A sample collection device and a sample collection method

Abstract

The embodiment of the present application discloses a sample collection device and a sample collection method. The sample collection device includes: a collection part, a detection part, and a connection part connecting the collection part and the detection part; the collection part includes a core body, the connection part includes a hollow structure, and at least part of the core body is arranged in the hollow structure; the core body is hydrophilic. The sample collection device of the present application is provided with a highly hydrophilic core body in the collection part. The core body has a large hydrophilic surface, and the sample is absorbed by the core body, which can increase the amount and efficiency of the collected sample, and the core body has a maintaining effect on the sample, so that the collection angle is not restricted.

Description

Technical Field

[0001] The present application relates to the field of medical devices, and in particular to a sample collection device and a sample collection method. Background Art

[0002] In the field of sample collection and testing, for liquid samples such as blood and saliva, conventional sample collection devices mainly use the siphon effect to absorb biological samples into the inside. Such sample collection devices have a small collection volume and a limited collection angle, resulting in low detection accuracy and inconvenient operation. Therefore, it is necessary to propose a sample collection device with a large collection volume and an unrestricted collection angle. Summary of the invention

[0003] One of the embodiments of the present specification provides a sample collection device, which includes: a collection part, a detection part, and a connecting part connecting the collection part and the detection part; the collection part includes a core body, the connecting part includes a hollow structure, and at least a part of the core body is arranged in the hollow structure; the core body is hydrophilic.

[0004] In some embodiments, the core comprises a hydrophilic fiber bundle structure, and the fiber bundle structure has gaps therein for the sample to pass through.

[0005] In some embodiments, the fiber bundle structure has adsorptivity to red blood cells in the sample.

[0006] In some embodiments, the connecting portion includes a collecting end, the collecting end is far away from the detecting portion; the collecting end has a notch, and a portion of the surface of the core is exposed from the notch.

[0007] In some embodiments, the hollow structure is provided with a first channel and a second channel, the first channel and the second channel are interconnected and pass through the connecting portion; the inner diameter of the first channel is greater than the inner diameter of the second channel.

[0008] In some embodiments, the core is disposed in the first channel, and an outer diameter of the core is greater than an inner diameter of the second channel.

[0009] In some embodiments, at least one supporting structure is disposed on the inner wall of the first channel, and the supporting structure protrudes from the inner wall of the first channel; the multiple supporting structures are in contact with the peripheral side of the core.

[0010] In some embodiments, the detection portion includes a detection cavity, and the gap of the core is connected to the detection cavity through the hollow structure.

[0011] In some embodiments, the detection portion includes a detection element disposed in the detection cavity.

[0012] In some embodiments, the detection element includes an adsorption section and a detection section which are arranged in sequence; the adsorption section is used to adsorb red blood cells in the sample; and the detection section is used to detect the sample.

[0013] In some embodiments, the detection element includes a plurality of detection pieces distributed along the radial direction of the detection cavity, and each of the plurality of detection pieces has different detection content.

[0014] In some embodiments, an operating port is provided at one end of the detection cavity away from the connecting portion, and the detection element is placed into and / or taken out of the detection cavity through the operating port; the operating port is provided with a sealing cover, and the sealing cover is detachably connected to the operating port.

[0015] In some embodiments, the detection portion includes a bracket for supporting the detection element; the bracket is connected to the inner wall of the detection cavity.

[0016] In some embodiments, the detection portion includes a buffer unit disposed between the connecting portion and the detection cavity, and the buffer unit is used to reduce a flow rate of the sample flowing toward the detection cavity.

[0017] In some embodiments, the detection part includes a connecting end connected to the connecting part, and the connecting end is provided with a limiting structure; the connecting part includes a snap-fit ​​structure, and the snap-fit ​​structure is snap-fitted with the limiting structure to limit the separation of the collection part and the detection part.

[0018] In some embodiments, the connection portion includes a stop structure, which is disposed around the circumference of the connection portion and extends radially along the connection portion, and the diameter of the stop structure is greater than the inner diameter of the connection end.

[0019] In some embodiments, the sample collection device further includes a buffer pre-storage portion, the buffer pre-storage portion including a buffer, a pre-storage cavity and a sealing sheet; the buffer is stored in the pre-storage cavity, and the sealing sheet seals the pre-storage cavity.

[0020] In some embodiments, the buffer pre-storage section further includes a guide cavity connected to the pre-storage cavity, and the sealing sheet is disposed between the pre-storage cavity and the guide cavity.

[0021] In some embodiments, the collecting portion is separately arranged from the buffer pre-storage portion, and the collecting portion enters the buffer pre-storage portion through the guiding cavity.

[0022] One of the embodiments of the present specification provides a sample collection method, the method comprising: contacting the sample through the collection end of the connecting part of the sample collection device, so that the core body absorbs and stores the sample; wherein the core body is arranged inside the connecting part, and the core body is hydrophilic; inserting the connecting part into the buffer pre-storage part of the sample collection device, so that the core body is inserted into the buffer in the buffer pre-storage part; flushing the sample from the core body into the detection part of the sample collection device through the buffer to obtain a detection result.

[0023] In some embodiments, the method further includes: connecting the connecting portion and the detecting portion.

[0024] In some embodiments, the method further includes: placing a detection element into a detection cavity of the detection portion; and covering the detection cavity with a sealing cover. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] The present application will be further described in the form of exemplary embodiments, which will be described in detail by way of the accompanying drawings. These embodiments are not restrictive, and in these embodiments, the same number represents the same structure, wherein:

[0026] Figure 1A is a front view of a sample collection device according to some embodiments of the present application;

[0027] Figure 1B is a side view of a sample collection device according to some embodiments of the present application;

[0028] Figure 2 is a cross-sectional view of a core according to some embodiments of the present application;

[0029] Figure 3 is a schematic diagram of the structure of a collection part and a connection part according to some embodiments of the present application;

[0030] Figure 4 is a cross-sectional view of a connecting portion according to some embodiments of the present application;

[0031] Figure 5A is a schematic diagram of the structure of a sample collection device according to some embodiments of the present application;

[0032] Figure 5B is a schematic structural diagram of a sample collection device from another perspective according to some embodiments of the present application;

[0033] Figure 6 is a schematic structural diagram of a buffer pre-storage unit according to some embodiments of the present application;

[0034] Figure 7It is a flowchart of a sample collection method according to some embodiments of the present application. DETAILED DESCRIPTION

[0035] Exemplary embodiments or implementations will be described in detail herein, examples of which are shown in the accompanying drawings. When the following description refers to the drawings, unless otherwise indicated, the same numbers in different drawings represent the same or similar elements. The implementations described in the following exemplary embodiments do not represent all implementations consistent with the present application. Instead, they are merely examples of devices and methods consistent with some aspects of the present application as detailed in the appended claims.

[0036] The terms used in this application are for the purpose of describing specific embodiments only and are not intended to limit this application. The singular forms "a", "said" and "the" used in this application and the appended claims are also intended to include plural forms, unless the context clearly indicates other meanings.

[0037] It should be understood that the words "first", "second" and similar words used in the specification and claims of this application do not indicate any order, quantity or importance, but are only used to distinguish different components. Similarly, words such as "one" or "an" do not indicate a quantitative limitation, but rather indicate the presence of at least one. Unless otherwise indicated, words such as "front", "rear", "lower" and / or "upper" are merely for ease of description and are not limited to one position or one spatial orientation. Words such as "include" or "comprise" and similar words mean that the elements or objects appearing before "include" or "comprises" include the elements or objects listed after "include" or "comprises" and their equivalents, and do not exclude other elements or objects.

[0038] The sample collection device of one or more embodiments of the present application can be used to collect various biological samples or chemical samples, including but not limited to liquid samples such as blood, saliva, urine, chemical solutions, enzyme solutions, and drug solutions. The sample collection device can also detect the collected samples to provide a reference for disease diagnosis, immune detection, drug testing, etc. In the embodiments of this specification, an exemplary application scenario of the sample collection device can be collecting and testing blood, which can come from the reserved blood in a blood collection tube or a blood bag, or from human blood directly obtained by a blood collection needle, such as fingertip blood collection.

[0039] In some embodiments, the sample collection device may be a collection device provided with a siphon tube, which utilizes the siphon effect of the siphon tube to absorb the sample, and transfers the sample to the detection chamber for detection. When using this sample collection device for collection, due to the limited gravitational force of the siphon tube, the amount of sample collected is small and the collection efficiency is low. In addition, since the sample will be affected by gravity, it is usually necessary to place the siphon tube horizontally or at a small angle (for example, between 0° and 10°) to increase the amount of sample collected, resulting in a limited collection angle and inconvenient operation. The sample collection device of one or more embodiments of the present specification can increase the amount and efficiency of sample collection by providing a highly hydrophilic core in the collection part, and the core absorbs the sample, and the core has a maintaining effect on the sample, so that the collection angle is not limited.

[0040] It should be understood that the application scenarios of the sample collection device of the present application are merely some examples or embodiments of the present application. For ordinary technicians in this field, the present application can also be applied to other similar scenarios based on these drawings without any creative work.

[0041] Figure 1A It is a front view of the sample collection device 1 shown in some embodiments of the present application. Figure 1B It is a side view of the sample collection device 1 according to some embodiments of the present application.

[0042] See also Figure 1A and Figure 1B The embodiment of the present specification provides a sample collection device 1, which includes a collection part 10, a detection part 20, and a connection part 30 connecting the collection part 10 and the detection part 20. The collection part 10 can be used to collect samples, and the sample can be a collection object such as blood, saliva, urine, chemical solution, enzyme solution, etc. The detection part 20 can be used to detect various indicators of the sample. In some embodiments, the indicators may include but are not limited to medical indicators, biological indicators or chemical indicators. For example, the sample can be blood, and the detection part 20 can detect indicators such as serum lipids, trace elements, antibiotics, viral antibodies, and pH in the blood sample. For another example, the sample can be saliva, and the detection part 20 can detect indicators such as enzymes, polysaccharides, alcohol, viral antibodies, etc. in the saliva sample.

[0043] In some embodiments, the collection portion 10 includes a core 110, and the connection portion 30 includes a hollow structure, and at least a portion of the core 110 is disposed in the hollow structure of the connection portion 30, that is, the hollow structure of the connection portion 30 can accommodate and fix the core 110, wherein at least a portion of the core 110 may refer to the entire core 110 or a portion of the core 110. In some embodiments, the entire core 110 is disposed in the hollow structure of the connection portion 30. In some embodiments, a portion of the core 110 is disposed in the hollow structure of the connection portion 30, and another portion of the core 110 is exposed outside the hollow structure of the connection portion 30. In some embodiments, the core 110 can be used to absorb samples. In some embodiments, the core 110 can also be used to store samples. For more details about the collection portion 10, please refer to Figure 3 and Figure 4 and its related description.

[0044] In some embodiments, the core 110 is hydrophilic, and hydrophilicity may refer to the property of being able to attract water molecules. The hydrophilic core 110 has a great liquid surface tension for water molecules, so that water molecules can be absorbed and retained on the core 110. In layman's terms, the core 110 is easily wetted by the water in the sample. In some embodiments, the hydrophilicity of the core 110 may include the hydrophilicity of the outer surface of the core 110, and may also include the hydrophilicity of the interior of the core 110. In some embodiments, the hydrophilicity of the core 110 can be obtained by special process treatment. In some embodiments, the hydrophilicity of the core 110 can also be obtained by the properties of the material itself. In some embodiments, the hydrophilicity of the core 110 can also be obtained by designing the internal structure of the core 110. The hydrophilicity of the core 110 can be used to enhance the attraction of the core 110 to water molecules. Under the action of this attraction, the water molecules will quickly diffuse from the wet area of ​​the core 110 to the dry area, which is manifested as the process of the sample gradually soaking the core 110. The hydrophilicity of the core 110 can increase the amount of sample absorbed to meet the detection requirements of the detection unit 20, and the attraction of the core 110 to water molecules can increase the speed of absorbing water molecules and improve the sample collection speed; not only that, by utilizing the hydrophilicity of the core 110, after the core 110 absorbs the sample, the sample stored on the core 110 has strong stability and is less affected by gravity, which can not only prevent the sample from flowing back, but also allow the collection unit 10 to absorb the sample at any angle in space, making the sample collection operation simpler and more casual. For more details about the core 110, please see Figure 2 and its related description.

[0045] In some embodiments, the detection unit 20 is connected to the collection unit 10 via the connection unit 30. In some embodiments, the connection unit 30 can be detachably connected to the detection unit 20, and the connection method includes but is not limited to snap-on, threaded connection, interference fit, etc. In some embodiments, the connection unit 30 can be non-detachably connected to the detection unit 20, and the connection method includes but is not limited to one-piece molding, adhesive connection, etc. In some embodiments, the detection unit 20 may include a detection cavity 210 for accommodating the sample when the sample is detected. For more details about the detection unit 20 and the detection cavity 210, please refer to Figure 5A and Figure 5B and its related description.

[0046] Figure 2 is a cross-sectional view of the core 110 according to some embodiments of the present application. Figure 2 The arrangement of the fiber bundle structure and the arrangement of the gaps 111 are for reference only. Figure 2 The fiber bundle arrangement and density of the fiber bundle structure are not limited.

[0047] See also Figure 2 In some embodiments, the core 110 includes a hydrophilic fiber bundle structure, which can be a structure in which a large number of single fibers 112 are bonded to each other and solidified into a bundle. The material selection of the fiber bundle structure can be selected from materials with good biocompatibility and not easy to damage the tissue cells in the sample, such as polyester fiber, dacron, medical cotton, etc. This material can reduce the damage of the core 110 material to the sample and improve the stability of the sample being absorbed. Due to the good biocompatibility of the material, the cell membrane of the tissue cells can be prevented from rupturing so that the substances in the tissue cells affect the test results. In some embodiments, the fiber bundle structure can be treated by chemical or physical methods to enhance its biocompatibility and other properties. For example, almost all the fibers 112 in the treated fiber bundle structure can extend along the axial direction of the core 110. For another example, the treated fiber bundle structure can have a cross-section of equal density, and so on.

[0048] In some embodiments, the core 110 can be modified to obtain hydrophilicity. In some embodiments, the modification refers to giving the core 110 new properties, such as hydrophilicity, while maintaining the original properties of the core 110 or the material of the core 110. In some embodiments, the single fiber 112 of the core 110 can be surface treated or cross-sectionally treated to obtain hydrophilicity, such as processing micro-concave and convex on the surface of the single fiber 112, and for example, treating the cross section of the single fiber 112 into an L-type or C-type, which can increase the surface area of ​​the single fiber 112, thereby improving the hydrophilicity. In some embodiments, hydrophilicity can include attraction to water molecules. In some embodiments, different numbers and types of hydrophilic groups can be added to the core 110 to enhance the attraction to water molecules, thereby obtaining hydrophilicity, for example, adding hydrophilic group components such as amino, hydroxyl, carboxyl, and amide groups to the surface or structure of the fiber 112 to increase its hydrophilicity. In some embodiments, hydrophilicity can also include the ability to maintain water molecules, also known as water locking ability. In some embodiments, hydrophilic groups and hydrophobic groups can be added to the material of the core 110 at the same time to form a cross-linked mesh-like polymer structure. Due to the hydration of water molecules by the hydrophilic groups, the attraction of the core 110 to water molecules can be improved, and the hydrophobic groups can make the water molecules entering the mesh lose their activity due to polarity, so that the water molecules are maintained inside the material of the core 110, and the water-locking ability of the core 110 is improved. By providing a hydrophilic material with a cross-linked mesh-like polymer structure, the water absorption capacity of the core 110 can be made to reach more than 100 times its own weight, greatly improving the attraction and water-locking ability of the core 110.

[0049] In some embodiments, see Figure 2 After the core 110 is modified, not only its surface has high hydrophilicity, but also each fiber 112 in the fiber bundle structure has hydrophilicity, so that the total hydrophilic surface area of ​​the entire core 110 is increased. Among them, the total hydrophilic surface area can be the sum of the surface areas of all single fibers 112, thereby increasing the attraction of the core 110 to water. In some embodiments, the fiber bundle structure has a gap 111 for the sample to pass through, and the gap 111 can be composed of the gap between the fiber 112 and the fiber 112, and the sample moves from the gap 111. The gap 111 inside the fiber bundle structure can increase the hydrophilic area of ​​the core 110, so that the sample is more easily absorbed onto the core 110. In some embodiments, since the core 110 has a strong attraction and water locking ability for water molecules, the core 110 can absorb the sample and store the sample in the gap 111 of the core 110, and these samples can overcome gravity and remain in the core 110 under the action of the hydrophilicity of the core 110. In some embodiments, the core 110 can aspirate and store a sample volume of up to 60 μL to 70 μL.

[0050] In some embodiments, in the fiber bundle structure, the volume ratio of the void 111 to the fiber bundle structure can be set in different ranges according to requirements to obtain different effects. For example, the volume ratio of the void 111 to the fiber bundle structure can be in the range of 1%-10%, for example, the volume ratio of the void 111 to the fiber bundle structure can be 3%, 6%, 7%, 8% or 9%, etc.

[0051] In some embodiments, the volume ratio of the voids 111 to the fiber bundle structure is relatively low, for example, the volume ratio of the voids 111 to the fiber bundle structure is in the range of 1%-5%, indicating that the fiber bundle structure in the core 110 is relatively dense (i.e., the gaps between the fibers 112 and the fibers 112 are small), which will produce appropriate resistance to the sample flowing on the core 110, slowing down the flow rate of the sample through the voids 111, thereby playing a buffering role for the sample. In addition, for the core 110 with a relatively low volume ratio of the voids 111 to the fiber bundle structure, its performance of maintaining the sample inside is relatively strong, which can prevent the sample from flowing back.

[0052] In some embodiments, the volume ratio of the void 111 to the fiber bundle structure is relatively high. For example, the volume ratio of the void 111 to the fiber bundle structure is in the range of 5%-10%, indicating that the fiber bundle structure in the core 110 is relatively sparse (i.e., the gaps between fibers 112 and 112 are larger). The resistance to the flow of the sample on the core 110 is small, which can increase the speed at which the core 110 absorbs the sample, so that the sample can quickly reach the detection chamber 210, thereby improving the detection efficiency.

[0053] The volume ratio of the void 111 to the fiber bundle structure in the embodiment of the present disclosure should not be too high or too low. If the volume ratio of the void 111 to the fiber bundle structure is too low, the flow resistance generated to the sample will be too large, which may reduce the collection efficiency and hinder the detection components in the sample (such as plasma in a blood sample), or even damage the tissue cells in the sample. If the volume ratio of the void 111 to the fiber bundle structure is too high, the total hydrophilic surface area of ​​the core 110 will be reduced too much, thereby reducing the amount of sample absorbed by the core 110. Preferably, the volume ratio of the void 111 to the fiber bundle structure is in the range of 5%-6%.

[0054] In other embodiments, the volume ratio of the gap 111 to the fiber bundle structure may also be in other ranges or may be set arbitrarily, and this specification does not impose any limitation on this.

[0055] In some embodiments, colored components in certain samples may interfere with the test results, so the fiber bundle structure can be processed to have the ability to adsorb colored components or non-test components in the sample. Taking a blood sample as an example, the red blood cells in the blood sample may affect the test results, so the fiber bundle structure has adsorption properties for the red blood cells in the sample. During the collection process, the red blood cells are retained in the fiber bundle structure, and the serum continues to flow into the test chamber 210 for detection.

[0056] In some embodiments, the core 110 may be modified to obtain the property of absorbing red blood cells. For example, groups such as hemagglutinin that can absorb red blood cells may be added to the cellulose 112 structure of the core 110, so that the red blood cells can bind to the hemagglutinin and other groups and remain in the core 110.

[0057] In some embodiments, the volume ratio of the gap 111 to the fiber bundle can be in the range of 5%-10%, so that the core 110 has a better property of adsorbing red blood cells. The volume ratio of the gap 111 to the fiber bundle should not be too high or too low. If the volume ratio of the gap 111 to the fiber bundle is too high, it means that the amount of fiber 112 in the core 110 is small, and the gap 111 is large, then the amount of groups such as hemagglutinin is also correspondingly small, which will reduce the adsorption amount of red blood cells. In addition, the gap 111 between the fibers 112 is large, which easily causes the red blood cells to be washed to the detection part 20 before they are completely combined with the groups such as hemagglutinin, thereby reducing the filtering effect of the core 110 on red blood cells. If the volume ratio of the gap 111 to the fiber bundle is too low, it means that there are more fibers 112 in the core 110 and the gap 111 is smaller. Red blood cells are likely to clog the gap 111, affecting the speed at which the core 110 absorbs the sample. In addition, red blood cells are easily squeezed and damaged when entering the gap of the core 110, causing the substances in the red blood cells to be washed into the detection part 20, affecting the detection results.

[0058] Figure 3 is a schematic diagram of the structure of the collecting part 10 and the connecting part 30 according to some embodiments of the present application; Figure 4 is a cross-sectional view of the connecting portion 30 according to some embodiments of the present application.

[0059] In some embodiments, see Figure 3 The connection part 30 may be configured as a hollow columnar structure, that is, the connection part 30 may include a hollow structure, and the hollow structure may include but is not limited to cylindrical, prism-shaped, etc. In some embodiments, the connection part 30 includes a collection end 310 and an assembly end 320, the collection end 310 is away from the detection part 20, and may be an end connected to the collection part 10; the assembly end 320 may be an end connected to the detection part 20.

[0060] In some embodiments, the collection end 310 has a notch 311, and part of the surface of the core 110 is exposed from the notch 311, thereby increasing the area of ​​the core 110 exposed outside the collection end 310. When collecting samples, this setting can increase the contact area between the core 110 and the sample, thereby improving the sample collection efficiency. The part of the collection end 310 other than the notch 311 can provide support for the core 110 to prevent the deformation of the core 110 from affecting the collection effect. In some embodiments, the orthographic projection (referring to the projection along the direction of looking directly at the notch) of the notch 311 of the collection end 310 can be an arc, a triangle, etc., and the number of notches 311 can be N, where N is a natural number.

[0061] In some embodiments, see Figure 4 , the hollow structure of the connection part 30 may include a first channel 330 and a second channel 340, the first channel 330 and the second channel 340 are interconnected and penetrate the connection part 30, so that an inlet 312 for allowing the sample to flow in and an outlet 321 for allowing the sample to flow out are formed on the connection part 30. In some embodiments, the inlet 312 of the connection part 30 is located at the collection end 310, and the outlet 321 of the connection part 30 is located at the assembly end 320. In some embodiments, the first channel 330 may be close to the collection end 310, one end of the first channel 330 forms the inlet 312 of the connection part 30, and the other end is connected to the second channel 340; the second channel 340 may be close to the assembly end 320, one end of the second channel 340 forms the outlet 321 of the connection part 30, and the other end is connected to the first channel 330. In some embodiments, the first channel 330 may be used to install the core 110, and the second channel 340 may be used as a hollow channel for guiding flow. In some embodiments, the axes of the first channel 330 and the second channel 340 may be straight, curved, etc.

[0062] In some embodiments, the inner diameter of the first channel 330 is greater than the inner diameter of the second channel 340. The first channel 330 has a larger inner diameter, which can accommodate a core 110 with a larger cross-section, which helps to increase the rate of collecting samples. The second channel 340 has a smaller inner diameter, which is more likely to produce a capillary phenomenon, so that the sample flows from the core 110 toward the outlet 321 under the capillary action.

[0063] In some embodiments, the core 110 is disposed in the first channel 330, and the outer diameter of the core 110 is greater than the inner diameter of the second channel 340. Thus, since the inner diameter of the first channel 330 is greater than the inner diameter of the second channel 340, a step 350 is formed at the connection between the first channel 330 and the second channel 340, and the end of the core 110 can abut against the step 350 to limit the displacement of the core 110 toward the second channel 340.

[0064] In some embodiments, at least one support structure 360 ​​is disposed on the inner wall of the first channel 330, and the support structure 360 ​​protrudes from the inner wall of the first channel 330, and the support structure 360 ​​is used to support and limit the core 110. In some embodiments, the protruding height of the support structure 360 ​​from the inner wall of the first channel 330 is less than the height of the step 350 from the inner wall of the first channel 330, so as to accommodate the core 110 having an inner diameter greater than that of the second channel 340.

[0065] In some embodiments, the support structure 360 ​​may be configured as a long protrusion, for example, the long protrusion may extend along the axial direction of the first channel 330, or the long protrusion may extend obliquely relative to the side wall of the first channel 330. In some embodiments, the support structure 360 ​​may be configured as a plurality of convex points arranged at intervals. In some embodiments, the support structure 360 ​​may be configured as an annular protrusion, for example, the annular protrusion may be a closed circular ring extending in the circumferential direction, or the annular protrusion may be a spiral ring extending spirally along the inner wall of the first channel 330. It should be noted that the configuration of the support structure 360 ​​in the embodiments of the present disclosure does not constitute a limitation on the embodiments of the present specification, and its configuration may be one or a combination of long protrusions, convex points, annular protrusions or other arbitrary protrusion shapes.

[0066] In some embodiments, there are multiple support structures 360, and multiple support structures 360 abut against the peripheral side of the core 110. In some embodiments, the arrangement of the support structures 360 enables the peripheral side of the core 110 to form a gap with the inner wall of the first channel 330, for example, four long protrusions are arranged at equal intervals along the circumferential direction. The gap formed between the core 110 and the inner wall of the first channel 330 can reduce the contact area between the core 110 and the inner wall, thereby reducing the friction resistance of the core 110 in the process of assembling it into the first channel 330, making it easier for the core 110 to be inserted into the first channel 330. In addition, the gap formed between the core 110 and the inner wall of the first channel 330 can avoid adhesion and blockage caused by the sample entering. In addition, the core 110 will expand and deform slightly after absorbing the sample, and the gap between the core 110 and the inner wall of the first channel 330 provides a deformation space for the expansion of the core 110.

[0067] In some embodiments, the connection portion 30 may be made of a transparent material, such as transparent plastic, glass, etc., so as to facilitate observation of the condition of the core 110 in the first channel 330, such as observation of the degree of sample infiltration into the core 110, expansion and deformation of the core 110, etc. In some embodiments, the connection portion 30 may be made of a non-transparent material, such as non-transparent plastic, metal material, etc.

[0068] Figure 5A is a schematic diagram of the structure of a sample collection device 1 according to some embodiments of the present application; Figure 5BIt is a schematic structural diagram of the sample collection device 1 from another perspective according to some embodiments of the present application.

[0069] In some embodiments, the detection part 20 includes a detection cavity 210, and the gap 111 of the core 110 is connected to the detection cavity 210 through the hollow structure of the connection part 30. In this way, after the sample is sucked into the hollow structure of the connection part 30 by the core 110, it can enter the detection cavity 210 from the hollow structure.

[0070] In some embodiments, the detection unit 20 also includes a detection element 220 disposed in the detection cavity 210. The detection cavity 210 may be a hollow cavity capable of accommodating the detection element 220. In some embodiments, the detection cavity 210 may provide a sealed environment for the detection element 220 to prevent substances in the external environment from contaminating the sample and the detection element 220 and affecting the detection results, for example, to prevent external humidity, bacteria, dirt and other substances from entering the detection cavity 210 to ensure detection accuracy. In some embodiments, the detection unit 20 may include a housing 230, which defines the detection cavity 210 of the detection unit 20. In some embodiments, the shape of the housing 230 may include, but is not limited to, a cylindrical tube, a prismatic tube, or an irregular tube, etc. In some embodiments, the housing 230 may be made of a transparent material to facilitate observation of the detection results of the detection element 220. In some embodiments, the detection cavity 210 can be connected to the hollow structure of the connecting portion 30 (for example, the outlet 321 of the connecting portion 30), so that the gap 111 of the core body 110 is connected to the detection cavity 210 through the hollow structure of the connecting portion 30, thereby realizing the sample transportation from the collection portion 10 to the detection portion 20.

[0071] In some embodiments, an operation port is provided at one end of the detection cavity 210 away from the connection portion 30, and the detection element 220 is placed in and / or taken out of the detection cavity 210 from the operation port. In some embodiments, a cover 240 is provided at the operation port, and the cover 240 is detachably connected to the operation port, and the detachable connection method includes but is not limited to a threaded connection, a snap connection, and the like, to open or close the operation port. In some embodiments, a slot may be provided on the surface of the cover 240 located inside the detection cavity 210, and the slot is used to fix and install the detection element 220.

[0072] In some embodiments, the detection element 220 may be an element for detecting a sample and displaying the detection result. For example, in a blood sample detection, a biological enzyme capable of biologically or chemically reacting with the blood sample is disposed on the detection element 220. When the blood sample reaches the detection element 220, the biological enzyme reacts with the blood sample to display a color signal, and the detection personnel can judge whether there is a detection substance in the blood sample based on the color signal.

[0073] In some embodiments, the detection element 220 includes an adsorption section 221 and a detection section 222 sequentially arranged along the axial direction of the detection cavity 210. In some embodiments, the adsorption section 221 is located at one end close to the connection part 30. After the core 110 in the connection part 30 collects the sample, most of the non-detection components or colored components in the sample are retained in the core 110, but a small amount of non-detection components or colored components may still reach the detection cavity 210, and the adsorption section 221 can adsorb the non-detection components or colored components again. For example, for a blood sample, the red blood cells in the blood will interfere with the color display of the detection element 220, so the core 110 is configured to be able to adsorb and retain a large number of red blood cells, and the adsorption section 221 can also be used to adsorb the red blood cells in the sample, so that even if a small amount of red blood cells enter the detection cavity 210, they can be retained in the adsorption section 221. Through the cooperation of the core 110 and the adsorption section 221, the non-detection components or colored components in the sample can be avoided to the greatest extent from entering the detection section 222, thereby improving the detection accuracy of the detection element 220.

[0074] In some embodiments, the detection section 222 is used to detect samples. In some embodiments, the detection section 222 is provided with substances that can react with samples, such as chemical reagents, reaction enzymes, etc. These substances can cover the entire area or a local area of ​​the detection section 222, and the present disclosure does not limit this. In some embodiments, the detection elements can be used to detect serum lipids, trace elements, antibiotics, pH, etc., respectively, and the embodiments of this specification do not limit this.

[0075] In some embodiments, the detection element may include multiple (two or more) detection parts, and the detection part can detect one or more detection contents of the sample and display the detection results. In some embodiments, the detection part can be arranged along the axial direction of the detection cavity 210. In some embodiments, when it is necessary to detect a detection content of the sample, a detection part can be arranged in the detection cavity 210. An indicator can be arranged on the detection part, and the indicator is composed of a substance that can react with the sample. The indicator can be formed into a linear, two-dimensional graphic, text, number or other symbols, and the embodiments of this specification are not limited to this. In some embodiments, the indicator of the detection part can be an indicator line, and different indicator lines can show different colors after encountering different components in the sample to obtain the detection result.

[0076] In some embodiments, when multiple (two or more) test contents of the sample need to be detected, a detection member can be set in the detection chamber 210. Multiple indicators can be set on the detection member, each indicator can detect different test contents, so that multiple test results can be obtained using one sample and one detection member, thereby improving the efficiency of the test. In some embodiments, the number of indicator lines of the detection member can be 1 to 3 indicator lines.

[0077] In some embodiments, when multiple detection contents of the sample need to be detected, multiple detection parts can also be set in the detection cavity 210. In some embodiments, the detection element 220 includes multiple detection parts distributed along the radial direction of the detection cavity 210, and the detection parts are radially distributed in the detection cavity 210, without overlapping and blocking each other, so as to facilitate the observation of the detection results on the detection parts. In some embodiments, on a cross section perpendicular to the axis of the detection cavity 210, each of the multiple detection parts can extend from the peripheral side of the detection cavity 210 to the axial position of the detection cavity 210. For example, when there are three detection parts, the three detection parts can be distributed in three equal parts along the radial direction of the detection cavity 210, and on a cross section perpendicular to the axis of the detection cavity 210, each detection part extends from the three equal parts position of the peripheral side of the detection cavity 210 to the axial position of the detection cavity 210. In some embodiments, the detection content of each of the multiple detection elements is different. For example, an indicator is set on each detection element, and each detection element is used to detect one detection content of the sample. For another example, multiple indicators are set on each detection element, and each detection element is used to detect multiple detection contents of the sample. In this way, limited detection elements can be used to detect as many detection contents as possible, thereby improving detection efficiency.

[0078] In some embodiments, the detection element 220 further includes a connecting section 223, one end of which is connected to the detection section 222, and the other end of which extends to the end of the detection cavity 210 away from the connecting portion 30. In some embodiments, one end of the connecting section 223 is connected to the detection section 222, and the other end can be inserted into the slot of the cover 240. In some embodiments, the detection element 220 may also not include the connecting section 223, and the adsorption section 221 of the detection element 220 may be fixed by the bracket 250 described below, and the detection section 222 is supported in the detection cavity 210 by the adsorption section 221.

[0079] In some embodiments, the adsorption section 221, the detection section 222 and the connecting section 223 of the detection element 220 can be integrally formed. In some embodiments, the thickness or hardness of the adsorption section 221 and the connecting section 223 can be appropriately increased to provide greater support force, so that the adsorption section 221 and the connecting section 223 are conveniently fixed in the detection cavity 210.

[0080] In some embodiments, the detection unit 20 includes a bracket 250 for supporting the detection element 220. In some embodiments, a slot may be provided on the bracket 250, and the adsorption section 221 of the detection element 220 may be inserted into the slot. In some embodiments, the bracket 250 is connected to the inner wall of the detection cavity 210, so that the stability of the bracket 250 can be maintained. When the sample collection device 1 is placed in different orientations, the bracket 250 remains in the detection cavity 210 without shaking. In some embodiments, the bracket 250 can be connected to the inner wall of the detection cavity 210 along the axial direction of the detection cavity 210.

[0081] In some embodiments, the bracket 250 may be a hollow cylinder, with a slot at one end of the bracket 250 and an opening at the other end, and the adsorption section 221 of the detection element 220 is inserted from the slot into the inside of the bracket 250 and extends to the opening. In some embodiments, an observation window 251 may be provided on the bracket 250, through which the adsorption effect of the sample on the adsorption section 221 may be observed.

[0082] In some embodiments, the detection part 20 includes a buffer unit 260 connected to the detection cavity 210, and the buffer unit 260 is used to reduce the flow speed of the sample. After the sample is collected by the core 110, the sample can be flushed into the detection cavity 210 through the buffer 410. Under the action of the flushing force, the sample flows to the detection cavity 210 at a faster speed. The buffer unit 260 can slow down the speed of the sample flowing to the buffer cavity to prevent the sample from splashing into the detection cavity 210 after rushing out from the second channel 340 of the connection part 30. For more information about the buffer 410, please refer to Figure 6 Description. In some embodiments, the buffer unit 260 can be constructed as a columnar buffer pad, and the buffer unit 260 can be arranged between the connecting portion 30 and the bracket 250. In some embodiments, the buffer unit 260 can be made of fiber bundles, polyester fibers 112, cotton and other materials. In other embodiments, the detection unit 20 may not be provided with the buffer unit 260, but by setting the volume ratio of the void 111 and the fiber bundle structure in the core body 110, the core body 110 itself can achieve the effect of buffering the sample. The specific setting method of the volume ratio of the void 111 and the fiber bundle structure can refer to the description elsewhere in this specification and will not be repeated here.

[0083] In some embodiments, when a buffer unit 260 is provided in the detection part 20, the bracket 250 can extend along the axial direction of the detection cavity 210 to an end of the buffer unit 260 away from the connection part 30. In some embodiments, the extension length of the bracket 250 in the detection cavity 210 along the axial direction of the detection cavity 210 can also be set arbitrarily, and the embodiments of this specification are not limited to this.

[0084] In some embodiments, the detection part 20 includes a connection end 270 connected to the connection part 30, and the connection end 270 is provided with a limiting structure, and the limiting structure is used to limit the displacement of the connection part 30 out of the detection cavity 210. In some embodiments, the limiting structure can be provided on the inner wall of the connection section 223. In some embodiments, the connection part 30 includes a snap-fit ​​structure 370, and the snap-fit ​​structure 370 is snap-fitted with the limiting structure, thereby limiting the separation of the collection part 10 and the detection part 20 from each other.

[0085] In some embodiments, the limiting structure may be a limiting step (not shown in the figure), and the snap-fit ​​structure 370 may be a barb having a certain elastic deformation capability. During the insertion of the connecting portion 30 into the detection cavity 210, the barb is radially compressed. After the barb passes through the limiting step, it expands radially under the action of the elastic restoring force and snaps onto the limiting step, thereby limiting the connecting portion 30 from being separated from the detection cavity 210.

[0086] In some embodiments, the inner diameter of the connection end 270 of the detection cavity 210 may be smaller than the inner diameter of the other parts of the detection cavity 210 to form a limiting step that matches the snap-fit ​​structure 370 and makes the connection end 270 more closely matched with the collection part 10. The inner diameter of the other parts of the detection cavity 210 is larger than the inner diameter of the connection end 270, which can increase the volume of the detection cavity 210 and facilitate the accommodation of the detection element 220.

[0087] In some embodiments, the connection portion 30 includes a stopper structure 380, the diameter of which is greater than the inner diameter of the connection end 270. When the connection portion 30 is inserted into the connection end 270, the stopper structure 380 abuts against the outside of the entrance 312 of the connection end 270 to form a stopper, preventing the connection portion 30 from continuing to move into the connection end 270. In some embodiments, the connection portion 30 includes a stopper structure 380, which is disposed around the circumference of the connection portion 30 and extends in the radial direction of the connection portion 30. The stopper structure 380 may be an annular flange protruding from the connection portion 30, or may be a bump, etc.

[0088] In some embodiments, the connecting portion 30 is engaged with the limiting structure of the connecting end 270 by setting a snap-fit ​​structure 370 to limit the connecting portion 30 from being separated from the connecting end 270. At the same time, the connecting portion 30 is blocked at the entrance 312 of the connecting end 270 by setting a stop structure 380 to limit the connecting portion 30 from continuing to enter the connecting end 270. By cooperating with the snap-fit ​​structure 370 and the stop structure 380, the displacement of the connecting portion 30 along the axial direction of the detection cavity 210 can be limited, so that the connecting portion 30 is fixed to the connecting end 270.

[0089] In some embodiments, a reinforcing rib 390 may be further provided on the connecting portion 30 . The reinforcing rib 390 is provided in the area where the stop structure 380 intersects with the outer surface of the connecting portion 30 . The reinforcing rib 390 is used to strengthen the strength of the stop structure 380 and the connecting portion 30 .

[0090] In some embodiments, the sample collected by the sample collection device 1 can be obtained from the collection object (for example, the person being tested). Taking fingertip blood collection as an example, the fingertip is pierced with a blood collection device, and the core 110 can directly absorb the blood from the fingertip at any angle. Since the core 110 has a strong hydrophilicity, even if the amount of blood sample collected from the fingertip is small, it can be continuously absorbed into the core 110. In some embodiments, after the core 110 absorbs the blood sample, the blood sample can be stored in the core 110. Since the core 110 has extremely strong hydrophilicity and water locking ability, the blood sample is retained in the core 110 after entering the core 110, and will not flow out of the core 110 due to gravity. In some embodiments, when the sample collection device 1 is applied to fingertip blood collection, due to the hydrophilicity of the core 110, the blood collection volume of the sample collection device 1 can be as high as 60 microliters to 70 microliters.

[0091] Figure 6 It is a schematic structural diagram of the buffer pre-storage unit 40 according to some embodiments of the present application.

[0092] In some embodiments, see Figure 6 The sample collection device 1 also includes a buffer pre-storage section 40, which includes a buffer 410, a pre-storage cavity 420 and a sealing sheet 430. The buffer 410 is used to provide power for the sample stored on the core 110 to flow to the detection cavity 210. The buffer 410 is stored in the pre-storage cavity 420, and the sealing sheet 430 seals the pre-storage cavity 420 to store the buffer 410.

[0093] In some embodiments, the buffer 410 may include, but is not limited to, phosphate buffer, organic acid buffer, borate buffer, and other solutions. The buffer 410 meets the requirements of mixing and slow-release of the sample, and has little interference with the components in the sample, is not prone to chemical precipitation, and does not affect the pH of the sample. The embodiments of this specification do not limit the selection of the buffer 410.

[0094] In some embodiments, the pre-storage chamber 420 may be provided at the bottom of the buffer pre-storage section 40 for storing the buffer 410. In some embodiments, the sealing sheet 430 blocks the top of the pre-storage chamber 420 and is configured as a closed storage space with the pre-storage chamber 420, so that when the buffer pre-storage section 40 is placed in any orientation, the buffer 410 will not flow out of the pre-storage chamber 420. In some embodiments, the sealing sheet 430 may be made of a material that can be broken when subjected to a certain pressure (e.g., 100 MPa), so that the collection section 10 can pierce the sealing sheet 430 after being inserted into the buffer pre-storage section 40, and absorb the buffer 410. In some embodiments, the sealing sheet 430 may be made of a material that is not easy to break, but the connection strength between the sealing sheet 430 and the top of the pre-storage chamber 420 is weak, and it is easy to separate from the top of the pre-storage chamber 420 when subjected to a certain pressure (e.g., 100 MPa), so that the sealing sheet 430 is pressed into the pre-storage chamber 420, so that the collection section 10 can absorb the buffer 410.

[0095] In some embodiments, the buffer pre-storage part 40 further includes a guide cavity 440 connected to the pre-storage cavity 420, and the collection part 10 can slide along the guide cavity 440 into the pre-storage cavity 420. In some embodiments, when the collection part 10 is fully inserted into the buffer pre-storage part 40, the guide cavity 440 can accommodate a portion of the detection part 20, and the guide cavity 440 can fit with at least a portion of the outer wall of the detection part 20. In some embodiments, a guide groove or a guide protrusion can be provided on the inner wall of the guide cavity 440 to guide the collection part 10. In some embodiments, a sealing sheet 430 is provided between the pre-storage cavity 420 and the guide cavity 440.

[0096] In some embodiments, the collecting part 10 is separately arranged from the buffer pre-storage part 40, and the core body 110 and the connecting part 30 can enter the buffer pre-storage part 40 through the guiding cavity 440. When the core body 110 and the connecting part 30 are guided to the sealing sheet 430 by the guiding cavity 440, the collecting part 10 can continue to be pressed down to make the sealing sheet 430 invalid, and the core body 110 enters the pre-storage cavity 420 and absorbs the buffer 410.

[0097] In some embodiments, the collecting portion 10 may be temporarily stored in the buffer pre-storage portion 40 to facilitate matching packaging. At this time, the collecting portion 10 is only inserted into the guiding cavity 440 and does not continue to apply pressure to the sealing sheet 430.

[0098] In some embodiments, the sample collection device 1 further comprises a protective cap, which is formed into a cylindrical shape with an open end and a closed end, and the collection part 10 is inserted into the protective cap from the open end, and the protective cap can completely cover the collection part 10. In some embodiments, the open end of the protective cap can be detachably engaged with the outer surface of the detection part 20. In some embodiments, the open end of the protective cap can be detachably engaged with the stop structure 380 of the collection part 10.

[0099] In some embodiments, a limiting protrusion is formed on the outer wall of the protective cap, and a limiting groove adapted to the limiting protrusion is formed on the inner wall of the guide cavity 440. After the collecting part 10 is inserted into the protective cap, the protective cap can be inserted into the guide cavity 440. At this time, the limiting protrusion and the limiting groove cooperate to limit the insertion depth of the protective cap into the guide cavity 440, preventing the protective cap from contacting the sealing sheet 430, thereby preventing the sealing sheet 430 from failing.

[0100] In some embodiments, after the collection part 10 collects the sample, it is inserted into the buffer pre-storage part 40, and the collection part 10 pierces the sealing sheet 430 so that the collection end 310 of the collection part 10 is inserted into the buffer 410. As the core body 110 is inserted into the pre-storage part 40, the space inside the pre-storage part 40 is reduced, causing the buffer 410 to flow from the gap 111 of the core body 110 to the detection cavity 210, thereby flushing the sample from the core body 110 into the detection cavity 210.

[0101] Figure 7 It is a flowchart of a sample collection method according to some embodiments of the present application.

[0102] See also Figure 7 In some embodiments, the sample collection method may include process 700. In some embodiments, process 700 may be performed by a detection personnel and includes the following steps:

[0103] Step 710: contact the sample through the collection end of the connecting part of the sample collection device, so that the core absorbs and stores the sample.

[0104] In some embodiments, the connecting portion 30 of the sample collection device 1 has a hollow structure, and the core 110 can be disposed in the hollow structure, and the core 110 has hydrophilicity. The specific structures of the sample collection device 1, the connecting portion 30, and the core 110 can be found in the description elsewhere in this specification, and will not be repeated here.

[0105] In some embodiments, the tester can directly contact the sample to be collected through the collection end 310 of the connection part 30, so that the core 110 exposed at the notch 311 of the collection end 310 contacts the sample, so that the core 110 directly absorbs the sample at any angle. In some embodiments, after the core 110 absorbs the sample, the sample can be stored in the core 110 due to the hydrophilicity of the core 110.

[0106] In some embodiments, in order to facilitate packaging and transportation, the connecting part 30 and the detecting part 20 can be placed separately before use. Before using the sample collection device 1 for sampling, the connecting part 30 needs to be assembled to the detecting part 20, that is, the sample collection method also includes: connecting the connecting part 30 and the detecting part 20.

[0107] In some embodiments, the inspector can insert the assembly end 320 of the connecting part 30 into the connecting end 270 of the detection cavity 210 so that the snap-fit ​​structure 370 of the connecting part 30 is snapped into the limiting structure in the detection cavity 210 , thereby connecting the connecting part 30 to the detection part 20 .

[0108] In some embodiments, the detection element 220 and the detection part 20 can be placed separately before use. Before using the sample collection device 1 for sampling, the detection personnel can select the corresponding detection element 220 according to the items to be detected, and then assemble the detection element 220 into the interior of the detection part 20, that is, the sample collection method also includes: placing the detection element 220 into the detection cavity 210; and covering the detection cavity 210 with the sealing cover 240.

[0109] In some embodiments, the testing personnel can insert the adsorption section 221 of the testing element 220 into the card slot of the bracket 250 in the testing cavity 210, and insert the connection section 223 of the testing element 220 into the card slot of the cover 240. Then, the testing personnel can put the bracket 250 into the testing cavity 210, so that the bracket 250 is placed close to the collection part 10. Finally, the testing personnel covers the testing cavity 210 with the cover 240.

[0110] Step 720: insert the connecting portion into the buffer pre-storage portion of the sample collection device, so that the core body is inserted into the buffer in the buffer pre-storage portion.

[0111] In some embodiments, the collecting part 10 is inserted into the buffer pre-storage part 40 of the sample collecting device 1, and the guide cavity 440 of the buffer pre-storage part 40 guides the collecting part 10 to move the collecting part 10 toward the pre-storage cavity 420 until the collecting part 10 reaches the position of the sealing sheet 430.

[0112] In some embodiments, the collecting portion 10 continues to move toward the pre-storage cavity 420 and generates pressure on the sealing sheet 430 . The sealing sheet 430 fails under the pressure, allowing the collecting portion 10 to enter the pre-storage cavity 420 .

[0113] Step 730: flush the sample from the core into the detection portion of the sample collection device through the buffer to obtain a detection result.

[0114] In some embodiments, the pre-storage chamber 420 stores a buffer 410, and the collection end 310 of the collection unit 10 can be immersed in the buffer 410. As the core 110 is inserted into the pre-storage unit 40, the space in the pre-storage unit 40 is reduced, so that the buffer 410 flows from the gap 111 of the core 110 to the detection chamber 210, thereby flushing the sample from the core 110 into the detection chamber 210. In some embodiments, the sample is quickly flushed into the detection chamber 210 of the detection unit 20 from the second channel 340 by the buffer 410, and under the buffering effect of the buffer unit 260, it slowly flows to the detection element 220 in the detection chamber 210, and reaches the detection section 222 after passing through the adsorption section 221 of the detection element 220.

[0115] In some embodiments, the detection section 222 detects components or indicators of the sample and obtains detection results.

[0116] The beneficial effects that may be brought about by the embodiments of the present application include but are not limited to: (1) The collection part includes a core body, which is hydrophilic. The hydrophilicity of the core body can increase the amount of sample absorbed to meet the detection requirements of the detection part, and the core body has a fast absorption speed, which improves the collection speed; in addition, by utilizing the hydrophilicity of the core body, after the core body absorbs the sample, the sample is stored on the core body with strong stability and is less affected by gravity, which can not only prevent the sample from flowing back, but also allow the collection part to absorb the sample at any angle in space, making the sample collection operation simpler and more casual. (2) The fiber bundle structure has a gap inside for the sample to pass through, which can increase the hydrophilic area of ​​the core body and make the sample easier to be absorbed onto the core body. (3) The fiber bundle structure has adsorption properties for red blood cells in the sample. During the collection process, the red blood cells are retained in the fiber bundle structure, and the serum continues to flow into the detection cavity for detection, thereby preventing the red blood cells from affecting the detection results. (4) The detection element includes an adsorption section and a detection section arranged in sequence. The adsorption section is used to adsorb the red blood cells in the sample, so that a small amount of red blood cells entering the detection cavity are retained in the adsorption section. The detection accuracy of the detection element can be improved by the cooperation of the core body and the adsorption section. (5) Each of the multiple detection components detects one or more different detection contents, so multiple detection results can be obtained using one sample, which can improve the efficiency of the detection. (6) The sample collection device also includes a protective cap, which can completely cover the collection part to prevent the protective cap from contacting the sealing sheet, thereby preventing the sealing sheet from failing. It should be noted that different embodiments may produce different beneficial effects. In different embodiments, the beneficial effects that may be produced may be any one or a combination of the above, or any other possible beneficial effects.

[0117] The basic concepts have been described above. Obviously, for those skilled in the art, the above detailed disclosure is only for example and does not constitute a limitation of the present application. Although not explicitly stated herein, those skilled in the art may make various modifications, improvements and amendments to the present application. Such modifications, improvements and amendments are suggested in the present application, so such modifications, improvements and amendments still belong to the spirit and scope of the exemplary embodiments of the present application.

[0118] At the same time, the present application uses specific words to describe the embodiments of the present application. For example, "one embodiment", "an embodiment", and / or "some embodiments" refer to a certain feature, structure or characteristic related to at least one embodiment of the present application. Therefore, it should be emphasized and noted that "one embodiment" or "an embodiment" or "an alternative embodiment" mentioned twice or more in different positions in this specification does not necessarily refer to the same embodiment. In addition, some features, structures or characteristics in one or more embodiments of the present application can be appropriately combined.

Claims

1. A sample collection device, characterized in that: include: A collection unit, a detection unit, and a connection unit connecting the collection unit and the detection unit; The collecting part includes a core body, the connecting part includes a hollow structure, at least a part of the core body is arranged in the hollow structure, and the hollow structure can accommodate and fix the core body; The core is hydrophilic; The hollow structure is provided with a first channel and a second channel, the first channel and the second channel are interconnected and pass through the connecting part, one end of the first channel forms the entrance of the connecting part, and one end of the second channel forms the exit of the connecting part; the inner diameter of the first channel is larger than the inner diameter of the second channel; the first channel is used to install the core body, and the second channel is configured as a hollow channel for guiding flow.

2. The sample collection device according to claim 1, characterized in that: The core body comprises a hydrophilic fiber bundle structure, and the fiber bundle structure has gaps therein for the sample to pass through.

3. The sample collection device according to claim 2, characterized in that: The fiber bundle structure has adsorption properties to red blood cells in the sample.

4. The sample collection device according to claim 1, characterized in that: The connecting part comprises a collecting end, and the collecting end is far away from the detecting part; the collecting end has a notch, and a part of the surface of the core body is exposed from the notch.

5. The sample collection device according to claim 1, characterized in that: The core is disposed in the first channel, and the outer diameter of the core is greater than the inner diameter of the second channel.

6. The sample collection device according to claim 1, characterized in that: At least one supporting structure is arranged on the inner wall of the first channel, and the supporting structure protrudes from the inner wall of the first channel; the at least one supporting structure abuts against the peripheral side of the core body.

7. The sample collection device according to claim 2, characterized in that: The detection part includes a detection cavity, and the gap of the core is connected to the detection cavity through the hollow structure.

8. The sample collection device according to claim 7, characterized in that: The detection part includes a detection element arranged in the detection cavity.

9. The sample collection device according to claim 8, characterized in that: The detection element comprises an adsorption section and a detection section which are arranged in sequence; The adsorption section is used to adsorb red blood cells in the sample; The detection section is used for detecting samples.

10. The sample collection device according to claim 8, characterized in that: The detection element includes a plurality of detection pieces distributed along the radial direction of the detection cavity, and each of the plurality of detection pieces has different detection content.

11. The sample collection device according to claim 8, characterized in that: An operating port is provided at one end of the detection cavity away from the connecting portion, and the detection element is placed into and / or taken out of the detection cavity through the operating port; the operating port is provided with a sealing cover, and the sealing cover is detachably connected to the operating port.

12. The sample collection device according to claim 9, characterized in that: The detection part comprises a bracket for supporting the detection element; the bracket is connected to the inner wall of the detection cavity.

13. The sample collection device according to claim 7, characterized in that: The detection portion includes a buffer unit disposed between the connecting portion and the detection cavity, and the buffer unit is used to reduce a flow rate of the sample flowing toward the detection cavity.

14. The sample collection device according to claim 1, characterized in that: The detection part includes a connection end connected to the connection part, and the connection end is provided with a limiting structure; The connecting portion comprises a snap-fit ​​structure, and the snap-fit ​​structure is snap-fitted with the limiting structure to limit the separation of the collecting portion and the detecting portion.

15. The sample collection device according to claim 14, characterized in that: The connection portion comprises a stop structure, which is disposed around the circumference of the connection portion and extends in the radial direction of the connection portion, and the diameter of the stop structure is greater than the inner diameter of the connection end.

16. The sample collection device according to claim 4, characterized in that: The sample collection device further comprises a buffer pre-storage portion, wherein the buffer pre-storage portion comprises a buffer, a pre-storage cavity and a sealing sheet; The buffer is stored in the pre-storage chamber, and the sealing sheet seals the pre-storage chamber.

17. The sample collection device according to claim 16, characterized in that: The buffer pre-storage portion further includes a guide cavity connected to the pre-storage cavity, and the sealing sheet is disposed between the pre-storage cavity and the guide cavity.

18. The sample collection device according to claim 17, characterized in that: The collecting part is separately arranged from the buffer pre-storage part, and the collecting part enters the buffer pre-storage part through the guiding cavity.

19. A sample collection method, characterized in that: include: The sample is contacted by the collecting end of the connecting part of the sample collecting device, so that the core body absorbs and stores the sample; wherein the core body is arranged inside the connecting part, the connecting part includes a hollow structure, at least part of the core body is arranged in the hollow structure, and the hollow structure can accommodate and fix the core body; the core body is hydrophilic; the connecting part is provided with a first channel and a second channel, the first channel and the second channel are interconnected and pass through the connecting part, one end of the first channel forms the inlet of the connecting part, and one end of the second channel forms the outlet of the connecting part; the inner diameter of the first channel is greater than the inner diameter of the second channel; the first channel is used to install the core body, and the second channel is configured as a hollow channel for diversion; Inserting the connecting portion into the buffer pre-storage portion of the sample collection device so that the core body is inserted into the buffer in the buffer pre-storage portion; The sample is flushed from the core into the detection part of the sample collection device through the buffer to obtain a detection result.

20. The method according to claim 19, characterized in that The method further includes: connecting the connecting portion and the detecting portion.

21. The method according to claim 20, characterized in that The method further comprises: placing a detection element into the detection cavity of the detection part; The detection chamber is closed with a cover.

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