Health and vital signs monitoring patch with display and method of making the same

Abstract

A vital signs monitoring patch (VSM) with an integrated display includes a user access layer for accessing a display portion and a first printed silver-silver chloride (Ag-AgCl) electrode. A polyethylene foam layer includes a battery and a plunger cutout. A printed circuit board assembly (PCBA) layer includes a vital signs monitoring sensor and a battery and is connected to the first and second printed Ag-AgCl electrodes. The polyethylene foam layer is bonded to the user access layer and the PCBA layer. The sensor layer includes a reflective oximeter assembly and a second printed Ag-AgCl electrode. A hydrogel conductive adhesive is used to interact between the user's skin and the second printed Ag-AgCl electrode. A medical tape layer is bonded to the user's skin and the sensor layer. The plunger is connected to the PCBA layer and is configured to power the VSM, wherein user access to the first printed Ag-AgCl electrode completes a circuit with the second printed Ag-AgCl electrode.

Description

Technical Field

[0001] The present disclosure relates to electronic products, and more particularly to patches for monitoring and displaying health signs, vital signs, etc. Background Art

[0002] Vital sign monitoring devices are capable of measuring a variety of physiological parameters of a patient. These physiological parameters may include heart rate, electrocardiogram (ECG) signals, photoplethysmography (PPG) signals, and other similar signals and information. Vital sign monitoring devices come in many forms, including smart watches, wearable devices, and the like. As users become more health-conscious, the use of such devices has become popular. These devices can be used in a variety of environments, including medical facilities, homes, and workplaces, as well as while walking, exercising, and performing other activities. However, these devices lack a depiction of multi-parameter measurements associated with the multiple sensing modes on these devices, such as ECG, oxygen saturation, temperature, and pH. In addition, these devices may be expensive, require maintenance, and may be difficult to use or interpret. Therefore, there is a need for an easy-to-use vital sign monitoring device that may be more suitable and adaptable to a variety of environments. Summary of the Invention

[0003] Disclosed herein are embodiments of a health and / or vital sign monitoring patch with an integrated display and methods for making the patch or device.

[0004] In an embodiment, a vital sign monitoring patch with an integrated display includes: a user access layer configured to access at least a display portion and a first printed silver-silver chloride electrode, a polyethylene foam layer including at least a cutout for a power supply, wherein the polyethylene foam layer is arranged to be bonded to the user access layer, a printed circuit board assembly (PCBA) layer including at least one vital sign monitoring sensor and a power supply, the PCBA layer being connected to the first printed silver-silver chloride electrode and a second printed silver-silver chloride electrode, wherein the PCBA layer is arranged to be bonded to the polyethylene foam layer, a sensor layer including a reflective blood oxygen saturation measurement component and a second printed silver-silver chloride electrode, based on water a hydrogel-based conductive adhesive configured to contact a user surface area, wherein the hydrogel-based conductive adhesive is configured to interact between the user surface area and a second printed silver-silver chloride electrode, a medical tape layer, wherein the medical tape layer is configured to bond to the user surface area and the sensor layer, and a plunger arranged to operate within a cutout in the polyethylene foam layer and connected to the PCBA layer, wherein the plunger is accessible at the user access layer and configured to power the vital signs monitoring patch with an integrated display via a power source, and wherein user access to the first printed silver-silver chloride electrode completes an electrical circuit with the second printed silver-silver chloride electrode.

[0005] In an embodiment, a vital signs monitoring patch with an integrated display comprises: a top layer providing access to at least a display, a top printed silver-silver chloride electrode, and an activation device, a foam layer comprising at least cutouts for a power source and the activation device, wherein a polyethylene foam layer is arranged to be bonded to the top layer, a printed circuit board assembly (PCBA) layer having a top surface and a bottom surface, wherein the top surface comprises at least an electrocardiogram (ECG) sensor and a power source, the ECG sensor being connected to a first printed silver-silver chloride electrode and a second printed silver-silver chloride electrode, and the bottom surface comprising at least a blood oxygen saturation sensor and a second printed silver - a silver chloride electrode, and an activation device connected to the PCBA layer, a hydrogel-based conductive adhesive configured to contact the user's skin surface, wherein the hydrogel-based conductive adhesive is configured to interact between the user's skin area and the second printed silver-silver chloride electrode, and a contact layer, wherein the contact layer is configured to bond to the user's surface area and the bottom surface of the PCBA layer, and wherein the activation device is configured to power the vital signs monitoring patch with an integrated display via a power source, and wherein user access to the first printed silver-silver chloride electrode completes a circuit with the second printed silver-silver chloride electrode. BRIEF DESCRIPTION OF THE DRAWINGS

[0006] The present disclosure will be best understood from the following detailed description when read in conjunction with the accompanying drawings, which are incorporated into and thus constitute a part of this specification. It is emphasized that, according to common practice, the various features in the drawings are not drawn to scale. Instead, the dimensions of the various features have been arbitrarily expanded or reduced for clarity.

[0007] Figure 1 is an illustration of multiple layers in a vital signs monitoring patch with a display, according to certain embodiments.

[0008] Figure 2A-2E is a diagram of a reflectance oximetry assembly according to certain embodiments.

[0009] Figure 3 is a diagram of a reflectance oximetry assembly according to certain embodiments.

[0010] Figure 4 is a perspective view of a vital signs monitoring patch with a display, according to certain embodiments.

[0011] Figure 5 According to certain embodiments Figure 4 A top view of a vital signs monitoring patch with a display.

[0012] Figure 6 According to certain embodiments Figure 4 Side view of a vital signs monitoring patch with a display.

[0013] Figure 7 According to certain embodiments Figure 4 Illustration of the multiple layers of a vital signs monitoring patch with a display.

[0014] Figure 8 According to certain embodiments Figure 4 Bottom view of the printed circuit board layer of the vital signs monitoring patch with display.

[0015] Figure 8A According to certain embodiments Figure 8 Illustration of the reflectance oximetry components.

[0016] Figure 8B According to some embodiments, Figure 8 Block diagram of the readout circuit of the reflective blood oxygen saturation measurement system.

[0017] Figure 9 is an example diagram of the hardware architecture of a vital signs monitoring patch with a display, according to certain embodiments.

[0018] Figure 10 is an example diagram of a software architecture for a vital signs monitoring patch with a display, according to certain embodiments.

[0019] Figures 11A-11B is an example diagram of an interface screen on a device for interacting with a vital signs monitoring patch having a display, according to certain embodiments.

[0020] Figures 12A-12B is an example diagram of an interface screen on a device for interacting with a vital signs monitoring patch having a display, according to certain embodiments.

[0021] Figure 13 is a flow chart for reflective oxygen saturation measurement for a vital signs monitoring patch with a display, according to certain embodiments.

[0022] Figure 14 is an illustration of an example display architecture for a vital signs monitoring patch having a display, according to certain embodiments.

[0023] Figure 15 is an illustration of an example display architecture for a vital signs monitoring patch having a display, according to certain embodiments.

[0024] Figure 16A and Figure 16B is an illustration of an example display architecture for a vital signs monitoring patch having a display, according to certain embodiments. DETAILED DESCRIPTION

[0025] The accompanying drawings and description provided herein can be simplified to illustrate the aspects of the described embodiments relevant to clearly understanding the composition of the process, machine, manufacture and / or material disclosed herein, while eliminating other aspects that can be found in typical similar devices, systems, compositions and methods for the purpose of clarity. Therefore, those of ordinary skill in the art will recognize that other elements and / or steps may be desirable or necessary for implementing the apparatus, system, composition and method described herein. However, because such elements and steps are well known in the art, and because they are not conducive to a better understanding of the disclosed embodiments, the discussion of such elements and steps may not be provided herein. However, the disclosure is considered to inherently include all these elements, variations and modifications of the described aspects known to those of ordinary skill in the relevant art according to the discussion herein.

[0026] Embodiments are provided throughout to make this disclosure fully thorough and to fully convey the scope of the disclosed embodiments to those skilled in the art. Many specific details, such as examples of specific aspects, devices, and methods, are set forth to provide a thorough understanding of the embodiments of the present disclosure. However, it will be apparent to those skilled in the art that certain specific disclosed details do not need to be adopted, and that the embodiments may be embodied in different forms. Therefore, the exemplary embodiments set forth should not be construed as limiting the scope of the present disclosure.

[0027] The terms used herein are for the purpose of describing particular embodiments only and are not intended to be limiting. For example, as used herein, the singular forms "a," "an," and "the" are also intended to include the plural forms unless the context clearly indicates otherwise. The terms "comprising," "including," and "having" are inclusive and, therefore, specify the presence of the recited features, steps, operations, elements, and / or components, but do not preclude the presence or addition of one or more other features, steps, operations, elements, components, and / or combinations thereof.

[0028] Therefore, the steps, processes, and operations described herein should not be construed as necessarily requiring that they be performed in the particular order discussed or illustrated, unless specifically identified as a preferred or desired order of performance. It should also be understood that additional or alternative steps may be used in place of or in combination with the disclosed aspects.

[0029] In addition, although the terms first, second, third etc. can be used to describe various elements, steps or aspects in this article, these elements, steps or aspects should not be limited by these terms. These terms may only be used to distinguish an element or aspect from another. Therefore, when used in this article, terms such as "first", "second" and other numerical terms do not imply sequence or order unless the context clearly indicates. Therefore, the first element, step, component, region, layer or part discussed below can be referred to as the second element, step, component, region, layer or part, without departing from the teaching of the present disclosure.

[0030] As used herein, the terms "determine" and "identify" or any variations thereof include selecting, ascertaining, calculating, finding, receiving, determining, establishing, obtaining, or identifying or determining in any manner using one or more of the devices and methods shown and described herein.

[0031] As used herein, the terms "example," "embodiment," "implementation," "aspect," "feature," or "element" mean serving as an example, instance, or illustration. Unless expressly stated otherwise, any example, embodiment, implementation, aspect, feature, or element is independent of other examples, embodiments, implementations, aspects, features, or elements and can be used in combination with any other examples, embodiments, implementations, aspects, features, or elements.

[0032] As used herein, the term "or" is intended to mean an inclusive "or" rather than an exclusive "or." That is, unless specified otherwise or clear from the context, "X includes A or B" is intended to mean any natural inclusive permutation. That is, if X includes A; X includes B; or X includes A and B, then "X includes A or B" is satisfied in any of the foregoing cases. Furthermore, the articles "a" and "an" as used in this application and the appended claims should generally be construed to mean "one or more" unless specified otherwise or clear from the context to direct to a singular form.

[0033] As used herein, the term "computer" or "computing device" includes any unit or combination of units capable of performing any method disclosed herein or any part or parts thereof. For example, a "computer" or "computing device" may include at least one or more processors.

[0034] As used herein, the term "processor" refers to one or more processors, such as one or more special-purpose processors, one or more digital signal processors, one or more microprocessors, one or more controllers, one or more microcontrollers, one or more application processors, one or more central processing units (CPUs), one or more graphics processing units (GPUs), one or more digital signal processors (DSPs), one or more application-specific integrated circuits (ASICs), one or more application-specific standard products, one or more field-programmable gate arrays, any other type or combination of integrated circuits, one or more state machines, or any combination thereof.

[0035] As used herein, the term "memory" refers to any computer-usable or computer-readable medium or device that can tangibly contain, store, communicate, or transmit any signal or information that may be used by or in connection with any processor. For example, the memory can be one or more read-only memories (ROMs), one or more random access memories (RAMs), one or more registers, low-power double data rate (LPDDR) memories, one or more cache memories, one or more semiconductor storage devices, one or more magnetic media, one or more optical media, one or more magneto-optical media, or any combination thereof.

[0036] As used herein, the term "instructions" may include instructions or expressions for performing any method disclosed herein, or any part or parts thereof, and may be implemented in hardware, software, or any combination thereof. For example, instructions may be implemented as information stored in a memory, such as a computer program, which may be executed by a processor to perform any corresponding method, algorithm, aspect, or combination thereof, as described herein. Instructions, or a portion thereof, may be implemented as a dedicated processor or circuit, which may include dedicated hardware for performing any method, algorithm, aspect, or combination thereof as described herein. In some embodiments, portions of the instructions may be distributed across multiple processors on a single device, across multiple devices, which may communicate directly or through a network such as a local area network, a wide area network, the Internet, or a combination thereof.

[0037] As used herein, the term "application" generally refers to an executable software unit that implements or performs one or more functions, tasks, or activities. For example, an application may perform one or more functions, including but not limited to vital sign monitoring, health monitoring, phone calls, web browsers, e-commerce transactions, media players, travel arrangements and management, smart home management, entertainment, and so on. An executable software unit typically runs within a predetermined environment and / or processor.

[0038] The non-limiting embodiments described herein are about patches or devices and methods for making patches or devices, wherein the patches or devices are vital sign monitoring or health sign monitoring patches or devices with integrated displays. The patches or devices and methods for making patches or devices with integrated displays can be modified for a variety of applications and uses while remaining within the spirit and scope of the claims. The embodiments and variations described herein and / or shown in the accompanying drawings are presented by way of example only and do not limit the scope and spirit. The description herein may apply to all embodiments of the device and the method for making the device.

[0039] Disclosed herein are embodiments of health or life (collectively referred to as "vital") signs monitoring patches or devices (collectively referred to as "patches") with integrated displays and methods for manufacturing the patches. A vital signs monitoring patch with a display is a skin-contact patch on the outside of the body. The patch is easily attached to and removed from the user. The patch can use a combination of sensors, printed electronics, adhesives, batteries, display electronics, flexible materials, or housings. In one embodiment, a vital signs monitoring patch with a display includes a flexible display layer based on organic, electrochromic, or quantum dot display technology and materials. Parameters that can be displayed on the patch include, but are not limited to, heart rate (HR), heart rate variability (HRV), oxygen saturation (SpO2), surface temperature, pH level, and the like.

[0040] The vital signs monitoring patch with display integrates multiple sensing modalities, such as, but not limited to, single-lead or multi-lead electrocardiography (ECG), photoplethysmography (PPG), oxygen saturation mapping (blood oxygen saturation measurement), temperature monitoring, and pH monitoring, into a single wearable, disposable device. The device and the data captured are used to monitor time-varying injuries, such as open and / or closed wounds, trauma, pressure ulcers, post-surgical skin grafts, hydration, temperature regulation, hyperhidrosis, infection, muscle fatigue, dialysis, firefighting, stress, ischemic tissue states, etc., by tracking data from multiple sensing modalities and patch coverage area over time.

[0041] In one embodiment, the vital signs monitoring patch with a display is disposable. The disposable aspect means that the internal electronics and power supply are sealed and not exposed to the outside. This disposable aspect of the patch allows the structure to be sealed to provide a dust-proof patch. In addition, the patch can prevent temporary immersion of water. In one embodiment, the patch can have an International Electrotechnical Commission (IEC) protection rating of IPX 67. Due to its disposable nature, the patch can have a form factor that is small in size and weight. This allows the user to wear it easily without feeling too much discomfort.

[0042] In one embodiment, the various sensors may include, but are not limited to, a single-lead ECG sensor, a PPG sensor, a temperature sensor, and an accelerometer. In one embodiment, the PPG sensor is a reflective blood oxygen saturation sensor. In one embodiment, the reflective blood oxygen saturation sensor may include a light-emitting diode (LED) and a photodiode. The LED may be a red LED, a near-infrared (NIR) LED, and / or a green LED.

[0043] In one embodiment, the patch may include a low-power microcontroller with Bluetooth for communication, an analog front end (AFE) for measuring ECG and blood oxygen saturation measurement signals (PPG) and oxygen saturation (SpO2), screen-printed silver-silver chloride electrodes (Ag-AgCl), an accelerometer, a temperature sensor, a pH sensor, and a blood oxygen saturation measurement layer that includes an LED and a photodiode located on the same layer (or plane).

[0044] The patch is powered internally by a flexible battery as described herein. The flexible battery can allow the patch to operate in a continuous operation mode for a limited time period. For example, the limited time period can be 7 days. Data from the patch can be transmitted to a mobile device for display or analysis. In one embodiment, communication can be accomplished via wireless, Bluetooth, etc. The data can include real-time ECG data, heart rate, heart rate variability, fall detection, SpO2, pH, body surface temperature, etc. In one embodiment, the flexible battery is sealed. In one embodiment, the flexible battery is rechargeable.

[0045] Figure 1 is an illustration of the various layers in a vital signs monitoring patch 1000 with a display, according to certain embodiments.

[0046] Layer 1 of the vital signs monitoring patch 1000 with display is the user access layer 1100, which includes a display portion 1125 and a top ECG electrode 1150. The display portion 1100 is a printed light-emitting device that displays heart rate information, SpO2 level, body surface temperature, etc. from the ECG electrodes. In one embodiment, the display portion 1100 is a 3-digit 7-segment display. In one embodiment, the display portion 1100 may include multiple display portions for displaying different physiological parameters as described herein. In one embodiment, the display portion 1100 is implemented using organic, electrochromic, or quantum dot display technology and materials as described herein. In one embodiment, the display portion 1100 is flexible. The top ECG electrode 1150 is a screen-printed Ag-AgCl ECG electrode that can be touched or engaged by the user to complete the ECG sensor circuit.

[0047] Layer 2 is a polyethylene foam layer 1200 that may be adhered to the user access layer 1100. The polyethylene foam layer 1200 may have laser cuts 1210 for surrounding and protecting the power supply unit 1300 and assembled printed circuit board (PCBA) layer 1400 and a cutout 1220 for the on / off plunger.

[0048] Layer 3 is a power supply unit 1300. In one embodiment, the power supply unit 1300 can be a stack of lithium polymer or similar batteries, for example, providing 3.3V and 140mAh. In one embodiment, the power supply unit 1300 can be a flexible battery. The power supply unit 1300 provides power to the various components of the vital signs monitoring patch with display 1000.

[0049] Layer 4 is PCBA layer 1400, which may include active and passive components as described herein and adhered to layer 2. In one embodiment, PCBA layer 1400 may include, but is not limited to, an accelerometer, a pH sensor, and a temperature sensor. In one embodiment, the accelerometer may be used for activity tracking, such as step count, sleep efficiency, and sleep stages. In one embodiment, for example, one or more temperature sensors may be used to determine a temperature profile of a wound. The one or more temperature sensors may sense or monitor the surface temperature of a local body area. In one embodiment, the pH sensor may monitor the pH level of a local body area. The pH level may vary between 0 and 14 and, as described herein, may be displayed via layer 1. For example, the pH level of a normally healing wound ranges from 5.5 to 6.5, while the pH level of an unhealed wound is greater than 6.5. In one embodiment, the pH sensor may be a potentiometric pH sensor. In one embodiment, the pH sensor may be implemented using carbon / polyaniline and Ag-AgCl electrodes.

[0050] Figure 1 The bottom side of layer 5 is shown in FIG. Layer 5 is a sensor layer 1500 that can be adhered to the PCBA layer 1400. The sensor layer 1500 can include a reflective blood oxygen saturation measurement component 1525 and a bottom ECG electrode 1550. In one embodiment, the bottom ECG electrode 1550 can be a screen-printed Ag-AgCl ECG electrode that interacts with the user's skin via a hydrogel layer. For example, the bottom ECG electrode 1550 can contact an area of ​​chest skin near the heart. Other skin surface areas can also be used. In operation, the user can, for example, use the index finger of the hand to contact the top ECG electrode 1150 from the opposite side of the body (the right hand if the patch is placed near the heart). The contact of the index finger with the top ECG electrode 1150 completes the circuit with the bottom ECG electrode 1550 for a single-lead (two-electrode-based) ECG measurement.

[0051] In one embodiment, the data may be streamed to the device application via a Bluetooth connection. Figures 11A-11B FIG2 is an example diagram of an interface screen 11000 on a device for interacting with a vital sign monitoring patch having a display, according to certain embodiments. Interface screen 11000 may have a link or tab 11100 for selecting a submenu of an ECG graphical display 11200. ECG graphical display 11200 may stream a real-time ECG signal showing different QRS complexes and report heart rate and heart rate variability derived from RR peak intervals.

[0052] The oximeter senses oxygen saturation in tissue by optically quantifying the concentrations of oxyhemoglobin (HbO2) and deoxyhemoglobin (Hb). Pulse oximetry is a method of optically measuring the ratio of pulsating arterial blood by photoplethysmography (PPG) using at least two different wavelengths. PPG includes optoelectronic components such as LEDs and photodiodes. In one embodiment, the reflective oximetry component 1525 of layer 5 (also known as the oximetry layer) may include a 4×4 array 1530 of (4) red LEDs 1535, (4) NIR LEDs 1545, and (8) photodiodes 1540, totaling 16 pixels, to facilitate reflective oximetry measurement. In one embodiment, the 4×4 array 1530 provides a flexible reflective oximetry platform for single-point measurement of heart rate, heart rate variability, SpO2, and two-dimensional oxygenation mapping of local tissue.

[0053] The molar absorption coefficients of HbO2 and Hb are different at red and NIR wavelengths. The red LED 1535 and the NIR LED 1545 act as transmitters (converting electrical energy into light energy), wherein the light is transmitted at wavelengths of 610 nm and 725 nm, respectively. In one embodiment, and as Figure 3 As shown, red and green (530 nm) can also be used as an LED combination.

[0054] Photodiode 1540 senses the unabsorbed light from the LED. The signal is inverted by an operational amplifier. These signals are interpreted as light absorbed by the probed tissue and divided into direct current (DC) and alternating current (AC) components. The DC component is considered light absorbed by tissue, venous blood, and non-pulsating arterial blood. The AC component is considered light absorbed by pulsating arterial blood.

[0055] Data from the layer 5 reflectance oximetry component 1525 can be streamed to the device application. Figures 12A-12Bis an example diagram showing an interface screen 12000 on a device for interacting with a vital signs monitoring patch having a display, according to certain embodiments. The interface screen 12000 may have a link or tab 12100 for selection of a submenu of a patch oximeter display 12200. In the patch oximeter display 12200, a user may view a live stream of a PPG waveform having well-delineated ascending (rise) and dicrotic (notch) features. In one embodiment, the patch oximeter display 12200 may display a 2D contour map 12300 in real time that provides perfusion status of a local area sampled by an oxygen saturation measurement layer that includes an LED and a photodiode. The 2D contour map 12300 is, for example, displayed via a display associated with a pulse oximeter. Figure 2A-2E The array 1530 and Figure 7 The PCBA layer 7600 is enabled. In an embodiment, the patch oximeter display 12200 can display parameters reflecting PPG-specific heart rate, heart rate variability, and oxygen saturation. In one embodiment, the patch oximeter display 12200 can display surface temperature, pH level, and other biomarkers or physiological parameters.

[0056] In one embodiment, the size of the array may vary without departing from the scope of the specification or claims. In one embodiment, the number of pixels may vary without departing from the scope of the specification or claims. In one embodiment, the number of LEDs of a particular wavelength or frequency may vary without departing from the scope of the specification or claims. In one embodiment, different wavelengths or frequencies may be used without departing from the scope of the specification or claims.

[0057] Layer 6 is a spacer strip 1600 surrounding layer 5. Spacer strip 1600 can adhere to the user's skin and help hold the entire patch in place. For example, spacer strip 1600 can be a medical tape composed of a porous, highly breathable, white, elastic, multi-layer polyurethane / synthetic rubber-based nonwoven fabric. The nonwoven fabric can be coated with a pressure-sensitive adhesive on one side for bonding to the user's skin and an adhesive on the other side for bonding to layer 5.

[0058] As described above, the vital signs monitoring patch with a display may also include an application that can be run on a device, such as a mobile device, an end-user device, a cellular phone, an Internet Protocol (IP) device, a mobile computer, a laptop computer, a handheld computer, a PDA, a personal media device, a smartphone, a notebook computer, a notepad, a tablet phone, a smart watch, etc. (collectively referred to as a "user device"). The vital signs monitoring patch with a display can communicate wirelessly with the user device, and the application, together with the user device, can analyze, display, and provide alerts to the user of the vital signs data collected by the vital signs monitoring patch with a display. The vital signs monitoring patch with a display can interact with the application to measure, stream, and record real-time data, thereby providing the user with comprehensive sensing information. Figures 11A-11B and Figures 12A-12B is an example diagram of an interface screen for viewing sensor data as described herein.

[0059] Figure 2A-2E is a diagram of a reflective oximetry assembly 2000 according to certain embodiments. The reflective oximetry assembly 2000 may include an array of red LEDs 2100, NIR LEDs 2200, and photodiodes 2300, wherein the shaded areas reflect the luminous areas. In one embodiment, the reflective oximetry assembly 2000 may include a red LED array layer 2005, an NIR LED array layer 2010, and a photodiode array layer 2015. The red LED array layer 2005 may include red LEDs 2100 having a defined pattern and connectors 2105. The NIR LED array layer 2010 may include NIR LEDs 2200 having a defined pattern and connectors 2205. The photodiode array layer 2015 may include photodiodes 2300 having a defined pattern and connectors 2305. The reflective oximetry assembly 2000 may include a red LED array layer 2005, an NIR LED array layer 2010, and a photodiode array layer 2015. Figure 1 The PCBA layer 1400 is provided with an interface board 2400 of the PCBA. Connectors 2105, 2205, and 2305 are each connected to connectors 2110, 2210, and 2310 on the interface board 2400, respectively, to transmit or send signals to appropriate components on the PCBA.

[0060] In one embodiment, the red LED 2100 may emit at approximately 610 nm and the NIR LED 2200 may emit at approximately 725 nm. In one embodiment, the LED active area of ​​the red LED 2100 and the NIR LED 2200 may be approximately 7.0 x 7.0 mm. 2 In one embodiment, the photodiode active area may be approximately 7.0 x 7.0 mm. 2. In one embodiment, the spacing between the red LED 2100, NIR LED 2200 and photodiode 2300 can be approximately 5.0 mm. The AC and DC signal amplitudes decrease exponentially with increasing spacing between the emitter and the detector (or photodiode). The array configuration and spacing of the red LED 2100, NIR LED 2200 and photodiode 2300 enable 2D contour mapping of the skin surface near the patch contact area. This allows determination of blood flow, temperature and other physiological parameters at different points relative to the patch contact area, and therefore, physiological conditions at different points relative to, for example, a wound. For example, analysis of the 2D contour map may show that one portion of a wound is healing, but another portion of the wound is not.

[0061] Figure 3 is a schematic diagram of a reflective oximetry assembly 3000 according to certain embodiments. In one embodiment, the reflective oximetry assembly 3000 may include an array of red LEDs 3100, green LEDs 3200, and photodiodes 3300. In one embodiment, the red LEDs 3100 may emit at approximately 610 nm and the green LEDs 3200 may emit at approximately 530 nm. In one embodiment, the LED active areas of the red and green LEDs 3100 and 3200 may be approximately 10.0 x 10.0 mm. 2 In one embodiment, the spacing between the red LED 3100, the NIR LED 3200, and the photodiode 3300 may be approximately 5.0 mm.

[0062] Figure 4 is a perspective view of a vital signs monitoring patch 4000 with a display, according to certain embodiments. Figure 5 According to certain embodiments Figure 4 A top view of a vital signs monitoring patch with a display. Figure 6 According to certain embodiments Figure 44. A side view of a vital signs monitoring patch with a display. The vital signs monitoring patch with a display 4000 may include a power button 4100, a display portion 4200, and a front or top ECG electrode 4300. In one embodiment, the vital signs monitoring patch with a display 4000 may include a charging port 4400. The power button 4100 is configured to turn the vital signs monitoring patch with a display 4000 on or off. The display portion 4200 depicts information related to physiological parameters sensed or captured by the vital signs monitoring patch with a display 4000 as described herein. The display portion 4200 is implemented as described herein. The front or top ECG electrode 4300 is part of a two ECG electrode configuration, wherein the bottom of the vital signs monitoring patch with a display 4000 includes a charging port 4400. Figure 6 The bottom ECG electrode 4350 is shown and functions or operates as described herein. The front or top ECG electrode 4300 is configured to minimize accidental or incidental touching of the front or top ECG electrode 4300. In one embodiment, the front or top ECG electrode 4300 is touchable at a plane below the plane of the display portion 4200. The charging port 4400 allows the vital signs monitoring patch with display 4000 to be charged. In one embodiment, the vital signs monitoring patch with display 4000 may include a wireless charger.

[0063] Figure 7 is an illustration of the various layers of a vital signs monitoring patch 4000 with a display, according to certain embodiments.

[0064] Layer 1 is a top cover 7100 that includes a cutout 7110 for accessing the front or top ECG electrodes 7620, a cutout 7120 for the display 7400, and a power button indicator 7130 for the plunger or power button 7200. In one embodiment, the top cover 7100 can be a self-adhesive paper or acrylic material that includes an adhesive on the bottom surface of the top cover 7100.

[0065] Layer 2 is a plunger or power button 7200, which contacts the top cover 7100 at the power button indicator 7130 and contacts the PCBA layer 7600 of Layer 6 via a cutout 7330 in Layer 3. Pressing the power button indicator 7130 engages the plunger or power button 7200, which in turn toggles a switch on the PCBA layer 7600, for example, to turn on the vital signs monitoring patch 4000 with a display.

[0066] Layer 3 is a foam spacer 7300 that includes a cutout 7310 for the front or top ECG electrode 7620, a cutout 7320 for the display 7400, and a cutout 7330 for the plunger or power button 7200. In one embodiment, the foam spacer 7300 is a double-sided adhesive-coated polyurethane foam tape used to bond with the top cover 7000 and PCBA layer 7600. In one embodiment, the foam spacer 7300 has a defined thickness to mitigate inadvertent completion of the ECG circuit, provides for placement of the display 7400, and provides for placement of the battery 7500.

[0067] Layer 4 is display 7400. In one embodiment, display 7400 is a 3-digit 7-segment display that depicts at least the physiological parameters described herein. In one embodiment, display 7400 is implemented as described herein. Display 7400 is electrically and mechanically connected to PCBA layer 7600.

[0068] Layer 5 is battery 7500. In one embodiment, battery 7500 is a lithium polymer battery or battery pack. In one embodiment, battery 7500 is rechargeable. Battery 7500 is connected to PCBA layer 7600 and / or display 7400.

[0069] Layer 6 is PCBA layer 7600. PCBA 7600 includes active and passive component portion 7610, front or top ECG electrode 7620 on one side or top surface of PCBA layer 7600, and bottom ECG electrode on the other side or bottom surface of PCBA layer 7600. In an embodiment, PCBA layer 7600 can be a substrate of polyimide, polyethylene terephthalate (PET), thermoplastic polyurethane (TPU), or the like. In an embodiment, passive components included in active and passive component portion 7610, such as resistors, capacitors, and inductors, can be additionally added using various processes (e.g., inkjet, selective coating, screen printing, dispensing, transfer, lamination, curing, and / or subtractive adjustment according to traditional PCB manufacturing processes (e.g., masking, etching, etc., or sheet-to-sheet or roll-to-roll processing)). In an embodiment, the active and passive component portions 7610, the front or top ECG electrode 7620, the bottom ECG electrode, the power button indicator 7130, the plunger or power button 7200, the display 7400, and the battery 7500 can be electrically connected to each other using traces where appropriate and applicable, and the traces can be additionally added by using various processes such as inkjet, selective coating, screen printing, dispensing, transfer, lamination, curing, or subtractive addition according to traditional PCB manufacturing processes such as masking, etching, etc., or sheet-to-sheet or roll-to-roll processes.

[0070] Layer 7 is a double-sided medical tape layer 7700 that includes cutouts 7710 for active and passive component sections 7610 and cutouts 7720 for bottom ECG electrodes. Double-sided medical tape layer 7700 has adhesive on both sides that bonds to PCBA layer 7600 and medical tape layer 7800.

[0071] Layer 8 is a medical tape layer 7800 that includes cutouts 7810 for the active and passive component portions 7610 and cutouts 7820 for the bottom ECG electrodes. The medical tape layer 7800 includes a medical adhesive for bonding to the user's skin surface.

[0072] Layer 9 is a hydrogel conductive adhesive patch 7900 connected to the bottom ECG electrode 7630.

[0073] Figure 8 7 is a bottom view of a PCBA layer 7600 according to certain embodiments. The bottom surface 8000 of the PCBA layer 7600 includes, for example, a first temperature sensor 8100, a second temperature sensor 8200, a bottom ECG electrode 8300, and a reflective blood oxygen saturation measurement component 8400. In one embodiment, the bottom ECG electrode 8300 may be a screen-printed Ag-AgCl electrode. In one embodiment, the reflective blood oxygen saturation measurement component 8400 may be a screen-printed Ag-AgCl electrode. Figure 2A-2E , configured, operated, and operative as shown in . In one embodiment, the reflective oximetry assembly 8400 can be configured, operated, and operative as described in the specification herein. In one embodiment, the reflective oximetry assembly 8400 can include a red LED 8410, a NIR LED 8420, and a photodiode 8430, the functions and operations of which are as described in the specification herein. The first temperature sensor 8100 and the second temperature sensor 8200 allow for the generation of a temperature profile for the wound, for example, to determine whether healing is progressing. The parameters can be displayed on the display 7400 or transmitted to another device that can display, for example, a 2D thermal profile. In an embodiment, the LEDs, photodiodes, and other components that are surface mount technology components or chips can be connected using solder, conductive adhesives, anisotropic conductive film (ACF), wire bonding, thermosonic bonding (which can be deposited by printing, inkjet, selective coating, screen printing, dispensing, lamination, curing, and / or bonding). In an embodiment, the LEDs and photodiodes can be placed discretely or in groups or transferred to a reel. In embodiments, LEDs and photodiodes can be top- or bottom-initiated. In the case of bottom-initiated assemblies, the assembly can be placed on the top side of the substrate, with a cavity in the curved portion to expose the active area. In the case of top-initiated assemblies, the assembly can be attached to the bottom side of the substrate. In embodiments, SMT assemblies can be encapsulated for reinforcement.

[0074] Figure 8A 8 is a diagram of a reflective oximetry assembly 8400 according to certain embodiments. The reflective oximetry assembly 8400 can be configured in an array 8405, which can include an array of red LEDs 8410 (shown as R1-R4), an array of NIR LEDs 8420 (shown as N1-N4), and an array of photodiodes 8430 (shown as P1-P8), each of which is configured in a defined pattern. Readout from the array 8405 can be achieved by sampling in a raster format. In one embodiment, the raster pattern 8500 can be performed from top to bottom. In one embodiment, the array 8405 can be read out by sampling the readout blocks 8600 from readout block 1 to readout block 9 (RB1-RB9). As an illustrative example, RB1 may include P1, R1, N1, and P2, RB2 may include R1, P3, P2, and N2, RB3 may include P3, R2, N2, and P4, RB4 may include N1, P8, P2, and R4, RB5 may include P2, R4, N2, and P6, RB6 may include N2, P6, P4, and R3, RB7 may include P8, N4, R4, and P7, RB8 may include R4, P7, P6, and N3, and RB9 may include P6, N3, R3, and P5. In embodiments, light guides may be additionally added using various processes such as inkjet, selective coating, screen printing, dispensing, transfer, lamination, curing, or subtractive addition according to conventional PCB manufacturing processes such as masking, etching, etc., laser trimming, or sheet-to-sheet or roll-to-roll processing.

[0075] Figure 8B Figure 8 is a block diagram of a readout circuit 8600 for a reflectance oximetry system, according to certain embodiments. The readout circuit 8600 includes a multiplexer 8700 connected to an analog front end (AFE) 8750 and a low-power processor 8800 with Bluetooth. The AFE 8750 connects to and receives inputs (IN1-IN3) from a photodiode (PD) 8900 and controls the transmission (TX1-TX4) of a red LED 8910 and a NIR LED 8920. In one embodiment, the red LED 8910 and NIR LED 8920 are turned on / off by current sources within the multiplexer 8700 and the AFE 8750. The current generated by the photodiode 8900 is converted to a voltage (transimpedance amplifier), time-demultiplexed, and digitized back through the AFE 8750 before being transmitted to an application on a mobile device 8950. The AFE 8750, red LED 8910, NIR LED 8920, photodiode 8900, and low power processor with Bluetooth 8800 may function and operate as described in the specification herein.

[0076] Figure 9 is an example diagram of the hardware architecture of a vital signs monitoring patch with a display 9000 according to certain embodiments. The vital signs monitoring patch with a display 9000 includes printed Ag-AgCl electrodes 9100, a negative electrode, and a positive electrode for performing ECG measurements. In one embodiment, the printed Ag-AgCl electrodes 9100 are screen-printed on different sides of a PCB. The Ag-AgCl electrodes 9100 are connected to an analog front end (AFE) 9200, which further includes connections from an accelerometer 9300 and a PPG sensor 9400 (displayed as blood oxygen saturation SpO2). The AFE 9200 is connected to a processor 9500, which is further connected to an LED display 9600, a temperature sensor 9700, a pH sensor 9800, and an antenna 9900. In one embodiment, the processor 9500 is a low-power MCU with integrated Bluetooth. In one embodiment, the antenna 9900 is Bluetooth and can communicate with the device 9950 using a corresponding antenna 9975. In one embodiment, the hardware architecture may be partially implemented on the PCBA layer 7600 .

[0077] Figure 10 10000 is an example diagram of the software architecture of a vital signs monitoring patch with a display 10000 according to certain embodiments. The processor software / firmware of the vital signs monitoring patch with a display 10000 includes, but is not limited to, a power module 10100, a data transmission module 10150, and drivers 10200 for LEDs 10210, an AFE 10220, a Bluetooth protocol stack 10230, an accelerometer 10240, a display 10250, a temperature sensor 10260, an oximeter 10270, a serial peripheral interface (SPI) 10280, an ECG sensor, and the like. An application device 10500 may include, but is not limited to, applications for processing and displaying PPG data 10510, ECG data 10520, heart rate variability data 10530, temperature 10540, step / fall detection (via the accelerometer) 10550, blood pressure, and the like. The application device also includes a data storage module 10580, a Bluetooth protocol stack 10585, and other libraries 10590. In one embodiment, the software / firmware architecture may be partially implemented on or in conjunction with the processor 9500 .

[0078] Figure 1313000 is a flow chart of a method 13000 for reflective oximetry measurement of a vital signs monitoring patch with a display, according to some embodiments. Method 13000 includes: dividing the oximetry layer into a defined set of pixel regions (13100); sampling each pixel region at a defined sampling rate (13200); mapping data from the defined set of pixel regions (13300); and generating a 2D spatial map (13400). Method 13000 may be implemented in part by processor 9500, display 9600, and other applicable components.

[0079] Method 13000 includes dividing the blood oxygen saturation measurement layer into a defined set of pixel regions (13100). Each pixel region of the defined set of pixel regions may include a pair of LEDs and a pair of photodiodes. In one embodiment, the pair of LEDs includes a red LED and a NIR LED. In one embodiment, the pair of LEDs includes a red LED and a green LED.

[0080] Method 13000 includes sampling each pixel region at a defined sampling rate (13200). Each pixel region in the defined group of pixel regions is sampled at the defined sampling rate in a defined pattern. In one embodiment, the defined pattern is a raster pattern. In one embodiment, the defined sampling rate is 500 Hz.

[0081] Method 13000 includes rendering data from a defined set of pixel regions (13300). Rendering data from the defined set of pixel regions uses one or more interpolation techniques. In one embodiment, the one or more interpolation techniques are nearest neighbor interpolation.

[0082] Method 13000 includes generating a 2D spatial map (13400). The 2D contour map is generated based on the plotted data of different parameters. For example, 2D contour maps can be generated for red LED, NIR LED, green LED, ΔSpO2, and other similar parameters.

[0083] Figure 14 14 is a diagram of an example organic light emitting diode (OLED) stack 14000 for a vital signs monitoring patch with a display, according to certain embodiments. OLED stack 14000 may include a sealing layer 14100, a cathode layer 14200, an emissive layer 14300, a conductive layer 14400, an anode layer 14500, and a substrate 14600. In one embodiment, emissive layer 14300 may be an organic compound film that emits light in response to current injection. The organic compound may be an organic polymer, ink, a light emitting polymer, or the like. In one embodiment, conductive layer 14400 may be an organic polymer, ink, or the like.

[0084] Figure 15 is an illustration of an example electrochromic device (ECD) stack 15000 for a vital signs monitoring patch with a display, according to certain embodiments. The ECD stack may include a substrate 15100, an electrolyte layer 15200, electrochromic layers 15300 and 15310, electrodes 15400 and 15410, and a substrate 15500. In this case, the electrochromic material is an organic or inorganic substance that changes color when an electric current is applied. The ECD controls optical properties such as transmittance, absorptivity, reflectivity, and / or emissivity in a continuous but reversible manner by applying a voltage. The ECD can be printed on plastic, paper, etc. and provide a flexible but robust structure. The ECD uses ultra-low power and is activated by a small current. The ECD can be integrated with sensors for motion, touch, proximity, temperature, etc.

[0085] Figure 16A and Figure 16B It is the architecture of quantum dot light-emitting diode (QLED). Figure 16A This figure is a schematic diagram of a quantum dot 16000, a semiconductor particle with optical and electrical properties in the nanometer-sized region. Quantum dot 16000 generally consists of a core 16100, a shell 16200, and a ligand 16300. Core 16100 is the luminescent material, shell 16200 is a coating that protects core 16100, and ligand 16300 is a long-chain molecule that allows quantum dots to be printed in liquid form.

[0086] Figure 16B Figure 1 is an illustration of a QLED stack 16500 for a vital signs monitoring patch with a display, according to certain embodiments. QLED stack 16500 includes a negative voltage electrode 16600, a charge injection material layer 16650, a core-shell quantum dot layer 16700, a charge injection layer 16750, a positive voltage electrode 16800, and a transparent substrate 16850. QLEDs produce pure monochromatic light (red, green, and blue) with low power consumption. Charge injected into QLED stack 16500 results in electroluminescence. The chemical composition and size of the quantum dots allow the color of the emitted light to be tuned.

[0087] Generally, a vital signs monitoring patch with an integrated display includes a user access layer configured to provide access to at least a display portion and a first printed silver-silver chloride electrode, a polyethylene foam layer including at least a cutout for a power supply, wherein the polyethylene foam layer is arranged to be bonded to the user access layer, a printed circuit board assembly (PCBA) layer including at least one vital signs monitoring sensor and a power supply, the PCBA layer being connected to the first printed silver-silver chloride electrode and a second printed silver-silver chloride electrode, wherein the PCBA layer is arranged to be bonded to the polyethylene foam layer, and a sensor layer including a reflective blood oxygen saturation measurement component and a second printed silver-silver chloride electrode. , a hydrogel-based conductive adhesive configured to contact a user surface area, wherein the hydrogel-based conductive adhesive is configured to interact between the user surface area and a second printed silver-silver chloride electrode, a medical tape layer, wherein the medical tape layer is configured to bond to the user surface area and the sensor layer, and a plunger configured to operate within a cutout in the polyethylene foam layer and connected to the PCBA layer, wherein the plunger is accessible at the user access layer and is configured to power the vital signs monitoring patch with an integrated display via a power source, and wherein user access to the first printed silver-silver chloride electrode completes a circuit with the second printed silver-silver chloride electrode.

[0088] In one embodiment, the sensor layer is integrated into the bottom surface of the PCBA layer. In one embodiment, a first printed silver-silver chloride electrode is printed on the top surface of the PCBA layer. In one embodiment, the polyethylene foam layer has a cutout for the first printed silver-silver chloride electrode and has a defined thickness to mitigate the possibility of unintentional completion of a circuit between the first printed silver-silver chloride electrode and the second printed silver-silver chloride electrode. In one embodiment, the reflective oximetry assembly further includes a first wavelength light-emitting diode array, a second wavelength light-emitting diode array, and a photodiode array, wherein the first wavelength light-emitting diode array, the second wavelength light-emitting diode array, and the photodiode array are configured to enable contour mapping of the area covered by the patch. In one embodiment, at least one vital sign monitoring sensor is an electrocardiogram (ECG) sensor. In one embodiment, the PCBA layer further includes at least one temperature sensor. In one embodiment, the PCBA layer further includes a pair of temperature sensors configured to provide thermal profiles of the area covered by the patch. In one embodiment, the PCBA layer further includes a pH sensor. In one embodiment, the PCBA layer further includes an accelerometer configured to detect tilt and fall detection data. In one embodiment, the PCBA further comprises a wireless component configured to transmit at least vital sign data to a vital sign monitoring device. In one embodiment, the medical tape layer, the polyethylene foam layer, and the user access layer are arranged and configured to provide a bond and seal to prevent environmental exposure. In one embodiment, the user access layer includes a display portion.

[0089] Generally, a vital signs monitoring patch with an integrated display includes a top layer that provides access to at least a display, a top printed silver-silver chloride electrode, and an activation device, a foam layer that includes at least a cutout for a power source and the activation device, wherein the polyethylene foam layer is arranged to be bonded to the top layer, a printed circuit board assembly (PCBA) layer having a top surface and a bottom surface, wherein the top surface includes at least an electrocardiogram (ECG) sensor and a power source, the ECG sensor being connected to a first printed silver-silver chloride electrode and a second printed silver-silver chloride electrode, and the bottom surface includes at least a blood oxygen saturation sensor and a second printed silver -silver chloride electrode, and an activation device connected to the PCBA layer, a hydrogel-based conductive adhesive configured to contact the user's skin surface, wherein the hydrogel-based conductive adhesive is configured to interact between the user's skin area and the second printed silver-silver chloride electrode, and a contact layer, wherein the contact layer is configured to bond to the user's surface area and the bottom surface of the PCBA layer, and wherein the activation device is configured to power the vital signs monitoring patch with an integrated display via a power source, and wherein user access to the first printed silver-silver chloride electrode completes a circuit with the second printed silver-silver chloride electrode.

[0090] In one embodiment, the foam layer has a defined thickness to mitigate situations where a circuit is unintentionally completed between the first printed silver-silver chloride electrode and the second printed silver-silver chloride electrode. In one embodiment, the blood oxygen saturation sensor further comprises a first wavelength light emitting diode array, a second wavelength light emitting diode array, and a photodiode array, wherein the first wavelength light emitting diode array, the second wavelength light emitting diode array, and the photodiode array are configured to achieve contour mapping of the patch coverage area. In one embodiment, the PCBA layer further comprises at least one temperature sensor, a pH sensor, and an accelerometer. In one embodiment, the at least one temperature sensor is a pair of temperature sensors configured to provide thermal distribution of the patch coverage area. In one embodiment, the patch includes a rechargeable base configured to recharge the power supply. In one embodiment, the display is a printed display.

[0091] The construction and arrangement of the method as shown in the various exemplary embodiments are only illustrative. Although only several embodiments are described in detail in the present disclosure, many modifications are possible (for example, the size, dimensions, structure, shape and proportion changes of various elements, parameter values, installation arrangements, use of materials and components, colors, directions, etc.). For example, the position of the element can be reversed or otherwise changed, and the nature or quantity of the discrete element or position can be changed or changed. Therefore, all these modifications are intended to be included within the scope of the present disclosure. According to alternative embodiments, the order or sequence of any process or method step can be changed or reordered. Without departing from the scope of the present disclosure, other replacements, modifications, changes and omissions can be made in the design, operating conditions and arrangement of the exemplary embodiments.

[0092] Although the accompanying drawings may show a specific order of method steps, the order of the steps may vary from that depicted. Two or more steps may also be performed simultaneously or partially simultaneously. Such variations will depend on the software and hardware systems selected and the designer's choice. All such variations are within the scope of this disclosure. Similarly, software implementations can be accomplished using standard programming techniques and rule-based logic and other logic to accomplish the various connection steps, processing steps, comparison steps, and decision steps.

[0093] While the present disclosure has been described in conjunction with certain embodiments, it should be understood that the disclosure is not limited to the disclosed embodiments, but on the contrary is intended to cover various modifications and equivalent arrangements included within the scope of the appended claims, which scope should be accorded the broadest interpretation so as to encompass all such modifications and equivalent structures permitted by law.

Claims

1. A vital signs monitoring patch with an integrated display, comprising: a user access layer configured to be able to access at least the display portion and the first printed silver-silver chloride electrode; a polyethylene foam layer comprising at least a cutout for a power supply, wherein the polyethylene foam layer is arranged to be bonded to the user access layer; a printed circuit board assembly (PCBA) layer comprising at least one vital sign monitoring sensor and the power supply, the PCBA layer being connected to the first and second printed silver-silver chloride electrodes, wherein the PCBA layer is arranged to be bonded to the polyethylene foam layer; a sensor layer comprising a reflective blood oxygen saturation measurement component and the second printed silver-silver chloride electrode; a hydrogel-based conductive adhesive configured to contact a user surface area, wherein the hydrogel-based conductive adhesive is configured to interact between the user surface area and the second printed silver-silver chloride electrode; a medical tape layer, wherein the medical tape layer is configured to bond to the user surface area and the sensor layer; and a plunger arranged to operate within a cutout in the polyethylene foam layer and connected to the PCBA layer, wherein the plunger is accessible at the user access layer and is configured to power the vital signs monitoring patch with an integrated display via the power supply, and The user's access to the first printed silver-silver chloride electrode completes the circuit with the second printed silver-silver chloride electrode.

2. The patch according to claim 1, wherein The sensor layer is integrated into the bottom surface of the PCBA layer.

3. The patch according to claim 2, wherein: The first printed silver-silver chloride electrode is printed on the top surface of the PCBA layer.

4. The patch of claim 3, further comprising a light guide connected to at least the reflective oximetry component.

5. The patch according to claim 4, wherein: The polyethylene foam layer has a cutout for the first printed silver-silver chloride electrode and has a defined thickness to mitigate unintentional completion of a circuit between the first printed silver-silver chloride electrode and the second printed silver-silver chloride electrode.

6. The patch according to any one of claims 1 to 5, wherein: The reflective blood oxygen saturation measurement component also includes: a first wavelength light emitting diode array; a second wavelength light emitting diode array; and Photodiode array, The first wavelength light emitting diode array, the second wavelength light emitting diode array, and the photodiode array are configured to achieve contour mapping of the patch coverage area.

7. The patch according to claim 6, wherein: The at least one vital sign monitoring sensor is an electrocardiogram (ECG) sensor.

8. The patch according to claim 7, wherein: The PCBA layer also includes at least one temperature sensor.

9. The patch according to claim 8, wherein: The PCBA layer also includes a pair of temperature sensors configured to provide thermal distribution of the patch coverage area.

10. The patch according to claim 9, wherein: The PCBA layer also includes a pH sensor.

11. The patch according to claim 10, wherein: The PCBA layer also includes an accelerometer configured to detect tilt and fall detection data.

12. The patch according to claim 11, wherein: The PCBA also includes a wireless component configured to transmit at least vital sign data to a vital sign monitoring device.

13. The patch according to claim 12, wherein: The medical tape layer, the polyethylene foam layer, and the user access layer are arranged and configured to provide a bond and a seal to prevent environmental exposure.

14. The patch according to claim 13, wherein: The user access layer includes the display part.

15. The patch according to claim 14, wherein: Traces connect the display portion, the first printed silver-silver chloride electrode, the power supply, the at least one vital sign monitoring sensor, the second printed silver-silver chloride electrode, and the reflective blood oxygen saturation measurement component.

16. A vital sign monitoring patch with an integrated display, comprising: a top layer, which provides access to at least the display, the top-printed silver-silver chloride electrodes, and the activation mechanism; a foam layer comprising at least cutouts for a power source and said activation means, wherein said foam layer is arranged to be bonded to said top layer; A printed circuit board assembly (PCBA) layer having a top surface and a bottom surface, wherein: The top surface includes at least an electrocardiogram (ECG) sensor and the power supply, the ECG sensor being connected to the top printed silver-silver chloride electrode and the bottom printed silver-silver chloride electrode; The bottom surface includes at least a blood oxygen saturation sensor and the bottom printed silver-silver chloride electrode; and The activation device is connected to the PCBA layer; a hydrogel-based conductive adhesive configured to contact a surface of a user's skin, wherein the hydrogel-based conductive adhesive is configured to interact between an area of ​​the user's skin and the bottom printed silver-silver chloride electrode; and a contact layer, wherein the contact layer is configured to bond to a user surface area and a bottom surface of the PCBA layer, wherein the activation device is configured to power the vital signs monitoring patch with an integrated display via the power supply, and The user's access to the top printed silver-silver chloride electrode completes the circuit with the bottom printed silver-silver chloride electrode.

17. The patch according to claim 16, wherein: The foam layer has a defined thickness to mitigate the unintentional completion of a circuit between the top printed silver-silver chloride electrode and the bottom printed silver-silver chloride electrode.

18. The patch according to claim 16, wherein The blood oxygen saturation sensor further includes: a first wavelength light emitting diode array; a second wavelength light emitting diode array; and Photodiode array, The first wavelength light emitting diode array, the second wavelength light emitting diode array, and the photodiode array are configured to achieve contour mapping of the patch coverage area.

19. The patch according to claim 18, wherein The PCBA layer also includes at least one temperature sensor, a pH sensor, an accelerometer, and a light guide.

20. The patch according to claim 19, wherein The at least one temperature sensor is a pair of temperature sensors configured to provide a thermal profile of the area covered by the patch.

21. The patch of claim 19, further comprising: A rechargeable base is configured to charge the power source.

22. The patch of claim 20, further comprising: Traces connecting the display, the top printed silver-silver chloride electrode, the activation device, the power supply, the ECG sensor, the bottom printed silver-silver chloride electrode, and the blood oxygen saturation sensor.

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