A kind of preparation method of 4-pyridinemethanol

By using acidic aqueous solution and lead electrode to perform electrolytic reaction of electrolytic isonicotinic acid ethyl ester at normal temperature and pressure, the current conditions and electrolytic time are optimized, and the high cost and low current efficiency problems of the preparation of 4-pyridinol in the prior art are solved, and a green and environmentally friendly process with high yield and high current efficiency is achieved.

CN115725987BActive Publication Date: 2025-04-29CHIBI HIGH QUALITY DEV RES INST CO LTD
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Patent Information

Application Number
CN202111015119.2
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2021-08-31
Publication Date
2025-04-29
Estimated Expiration
2041-08-31

AI Technical Summary

Technical Problem

The method for preparing 4-pyridinol in the prior art is high in cost, the process is not environmentally friendly, and the current efficiency of the electrocatalytic hydrogenation reaction is low, making it difficult to effectively suppress competitive reactions.

Method used

The acidic aqueous solution is used as the reaction medium, and the electrolytic reaction is performed with a constant current by electrolyzing ethyl isonicotinic acid under normal temperature and pressure conditions. The lead electrode is used as the cathode to optimize the current conditions, electrolysis time and reaction medium, inhibit the hydrogen evolution reaction, and improve the current efficiency.

Benefits of technology

The high yield and high current efficiency of 4-pyridinol are achieved, with a yield of up to 73%, and the current efficiency is maintained above 95%. The process is green and environmentally friendly and the cost is low.

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Abstract

The invention belongs to the technical field of preparation of pyridine derivatives, and particularly relates to a method for preparing 4-pyridinemethanol, wherein an acidic aqueous solution is used as a reaction medium, ethyl isonicotinate is used as a raw material, and an electrolytic reaction is carried out at a constant current under normal temperature and pressure to prepare 4-pyridinemethanol. The preparation method of the invention can be carried out at normal temperature and pressure, while avoiding the use of a reducing agent, a transition metal catalyst and an organic solvent, the preparation process is green and environmentally friendly, the obtained 4-pyridinemethanol has a high yield, a strong atom economy, and has a strong market application prospect.
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