtagctaat aatattgtaa atcatataac tagcaggctt tctagtaaca accctaacct 68940 tcagaatctt cctgctcata catctgatgt aaataagtttt gattatcacc accctattaa 69000 acgttctttt atctctagat ttaaagatgg tgtaatttta caagccgatt acagtgcctt 69060 agagatgcgt attacggcac tatatacaga tgataaagaa atgttagaga tgtttttaac 69120 aggacaagat attcataaaa atacggcaag tattatgtat ggtaaaagta tgaaggacgt 69180 aacagcagaa gaaagacaag ccagtaaagc tgtagccttt ggtttaattt atggtgaatc 69240 ggaatttcg tttgcaggta aaaatatat gacagttgat gaagctactg aaatatttaa 69300 taagttttat tctaataaac ctgctattaa gaagtctata gatgaaactc atgagtttgt 69360 tcaaaaacat ggatatgtag aaaaatgaa tggacacaga agatatatac actcagcaca 69420 atctagagat aaaaagatta aaaatgaggg tcttagacag tcctttaaca cgattattca 69480 aggtacaggt ggttacctta ctaacatggc tattacttat attgacgact ttattcaaaa 69540 taggaatatg aaatcgaagt tagtagctac tgttcatgat agtattgtag tagactcacc 69600 tcctgaagaa gttaatatta tggctaaagt tattgtccat gtaatggaga accttcctta 69660 tgatttccta aaaaayaaa ttaatggtga gttaaggcag tatcctatag atgctgatat 69720 agaatagggg ctaacatata atgatatggt agaatacaac gagagtta taaataatt 69780 taattcatat aagatata tattaata actagcctta cagcaatta aggacta 69840 tgaatcaggt aaaactactg agagcagta aaaaaaa acggaata ttaaaaata 69900 tattgacagt ttcaagtta tatttag taacctat catataaaa tattgggg 69960 tattatggag attackattag attackattag ttcatgag ttaccttaa agatacaa 70020 tggaaacaca cagacgttta atattcatga tgaactaaaa cttagtgagt atacaatca 70080 agacgaaatg taccacagt cgtctaaatt tgcatggtgg gctccttaa aagaacgtgt 70140 gagtattat gccgaagcag agcaacgtaa gttagaaaaa atggagctc aacttaatct 70200 aaaattaga gctcagtacg aaaaaggg aaagaaacct aaaagacc aagtagagtc 70260 tgctgtattt ctttctgatg atatcaca gcaagcaag gttgtagag catggaatta 70320 tagagaaaaa cattacatt atacgtaaa agcttttgaa acacgtacaa ctatgttagt 70380 acagattagt gcggaactaa gawaaaaaaaaatggt ggtgttacta acccattac 70440 acattaggta ttgacaaca aagaaaaca tgttatacta attaagtaat ttttaaata 70500 aaaggaaaa agatattatg gatttaatc aatttattaa tcagcaatca gaaagctac 70560 aatcaagtgg ttttgacaat gaggtagaga cgtacaacc aaagaatccg gttttgcgat 70620 taggaagat taaggacgtt aacaataatc aaattaataa agagtctgca cttgtacgtg 70680 tactaccgcc tgtagcaggt tctaatgagt tcttagga attagaca tactatta 70740 actatgttaa aaagatggg gcacaaagt tctctatgct tactttaccc gagaaagtta 70800 actcatctgt tgtagaccct tatgtaata catggttaaa gcaagtgta caatttagta 70860 acttccctaa taaacctgca cgacgagcat atattcatgt gattgaatac tttaatcaa 70920 acggacaatt agttcctaac acgatgac aaggtaatgt tgttattcaa cctatggagc father gggtctgtct caattgattg accgattaaa agataaaatg ttatcaccat cacctactgc tacacacagc tttatttcag ccgatgatgc attccctatt aatattgcta aagctaaaaa aggtgaaaaa tcatggaatg taactgttta tcctacagta aaattaggtg ccttacctca aggttggga cagcagttat cggatttag tagttagct acaccaacag aagaaaata ccctaacttt gtaaactggt tgattaaca tgttaatac acagaagttt ctcatgata ttttaattc agtagagaa caaacacatt agtagagaa tcatcaacac aagagcaaac acaagctcct acgcaacaaa gtgtagca acaattacct agtaatttag gtggacaaaa taacacacaa ccaaacttta ataatgtaca acaaccaaca ccacaagttc ccccacaaca aaatacacag tttggtcaag gaacacctgt gcaacaagca ccacagcaac 71580. gcaaccaaca aaagtaatcc atttgagac tttgatgcta ataacattga cgattctcaa atcccattca acacaatga atcaacacca cgattctcta aacaaaatca acctaagagt gtagatgatg tattagcagg tttagattta taataacttt 71700 atagagtgct atcttagcac tcttttattt aaatttcata taaaaggatg atataatggc 71760 tagagcaaaa aaaggtaaag aagtagatac tacaaattta aatactattg acttaggtaa 71820 agaattaggt ttaactttac tatcagatag taatagagca gatattaaga atatcattcc 71880 tactatgatt ccacaatatg atagaatttt aggtggaggt attcctctag gaagacttac 71940 agaagtttac ggattaactg gctcgggtaa atcgaccttt gcagtacact tatctagagt 72000 agcaacacaa ttaggagtta ttacagtttg gattgatatt gagggaacag ctgataatca 72060 acgtatggag cagttaggcg tagatgtatc taaattattc tcagtacaat caggtgaagg 72120 aagacttaaa aacgttactg aattatcagt agaaactgtg ggtaaagagt tagagtactg 72180 gattgataca tttaatgaga aagcaccagg tattcctatt ttatttattt gggattcact 72240 cggagctaca cgtacacaag atgaaatcga tgcaggagta gaccataaaa aacttggaac 72300 aaaagcgaca tctactcaaa aagtagttaa tgctatttca cctaagctta atgatacaaa 72360 72420 tgaccctatt aagtctacag gcggaagagc ctttgagcac ggtgctagtt tacgtattaa 72480 agtatctaaa ggaaaagaat cggaattaaa gcaaaatgat tctatgacag gtaaacctac 72540 gtataaagga catgttatgc gtattgaaac taagaagtct aagttatcta gacctggaca 72600 aaaagcagaa gttgatttat tatcaggtta tgaagtaggt tctgaggaag acactgttca 72660 attaaatggt gttgaccctt atcatactat ctataaagaa gctgttgaac gtggtttaat 72720 tacaaagggt acatggcgta attatgttac gttaaatggt gaagaaatta aaaagtacga 72780 taaagactgg gtaccaaacat taatggataa tcatgaacta tatttagaat tatttaatag 72840 agtttatcat gaaaacttcc ctaataagta tgtaccttta agcaataacaa agtagacat 72900 72960 taagagact aaagaagtg taaatgaata atctaataga tagaaatt aatagtgtta 73020 aagaagcatt aggcaggggct atacaaatg acgtattgcc cttaccttat attgaatag 73080 cagaacgttt taaaaaagct agagatacta aggaagctat tattgtagaa gaagcaggct 73140 ttccttacac tgattctaca gttatgtata tgagcatgt agagtcagg tgggcagggg 73200 gttactctt agtacgttat aatggttctg aagttaaagt acctaaaaca atacactatt 73260 ctgatatcta tgtatcaaat gatgtacaca ggattagat tgtatttgag ggagcacatc 73320 cttatgaaga agttaataa tgggaataga tattatag acttagatgg tattcctact 73380 gactttgta gagacttaga catgcttta aagagatata aaaaccttag atggtcatta 73440 tttcataggt acttagagg tatgagtcat gacttgaaa aacagagtt acgggaatac 73500 attagatgagc agttattaa gttagttaag attagatgata tchaagta agtagattttt 73560 ccagggtata ttaaaacgaa actaacacta cgagtacaga acagttatgt windows 73620 aaagtata aacgtactga acttgtaggt aaaacagatt atacagtaga gtccttaaca 73680 caggagttaa atgtggtt agaagaaaat gatttactta attgtctt tgatgataca 73740 caatttactg agtachaag tgaactgcta aagaactcc ttattac agtaagaa 73800 bōkacgcat ttattgtttc aactgtagct ataggttag aggtagagcg ttcagaaata 73860 actaaggagc taccagact windows gttaaattta aaaaatgc actaccacgaa 73920 aaaagata gagatacat tagacaac aaaatagata gacaaatca tgtatgggaa 73980 taacacaat aagccttcctt ttgttatat tattaatgaa ataataca taggggtt 74040 ttttctatgt tataatgtaa aaataatga ttggagctta attattatgg ctaagaaaaa 74100 tattaatgaa gttaaaac aagctaccgc tactgtagca gataagtatt tacaagttca 74160 agtagagca gatggttata cacgtacaca ccgtggtcag tatactaca aagtagtaga 74220 taataggga gatttattct tatacccgat tgaacagat ggtagaggaa atattaaat 74280 tatgaaaaag gctcctgttg cttatacaga tggagaccaa attcatttg tagttaatac 74340 tgttaaagac ccttacaacc atgcttttat tagaactgaa atattaaag gtaagataa 74400 aggtaaacaa ttaattcaag cgttttagc attcgttgaa gaccgtttca gctttggagt 74460 atacaatgta ttccttgcta atacaagaa ggatgttttt gctttagttg atgctgaaag 74520 taaagatgct aaaaagtag taggatagta tgagaaacct catgaagacg tgagcgctga 74580 gtttcctgct agtccgctac gtaagacgt taaggagta gactcaggag aaggtcagg 74640 agatacttca gaaccttcag tacctaaaa tgtaacagta accgctaag aaacaacagc 74700 tgatattaca gctgataaa catataaagg atgacttagt ttggataat taaatttata 74760 aaggtgac cagctattaa aaagtgaga gaacaagca ggtaaaacat cattacaat 74820 tgataactta actgctaca cagactaccc aaaggtaca tataaagtat ctttctctaa 74880 tgaatcagga gatcagaaa agtagatgt tcctgcgtttt agactaag atattaagt 74940 agtatctgtt actttagatg ttgaagtttt agatttaaaa gtaggagaaa cacataattt 75000 agtagctacg attgaacta gtaacgcaac aaagctact tatacatta cttcagaca 75060 tgatgatatt gctagtgtat caagtaaagg tttagtagaa gctaaagcaa aaggtcaaac 75120 tacaatcact gttactactg atgatggtaa tcatacagat actgtaactg tagttgttaa 75180 agataaagta cctgaagctc ctacagatgt aactgtagac cctaaagaaa caacagctga 75240 tattacagca taatcggagg taaaaataaa tggaaaaaac attaaaagta tataaagatg 75300 gtgaagtagt aggtactaag actgctgaac aaacaggtaa aacaactatt tctattagtg 75360 gtttaacagc agatactacg tatcctaaag gaacttataa agtagcatac tctaatgagt 75420 ctggtgaatc agaaaaggta gatgtacctg aatttaagac atcaccacat agtgagctat 75480 aataaattaa agtccaactt aattgttggg ctttttttta ttgacttata tttatttata 75540 tgctatagtt aaacaagaat taataaagga ggtactatat ggatattaaa acagtatact 75600 taacttcaga taacgaccat ttgaaagtta aaaaattaat ggaaagtaag gaaaagtata 75660 ttgcagttac gtatgataat aaatcagtaa gtaaggtcaa tgtcgttatg gttattaatg 75720 ttattaaaga cctagtgcat atgtataggt ataaaattgt tgagtatggg ttatctaata 75780 taggatagga taggaatg gtaggtatt tattagaaag tattgaggt tgatgttatt 75840 tattttaat gaagtagctt cacacacaga acatttatcc gaagtatag atatgttcga 75900 cgttgaaagt gtagtatctt ttgactcggc attacattta gctagtgata atacgtatga 75960 ttctgttatt ttttaggtt ttatatacaa taatgaggat tacttaagt aaagaatt 76020 attaaaggat acaaattat actttgtttc taataataac ttacctgaca attaggagtt 76080 tattacagta ggtgatgact taaagtacct atccttatta gagcaacttg tagtattaga 76140 agataagac ctagacatta acttagtca gtatactaa vakacggctt ctaagtacac 76200 tgagttgttt agctttaaat ctacttatga ggaggcaaa gaatgggtc tagtaggtta 76260 ccccgcagat atagtattac cttattgac tgacaagtttt tacaacgtaa atgatttgta 76320 tgtactatac gaagtagcac ctgagtataa attacctta gcatatgaat gccttaagga 76380 taaagaaaaa gttattgttg ttataggttc acaaacaga ggtactagtg atatccttac 76440 tttctatgta aaggttatg atgttaatag tgttgctaaa acatcggag catcttataa 76500 tgaaaattct atatattca gtatatttat tgagtcat atccatgtgt taggtgagaa 76560 Tattgattag tattatta cggaggag tattattaaaacagtagag 76620 agttacaagc agttattgta gtgtgtttc ttaagatga aggtaagta gttacctcta 76680 aatttaata agtattagca agttttggta tgatagagt aaatcgcaat gattaaag 76740 atattgtaga taattagg aagacacat acttaatga cttgaaaaat aaagcagtta 76800 aaggtgagt gttattagag gacttagag atgtagaag taacaagta ttgaggta 76860 atgattatca tgagaagta tcatcttatg tagtagcaca tgaaaaagaa ctatctagac 76920 tagggaatt acgaagatt atagacaaa ctgcataccc tactatttg tttgatgaat 76980 taagcgtac tattggttaat gagctaaag ggaataagtt actagaccat aaagtaagta 77040 agtatacttc tactgaggaa gagaagagc tggttatctt actgtcggac ttccatgtag 77100 gttgtgcttt tcaattta actaatgagt atactttga ggtactaaaa agagattaa 77160 atcagctact acaggaaact atttaggata ttagtaaacg tgtattagt atgttacag 77220 tatactttgt aggtgattta atagagcata ttaattgag agatgttaac caagctttg 77280 atactgagtt cactaggca gagcaggtag haaaggaac tagactatta attgacttct 77340 taacagaatt atctccatat gtatggggta atttacgttt cggtatgata gcaggtaacc 77400 acgaccgtgt acagggtaat aagaaccaaa aagtatacaa tgagtgta gcttatattg 77460 tattggattc tttactgctg ttaaaagaaa acggtgtatt agaagttatt gagattatcg 77520 acatagaaa atgtatat actattaag actattaag acacagtag taacttaat attattata 77580 accatggaga tggacttaa ggtaaggta agcatattcc taatttatt gagaacactc 77640 acatgactt attackattaca ggtcatgtac atcactttc agtacaca gagattaca 77700 atagaatgca tattgtagca agtagtccta tgggatataa caactatgct aagaactac 77760 acttatctag aacgaagcct tcacaac tactatttt aaaaaaa aaagaca 77820 ttgacattaa aactgtattc ttagattagg gagagataat atggacattc tatcattat 77880 agccttaaca ttgcttatca ttattattgt taataccaca atgactttg taggtagtt 77940 acgtggtgag cgtgatttag taaaaaaagg agtaaccct ctacccaatt ggcagtacta 78000 taatgtgtta ttacctatt tatgtgtat tatcctctta ggtattgttg tttattttgg 78060 agattcgatt tataaaatta caaaggtt agaggttcttt ttgctatta ttgcgcttat 78120 tgtaatagat gtattgttaa cagcgttagt attattagta ttgagtttcg taacaaaaaa 78180 taaagaatag taaagaaggg agtctggtttt atactgact ccctttgtta tttatggtat 78240 attagatatg aggtgatttt tgttgcaat aaatttttgt aaatttgata atgaattat 78300 taagacaaaa gtaagtgaag gtgtttactc ttttagaggt gttccttatt actacataga 78360 acatgtccaa gatgaaactt ctgagtagt attagtatat aacatacata gtgttgatga 78420 tgagtacca aaagaat aaaaataga aacagtagt aaactatta gaggcggtac 78480 attaagt atacatta agtcaatgct acctaat aagagtata aaaagtata 78540 tgaacctcct atctttg ctaatattat acctttaggt acagatacaa ctacaggtgc 78600 tgtaggtaa gggtttttcg aagagaaa agatagagta actattacac aaaagaagg 78660 cactaaagtt atacatggtg atatacagg agtatttata tgtttatcta atattaatg 78720 gattagtcc tatactcctt tagacagtat attacaat tatcaacgta ttaagggga 78780 taggaataat gtctgagata actaaatttct atgagcagga tattaaat ttatagaa 78840 ctagagaca tatgtttaa tatgagaga tacaagta tatagaat attagaat 78900 ttaatgaaaa agctatttgt caagtaaat gtagaactga ctgtttaatt ctgatagaa 78960 acggtactgt tatgggtata gagataaaaa cagaacgaga ctctacacaa agacttaata 79020 aacagttata ctattatagt ctagtagta agtagttta tgtgatgtgt catgataagc 79080 atgtacctaa agtagagcaa attackaaa ggtataaaa ccatcatgta ggtattatga 79140 gctatattaa ctttaaaggc agtccagtag taggtagta taggaagct acgccttcac 79200 cactaagag tccttatcat acactaata ttttaggaa gcaacattta atgactatac 79260 ttaacagtt aagagattat atacatacc taactgata taactatagg gagcacggta 79320 aaatactaa caatgaggc agttatatag aaggacaca acgtatgaga atgaaaagt 79380 cagctattat taaccaagtt attcattatt taggtgtaga gaacttat aagatattta 79440 ctagaggtgt tatctatggt tatagtaata gatggcagat attagagat gatttcttta 79500 aagttataca gaacggagtg agggtattat atggcaaga ggaacctga tgcatttaaa 79560 cctaaatcta acggatataa acatcaacct gttaactttg ctcctacagg taacttatca 79620 ggtagaagta cttcttttt taaaaaaa agaaagata tatcagatga aagtattgtt 79680 gttaaataca aacctttgtt tgttaaaagg ttgataatg ttactcctac cgacattaaa 79740 atacaaaga atatgcgtt agacttaatt agtgaagctg tgaataaa gagaataat 79800 cttgtaatga agcaaaagg taattaca caactattt tacatacgga tagtttt 79860 tatgtttata gaggtaagaa attaataggt aaatgtagca ttcgtgaca acgtacattt 79920 agaggtacac atttaatcta cattttagt actagacata gatatctat acgcaaaat 79980 agtagattag aagaaag aaaccaaaag aaatgattat aaaggtgg taaataatgg 80040 ttataatattt aagaaaaaa gctaaaaaaaaataag tactttattt aagaaactac 80100 aaagtaaga tattacacta ttaggattgt cctatgatag tgatttc cctagcggtg 80160 windows accttatta gaggacatat windows agatggtata gatttacga 80220 aaagtaat agttactgag aacttaaaac ctgctattgt aggtatgat atatgataa 80280 gtgattcagg actaggttat gttaaaacag agcagttaaa tAAagatta gaaatactg 80340 repeat nationaltctaaaggaaaaagtac ttcaaaag aaagtagaca 80400 ttgtatcaac ttttattgaa cctactatta tgtaccaaga tactatt aaaagaat 80460 taaaacttag attackacact atcgagatg tatccctttt aaatgattac acacatgttg 80520 tatacttact agtaactaat agcaatg acggtcaatc attcataggt actatgta 80580 accaaggtac attaaacaaa ttatagactc taaaagttct tacattcttc aagggtaata 80640 atttaatcaa tagaagtgtg ttttctgtta agttagatac gaataaatat cattatagtt 80700 tatataatac acatgagacc ggtattttct ttttagatga tgataaagac ttaattattg 80760 cttgtggtca atcctatgta aaagttaggt ataaagatat tgttagtagt aaaatagga 80820 aagttagtga taataactat aaaatgattg ttaatcttgt tggtaatgat gagctaacaa 80880 ttctcttata gtataatact cccttaaata tgtatactaa ggtataaata tacgtatcta 80940 agggatttt tatacgtatt tttttcaagt agttagttaa tttttaaaag gtattattct 81000 tattttaaaa ttatatttat aaaacattaa aatatctttt aggtataggg ttttagaaaa 81060 aagatttata ttgcttaaaa tagttacact atagtgtaaa aaattagaat atcctttatg 81120 aaaataaaat agatgcagaa attgtgatat attatatagt gtaaagtata aaacagttga 81180 tttgataagg ttatgtgaat acacatactc cttatttag ttcacacata tgtaaagaca 81240 cttgagacaa gaagggaata tataatggct agaaaaaaga atttaagaaa taaaaaatct 81300 gatataagg tagttccaga taggaagt attctatcta aactata taataacta 81360 ttaggtcta aagtggataa tgctatagat gaagatgtta gttatgatga tattatagac 81420 ctatgtaaag agtatgactt agagttatcc aaatctgcca ttacaagata taagagtaaa 81480 cgtaagaag ctattgaaa tggatgggat ttaggagaac ttattgataa aaagaaaa 81540 gttagcgcta ctcaataca gaaaaaagaaaaccctaga aagaattaga tagtgagaat 81600 tatacacctt ttgaactggc tacacagaat gtacaaaa tattgatga tattcaata 81660 ctagatatga ttattcaaa aggtgctaaa ggtttaact ttgtagaac attagaccct 81720 gctttaatga ttaaagctat ggaaaaaaa gatagaatta cgggtaacca actaaaggt 81780 atgtcattca taggactag agaactaatg atttaacaac aagcacaaga tactgctatg 81840 acagaagtta tgcttgagtt tattcctgaa gataaacatg aagaagttct tcaagaatg 81900 gagcattac agagagtt ctataaaaaac ttagatttag atgaagg aagaaagtta 81960 aagatacat taggagt aggctataca atagata tgaggtata catagacag 82020 aagaaattag ttatattcca aaaagatg ttaaccact tacagatata gtagatatta 82080 taacacacct acataaggt gatgtactta gagttaaca aggaaccaa gagatatat 82140 tacttagact aagtactga aaacataagt ttactgaagt gtcagagac ttagataag 82200 aaaccatgtt ctataaaagg tattgggtac tgtataatgt atctattaat tctttactaa 82260 cttttgatgt tattttagaa gacgatttag tagaatctac aaagttaag ttccctaaga 82320 acacaattgt agaatgta agaataatc agaatcag tgtagccaag gttaagata 82380 ttttagtaga tagtaaggt aattattct atgcactttc aggagaaca tctttatata 82440 atgagaata acttaataa attaaaaatt atgattgac acacctcatat gggtgtgtta 82500 ttctttatt acaacaata aaggagcaa ttgattga ttattacatt aaatgaagaa 82560 gagaaagcat tattagaaaaaagcaac tatacgccat tagtagaa taaagagttc 82620 atacaccaa aagagata tattgttaca agttaata aaggtgtacc tgtgactgat 82680 attgctaagg aagctaaagt aagtaggggt ttgatttata cagtgttaaa cttcttaaa 82740 gtaccaaaga aacatagaa atctagagta gcaaacgtg taaagcaat tactaatgat 82800 aagaataag tacaagcctt aattaagat tattaata tagattaca agtattatt 82860 Aaaaagtata acattcaata gatggttta tattattatt taggattgta tattattga 82920 agaaaatcag atttaaaga gaagcctta gaagatacta tcgaggtaga attagaggtg 82980 tcatatgcgc aaagaacgaa ttgtagatta cttgtataat gtaagaaca ttgatataa 83040 ttacttac aggattag aaatagtttt atttachaa gatctttac aagacttaat 83100 acctgatttt gatactcta gtaaagagat taatgaaagt aatttatacc tatgtacaat 83160 accagaagat tataactccg accacgtaga aagtggtcag tatataggta tagatgttgg 83220 gtatgtatct gaagaccctg cttttgacca tttaataggt caagttccta gaagtgtata 83280 tgagaaagcg catgttatgc aaccactaat windows atactgata tagattac 83340 tcaggctgat tgattaatg acattacaagt attagtgatg window 83400 agataatta agtttaatgt caataatct tattacacat ttagaattg ttgataagca 83460 ctactttgat agtagtatgg aagaagcact actaaagtat tatgagtta aaaatcctga 83520 ctattatta aaacattttc ttaactaaa agaacttgtc ggagacaata gatgatata 83580 ttgtccttta ctgttaaaat gtattaaagt tatagactaa gttattatat tatagtagt 83640 aaaggatggt gcgctatgag taaaaaagca atattgctt atgtattat cttagttatg 83700 ttagccttat ctatatctac ttattacgta tcctcatact ttatcatga aaaaaccaaa 83760 tcacaagtta cagaccaatt aacacatcac ggtaaactaa aaaagaata gatgtagag 83820 tacgtaggag attacacgct window gtagacaca aagcatactt tatggaaaaa 83880 ctacctacct attaccagg agaacaagt gataaaagta ttgatatgag attattagg 83940 actagtaat ttagagagg tgtaacttt aaacttattc gtgtgtatac ggaggataat 84000 gaataatc cagtacata gtataggttt gaagcagtac taaaaaaa gtaaggtat 84060 gatagtctat gacagtagta attatactag tatgttttgc tattatatac tatttattta 84120 acaaggattg agtcaaggtt atgcttgact ctttttttat gctatgttat aattaaata 84180 taaggagatg ataaatgatg aaaaaaagtg atttagataa tttgtatatt gtggtcgtaa 84240 gtattaagaa tggtgtttta cctgatgagc gtataattcc aattggttta gatgtactaa 84300 gtaaagtatt agagggtaaa actatatgga cagttaagaa agaaattaaa catacatttg 84360 gtaaagatga attaaaaata tttaaagata attacaagtt cttgcaacat aaaattgtag 84420 accttgctac aaaaggatat aggtaggtga tataaatgga tatagtagat aaactcatgt 84480 taggtttat tttattgttt tatgtaggtg tatttattg gtacttatgg gaagtctgga 84540 attaacttc tttaatatct gatatagtta ttaagtatta tgttcgtaag gagtgggtta 84600 aaggtttatt accttattg attcatcaag ttattattac gttagtttgg gctactctag 84660 tattagtacc tttatactt agctatataa tgataaaata tttgatagga ggttactaaa 84720 tggaaatagt attgagaat gatgtagag gatttatat ttgtgtcata gatatgaag 84780 gtaagtag agtatcatct ttaaaaat cagtaaaaaa gtatacccct gaaattacag 84840 ggtatacac agaaaagtta ctcttggaat taaaaatacc atgtacatat gtaaatgcta 84900 gtgaagtaga aagttttg CAGAATTA aagtagcacg tattgcgctt CAAGATTA 84960 ctaaagattt atataataa ggcataacaa atattatt ctaaagggtg gttagtagt 85020 atacagaaaa atagaaat ttaatccata ttacatatag tatctttggtt agtattcaag 85080 attagcag attattatta attaagaag attaagtagt attaagtact 85140 tatgtgttgt agatgtatt attgttaa ttgttgagga aggatta tacacctatt 85200 ttgataggt aggtttaaaa gtgcctgaac gtattgcact tggtcattta gcaaaagtt 85260 tacagtttac atatcggaa tcaataag atttagaaa tcaaaata gtgttgacac 85320 ctttaacatg ttgctttata ctaagagtaa caaacgtta gaggtgattt tttgtgta 85380 aagaaaaagt tcatagacag ctactaatg ctatagaat attagcaact tachaagt 85440 ggtggtcttt tccaaaagaa ttaagtccca cagaaacatt taagattatt aactggaaag 85500 aagatacatt agtatttgaa gttagagata acggtaatta tataggtagg tttagtgtag 85560 caactcctat tattgacttt cattatgata gaattaaaaa aacgacagca caatacatga 85620 taaattattt tgctaaacta gtatgtaaag atatgtatac gtattataaa ttacagagag 85680 gacagtaaaa atgaaaaatt taaataaaaca aaaacgcttg acgttggaat tgattagtga 85740 taatctaaat acacaacata acttaaatac atcggttagt cttgtagatt atagtataaa 85800 agactttaca aatagaaaag tgtatgtaag aactaaaaaaa ggtttagaac ttactaatat 85860 gaaaagttta aaaagtactg agtcattaga tttattattt aagtatctag aattaatttt 85920 aaaaggagat gtataacatg ctaacaccag aacaaagaac acaattaaaa gagtatcaaa 85980 ataaaaatgac aaaaaagaaa aaaataatgt tgacttacta aataacaagt tgtataatta 86040 acttaacaaa gaaaaaggag attgataaat atgaaaaact tatataaaat tttaacagga 86100 gtattcttta gcactacact attagga ggttgtgctt actactcaca agcagataca 86160 ccgacacaca attataagga agacaaaaaaaatgattc atctaagta 86220 gagaaaaaaaaatcaaaaaaacaactg ttcaaata gaaaaaat 86280 aaccaagtac aaggtaacca agcacacag aaccaaaaa tgxaaggc aagcagagt 86340 gacataatg victory tgctgagtat gcgacaatg gacaatcagta windows 86400 storm aagcagaatt agaaacaga actgaagcag ataagctag tggcggtgga 86460 ggcggaggag cctcatggaa tttgcaggt gctaatgaga gcttgagca atggttacaa 86520 cgctcgcaac aagaaaaggc tgaggctgga gtacaagcaa attataaaa gtataggag 86580 aaaacaatg aaaaaaaaga actacaataa gttttagag agcaatt 86640 atggttagat agtaatagtg aagaaggagc taaagcagat ttaagttata ctattttaag 86700 aaatgctaat ttagtagatg ctgacttaag gagtgctaat ttaagaggtg ctgtcttaag 86760 gtatgctgat ttagaggata ctaatttaag aggtgctacc ttaaaaggtg cggatttaac 86820 aagagctaac ttaacatgtg ctaacttaag ctgtgttgat ttagatgatg ctaacttaga 86880 aggttctgtt ttatatggaa ctgatttata ttatgctgat ttaagaaaag ctaatttaac 86940 agattccaga ttaaatgagg ctaatttaga atatgcagac ttaacaaata ccaatttaac 87000 agatgctaaa ttatcccaag caagtactca aaattcaaa ggactaaaag tatactctat 87060 agataatatt ggaactttta atggtaaagt gacttatatt cctagcttag atagagtata 87120 cgcagggtgt tggataggta gtttagaagc gtttttagaa aagggattag agatgaatga 87180 aggaaataat agtaaacttg aggaaataag agatgcttac tgcttttta gtaaacgtaa 87240 atagatataa ggatgattaa ttatgaacat tgtagaacaa cgaaaaccca taaagagtaa 87300 gcatattaac ctaactaaac atgcgtatga acgttatact ttaagagtta gtaacgatag 87360 taaagaacgt gcttgtcagt ggtttgctag tgctttaatg caagctactt ttgaacatac 87420 acaaaaaggc ggtaatgaag tatatgtatt taaaaattat agaattgtta ttgataagca 87480 tctaactatt attacagtta tagatactga nationality tgggaggta taaagaagc 87540 agagaaaa atagatacgt atattaaagg taagctaaa agaactgtta cacctattt 87600 tactaatta tagatag tactaatta ccatgagca tactaatta tgattaaac 87660 aagaaaccct aagaaaaag attattaa caaaatatt gttgaacttg aagaaaata 87720 atctttacta ttataagta taggaggtgt aaagaaaaca gcacatagt attatgtaga 87780 atttaaagac attcataaaa gattaagga ctgatataa tgtgtttaaa agatttaatt 87840 gagataattack windows attacatactactac windows 87900 attgaagcag actatgatgt tattgtttta cctaaagta aattgatat tgacgattta 87960 aaagcttatg tatatggatt taatagattt atatagagc aaattgtatt aaggacgtg 88020 gatataatgca agacttaaa agatacac aacctgaatt agatttattg atagaaagc 88080 atgaacaatg gctagctaca atgaaaagg aaggaaaaa gctcttttta cagtgtgtag 88140 atttaagaaa tcttgacttt cattccgctg accttcaata ttcactatt gtaatgtcta 88200 gtttaagtga tgctaaccta agttattgtg atttaagtta ttctgattta agttacagtg 88260 agtgtatatc tacgagattt acacatgcta gaatgagaga tactgagttg cctcatacta 88320 acttagaagg ggctaattta ataaaagcca acttagaaaa tgcctgctta gctgaagcta 88380 atgtaagtga agcagacgct aggtgggcta atatgaaaaa tgctaactta agtatggcta 88440 atttaaaagg tgcagatttc ggtggtacaa acctaactaa tacaacatta tattatgcta 88500 atactcttga cgtatttgga ataagtatat atactataag taatgtactt gattttgatg 88560 agcatgtaac ttatttacct gattatgata gaattattag taattataat gaatataccc 88620 ttgaagagtt tggtaaacta gaacctacac ttgagtacga agaagataga ataaaagaag 88680 tctcaaagaa aatagaataa aagaagtctc aaagaaaatt aaattatctt acgatttctt 88740 taaaggagtg aaagaaattg ataaaattta attcagacga acataaacat atacttaatg 88800 ttatggatag attaccatat acttgctggt tagatactgt agatggtgag tcaggtgctg 88860 actttttg tgtattaaat aggacacact atgaacttac tgaactaggt atatgattt 88920 atgattatga tagttggtat atgataccat atgacaaga agatttaatt gatatgca 88980 taaaaagaga tatagaggag gaagggaat ggtaggtag gtgattacat ttttaattgt 89040 tttaggttatt atattgctaa gtgtactaat tattgttatta ccagatttaa gcaagcaa 89100 aaaacgtaaa gagacgcag attackatta tagccaat actaagaca tggcttctga 89160 gtactatgaa agtatata cacctactga acacattatt caactaag tagagaggt 89220 aattgaaac aagaaag agtatactgt ctctactgta atttatgact cttctagtaa 89280 tgagacaaa attackacttac atgttaacga tagtactta aaaaggtag tgtataaaga 89340 tacgtatgaa tacatctacg attctaatac aaataccaa tacattatta atatgtaac 89400 atatgagtcg agtatcttat taaaacaga tgagtaat aattaaag atatacttaa 89460 taaagtacct gtcacagcta agcatacatt taaaaatgag ttgcttaatc gtaggaatga 89520 atatgtgtta ggttattatta caatatat ttatgatgat ttactgcta aattacaa 89580 gatggttat gtacaagact ttagtacact agaagatttt tgtgataagt atgaagctta 89640 ctgtagattt gttagaattg attatatga ctgggtaaaa gaagtaagaa ctattaatgg 89700 gtataaatta aagtagata ttaaacctta ttttaaaatt actgctacta aaacaagtaa 89760 atacgaattt gtagtaagtg atgatgtatc taatgttag gtatatag atgatgct 89820 actaaaaac aggtagtgc aaaaagcaat tgatatacag gaaatagtag aggaacatt 89880 gatataat actgtggtat tttaaaaag gagaagtag ggaaatttccc tactttttc 89940 Atatatagt gttgacatga ataagtgtaa gtttataat agtataata gttaataat 90000 tatagaggag acattaatca tgaaaaaaat attaagttta gttttatccg tactattgt 90060 actaacaata atcaatgtgt tgaaaaacca accaagta accaagta accagaatc 90120 tcaaataat gagatgcag atgaccatac ttcatacgta cctgagaata atggaca 90180 aaagatgtt agtggagac aaagatgt tagtgagaa cgtaaagat ttggggtac 90240 agagtatcaa gaggtgaa cacataaccc aaatgctaaa gtgtttaatc aagatacagg 90300 agaacaggtt caataagag tagaggagc acttattatg gatactgga aagaacaga 90360 catatattat tcaaaaaaaaaggtgt tataagctat atagactt cttccttgct 90420 ctaaaacaatg ttcaacatta ccaagaagtc agtgataca tgaaccacca gaaaaaaaaa 90480 ttacagaca taggaaagag agaatattgt aagaaaata gtatacaata tatatagaga 90540 ttgatgctag aaagtctacc ttataacata tattaagtaa cctacaaaga acatttaat 90600 actctatat agatagtaa gagtatta aagatatag acatgtatat aggtagtgt 90660 frequency shake shake aggtag nationgt aggtag 90720 tatataagta agtaaggt aaagaaaaac tatataata agtagataa gatcagat 90780 aagtacaca windowaca actgatatta aagtaccta tattacagg aaatagta 90840 Tagtaaaaaaaaaattt gatgacat agatagcag tagtagtat atagtaata 90900 gctaataga tagtaata atactgtat aacagttttga agaatgaat aaagaag 90960 attattaag taacttaagt attaatagat attctaatag taagtaatag atattaagta 91020 gtaggtaagt aactaaaaga aagtagctaa aagaaagtag ctaccactat cacttaggtt 91080 aggtaagaac agttacctag taatttcttt acatcttcta gatagataaa taagtagata 91140 ctaagtaata gctagtaagt attaaaaga aaacaggtac atggtatacc tatatactaa 91200 gtagcaagta gcaagtagcaagta agtagcaagta agtagcaagta 91260 gaacaggtac atgggaattt ctctgcttcc ctccttcata gtgtatatat agttaggtgt 91320 ctaactatta gatatctaac tatttatttt tatatagttt taactactgt gaactatgtt 91380 tatgtagtat taaactatgc tgattatg ctaaactatt ctaatgtata gttaaactaa 91440 gctgaagtag tatttactgt gtataaaggt atatttagta ttagatattg tgtatatggt 91500 atactataat tctgaacatt acttatttaa tatatatata gtttgtttct gtggtagtat 91560 tgacttaatt ttccctagag taaaagttta atatatttag taatttccga acaataaaga 91620 aattttaact atttacaca tatgtgttga cagtatatta cttatggttt atactaagta 91680 tataaagtta aaggagatga tttattga agattaaaag agaagtttcg tttatagaat 91740 taatgtatat gtattaaa ggtgatataa aaaaaggtcg acactattct actgatagtc 91800 agtttattgt tgttataact gttgatgata tatcgtttta taatgcattg tatcctaata 91860 aatctattac tattactata cctaatgaca ctaagtttat tgtagaagcg gttatagatg 91920 cttctactga gttaagtagt atagtagtta cttataagca aggtaacagt gtattaaact 91980 cagtatggta tagaagtagt attaatgaag ttattgacta ctatgtcgaa ggtaaaaata 92040 catggttatt gtctgttagt actgttgtag ataatgagtt agttactata tggaaagatg 92100 gtaacgtatt gtgatttggt atatagtaat attcagtata cttatatatg tacagcactt 92160 gtattatta gtgtagtact agtatataga ggggttaaat aaccgcttca ataaaaaggg 92220 ggattagttt atgagtat ttataagtat cgttgctata tttttagcta ctattagtat 92280 tgtactaagt ataaggtttg gtaagaagta ttataagcat gtactcgata attatgatag 92340 tgttagtgat ttagaatcag cttgtgtgtt tggtttatta tttatgagta tttgtattgg 92400 tactatttct attgttttga gtttaggtta tctaatagtt aatttgttac attgttaggt 92460 gtatttaggt atatagagta gggcatatta agtaagggta tttttagatg ttaattttaa 92520 gttggtttat tatcggcata tatcttgctt gtttagttac tattacactt ttttctatta 92580 aagataggga tattattcct gctacactag gtattgtagc tcttattata gttattattc 92640 ttatatctac caaagtgtta aatatgtagc ttaagtgaga ttaagtaagg aggattataa 92700 atgttaagtt ttattttgtt atgtgttgct ctaggtattc cagaactttt cttacttact 92760 atttaggtg ttatcttagt gatatctatt aaagatagga atatagtctc agctatatttt 92820 gctattgtag tttttattat aatgagtata cttatatccg cttcagtact acgtatgtta 92880 ggtatgtaat ttaaaaagga ttaaataagg agggttagag atggaaaaac tacaagtatt 92940 aaataaggta ttagaaaaca ggttaggcat aaaagcgttt acgtattctc attatagtaa 93000 gcatacagt aacggatata tttacagttt tcatatgaaa aaagaatctt ttacttgtca 93060 tattgttgta tatgatgtta gttgtgaagg tttagataca tattagagtaa aagtactaga 93120 caggaatgat aagtaaatg ttcaacttt atatacttta atagaagta tgtatgatat 93180 actactatat gatatagata agtacctaa agaxaagaa catcaaatg aaatttactc 93240 tatgtttgat aacaattag atactattta agaagaggtt ttctctagg gaaaagtagt 93300 aaagtaa ataggctt gaacccgcat tctatggttg acatttaggt aaattagat 93360 aggttttccc tagagaaaa gtttaaaagg taaaaagga gttggttact atgtcaaat 93420 tagctagtt tgtagtt tgtagt tagcgcat tgtgagt tagctagt 93480 atgagatgta cttaggtagg ggttataag taaggtgtag agtaggtaat agccttattt 93540 atgttcttgt ataataagac aaccatatca ttgctaggtt tgaggaagcg gataatag 93600 tattccttt gagtgatacg cttgaggtgg ggacaattaa agacttagag gagtagag 93660 agttgtataa taatatctat acattattag gggtattata tacagaatat gaaataaag 93720 ttatgtatga gtatgggagg ttagaataat ggatattacg gtaagtgagt tatttgagta 93780 tatattaggt cattatacct ttagtagtgg ggattggtat acttatgact taggtgaagg 93840 ttactgtatt aaatttaatg atgggtattg taggagcatg cattttatca aaggtactag 93900 agtagtaaaa gaggttctta tcgatgataa acagctcttt aaagggttta gtagtattta 93960 tgattttatt gattactgtg aggaagcttt agatgaaaag tgcagaaaag aaaaagagcg 94020 cctaaaggaa attcgtacgt tcttaggtaa gtagagtatt atttattatg tataaccgct 94080 tctatatgaa actttatacc tatagttat atacctagaa ttattatacc tatagttat 94140 atactatag ttattatacc tatagttat ataactacag gtatttttt atatttctta 94200 cataaatgtg ttgattttat gtgtgttaag gtttatactt aatatataat taaaggagtg 94260 aagttaatat ggatatgaat aaagaagtat tagaacgttt agatagttta ggtggtaagt 94320 tagagcaagc aggtacacat ggttatgaat ccttaattaa atacacagtt actcaaggta 94380 ttagattt atgttcaata agtatattat tatctataac agctatctta tgggtggctt 94440 tgtataagtc agataaaaag tctaatgaag gtcatagtac cttattattt gagtttgttt 94500 gtaagaatga aaaagagctt tctgctgcag gatgcatagt attatattt gctgttacta 94560 tgtcttattat ttctttttta gtgctattaa taggcttgcc tattgctatt caagagattt 94620 ttaatccaga aggatatttg attaagagta cgatagataa tttaaaataa ttgtaaaaat 94680 aaggaggaaa atataatgtt agaacaagct aaaggtataa ctacagatta tattatggaa 94740 tttattgatg aacatgagca ttattcctat gaagacttac acaagttagc aggggagtta 94800 gtgttaaaag atacacatga cacaaaccct attgttatta atgatggaga tggttactca 94860 ggtactatta tatctaaatt taaatcaaag gtagagggtg ttccagatat cactgttagt 94920 gattttacg gttcatgttc tttctgtgat actttatcta atatctatga aggtagtgat 94980 gaacttgaga taattagaga tttagctact atggtactac atacaattca atctatggaa 95040 gagcaagtag aataatgtat aagggagtgg tatagtgttt agtaagagaa aagaaattaa 95100 agagtataag aaacaggtt actctgttga gtatatagga agtattttag gtttatttgg 95160 tattggcgat gttttatact atgtagaac taattagaaa tacttaagt cattagcgt 95220 aggtaagat gataccaat atgtatatga ctttaatggt tatgaatact tatcagaca 95280 taagttaat atcaagaag aagaactaat gtctaaagct attgctcagt tagtatca 95340 agttttaag attttaatg gagttaagca taatgggat gtaggttttct tagagcaatc 95400 ttttaatgta catcgtaaag ctattgatat ggttaaactt aaactaagtt ttgatgaagc 95460 gggtaccta tattatgaat taggattagg ttggattaat atttataag agtatacagg 95520 tgtaaaagac tttcttaata cagtagataa ctatctcaac ttctctata aagatatagt 95580 cactagtggt cttgaattaa aacaagtact atatatact tttattggag gagatttaga 95640 gtttgtagta tctccatata aggttgaagt atagagaa gctgagttaa ttgatgtaag 95700 agattttaat tatagcttct gggaatatgg gtacggcact atgtacata aacctttaca 95760 aaaaattaag tattactgg ataccctat gatgagtt gattaatt aagtataggt 95820 gtatgataga taddaaga ttaaggaga atagataatg agtagtaca aaaatagca 95880 gaaagtta ttgagaaattt tttagatgag actaataag gtgtagattt tactaatca 95940 gagaattta accgcttctt agatataca gagacttgt atgaattc tgaaactca 96000 agataaga ttattaatg tttacaaac attgtagtta ctgtatttat ggataggat 96060 aaataag gagaatac aatgaaaaaaaaagaaaatagtaca agaggtag 96120 aaaaagaag aaactatgag gggaacgat tctgttgtaa tcaaaaaat tcaaaaata 96180 acaggtgggg ctattcttcc tttatccaat ggcaaggaat atgtagtagt gtttagtaaa 96240 gtagacccta ctaaattaat tgtatttaat gtggaaaata atcaatcta tttaagtggc 96300 tctggtttcg atagtgaact gtcttatgta gataaaa gcaaccctat taccttagaa 96360 acagttaggt taatcacta tttattgta tattatttt gaagcgggta acagtccgct 96420 tcttttttta atagtagt tgacagtat attagtatgg ttatactta gtatataag 96480 attaaaggag ttggttatta tgaaaacaat tacacaagaa gaattagata aagtattaaa 96540 agaacataaa ttatggctga acagtgatgg cgtagaagga actagagcaa atttaagtta 96600 cactatgttg agacatgtta atctaagagg cgctgattta agaagagcta ttctccgtaa 96660 agctgactta agtcatgctt acttaacagg ggctatctta agagaagttg atttggatgg 96720 tgctatttta agtcatattg atttaagtaa cgcggattta acacacgcca gcttaaaata 96780 tgttgatta agatacgctg atttaagcta tgctatttta tcagctacag atttaagtag 96840 tgctgatttg agattttctt atttagataa tgctatttta aagtttacta atctaagccg 96900 agcaagtata acaggagtta taggactgaa tatttactct atagataata ttggaacttt 96960 taatggtaag gtaacttata ttcctagttt agacactgta tttgcaggat gttggaatgg 97020 aaatttagaa gcgttttag aaaaaggttt agaaatgaat gaaggaaaag aagcggacaa 97080 gattaaaaaa gcatatgaat ttttaaagt gtgtacagat taaagattat taggctttta 97140 aagattaagt tattttag gataaatact actagaaaat gattaccgtt tattacagaa 97200 ttttaacgta cctagtttag aggtcttaaa tataaaggag ggtattagaa tggctaagt 97260 tgtaagtaga ggatatagtt ttgagacaca agagtaagt atgaattata accaagggca 97320 atggattatt tacgcaagta ggaaacctta tattaccgat atttagaaa atatccgga 97380 taaggtagaa gtactagagc aactagataa tgtacacct gtactcgtta aagttatatt 97440 naggaggt tattacgt tagaaaacc tgtagtaac gagcgtaag aaaaaatgaa 97500 aaagattgct aaagaagat ttggtaaata attaatata ctagtgaga agatctgac 97560 attaataac accaacgtga taccgtaca cttgtaggaa ctagactaat gttacagat 97620 atctagtag gttatggtct tattgagaat gagtagctt taactaact agttaaagaa 97680 gataaacagt atttacaata tcatatcgaa gaagtagaag cggtattaaa ccgcttcttt 97740 tttatacatt atttacattc tgagtaata tactgtattt aatctttggct ataattgta 97800 tatcaatttg agcatagtat gcccgtttca acatagttaa tctaataatt tatattatta 97860 tctgttagtt atgtataaat atttgttatt acttatttat atatttgtat ttcgtactaa 97920 ccgtacgact tatcttta aaagataag aaaaacag cgtatacctt gttgttttac 97980 gctacgctac aaaagtaa cgcctgtaat aagttattcg tattaaata ctaacaacta 98040 attacktgtt gtttagatta tacatatgt tatgagaat taggagaa tttagttaca 98100 acagcattat ataatatta cagttatgtt acagttgct aagtagttt tgttactaca 98160 atatattgaa tatgaaaact ttagaccttt tctgcagaca agtatatt acaggtagt 98220 atgataaag gtaagtaca gggattaat taggttgga ttaatgaagc ggataagtta 98280 gatactgatt aaaaaaat actttacatt acctaaaact tatgatacac ttaggatagg 98340 aaagggg aattcaatg aaaaagg aaaaagg gatgattac 98400 tttatacagt aagtctttgt gagggaacag aagaagattt actagaactt attgagaatt 98460 tattttatat ttacaatgac gagcctgcat tttaagtaa agacggtatg caatacta 98520 ttaaagagtt tattggagaga agaaaaacat taggacctat cttaactgaa taggtatag 98580 ggtacgcaat gatagaata aacacacata cagaatacga gttagttact cattcagtac 98640 ttaaagttat acagtatgat gtagataact atactgtaat tattgatact atagtgata 98700 agatattaa gttatcagat ttacattag aagctgttaa ggacattttg atcaatta 98760 agtagctagg gttgtttta ccctagcttt tttatatgct tgtattgcct atttaactac 98820 attatatag caagtaagta attattaggatta atattacct aaaagtatt accgttgaat 98880 atagacctat agattaagg ctctcttact gttataaca tcataagtat aaatctatga 98940 tttcctaag tagcaggcgc tgttttact aaaaatgta atatcgtaa gtatcaggcg 99000 ctgttttccc tttatattaa ccgctcaaa caacataaa aagattagg ttaatagcct 99060 aatctataac tctttatat aattcttgta attctttc taacttttt attgtttcta 99120 tatcattatt tctttaata gactgacata taaatgcaat acctttaatc aaattaaatg 99180 gttagtttta cactgcattg tatacatta aatcgattga tattaataat taatttaagc 99240 tgtactttct agttctctct atataatggt aagaaaacat ttatttaaa aacttcgta 99300 taacctattg acattaata caagatactg taatatata agcgtagtaaaaccgaa 99360 aggaattgat aggatatga cgtaataa attgggata tacttgtaga acttttagac 99420 atggacggtt aaaagca taactactat agaaatgact taaaatactc tacacattat 99480 caatttaat atttagctta cattgatgat agctatgaaa cattagaac atttaagaa 99540 acgaaagtct ttagcgtac acatcaat aggttaccaa tattaagta 99600 gtaaacaaac acttattt agagctagat atacgttat acctagtgaa cgagaatgca 99660 gaaattatta aagaaaaaaa gttaaaata tagttgacac tegattaat atagtgtaat 99720 atataggtg tatachaat aaactaaag gattgatta ctatgaaac attackattact 99780 atagtaagc cgtatagaa ctacggctat gaatggaac attcgagag agaaacaac 99840 gttattatca cacgagcata ccacgaacca aaaacaag gctatgacct tgtagtacat 99900 tatacggagg ttaatata tgaatacgt agactacatt agaggcacgt acacagaat 99960 taaagcacaa ggatatatta cgaataattg tagtttgtgg tctgatatgg atgaatgtga 100020 cgacttatat tactatatca ataaagcttg ttttaactta tacggtcaag gcgtacaagc 100080 ataacaa acggccaaat gtgttaaaat gatacttaat gacggtcaa caagttttgt 100140 taaaaaaggt taaaaatg ttaacatta cacttagat actgtaat atagatta 100200 gtaaaaaaac aaatcaaaa gggattgata cacatgatta aatttaaata taacggcaag 100260 aaataccgtt cacacaaa gagatgct attgtaacta ttaggtgg tacagcagta 100320 atcacattga tagactggtt tattagatta tattatatta tattaata 100380 gggttaacca cccttatttt ttttgtgct tatataccg cttcacatta gtgtaaaact 100440 tcccttattt ctttgctaaa atactttaca atatgagct tatactgtaa tataaagt 100500 gtagtaaga acacgacaga gacactaa aaacttaa aaagttttaa aaagtgttg 100560 acatacat tattagtg tattata tagtagta aaaaaaaaaaagg 100620 aattgatta tttgaaaa tacagtaaaa gaatggcaa acggaacac taaacttgaa 100680 agattattag tttagcaat tgaggaagcg gttatgacag agcttgttga atatgatgca 100740 ttagataat slow speed ttack speed slow speed 100800 gaacgtaaac catctaacat tgactatagc acttacgagg gggctatatt agcacagac 100860 aaagcagaac actttacta cgttatctta aaccacatga aagaaca atttgaaca 100920 atgatttgg atattgaac actagaattt aatgcagac aaatgctatt ctaggagac 100980 attacacatg aacttatctg agaagaact tatagatata atggacacg ttatagctt 101040 cactggtatt agggagcta ttacgaat ggaaaaaaaaggcta agggagtga 101100 frequency xgaxatta agaatata tgttt xxxxx agaxatta 101160 cataacaca ttagcaccag atgtaataa agaattactg aaatcatt agtgtaaac 101220 ttcccaaaat attaactaa aactattgca attaactgta gatttgatat aatgtaatta 101280 aggaaaaaca aataaaagaa aaaggattga taaactatga aattacttaa ccaaatgaaa 101340 caaacagcag aacttgaagg aattgaattt gacttattat taacagctat ctatgaaaca 101400 atagaggtag aagctgttga acatgatta ctatgtaaat acattcatat tgtaaaccaa 101460 ttaaaagaga ataaagacat aacaccatta gaatatatac cttctaacct agactttaca 101520 gacaatacaa caataagact agttgataat aaagtgtttg agttagcaga ttatataatt 101580 gaacatatga gtgttaaaga gtttagtaaa cacattaaag actatgaaca aattaaagca 101640 aaagctatag aaatgatgta aaacaaattg aaagggaata aactcccttt ctttttttta 101700 ttattaatta ggattgtata caataggtta atataaatat attacggg ggcaggggta 101760 aaatgccact aaagtgggtg ggtcttacag ggctataggg ctacctaagg aacctaatta 101820 gtgagtaata ttatataact tattattaaa agtcaacatt aaccattact ttattaaact 101880 atgtcacat tactaataac taattgtatt cattttacaa taaagttagt atatgttttc 101940 cttactctct tacacttaat tagtatta gtatattacg acatagt agtttagt 102000 ataggagcct ttccttatat atagttttct atggtattct atggtattct ttagtatacc 102060 attttaataa ctatttatgt agataccat cagttagtat gggatattac attackattatt 102120 attaaaagtc aacattaata agtacagtgt actaaaaagt cacatagta ttattacta 102180 taaagtcaac ataataggat ttccattatt gttcttattg tcctacctat ccctattgaa 102240 ttactagcag tagtgttact ctattctta caataaaaacacctata gtataata 102300 ggtgtttaat gtgaggtatc attackactac tcaacatt ctttattac ttgttcgaaa 102360 cctttctttt tatcttttat atatagtta ccgcgtacaa ctttctcaat acctgaaggt 102420 gttttaataa acaggctatt gtctccttgt ttactactg ctctaaatgt tgaccttct 102480 gtccactgat taataacatg cttattatat cctgtatatt gatatactc tactacgtct 102540 tccatatcga ttagacttt tagcatatac tctcttactt tagcataatc atctgtagtg 102600 gtatctaagt ctaatggttt taatttgct atattgctta tattacgttc tcttacaggt 102660 gtttttgaat attctaccat taaatctagt aattctcac ttgcaccta actcctaaaa 102720 gatatttgtt cgttgagaaa cacccaagca ataggttgtt ggttttcttt tttaatagt 102780 atttttcttt ttctcttggt agtattttta ttgctagg taacagtata ttctactgt 102840 tttacatttt cataaattc atttgtatac ataggtgta cttcctttgt tttattatta 102900 tccactatgt ctatttcatg gattgtaatc atgtcatctc tatactcatc tatatgctta 102960 aggtaactga cgccatcatg tttttagac attccttgta attctctata tccttcggct 103020 ttaatatctt taacaagctg ttcttgtta gtgtatactt tatctctct atatgagtag 103080 ctatcctcat aaggctcaca atagtcatgt tctacttgat atagtttcat attattttta 103140 ctcctttta atttttactt ctaattctgg taatacatttt ttgaaatat attatta 103200 gtcatttatt gttttaactc tataagtacg catgtttctg ttactaatat ataaattata 103260 taaatcctct accttacttt caataata gaaaggatag cttatacaac tcattaatag 103320 agatatacta tacagtatat tttcaggtaa ttctctagta aatttttaa ttttattac 103380 ccttttttct cttcttaatt tttatatag ctttcttagg ttgtgctcat gttttttaat 103440 tacaagtagt tgatttggt tagtaagct atcgtcgttt ttgtttatat agtttaatat 103500 tccttatat aaagttagta attctctatc atccatatta atattatctc cttatgttct 103560 acatttaacc agactaaagt ataaatgact tgaggctcta tatctcattt attctatgtc 103620 cttcttttac tgattggttc catgatttta gtttttcaaa gaacttggag tctactttac 103680 cttctaattt ttggttagta taatcatcat agaaactaaa tgttccgcct ttaaaaaagc 103740 aataacgt gtctgtcgta tagttaatat taatgtactc tatatagtct tttgttactt 103800 ctggtttgtc ataacgtaag actggtattt cttgacgtaa caattttatt ccttctttac 103860 ttaaaacctgt atatcttttt agcttgaaac cgaacctcaa ccaaaagtct atttcattga 103920 ggttaaaagg ttcatttact tttttaccta aaatactatg cataaatagc atataaacaa 103980 gttctatata ctctatacat gttgttaaaa aatgttgttt gtcttcaaag tgatggtaag 104040 ccaacaaata caaaaacgta aaagggaaaa gaacaatgga cattaaaaaa tataaaaatg 104100 attttaatct tgtgttcatt actcagacac cttctctaca tcatatagta ttgggtatag 104160 attgaagata tgaactctat atccaatagt tttaactttt actttatctc ctacttttaa 104220 tctagcttgt atgtctgcgc tatcaaactt tcttttgaag aataagtctg agttttcaat 104280 gacttgtttg ttgtctaata caatatagaa cttgtcttct ttatcttgtc ttttgttata 104340 tttatctgta attgttcctt ggtgcgtttc tttgtgttga tagctagcca ctgtatagat 104400 aggtaagtg ataacaagta gcaatacggt tataccgaat aatgacagta ttccaaaaat 104460 aaagatatcg aaccaattca tatttttaag ttttttaatc attgttacag caatctccca 104520 tcttcccaaa ttagtcttaa cttactttga tgcataatat agaagcgctc agatttacta 104580 gatttaactt catttattga catattatga tgagtgagta tattttcgtt atctagatac 104640 tcgtatagct tagtaaatac catgtcttcg gtatagtcaa taactgatag ctctttgatt 104700 aaaacatggt cttccttata atcatttata tttttgtaat acccatatcc ccttactgca 104760 tcccataccc tttcgtaccc ttggtctaaa agtgagttta ctacttgttc tttatcccta 104820 tagacttttg tttctgtata tgtttcttga tattcacgag gtttacaatt atcatgttct 104880 agttgataca gtttcatagc taccccatcc tttccaataa gtatggattt tcatatatat 104940 ttcctttaac ttgtaactct aaagtatctg tgtatggttt tatggagaaa tcactaagta 105000 aagtaagttt acaccctgca tacctcacta tatagaaaaa tcccttaccc ttcttaatta 105060 aacctaggtc actataatta cctttggtat ttagtatttc tataatatct ccttcatata 105120 tatcattacc gtttacatct ttaacttctg tgctttgcat aatttcaagg ttttctccta 105180 aataaccttc acaagcaaat agatgtgaat atactgtgta atctgcaaaa tcaaatctat 105240 caatattaaa cattctttgt gattcttcat cccatgctct aaatttcaac atcatactac 105300 ctccactttt tcgatttcta tgcttacagt tttgaatagg ggcttttac gagtcagttt 105360 taatgccata ttcttagctt cttcctcatt tatactttgc acaaaataat gcttttttat 105420 tttgtaatca catttagata ctaagaactt gatacaaaga cttactttat aggtttgcat 105480 cattctacca actcccccatc tttccaaatc aatgtcatcg tcatgtcatc gtttaagata 105540 tagaatgctt tggtagggaa agacgcgttc tctaaacgtt ctttgatact ggtattgtgt 105600 gcagcgctga catataggct ctttctcgaa actcatatac ttcaaacaac ctatcaaact 105660 tagtatcttc tgtgatttcc tcttcaactt tgacttcgaa aagagtatcg atagaaataa 105720 aacctcctag agtaaaacat ttatttgtat ctttttgaaa acataccgct tcataacttt 105780 cacctgttgt acaatatttt ttgccttgtg atagctctgg attttctcta gcccatttaa 105840 ttaactcgtc taatggcatt tcttttttag ttttgatttt catttccata tctcctaatt 105900 atttaattt tctatcattt tcacaatctt ttttgattct ctaatgtcag cttctcaca 105960 gttttttaat atgaaattaa ttttgttttt tacaacatta acgataatgt ccacttcttt 106020 ttctgttggc tcggtaggga aaagcaaccc tacaactatc tgaatttgat ttttatttag 106080 tgagtaaaca ctaatgttac atttctcatt aaagtcaata tgtggtttac ttgaattaaa 106140 tacctcatct acaattgtat ttaattcttg gataggttta aaataatgtt gttttctttg 106200 tatcattacc tgtgacatta gtttatatag tttctgttct tttcaagca tttctttgtgt 106260 aagtcttta acttccccta tctttatagt attacctcgt gcatcataat tatttttaat 106320 atactcagct tcttctatgt tagtagtata tcctattact tctgaggtgg gttcctcatc 106380 gtagtaacag tcctcttcta catatatagc atatatctta ttcatatcta tcaaaccttt 106440 ctttaagtta aattaactat aacatataag cattagggtg tcaactacta atatacactt 106500 tttacagtaa aaaaaaaa gaacctttt acaggttctt tactaggtta ttaatttttt 106560 aaatcttgat ttccttttat tagctttta tcatcaatag gatgaccatt gtataaatat 106620 tttactcca tatatacatg attatccgta gccgtaaggg catctaggat atccggattt 106680 gtgttaattg catttgtatc aggaaacgaa aattttctt tatcagactg gattgtatct 106740 acatgaaattt ttctctgttt tggtaaag taatttaagt cttctaaattt ttgtaggaat 106800 tttagtagag aaagggttt gaactttcct tgtaattat tatctatata atcatttaat 106860 agtcttgtca tttcctctt atttaaagtc attgttcat aatcgttaac atcataaaaa 106920 aacaatat taggttgctc atacttgta tctccatctt tgtacttagc aatgtaatag 106980 cctatttcac ctttatgagc taaataatct tcttcatga tattaatac ttcttagca 107040 ataggttttg tatatagttc ttcccattca ttgttttctg tgttgtaaaa atgtggtaat 107100 aagtttgcca ttatagttta tcctttctta ttccgattta agccatattt tgttagtgtc 107160 tttaggtggt tcattgctga ttgtgtaccc gtcggtaccc atatctaatg tgttaacaat 107220 gacaggctga gctacagctt ctttttcact ctctaatgtt ttgaaactag gcacatctgt 107280 tttattagat tcttgtccat cgactaacca agagacttta aagtcacctt tattataagt 107340 agtattaggt tttaaatctg ttaatgttac ttttactgtg ctacctgtaa cttcatcaga 107400 agttaaaata agctgttcct ctttgttgta gacctttaat ttttagtca taatgttatc 107460 cctttctgtt gtgtaataca ctaataatat agcatataaa aaacaggtaa gggctttcaa 107520 aacctttacc tgcttattct ttactgataa tcataccaat caagaaaatc atctgaacag 107580 cttaactcta tagttatatc atttataagt tcagtagctt catctttact taatgactct 107640 atatcaaaag taaactcatc atataaacaa tctatatgct tataaataaa atatttttgt 107700 ttttccgtag ctttgtttaa ctcattgctt ttttactta taaattgact aaagttatca 107760 ctcatttaaa tcttcctct tataaaggt accattaact gtttttcctt tacgaccttt 107820 aatttcaccg taagcaaact ctaaacactc ttgtaatgac atgtcgtgtt gctgagctaa 107880 aataattaaa gtaactacag tgtccccaat accatcttta agagcttcta ggttaccacg 107940 tgataatgcc gatgctactt cacctgcttc ttcgtagaat ttaagagctt gtctatcagg 108000 gttgttattg ttcaatcctt tatctttact ccattcctct acttgactaa ttaaaccttc 108060 tagcgtgcgg tcttctgttt caccttcatt aaagttaggt ttttcatcat ttggtacatg 108120 ttcttcttgt tctctatcct ctattgtaat aaataaagtg tctatttctt tttcgtactt 108180 atttctctgc atataattat actgcccata ctcaggataa ggtacatata cagtatcgtc 108240 tgtaccatcc tcataattca aacaaacaca aacaatatct ttgccactta atctatcata 108300 taatgtcatg ttgtagggct catctaagaa accatgaaac tcttcaaagt attcatcctt 108360 cataccactt acctcaatag aaactttttt tgctgactta cttgtatcta cttcactatt 108420 tccatatatc atagtttttt cttcactaat accttctagt atcaactcta cattttctgg 108480 ttctaacacc gcactatcta agttttcaaa aacaatttca atatttttaa tttttttagt 108540 cattaataat cattcctttt ttttagtata tagtaaatat aacacataag taaatagaag 108600 tcaataaaaa aaaacaccta ctttaaaaat aggtaggtgt aagatatttt agtaggtatc 108660 ttgtggaaaa aaatcctgag caggactcg aacccctcga ctaggtagct acaactagcc 108720 aatgccatta ctcaggattg ctagtaacgc taaatagggt cataacgtta ccgtagacct 108780 tttctacgat ggtagatagg tagaataataa tgatttcaca gtacccatat ggtatagctg 108840 ttactctcat tataaggtta aaaaatgcta actgtgtttc gcattgttaa gaggcgttag 108900 ttaactacta taataatata gcatatattt tattgtttgt caagttcttt attccattta 108960 cttttttctt ttagtaatcc ttttttaatt aattcttcac taatattttt atactcttta 109020 ttttctttgt agaacacttt agctaaatat ctaccaaaag aatcatcttt gtatgtttga 109080 attaaaacat cttttcctt taacatagtt gttgtaaatt ctttagcttc ttggtaatta 109140 ttttgtttct tttctggtgt gtcgacacct agtaatctta ttctttgttc agtaatgtt ctcattccgt ggtcaatagt tacatgtata gtatccccat ccactacttt gtccacgtgt gctttaata father gtcttctatc atcattaat ccccttttta ctaatttaa attack cagtattgct tgatgtacct ttagctacat attack gcctattata gcaatttgac ctttgtata aggtatatta ctaatgcttt cagttacacc tatttggctt atgacttcaa aattagcttt tgtggatata aattcccaca gtatagagcc atctgatata acaccgttat tatgagtagg ttgtgttcca ccacttgtac ctgaagctac tgctttatat acataattcc cattataac aatttgacct tgtgtataat ccgtattaga tgtccacttc atattagtag caactccatc gctagtacat ctccatttct caggactacc tgatgttagg gttctactag father aattctccc aatctccaac ttcctgtagt tggtattgca gtaccgttca gtactttagg 109800 gtaccgttca gtactttagg gcattactag aaatacttaa gttttattc atattgttat ttatacgaa tagattacta 109860 caagaacctt gaacactta tgaatcatta cctttatctg ttttatatc attattagta 109920 attgtactat ccataacaa atttagaac atagcttat ccaagcagt atttgtactt 109980 cttaatgtat tattttaaa gttaatttct gandacaggtt tactagttgt tcctgaaaca 110040 taaataac ttgtttta acttgttgta tcttgtttta atacattatt ttgtatatct 110100 atgttattaa ctcctggata aaggtacaac tcgtaccct cattacctga tacattattg 110160 ttactaataa ttcctttact acctcctgta atagcaatac cattagatgg tttattactt 110220 aactctcctt tattactatt accataatt acgttattag taattgtata attagtacct 110280 gatatactca gtcctgagta cttattgttt gtagtagt tattactt addaacattt 110340 tctgttcctg attcaaacc gcttgaacca ttccctg atacattatt aacatagtaa 110400 ccatttttag tgccaccat aaagttaaaa ccattctcta aacattgtgt agctgagcaa 110460 ctatctatag taatgttgtc tgagtaatca taaacaccat ctaccgcttg catagtgttt 110520 actgcattta caacgttacc cataatatta taaccatgta cattatatgc tttacagttt 110580 ctacttcctt taaatgctat tccaatagaa cgaggtgacg catatctaaa ttcaccttta 110640 ccatcccatt cccctttaaa tgttaatcct tctacaagaa tgttatcaca gttgataaat 110700 gagaatcctg taaacatatc tctaccacta gaagaaacat catctataga gtctagatag 110760 ttttagtga ttcctgacat aataaatgta ggattacctt cacctttaat gtatattatta 110820 cttcctgtta cttttacacg tgatgggttt tgtacagtag gtgttttagt tttgaataaa 110880 tagtcctctg ttcctttagg tactataaga gttccaccct tagtacttat taaataatct 110940 aaagctcttt ggaatctagg gtaatcatta tcttcatcat taattcttgg gtaatcttct 111000 atattaatta ttactttact cttagaatta gtatctttac ctagttcttt ccaatcatta 111060 ccttttagta cccaaccata tgcttgtgtt gtaccattgt tgtatacctt ttcatcatat 111120 ttaaaatctt caacactaga aggtttaaca tgagaataaa aaacatcagt tttattctta 111180 ctactatcgt ttgaagactt aataatatta gatggattag ttgaagctac aagtaaacct 111240 tgcatagttc cagatattaa aataacgata gacttaacat cttcactatt aacagtaaaa 111300 gtatcttttt gggtgttatt gaaagtgaac gctttatatt tatcgttata ataaccatcc 111360 agtaatattg tatcataatt attagatatt ttgtctaata tattaccgtc tttatcaaaa 111420 catttaataa atataccact agaattacct ataatgata acttgttaat attaactcg 111480 tcaccaacac taacattatt aacatataaa gccatagggt acgagcctgt aaaggtaagt 111540 aatcctttat tatctactaa actaggtgta gtactgtagt cataagatac ttcatctgtt 111600 agagaagttg actgtaatgg ttttctaaat acatttttga ctgtgtgata gttacctcct 111660 aatcttctat agtctttgct aaaatcatta ttttataca ataatgttgt tttgtattcg 111720 tctactattt tagcaatact acttctaggt attttagcag tattaatatt tgtaaacgtt 111780 agtttatgtc cattacctaa aacaaattca ggaataaact taatatcttt actatgtgtt 111840 acataagatt ttgtcatatc ttgagtttct aaatcaacaa ccgcaaaagt agctttgtta 111900 ttaaattcaa atctgtaatt cttaaatata aatcctactg ctttcttaag ataaaccata 111960 acataatttt cagatgttgt ggaagcagtt tcaaatttaa gtgaatcgaa tacattgcta 112020 tttcctccat aggtattacc atttgttaga gtttgtttga tgttatagta tgtgttaggg 112080 tgtttattaa actcagtgcc actatatgaa aaagctgatt tatagaagta attactattc 112140 atccaagatt gctcaccatt agaatctata ccatctgtat ttaattctat atgtgtttca 112200 ttattaataa agaaattaat aatagtatta ttaaaccaat gacctctacc accagtagct 112260 ttatgtttat tacctactgt aaaaccaata atttcattaa tattagtatt aacatttcta 112320 cagttaacta attctagtcc tatatagttt tgactcttaa aaccatgata gcctccacca 112380 taagttggat aagaactatc atcataaata cctttaattg taacattaga atatgataaa 112440 ctatctagtt tatagctgg tttatcctta ctaccattat aaacaatctt agcatcagat 112500 acaatattaa tattcttatc tattatcaaa gtatcatcta ttttaatagg tgattcacta 112560 gaaggaatgt gtagggtatt accttcactt gtatctttaa tagcacgtct taaccttga 112620 acatccgaag tatcatcttt ttgctttata tactcgttag agtatacata aggactttta 112680 cctgttttaa gccaatctgt agctgaacct gtaaaaccgt tatttacagc tacttcataa 112740 gcacttaaac cttgcttacc ttgttcccct ttctcccctt tttctccttt atagactta 112800 acccattctt cttcagaacc gacaaaacca ttatctactg ctacatcata agcagattta 112860 gcatttacaa gtatatgatc tttaaaatat aatgttattt ctttgaatga tgattctagg 112920 gttgtaaaac caggaactac tactttatcg gtttcatatt ttcagcttc ccatgataca 112980 tagaactcac cttgagggta atgtgtgtga ggagctaagt taggtatgat tacagaccct 113040 acttcttcat gtaactctac attgtaacct attgccaata tattaccgta tttatcatat 113100 gcttttaaat gaggcattga aaatctcctt tgctattagt caatgttaat atatcataa 113160 acacaaaaaa gggcaattg ccctttagtt acagatatca tttagatgaa tatggtcttg 113220 tactgaatag tctacaatga catgtgtatg ctttttcttt tttgttaaca ctttatatgt 113280 gataaagaat gatacaatag ttaaacatat atttaattt ttcataaaat ttctccttta 113340 aagaaagtat ttaccatctc agtagttaat tcttgctt windowataca agatctctgta 113400 ttgttattca atatttctaa catattttgc attackacttg ctttttgtaa atccgttaag 113460 tctatacaa ctgttatttc tgcgttatct attagaata tacctagta ataattttta 113520 actccgttct ccgtagcatg agaggtgaca ttatgattta aaacaactat accttttgat 113580 ggtaagtaat ctgaaagta taggtaaca aagtatttat gtatcttttt tttattctct 113640 tccattacta ttaccatatt ctagaagtt taacaacctt tcggtatagg ttttaattt 113700 ctctacttct tttctttcat cgtctttct tcctaatctt gttgtatatt taacaatatt 113760 aatagcatg cagtctataa agccaataat gtagaaatat tcttctaaaa atgatataac 113820 atctttttg cctttataat ggtttggtgt attagtggta gaattgacat tatagtataa 113880 ctctagttgt tctacatttc tcataagctt tttagcataa tataatgtgt catctaaaga 113940 atgtgtcaca tctaaagatg attcaataat gtttatcttt agttctttta attctgttgc 114000 ctctttgtta cttccaattt gtgagtcaat aaattctcta gtatccatat tggtgtcctt 114060 tcgtatctaa aataaaacc ctatctagaa tatagatagg gaaaaggaaa gatattatgg 114120 aagtgtacta taaagtacac atataatata acagttcctt tgccttttaa tctatatcat 114180 ttattttaac ttcttgtact ttaacataat ctgataaact attaacgacg atattatctt 114240 ctactaattc gtttctatta tttgtaacat catatgagtc tctataaggt gtttgtacta 114300 atgctctaac tgtaatgtct atatctacat attctttact atacctttcc attactcaac 114360 gtagttcct ttagcaagct gatacttttt gtgtaattct tcatataatt tctccatatc 114420 tttatatttt cgtacatctt cttcaaatg acttaaatac tctattaatg tcttaacttc 114480 tttaggttct aaagttataa ctggttttac cattacgcaa catcctcact aaattgttta 114540 tttatatttt taatatcttt tattaattcg tctttaatt ctttaggtaa ctcatgactt 114600 tttaaagatt gttgttgacc taacgtatat ccatatttg ttacttac ttctacagta 114660 taccatgatt ttctaatc gtcaactttt ctagctagta atattaaca tctgtcattt 114720 ataatattcg aagcatact gccgacacaa tgagatagct gttcaccttc tctttttaat 114780 ttttcagtag tatccgcagg taaaaattta actttagagc catcgttta cttatattct 114840 ttatttgtga tattatta tttattatca tattttgtt gtaacttaa gtcatcgact 114900 tcatctttaa ctgttaaata ctcatcagta acaatcat gcttagtttt windows 114960 ggtgttaagt taatactttc tttagttcta tatchcagaa gtactaggtc tgagcaag 115020 tctatatat ctctataata attattaca gcgtatgaat gtatacgttg tctgtttctg 115080 acatcatagt ttatataatt caccattttt ctaaagtcag aaaatgaaaa gttaagaact 115140 tctttcgtag tacctttaaa agataaagca tttcctattg aatatgaatt agtcaccatt 115200 ataaagtcgt catcgaatag tttgtgtaag ttagactcat tatataaact aggaaattta 115260 tttatgataa ctcgaagtat attaaggtaa ttttcttgct cttctttact aagagtaata 115320 aacttattat atgtttgttt acttaaattt aaagcttcat gtaatttcca tttatttttg 115380 tttggtatta ctagaaactc tttgtgttct ttaaatatat cacaatcttc gttgttataa 115440 actttatcaa tattagacac aactaatttt aacagattgt ttaaattatc agtagcattt 115500 tcacctttac taactgtgcg ataaccatca ggtctatcta tcatagagta tacatcaaag 115560 ttttttacat taagtctact tagatttaag taataatcat tattctttag tgtttggatt 115620 attatgttaa aagctaaatt ttcctttcca tatttactta aaataatatt taaaaggaca 115680 ggtaaagtaa tgttatttt taatttatcc ttattaaaat catcttcata catattaaat 115740 ttaaattctt tatgttgtag tgtatttgat aggtgtaggt attackttcc atttttatta 115800 ttaaagtcac cgtttactat actccaatct gttgttacta tacttagtc ttttaaataa 115860 caagtcttaa ttaaaaacgg agtattatta tctttattag gtgttaattt gttaagccct 115920 atttttatat tttttaaaac ttcattgtag tattcgtagt tattatcata agatttacca 115980 aatgcataag ggtcaatatt ataccaaat attackatagt cacccattaa taatacatca 116040 agtatatcat tagttgtagt attattgt ctttttaaat ctcttatttt tttgtagg 116100 tagttattac tgctcttatt tgcatactg tcaattgtt tagttattac tagtactt 116160 gcacggcagt atatcttatt acgatagtgt cttttgttat aaaggaaa ttcagaccta 116220 tcgtcacttt ctatatactc actatataca gtatttacat ctgtaactgt tttacttaac 116280 tcttgtactt ttttatatgg gtctccctta aacgtagtaa gtttttt cccacataat 116340 gctataata aaagcaattt taaagcacta gaatacaa aggtattatt atatctctt 116400 aataattctt tagagccaat atctacaata tttttattat ttatttttaa atatactctt 116460 tcttcaccta taaatatact atttctattt actttagata atttaagaat ttcttcttca 116520 gttaatcctg tttctttata ttctactgac atgtgtcatc acctcattta ttattatata 116580 agtatggtaa catagttaaa cttaatagtc aacaaaaaag aagaactttt ttacagttct 116640 tctagatag tttcatattt aattttttta gttcttctta cgggtacaat atcgggatta 116700 ctcattaagt ctttgtactt cttagaattt ttaaagttaa tagtattagg cattgctaat 116760 acttctctcta actcatctgt gtacatagta actttagata ttatatctat gtcactaatg 116820 tataaatttt tagatttact tttaaaaata atctcatcgg tactagttac ttctttatta 116880 tctattaaat ccatatagaa gtcctttcta gtctacataa acaagtatac aatctttgtc 116940 tgataaagac accgaggtca tatcattaag ttcttgtagt tgtttaatag acacatcata 117000 tttcttactt atagtccata aggtatcacc atttctaacc ttataataga atttattacc 117060 tttttgtatt aagtctttca ttgttatcta cgcctttata ttcataataa gatgcctgta 117120 ggtaacatat cgtaataaga ataaagttag ctacttctgt atattaca tgtggtgtcg 117180 tattgttat atacatacta atattaac aagctaatgc atacctata atagaata 117240 atatttgct agttccattt gtactttag tttataaaa tttatttatt tgggataaat 117300 aagctacgat atactaata gtagccatta tctgtccata ttcaactg tagttagcta 117360 ctgaatagcc gataata acaataacat ttctaaaaga ctaacttctg 117420 ttgttctaaa taagtataata aaaaaaaa taatccctag taataacta atacttactg 117480 atataatttg aaataggggt gcatgtgtta caataagct tgttaagcta attacktactg 117540 taacacaat aaaaacca aaatagctat ctacacctttt aacattctta tcttttaca 117600 aacctactaa agcaggtata tatcctacag taactaat agcatatagg atgcttaata 117660 tatgagctaa attagacatt agatgcaccta aacttttcta attcccctaa aacttctcc 117720 catgaataa cacctttacc gtctgttaaa gataaagcta ctccgtatac gtaagcgtta 117780 aaagaatatg gaactctatc catatcatca tgcatatctg ttgtgttcca tctgatgtca 117840 ctagagtaaa ttaaaacagg tttatttagt attttctcgt taatttcaag ctctttatct 117900 aaaactgttg ctacatctgt taattcacca tttacatcaa ggtaataat atcatataag 117960 tcgtttagcc tgtcaatagt aatttgtgct tgtcttttca tttgaaaaat ttgacctaac 118020 tcggtgatgg ttcctaaacc tccattaccg ctaataggca aatcaataac ataaatatca 118080 gattcctcaa tagcacacgt gtcgttttct acaattcgtt ctgccaactt atgtgagtct 118140 gtattctttt tatcgttaaa tgattgtgag ctagggtcaa aaactttaat accaaata 118200 ctttccatct cttctttttg tttgattcta tattctttta acccttgcat caacatatcc 118260 gatgcatgat acacctgaag ttctttcatt aaatttgtca ttctacttct ccttttcttt 118320 ttcaaactca tcttttagtg tgatgatatc tttattcagt tcttctgagt ctttcatttt 118380 agcccaataa taaaaatctc taagttcagg gtttcttgtt aaaatatt gcttaggtct 118440 tacatctctt ctttgtgata aggagtaagc tatatctc atatatttcc agtctttgta 118500 atagtcagac ttatatta actaaatcc ttcaatct tcaatacat acccttcatg 118560 caatatta taagagccat tattatcctt ataccatta taaaattctt cccactagc 118620 aaactccaac tctttttctt ttagttgtaa tcctacttca tcagcacat atttcaaata 118680 atcataatct ttcttttca tatttaagt atttgaaata atcaagta agaatatatc 118740 gctttttcta tattttatga tatgtgggtc ttctcaata tcaactacct cgaacactag 118800 ggtaaaacta tcgtcagcaa tatatagtt ttcaggaat gttgctagta ttgtatttg 118860 tctttttggtt aaagttttt ctactaacctc ttataatagt agtgcatatt tatttccatg 118920 tccacttaaa tgggttttag atttacttgc atatataatt ccttctaacg ggtcatagaa 118980 cattagtcct aaaatccat tttctctt atatccagtt aaagggaatt ggatagtgtc 119040 tggcatattc tctaatttgg tttcttctac ttcattgata ttaaagaact tattatatcc 119100 tcttcctagt actgtgtttc tatcttcatc aataaaga cctctagaac tcactgttaa 119160 ttggttccat ttctttttag aaaaagctct ttttgtaaag ttaactgaga acacatctct 119220 atattgttga ttggttttga tggttttatt ttctttctg gctatatcta ggtattgatt 119280 aggagtgagg tctttgtcaa tactatcgtt ccgtctgttt gataaaagga atttagggtc 119340 gtaaatagtg ttttttactt catgcttctc aatactgttg tttttattta tcgttatagc 119400 tcttaagcaa ccaccttttt ctacacgacc ttctaaatta actgaatttt tagtagtatc 119460 taaaggctct ctatataaat tcctatgtcc atgtatttgt attgtattag aatgttccca 119520 ttggtcatca acattaaaat catatccccc gattccatta ataagctgac ttgttgaaat 119580 cttatttaaa tttcaagaa cttcaggaag gactccgcca tgattaacaa tgtagtcttg 119640 acctttaaaa ctaaagtaag ccacctgctg taactttcta agaatagact ttactctatt 119700 ttgagttat ccgttctcta tgaaggattt caaggtaggt ataaatcctc ttgcatgaaa 119760 tatttttaaa gcttgtttat aaaaatcttt ttcactaata tctacccaac tataggctaa 119820 acaaatatta tcatagtctt cttttctaa ctgagtatat ctgcgaaggt gtctttcatg 119880 atttccttct aatagaatga cgttttttaa tttaaaata atctcaagat actcaaacat 119940 ttgcttcgat tctaatcctc tatcaaaata atctccgaca aatatgaaga gttcattttg 120000 attatctata atgtaatcag tagggaaaag agaatgaagg gctgtaaaac aagaatggac 120060 atctccaatt acatgaattt tctcatatga atcagtattc atgagatttt tgtcccactt 120120 aatagtattt aacaaatcat tttatctac ttcttttgca aaacttggga tattctcatg 120180 ttttaaacgc tcatagatat tttcaataac atccacagga actttcttta gttcttgtct 120240 attattatta cgttcaaaaa gagtgtctag ctctgcttct atgttaacca catatactct 120300 atatccgtat ttttttgata acttctcata ttttttaatt agtttagccg tagaatgtgt 120360 agcatctatt acagtaact ctccattttc catacgcttt tctatatgt taaataataa 120420 atcccatacc ttgttgtctt cttcttgtga tattctagg tttccttctg tatcatatac 120480 aggtgcgctg tattgcgttc taggatatc agggctaaga gatatccct ctaatccatt 120540 ttctttata tacgttgttt tacctgagcc tggacct ctcattagta tagttgttct 120600 catatttcat tctccttgag tgatttatta tgttattgct tatacatcat ttttcctttt 120660 cttttatata ctatagcagg aaaacaaa tcctccta tcctatataa aaagtctcct 120720 tcttaatatt cctttccttt atttatta tcaagtactc ttaagtcact tttagaca 120780 tccatgctag aggtatgtct attattacca tctagatttc catcttttaa cttattatct 120840 ttcatgattt cttttttaat ttgttttct gtttttttt tgtcatagt gttttcaata 120900 tcaaagaca tctcttcaat ataagtgtt ttaataaat cataaattc cttaattgta 120960 tatctactaa ataatcttt atcctcaaag tacgtagcac aaaactttt acgtcttgtt 121020 agtacaccta ttgacttatt ggaagtagca atataaacat gatatgtttt tccttttact 121080 tttattttaa atcttgtatt atctaacaaa tggttatagt cttaaataa gtaattgttc 121140 aaaattagcc ctcctttgcg ttaacccaaa tttatagtat tttattgtag ttttctctcc 121200 gctgtagtaa aggtgtcatt attccaacca ccatcatgat tataaactc taaatcacct 121260 gtcacagtac ataagacatc aaaactaata ttttcttttc taccttttga aatacctgtg 121320 taaactattt taggtataca actaagggtc tgtaatccta aaccatctat atattctcta 121380 aaagatacat gaggtaataa ataagcactt aattcactac tgatacttct actaaaataa 121440 atgataatgt ctccaacagg tagttcatcg ttatatagat ctacaatatc atcttcttca 121500 atagtccatg ttgtatgttc tatatctgca ggtgctacat gaacaagttg tttaacttca 121560 ccatgtataa tggactcctt atagaaacct acagcgtttg cttctctaa atactgtgca 121620 ataaaagtac cgtcatcact attaaatat ggcgttctat tttgaaaatc tatagattgt 121680 tccatatcta gttttcgta ggtatccttt aagtactccc taattttt aacatctttt 121740 gttttaactt tattgttcc taccttaact tttattctg tcattattt agtctcctta 121800 taagtacttt ctactggtt ccgagtaatc attatatcc tttactctg gatactttaa 121860 atactaaaa gcaatatac ctagagctac ataggtgct aaaaacca agccccagaa 121920 tgttaatact gtttgtaaga aaaaacattac actactact aaaaaccatg tagctactac 121980 tagtaatgtt gtactgtaa aaaaata cttttcccaa aatccacctt ttgaaactt 122040 tttgataat ttttcatca taatattct ccttatattc caatgcttt tttgctaat 122100 acatctacat attcattcca tttgttatta tcatgagcct ttacttat aaaatttata 122160 tcttaaact ttgagtattc ccttagcata ttatatg tttactta attgtttta 122220 gttttccacg aaccttcata ccattgaata agtcctatat atctacatg ataatagcc 122280 tgcttataac ctagttttat agcctctca ataccataac aacaagctag tatttcacct 122340 gcacattat tatacttaat taactacta ttcatag gtttactgat ttctttaca 122400 atgttctcat ttttatctaa ataatagct cctgctccaa caacctttt attaatagat 122460 gagctaccat ctgtatatat taatgcagtc tatgcatat tttagccctt ctacaaagca 122520 agggaacatc tcacttgtat aaatctcttt gtagtcttgt aattttag tagagaatc 122580 aaaaaactta taacaatgtt cttctgcttc gatatagtca tctgcaataa cattaacttc 122640 aaaaccatca actaaaata cgaacaattt cttaaacatt taaaaaaccc ctttatatatt 122700 taataggta cttaatttaa tcaatttcag tgtactttc tgagtgttct agctcttcta 122760 atttttcttt tactcttca agtctgtatg actctctaa aagttcaac tgctctaata 122820 atgtgatact atcaaattca ctactattaa tgatgttgtg tatatattct agatgtgtgt 122880 ctttaataat gtttgttaag tcatcaccag tataataatc ctcgatatac gataggtctc 122940 ctaataactc agccgtactt ctaataac tattattaga tattaggg windows 123000 ataaacaatt atctaattta ttacttaaat gctctactac tttttgcatt gtattacctt 123060 tttcttcagt actatatgaa attctaatat tagggtttt agaatcataa tcaactaaag 123120 aactcctatt agtgtttaat aacttatcta aagaagttaa aataatagct ctatcttcta 123180 tattatctaa ggttaagata atatctataa tagtataaaa tgctttgtct cctattgctt 123240 tattaacatc ttgaagttca aaaatattaa tcatatcctc aatctcatga cgctcaacaa 123300 agttaataat agattttgta aatttattca tcaacatcaa cctctttaaa taattctaca 123360 ctattagtat ttaaagcttt ttctaatttc ataagattag cactcttagg ttttctttta 123420 ccactctccc aataagaaat aagtgagtag tgaactccaa tctcttgtgc taaacttcta 123480 actgtatgac ctttttcttc tcttacttt tttaaattta atactttagt ctcttccata 123540 ataaaccact acctatcttt cttcaatttt taaataacta tagttatttt tattataagc 123600 atacttattt aaaacgtcaa gcgttttttc tttagcctct actttacctt tagctttcat 123660 attackacatag aaaacattac ttttattga acgtgtgtgc ttatata ctttgtactg 123720 cgtaacctca ctttttata cattacgtttt aaaccatttc tttaatttt ccattatta 123780 taaccacctt taaaacttat atagtattg tagcatatga taaatacatt gtcaacttaa 123840 aaaayaaaa attackaggga aaattcccta gtacattatt tccagttaat acgaccccaa 123900 tacttctctt tagcatacg ttcccactg tcagtgatt tacatactgc catatagaag 123960 ttaccagctg acgggttgt aggatattta aacctaatcc accagtagcc gtctgcttta 124020 ataacttggt caaagtttac atattgacca ctataaataa atgattcagc acctactatt 124080 gaacccctta aacctgtgt gcgtcttacc ttaatcgttc tatcagcagt aaatttacct 124140 cccaatttcc aagttgttg tacctcgtct tgaattag gttctataa ccacatagga 124200 aagtcgtaac catgggctct aacggtagct ttctcccagc caccgcctcc ttgagcatct 124260 cccaagtcc aacctccacc taaccaatta tttcatta ctataatttg gttttggttt 124320 gcacttagta cccatgcgac atgaccataa ccgcacccgt atgaattatt aaagataacc 124380 atagtgcctg gttaggaat gtaggatagt gtattttcta ctactctagc tttatcttttt 124440 aacatagctt tattatccca tggaatgtta catgcacttg ctccacctaa agaataacct 124500 gggaagagct tgttaaatcc atagttagct aagtcgtaac attgctgacc ataccaacca 124560 tcaaagtcta ttgctttgcc ttctagactt tttaaaaatc gaacaaattc acttctagtc 124620 atcgatgctt tcaaaagttt tcactcctta tttccaatct atttttccaa aatatttttc 124680 tttcttaata cgctcttgtt tatctgttat ctcacataca gcacaataga aataattttt 124740 actagagcct ggttttggat atttaaatcg aatccaccag tagccgtctg ctttaataac 124800 ttggtcaaac tcaacccaat catccttatc gtatagccat gaatctctat ttactatagt 124860 gcctttaagt cctggagatt ttctaacttt atagctcta tctggataaa aagtaccttt 124920 ccagctccac atagttttag tagattgtgt ttttactcta ggctcagcat tacctgattt 124980 ctttacatct actgacttaa taactttctt gtaatactta gctacttcct tatctaagtt 125040 actagtgttt ctacctaatc cacatgcttc taataagtta cctgggtctt gtttgtcgtt 125100 ttggatgtct tggtgacctg gcatatttgt tttgtaatca acaccccagt attcagctaa 125160 ataagctaag acacgagctc cattgtctaa tgatttttta gaacgttctt tatcactaaa 125220 gtaacaaatt tctacaccaa tagcaccatc attagcgtta attccgtacc ataggtcatc 125280 cataggagcg ttatacaaca catgccaagc tttttctgta gtaggaacac atatgatagc 125340 125400 atttttgtaa taatctacat tattttgagc tgtagtatta atattccctg tatcatgagc 125460 tacaataaaa acgggttttt taaccgccat agcttgacct gtgcgtcttg ttccaatagg 125520 tagtaaatca tacctaacac ttacaccttt ccaaatttct atcattactg ttcacctact 125580 tcttttgggt tatcttcttt atctaattca gacactaagt ctttttctac tttaccatgt 125640 tctaatggtt ctgcatgact tgtatctatg tcttcattat taactccttc aggagccatc 125700 ggcatctttg taggaggtaa ctctgaggta ctattcattg cttcactctt gtatgttaaa 125760 gcttatctg ggtcattata atctctaggt ttgttaaagt cctgtacaat agggctatcc 125820 gctatacctt tagtgtcatg acttacaaga acacctaaac cagtcaagaa actaataact 125880 acacctgcaa ttgcagtgcc ttggtttaca atactcttg cacctttgat tcctaataaa 125940 ctacatacac tgacaataaa cgtagctaaa acaggtacaa aacctgtcca aaatgtagcg 126000 ctttttgctt ttgcagtaat attgttacct gctattaata atggtttttt atcttttttt 126060 gacataaaaa aaataccatc ctttctgtta ttgtaaagct aataataata taacaaaaag 126120 aatggtttta gttattaaat tttaagttat tgttctttaa tttgagaaag tgttttgatt 126180 acttctgaca tttgtttatt atctaagtct tctaacttag tgtgtggaag taaatctaat 126240 tttcccaaa tatctttttt agttgtgaat tttcattaa taattgctct accgattaaa 126300 cttcggtat aataaatttg ttttgcagat gccatattag tatctaccct tctatagtat 126360 aattaaacat acatacataa accgtctcac tggtaagtaa catactagac ctattgttaa 126420 gttaatcact acgcttgact ctattaggta gctaacctaa gtccatctca cgtaacctat 126480 taaagcagta caaccgtagg gttgattctg tttaatattg taatgtgata ctaacatatt 126540 aattagtaac tttcacatgg tatgaagaat tttagcggta ttctataatt tgaccaatta 126600 ttattttgca ggtttatgct acttgtacta gtatcgtatg tttcaaaca tttttcaatg 126660 ctccaactgc atatacttgt taaggtgtat ttgtaaagga ttccaccaag accctttaca 126720 aaaattaagc ccatcagata ctatacttta taaacctaat atgttactgc tgagtattcc 126780 gattgtaata agcattacta ttgacgaatt atctcaccga tataaaccga caagttttaa 126840 ttcgttcgac aatctcacgc cttacaggta ccaccctgtt taaatcagcc attatgtatg 126900 tatgtttaat aatactactt ttaaagtata acatatatttt attcggttgt caagaaaaat 126960 ttataacttt ttatagtttt tttatactag ggtaaaaag ttttaaaga cctagttttcg acaaataaaa ataaggagga aatacacttc aatttgacaa caattaatc tctatgcaat cttaactata atataacata atattctaag tttgtcaagt tctttttct ttttatcttg ataattcttc ttgtatttta tcccaatatt tttctgattc tgttctatta tcctcaatgt gagcagttgt acatttacac ctgatacaat gtaaatgttt tatgtgtcct tcttctcttc tttgagctct ttttcttggt actgtaaaag tattaccaca ttctgaacaa actaaattac tgtggaacat tttctgtctt tttttcatga ttatcaatcc ttttaaaatt ttttgtatag ctagtatatc fatherattat tttgatgtca attackac tgttgttttg fataaagctt attack attack attack attack attack attack attack attack attack attack attack attack attack attack gaggattcct father father father actagtta father fathertaatag gaaagtcaac aaagagtaat aaaaaaaagt gacttactta aaagtcacta attttcaaat actaacttaa atgattctat gaataaaggg ttaatgaata 127680 ctgtatcaga attaatatcc tcagagactc taactctaac tgatgcttgt ccatgtcctc 127740 taattgttcc atttatctct ctttgtgtat actcaatact atcgtcagag attaaataat 127800 atttttttcc actaatcatt gttacctcag catgttttac catatcaaaa ctcctaacta 127860 aatttattga aaatgaaagt tataatagaa cctaacacta gtagtagtac tttctcggta 127920 gtatccttct ttcttgtgtc cttaacaact gtattgttag tgagttcttt tatcttttcg 127980 tctaatctat ctagctgtat gtagatagac gattgtttct cactattaac agctacttct 128040 ttgtctaaac taactaccat ttttcttagt tcatcaactt cattttctaa ttccttatac 128100 gtatttttat caatatagct accatcttgt attttatctt ttatcttatc tacttgtccg 128160 acaaggtttt ttagttcttc attcaactaa agtcacctct taatgtctaa cttttcagat 128220 tctgaatgga cgtcatagtt ttcgaaaaag tcattaataa tttgcatata atcctcagta 128280 actatctcac catatgacgt tttagtattt atttcaacc taagcttacc aactcatgg 128340 aggtctattt ctttaataac ggtattagga ttatcagatg gtagtata atatcaaa 128400 tatatag agccgttgat aagcaacta tcaatcctat agacgtgga gatttttcta 128460 tctcgtctaa agtgagctaa ggcatcttta aactctatt ttatatc ttatactta 128520 gtcaaatcaa cttaccccct tataattaat ttgagctac actagttttg tgttatata 128580 gttattgtag tagcagat gagtattacg tttaaaaa ttagcacca ccactacct 128640 gtacttatta accataatga aaaacagat attatataa caccaccaa gtagcctata 128700 tattcatag tgttttaca ctctttaat actactacgt atgctagtga tttagatag 128760 ctaaaacagaa agtaaaaata aaaaaaaa agaggtatag ctataatgct tgctagtata 128820 atcactatt acacctatt tcttttagct agatataaa atcttatata atacaacttt 128880 atatacat tgaaacctgt ttaataatca acatgttac attagtg tacggtatat 128940 tttaaattag gaggactgaa ctaatagggg gatataataac atagctgtat ttatatta 129000 aactctaata attatttt tattttgtt tattttgtct attattact cactgtcatt 129060 atatactct attcgaccta gtacagttat gacttacttt atatttggtg ggatagttttc 129120 taatgtggca ttaacataa ctgataaatt attackacac aaagagacc ccttacccga 129180 ttattattcta aaagagtag agctaata caatgatta caagtatta agaaattgt 129240 aggagtcacaa actaatgttt ctgctgagga agtagagta agagcaaag cacaacgtcg 129300 agtactaaaaaaaaaga gagatgctgt caatgaaaac gagaaggac atttaggaac 129360 aacgtaaga gctgaagat aatgcaaccg ctgtttcctt aaaaaaaga gaggataac 129420 gtattgcaag tcctagtagg gtgtgttgtt tgtgtgtca gtctctttca ggaatgaatt 129480 attackaagg taagctata gctaaagtta atcattttca ttcagtac actaagtact 129540 tatattttga catgtgcgca gatatata actgttacaa gatttaag aaagtaggtg 129600 aattgataga gtgagcgctg aaagtttaag agatatgtta tctaagaaga aaattgaaga 129660 cgaagataaa cgtaaatata tagctgatgg atttatgtca ggtattatacta aacttatgta 129720 tgactttaat aaaaagattg acagaggggga aatagaagta aaagacccta atgatttgta 129780 taaagtgttt gttatcttcc aacaaatgca aaacttaatt acagatggtt ctgatggtgg 129840 cggtgctata ccgcaattat caagaccaca acaagagctc tttgatgaaa taacaaatga 129900 gaatagtaaa ggtgagaaag aagtagattt agagaagtta tctcaactat ctgctgatga 129960 tattactgct atgattattg ataaagaaaa ggttatgaac gaagagaact caaatacatt 130020 ctaaagaaag gtgtatatga atggatggta aagaattatt aaaaataaca caagaaacat 130080 tcggtacaca aaatgttacg caagaacaag ttgaccatat tatcaacatg ttaaacccta 130140 gtacttatat gctaaaatat catacgttac gaggtcaccc gataactttt agtattccaa 130200 acagggacag aagtaaagca caagctcata gaccataaac tagtgctgtg gtctttaaac 130260 tctgttaaac ggtcatagga aaaayaa tatcctgta agaaagcta agtcctaatg 130320 gatgagctg ataccgtagt aaagaatcta cacatgtag aggaaaact ctaacgacta 130380 aatttctagg tagttatcta atggagata gtgagaacta gatagaaaa ctctttatag 130440 agagtaag cagagaaccc ttaaccaaaa ctaagggcta taatatagtc taaaccctta 130500 aaatatcg ggaaaccgag ggtagtagtg ggcaagttaa gattgtcaac gatagtcacc 130560 ctataaagc ggtaattaag agtagacaat taggactcag tgagatgtca gtaatggaa 130620 tggtacactt tgctgacatg tatagttaca gaatgtaaa gtgcctctat acgttccctc 130680 gattaacag tgtgggggaa ttaaaacctt gttaaacggg catagtaaaa taatgtatag 130740 aaaaaacaat atactggtaa gaaaccctaa atctgactat accagacag tgggaaccaa 130800 ccgtgctaac tgttgacttt atatgtagtg tatgttatac tgttattata aagttagcta 130860 aaagcctaac gactaaactt actaatact atataacgg attagtga atagtataa 130920 gaaatttta actaaacatg tagaaagaaagtatatt gtaatgacta aaagaaaac 130980 actaaagag ttgttcaag atgtgtataa tctagtaggt gacgagtata ctgttatata 131040 tgccaagat aacaat cattgatacg ataccttac tattaca tggatgaat 131100 agacaata ctttcgtatt tagttaaaaa agtaagcaa ggagctacta accaaatta 131160 gtagctatga tatagtctaa tcccctataata atatcggga aaccaagggt aaaaatgac 131220 acagagcag ttaagaaat ttgtacagtc acgtcttaat cctgtattag ataaaactta 131280 ttttagagat attgtgaatt gggataaga ctccttaggc tataaacaa ttagaaactc 131340 aagtttgttt tttagaacta gtagtaaacc aggttcagtt gagggtgttg acatagactt 131400 cctcgcaatg gacgaatttg agagggtgaa ctcactagcc gaagttcgg ctttagagtc 131460 tatgtcaagt tcacctttta aagtagtaag aagattctca actccgtcag cacctggggt 131520 aggtatacac aaattatatc aacaatctga ccaatgtac tatgctcatg tgtgtcaca 131580 ttgtcaat gaaaacgaaa tgaaatatgc tgattgac cctaatgact taaatagag 131640 tggtaatctt ttacttta acccagatgg tattgatgaa caagctaaaa cagtacaaga 131700 aggtacatat caatacgttt gtcagaatg tggaaaaccc ctagaccgtt ggtataatgg 131760 cattggaaa gtaggtac cagaagaac aaaaaataat tcaggtatta gaggttacta 131820 cattcacag atgaatgctg tatggatag tgcaagccaa tagtagaga aagaaatgaa 131880 tacagattct aagcaagcat tttataacta ttctttggtt atgccttatg aagatgttaa 131940 aatgcgtgtt ttaccagag acatctttga caatagtca gaattgca aaacacagtt 132000 atttaataga gataaataca atttattc agtaggtata gactggggta acttccactg 132060 ggtaactgta catggtatga ctgaggaggg taagtagat ttaacgtt tattctctat 132120 tagaaaaaac agtagaccag atatggtaga agcagattta gaagctataa tattagagat 132180 atctaaatat gaccctgata ttattgttgc agataatggt gattcgggta acaacgtact 132240 taaatttatt aatttctttg gtaaggataa agtatttggt tgtacttata agtctagccc 132300 acgctcatca ggtcaatt atgcacaatt taatgaaaac agtatacag taactgtaga 132360 taaattaatg cataataac gatataca agattaaa gctaacgta windows 132420 ccaacaggta gatgatgaat taaaaactta tcttaagcac tggcaaatg tcctaatcat 132480 ggacgagaa gatgaaaaaa caggagaact ttcaagtt atttaacgta aaggcgacga 132540 ccattattct cagtctgcct gtattggtta catcggtctt actcgtctaa aagaattata 132600 tgacaaaggc aacggtacat ctttcacatc cactttatta tcaacggatt acatactac 132660 aaaaacaac tcgtctaatg agttctattt tgatgacta gaaggactg acgacttgac 132720 agtatatta attatgata catacaga agtagatata agtaagaga cattaattt 132780 atttaattgaa gaacctttaa ctttatctta tgtttctaaa catagtgatt ctttagatag 132840 taaatatgac tacatatata aatcactagg ctttgataac ttcatggact gttattata 132900 cgtaacaga gaaccagaac gtatatacaa aggtggagct aagatataa gctcattgaa 132960 taaagtaaa aagactgtag tacgtaatgg gaagaaatt gaatgacag tctatgaga 133020 taaaaat gatgataac ctaaagaaaatggtgaa gaaccaaaag aacctaaac 133080 tgctaaggt tcaaggttc ttactcatgg tgatggg aaacctacc ctaaaaagat 133140 tgccagttct ctttctactc taagataa gggtgtgaac actgaccaca tagatggcaa 133200 cgcatcaatg tataaagaat ttgtagatga tgtaatac acataggac tagcttcctt 133260 taaagaaact gattacgata tcatattaca tggatatgta tcagacctcg aaactaatgg 133320 ggtaggtgct aggtctattc tagagttaat ttctttagca aaagaaga acagaacgc 133380 tgttgtttat taggtttat tatctcaagc catagagttc ttaaagtctt taggtttat 133440 taaacgtaaa gatgagtag tgttgaaaa acagatata aagttatttt taggtagta 133500 cagtgagctt atttagcact gtactcatttt atacgattat atatgtaagt attattat 133560 tagtagttgt aaatgtaata gtaaaagaaa aaagattgaa taatactaag cagttactta 133620 tacaagtaaa aaaggatatt ataataact taaaaaaggg agatatgaat gattaaagat 133680 aataatacaa aaacattgga agagttaatt acacctattt ctacaaaaga aaaagaaaat 133740 aaagttaaag aatttagtaa aacattatgt gaaatgatta gtaagttata tgagtcttat 133800 aatgtgttaa gacaagaccc tattgatgaa acacaaagat tagatggttc tctaatggtg 133860 tttcaaagta gattagatga tacattaaca ggtgaggaac accaaaaact tttcaagtta 133920 gcctttgatt ataacattaa tatctttgaa gctaacaaac aatttaaaaa agatgtgcaa 133980 aatggaaatt ctattaagtt aggtgatgtt gttgtaaccg acacagcttt aagtaatgtt 134040 ttatctagta atgagcttaa tgttagtatt acatttatgt taagcaaaga ctatgaagaa 134100 aagaaacgta ttgaagaaga agaaaaggaa aaactagata agttataata gatattatga 134160 gacctttatg gataggtagg aataaataat atgaaacgta agtttagtag taatgagatt 134220 actataacac ttataactat tgtagttgct ctatttatag tattattac agtagcattt 134280 aaaagtacc aaattgctaa agagataag gagaatac aaagctagt agaatttat 134340 aaaaagcag atgatgatga cggtaaaact aaaaaaggt atgttgagaa gttaatagg 134400 gctgaggaag aacttaaaaa ggttaaagaa gaactatt aaaggtta taatgaaaa 134460 acagaaaaag aaagaata agagataag agtgtaag aacgtatttta tggtaatgat 134520 Aggtaag Attagtatt Agtaataat Aggttgttg TAGTAATGA AgTACTAG 134580 cctaagataa tagagataa tggtgtcagt acagttgtag tacctcctgt tgtaagtcct 134640 gttgagccac caagtgaacc tagtatacct tctcctacta tacctaacc tattattcct 134700 aatcctatta accctaatcc tatttacct aaacctaca tccctacccc taaccacta 134760 ccccctatag aacctgaaaa acctatagaa cctgaaaaac ctatagaacc tgaaaaacct 134820 atagaacctg aaaaacctat agaacctgaa aaacctatag aacctgaaaa acctat 134876 <210> 3 <211> 136156 <212> DNA <213> Artificial Sequence <220> <223> PN1815 <400> 3 ttgagctagg tttttcaggt tctataggtt tttcaggttc tataggtttt tcaggttcta 60 taggtttttc aggttctata ggtttttcag gttctatagg tttttcaggt tctatagggg 120 gtagtgggtt aggggtaggg atgttaggtt taggtagaat aggattaggg ttaataggat 180 taggaataat aggtttaggt atagtaggag aaggtatact aggttcactt ggtggctcaa 240 caggacttac aacaggaggt actacaactg tactggcacc attatcttct attatcttag 300 gtctagtaac ttcattactt acaacaacct tattatttac taatactaaa tctttatcct 360 tatcattacc ataaatacgt tctcttacac tcttatcctc tttatttctt tctttttctg 420 ttttatcatt ataaccttta taattagttt cttctttaac ctttttaagt tcttcctcag 480 ctctatttaa cttttcaaca tacctttttt tagttttacc gtcatcatca tctgcttttt 540 gataaatttc tactagcttt tgatatctgt ccttatcttc tttagcaatt tgatacttgt 600 taaatgctac tgtaattaat actataaata gagcaactac aatagttata agtgttatag 660 taatctcatt actactaaac ttacgtttca tgttatttat tcctacctat ccataaaggt 720 ctcataatat ctattataac tttataactt atctaacttt tccttttctt ctgcttcaat 780 acgtttcttc tcttcgtagt ctttactcaa cataaatgta atactaacgt taagctcatt 840 actagataaa acattactta aagctgtgtc agttacaaca acatcaccta acttgataga 900 cttccattt tgtacatctt ttttaaattg cttgttagct tcaaagatat taatgtata 960 atcaaaggct aacttgaaaa gtttttggtg tgcaacacct gttaatatat catctagtct 1020 actttgaaat accattagag aaccatctaa tctttgtgtt tcatcaatag ggtcttgtct 1080 taacacatta taagactcat ataacttact aatcatttca cacaatgttt tgctgaactc 1140 tttaatttta tcctcttttt cttctgtaga aataggtgta attaattctt ccaatgtttt 1200 tgtattatta tctttaatca ttcatatctt cttccttttt taagttattt aataatcct 1260 ttttacttg tataagtaac tgcttagtat tattcaatct ttttctttt actattacat 1320 ttacaactac tatataata atacttacat atataatcgt ataaatgagt acagtgctaa 1380 ataagctcac tgtactcacc taaaaatac ttatatctt gtttttta tacatagtaa 1440 tctttattt taataaccc taagatttt aagaactcta tggcttgagg taattctata 1500 tcataaacta cagcgttctt gttctttcttt attgctaaag aaatttaacc tagatagac 1560 ctagcaccta ctccattagt ttcgaggtcc gatacatatc catgtatatat gatatcgtaa 1620 tcagttctt taaggaagc tagtcctatt gtgttac tatcatctac aaattcttta 1680 tataatgatg cgttgccatc tatgtgtca gtgttcacac ccttattctt tagagtagaa 1740 aggaactgg caatctttt agggttaggt ttctcagcat caccatgagt agaaccctt 1800 gaacctttag cagttttagg ttctttgtt tctcaccat tgttctctt aggttca 1860 tcatttat tatcttcata gactgtcatt tcaatttct tcccgttacg tactacagtt 1920 ctttttactt tattcaatga gcctatatct ttagctccac ctttatatat acgttccggt 1980 tctcttgtta tatatata acagtccatg aagttatcha agcctagga tttatatatg 2040 taatcatatt tactacta aaatcacta tgtttagaa cataggataa agttaaggt 2100 tcttcaatta ataaattaaa tgtctcttta cttatatcat cttcttgtat tgtatcataa 2160 tttaatatac ttgtcaagtc gtcagtcctt tcttattcat caaaatagaa ctcattagac 2220 gagttgtttt gtgtattatt ataatccgtt ggtataaaag tagatgtgaa tgctgtacca 2280 tttccttgt catataattc ttttaaacga gtaagaccaa tgtaaccaat tactgaagac 2340 tgtgcgtaat gcatttcata ccctcggttt cccgatattt attaggggat tagactatat 2400 cttagttatc taaattgata actcagtgct ttacgaataa aataatttat tgtttaacaa 2460 tttctctata cttttgtaat ccttagttgt atagaatatc tcaaaaagct cataaccgtt 2520 atcttttgca taagaacttt ttatactatc tatcttttt tgtagcttaa attgttcttc 2580 tcctccaaaa tgcttgacag gttaacgtg ttgttcacct tgatattcga taagtaagtt 2640 atattcaggc aaataaaaat catatgataa gttatttatt aactttaagc cttcaaaagt 2700 tttttgtttt ttatatgtta tacctttttg ctctagataa cttctacta atttctcacc 2760 tatggaattt ctacagtgtg agcatcttct accttttcta aaatttgcca tagttccccg 2820 atatgttttt ccgcactcat tatgctttat ttctatgggg gtgtgtgcat ttttataatg 2880 atttgaaact acttcatagt ttcctttcgt ttctttacgt acttcaaatt tatatcttc 2940 caatgtccta ttaaatctcc tgttacatct cgaacattgt ttatacttta aaattctct 3000 tgcagtaata gtataagtac tatcacaaaa gaaacagtgt aaagttatct tcttaaatgc 3060 accttcatat tttgttatag ccattatacc ttcaggtaat tccttttggt attcttcatg 3120 tgtttttct tgcttactat ggactcttt ttgagaacat gtattacaac ctgtcttacg 3180 tttactcata aatgttgatg gtgttataag tattttgtta ccacattttt tatgaatagc 3240 tcttagtttt gtgtactgat taacatagtc atctaaaaat tcatattctt catagtcctc 3300 tggtctaaca tctttaattc tattaataaa ccactcgtta tcataaacca cttaactacc 3360 ctccttttta gtatactcaa taaattattt taatctctta cgttaatagt aacgaattta 3420 gtcgttaggc ttttatctta atttaataat aacattaaaa aatataatgt tatatttaa 3480 attaagaatt tagcacggtt ggttcccact gtctgtgtat agtcagattt aggttttctt 3540 accagtatat tgttttcta tacattattt tactatgccc gtttacact gtttatagac 3600 gaccatatta caaatcgtc tcctctgcgt ttaatactt ggtacatttc acctgtctta 3660 catcatcct catcatgat aacattt tgccaatgtt tagatag tttactct 3720 tcatctactt gttgatatac actaatacgt ttagcttta aatcttgtat ataacgtttg 3780 ttatgcataa gtttatccac agttactgta ttgttattt cattgaactg tgcatataat 3840 tgacctgatg aacgtggact agatttataa gtacacccaa attackttatc tcttchaag 3900 aaattaatca atttaagaat attack gagtcaccat tatctgcac gataatcg 3960 gggtcgtact tagagaactc catataattt ctttctaggt ctgctctac catatcaggt 4020 ctactattct tcttacaga aataaacgt attaaatcta catgaccgtc ttctgtcata 4080 ccgtgtacac agcaccagtg gaaattaccc cagtcacac tgcaagaat aaatttgtat 4140 ttgtctctat taaatattg tgtttttgca atttctgat tattattga tacatcttct 4200 tctgttactt tcattttac gtcgtcaaa ggggctccga tgatgtagtt ataaaagctt 4260 tgtttagatt ctgtattcat ttctttttct ttaatctcat cacagcttat ccacgttgcg 4320 tttaattgac ttatataata tcctctgata cctttattat tttctgttct ttcagcatgc 4380 ttgcaatccc aacgaccagc gtaccaccta tcaagaggct ttccacattt ttgacaaaca 4440 tattggtaag taccatcttg gacagtttta gctatctcat ctatcccatc tggatttact 4500 agtaatacat taccactatt ttctaagtca tcaggtttat aatcagcata cttcatttca 4560 ttaaaatgac cgcagtgttc acaatcataa ccataaaacc attggtctga ttgtttatac 4620 agtttatcta taccataatc tcttacagtt ggtgtagacc accttcttac tattttaaaa 4680 ggtgaacttg acatagattc taaagctgag ctctcagcta aattatttac acggtcgtac 4740 tcatcaagtg aaagatagtc aatcaatttg tacccctagt ttcctagtac tttaacactc 4800 acttaagagt aggtttagac tatatcataa cctttctatt aggtgaaagg ttctctgctt 4860 tacttccgcc aagcggtttt cttatctagt tctcactata cccttttgta tagctaccta 4920 gaaatttagt cgttaggcat ttagctaacc ttataaatac attatatcat attcttttta 4980 taaagtcaac atttagcacg gaattgccct cgtctttacg ttaggggttt ccccgtttaa 5040 cagagtttaa tgtggacttg ttacctatcc acaccttcga cagtactagc tttactacta 5100 gttctgaaaa ataaactaga atttcttatt tgtttataac ctaatgagtc cttatcccag 5160 ttaacaatat ctctgaaata aggttttct aatactggat taagtcttga ttgtacgaat 5220 ttcttcatct gttcattcgt cggaaaggta tacaaacatt ttacacttgc ataactatgc 5280 atgtcagcaa aatgtaccat ttccattaca cccatctcac ttacaattac taccgttagt 5340 ttcctaatac tttaacactt atttaaaagt cggtttagac tatatcttca atatataaat 5400 aataatttat attacggat tatatattgc cttgctttac ttctattaac gaaaattttt 5460 tatctaagta agatttcata cttgaatatg tgtttatttt gtaggtaggc tcctataaaa 5520 caaagtcatt atctttagca aatttatttt tatattatc gttaacttgt tgttttttaa 5580 acctttcttt tgctaactct ttagatatac cttcaaattt cttctgttct tcgtacctaa 5640 tgttacttc ctttaagtat gtttcaatat attcctctcc acgagacttt ttacagtaag 5700 ggcaacctga atggtgttga ataatatctg tatatctaac cttaaatgtc ttattacaat 5760 ctttatgtaa taattttact ttattaccag caccattata ttctgatact aacttataac 5820 ttgaccctaa atgttctttt atattactat ctatttcctg aggtgttaat ctttgacttt 5880 gatagtaaca agctatacat ctagaatgat acaaaaagtt accaggtgat actttatact 5940 ctctaccaca cttgttatgt ctcataagta taggtgttgc tctattaata taatcttcaa 6000 gtaccgtata ttcatcacct acaagggtat agacttcttt aataaattct tttgcgtct 6060 tctttctcat attaaacctc ttatttacgt tatagtttt cttatctagt tctctttatc 6120 tccattcaga taataccta gaaatttagt cgttaggcat ttatattaat tcaataataa 6180 cataagtatt ttactgtc aactattaaa ttaagaattt agcaacggat tgtcatatgc 6240 ttctttaagc acttagagtt tcccgtttta acaaggtttt acttgaacaa agtttatcca 6300 agctgtctac ttttaattac tactttatttt gggtgtgtgt cattactat cattactac 6360 cctcggttc ccgatattta ttaggggact agactatctc atacatgtac cttttggtgt 6420 acatgccctc tttctttacg ggttttatcc ctcttatact gttctaccta atccctttg 6480 attagttacc agtaagttta gtcgttaggc atttacgtaa ctaaggtata tatcctagtt 6540 cgatttagca attgattgcc ctcgtcttta cgttaggggt ttccaatttt agaaaaggtt 6600 tatagtccgc atagtatgtt tacggacttg ccaaggtcta tgagcttgtg cttacttct 6660 gtccctgttt ggaatactaa aagttatcgg gtgacctctt aacgtatgat attttagcat 6720 ataagtacta ggatttaaca tattgataat atggtcaact tgttcttgcg taacattttg 6780 tgtaccgaat gtttcttg ttatttttaa taattcttta ccgtccattc atatacacct 6840 ttctttagaa tgtatttgag ttctcttcgt tcataacctt ttctttatca ataatcatag 6900 cagtaatgtc atcagcagat agttgagata acttctctaa atctacttct ttctcacctt 6960 tactattctc atttgttatt tcatcaaaga gctcttgttg tggtcttgat aattgcggta 7020 tagcaccacc accatcagaa ccatctgtaa ttaagttttg catttgttgg aagataacaa 7080 acactttata caaatcatta gggtctttta cttctatttc ccctctatca atcttttat 7140 taaagtcata cataagttta gtaataccctg actaaatcc atcagctata tattacgtt 7200 tatcttcgtc ttcaatttc ttcttagata acatactct taaactttca gcgctcactc 7260 tatcaattca cctactttct ttaattctt gtaacagtta ttatatctg cgcatatgtc 7320 aaaataag tacttagt actgtaatg aaaatgatta acttagcta tagctttacc 7380 tttagtataa ttcattcctg aaagagactg accacataaa cacacaccc tactaggact 7440 tgcaatacgt ttatctccctc tttgttaa ggaaacagcg gttgcattat cttttagctc 7500 tttacgttgt tccttaatgt ccttcttcgt ttcatcgac agcatctc tttttactt 7560 ttagtactcg acgttgtgct ttgctctta ctcttactc ctcagcagaa acattagttt 7620 gtgactctac aattttcttt atacttgta attcattgtt atttagctct acttctttta 7680 gatataatc gggtaagggg tcttctttgt gtataata tttatcagtt attgttaatg 7740 ccacattaga aactaccca ccaatataa agtaagtcat aactgtacta ggtcgaatag 7800 agtatatta tgacagtgag tattatag aaaaaaaaaaaaaattatta 7860 ttagagtttt aaatataaat acagctatgt tattattcac cctattagtt cagtcctcct 7920 aatttaaaat ataccgtaca ctattaatgt aacattgttg atttataac aggtttcaat 7980 gttattatta agttgtta tatagattt tattacttag ctaaaagaaa ttaggtgtaa 8040 ttagtggtta tactagcag cattatagct attackctcttt ttatttttttttacttt 8100 ctgtttagct tatctaaatc actagcatac gtagtagtat taaaagagtg taaaaacact 8160 atgaaatata taggatactt ggtggttgtt tatatattat cttgttttc attatggtta 8220 ataagtacag gtagttggtg gttgctatt ttattaacg taatactcat atctgctact 8280 acaataacta ttaacaca aaactagtgt agctcaaat tattatag ggggtaagtt 8340 gatttgacta agtataaga tatattaaaa ttagagttta aagatgcctt agctcacttt 8400 agacgagata gaaaatttctt caacgtctat aggattgata ggttgcttat caacggctct 8460 attatatatt ttgattatta ctacatacca tctgataatc ctaataccgt tattaaagaa 8520 atagacctcc atgagttttgg taagcttagg tttgaata atactaaaac gtcatatggt 8580 gagatagtta ctgaggatta tatgcaatt atttagact tttcgaaaa ctatgacgtc 8640 cattcagaat ctgaaagtt agacattaag aggtgacttt agttgaatga agaactaaaa 8700 aaccttgtcg gaagtaga windowaa gataaatac aagatggtag ctatattgat 8760 aaaatacgt aataggaatt agaaaatgaa gttgatgaac taagaaaat ggtagttagt 8820 ttagacaag aagtagctgt tatagtgag aacaatcgt ctactacat acagctagat 8880 agattagacg aagataaa agactcact aacaatacag tgttaagg cacaagaag 8940 aaggatacta ccgagaagt actactacta gtgttaggtt ctattataac ttcattttc 9000 aaaattta gttaggagtt ttgatatggt aaaacatgct gaggtaacaa tgattagtgg 9060 aaaaaatat tattaatct ctgatgatag tattgagtat acacaagag aaataatgg 9120 aaaattaga ggacatggac aagcatcagt ggagttaaa gtatctgagg atattaatc 9180 tgatacagta ttcattaatc ctttattt agaatcattt aattagtat ttgaaaatta 9240 gtgactttta agtaagtcac ttttatta ctcttgttg actttcctat atatatatta 9300 tattatta tattagtat tattatttta gttattatta tattattatta tattattag 9360 gatcctcct tattttccaa atagtaaag tatctaaata ttcagataa ttaataata 9420 ctagtaataa gctttttaca aaaacagt atttgtattg acatcaaat attatatga 9480 tatactagct atacaaaaa ttttaaaagg attgataatc atgaaaaaa gagagaaaat 9540 gttccacagt aatttagttt gttcagaatg tggtaatact tttacagtac caagaaaaag 9600 agctcaaag agagagaag aghacaataa acatttacat tgtatcaggt gtaaatgtac 9660 aactgctcac attgaggata atagaacaga atcagaaaa tattgggata aaatacaga 9720 agaatttaca agataaaag aaaaaagac ttgacaaacc tegatatta tgttatta 9780 tagttaagct tgcatagaga ttaatttgtt gtcaaattga agtgttattc ctccttattt 9840 ttatttgtcg aaactaggtc ttttaaaact ttttaccct agtataaaaa aacttaaaa 9900 agttataaat ttttcttgac aaccgaataa atatatgtta tactttaaaa gtagtattat 9960 taaacataca tacataatgg ctgatttaaa cagggtggta cctgtaaggc gtgagattgt 10020 cgaacgaatt aaacttgtc ggtttatatc ggtgagataa ttcgtcaata gtaatgctta 10080 ttacaatcga atactcagc agtaacatat taggttatta aagtatagta tctgatgggc 10140 ttaattttg taaagggtct tggtggaatc ctttacaaat acacttac aagtatatgc 10200 agttggagca ttgaaaatg tttgataca tacgatacta gtacaagtag cataaacctg 10260 caaataata attggtcaaa ttatagaata ccgctaaaat tctcatacc atgtgaaagt 10320 tactattaa tatgttagta tcacattaca atattaaca gatcaaccc tacggttgta 10380 ctgctttaat aggttacgtg agatggactt aggttagcta cctaatagag tcaagcgtag 10440 tgattaactt aacaataggt ctagtatgtt acttaccagt gagacggtttt atgtatgtat 10500 gtttaattat actatagaag ggtagatact atatggcat ctgcaaaca atttattat 10560 accgaaagtt taatcggtag agcaattatt atgaaaat tcacacta aaagatatt 10620 tgggataaat tagattact cat aagttagaag acttagataa taacaaatg 10680 tcagaagtaa tcaacact ttctcaatt acgaacaat acttaaaat ttaataacta 10740 aaaccattct ttttgttata ttattattag ctttacaata acagaaagga tggtattttt 10800 ttatgtcaaa aaaagataaa aaaccattat taatagcagg taacaatatt actgcaaaag 10860 caaaaagtgc tacattttgg acaggttttg tacctgtttt agctacgttt attgttagtg 10920 tatgtagttt actaggaatc aaaggtgcag aagatattgt aaaccaaggc actgcaattg 10980 caggtgtagt tattagtttc ttgactggtt taggtgttct tgtaagtcat gacactaaag 11040 gtatagcgga tagccctatt gtacaggact ttaacaaacc tagagattat aatgacccag 11100 ataaagcttt aacatacaag agtgaagcaa tgaatagtac ctcagagtta cctcctacaa 11160 agatgccgat ggctcctgaa ggtgtcaata atgaggatat agatacaagc catgcagaac 11220 cattagaaca tggtaaagta gaaaaagact tagtgtctga attagataaa gaagaataacc 11280 caaaagaagt aggtgaacag taatgataga aatttggaaa ggtgtaagtg ttagatatga 11340 tttactgcct attggaacaa gacgcacagg tcaagctatg gcggttaaaa aacccgtttt 11400 tattgtagct catgatacag ggaatattaa tactacagct CAAAATG taggatta 11460 caaaaataca tataacattg attgggcttc tactgcatcc gcacatatct ttgtagatga 11520 taaagaagct atcatatgtg ttcctactac agaaaagct tggcatgtgt tgtataacgc 11580 tcctatggat gacctatggt acggaattaa cgctaatgat ggtgctattg gtgtagagat 11640 ttgttacttt agtgataag aacgctctaa aaatcatta gataatggag ctcgtgtctt 11700 agcttattta gctgaatact ggggtgttga ttacaaca atatgccag gtcaccaaga 11760 catccaaaac rakaacaag acccaggtaa cttattagaa gcatgtggat taggtagaa 11820 cactagtaac ttagatagg agtagctaa gtattacaag aaagttatta agtcagtaga 11880 tgtaagaaa tcaggtaatg ctgagcctag agtaaaaca caatctacta aaactagtg 11940 gagctggaaa ggtacttttt atccagatag agctattaaa gttagaaaat ctccaggact 12000 taaaggcact atagtaata gagattcatg gctatacgat aaggatt gggttgagtt 12060 tgaccaagtt attaaagcaa atggctattg gtggattcga ttataatc caaaaccagg 12120 ctctagtaaa aattattct attgtgctgt atgtgagata acagataaac aagagcgtat 12180 taagaaaaaatttg gaaaaataga ttggaaaa ggtgaaa cttttgaaaag 12240 catcgatgac tagatgaa ttgttcgat ttttaaaag tctagaaggc aaagcaatag 12300 actttgatgg ttggtaggt cagcaatgtt acgacttagc taactatgga ttacaagc 12360 tcttcccagg ttattcttta ggtggagcaa gtgcatgtaa cattccatgg gataaag 12420 ctatgttaaa agtaaagct agagtag aaatacact atcctacatt cctaaccag 12480 gcactatggt tatctttaat aattcatacg gaggcggtca tggtcatgtc gcatgggtac 12540 taagtgcaaa ccaaaccaa attagtaa ttgaaataa ttggttaggt ggaggttgga 12600 cttggggaga tgctcagga ggcggtggct gggagaaagc taccgttaga gcccatggtt 12660 acgactttcc tatgtggttt atagaaccta atttcaaaa cgaggtaca acacttgga 12720 attggggagg taaatttact gctgatagaa cgatttaggt aagacgcaca ccaggtttaa 12780 ggggttcaat agtaggtgct gatcattta ttatagtgg tcaatgta aactttgacc 12840 aagttattaa agcagacggc tactggtgga ttaggtttta atatcctaca aacccgtcag 12900 ctggtaactt ctatatggca gtatgtaaaa tcactgacaa gtgggaacgt atgctaaaag 12960 agaagtattg gggtcgtatt aactggaat aatgtactag ggaatttttcc ctagtatttt 13020 tttattttta agttgacaat gtatttatca tatgctaca tacatatata agttttaaag 13080 gtggttataa taatggaaaattaaagaa atggtttaa cgtaatgtat taaaaagtga 13140 gattacgcag tacaagtat atattagca tacacgttca ataaaagta atgttttcta 13200 tgttaatatg aaagctaag gtaagtaga gggctaaaga aaacgcttg acgttttaaa 13260 tagtatgct tataaaaa atactatag tattttaaaa attgagaaa gataggtagt 13320 ggtttatta ggagagaat aagtattaa atttaaaaa agtagagaa gaaaaaggtc 13380 atacagttag aagtttagca cagagattg gagttcacta ctcacttatt tcttattggg 13440 agatgtaa aagaaaacct aagagtgcta atcttatgaa attagaaaa gctttaaata 13500 ctaatagtgt agaatttatt aaagaggttg atgttgatga ataatttac aaatctatt 13560 attackttg ttgagcgtca tgagattgag gatatgatta atattttga acttcagat 13620 gttataag caagttgatt atgattctaa aaaccctaat attagaattt catatagtac 13680 tgaagaaaaa ggtaatacaa tgcaaaagt agtagagcat tgagaaaaaattagaaa 13740 ttgtttatat caatcttacc ctaatatatc taaatagt attattagaa gtacggctga 13800 gttattagga gacctatcgt atatcgagga ttatact ggtgatgact taacaacat 13860 tattaagac acacatctag atatataca acacattatt atagtagtg aatttgag 13920 tatcacatta tagagcagt tgaactttt agagagtca tacagacttg agaagtaa 13980 agaaaaatta gagagctag aacactcaga aaagtacact gaattgatt tattagta 14040 ccttattaaa tttaaaggg gttttttaaa tgtttaagaa attgttcgtt attttagttg 14100 atggttttga agttaatgtt attgcagatg actatatcga agcagaagaa cattgttata 14160 agttttttga ttctctact aaaattac agactaca agagatttat acagtgaga 14220 tgttcccttg ctttgtagaa gggcataaat atgcataaga ctgcattaat atatacagat 14280 ggtagctcat cttataataa aggtcttgtt ggagcaggag ctattattt agtaaaaat 14340 gagaacattg t'aaagaat cagtaaacct attgaaaata gtagtttaat tagtataat 14400 aatgttgcag gtgaaatact agcttgttgt tacggtattg aagaggctat aaactaggt 14460 tataagcagg ctattattca tgtagattat ataggactta ttcaatgta tgaagttcg 14520 tggaaaacta aaaaacaattt agtaaaaca tattata tgctaaggga atactcaaag 14580 tttatagata taattttt aaaaataag gctcatgata atacaatg gatgaatat 14640 gtagatgcat tagcaaaaa agcaatgga atataggag aaatattatg atgaaaaaat 14700 tatcaaaaa gttcaaaaa ggtggatttt gggaaaagtt attttttt acagttacaa 14760 cattactagt agtagctaca tggttttg tagatagtgt aatgtttttc ttacaacag 14820 tattaacatt ctggggctg gttttag cacctattgt agctctaggt attattgctt 14880 ttagtatttt aaagtatcca agagtaagg atattaatga ttactcggaa ccagttagaa 14940 agtacttata aggacta aaatgaca gataaag ttagatagg aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaat being 15000 gttaaaaaaaatgttaa taaaattagt gagtactta aggataccta tgaaaaaaaaaaaaaaaacaaaaaaaaaaacta 15060 gatatggaac aatctataga ctttcaaat agaacaccgt atttattag tgatgatggt 15120 acttttattg catagtattt agaaaaagca aatgctgtag gttttattaa ggagtctatt 15180 atacaggaa aagttaaca acttgttcat gtaacaccctg cagatataga acataacg 15240 tggactattg agagatga tattgtagac tatatacg atgaattgcc tgttggagat 15300 attattatta tttacata cgagaagtac agtagtgaat tagatgcata tctattacct 15360 catgtatctt tagggacta catagatggt taggta tggatagcat ttcctatct 15420 agagtagttt acacaggtat ttcaaaggt agaaaagaaa atattagttt tgatgtactg 15480 tgacaggtga tttagagttt attaatcgtg atggtggttg gatataatgac acctttatta 15540 cagcggagag aaactaca taaatacta taaatttggg ttaacgcaa ggaggctaa 15600 tttgaacaa ttacttattt aaagaata accattgtt agataataca agatttaaaa 15660 taaaagtaaa aggaaaaaca tatcatgttt atattgctac ttccaatag tcaataggtg 15720 tactaacaag acgtaaagt tttgtgcta cgtactttga ggataagat tattttagta 15780 gatatacaat taggaattt attgatttta ttaaaacact tattattga gagatgtctt 15840 ttgatattga aaacactatg aaaaaaaaaaaaaaaaaaatca 15900 tgaaagaata taagttaaa gatgaatc teggtat aaatagacat acctctagca 15960 tggatgttct taaaagtgat ttaaggtac tgatatta aaaaagga aggaaaagg 16020 No No No No No No No CTTTTAT 16080 aggatagat aagatttgtt tgtcctgct atatatata aaagaaagg aataatgatg 16140 tagcaat aacatataa atcctcagg agaatgaat atgagacaac windows 16200 gagaggtgct ccaggctcag gtaaaacaac gtatataaa gaaaatggat taggaggata 16260 ttctcttagc cctgatgtcc ttagaacaca atatagctca cctgtatacg acacggaagg 16320 aaacttaga atatcacaag aagaagacaa caaggtatgg gatttattat ttagcatatt 16380 agaaaagcgt atggaaaatg gggaatttac tgtaatagat gctacacatt ccacagctaa 16440 actaattaaa aaatatgaga agttatcaaa aaaatacaga tatagagtat atgtggttaa 16500 catagaagca gagctagata ctcttcttga acgtaatgat aacagacaag aattgaagaa 16560 agttcctgtt aatgttattg aaaatatata tgagcgttta aaacacgaga atatcccaag 16620 ttttgccaaa gtagtagata aaaaagattt attaaacact attaaatggg ataaaaatct 16680 tatgaatact gattcatatg agaaaattca tgtaattgga gatgtccatt cctgttttac 16740 agccctctat tctcttttcc ccgctgatta cattatcgat aatcaaaatg aactcttcat 16800 atttgtcgga gattattttg atagaggatt agaatcgaaa cagatgtttg agtatcttga 16860 gattatttat aaattaaaaa atgtcattct attagaagga aatcatgaaa gacaccttcg 16920 cagatatact cagttagaaa gagaagacta tgataatctt tgttttgcct atattcatt 16980 agataatac aagagatt ttataaca agctttaag atatttcatg cavaggatt 17040 tttacctacc ttatatctt tattaggaa cggaatact caaacaggg tttaagctat 17100 tcttagaaaa ctacaacagg ttgtttattt taactttaaa ggacagact acattattag 17160 tcatggcgga gtccttcctg aagttcttga taatttaat aagatttca caagtcagct 17220 tattaatgga atcgggggat atgattta tgttgatgac caatgggaat attctaatac 17280 ataaata catggacata ggatttata tagaacct ttagacata ctaaaaatttc 17340 agttaattta gaagggcgtg tagaaaagg tggttgctta agagctataa cgataataa 17400 aaaacaac attgagaac atgaataa aaacactatc tacgacccta atttctttt 17460 atcaacaga cggaacgata atattgacaa agacctacc cctaatcaat acctagatat 17520 agctagaaaa gaaaaaaa ccatcaaaac cagtcaacaa tatagagatg tattctcggt 17580 taactttaca aaagagcttt ttctaaaaa gaatggaat cattaacag tgagctctag 17640 aggtctttat attgatgaag gtagaaatac agtattagga agaggatata ataagttctt 17700 taatatcaat gagtagaag aaaaccaatt gaggaatatg ccagacacta tccaattccc 17760 tttaactgga tataaaaaag aaatggatt tttaggacta atgttctatg acccgttaga 17820 aggaattgta tatgcaagta atctaaaac ccattagt ggacatggaa aataatgc 17880 gctactattt aaagagttag tagaaaaac ttaccaaa agacaatac aaatactagc 17940 aacattcctt gaaaaccatt atattgctga cgatagtttt accctagtgt tcgaggtagt 18000 tgatattgaa gagaccccac attackacataa gtatgagaa agtagtattt tcctactcga 18060 tattattcg aacacactaa atatggaaaa gaagactat gattatttga gatatgttgc 18120 tgatgaagtg ggattacaat taaaagaaaa agagttagag ttgctagct gggaagaatt 18180 ttataaatgg tataaggata ataatggctc ttatata ttgcatgag gatatgtatt 18240 tgaggattg aaaggattta tgttattata tagtctgac tattacaag actgaaata 18300 tatgagagat atagcttatt ccttatcaca aagagagat gtaagaccta agcaatat 18360 tttagcaaga aaccctgaac ttagagattt ttattattgg gctaaaatga aagattcaga 18420 tgaacttgat aagatatta cacatag agatgatttt gaaaagaaa aggaggta 18480 gatggcaaa tctattaaaa gatttacaa tctataatgg gggacatata ttgaacgatg 18540 caatggtaaa atagaaac aaacaggcag accaatcaa tggaatcatt ggtgttaat 18600 gttataatgt attagatgat aaatcaatca atgacaagc taacgcagaa caggttggggt 18660 tagctgaacg tatcttgaat aatgacttta aggctatgca agagtcagat atatttgtat 18720 tcgatgtatt gatgaggga ttaggtaca tagcagagat tagtattctt ttggtatga 18780 aacaccaagc tcaacaatt atcaacaat repeated agattgt repeated 18840 aaaacacaca nagatgatata ttagaagcgt atcatgtcgt cataaacct gttttaattt 18900 attgctctga tattcgtca gggcacggga aaccatacac tgacccac agagcagagt 18960 ttcaacgaa ccagttgtc tatggcatgg tttcatt aaccaacggc aaaggcttta 19020 tttcatggga agaagtttta ggggaattag aaagttagg tgcatctaat gtctaattta 19080 gctcatatat taagcatctt atatgctata ttagttactg taggatatat acctgcttta 19140 gtaggtttga taagaata gatgttaaa ggtgtagata gctattttg gttttattat 19200 gttgttacag tagtattag cttaacaagc ttatttgtaa cacatgcacc cctatttcaa 19260 attatatcag tagtattaa tttattacta ggtattattt gttttattat atacttattt 19320 agaacacag aagttagtct tttagaatg gttatgttta taattgttat ttatattggc 19380 tattcagtag ctaactatag tgttgaatac ggacaaataa tggctactat tagtattatc 19440 gtagcttatt tatcccaat aaataattt tataaaacta aaagtacaaa tggaactagc 19500 aaatatttat ttcttattat aggtattgca ttagcttgtt taattattag tatgttaata 19560 aaatacga caccacatgt atattaca gagtagcta actttattct tattatgata 19620 tgttacctac aggcatctta ttatgaat aaagcgtag atacaatga agacttaat 19680 aaaaaggt aaaaatttt attaaggt tagaatggt gataccttat ggactataag 19740 windows gatgtgtcta ttAAacact acagaactt atgatatga cctcggtgtc 19800 tttatcagac aaagattgta tacttgttta tgtagactag aaggacttc tatatggatt 19860 taatagctaa taagaagta actagtaccg atgagattt tttaaagt aaatctaaaa 19920 attattatat taggatata attatat ctaaagttac tgtacaca gatgagttag 19980 aggaagtttt agcaatgcct atactatta actttaaaaa ttctaagaag tacaagact 20040 tatgagtaa tcccgatatt gtacccgtaa gagaactaaaaaattaa tatgaactt 20100 atctagaaga actgtaaaa agttctcttt tttgttgac tattaaattt aactagtta 20160 tcatacttat fatherata atgaggtgat vakacatgtc agtactat aaagaaacag 20220 gattaacgga agaagaatt cttaaattac ctaaagtaa tagaatagt atattattag 20280 gtgaagaaag agtatatta aaaaataata aaaaatat tgtagatatt ggctctaaag 20340 attattaag agatattaat atacctttt gttattctag cgctttaaat ttacttttat 20400 ttatagcatt atgtggaat aaaaaactta ctacgtttaa gggagacccca tataaaaag 20460 tacagagtt aagtaaaca gttacagatg taaatactgt atagtgag tatatagaaa 20520 gtgacgaatt gtctgaattt cctttatata aaaagaca ctacgtaat atatatact 20580 gccgtgcaaa ctatgaaaat gaactaaac agttttgacaa tacgcaaat aagaatagta 20640 atattacct tashaaaaaaaaatagact taaaaaagaca ataattact acaactaatg 20700 atatacttga tgtattatta atgggtgact atagtatatt tgtattaat attgaccctt 20760 atgcattttgg taaatcttat gataatact acgaatacta caatgaagtt ttaaaaaata 20820 taaaaatagg gcttaacaaa ttaacaccta taaaagaata taatactccg tttttatta 20880 agacttgtta tttaaagac ataagtatag taacacaga ttggagtata gtaaacggtg 20940 actttataa taaaaatgga aatgtatacc tacacctacc aaatacacta cacataag 21000 Aatttaaatt taaatgtat gagatgatt tattaagga taaatttaaaaacatta 21060 ctttacctgt ccttttaaat attattttaa gtaatatgg aaggaaaat ttagcttta 21120 acatataat storm agaataatg attackt aatctaagt agacttaatg 21180 taaaaaactt tgatgtatac tctatgatag atagacctga tggttatcgc acagttagta 21240 aaggtgaaaa tactactgat atttaaaca atctgttaaa attagttgtg tctaatattg 21300 aataagtttta taacaacgaa gattgtgata tatttaaga acaaagag tttttagta 21360 taccaaaaaaatgg aaattacatg aagctttaaa tttaaaaaaacatata 21420 ataagtttat tactcttaat aagaagagc aagaaatta cttaata cttcgagtta 21480 tcataataa atttcctagt ttatataatg agtctaactt acacaaacta ttcgatgacg 21540 actttataat ggtgactaat tcatattca taggaatgc tttatcttt aaggtacta 21600 cgaaagaagt tcttacttt tcattttctg actttagaaa atggtgaat tatataact 21660 atgatgtcag aacagacaa cgtatacatt catacgctgt taataattta tatagagatt 21720 atatagactt tgcttcagac ctagtacttc ttggatatag aactaagaa agtattaact 21780 taacaccata ttctttaaaa ctagagcatg atattgttac tgatgagtat ttacagtta 21840 agatgagt cgatgactta agttacac aaaaatatga dad attaatca 21900 CAAAAAGA ataagtta aacgatggct ctaaagttaa atttttacct gcggatacta 21960 ctgaaaaatt aaaaagagaa ggtgaacagc tatctcattg tgtcggcagt tatgcttcga 22020 attattaaa tgacagatgt ttattac tagctagaa agttgacgat ttagaaaaat 22080 catggtatac tgtagagta aggataaaaaatgata tacgttaggt storms 22140 ctttaaaag tcatgagtta cctaaagaat taaaagacga attaataaa gatttaaaa 22200 atataata acaatttagt gaggatgttg cgtaatgta aaccagtta taactttaga 22260 acctaagaa gttaagacat tatagagta tttaagtcat tttgagaag atgtacgaaa 22320 ataataagat atggaaat tatgaag attacacaa aagtatcagc ttgctaagg 22380 aaactacgtt gagtaatgga aaggtagt aagaatatg tagatataga cattacagtt 22440 aggchattag tachaacc tttagagac tttaatgatg ttachaata window 22500 ttagtagaag atatatcgt cgttaatagt ttcagatt atgttaagt acagaagtt 22560 aaaataatg atatagatta aaggcaag gaactgttat attaatgtg tactttatag 22620 tacacttcca taatatcttt ccttttccct atctatattc tagataggtt ttttatttta 22680 gatcgaaag ghaccaata tggatactag agatttatt gatcacaa ttggaagta 22740 aaaaggca ahaaaaaaaaaacatt attgagca ctttagatgt 22800 gabacattct ttagatgaca cattattatta tgctaaaag cttatgaaaa atgtagaaca 22860 actggagtta tactataatg tcaacctac cactaataca ccgaaccatt ataaggtaa 22920 aaagatgtt atcatttt tagagata ttctacatt attggcttta tagactgcat 22980 gctatttaat attgttaat atacaac attagga aagacgatg aaagaaaga 23040 agtagagaaa attaaaacct ataccgaaag gctgttaaac ttcatagaat atggtaatag 23100 taatggaga gataaaaa aagatacaca atactttg ttacttatac ttctcagatt 23160 acttaccatc aaaaggtata gttgttttaa atcataatgt tacctctcat gctacggaga 23220 acggagttaa aattattac atagtaata ttctaataga taacgcagaa atacagttg 23280 ttatagactt aacggatttta caaaagcaa gtagtagca aaatatgtta gaatattga 23340 aaaaatac agaatcttgt atatttaaaa gcaagaatt aactag atgtaata 23400 ccttctttaa aggagaaatt ttatgaaaaa attaatata tgtttaacta ttatatcatt 23460 ctttatcaca tataaagtgt taacaaaaaa gaaaaagcat acacatgtca ttgtagactt 23520 ttcaatacaa gaccatgaac atttaaataa tattgtaa taaagggcaa ttgcccttt 23580 tttgtgtttt atgatatatt aacattgact atagtaaag gagattttca atgcctcatt 23640 taaaagcata tgaataatac ggtaatatat tggcaatagg ttacaatgta gagttacatg 23700 aagaagtagg gtctgtaatc atacctact tagctcctca cacacactac cctcaggtg 23760 agttctatgt atcatgggaa gctgaaaaat atgaaccga taaagtagta gttcctggtt 23820 ttacaaccct agaatcatca ttcaaagaaa taacattata ttttaaagac catatacttg 23880 taaatgctaa atctgcttat gatgtagcag tagataatgg ttttgtcggt tctgaagaag 23940 aatgggttaa gtctattaaa ggagaaaaag gggagaaagg ggaacaaggt aagcaaggtt 24000 taagtgctta tgaagtagct gtaagtaacg gttttacagg ttcagctaca gattggctta 24060 aaacaggtaa aagtccttat gtatactcta atgagtatat aaagcaaaaa gatgatactt 24120 cggatgttca aaggttaaga cgtgctatta aagatacaag tgaaggtaat accctacaca 24180 ttccttctag tgaatcacct attaaatag atgatacttt gataatagat aagaatatta 24240 atattgtatc tgatgctaag attgtttata atggtagtaa ggataaacca gctattaaac 24300 tagatagttt atcatattct aatgttacaa ttaaaggtat ttatgatgat agttcttatc 24360 caacttatgg tggaggctat catggtttta agagtcaaaa ctatatagga ctagaattag 24420 ttaactgtag aaatgttaat actaatatta atgaaattat tggttttaca gtcggtaata 24480 aacataaagc tactggtggt aaaggtcatt ggtttaataa tactattatt aatttcttta 24540 ttaataatga aacacatata gatttaata cagatggtat aggttctat ggtgagcaat 24600 cttggatgaa tagtattac ttctaaat cagcttttc atagtgc actgagttta 24660 aaacaccc taacacatac tataacatca aaaaactct aaaaatgct atacctag 24720 gaggaaatag caatgtattc gattcactta aatttgaac tgcttccaca acatctgaaa 24780 attatgttat gtgtatctt aaaaagcag taggattt atttaagaat tacagatttg 24840 aatttaata haaagctacc ttgctatta tagattaga aacacaagac atgacaaat 24900 cttatgtaac acatagtaaa gatattaagt ttattcctga atttgtttta ggtaatggac 24960 aaactaac gtttacaaat attackactg ctaaaatacc tagagtagt attgctaaaa 25020 tagtagacga atacaaca acgttattgt aaaaata tgattttagc aaagacta 25080 gagattagg aggtaactat cacacagtca aaaatgtatt tagaaacca ttacagtca 25140 cttctctgac agatgaagta tcttatgact atattacac acctagttta gtagatgata 25200 aaggactact tacctttaca gggctcgtacc ctatggcttt atatgttaat atgttagtg 25260 ttggtgacga gctattatt aacaagttat catttatagg taattctagt ggtatatta 25320 ttaatgttt tgataagac ggtatatat tagacaagt atctaataat tatgataca 25380 tattactga tggttat aatgataaat aaagcgtt cactttcaat aacgcccaaa 25440 aagatacttt tactgttaat agtgagatg ttaagtctat cgttatttta atatctggaa 25500 ctatgcaagg tttacttgta gattcaacta atccatccaa tattattag tctcaacg 25560 atagtagcaa gataaaact gatgtttttt attctcatgt taaaccttct agtgttgaag 25620 attttaata tgatgaaaaa gtatacaaca atggtacaac acagtatat ggttggggtac 25680 taaaaggta tgattggaa gaactaggta aagacacta ttctagagt aaagtaag 25740 ttatataga agattaccacca agattaatg atgagataa tgactatcct agattccaaa 25800 gagctttaga ttatttaca agtactagg gaggtaacta aacagttgca atagaataat 25860 aaaaatatat aaatacttt gtattttatt aaaaaact gtttgccttg cttatagagc 25920 aatctgtaag taccaaaggt taaatgctaa gaatcctaa agactcaata actaaaacag aatctgaaaa gataaatggt atagttacga aagtagaaaa aatttgagt atggtataag gttaaatcct aagtactgtt acaatggaag tttagcaggg aaagttctaa gggattatta atcctatga agaccctcaa cgactattcc gtataggtga cggaagtaa gccacaagct attggtgga gaaaaatctt taccctaa taatagggat aacaaatagt ctccgcccgt actgaaaggt agggcttgga grandfather grandmother tagcgttcta ttgttaaga aagttaaac tttaaata tttaaatttt attctaaata actgttgaca ataattctac cttatggtat attatatact ataaggaggt gggaataatg tcagaagaaa aatataaacg tattaatt agactattac snow snow snow snow snow snow snow snow snow tcattcgaga ttcattaaaa attattttat tcagtattgt attgataaaa gagaaaatga aagtatttat tatagagata ctattaaaca tttatcagaa ttaaagaac atttaactca actacaaag siaaatatt ttaaatggtt aaaagaaca agtagacact ctaaaaatga 26640 agctattaaa gatgtactag ttcttttga aaaactttac actaatcaat ctaaatcagt 26700 aaggttaaa aaggta aagtactaa tacttattct atcagaatg atttattgcc 26760 tagtggttta tgtaggttta gagagtaga gatactttt cagatagaaa agttaggtag 26820 agttaaattt tctcaaaac agtataaaaa gataaacat atttttgatg aaatagaag 26880 taaacatag tttataaacc ctattac tcatgatggt aaatactggt acgtatctat 26940 gctataga gatgatttag tagcaaaaa ccaagttact gagttaacta acxaaccat 27000 aggtatagac ttagtatta aacattagc cacttgttct aatggtaaat cttataaaa 27060 tattaaaa agttctaag ttaaaaact aggaaacgt ttaaaacgat tachaagaca 27120 agtaagtaga aagtagaa tgaataagca agtaagag ttttaaaa ctaatatat 27180 tattagtta gaaaaagaa taaaactctt acatagaaa cttagtta tattagaata 27240 tcatattcat actatgacta aagaaatagt agaacaat cctagtgaaa tagtataga 27300 agacttaag gtaagtact taagaaaaaaaacatta tctaatagta ttctaagc 27360 taattggtat acattagag ataccttac tattaatgt gagatagag gatattact 27420 tactattgct atacttact atccgtctag tcaacatgt tctaattgtg gtaatcgttt 27480 aactaaaacaa gataaactat ctttatcaca aagaacatat aaatgttctt gtggaagtag 27540 tatagataga gattaaacg ctagtatta cttaaagaac tatagatact ccaatggta 27600 windows gtttaacta atcaacac windowsgatgat atgtaggatt ccgtaaatcc 27660 gattaacgc ctttggagta tcacacaac ctgagtagag tataaaag windowtagtaa 27720 tagtgaggt actcaaaag ggatacgttg aaaaggaat aaaatttata attattata 27780 agttttaact tacggcactc tattagtacc taaggaaca gaggactatt tattcaaac 27840 taagacacct actgtacaa acccacacg tgtaaagta acaggagta atacacat 27900 taaaggtgaa ggtaatccta catttat gtcaggaatc actaaaaact atttagactc 27960 tatagatgat atttcttcta gtggtagaga tatgtttaca ggattctcat ttcaactg 28020 tgatacatt cttgtagag gattacatt taagggaa tggtagta aggtgaatt 28080 tagatatgcg tcacctcgtt ctattggagt agcgtttaaa ggaagtagaa actgtaaagc 28140 atataatgta catggctata atatcatggg taatgttgta aatgcagtaa acactagca 28200 agcagtagat gtgtttatg gttactcaga cacattact atagatagtt gctcagctac 28260 acatgttta gagaatggtt ttacttat gggtggtact aaaatggat attatgttaa 28320 fatheratct acaggaatg gttcaagtgg atttgaatca ggaacagaaa atgttattat 28380 aagtaataat atacacaa ataatagta ctcaggttta agtatatctg gcactatta 28440 cacaatcact aaacgtaa tttatggtaa tgtaataa gggagttaa gtataaacc 28500 atctaatggt attgctatta caggaggtag taaggaatt atctaatg atatgtatc 28560 aggtaatgag ggttacgagt tgtaccttta tccaggagtt ataacatag atacaaaa 28620 taatgtatta aaacagata cacaagtttt aaaaaacaagt atttattatg cctcaggaac 28680 aactagtaa cctgtgtcag aaattaactt aaaaataat acattaagaa gtacaaatac 28740 tgctttggat aaagctatgt tcttaattt tgttatgt agtacaatta ctaataatga 28800 tataaaaaca gataaaggta atgattcatt aagtgttca ggttcttgta gtaatctatt 28860 cgtattaagt aacaatga aaaaactt aagtatttct agtaatgcat ttaatgttat 28920 aagtaagt aacatagctt ataatttacc taagtactg aacggtactg caataccac 28980 tacaggt tggattgg gagatattgt tgttatact agtagaaccc tacatcagg 29040 tagtcctgag aaatggagat gtactagcga tggattgct actaatga agtggacatc 29100 taatacggat tatacacaag gtcaattgt ttaatggg attatgtat ataagcagt 29160 agctcaggt acagtggtg gaacacaacc tactcataat aacggtgtta tatcagatgg 29220 ctctatactg tgggaattta tatccacaa agctatttt gaagtcataa gccaatagg 29280 tgtaactgaa agcattagta atacctttt atacaaggt caattgcta taataggttc 29340 atctgtatat gtagctaag gtacatcaag caatactgat tggataattt taaattagta 29400 aaaaggggat ttaatgatga cagagacaa ttattatta ttaagcac acgtggacaa 29460 atagtggat ggggatacta tacatgtaac tattgaccac ggatgagaa catactctga 29520 gcaagaata agattactag gtgtcgacac accaaag aaaaaaata attack 29580 agctaggaa tttacacaa ctatgttaga aggaagat gttttaattc aacatacaa 29640 agatgattct ttggtagat atttagctaa agtgttctac aaagaaaata aagagtataa 29700 Aattattagt gagaattta t'aaaaagg attackaaaaaaaggta atg'ata 29760 agaacttgac aacataaa atatatgcta tattatta gtagttaact aacgccctt 29820 aacaatgcga aacacagtta gcatttttta accttataat gagagtaaca gcctaccat 29880 atggtactg tgaaatcatt atattctacc tatctaccat cgtagaaaag gtctacggta 29940 acgttatgac cctatttagc gttactagca atcctgagta atggcattgg ctagttgtag 30000 ctacctagtc gaggggttcg agtccctgct caggatttt tttccacaag atacctacta 30060 aaatatctta cacctactta ttttaagt aggtgttttttttgact tctatttact 30120 tatgtgttat atttactata tactaaaaaa aggaatgatt atttacta aaaaaaatta 30180 aaatattga aattgttttt gaaacttag atagtgcggt gttagaacca gaaaatgtag 30240 agttgatact agaagtatt agtgagaaa aaactatgat agttgaat agtgaagtag 30300 atacaagtaa gtcagcaaa aaagtttcta ttgaggtag tggtatgaag gatgaatact 30360 ttgaagagtt tcatggtttc ttagatgagc cctacacat ggcattatat gatagatta 30420 gtggcaaaga tattgtttgt gtttgtttga attatgagga tggtacagac gatactgtat 30480 atgtacctta tcctgagtat gggcagtata attatatgca gagaataag tacgaaaaag 30540 aaatagacac tttatttatt acaatagagg atagagaca agagaacat gtaccaaatg 30600 atgaaaaacc taactttaat gaaggtgaaa cagaagaccg cacgctagaa ggtttatta 30660 gtcaagtaga ggatggagt aagataag gattgaacaaaaaccct ggtagahaag 30720 cccttaaatt ctacgaagaa gcaggtgaag tagcatcggc attatcacgt ggtaacctag 30780 aagctcttaa agatggtatt ggggacactg tagttacttt aattatttta gctcagcaac 30840 acgacatgtc attacaagag tgtttagagt ttgcttacgg tgaaattaaa ggtcgtaaag 30900 gaaaaacagt taatggtacc tttataaag aggaagattt aaatgagtga taactttagt 30960 caatttataa gtaaaaaaaag caatgaatta aacaaagcta cagaaaaaca aaaagatttt 31020 atctataatc atatagattg tttatatgat gagtttactt ttgatataga gtcattaagt 31080 aaagatgaag ctactgaact tataaatgat ataactatag agttaagctg ttcagatgat 31140 tttcttgatt ggtatgacta tcagtaaaga ataagcaggt aaaggttttg aaagccctta 31200 cctgttttt atatgctata ttattaatgt atcatacaac agaaagggat aacattatgt 31260 ctaaaaaatt aaaggtctac aacaaagatg aacagctaat tttaacttct gatgaagtta 31320 caggtagttc tgtaaaagta acattaacag atttaaaaacc taatactact tatataaaag 31380 gtgactttaa agtctcttgg ttagtcgatg gacaagaatc taataaaaca gatgtgccta 31440 gttcaaac attagagagt gaaaagaag ctgtagctca gcctgtcatt gtaacacat 31500 tagatatgggg taccgacgggg tacacaatca gcaatgaacc acctaagac actacaaaa 31560 tatggcttaa atcggaataa gaaggataa actataatgg caacttatt accacatttt 31620 tacacacag aaaaata atgggaa ctatataca aacctattgc taggagta 31680 tttataca tgaagaga ttatttagct cacaaggtg aaataggcta ttacattgct 31740 aagtacaag atggacac aagtattgag aacctaatg tgttgtttt ttatgatgtt 31800 aacgattg aacaatgac tttaaaa gaggaatga acagactatt aaatgatt 31860 atagatata atttacagg aaagtttaa cccttttctc tactaatt cttacaaat 31920 ttagaagacc ttactacgc tttaccaaa CAagaaaaat ttcatgtaga tacaatccag 31980 tcggataaaa gaaaatttc atttcctgat acaaatgcaa tcctgatatc 32040 ttagatgccc ttacggctac agataatcat gtatatatgg aagtaaata tttatataat 32100 ggtcatccta ttgatgataa aaaattaata aaaggaaaacc aagatttaaa aaattaataa 32160 cccagtaaag aacctgtaaa aaggttcttt ttttttgctt actgaaaaaa gtgtatagta 32220 ttagttgaca ctatattgat tatatgttat agttaactta acttaaagaa aggtttgata 32280 gatatgaata agatatatgt tatatatgca gaagaagatt cctattatga tgaagaacct 32340 accttagaag taatagggta cactactaat atagaagaag ctaagtatat taaaataat 32400 tacgatgcat ggtgtcgtat tataagagta ggggaagttg aaagacttac aaaagaaata 32460 cttgataaaa aacagaaact atataaacta atgtcaacgg cagtgataca aagagagcaa 32520 cattatttta aacccataca agaattaaat acaattgtag atgaggtatt taattcaagt 32580 aaaccagata ttgactttaa tgagaaatgt gaaattatcg tttattcatt aaataaaaaat 32640 caaattcagg tagatatagg tttacttttc cctactgagc caacagaaaa agaagtagac 32700 agtatcgtta atgatgtaaa aaacaaaatt aacttcatat taaaaaactg tgaaaatgct 32760 gacattagag aatcaaaaaa gattatgaaa atgatagaaa aattaaataa ttaggagata 32820 taaaaatgaaaaaaaact aaaaagta tgacgctagc cgaacttatg gatgggctt 32880 gggaatatcc tgatttaca aaaggaaga gattttacac agaaatca gatatgaga 32940 actttgttta tttcttcg gaagacggaa gaaatgtct tgccagtgaa ttatatcag 33000 ctgacgacac tttgaagtt gaagtcgaag ttgagagg atcacagaa gagactagg 33060 ttgataggtt gattgaatta ttcgagattc agaaggaga ctataactct acactatatg 33120 agaacactag tataaaagaa tgtttatatg gcagatgtgt gcctaccaaa gcattctaca 33180 tcttaaacga tgacctact atgacgttaa tctgaagttg gtagaatgat 33240 gcaaacctat aaagtaagtc tttgtatcaa gttcttagcg tctaaatgta attataaatt 33300 aaaaaagcat tattttgtgc aaagtacgaa tgaggagaa gccacgaata cggtattaaa 33360 actgactcgt aaaagctcc cgttccaac tgcaagcata gaagtagaaa aagtggaggt 33420 agtagaatga tgcctaaata tcgagtgtgg gacgaatata caggaagaat acacgatgtt 33480 gtaggattcg acttcatcga gaatgaagtt cactatgaaa actacgcgga agcagaagct 33540 ttaatacacg caagagattt caaagatgta gaacttatgc aaagtacagg acttaaagac 33600 aaaaacaaca acgaaatata tgcgggagat atagttgagt ttgaagatga aatattagag 33660 atgccagacg atgaatctgt aataggaaca attaatagag aatatatc tattgatgtt 33720 gtaaatggta ttcaattaaa agattttatg tttgagagcg caatctccga aaatgattac 33780 tttgagtata cagacaaaaa atctttcctt atgtacgact gtgaggttaa aggcaacgta 33840 tttgaatcat ctcatttatt ggaggtaata gaatgatacc gaaatttaga gcatgggata 33900 aagaatcaca aagaatgttt aatattgcta gatttgactt tgcagaccat acaatatt 33960 cacacctatt tgcttgtgat ggttacttag gagaaaaacct tgtaattatg caatctacag 34020 gacttgaaga taagaatggt actgaaatat ttgaaggtga tatacttaga tattgggggg 34080 attgtagacc tgtaatattt aaagaagctt cttttggatg ggttgaaggg ggagattaca 34140 taccattctc tatgatgtgc atttcagaga ttggtaatac tgaagttgta ggaaatatct 34200 atgaaaaaag gagtaaaaaa gatgaata ttccaagta gagcatgata attgtgagct 34260 atactactctt atagagaga taaatatat actagtaag aacagcttat 34320 window aatctgaag gatchaag agtachaggc atgtctagaa atcatgatgg 34380 tattgcttac cttaaacata taggatt tattgatgat atgattaca ttcatgaat 34440 Agaattata gatataat aaggggtat tatttgta tttatgaa tttattgaa 34500 atgtaaaaca gttaggctat actgttacca tagcaaata gatactacc aaaggaaag 34560 aaaaaatact tattaaaaaa gaaaaccaac aacctattgc ttgggtattt ctaaatgaac 34620 catattcttt tcgaagctta ggcacagata gtgagttatt tgatttaatg gtagaatatg 34680 caaaaacacc tgtaaagaa cgtagtataa gcaatagc aaagtaaaa cctttagact 34740 tagataccct tacagatgac tatgctaag taagagtt tatgctaaaa ttcatatag 34800 acatggaga catagtagaa tacattcaat atacaggata tadagaat gttattaatc 34860 attggacaga aggtcaaacg tttagagcag tagataagca aggacaat aacctatta 34920 ttatacacc taatggattt gaaaagtttt tttatacatta aaggtaag 34980 agcaaggttt cgaacaagta gatagagaac tgtttgaata tagatatgat atttcacatt 35040 aaacacctat gaactattgt aggtgtttttt atattata gaaagatatg taactactac 35100 tacttaaat tcacaggga taggtaggac atagaaca atatggaaa tcttattatg 35160 ttgacttttt attatattgt actttataat gttgacttttt ataataag tatataataa 35220 tactactac windowtac tactactac agttataaa tactact aagaccact 35280 atagcaacct catatataa aaaaggctcc tatatactaa actacttata tgctgtataa 35340 actatact ctattagt gtaagggag agggatat actactact ttattgtaa 35400 atgaatacca ttagttatta gtaatgttga catagattaa agagtaatgg ttaatgttga 35460 cttttaataa tagttatat attackcc actaattagg ttccttaggt agccccatag 35520 ccctgtcaga cccaccacc tatattaaaa taaggaacc tttaatttag gctccttata 35580 tttttaaat actcgtccct ttctttttc attcttgata gttttttcttc tacttgctta 35640 atattatggt caaaaggtgt atagtctaca agaccaagac tagatgcttt ttttaatcta 35700 tccgtaatta ctgaagtaga agtacttaat tctttactaa tttttttaat accataacct 35760 ttactgtata aatctataat ttcttgaata aatccgtttt catatatttt atatacttct 35820 ttccaatcta tacattcggt aggtaaatca ctgcttataa tactttgttt aatatagtca 35880 aagctgtgtt ctcttacatc tatttctatg tattttagtc cgtgggaaag tgcttgactt 35940 ttcttccatt catcgttttt cttattttct tctaacgtta agtgaaacct ttgaccctct 36000 ttttgctcta gataatgctg tacaccatga acttctataa cacaatcgta ctcaggtaaa 36060 taaaaatcat aacgtttacg attagaccaa tcaaatgatt tttcagcagt ataaataata 36120 ttttgttgtt ttagtacctg ctctaccatg gactctcctc tacttctgtg tttattaagt 36180 tccttaaggg atttcttcat agaagaacag tccgcacaat aatccctaga gtaattattt 36240 atgtgacttg tttttatttt ctttatcata ccacattcat tacattctac tataataaaa 36300 cgtgttgttt ctatcttacc atctttagct atcttttcct ccgttatatt ttcctttaca 36360 gtgaattttc ctaaagtact acctacatca taagggtaaa cataagggtc agcaactcgt 36420 tgtaaattac ctataataac attaagagca ttatacaaga aagtatcccc attactattt 36480 tctaatctaa catattcaat aaccttacct ttgttatttt gtttagaaaa agcatctata 36540 attttaagtt ctcctttatt atcttcaaaa cgatatgtaa aagaaagacc tatactattt 36600 ttaaaatcta tatcataaga taccttacca taatactttt ctttatcaag tttaggtagg 36660 ttatttaagt ccacagaacg tttaccatta aatcttttaa ttaaaaccttt tcttttacgt 36720 tcactgtatg ttactttatc taatgctact ctattaagag aacttatagt tattgttcct 36780 ttttcatttt tgtacacata atcataagtt acctcaggag ttttagactt taaagttaaa 36840 tacatcttat cctctaaacc tttataacta aaaggaactt ctatattttt cattttttct 36900 ataagactgt aattatactt tgtatactta gtctttttta aagggtaggtt agttaagtct 36960 acccacacct cgtgattact cttattaact tttataatat ttttgtccat atttttaata 37020 cctcgttttt tactatctac ttataatata acacatataa aggtgataca agaggtataa 37080 aaaaaatcgt tgacttatat taaaatatc attcttttat ttattgtttt gttgacttttt 37140 gtattactac tatgtagcta taccatttac atagtacctg gacagaccga tataggtata 37200 taaaaggtgt ggtattagtg gtattttacc cctgccccg tataatatat ttatattaac 37260 ctattgtata caatcctaat aaataataaa aaaaagaaa gggagtttat tccctttcaa 37320 tttgttttac atcatttcta tagcttctgc tttaatttgt tcgtagtctt taatccattt 37380 attagattct tcaacactca tatgttctaa catataatca gctagttcaa acactttgtt 37440 accaactaat cttgttgttg tatcgtctgt aaagtctagt ttagaaggta tatgttctaa 37500 tgctgtgata gctttattct cttttagttg gttaacaata tggatatatt tacctaatgc 37560 gtcgtgttca ataacgtcta tgtctattgt ttcatagaaa gctgttaata gtaagtcaag 37620 ttcgattcct tcaagttttg ctgtttgttc cctttggtta attaatttca taatttatca 37680 atccttttcg tttatgtgt tttctttata tttatatatt accatgtatc ttagtaagtg 37740 tcaacacttt tctttaactt tttttaagaa gttttacact attataagtt aagtaattct 37800 tttataacgc ttggtgctag tgttgttata tcatagtctt gtcttagttc gtctaagctg 37860 ttgtaatgct taatagttcc agcgtctttg tcactgcttt ttgttgtaat ttttttgtta 37920 atagccttgt ctatatcctc aaggctatta acgttgtcca ttaggtttat taaatcagtt 37980 tcagttaagt tcatgtgtat tgtctcctta gaataacatt tggttagcgt taaactctag 38040 tgtatcaaca tccataatca tttgctcaaa ttgttctttg ctcatatgat ttaaaataat 38100 gttagtaaag tgttctgctt tgtcttgtgc taatgtagca ccctcgtaag tgctaaagtc 38160 aatgtttgat ggtttacgtt ctgcttgtgt taattcttcg ttgtttaata attgttgttc 38220 taagtgttcg aatttgtcta gtgcgtcgta ttcaagtatt tctgtcataa ccgcttcttg 38280 aattgctaca actaataatc tttctaattt aatgtttcca tttgccattt ctttaattgt 38340 gtttttcata atttatcaat ccttttcgtt tattgtgttt tctttatatt tatatattac 38400 catgtatctt agtaagtgtc aacacttttc tttaactttt ttaagaagtt tttaatgtg 38460 ttgctgttcc ttacatctat tatattacat gataatctag tatatgtaaa gtgttttagt 38520 aaagaataa tagcaatttt acactagctt gaagcggttt aaaagcataa aaaataaggg 38580 ctaataaccc ttatttaata aagatattaa tattgtcttg taacctgata aaccaatcaa 38640 ttaatgtaat tattgtcgta ccgcctaata tagttacaat agcgtcagtc ttttctgttg 38700 aacggtagtt cttacctttg tatttaaatt taatcattat agttagccct ctttataatc 38760 ttcctgtatt aataaataac tctaattgtt tgtttaactc gtccatgata aagttatcaa 38820 gttcatgagc agtaatgttg tatttttgt ttcctgttgt cattgaaact acattgtaca 38880 cgttgtcaaa tttattaaag taaatgccgt actgtagtaa accccaatca ttgacataga 38940 tatcagtaac atctaaatca ttatgtttgc ttgaagcttc gttatatgtt ctaacaactg 39000 tgtaatcttg gtttaatttcc tctaaagtttt tataagtttt cataatttat caatcctttt 39060 cgtttgtttt attacatcta ttattaca gtacttagt gataaagtca agtgttttgtt 39120 taatatttt taataattt tgttttgtta ttatcaagtg ttagcttaac acatttgtct 39180 gttactgtaa ttcttttac acctttatta windows gaagcctt atttatatga 39240 tagtatagt catcacattc atcaatctct gaccatagtc tagtagt tgatattgtg 39300 ccttgtgttt taattctgtt gtaagtacct ttaatgtatt ctaataatct gttcattct 39360 catcaatcct ttcatatta tttattacgt cttatatatt acagaagtttt ctataag 39420 tcaataggtt attttaattt ttttcttta attack cgttgttatc cactaagtat 39480 aacatgttat tcattctat aaataagtgt tcattaactg ctttaacgtt tatattata 39540 ggtagcttgt ttgaatgtga tacgctaaag acttcgttt ctttaaatag ttctaatgtt 39600 tcatagctat catcaata agctaatat ttaacttgat atgtgtaga gtattttaag 39660 tcatttctat agtagttatt gcttttgtaa ccatctatat ctaataattc cattagtata 39720 tctccaattt tatttacgtt catatcctat caattccttt cggtttgttt actacgctta 39780 ttacattaca gtatcttgta tttaatgtca ataggttata cgaaagtttt ttaaataaat 39840 gttttcttac cattatatag aagaaactag aaagtacagc ttaaattaat tattataatc 39900 aatcgattta attgtataca atgcagtgta aaactaacca tttaatttga ttaaaggtat 39960 tgcatttata tatcagtctg ctataatagt atttgtaaga taaataaaag aaaagggatt 40020 gattacctat gaaagaaaca cacggatata aatttgataa aagaaaaagc atgctacaaa 40080 atgcaaaaga aaaaggcatt aaaaaacatt aaataaaaac agtgacatta taagaataaa 40140 agaaagtaga ttaaaaatag ccaaaataaa taatgatata gaaacaatta aaaaattaga 40200 aaaagaatta caagaattat ataaagagt tatagattag gttaatagcc taatcttttt 40260 ttatgttgtt tgaagcggtt aatataaagg gaaaacagcg gctgctactt aggaaaatca 40320 tagatttata cttatgatgt ttataacagt aagagagcct taatcttata ggtctatatt 40380 caacggtaat actttttagg tagtatttat cctataatac ttacttgctt atataatgta 40440 gttaaatagg caatacaagc atataaaaaa tctagggtaa aaacaaccct agctacttaa 40500 tttgattcaa aatatcctta acagcttcta atgttaaatc tgataactta atattcttat 40560 cactattagt atcaataatt acagtatagt tatctacatc atactgtata actttaagta 40620 ctgaataagt aactaactcg tattctgtat gtgtgtgata ttctatcatt gcgtacccta 40680 tacctaattc agttaagata ggttctaatg tttttctttt ctccataaac tctttaatag 40740 tatattgcat accgtcttta cttaaaaatg caggctcgtc attgtaaata taaaataat 40800 tctcaataag ttctagtaaa tcttcttctg ttccctcaca aagacttact gtataaagta 40860 attcatcgta taatttatcc tttgcttctt gaatattcat tgatattcct cctttatcct 40920 atcctaagtg tatcataagt tttaggtaat gtaaagtatt ttattttaat fạttctaa 40980 cttatccgct tcattaatcc aaccttaatt taatccctga tacttacctt ttatcataca 4...

Claims

1. An antibacterial composition comprising at least one bacteriophage having lytic activity against at least one strain of Staphylococcus aureus, wherein the at least one bacteriophage has a genome as shown in the nucleotide sequence SEQ ID NO: 1 or 4.

2. The composition according to claim 1, further comprising a pharmaceutically acceptable excipient or carrier.

3. The composition according to claim 1, which is a liquid, semi-liquid, solid or lyophilized preparation.

4. The composition according to any one of claims 1 to 3, comprising 10 1 Up to 10 12 PFU / ml of each phage.

5. Use of a composition as defined in any one of claims 1 to 4 for the preparation of a medicament for the treatment of Staphylococcus aureus infection in humans or animals.

6. Use of a composition as defined in any one of claims 1 to 4 for the preparation of a medicament for improving the condition of a human or animal infected with Staphylococcus aureus by modifying the microflora in said human or animal.

7. In vitro use of a composition as defined in any one of claims 1 to 4 for sterilizing a material.

8. A method for preparing a composition as defined in any one of claims 1 to 4, wherein the composition comprises at least two bacteriophages, the method comprising separately producing the at least two bacteriophages, and combining the bacteriophages with a suitable carrier or excipient.

9. A bacteriophage having lytic activity against a Staphylococcus aureus strain and having a genome as shown in the nucleotide sequence of SEQ ID NO: 1 or 4.

10. An isolated nucleic acid, the nucleic acid having the nucleotide sequence shown in SEQ ID NO: 1 or 4.

11. Use of a bacteriophage as defined in claim 9 or a nucleic acid as defined in claim 10 for the preparation of a medicament for the treatment of Staphylococcus aureus infections in humans or animals.

12. Use of a bacteriophage as defined in claim 9 or a nucleic acid as defined in claim 10 for the preparation of a medicament for improving the condition of a mammal infected with Staphylococcus aureus by modifying the microflora in said mammal.

13. In vitro use of a bacteriophage as defined in claim 9 or a nucleic acid as defined in claim 10 for sterilizing a material.

14. A method for determining a phage cocktail effective against a target Staphylococcus aureus strain, the method comprising: a) contacting the target Staphylococcus aureus strain or a sample containing the target Staphylococcus aureus strain separately with the following phages: (i) a phage having a genome as shown in the nucleotide sequence of SEQ ID NO: 1, and / or (ii) a phage having a genome as shown in the nucleotide sequence of SEQ ID NO: 4; b) selecting a bacteriophage showing lytic activity against the strain, c) optionally further selecting active phage that exhibit synergistic activity against said strain when combined together; and / or d) optionally further selecting active phage that do not exhibit antagonism when combined together; and / or e) optionally selecting active phage belonging to a different genus; and f) combining the selected phages.

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